Claims
- 1. A phenylacetic acid amide compound of the formula ##STR14## in which each of R.sub.1 and R.sub.2 is hydrogen, lower alkyl, lower alkoxy, halogen having an atomic number of not more than 35 or trifluoromethyl, each of R.sub.3 and R.sub.4 is hydrogen, lower alkyl, lower alkoxy or halogen having an atomic number of not more than 35, R.sub.5 is lower alkylene or lower alkylidene, R.sub.6 is carboxy, lower alkoxycarbonyl, phenyl-lower alkoxycarbonyl or aminocarbonyl, R.sub.7 is hydrogen, and the group of the formula --C(.dbd.O)--R.sub.8 is carboxyl, lower alkoxycarbonyl, or substituted carbamoyl of the formula
- --C(.dbd.O)--N(R.sub.7.sup.a)--R.sub.5.sup.a (R.sub.6.sup.a)--C(.dbd.O)--R.sub.8.sup.a
- in which R.sub.5.sup.a is lower alkylene or lower alkylidene, R.sub.6.sup.a is phenyl or phenyl substituted by hydroxy, R.sub.7.sup.a is hydrogen and R.sub.8.sup.a is carboxy or lower alkoxycarbonyl, wherein the radical of the formula --NR.sub.7 --R.sub.5 (R.sub.6)--CO--R.sub.8 has the L-configuration, or a therapeutically acceptable salt thereof.
- 2. A compound of the formula I according to claim 1, in which R.sub.1 is hydrogen, lower alkyl having not more than 4 carbon atoms, lower alkoxy having not more than 4 carbon atoms, halogen having an atomic number of not more than 35, or trifluoromethyl and R.sub.2, R.sub.3 and R.sub.4 are each hydrogen, lower alkyl having not more than 4 carbon atoms, lower alkoxy having not more than 4 carbon atoms or halogen having an atomic number of not more than 35 and in which R.sub.5 is lower alkylene or lower alkylidene having not more than 7 carbon atoms, R.sub.6 is carboxyl, lower alkoxycarbonyl having not more than 4 carbon atoms in the lower alkoxy moiety, or carbamoyl, and the group of the formula --C(.dbd.O)--R.sub.8 (Ia) is carboxyl, lower alkoxycarbonyl having not more than 4 carbon atoms in the lower alkoxy moiety.
- 3. A compound as claimed in claim 1 of the formula ##STR15## in which R.sub.1 ' is lower alkyl having not more than 4 carbon atoms or halogen having an atomic number of not more than 35, R.sub.2 ' is hydrogen, lower alkyl having not more than 4 carbon atoms or halogen having an atomic number of not more than 35 and R.sub.3 ' is hydrogen, with the proviso that R.sub.3 ' can also be lower alkyl having not more than 4 carbon atoms in the 3-position, if R.sub.1 ' is one of the said halogen atoms and R.sub.2 ' is hydrogen, or with the proviso that R.sub.3 ' can also be halogen having an atomic number of not more than 35, in the 4-position, if R.sub.1 ' is one of the said halogen atoms and R.sub.2 ' is hydrogen, and R.sub.5 ' is lower alkyl having not more than 4 carbon atoms, which is substituted by carboxyl, lower alkoxycarbonyl having not more than 4 carbon atoms in the lower alkoxy moiety, and R.sub.8 ' is hydroxyl or lower alkoxy having not more than 4 carbon atoms, or a therapeutically acceptable salt thereof.
- 4. A compound according to claim 3, in which R.sub.1 ' and R.sub.2 ' are each chlorine and R.sub.3 ' is hydrogen, or R.sub.1 ' is chlorine, R.sub.2 ' is hydrogen and R.sub.3 ' is methyl in the 3-position or chlorine in the 4-position, and R.sub.5 ' is lower alkyl having not more than 4 carbon atoms which is substituted by carboxyl or lower alkoxycarbonyl having not more than 4 carbon atoms in the lower alkoxy moiety, and R.sub.8 ' is hydroxyl or lower alkoxy or a therapeutically acceptable salt thereof.
- 5. A compound according to claim 1 which is L-(+)-N-[[2-(2,6-dichlorophenylamino)-phenyl]-acetyl]-glutamic acid or a therapeutically acceptable salt thereof.
- 6. A compound according to claim 1 which is dimethyl L-(+)-N-[[2-(2,6-dichlorophenylamino)-phenyl]-acetyl]-aspartate.
- 7. A compound according to claim 1 which is L-(+)-N-[[2-(2,6-dichlorophenylamino)-phenyl]-acetyl]-aspartic acid or a therapeutically acceptable salt thereof.
- 8. A compound according to claim 1 which is the methyl ester of N-[[2-(2,6-dichlorophenylamino)-phenyl]-acetyl]-L-beta-tert.butyl-asparaginyl-L-phenylalanine.
- 9. A compound according to claim 1 which is N-[[2-(2,6-dichlorophenylamino)-phenyl]-acetyl]-L-asparaginyl-L-phenylalanine or a therapeutically acceptable salt thereof.
- 10. A pharmaceutical preparation containing an antiinflammatory effective amount of a compound as claimed in claim 1 together with conventional pharmaceutical excipients.
Priority Claims (2)
Number |
Date |
Country |
Kind |
77316 |
May 1977 |
LUX |
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78106 |
Sep 1977 |
LUX |
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CROSS REFERENCE
This is a divisional of application Ser. No. 033,295, filed on Apr. 25, 1979 now U.S. Pat. No. 4,250,192, which is a continuation of our copending applications Ser. No. 905,087, filed May 11, 1978, now abandoned, and Ser. No. 906,292, filed May 15, 1978, now abandoned.
US Referenced Citations (3)
Number |
Name |
Date |
Kind |
3536758 |
Sallmann et al. |
Oct 1970 |
|
3652762 |
Sallmann |
Mar 1972 |
|
3897782 |
Baltze et al. |
Jul 1975 |
|
Related Publications (1)
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Number |
Date |
Country |
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906292 |
May 1978 |
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Divisions (1)
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Number |
Date |
Country |
Parent |
33295 |
Apr 1979 |
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Continuations (1)
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Number |
Date |
Country |
Parent |
905087 |
May 1978 |
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