Claims
- 1. An isolated polypeptide comprising 100 or more contiguous amino acid residues of SEQ ID NO:2.
- 2. An isolated polypeptide according to claim 1, wherein said polypeptide comprises 150 or more contiguous amino acid residues of SEQ ID NO:2.
- 3. An isolated polypeptide according to claim 1, wherein said contiguous amino acid residues are selected from the group consisting of:
a) amino acid residues 40-154 of SEQ ID NO:2; b) amino acid residues 40-270 of SEQ ID NO:2; and c) amino acid residues 24-270 of SEQ ID NO:2;.
- 4. An isolated polypeptide according to claim 1, wherein said polypeptide specifically binds to an antibody to which a polypeptide of SEQ ID NO:2 specifically binds.
- 5. An isolated polypeptide according to claim 1, further comprising an affinity tag or binding domain.
- 6. An isolated polypeptide selected from the group consisting of:
a) amino acid residues 24-39 of SEQ ID NO:2; b) amino acid residues 40-154 of SEQ ID NO:2; c) amino acid residues 40-270 of SEQ ID NO:2; and d) amino acid residues 24-270 of SEQ ID NO:2.
- 7. An isolated polypeptide comprising the amino acid sequence of SEQ ID NO:2.
- 8. An isolated polynucleotide encoding a polypeptide according to claim 1.
- 9. An isolated polynucleotide according to claim 8, wherein said polypeptide comprises 150 or more contiguous amino acid residues of SEQ ID NO:2.
- 10. An isolated polynucleotide according to claim 8, wherein said contiguous amino acid residues are selected from the group consisting of:
a) amino acid residues 40-154 of SEQ ID NO:2; b) amino acid residues 40-270 of SEQ ID NO:2; and c) amino acid residues 24-270 of SEQ ID NO:2.
- 11. An isolated polynucleotide encoding a polypeptide selected from the group consisting of:
a) amino acid residues 24-39 of SEQ ID NO:2; b) amino acid residues 40-154 of SEQ ID NO:2; c) amino acid residues 40-270 of SEQ ID NO:2; and d) amino acid residues 24-270 of SEQ ID NO:2.
- 12. An isolated polynucleotide sequence which hybridizes under stringent conditions to a similarly sized polynucleotide sequence of SEQ ID NO:1.
- 13. An expression vector comprising the following operably linked elements:
a transcription promoter; a DNA segment encoding a polypeptide according to claim 1; and a transcription terminator.
- 14. An expression vector according to claim 26 further comprising a secretory signal sequence operably linked to said polypeptide encoded by said DNA segment.
- 15. An expression vector according to claim 26, wherein said DNA segment encodes a polypeptide covalently linked amino terminally or carboxy terminally to an affinity tag.
- 16. A cultured cell into which has been introduced an expression vector according the claim 14, wherein said cultured cell expresses said polypeptide encoded by said DNA segment.
- 17. A method of producing a polypeptide comprising:
culturing a cell into which has been introduced an expression vector according to claim 14; whereby said cell expresses said polypeptide encoded by said DNA segment; and recovering said expressed polypeptide.
- 18. An antibody or antibody fragment that specifically binds to a polypeptide according to claim 1.
- 19. An anti-idiotype antibody that specifically binds to said antibody of claim 18.
- 20. A polypeptide according to claim 1, in combination with a pharmaceutically acceptable vehicle.
REFERENCE TO RELATED APPLICATIONS
[0001] This application is related to Provisional Applications 60/169,758, filed on Dec. 9, 1999. Under 35 U.S.C. § 119(e)(1), this application claims benefit of said Provisional Application.
Provisional Applications (1)
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Number |
Date |
Country |
|
60169758 |
Dec 1999 |
US |