Claims
- 1. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:
(a) the nucleotide sequence of SEQ ID NO:70; (b) the nucleotide sequence of SEQ ID NO:70 from nucleotide 9 to nucleotide 1274; (c) the nucleotide sequence of SEQ ID NO:70 from nucleotide 604 to nucleotide 745; (d) the nucleotide sequence of the full-length protein coding sequence of clone AZ302—1 deposited with the ATCC under accession number 98076; (e) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone AZ302—1 deposited with the ATCC under accession number 98076; (f) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:71; (g) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:71, the fragment comprising eight contiguous amino acids of SEQ ID NO:71; (h) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4× SSC at 65 degrees C., or 4× SSC at 42 degrees C. with 50% formamide, to any one of the polynucleotides specified by (a)-(e); and (i) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4× SSC at 50 degrees C., or 6× SSC at 40 degrees C. with 50% formamide, to any one of the polynucleotides specified by (a)-(e), and that has a length that is at least 25% of the length of SEQ ID NO:70.
- 2. The polynucleotide of claim 1 wherein said polynucleotide is operably linked to at least one expression control sequence.
- 3. A host cell transformed with the polynucleotide of claim 2.
- 4. The host cell of claim 3, wherein said cell is a mammalian cell.
- 5. A process for producing a protein encoded by the polynucleotide of claim 2, which process comprises:
(a) growing a culture of a host cell in a suitable culture medium, wherein the host cell has been transformed with the polynucleotide of claim 2; and (b) purifying said protein from the culture.
- 6. A protein produced according to the process of claim 5.
- 7. An isolated polynucleotide encoding the protein of claim 6.
- 8. The polynucleotide of claim 7, wherein the polynucleotide comprises the cDNA insert of clone AZ302—1 deposited with the ATCC under accession number 98076.
- 9. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID NO:71; (b) a fragment of the amino acid sequence of SEQ ID NO:71, the fragment comprising eight contiguous amino acids of SEQ ID NO:71; and (c) the amino acid sequence encoded by the cDNA insert of clone AZ302—1 deposited with the ATCC under accession number 98076; the protein being substantially free from other mammalian proteins.
- 10. The protein of claim 9, wherein said protein comprises the amino acid sequence of SEQ ID NO:71.
- 11. A composition comprising the protein of claim 9 and a pharmaceutically acceptable carrier.
- 12. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:
(a) the nucleotide sequence of SEQ ID NO:185; (b) the nucleotide sequence of SEQ ID NO:185 from nucleotide 85 to nucleotide 582; (c) the nucleotide sequence of SEQ ID NO:185 from nucleotide 96 to nucleotide 454; (d) the nucleotide sequence of the full-length protein coding sequence of clone BD127—16 deposited with the ATCC under accession number 98155; (e) a nucleotide sequence encoding the full-length protein encoded by the cDNA insert of clone BD127—16 deposited with the ATCC under accession number 98155; (f) a nucleotide sequence encoding a protein comprising the amino acid sequence of SEQ ID NO:186; (g) a nucleotide sequence encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:186, the fragment comprising eight contiguous amino acids of SEQ ID NO:186; (h) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4× SSC at 65 degrees C., or 4× SSC at 42 degrees C. with 50% formamide, to any one of the polynucleotides specified by (a)-(e); and (i) the nucleotide sequence of a polynucleotide that hybridizes under conditions at least as stringent as 4× SSC at 50 degrees C., or 6× SSC at 40 degrees C. with 50% formamide, to any one of the polynucleotides specified by (a)-(e), and that has a length that is at least 25% of the length of SEQ ID NO:185.
- 13. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID NO:186; (b) the amino acid sequence of SEQ ID NO:186 from amino acid 5 to amino acid 123; (c) a fragment of the amino acid sequence of SEQ ID NO:186, the fragment comprising eight contiguous amino acids of SEQ ID NO:186; and (d) the amino acid sequence encoded by the cDNA insert of clone BD127—16 deposited with the ATCC under accession number 98155; the protein being substantially free from other mammalian proteins.
Parent Case Info
[0001] This application is a continuation-in-part of the following applications:
[0002] (1) Ser. No. 08/833,823 (GI 6000-DIV), filed Apr. 10, 1997, which is a divisional of Ser. No. 08/514,014 (GI 6000), filed Aug. 11, 1995 and issued as U.S. Pat. No. 5,707,829 on Jan. 13, 1998;
[0003] (2) Ser. No. 09/189,700 (GI 6000-DIV2), filed Nov. 10, 1998, which is a divisional of Ser. No. 08/833,823 (GI 6000-DIV), filed Apr. 10, 1997, which is a divisional of Ser. No. 08/514,014 (GI 6000), filed Aug. 11, 1995 and issued as U.S. Pat. No. 5,707,829 on Jan. 13, 1998;
[0004] (3) Ser. No. 08/866,022 (GI 6001.B121), filed May 30, 1997, which is a divisional of application Ser. No. 08/628,364 (GI 6001), filed Apr. 5, 1996, now abandoned;
[0005] (4) Ser. No. 08/924,838 (GI 6001.B196), filed Sep. 5, 1997, which is a divisional of application Ser. No. 08/628,364 (GI 6001), filed Apr. 5, 1996, now abandoned;
[0006] (5) Ser. No. 09/005,986 (GI 6001.B196A), filed Jan. 12, 1998, which is a continuation-in-part of application Ser. No. 08/924,838 (GI 6001.B196), filed Sep. 5, 1997, which is a divisional of application Ser. No. 08/628,364 (GI 6001), filed Apr. 5, 1996, now abandoned;
[0007] (6) Ser. No. 09/203,988 (GI 6001.D157-DIV), filed Dec. 2, 1998, which is a divisional of application Ser. No. 08/783,395 (GI 6001.D157), filed Jan. 13, 1997 and issued as U.S. Pat. No. 5,945,302 on Aug. 31, 1999, which was a continuation-in-part of application Ser. No. 08/628,364 (GI 6001), filed Apr. 5, 1996, now abandoned;
[0008] (7) Ser. No. 08/635,311 (GI 6002), filed Apr. 19, 1996;
[0009] (8) Ser. No. 08/781,226 (GI 6002A), filed Jan. 10, 1997, which is a continuation-in-part of application Ser. No. 08/635,311 (GI 6002), filed Apr. 19, 1996;
[0010] (9) Ser. No. 08/659,224 (GI 6003), filed Jun. 7, 1996;
[0011] (10) Ser. No. 08/867,677 (GI 6003.D147), filed Jun. 2, 1997, which is a continuation-in-part of application Ser. No. 08/659,224 (GI 6003), filed Jun. 7, 1996;
[0012] (11) Ser. No. 09/152,600 (GI 6004-DIV), filed Sep. 14, 1998, which is a divisional of application Ser. No. 08/664,596 (GI 6004), filed Jun. 17, 1996 and issued as U.S. Pat. No. 5,807,703 on Sep. 15, 1998;
[0013] (12) Ser. No. 09/153,264 (GI 6004.AS152A-DIV), filed Sep. 14, 1998, which is a divisional of application Ser. No. 08/739,775 (GI 6004.AS 152A), filed Oct. 30, 1996 and issued as U.S. Pat. No. 5,837,490 on Nov. 17, 1998, which was a continuation-in-part of application Ser. No. 08/721,923 (GI 6004.AS152), filed Sep. 27, 1996, now abandoned, which was a continuation-in-part of application Ser. No. 08/664,596 (GI 6004), filed Jun. 17, 1996 and issued as U.S. Pat. No. 5,807,703 on Sep. 15, 1998;
[0014] (13) Ser. No. 09/152,426 (GI 6004.C 195A-DIV), filed Sep. 14, 1998, which is a divisional of application Ser. No. 08/738,367 (GI 6004.C195A), filed Oct. 25, 1996 and issued as U.S. Pat. No. 5,827,688 on Oct. 27, 1998, which was a continuation-in-part of application Ser. No. 08/721,926 (GI 6004.C195), filed Sep. 27, 1996, now abandoned, which was a continuation-in-part of application Ser. No. 08/664,596 (GI 6004), filed Jun. 17, 1996 and issued as U.S. Pat. No. 5,807,703 on Sep. 15, 1998;
[0015] (14) Ser. No. 09/152,914 (GI 6004.0276-DIV), filed Sep. 14, 1998, which is a divisional of application Ser. No. 08/721,798 (GI 6004.0276), filed Sep. 27, 1996 and issued as U.S. Pat. No. 5,807,709 on Sep. 15, 1998, which was a continuation-in-part of application Ser. No. 08/664,596 (GI 6004), filed Jun. 17, 1996 and issued as U.S. Pat. No. 5,807,703 on Sep. 15, 1998;
[0016] (15) Ser. No. 08/721,488 (GI 6005A), filed Sep. 27, 1996, which is a continuation-in-part of application Ser. No. 08/677,231 (GI 6005), filed Jul. 9, 1996, now abandoned;
[0017] (16) Ser. No. 08/955,557 (GI 6005B), filed Oct. 18, 1997, which is a continuation-in-part of the following applications: (A) application Ser. No. 08/677,231 (GI 6005), filed Jul. 9, 1996, now abandoned; (B) application Ser. No. 08/701,819 (GI 6005.BM46), filed Aug. 23, 1996, now abandoned, which was a continuation-in-part of application Ser. No. 08/677,231 (GI 6005), filed Jul. 9, 1996, now abandoned; (C) application Ser. No. 08/721,488 (GI 6005A), filed Sep. 27, 1996, which is a continuation-in-part of application Ser. No. 08/677,231 (GI 6005), filed Jul. 9, 1996, now abandoned; and (D) application Ser. No. 08/739,066 (GI 6005A.AX56), filed Oct. 28, 1996, now abandoned, which was a continuation-in-part of application Ser. No. 08/721,488 (GI 6005A), filed Sep. 27, 1996, which is a continuation-in-part of application Ser. No. 08/677,231 (GI 6005), filed Jul. 9, 1996, now abandoned;
[0018] (17) Ser. No. 08/887,029 (GI 6006-DIV), filed Jul. 2, 1997, which is a divisional of application Ser. No. 08/686,878 (GI 6006), filed Jul. 26, 1996 and issued as U.S. Pat. No. 5,708,157 on Jan. 13, 1998;
[0019] (18) Ser. No. 08/721,924 (GI 6006.AP224), filed Sep. 27, 1996, which is a continuation-in-part of application Ser. No. 08/686,878 (GI 6006), filed Jul. 26, 1996 and issued as U.S. Pat. No. 5,708,157 on Jan. 13, 1998;
[0020] (19) Ser. No. 09/266,148 (GI 6006.AP224-DIV), filed Mar. 10, 1999, which is a divisional of application Ser. No. 08/721,924 (GI 6006.AP224), filed Sep. 27, 1996, which is a continuation-in-part of application Ser. No. 08/686,878 (GI 6006), filed Jul. 26, 1996 and issued as U.S. Pat. No. 5,708,157 on Jan. 13, 1998;
[0021] (20) Ser. No. 08/976,110 (GI 6006B), filed Nov. 21, 1997, which is a continuation-in-part of the following applications: (A) application Ser. No. 08/686,878 (GI 6006), filed Jul. 26, 1996 and issued as U.S. Pat. No. 5,708,157 on Jan. 13, 1998; (3) application Ser. No. 08/702,081 (GI 6006A), filed Aug. 23, 1996, now abandoned, which was a continuation-in-part of application Ser. No. 08/686,878 (GI 6006), filed Jul. 26, 1996 and issued as U.S. Pat. No. 5,708,157 on Jan. 13, 1998; (C) application Ser. No. 08/721,489 (GI 6006.AJ172), filed Sep. 27, 1996 and issued as U.S. Pat. No. 5,786,465 on Jul. 28, 1998, which was a continuation-in-part of application Ser. No. 08/686,878 (GI 6006), filed Jul. 26, 1996 and issued as U.S. Pat. No. 5,708,157 on Jan. 13, 1998; and (D) application Ser. No. 08/721,924 (GI 6006.AP224), filed Sep. 27, 1996, which is a continuation-in-part of application Ser. No. 08/686,878 (GI 6006), filed Jul. 26, 1996 and issued as U.S. Pat. No. 5,708,157 on Jan. 13, 1998; (21) Ser. No. 08/976,111 (GI 6007A), filed Nov. 21, 1997, which is a continuation-in-part of the following applications: (A) application Ser. No. 08/691,641 (GI 6007), filed Aug. 2, 1996 and issued as U.S. Pat. No. 5,728,819 on Mar. 17, 1998; and (B) application Ser. No. 08/702,297 (GI 6007.BL15), filed Aug. 23, 1996, now abandoned, which was a continuation-in-part of application Ser. No. 08/691,641 (GI 6007), filed Aug. 2, 1996 and issued as U.S. Pat. No. 5,728,819 on Mar. 17, 1998;
[0022] (22) Ser. No. 09/208,181 (GI 6008.H438-DIV), filed Dec. 9, 1998, which is a divisional of application Ser. No. 08/743,690 (GI 6008.H438), filed Nov. 6, 1996, now abandoned, which was a continuation-in-part of application Ser. No. 08/702,420 (GI 6008), filed Aug. 14, 1996, now abandoned;
[0023] (23) Ser. No. 09/179,034 (GI 6008A-DIV), filed Oct. 26, 1998, which is a divisional of application Ser. No. 08/701,931 (GI 6008A), filed Aug. 23, 1996, now abandoned, which was a continuation-in-part of application Ser. No. 08/702,420 (GI 6008), filed Aug. 14, 1996, now abandoned;
[0024] (24) Ser. No. 08/721,925 (GI 6008A.BL205), filed Sep. 27, 1996, which is a continuation-in-part of application Ser. No. 08/701,931 (GI 6008A), filed Aug. 23, 1996, now abandoned, which was a continuation-in-part of application Ser. No. 08/702,420 (GI 6008), filed Aug. 14, 1996, now abandoned;
[0025] (25) Ser. No. 08/975,936 (GI 6008B), filed Nov. 21, 1997, which is a continuation-in-part of the following applications: (A) application Ser. No. 08/743,690 (GI 6008.H438), filed Nov. 6, 1996, now abandoned, which was a continuation-in-part of application Ser. No. 08/702,420 (GI 6008), filed Aug. 14, 1996, now abandoned; (3) application Ser. No. 08/701,931 (GI 6008A), filed Aug. 23, 1996, now abandoned, which was a continuation-in-part of application Ser. No. 08/702,420 (GI 6008), filed Aug. 14, 1996, now abandoned; and (C) application Ser. No. 08/721,925 (GI 6008A.BL205); filed Sep. 27, 1996, which is a continuation-in-part of application Ser. No. 08/701,931 (GI 6008A), filed Aug. 23, 1996, now abandoned, which was a continuation-in-part of application Ser. No. 08/702,420 (GI 6008), filed Aug. 14, 1996, now abandoned;
[0026] (26) Ser. No. 08/976,112 (GI 6009A), filed Nov. 21, 1997, which is a continuation-in-part of application Ser. No. 08/702,344 (GI 6009), filed Aug. 23, 1996 and issued as U.S. Pat. No. 5,723,315 on Mar. 3, 1998;
[0027] (27) Ser. No. 09/196,027 (GI 6009A.CC365), filed Nov. 19, 1998, which is a continuation-in-part of application Ser. No. 08/976,112 (GI 6009A), filed Nov. 21, 1997, which is a continuation-in-part of application Ser. No. 08/702,344 (GI 6009), filed Aug. 23, 1996 and issued as U.S. Pat. No. 5,723,315 on Mar. 3, 1998;
[0028] (28) Ser. No. 08/858,830 (GI 6010.BD372), filed May 19, 1997, which is a divisional of application Ser. No. 08/702,080 (GI 6010), filed Aug. 23, 1996 and issued as U.S. Pat. No. 5,654,173 on Aug. 5, 1997;
[0029] (29) Ser. No. 08/858,834 (GI 6010.BR533), filed May 19, 1997, which is a divisional of application Ser. No. 08/702,080 (GI 6010), filed Aug. 23, 1996 and issued as U.S. Pat. No. 5,654,173 on Aug. 5, 1997;
[0030] (30) Ser. No. 09/080,695 (GI 6010.BR533A), fled May 18, 1998, which is a continuation-in-part of application Ser. No. 08/858,834 (GI 6010.BR533), filed May 19, 1997, which is a divisional of application Ser. No. 08702,080 (GI 6010), filed Aug. 23, 1996 and issued as U.S. Pat. No. 5,654,173 on Aug. 5, 1997;
[0031] (31) Ser. No. 09/292,550 (GI 6010A), filed Apr. 15, 1999, which is a continuation-in-part of the following applications: (A) application Ser. No. 08/858,830 (GI 6010.BD372), filed May 19, 1997, which is a divisional of application Ser. No. 08/702,080 (GI 6010), filed Aug. 23, 1996 and issued as U.S. Pat. No. 5,654,173 on Aug. 5, 1997; (B) application Ser. No. 08/858,834 (GI 6010.BR533), filed May 19, 1997, which is a divisional of application Ser. No. 08/702,080 (GI 6010), filed Aug. 23, 1996 and issued as U.S. Pat. No. 5,654,173 on Aug. 5, 1997; (C) application Ser. No. 09/080,695 (GI 6010.BR533A), filed May 18, 1998, which is a continuation-in-part of application 30 Ser. No. 08/858,834 (GI 6010.BR533), filed May 19, 1997, which is a divisional of application Ser. No. 08/702,080 (GI 6010), filed Aug. 23, 1996 and issued as U.S. Pat. No. 5,654,173 on Aug. 5, 1997; and (D) application Ser. No. 08/858,832 (GI 6010.CC288), filed May 19, 1997, now abandoned, which was a divisional application of Ser. No. 08/702,080 (GI 6010), filed Aug. 23, 1996 and issued as U.S. Pat. No. 5,654,173 on Aug. 5, 1997;
[0032] all of which are incorporated by reference herein.
Divisions (12)
|
Number |
Date |
Country |
Parent |
08514014 |
Aug 1995 |
US |
Child |
08833823 |
Apr 1997 |
US |
Parent |
08833823 |
Apr 1997 |
US |
Child |
09189700 |
Nov 1998 |
US |
Parent |
08514014 |
Aug 1995 |
US |
Child |
08833823 |
Apr 1997 |
US |
Parent |
08628364 |
Apr 1996 |
US |
Child |
08866022 |
May 1997 |
US |
Parent |
08628364 |
Apr 1996 |
US |
Child |
08924838 |
Sep 1997 |
US |
Parent |
08628364 |
Apr 1996 |
US |
Child |
08924838 |
Sep 1997 |
US |
Parent |
08783395 |
Jan 1997 |
US |
Child |
09203988 |
Dec 1998 |
US |
Parent |
08664596 |
Jun 1996 |
US |
Child |
09152600 |
Sep 1998 |
US |
Parent |
08739775 |
Oct 1996 |
US |
Child |
09153264 |
Sep 1998 |
US |
Parent |
08738367 |
Oct 1996 |
US |
Child |
09152426 |
Sep 1998 |
US |
Parent |
08721798 |
Sep 1996 |
US |
Child |
09152914 |
Sep 1998 |
US |
Parent |
08686878 |
Jul 1996 |
US |
Child |
08887029 |
Jul 1997 |
US |
Continuations (1)
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Number |
Date |
Country |
Parent |
09413232 |
Oct 1999 |
US |
Child |
10114893 |
Apr 2002 |
US |
Continuation in Parts (19)
|
Number |
Date |
Country |
Parent |
08833823 |
Apr 1997 |
US |
Child |
09413232 |
Oct 1999 |
US |
Parent |
08924838 |
Sep 1997 |
US |
Child |
09005986 |
Jan 1998 |
US |
Parent |
08628364 |
Apr 1996 |
US |
Child |
08783395 |
Jan 1997 |
US |
Parent |
08635311 |
Apr 1996 |
US |
Child |
08781226 |
Jan 1997 |
US |
Parent |
08867677 |
Jun 1997 |
US |
Child |
09413232 |
|
US |
Parent |
08659224 |
Jun 1996 |
US |
Child |
08867677 |
Jun 1997 |
US |
Parent |
08721923 |
Sep 1996 |
US |
Child |
08739775 |
Oct 1996 |
US |
Parent |
08664596 |
Jun 1996 |
US |
Child |
08721923 |
Sep 1996 |
US |
Parent |
08721926 |
Sep 1996 |
US |
Child |
08738367 |
Oct 1996 |
US |
Parent |
08664596 |
Jun 1996 |
US |
Child |
08721926 |
Sep 1996 |
US |
Parent |
08664596 |
Jun 1996 |
US |
Child |
08721798 |
Sep 1996 |
US |
Parent |
08677231 |
Jul 1996 |
US |
Child |
08721488 |
Sep 1996 |
US |
Parent |
08677231 |
Jul 1996 |
US |
Child |
08955557 |
Oct 1997 |
US |
Parent |
08701819 |
Aug 1996 |
US |
Child |
08955557 |
Oct 1997 |
US |
Parent |
08677231 |
Jul 1996 |
US |
Child |
08701819 |
Aug 1996 |
US |
Parent |
08677231 |
Jul 1996 |
US |
Child |
08721488 |
Sep 1996 |
US |
Parent |
08721488 |
Sep 1996 |
US |
Child |
08739066 |
Oct 1996 |
US |
Parent |
08677231 |
Jul 1996 |
US |
Child |
08721488 |
Sep 1996 |
US |
Parent |
08686878 |
Jul 1996 |
US |
Child |
08721924 |
Sep 1996 |
US |