Claims
- 1. A catheter assembly for delivering an expansible stent to a body lumen and lining said stent with a hydrogel, comprising
(a) a catheter comprising a balloon at least a portion of which is coated with a hydrogel; and (b) said stent mounted on said balloon in a contracted condition for passage with said catheter into said body lumen whereby expansion of said balloon lodges said stent in said body lumen with a hydrogel coated on an inner surface of the stent.
- 2. The assembly of claim-1, wherein said hydrogel is crosslinked.
- 3. The assembly of claim 1, wherein said hydrogel is selected from the group consisting of a polyacid, cellulosic polymer, collagen, gelatin, albumin, alginate, poly 2-hydroxyethyl methyl acrylate (HEMA), polyvinylpyrrolidone, maleic anhydride polymer, polyamide, polyacrylamide, polyvinyl alcohol, polyethylene glycol, and polyethylene oxide, and polysaccharide.
- 4. The assembly of claim 1, wherein said hydrogel is poly(acrylic acid).
- 5. The assembly of claim 4, wherein said poly(acrylic acid) is crosslinked.
- 6. The assembly of claim 1, wherein said hydrogel is hyaluronic acid.
- 7. The assembly of claim 6, wherein said hyaluronic acid is crosslinked.
- 8. The assembly of claim 1, wherein said hydrogel comprises a therapeutic agent.
- 9. The assembly of claim 8, wherein said therapeutic agent is an anti-thrombogenic agent.
- 10. The assembly of claim 9, wherein said antithrombogenic agent is selected from the group consisting of heparin, PPACK, enoxaprin, aspirin, and hirudin.
- 11. The assembly of claim 8, wherein said therapeutic agent inhibits platelet deposition.
- 12. The assembly of claim 8, wherein said therapeutic agent is a thrombolytic agent.
- 13. The assembly of claim 12, wherein said thrombolytic agent is selected from the group consisting of urokinase, streptokinase, and tissue plasminogen activator.
- 14. A catheter assembly for delivering an expansible stent to a body lumen and lining said stent with a hydrogel, comprising
(a) a catheter comprising a balloon and a delivery port for administering a hydrogel to an inner surface of said stent; and (b) said stent mounted on said balloon, said stent being in a contracted condition for passage with said catheter into said body lumen whereby expansion of said balloon lodges said stent in said body lumen, wherein said hydrogel is administered through said delivery port and deposited on an inner surface of said stent as a lining.
- 15. The assembly of claim 14, wherein said balloon comprises a first layer and a second outer aperatured layer overlying said delivery port, wherein said hydrogel is administered through said outer aperatured layer.
- 16. The assembly of claim 14, wherein said hydrogel comprises a therapeutic agent.
- 17. A method for lining a stent, comprising
(a) providing a catheter assembly comprising a balloon at least a portion of which is coated with a hydrogel, wherein an expansible stent is mounted on said balloon in a contracted condition, (b) introducing said assembly into a body lumen, and (c) inflating said balloon to lodge said stent in said body lumen and to release said hydrogel from said coated portion to an inner surface of said stent as a lining.
- 18. The method of claim 17, wherein said body lumen is a blood vessel.
- 19. The method of claim 18, wherein said vessel is an occluded artery.
- 20. The method of claim 17, wherein said hydrogel comprises a therapeutic agent.
- 21. A method of lining a stent positioned in a body lumen, comprising:
(a) providing a catheter comprising a balloon at least a portion of which is coated with a hydrogel, (b) introducing said catheter into said body lumen, (c) advancing said catheter in said body lumen until said coated portion is positioned proximate to an inner surface of said stent; and (d) inflating said balloon to release said hydrogel from said coated portion to said inner surface of said stent as a lining.
- 22. The method of claim 21, further comprising crosslinking said hydrogel.
- 23. The method of claim 21, wherein said catheter further comprises a sheath over said hydrogel.
- 24. The method of claim 23, comprising removing said sheath prior to inflating said balloon.
- 25. A method of lining a stent positioned in a body lumen, comprising
(a) providing a catheter comprising a balloon and a delivery port, wherein said balloon comprises a first layer and a second outer aperatured layer overlying said delivery port, (b) introducing said catheter into said body lumen, (c) advancing said catheter in said body lumen until said outer aperatured layer is positioned proximate to an inner surface of said stent; (d) delivering a hydrogel into a space between said first layer and said second outer aperatured layer, and (d) inflating said balloon to press said hydrogel through said outer aperatured layer, wherein said hydrogel is deposited on said inner surface of said stent as a lining.
- 26. The method of claim 25, further comprising crosslinking said hydrogel.
- 27. A method of selectively lining a permeable stent to treat an aneurism, comprising
(a) providing a catheter comprising a balloon at least a portion of which is coated with a hydrogel, (b) introducing said catheter into an aneurismal blood vessel comprising said permeable stent in the region of said aneurism, (c) advancing said catheter in said vessel until said coated portion is positioned proximate to said aneurism; and (d) inflating said balloon to release said hydrogel from said coated portion to an inner surface of said stent proximate to said aneurism to selectively line said stent, wherein said hydrogel renders said surface impermeable thereby reducing blood flow into said aneurism.
CROSS REFERENCE TO RELATED APPLICATIONS
[0001] This application is a continuation-in-part of application U.S. Ser. No. 08/097,248, filed Jul. 23, 1993, which is a continuation-in-part of application U.S. Ser. No. 07/795,976, filed Nov. 22, 1991, issued as U.S. Pat. No. 5,304,121, which is a continuation-in-part of application U.S. Ser. No. 07/635,732, filed Dec. 28, 1990, now abandoned. This application is also a continuation-in-part of application U.S. Ser. No. 08/507,844, filed Jul. 27, 1995, which is a continuation-in-part of U.S. Ser. No. 07/268,999, filed Jun. 30, 1994, issued as U.S. Pat. No. 5,439,446. The entire contents of each of these applications is hereby incorporated by reference.
Continuations (2)
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Number |
Date |
Country |
Parent |
09129280 |
Aug 1998 |
US |
Child |
10059420 |
Jan 2002 |
US |
Parent |
08717290 |
Sep 1996 |
US |
Child |
09129280 |
Aug 1998 |
US |
Continuation in Parts (5)
|
Number |
Date |
Country |
Parent |
08507844 |
Jul 1995 |
US |
Child |
08717290 |
Sep 1996 |
US |
Parent |
08268999 |
Jun 1994 |
US |
Child |
08507844 |
Jul 1995 |
US |
Parent |
07795976 |
Nov 1991 |
US |
Child |
08097248 |
Jul 1993 |
US |
Parent |
07635732 |
Dec 1990 |
US |
Child |
07795976 |
Nov 1991 |
US |
Parent |
07451507 |
Dec 1989 |
US |
Child |
07635732 |
Dec 1990 |
US |