Claims
- 1. A method for the production of a calcium phosphate biomaterial powder, the method comprising:
(a) mixing a silica colloid with a calcium phosphate colloidal suspension; (b) spray drying (a) into powder; (c) sintering said powder.
- 2. The method of claim 1, wherein said silica colloid is finely divided fumed silica colloid.
- 3. The method of claim 2, wherein said calcium phosphate colloidal suspension is precipitated from a mixture of calcium nitrate tetrahydrate and ammonium dihydrogen orthophosphate.
- 4. The method of claim 3, wherein sintering is conducted using a heating profile with a ramp rate of about 5° C./minute, drying at about 200° C. for about 180 minutes, calcining at about 550° C. for about 60 minutes, and sintering at about 1000° C. for about 60 minutes.
- 5. The method of claim 4, wherein said powder is formed into three dimensional pieces.
- 6. The method of claim 5, wherein said powder has up to about 10 weight percent of silicon.
- 7. A powdered calcium phosphate biomaterial produced by the method of claim 1.
- 8. A method for the production of a calcium phosphate biomaterial powder, the method comprising:
(a) mixing a solution of calcium nitrate tetrahydrate with a solution of ammonium dihydrogen orthophosphate to produce a calcium phosphate colloidal suspension; (b) mixing (a) with a finely divided fumed silica colloid; (c) spray drying (b) into a powder; and (d) sintering using a heating profile with a ramp rate of about 5° C. per minute, drying at about 200° C. for about 180 minutes, calcining at about 550° C. for about 60 minutes and sintering at about 1000° C. for about 60 minutes.
- 9. A powdered calcium phosphate biomaterial produced by the method of claim 8.
- 10. The method of claim 8, wherein said calcium phosphate colloidal suspension is centrifuged to reduce the volume prior to the addition of said finely divided fumed silica colloid.
- 11. The method of claim 2 or 8, wherein said finely divided silica colloid has a particle size of about 10-100 nm.
RELATED APPLICATIONS
[0001] This application is a continuation-in-part of co-pending U.S. divisional application U.S. Ser. No. 09/971,148, filed Oct. 4, 2001, which is a divisional of U.S. Ser. No. 09/044,749, filed Mar. 19, 1998, issued as U.S. Pat. No. 6,323,146 which is a continuation-in-part of co-pending U.S. patent application Ser. No. 09/029,872 filed Mar. 2, 1998, which is a U.S. national phase application of PCT/CA96/00585, filed Aug. 30, 1996, which is a continuation-in-part of U.S. Ser. No. 08/576,238, filed Dec. 21, 1995, now abandoned, which claims the benefit of U.S. Provisional Application Serial No. 60/003,157, filed Sep. 1, 1995, which are each hereby incorporated herein in their entirety by reference.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60003157 |
Sep 1995 |
US |
Divisions (1)
|
Number |
Date |
Country |
Parent |
09044749 |
Mar 1998 |
US |
Child |
09971148 |
Oct 2001 |
US |
Continuation in Parts (3)
|
Number |
Date |
Country |
Parent |
09971148 |
Oct 2001 |
US |
Child |
10142151 |
May 2002 |
US |
Parent |
09029872 |
Jun 1998 |
US |
Child |
09044749 |
Mar 1998 |
US |
Parent |
08576238 |
Dec 1995 |
US |
Child |
PCT/CA96/00585 |
Aug 1996 |
US |