Claims
- 1. A compound of the formula ##STR45## wherein W is CH.sub.2 COOH, CH.sub.2 COOR or hydrogen, R is straight or branched chain lower alkyl having from 1 to 4 carbon atoms, Z is hydrogen or straight chain lower alkyl having from 1 to 4 carbon atoms and X.sub.1 is methylene, carbonyl, hydroxymethylene, thio, blocked carbonyl, wherein blocked carbonyl is selected from the group consisting of C.sub.2-3 alkylene ketal and C.sub.1-4 dialkyl hydrazone, or blocked hydroxymethylene, wherein the hydroxy blocking group is selected from the group consisting of benzyl, methyl, tertiary butoxy carbonyl, C.sub.1-4 trialkylsilyl, methoxymethyl, (2-methoxyethoxy)methyl and tetrahydropyranyl, sulfinyl or sulfonyl, with the proviso that when X is sulfinyl or sulfonyl, Z is other than H, or X.sub.1 and Z, taken together, are methylidenyl, R.sub.a is hydrogen, halogen or protected hydroxy and R.sub.b is hydrogen or R.sub.a and R.sub.b are protected hydroxy, wherein protected hydroxy comprises a hydroxy moiety blocked by a hydroxy blocking group selected from the group defined above, and B.sub.t is a C.sub.4-5 tertiary-alkoxycarbonyl blocking group, with the proviso that when W is hydrogen and X.sub.1 is methylene, R.sub.a is halogen and with the additional proviso that when W is hydrogen and X.sub.1 and Z, taken together, are methylidenyl, R.sub.a is other than hydrogen.
- 2. A compound of claim 1 wherein X.sub.1 is methylene.
- 3. A compound of claim 1 wherein X.sub.1 is carbonyl.
- 4. A compound of claim 1 wherein X.sub.1 is hydroxymethylene.
- 5. A compound of claim 1 wherein Z is hydrogen.
- 6. A compound of claim 1 wherein W is hydrogen.
Parent Case Info
This is a divisional of application Ser. No. 130,431, filed Mar. 14, 1980, now U.S. Pat. No. 4,341,698, which is a continuation-in-part of application Ser. No. 50,950, filed June 21, 1979, abandoned.
US Referenced Citations (3)
Foreign Referenced Citations (1)
Number |
Date |
Country |
2438619A |
Feb 1976 |
DEX |
Non-Patent Literature Citations (2)
Entry |
Moureu et al., "Bull. Soc. Chim., France", 1956, pp. 1785-1787. |
Saikawa et al., "Chemical Abstracts", vol. 89, 1976, col. 89:75453w. |
Divisions (1)
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Number |
Date |
Country |
Parent |
130431 |
Mar 1980 |
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Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
50950 |
Jun 1979 |
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