Claims
- 1. A stent delivery system comprising:
a catheter; a balloon operably attached to the catheter; and a stent disposed on the balloon; a silane layer disposed on the stent; and a coating disposed on the silane layer.
- 2. The stent delivery system of claim 1 wherein the coating includes a therapeutic agent.
- 3. The stent delivery system of claim 1 wherein the coating is a polymer.
- 4. The stent delivery system of claim 1 wherein the silane layer is selected from the group consisting of a monolayer, a multilayer, and a bulk phase layer.
- 5. The stent delivery system of claim 1 wherein the stent is a stainless steel stent.
- 6. A coated stent comprising:
a stent; a silane layer disposed on the stent; and a coating disposed on the silane layer.
- 7. The coated stent of claim 6 wherein the coating includes a therapeutic agent.
- 8. The coated stent of claim 6 wherein the coating is a polymer.
- 9. The coated stent of claim 6 wherein the silane layer is selected from the group consisting of a monolayer, a multilayer, and a bulk phase layer.
- 10. The coated stent of claim 6 wherein the stent is a stainless steel stent.
- 11. A method for producing a stent comprising:
providing a stent; mixing silane with alcohol to form a silane solution; applying the silane solution to the stent; and curing the silane solution on the stent to form a silane layer.
- 12. The method of claim 11 further comprising applying a coating to the silane layer.
- 13. The method of claim 12 wherein the coating includes a therapeutic agent.
- 14. The method of claim 12 wherein the coating is a polymer.
- 15. The method of claim 11 wherein the stent is a stainless steel stent.
- 16. The method of claim 11 wherein the silane is an amino silane.
- 17. The method of claim 11 wherein the silane is selected from the group consisting of trimethoxysilylpropyl-diethylenetriamine; 3 aminopropyltrimethoxysilane; n-styrylmethyl 2 aminoethylamino propyl trimethoxysilane; vinyl trimethoxysilane; methacryloxypropyltrimethoxysilane; 3-(n-styrylmethyl-2-aminoethylaminopropyltrimethoxysilane); and 3 (glycidoxypropyl)-trimethoxysilane.
- 18. The method of claim 11 wherein the alcohol is selected from the group consisting of isopropyl alcohol, methyl alcohol, and ethyl alcohol.
- 19. The method of claim 11 wherein mixing silane with alcohol to form a silane solution further comprises mixing silane with alcohol to form a silane solution of about 2 to 30% silane.
- 20. The method of claim 11 wherein mixing silane with alcohol to form a silane solution further comprises mixing silane with alcohol to form a silane solution of about 5% silane.
- 21. The method of claim 11 wherein applying the silane solution to the stent further comprises dipping the stent in the silane solution.
- 22. The method of claim 11 wherein applying the silane solution to the stent further comprises spraying the stent with the silane solution.
- 23. The method of claim 11 wherein applying the silane solution to the stent further comprises applying the silane solution at a temperature between about 20 to 70 deg.C for a time of between about 1 and 60 minutes.
- 24. The method of claim 11 wherein applying the silane solution to the stent further comprises applying the silane solution at a temperature of about 35 deg.C for a time of about 15 minutes.
- 25. The method of claim 11 wherein curing the silane solution on the stent to form a silane layer further comprises curing the silane solution in an inert atmosphere.
- 26. The method of claim 11 wherein curing the silane solution on the stent to form a silane layer further comprises curing the silane solution at a temperature between about 25 to 115 degrees C. for a time of between about 1 to 24 hours.
- 27. The method of claim 11 wherein curing the silane solution on the stent to form a silane layer further comprises curing the silane solution at a temperature of about 60 degrees C. for a time of about 3 to 15 hours.
- 28. A system for producing a stent comprising:
means for providing a stent; means for mixing silane with alcohol to form a silane solution; means for applying the silane solution to the stent; and means for curing the silane solution on the stent to form a silane layer.
- 29. The system of claim 28 further comprising means for applying a coating to the silane layer.
- 30. The system of claim 28 wherein means for applying the silane solution to the stent further comprises means for dipping the stent in the silane solution.
- 31. The system of claim 28 wherein means for applying the silane solution to the stent further comprises means for spraying the stent with the silane solution.
- 32. The system of claim 28 wherein the means for curing the silane solution on the stent to form a silane layer further comprises means for curing the silane solution in an inert atmosphere.
- 33. A coated stent comprising:
a stainless steel stent; an amino silane layer disposed on the stainless steel stent; a polymer coating disposed on the amino silane layer, the polymer coating including a therapeutic agent.
RELATED APPLICATION
[0001] This application claims priority to U.S. Provisional Application No. 60/464,440, “Stent with Improved Surface Adhesion” to Rangarajan Sundar, filed Apr. 22, 2003, the entirety of which is incorporated by reference.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60464440 |
Apr 2003 |
US |