Claims
- 1. A compound having structural formula Ia: whereinn is 0, 1, or 2; X is N-SO2R8; R6 is hydrogen, halo, or methoxy; R2 is hydrogen or methyl; R9 is hydrogen or halo; R4a and R4b are each independently selected from the group consisting of hydrogen, amidino, C1-4 alkyl, (CH2)0-1 aryl, (CH2)0-1C3-6 cycloalkyl, CO2R7, CO(CH2)0-1C(Me)2NH2, COC(Me)2NHCO2R7, (CH2)2OR7, COR7, CONR7R7, SO2R7, and SO2NR7R7; in which aryl is unsubstituted or substituted with one to three groups independently selected from R6; and alkyl and cycloalkyl are unsubstituted or substituted with one to three groups independently selected from R6 and oxo; each R7 is independently selected from the group consisting of hydrogen, C1-8 alkyl, (CH2)n-aryl, and (CH2)nC3-7 cycloalkyl; and R8 is selected from the group consisting of hydrogen, C1-8 alkyl, (CH2)n-aryl, and (CH2)nC3-7 cycloalkyl; wherein aryl is unsubstituted or substituted with one to three groups independently selected from R6; and alkyl, cycloalkyl, and (CH2)n are unsubstituted or substituted with one to three groups independently selected from R6 and oxo; or a pharmaceutically acceptable salt thereof.
- 2. The compound of claim 1 whereinR4a and R4b are each independently selected from the group consisting of hydrogen, C1-4 alkyl, (CH2)0-1 aryl, and (CH2)0-1C3-6 cycloalkyl; in which aryl is unsubstituted or substituted with one to three groups independently selected from R6; and alkyl and cycloalkyl are unsubstituted or substituted with one to three groups independently selected from R6 and oxo.
- 3. The compound of claim 1 wherein the carbon atom marked with * has the R configuration.
- 4. The compound of claim 2 wherein the carbon atom marked with * has the R configuration.
- 5. The compound of claim 1 of structural formula Ic selected from the group consisting of:IcR4aR4bHPhBocCbzBocHBocBocBocBocBocBocBocBocBocBocBocBocCbzCbzCbzHSO2MeHSO2N(Me)2HHHHHHHHHHHHHHHHHHor a pharmaceutically acceptable salt thereof.
- 6. A method for the treatment of obesity in a mammal in need thereof comprising administering to a mammal a therapeutically effective amount of a compound according to claim 1.
- 7. A method for the treatment of diabetes mellitus in a mammal in need thereof comprising administering to a mammal a therapeutically effective amount of a compound according to claim 1.
- 8. A method for the treatment of male or female sexual dysfunction in a mammal in need thereof comprising administering to a mammal a therapeutically effective amount of a compound according to claim 1.
- 9. A method for the treatment of erectile dysfunction in a mammal in need thereof comprising administering to a mammal a therapeutically effective amount of a compound according to claim 1.
- 10. A pharmaceutical composition which comprises a compound of claim 1 and a pharmaceutically acceptable carrier.
- 11. A method of treating male or female sexual dysfunction in a mammal in need thereof, comprising administering to the mammal a therapeutically effective amount of the composition of claim 10.
CROSS-REFERENCE TO RELATED APPLICATIONS
The present invention is related to U.S. provisional application Serial No. 60/191,669, filed Mar. 23, 2000, the contents of which are hereby incorporated by reference in their entirety.
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