This application is a Section 371 of International Application No. PCT/IL2017/050903, filed Aug. 16, 2017, which was published in the English language on Mar. 1, 2018 under International Publication No. WO 2018/037398 A1, which claims priority under 35 U.S.C. § 119 to Israeli Patent Application No. 247376, filed on Aug. 21, 2016, the disclosures of which are incorporated herein by reference.
The invention relates to syringe assemblies.
Pre-filled syringes containing a liquid drug dosage ready for immediate administration can be equipped with either an integral standard intramuscular needle for intramuscular injection to a depth of about 1 cm or an integral intradermal micro-needle for intradermal injection to a depth of about 2-3 mm. Alternatively, pre-filled syringes can have a widened distal syringe tip preventing the attachment of a standard Luer connector needle hub and intended for oral administration of a liquid drug dosage. Pre-filled needle-equipped syringes have dead volumes considerably smaller than a standard Luer connector dead volume of about 0.03 ml to 0.05 ml which for certain vaccines is comparable to a vaccine dosage which can lead to considerable waste of vaccine.
Pre-filled syringes are filled with a liquid drug dosage as part of a manufacturing process for manufacturing same. Syringes with integral needles or a widened distal syringe tip can be filled with a liquid drug dosage by a clinical practitioner prior to use but such a manual filling process is generally regarded as time consuming and problematic. PCT International Application No. PCT/GB2014/051256 entitled Syringes and published under PCT International Publication No. WO 2014/174278 discloses a syringe assembly for assisting filling an initially empty syringe with a liquid drug dosage from a drug vial containing the liquid drug dosage.
There is a need for syringe assemblies including a syringe with an integral liquid drug administration device which can be readily filled with liquid drug contents immediately before use.
The present invention is directed toward syringe assemblies including a syringe pre-equipped with an integral liquid drug administration device and a drug vial adapter. The integral liquid drug administration device can be a standard intramuscular needle, a standard intradermal micro-needle, a widened distal syringe tip, and the like. The drug vial adapter is initially mounted on the syringe and intended to be manually detached therefrom to expose the integral liquid drug administration device for enabling administration of liquid drug contents. The syringe includes a flow control member having an initial flow path position for enabling manual filling the syringe with liquid drug contents from a drug vial and a final flow path position for enabling manual administration of liquid drug contents. Detachment of the drug vial adapter from the syringe urges the flow control member from its initial flow path position to its final flow path position. Detachment of the drug vial adapter from the syringe can be either by manual rotation or linear detachment of the drug vial adapter relative to the syringe.
The syringe assemblies of the present invention are preferably supplied with an empty syringe. A syringe assembly can be used with a drug vial containing liquid drug contents ready for immediate aspiration to an empty syringe. In the case of a drug vial containing powder medicament, a syringe assembly can preferably additionally include a liquid vial adapter for telescopic mounting on a liquid vial containing liquid contents for mixing with the powder medicament. The liquid contents can be diluent only for reconstitution or can include an active component. Such a syringe assembly employs its initial flow path position for three liquid transfers as follows: First liquid transfer for aspirating liquid contents from the liquid vial to the empty syringe. The liquid vial adapter and its empty liquid vial are necessarily detached from the syringe assembly after the first liquid transfer to enable telescopic mounting on a drug vial containing the power medicament. Second liquid transfer for injecting the liquid contents from the syringe into the drug vial to form the liquid drug contents. And third liquid transfer for aspirating the liquid drug contents from the drug vial into the empty syringe.
In order to understand the invention and to see how it can be carried out in practice, preferred embodiments will now be described, by way of non-limiting examples only, with reference to the accompanying drawings in which similar parts are likewise numbered, and in which:
The syringe assembly 100A has a longitudinal syringe assembly centerline 101 and includes a syringe 102 having a proximal syringe end 103 and a distal syringe tip 104, and a drug vial adapter 106. The syringe 102 includes an open-ended syringe barrel 107 having a proximal syringe barrel end 107A, a distal syringe barrel end 107B and a syringe barrel interior 108. The syringe 102 includes a plunger 109 with a thumb stop 111. The proximal syringe end 103 has a diametric pair of fingers grips 112. The distal syringe tip 104 is formed with an annular flange 113 transverse to the longitudinal syringe assembly centerline 101. The annular flange 113 is formed with an external screw thread 114. The distal syringe tip 104 is formed with a transverse directed lumen 116 extending between the distal syringe barrel end 107B and an aperture 117 formed distal to the annular flange 113 with respect to the proximal syringe end 103A.
The distal syringe tip 104 has a liquid drug dispensing lumen 119 co-axial with the longitudinal syringe assembly centerline 101. The liquid drug dispensing lumen 119 is fitted with an integral liquid drug administration device 121 constituted by a standard intradermal needle. The distal syringe tip 104 has a conical peripheral syringe tip surface 122 tapering from the distal syringe barrel end 107B towards the intradermal needle 121. The distal syringe tip 104 has a transverse directed lumen 123 spaced apart from the transverse directed lumen 116. The transverse directed lumen 123 extends between the liquid drug dispensing lumen 119 and an aperture 124 in the peripheral distal syringe tip surface 122. The two transverse directed lumens 116 and 123 lie on a longitudinal plane passing through the longitudinal syringe assembly centerline 101.
The syringe 102 includes a flow control member 126 having a tubular construction for snugly nesting between the distal syringe tip 104 and the drug vial adapter 106. The flow control member 126 has a proximal topside 127 and a distal underside 128. The flow control member 126 has a conical throughgoing bore 129 with an internal flow control member surface 131 in sealed contact with the peripheral distal syringe tip surface 122. The underside 128 is formed with a diametric pair of recesses 132A and 132B. The flow control member 126 has a diametric pair of flow channels for flow communication with the transverse directed lumen 116 for corresponding use in two flow path positions as follows: A longitudinal directed lumen 133 offset to the longitudinal syringe assembly centerline 101 for use in an initial flow path position. The lumen 133 extends between an aperture 134 formed in the internal flow control member surface 131 and the recess 132A. And a groove 136 formed in the internal flow control member surface 131 for flow communication between the two transverse directed lumens 116 and 123 in a final flow path position. The groove 136 has a proximal groove end 137 and a distal groove end 138. The aperture 134 and the proximal groove end 137 are diametric opposite on the same plane transverse to the longitudinal syringe assembly centerline 101.
The drug vial adapter 106 has a tubular construction and includes a proximal upright stem 139, a distal downward depending skirt 141 for telescopic mounting on the drug vial 10 and an intermediate neck 142 between the upright stem 139 and the downward depending skirt 141. The upright stem 139 has diametric pair of inward directed screw thread protrusions 143 for screw thread mounting on the external screw thread 114. The drug vial adapter 106 requires a half turn to detach from the distal syringe tip 104 and concurrently rotate the flow control member 126 from its initial flow path position to its final flow path position. The upright stem 139 and the intermediate neck 142 enclose the distal syringe tip 104 and the flow control member 126. The skirt 141 includes a diametric pair of longitudinal directed apertures 144 having inward directed protrusions 146 for snap fitting on the drug vial crown 13 and a puncturing cannula 147 with a puncturing cannula tip 147A for puncturing the drug vial stopper 18 on snap fitting on the drug vial 10. The neck 142 includes a diametric pair of protrusions 148A and 148B for corresponding snug insertion in the diametric pair of recesses 132A and 132B. The puncturing cannula 147 includes a lumen 149 extending between an aperture 151 in the protrusion 148A and an aperture 152 at the puncturing cannula tip 147A.
The distal syringe tip 104 is formed with a transverse throughgoing bore 161 transverse to the longitudinal syringe assembly centerline 101. The distal syringe tip 104 includes a lumen 162 co-axial with the longitudinal syringe assembly centerline 101 and in flow communication with a proximal side of the transverse throughgoing bore 161. The distal syringe tip 104 includes a liquid drug dispensing lumen 163 co-axial with the longitudinal syringe assembly centerline 101 and in flow communication with a distal side of the transverse throughgoing bore 161. The liquid drug dispensing lumen 163 is fitted with an intradermal needle 121.
The syringe 102 includes a generally tubular flow control member 164 with a sealed end 166. The flow control member 164 includes a peripheral flow control member surface 167 having a transverse flat cutout 168 and a peripheral groove 169. The flat cutout 168 has a first cutout end 171 and a second cutout end 172. The peripheral groove 169 is in flow communication with the second cutout end 172.
The drug vial adapter 106 includes an internal semi-circular cam surface 173 contacting the sealed end 166. The cam surface 173 has a start cam surface end 174 and a final cam surface end 176. The start cam surface end 174 has a separation S1 from the longitudinal syringe assembly centerline 101. The final cam surface end 176 has a separation S2 from the longitudinal syringe assembly centerline 101. The separation S1 is greater than the separation S2 such that rotation of the drug vial adapter 106 urges the flow control member 164 from an initial flow path position to a final flow path position.
The syringe assembly 100D additionally includes a liquid vial adapter 180 for telescopic mounting on the liquid vial 30. The liquid vial adapter 180 has a transverse liquid vial adapter top wall 181 formed with a downward depending skirt 182 for telescopic mounting on the liquid vial 30. The liquid vial adapter 180 is formed with a diametric pair of clips 183 for clipping inside the diametric pair of longitudinal directed apertures 144 for mounting the liquid vial adapter 180 on the drug vial adapter 106. The clips 183 have downward depending finger operated release members 184 for releasing the liquid vial adapter 180 from the drug vial adapter 106 on applying a compression force thereon towards the longitudinal syringe assembly centerline 101. The liquid vial adapter top wall 181 is formed with an upright conical shaped port 186 for receiving the puncturing cannula 147. The liquid vial adapter top wall 181 is formed with a downward depending puncturing cannula 187 for puncturing the liquid vial 30 on telescopic mounting the liquid vial adapter 180 thereon. The port 186 is in continuous flow communication with the puncturing cannula 187 thereby affording flow communication between the syringe 102 and the puncturing cannula 187 in the initial flow path position of the flow control member 164.
While the invention has been described with respect to a limited number of embodiments, it will be appreciated that many variations, modifications, and other applications of the invention can be made within the scope of the appended claims.
Number | Date | Country | Kind |
---|---|---|---|
247376 | Aug 2016 | IL | national |
Filing Document | Filing Date | Country | Kind |
---|---|---|---|
PCT/IL2017/050903 | 8/16/2017 | WO | 00 |
Publishing Document | Publishing Date | Country | Kind |
---|---|---|---|
WO2018/037398 | 3/1/2018 | WO | A |
Number | Name | Date | Kind |
---|---|---|---|
62333 | Holl | Feb 1867 | A |
247975 | Wickes | Oct 1881 | A |
254444 | Vogel | Feb 1882 | A |
300060 | Ford | Jun 1884 | A |
1021681 | Jennings | Mar 1912 | A |
1704817 | Ayers | Mar 1929 | A |
1930944 | Schmitz, Jr. | Oct 1933 | A |
2326490 | Perelson | Aug 1943 | A |
2560162 | Garwood | Jul 1951 | A |
2748769 | Huber | Jun 1956 | A |
2830587 | Everett | Apr 1958 | A |
2931668 | Baley | Apr 1960 | A |
2968497 | Treleman | Jan 1961 | A |
3059643 | Barton | Oct 1962 | A |
D198499 | Harautuneian | Jun 1964 | S |
3225763 | Waterman | Dec 1965 | A |
3277893 | Clark | Oct 1966 | A |
3308822 | De Luca | Mar 1967 | A |
3484849 | Huebner et al. | Dec 1969 | A |
3618637 | Santomieri | Nov 1971 | A |
3684992 | Huguet et al. | Aug 1972 | A |
3752598 | Bowers et al. | Aug 1973 | A |
3757981 | Harris, Sr. et al. | Sep 1973 | A |
3782365 | Pinna | Jan 1974 | A |
3788524 | Davis et al. | Jan 1974 | A |
3822700 | Pennington | Jul 1974 | A |
3826261 | Killinger | Jul 1974 | A |
3872992 | Larson | Mar 1975 | A |
3885607 | Peltier | May 1975 | A |
3938520 | Scislowicz et al. | Feb 1976 | A |
3957052 | Topham | May 1976 | A |
3977555 | Larson | Aug 1976 | A |
3993063 | Larrabee | Nov 1976 | A |
4020839 | Klapp | May 1977 | A |
4026128 | Blanco | May 1977 | A |
4051852 | Villari | Oct 1977 | A |
D247975 | Luther | May 1978 | S |
D248568 | Ismach | Jul 1978 | S |
4109670 | Slagel | Aug 1978 | A |
4121585 | Becker, Jr. | Oct 1978 | A |
4161178 | Genese | Jul 1979 | A |
4187848 | Taylor | Feb 1980 | A |
D254444 | Levine | Mar 1980 | S |
4203067 | Fitzky et al. | May 1980 | A |
4203443 | Genese | May 1980 | A |
4210173 | Choksi et al. | Jul 1980 | A |
D257286 | Folkman | Oct 1980 | S |
4253501 | Ogle | Mar 1981 | A |
4296786 | Brignola | Oct 1981 | A |
4303067 | Connolly et al. | Dec 1981 | A |
4312349 | Cohen | Jan 1982 | A |
4314586 | Folkman | Feb 1982 | A |
4328802 | Curley et al. | May 1982 | A |
4335717 | Bujan et al. | Jun 1982 | A |
D267199 | Koenig | Dec 1982 | S |
4376634 | Prior et al. | Mar 1983 | A |
D268871 | Benham et al. | May 1983 | S |
4392850 | Elias | Jul 1983 | A |
D270282 | Gross | Aug 1983 | S |
4410321 | Pearson et al. | Oct 1983 | A |
4411662 | Pearson | Oct 1983 | A |
D271421 | Fetterman | Nov 1983 | S |
4434823 | Hudspith | Mar 1984 | A |
4465471 | Harris et al. | Aug 1984 | A |
4475915 | Sloane | Oct 1984 | A |
4493348 | Lemmons | Jan 1985 | A |
4505709 | Froning et al. | Mar 1985 | A |
4507113 | Dunlap | Mar 1985 | A |
D280018 | Scott | Aug 1985 | S |
4532969 | Kwaan | Aug 1985 | A |
4564054 | Gustavsson | Jan 1986 | A |
4573993 | Hoag et al. | Mar 1986 | A |
4576211 | Valentini et al. | Mar 1986 | A |
4581014 | Millerd et al. | Apr 1986 | A |
4585446 | Kempf | Apr 1986 | A |
4588396 | Stroebel et al. | May 1986 | A |
4588403 | Weiss et al. | May 1986 | A |
D284603 | Loignon | Jul 1986 | S |
4604093 | Brown et al. | Aug 1986 | A |
4607671 | Aalto et al. | Aug 1986 | A |
4614437 | Buehler | Sep 1986 | A |
4638975 | Iuchi et al. | Jan 1987 | A |
4639019 | Mittleman | Jan 1987 | A |
4667927 | Oscarsson | May 1987 | A |
4675020 | McPhee | Jun 1987 | A |
4676530 | Nordgren et al. | Jun 1987 | A |
4683975 | Booth et al. | Aug 1987 | A |
4697622 | Swift et al. | Oct 1987 | A |
4721133 | Sundblom | Jan 1988 | A |
4729401 | Raines | Mar 1988 | A |
4735608 | Sardam | Apr 1988 | A |
4743229 | Chu | May 1988 | A |
4743243 | Vaillancourt | May 1988 | A |
4752292 | Lopez et al. | Jun 1988 | A |
4758235 | Tu | Jul 1988 | A |
4759756 | Forman et al. | Jul 1988 | A |
4778447 | Velde et al. | Oct 1988 | A |
4787898 | Raines | Nov 1988 | A |
4797898 | Martinez | Jan 1989 | A |
D300060 | Molgaard-Nielsen | Feb 1989 | S |
4804366 | Zdeb et al. | Feb 1989 | A |
4826492 | Magasi | May 1989 | A |
4832690 | Kuu | May 1989 | A |
4834152 | Howson et al. | May 1989 | A |
D303013 | Konopka | Aug 1989 | S |
4857062 | Russell | Aug 1989 | A |
4865592 | Rycroft | Sep 1989 | A |
4871463 | Taylor et al. | Oct 1989 | A |
4898209 | Zbed | Feb 1990 | A |
4909290 | Coccia | Mar 1990 | A |
4919596 | Slate et al. | Apr 1990 | A |
4927423 | Malmborg | May 1990 | A |
4931040 | Haber et al. | Jun 1990 | A |
4932944 | Jagger et al. | Jun 1990 | A |
4967797 | Manska | Nov 1990 | A |
D314050 | Sone | Jan 1991 | S |
D314622 | Andersson et al. | Feb 1991 | S |
4997430 | Van der Heiden et al. | Mar 1991 | A |
5006114 | Rogers et al. | Apr 1991 | A |
5035686 | Crittenden et al. | Jul 1991 | A |
5041105 | D'Alo et al. | Aug 1991 | A |
5045066 | Scheuble et al. | Sep 1991 | A |
5049129 | Zdeb et al. | Sep 1991 | A |
5053015 | Gross | Oct 1991 | A |
5061248 | Sacco | Oct 1991 | A |
5088996 | Kopfer et al. | Feb 1992 | A |
5096575 | Cosack | Mar 1992 | A |
5104387 | Pokorney et al. | Apr 1992 | A |
5113904 | Aslanian | May 1992 | A |
5122124 | Novacek et al. | Jun 1992 | A |
5125908 | Cohen | Jun 1992 | A |
5125915 | Berry et al. | Jun 1992 | A |
D328788 | Sagae et al. | Aug 1992 | S |
5171230 | Eland et al. | Dec 1992 | A |
5201705 | Berglund et al. | Apr 1993 | A |
5201717 | Wyatt et al. | Apr 1993 | A |
5203771 | Melker et al. | Apr 1993 | A |
5203775 | Frank et al. | Apr 1993 | A |
5211638 | Dudar et al. | May 1993 | A |
5232029 | Knox et al. | Aug 1993 | A |
5232109 | Tirrell et al. | Aug 1993 | A |
5242432 | DeFrank | Sep 1993 | A |
5247972 | Tetreault | Sep 1993 | A |
D341420 | Conn | Nov 1993 | S |
5269768 | Cheung | Dec 1993 | A |
5270219 | DeCastro et al. | Dec 1993 | A |
5279576 | Loo et al. | Jan 1994 | A |
5288290 | Brody | Feb 1994 | A |
5300034 | Behnke et al. | Apr 1994 | A |
5301685 | Guirguis | Apr 1994 | A |
5304163 | Bonnici et al. | Apr 1994 | A |
5304165 | Haber et al. | Apr 1994 | A |
5308483 | Sklar et al. | May 1994 | A |
5312377 | Dalton | May 1994 | A |
5328474 | Raines | Jul 1994 | A |
D349648 | Tirrell et al. | Aug 1994 | S |
5334163 | Sinnett | Aug 1994 | A |
5334179 | Poll et al. | Aug 1994 | A |
5342346 | Honda et al. | Aug 1994 | A |
5344417 | Wadsworth, Jr. | Sep 1994 | A |
5348544 | Sweeney et al. | Sep 1994 | A |
5348548 | Meyer et al. | Sep 1994 | A |
5350372 | Ikeda et al. | Sep 1994 | A |
5364386 | Fukuoka et al. | Nov 1994 | A |
5364387 | Sweeney | Nov 1994 | A |
5374264 | Wadsworth, Jr. | Dec 1994 | A |
5385547 | Wong et al. | Jan 1995 | A |
5397303 | Sancoff et al. | Mar 1995 | A |
D357733 | Matkovich | Apr 1995 | S |
5429614 | Fowles et al. | Jul 1995 | A |
5433330 | Yatsko et al. | Jul 1995 | A |
5445630 | Richmond | Aug 1995 | A |
5445631 | Uchida | Aug 1995 | A |
D362718 | Deily et al. | Sep 1995 | S |
5451374 | Molina | Sep 1995 | A |
5454805 | Brony | Oct 1995 | A |
5464111 | Vacek et al. | Nov 1995 | A |
5464123 | Scarrow | Nov 1995 | A |
5466219 | Lynn et al. | Nov 1995 | A |
5466220 | Brenneman | Nov 1995 | A |
5470327 | Helgren et al. | Nov 1995 | A |
5471994 | Guirguis | Dec 1995 | A |
5472022 | Michel et al. | Dec 1995 | A |
5478337 | Okamoto et al. | Dec 1995 | A |
5482446 | Williamson et al. | Jan 1996 | A |
5492147 | Challender et al. | Feb 1996 | A |
5496274 | Graves et al. | Mar 1996 | A |
D369406 | Niedospial et al. | Apr 1996 | S |
5505714 | Dassa et al. | Apr 1996 | A |
5509433 | Paradis | Apr 1996 | A |
5515871 | Bittner et al. | May 1996 | A |
5520659 | Hedges | May 1996 | A |
5526853 | McPhee et al. | Jun 1996 | A |
5527306 | Raining | Jun 1996 | A |
5531695 | Swisher | Jul 1996 | A |
5547471 | Thompson et al. | Aug 1996 | A |
5549577 | Siegel et al. | Aug 1996 | A |
5554128 | Hedges | Sep 1996 | A |
5562686 | Sauer et al. | Oct 1996 | A |
5562696 | Nobles et al. | Oct 1996 | A |
5566729 | Grabenkort et al. | Oct 1996 | A |
5569191 | Meyer | Oct 1996 | A |
5573281 | Keller | Nov 1996 | A |
5578015 | Robb | Nov 1996 | A |
5583052 | Portnoff et al. | Dec 1996 | A |
5584819 | Kopfer | Dec 1996 | A |
5591143 | Trombley, III et al. | Jan 1997 | A |
5603706 | Wyatt et al. | Feb 1997 | A |
5607439 | Yoon | Mar 1997 | A |
5611576 | Guala | Mar 1997 | A |
5616203 | Stevens | Apr 1997 | A |
5636660 | Pfleiderer et al. | Jun 1997 | A |
5637101 | Shillington | Jun 1997 | A |
5641010 | Maier | Jun 1997 | A |
5645538 | Richmond | Jul 1997 | A |
5647845 | Haber et al. | Jul 1997 | A |
5651776 | Appling et al. | Jul 1997 | A |
5653686 | Coulter et al. | Aug 1997 | A |
5658133 | Anderson et al. | Aug 1997 | A |
5672160 | Osterlind et al. | Sep 1997 | A |
5674195 | Truthan | Oct 1997 | A |
5676346 | Leinsing | Oct 1997 | A |
5685845 | Grimard | Nov 1997 | A |
D388172 | Cipes | Dec 1997 | S |
5695829 | Quincy, III et al. | Dec 1997 | A |
5699821 | Paradis | Dec 1997 | A |
5702019 | Grimard | Dec 1997 | A |
5718346 | Weiler | Feb 1998 | A |
5728087 | Niedospial, Jr. | Mar 1998 | A |
D393722 | Fangrow, Jr. et al. | Apr 1998 | S |
5738144 | Rogers | Apr 1998 | A |
5743312 | Pfeifer et al. | Apr 1998 | A |
5746733 | Capaccio et al. | May 1998 | A |
5752942 | Doyle et al. | May 1998 | A |
5755696 | Caizza | May 1998 | A |
5766211 | Wood et al. | Jun 1998 | A |
5772630 | Ljungquist | Jun 1998 | A |
5772652 | Zielinski | Jun 1998 | A |
RE35841 | Frank et al. | Jul 1998 | E |
5776116 | Lopez et al. | Jul 1998 | A |
5782872 | Muller | Jul 1998 | A |
5806831 | Paradis | Sep 1998 | A |
5810792 | Fangrow, Jr. et al. | Sep 1998 | A |
5814020 | Gross | Sep 1998 | A |
D399559 | Molina | Oct 1998 | S |
5817082 | Niedospial, Jr. et al. | Oct 1998 | A |
5820621 | Yale et al. | Oct 1998 | A |
5827262 | Neftel et al. | Oct 1998 | A |
5832971 | Yale et al. | Nov 1998 | A |
5833213 | Ryan | Nov 1998 | A |
5834744 | Risman | Nov 1998 | A |
5839715 | Leinsing | Nov 1998 | A |
5853406 | Masuda et al. | Dec 1998 | A |
D405522 | Hoenig et al. | Feb 1999 | S |
5868710 | Battiato et al. | Feb 1999 | A |
5871110 | Grimard et al. | Feb 1999 | A |
5873872 | Thibault et al. | Feb 1999 | A |
5879337 | Kuracina et al. | Mar 1999 | A |
5879345 | Aneas | Mar 1999 | A |
5887633 | Yale et al. | Mar 1999 | A |
5890610 | Jansen et al. | Apr 1999 | A |
5891129 | Daubert et al. | Apr 1999 | A |
5893397 | Peterson et al. | Apr 1999 | A |
5897526 | Vaillancourt | Apr 1999 | A |
5899468 | Apps et al. | May 1999 | A |
5902280 | Powles et al. | May 1999 | A |
5902298 | Niedospial, Jr. et al. | May 1999 | A |
D410740 | Molina | Jun 1999 | S |
5911710 | Barry et al. | Jun 1999 | A |
5919182 | Avallone | Jul 1999 | A |
5921419 | Niedospial, Jr. et al. | Jul 1999 | A |
5924584 | Hellstrom et al. | Jul 1999 | A |
5925029 | Jansen et al. | Jul 1999 | A |
5935112 | Stevens et al. | Aug 1999 | A |
5941848 | Nishimoto et al. | Aug 1999 | A |
5941850 | Shah et al. | Aug 1999 | A |
5944700 | Nguyen et al. | Aug 1999 | A |
5954104 | Daubert et al. | Sep 1999 | A |
5968022 | Saito | Oct 1999 | A |
5971181 | Niedospial, Jr. et al. | Oct 1999 | A |
5971965 | Mayer | Oct 1999 | A |
5989237 | Fowles et al. | Nov 1999 | A |
6003566 | Thibault et al. | Dec 1999 | A |
6004278 | Botich et al. | Dec 1999 | A |
6019750 | Fowles et al. | Feb 2000 | A |
6022339 | Fowles et al. | Feb 2000 | A |
6036171 | Weinheimer et al. | Mar 2000 | A |
6039093 | Mrotzek et al. | Mar 2000 | A |
6039302 | Cote, Sr. et al. | Mar 2000 | A |
D422357 | Niedospial, Jr. et al. | Apr 2000 | S |
6063068 | Fowles et al. | May 2000 | A |
D427308 | Zinger | Jun 2000 | S |
D427309 | Molina | Jun 2000 | S |
6070623 | Aneas | Jun 2000 | A |
6071270 | Fowles et al. | Jun 2000 | A |
6080132 | Cole et al. | Jun 2000 | A |
D428141 | Brotspies et al. | Jul 2000 | S |
6086762 | Guala | Jul 2000 | A |
6089541 | Weinheimer et al. | Jul 2000 | A |
6090091 | Fowles et al. | Jul 2000 | A |
6090093 | Thibault et al. | Jul 2000 | A |
6092692 | Riskin | Jul 2000 | A |
D430291 | Jansen et al. | Aug 2000 | S |
6099511 | Devos | Aug 2000 | A |
6113068 | Ryan | Sep 2000 | A |
6113583 | Fowles et al. | Sep 2000 | A |
6117114 | Paradis | Sep 2000 | A |
D431864 | Jansen | Oct 2000 | S |
6139534 | Niedospial, Jr. et al. | Oct 2000 | A |
6142446 | Leinsing | Nov 2000 | A |
6146362 | Turnbull et al. | Nov 2000 | A |
6149623 | Reynolds | Nov 2000 | A |
6156025 | Niedospial, Jr. et al. | Dec 2000 | A |
6159192 | Fowles et al. | Dec 2000 | A |
6168037 | Grimard | Jan 2001 | B1 |
6171287 | Lynn et al. | Jan 2001 | B1 |
6171293 | Rowley et al. | Jan 2001 | B1 |
6173852 | Browne | Jan 2001 | B1 |
6173868 | DeJonge | Jan 2001 | B1 |
6174304 | Weston | Jan 2001 | B1 |
6179822 | Niedospial, Jr. | Jan 2001 | B1 |
6179823 | Niedospial, Jr. | Jan 2001 | B1 |
6186997 | Gabbard et al. | Feb 2001 | B1 |
6206861 | Mayer | Mar 2001 | B1 |
6221041 | Russo | Apr 2001 | B1 |
6221054 | Martin et al. | Apr 2001 | B1 |
6221065 | Davis | Apr 2001 | B1 |
6238372 | Zinger et al. | May 2001 | B1 |
6245044 | Daw et al. | Jun 2001 | B1 |
D445501 | Niedospial, Jr. | Jul 2001 | S |
D445895 | Svendsen | Jul 2001 | S |
6253804 | Safabash | Jul 2001 | B1 |
6258078 | Thilly | Jul 2001 | B1 |
6280430 | Neftel et al. | Aug 2001 | B1 |
6290688 | Lopez et al. | Sep 2001 | B1 |
6296621 | Masuda et al. | Oct 2001 | B1 |
6299131 | Ryan | Oct 2001 | B1 |
6343629 | Wessman et al. | Feb 2002 | B1 |
6348044 | Coletti et al. | Feb 2002 | B1 |
6358236 | DeFoggi et al. | Mar 2002 | B1 |
6364866 | Furr et al. | Apr 2002 | B1 |
6378576 | Thibault et al. | Apr 2002 | B2 |
6378714 | Jansen et al. | Apr 2002 | B1 |
6379340 | Zinger et al. | Apr 2002 | B1 |
D457954 | Wallace et al. | May 2002 | S |
6382442 | Thibault et al. | May 2002 | B1 |
6386397 | Brotspies et al. | May 2002 | B2 |
6408897 | Laurent et al. | Jun 2002 | B1 |
6409708 | Wessman | Jun 2002 | B1 |
6440107 | Trombley, III et al. | Aug 2002 | B1 |
6453949 | Chau | Sep 2002 | B1 |
6453956 | Safabash | Sep 2002 | B2 |
6474375 | Spero et al. | Nov 2002 | B2 |
6478788 | Aneas | Nov 2002 | B1 |
D468015 | Horppu | Dec 2002 | S |
6499617 | Niedospial, Jr. et al. | Dec 2002 | B1 |
6503240 | Niedospial, Jr. et al. | Jan 2003 | B1 |
6503244 | Hayman | Jan 2003 | B2 |
6520932 | Taylor | Feb 2003 | B2 |
6524278 | Campbell et al. | Feb 2003 | B1 |
6524295 | Daubert et al. | Feb 2003 | B2 |
D472316 | Douglas et al. | Mar 2003 | S |
6530903 | Wang et al. | Mar 2003 | B2 |
6537263 | Aneas | Mar 2003 | B1 |
D472630 | Douglas et al. | Apr 2003 | S |
6544246 | Niedospial, Jr. | Apr 2003 | B1 |
6551299 | Miyoshi et al. | Apr 2003 | B2 |
6558365 | Zinger et al. | May 2003 | B2 |
6571837 | Jansen et al. | Jun 2003 | B2 |
6572591 | Mayer | Jun 2003 | B2 |
6575955 | Azzolini | Jun 2003 | B2 |
6581593 | Rubin et al. | Jun 2003 | B1 |
6582415 | Fowles et al. | Jun 2003 | B1 |
D476731 | Cise et al. | Jul 2003 | S |
6591876 | Safabash | Jul 2003 | B2 |
6599273 | Lopez | Jul 2003 | B1 |
6601721 | Jansen et al. | Aug 2003 | B2 |
6626309 | Jansen et al. | Sep 2003 | B1 |
6632201 | Mathias et al. | Oct 2003 | B1 |
6638244 | Reynolds | Oct 2003 | B1 |
D482121 | Harding et al. | Nov 2003 | S |
D482447 | Harding et al. | Nov 2003 | S |
6651956 | Miller | Nov 2003 | B2 |
6652509 | Helgren et al. | Nov 2003 | B1 |
D483487 | Harding et al. | Dec 2003 | S |
D483869 | Tran et al. | Dec 2003 | S |
6656433 | Sasso | Dec 2003 | B2 |
6666852 | Niedospial, Jr. | Dec 2003 | B2 |
6681810 | Weston | Jan 2004 | B2 |
6681946 | Jansen et al. | Jan 2004 | B1 |
6682509 | Lopez | Jan 2004 | B2 |
6692478 | Paradis | Feb 2004 | B1 |
6692829 | Stubler et al. | Feb 2004 | B2 |
6699229 | Zinger et al. | Mar 2004 | B2 |
6706022 | Leinsing et al. | Mar 2004 | B1 |
6706031 | Manera | Mar 2004 | B2 |
6715520 | Andreasson et al. | Apr 2004 | B2 |
6729370 | Norton et al. | May 2004 | B2 |
6736798 | Ohkubo et al. | May 2004 | B2 |
6745998 | Doyle | Jun 2004 | B2 |
6746438 | Amissolle | Jun 2004 | B1 |
6752180 | Delay | Jun 2004 | B2 |
D495416 | Dimeo et al. | Aug 2004 | S |
D496457 | Prais et al. | Sep 2004 | S |
6802490 | Leinsing et al. | Oct 2004 | B2 |
6832994 | Niedospial, Jr. et al. | Dec 2004 | B2 |
6852103 | Fowles et al. | Feb 2005 | B2 |
6875203 | Fowles et al. | Apr 2005 | B1 |
6875205 | Leinsing | Apr 2005 | B2 |
6878131 | Novacek et al. | Apr 2005 | B2 |
6884253 | McFarlane | Apr 2005 | B1 |
6890328 | Fowles et al. | May 2005 | B2 |
D506256 | Miyoshi et al. | Jun 2005 | S |
6901975 | Aramata et al. | Jun 2005 | B2 |
6945417 | Jansen et al. | Sep 2005 | B2 |
6948522 | Newbrough et al. | Sep 2005 | B2 |
6949086 | Ferguson et al. | Sep 2005 | B2 |
6951613 | Reif et al. | Oct 2005 | B2 |
6957745 | Thibault et al. | Oct 2005 | B2 |
6960164 | O'Heeron | Nov 2005 | B2 |
6972002 | Thorne | Dec 2005 | B2 |
6979318 | McDonald et al. | Dec 2005 | B1 |
RE38996 | Crawford et al. | Feb 2006 | E |
6994315 | Ryan et al. | Feb 2006 | B2 |
6997916 | Simas, Jr. et al. | Feb 2006 | B2 |
6997917 | Niedospial, Jr. et al. | Feb 2006 | B2 |
7024968 | Raudabough et al. | Apr 2006 | B2 |
7070589 | Lolachi et al. | Jul 2006 | B2 |
7074216 | Fowles et al. | Jul 2006 | B2 |
7083600 | Meloul | Aug 2006 | B2 |
7086431 | D'Antonio et al. | Aug 2006 | B2 |
7097637 | Triplett et al. | Aug 2006 | B2 |
7100890 | Cote, Sr. et al. | Sep 2006 | B2 |
7140401 | Wilcox et al. | Nov 2006 | B2 |
7150735 | Hickle | Dec 2006 | B2 |
7192423 | Wong | Mar 2007 | B2 |
7195623 | Burroughs et al. | Mar 2007 | B2 |
7241285 | Dikeman | Jul 2007 | B1 |
7294122 | Kubo et al. | Nov 2007 | B2 |
7306199 | Leinsing et al. | Dec 2007 | B2 |
D561348 | Zinger et al. | Feb 2008 | S |
7326188 | Russell et al. | Feb 2008 | B1 |
7326194 | Zinger et al. | Feb 2008 | B2 |
7350764 | Raybuck | Apr 2008 | B2 |
7354422 | Riesenberger et al. | Apr 2008 | B2 |
7354427 | Fangrow | Apr 2008 | B2 |
7425209 | Fowles et al. | Sep 2008 | B2 |
7435246 | Zihlmann | Oct 2008 | B2 |
D580558 | Shigesada et al. | Nov 2008 | S |
7452348 | Hasegawa | Nov 2008 | B2 |
7470257 | Norton et al. | Dec 2008 | B2 |
7470265 | Brugger et al. | Dec 2008 | B2 |
7472932 | Weber et al. | Jan 2009 | B2 |
7488297 | Flaherty | Feb 2009 | B2 |
7491197 | Jansen et al. | Feb 2009 | B2 |
7497848 | Leinsing et al. | Mar 2009 | B2 |
7523967 | Steppe | Apr 2009 | B2 |
7530546 | Ryan et al. | May 2009 | B2 |
D595420 | Suzuki et al. | Jun 2009 | S |
D595421 | Suzuki et al. | Jun 2009 | S |
7540863 | Haindl | Jun 2009 | B2 |
7540865 | Griffin et al. | Jun 2009 | B2 |
7544191 | Peluso et al. | Jun 2009 | B2 |
D595862 | Suzuki et al. | Jul 2009 | S |
D595863 | Suzuki et al. | Jul 2009 | S |
7611487 | Woehr et al. | Nov 2009 | B2 |
7611502 | Daly | Nov 2009 | B2 |
7615041 | Sullivan et al. | Nov 2009 | B2 |
7628779 | Aneas | Dec 2009 | B2 |
7632261 | Zinger et al. | Dec 2009 | B2 |
D608900 | Giraud et al. | Jan 2010 | S |
7654995 | Warren et al. | Feb 2010 | B2 |
7670326 | Shemesh | Mar 2010 | B2 |
7695445 | Yuki | Apr 2010 | B2 |
7704229 | Moberg et al. | Apr 2010 | B2 |
D616090 | Kawamura | May 2010 | S |
7713247 | Lopez | May 2010 | B2 |
7717886 | Lopez | May 2010 | B2 |
7722090 | Burton et al. | May 2010 | B2 |
D616984 | Gilboa | Jun 2010 | S |
7731678 | Tennican et al. | Jun 2010 | B2 |
7743799 | Mosler et al. | Jun 2010 | B2 |
7744581 | Wallen et al. | Jun 2010 | B2 |
7757901 | Welp | Jul 2010 | B2 |
7758082 | Weigel et al. | Jul 2010 | B2 |
7758560 | Connell et al. | Jul 2010 | B2 |
7762524 | Cawthon et al. | Jul 2010 | B2 |
7766304 | Phillips | Aug 2010 | B2 |
7771383 | Truitt | Aug 2010 | B2 |
D624641 | Boclet | Sep 2010 | S |
7799009 | Niedospial, Jr. et al. | Sep 2010 | B2 |
7803140 | Fangrow, Jr. | Sep 2010 | B2 |
D627216 | Fulginiti | Nov 2010 | S |
D630732 | Lev et al. | Jan 2011 | S |
7862537 | Zinger et al. | Jan 2011 | B2 |
7867215 | Akerlund et al. | Jan 2011 | B2 |
7879018 | Zinger et al. | Feb 2011 | B2 |
7883499 | Fangrow | Feb 2011 | B2 |
7895216 | Longshaw et al. | Feb 2011 | B2 |
D634007 | Zinger et al. | Mar 2011 | S |
7900659 | Whitley et al. | Mar 2011 | B2 |
D637713 | Nord et al. | May 2011 | S |
7963954 | Kavazov | Jun 2011 | B2 |
D641080 | Zinger et al. | Jul 2011 | S |
7985216 | Daily et al. | Jul 2011 | B2 |
D644104 | Maeda et al. | Aug 2011 | S |
3007461 | Huo et al. | Aug 2011 | A1 |
7993328 | Whitley | Aug 2011 | B2 |
3021325 | Zinger et al. | Sep 2011 | A1 |
8012132 | Lum et al. | Sep 2011 | B2 |
8016809 | Zinger et al. | Sep 2011 | B2 |
8025653 | Capitaine et al. | Sep 2011 | B2 |
8025683 | Morrison | Sep 2011 | B2 |
8029472 | Leinsing et al. | Oct 2011 | B2 |
8038123 | Ruschke et al. | Oct 2011 | B2 |
8066688 | Zinger et al. | Nov 2011 | B2 |
8070739 | Zinger et al. | Dec 2011 | B2 |
8075550 | Nord et al. | Dec 2011 | B2 |
8096525 | Ryan | Jan 2012 | B2 |
8105314 | Fangrow, Jr. | Jan 2012 | B2 |
D654166 | Lair | Feb 2012 | S |
D655017 | Mosler et al. | Feb 2012 | S |
8122923 | Kraus et al. | Feb 2012 | B2 |
8123736 | Kraushaar et al. | Feb 2012 | B2 |
D655071 | Davila | Mar 2012 | S |
D657461 | Schembre et al. | Apr 2012 | S |
8152779 | Cabiri | Apr 2012 | B2 |
8157784 | Rogers | Apr 2012 | B2 |
8167863 | Yow | May 2012 | B2 |
8172824 | Pfeifer et al. | May 2012 | B2 |
8177768 | Leinsing | May 2012 | B2 |
8182452 | Mansour et al. | May 2012 | B2 |
8187248 | Zihlmann | May 2012 | B2 |
8196614 | Kriheli | Jun 2012 | B2 |
8197459 | Jansen et al. | Jun 2012 | B2 |
8211069 | Fangrow, Jr. | Jul 2012 | B2 |
8225959 | Lambrecht | Jul 2012 | B2 |
8241268 | Whitley | Aug 2012 | B2 |
8262628 | Fangrow, Jr. | Sep 2012 | B2 |
8262641 | Vedrine et al. | Sep 2012 | B2 |
8267127 | Kriheli | Sep 2012 | B2 |
D669980 | Lev et al. | Oct 2012 | S |
8287513 | Ellstrom et al. | Oct 2012 | B2 |
8328784 | Jensen et al. | Dec 2012 | B2 |
D673673 | Wang | Jan 2013 | S |
D674084 | Linnenschmidt | Jan 2013 | S |
D674088 | Lev et al. | Jan 2013 | S |
8348898 | Cabiri | Jan 2013 | B2 |
D681230 | Mosier et al. | Apr 2013 | S |
8454573 | Wyatt et al. | Jun 2013 | B2 |
8469939 | Fangrow, Jr. | Jun 2013 | B2 |
8475404 | Foshee et al. | Jul 2013 | B2 |
8480645 | Choudhury et al. | Jul 2013 | B1 |
8480646 | Nord et al. | Jul 2013 | B2 |
8506548 | Okiyama | Aug 2013 | B2 |
8511352 | Kraus et al. | Aug 2013 | B2 |
8512309 | Shemesh et al. | Aug 2013 | B2 |
D690009 | Schembre et al. | Sep 2013 | S |
D690418 | Rosenquist | Sep 2013 | S |
8523837 | Wiggins et al. | Sep 2013 | B2 |
8545476 | Ariagno et al. | Oct 2013 | B2 |
8551067 | Zinger et al. | Oct 2013 | B2 |
8556879 | Okiyama | Oct 2013 | B2 |
8562582 | Tuckwell et al. | Oct 2013 | B2 |
8608723 | Lev et al. | Dec 2013 | B2 |
8628508 | Weitzel et al. | Jan 2014 | B2 |
8636689 | Halili, Jr. et al. | Jan 2014 | B2 |
8684994 | Lev et al. | Apr 2014 | B2 |
D714935 | Nishioka et al. | Oct 2014 | S |
D717406 | Stanley et al. | Nov 2014 | S |
D717948 | Strong et al. | Nov 2014 | S |
D719650 | Arinobe et al. | Dec 2014 | S |
D720067 | Rosenquist | Dec 2014 | S |
D720451 | Denenburg et al. | Dec 2014 | S |
D720452 | Jordan | Dec 2014 | S |
8900212 | Kubo | Dec 2014 | B2 |
8905994 | Lev | Dec 2014 | B1 |
8915882 | Cabiri | Dec 2014 | B2 |
D720850 | Hsia et al. | Jan 2015 | S |
D732660 | Ohashi | Jun 2015 | S |
D732664 | Woehr et al. | Jun 2015 | S |
D733291 | Wang | Jun 2015 | S |
D733292 | Rogers | Jun 2015 | S |
D733293 | Rogers | Jun 2015 | S |
9072827 | Cabiri | Jul 2015 | B2 |
D738494 | Kashmirian | Sep 2015 | S |
D741457 | Guest | Oct 2015 | S |
9149575 | Cabiri | Oct 2015 | B2 |
D750235 | Maurice | Feb 2016 | S |
9254242 | Mueller et al. | Feb 2016 | B2 |
D757933 | Lev et al. | May 2016 | S |
9339438 | Lev et al. | May 2016 | B2 |
9393365 | Cabiri | Jul 2016 | B2 |
9414991 | Sanders et al. | Aug 2016 | B2 |
9486391 | Shemesh | Nov 2016 | B2 |
9492610 | Cabiri | Nov 2016 | B2 |
9511190 | Cabiri | Dec 2016 | B2 |
9522234 | Cabiri | Dec 2016 | B2 |
D794183 | Lev et al. | Aug 2017 | S |
9763855 | Fangrow | Sep 2017 | B2 |
9801786 | Lev et al. | Oct 2017 | B2 |
10206854 | Wu et al. | Feb 2019 | B2 |
10376654 | Sanders et al. | Aug 2019 | B2 |
20010000347 | Hellstrom et al. | Apr 2001 | A1 |
20010025671 | Safabash | Oct 2001 | A1 |
20010029360 | Miyoshi et al. | Oct 2001 | A1 |
20010051793 | Weston | Dec 2001 | A1 |
20020017328 | Loo | Feb 2002 | A1 |
20020055711 | Lavi et al. | May 2002 | A1 |
20020065488 | Suzuki et al. | May 2002 | A1 |
20020066715 | Niedospial | Jun 2002 | A1 |
20020087118 | Reynolds et al. | Jul 2002 | A1 |
20020087141 | Zinger et al. | Jul 2002 | A1 |
20020087144 | Zinger et al. | Jul 2002 | A1 |
20020104584 | Spero et al. | Aug 2002 | A1 |
20020115980 | Niedospial et al. | Aug 2002 | A1 |
20020121496 | Thiebault et al. | Sep 2002 | A1 |
20020123736 | Fowles et al. | Sep 2002 | A1 |
20020127150 | Sasso | Sep 2002 | A1 |
20020128628 | Fathallah | Sep 2002 | A1 |
20020138045 | Moen | Sep 2002 | A1 |
20020173752 | Polzin | Nov 2002 | A1 |
20020193777 | Aneas | Dec 2002 | A1 |
20030028156 | Juliar | Feb 2003 | A1 |
20030036725 | Lavi et al. | Feb 2003 | A1 |
20030068354 | Reif et al. | Apr 2003 | A1 |
20030069550 | Sharp | Apr 2003 | A1 |
20030073971 | Saker | Apr 2003 | A1 |
20030100866 | Reynolds | May 2003 | A1 |
20030109846 | Zinger et al. | Jun 2003 | A1 |
20030120209 | Jensen et al. | Jun 2003 | A1 |
20030135159 | Daily et al. | Jul 2003 | A1 |
20030153895 | Leinsing | Aug 2003 | A1 |
20030187420 | Akerlund et al. | Oct 2003 | A1 |
20030191445 | Wallen et al. | Oct 2003 | A1 |
20030195479 | Kuracina et al. | Oct 2003 | A1 |
20030199827 | Thorne | Oct 2003 | A1 |
20030199846 | Fowles et al. | Oct 2003 | A1 |
20030199847 | Akerlund et al. | Oct 2003 | A1 |
20030205843 | Adams | Nov 2003 | A1 |
20030236543 | Brenneman et al. | Dec 2003 | A1 |
20040010207 | Flaherty et al. | Jan 2004 | A1 |
20040024354 | Reynolds | Feb 2004 | A1 |
20040039365 | Aramata et al. | Feb 2004 | A1 |
20040044327 | Hasegawa | Mar 2004 | A1 |
20040073189 | Wyatt et al. | Apr 2004 | A1 |
20040143218 | Das | Jul 2004 | A1 |
20040143226 | Marsden | Jul 2004 | A1 |
20040153047 | Blank et al. | Aug 2004 | A1 |
20040158172 | Hancock | Aug 2004 | A1 |
20040162540 | Walenciak et al. | Aug 2004 | A1 |
20040167472 | Howell et al. | Aug 2004 | A1 |
20040181192 | Cuppy | Sep 2004 | A1 |
20040186424 | Hjertman | Sep 2004 | A1 |
20040199139 | Fowles et al. | Oct 2004 | A1 |
20040204699 | Hanly et al. | Oct 2004 | A1 |
20040217315 | Doyle | Nov 2004 | A1 |
20040225274 | Jansen et al. | Nov 2004 | A1 |
20040236305 | Jansen et al. | Nov 2004 | A1 |
20040249341 | Newbrough et al. | Dec 2004 | A1 |
20040255952 | Carlsen et al. | Dec 2004 | A1 |
20050015070 | Delnevo et al. | Jan 2005 | A1 |
20050016626 | Wilcox et al. | Jan 2005 | A1 |
20050049553 | Triplett et al. | Mar 2005 | A1 |
20050055008 | Paradis et al. | Mar 2005 | A1 |
20050082828 | Wicks et al. | Apr 2005 | A1 |
20050124964 | Niedospial et al. | Jun 2005 | A1 |
20050137523 | Wyatt et al. | Jun 2005 | A1 |
20050137566 | Fowles et al. | Jun 2005 | A1 |
20050148994 | Leinsing | Jul 2005 | A1 |
20050159706 | Wilkinson et al. | Jul 2005 | A1 |
20050159724 | Enerson | Jul 2005 | A1 |
20050182383 | Wallen | Aug 2005 | A1 |
20050209554 | Landau | Sep 2005 | A1 |
20050261637 | Miller | Nov 2005 | A1 |
20050277896 | Messerli et al. | Dec 2005 | A1 |
20060030832 | Niedospial et al. | Feb 2006 | A1 |
20060079834 | Tennican et al. | Apr 2006 | A1 |
20060089594 | Landau | Apr 2006 | A1 |
20060089603 | Truitt et al. | Apr 2006 | A1 |
20060095015 | Hobbs et al. | May 2006 | A1 |
20060106360 | Wong | May 2006 | A1 |
20060135948 | Varma | Jun 2006 | A1 |
20060155257 | Reynolds | Jul 2006 | A1 |
20060161192 | Young | Jul 2006 | A1 |
20060173410 | Moberg et al. | Aug 2006 | A1 |
20060178646 | Harris et al. | Aug 2006 | A1 |
20060195029 | Shults et al. | Aug 2006 | A1 |
20060212004 | Atil | Sep 2006 | A1 |
20060253084 | Nordgren | Nov 2006 | A1 |
20060259004 | Connell et al. | Nov 2006 | A1 |
20070016381 | Kamath et al. | Jan 2007 | A1 |
20070024995 | Hayashi | Feb 2007 | A1 |
20070060904 | Vedrine et al. | Mar 2007 | A1 |
20070078428 | Reynolds et al. | Apr 2007 | A1 |
20070079894 | Kraus et al. | Apr 2007 | A1 |
20070083164 | Barrelle et al. | Apr 2007 | A1 |
20070088252 | Pestotnik et al. | Apr 2007 | A1 |
20070088293 | Fangrow | Apr 2007 | A1 |
20070088313 | Zinger et al. | Apr 2007 | A1 |
20070106218 | Yodfat et al. | May 2007 | A1 |
20070106244 | Mosler et al. | May 2007 | A1 |
20070112324 | Harnedi-Sangsari | May 2007 | A1 |
20070156112 | Walsh | Jul 2007 | A1 |
20070167904 | Zinger et al. | Jul 2007 | A1 |
20070167912 | Causey et al. | Jul 2007 | A1 |
20070191760 | Iguchi et al. | Aug 2007 | A1 |
20070191764 | Zihlmann | Aug 2007 | A1 |
20070191767 | Hennessy et al. | Aug 2007 | A1 |
20070203451 | Murakami et al. | Aug 2007 | A1 |
20070219483 | Kitani et al. | Sep 2007 | A1 |
20070244447 | Capitaine et al. | Oct 2007 | A1 |
20070244461 | Fangrow | Oct 2007 | A1 |
20070244462 | Fangrow | Oct 2007 | A1 |
20070244463 | Warren et al. | Oct 2007 | A1 |
20070249995 | Van Manen | Oct 2007 | A1 |
20070255202 | Kitani et al. | Nov 2007 | A1 |
20070265574 | Tennican et al. | Nov 2007 | A1 |
20070265581 | Funamura et al. | Nov 2007 | A1 |
20070270778 | Zinger et al. | Nov 2007 | A9 |
20070287953 | Ziv et al. | Dec 2007 | A1 |
20070299404 | Katoh et al. | Dec 2007 | A1 |
20080009789 | Zinger et al. | Jan 2008 | A1 |
20080009822 | Enerson | Jan 2008 | A1 |
20080015496 | Hamedi-Sangsari | Jan 2008 | A1 |
20080132851 | Shaw et al. | Jun 2008 | A1 |
20080135051 | Lee | Jun 2008 | A1 |
20080172024 | Yow | Jul 2008 | A1 |
20080188799 | Mueller-Beckhaus et al. | Aug 2008 | A1 |
20080195049 | Thalmann et al. | Aug 2008 | A1 |
20080208138 | Lim et al. | Aug 2008 | A1 |
20080215015 | Cindrich et al. | Sep 2008 | A1 |
20080249473 | Ruth et al. | Oct 2008 | A1 |
20080249479 | Zinger et al. | Oct 2008 | A1 |
20080249498 | Fangrow | Oct 2008 | A1 |
20080262465 | Zinger et al. | Oct 2008 | A1 |
20080269687 | Chong et al. | Oct 2008 | A1 |
20080275407 | Scheurer | Nov 2008 | A1 |
20080287905 | Hiejima et al. | Nov 2008 | A1 |
20080294100 | de Costa et al. | Nov 2008 | A1 |
20080306439 | Nelson et al. | Dec 2008 | A1 |
20080312634 | Helmerson et al. | Dec 2008 | A1 |
20090012492 | Zihlmann | Jan 2009 | A1 |
20090043253 | Podaima | Feb 2009 | A1 |
20090054834 | Zinger et al. | Feb 2009 | A1 |
20090054852 | Takano et al. | Feb 2009 | A1 |
20090062767 | Van Antwerp et al. | Mar 2009 | A1 |
20090076360 | Brister et al. | Mar 2009 | A1 |
20090082750 | Denenburg et al. | Mar 2009 | A1 |
20090139724 | Gray et al. | Jun 2009 | A1 |
20090143758 | Okiyama | Jun 2009 | A1 |
20090177177 | Zinger et al. | Jul 2009 | A1 |
20090177178 | Pedersen | Jul 2009 | A1 |
20090187140 | Racz | Jul 2009 | A1 |
20090216103 | Brister et al. | Aug 2009 | A1 |
20090216212 | Fangrow, Jr. | Aug 2009 | A1 |
20090267011 | Hatton | Oct 2009 | A1 |
20090299325 | Vedrine et al. | Dec 2009 | A1 |
20090318946 | Tamesada | Dec 2009 | A1 |
20090326506 | Hasegawa et al. | Dec 2009 | A1 |
20100010443 | Morgan et al. | Jan 2010 | A1 |
20100016811 | Smith | Jan 2010 | A1 |
20100022985 | Sullivan et al. | Jan 2010 | A1 |
20100030181 | Helle et al. | Feb 2010 | A1 |
20100036319 | Drake et al. | Feb 2010 | A1 |
20100076397 | Reed et al. | Mar 2010 | A1 |
20100087786 | Zinger et al. | Apr 2010 | A1 |
20100137827 | Warren et al. | Jun 2010 | A1 |
20100137831 | Tsals | Jun 2010 | A1 |
20100152658 | Hanson et al. | Jun 2010 | A1 |
20100160889 | Smith et al. | Jun 2010 | A1 |
20100162548 | Leidig | Jul 2010 | A1 |
20100168664 | Zinger et al. | Jul 2010 | A1 |
20100168712 | Tuckwell et al. | Jul 2010 | A1 |
20100179506 | Shemesh et al. | Jul 2010 | A1 |
20100198148 | Zinger et al. | Aug 2010 | A1 |
20100204670 | Kraushaar et al. | Aug 2010 | A1 |
20100228220 | Zinger et al. | Sep 2010 | A1 |
20100241088 | Ranalletta et al. | Sep 2010 | A1 |
20100274184 | Chun | Oct 2010 | A1 |
20100274202 | Hyde et al. | Oct 2010 | A1 |
20100286661 | Raday et al. | Nov 2010 | A1 |
20100312220 | Kalitzki | Dec 2010 | A1 |
20110004143 | Beiriger et al. | Jan 2011 | A1 |
20110004184 | Proksch et al. | Jan 2011 | A1 |
20110044850 | Solomon et al. | Feb 2011 | A1 |
20110054440 | Lewis | Mar 2011 | A1 |
20110087164 | Mosier et al. | Apr 2011 | A1 |
20110125056 | Merchant | May 2011 | A1 |
20110144584 | Wozencroft | Jun 2011 | A1 |
20110160655 | Hanson et al. | Jun 2011 | A1 |
20110160701 | Wyatt et al. | Jun 2011 | A1 |
20110172636 | Aasmul | Jul 2011 | A1 |
20110175347 | Okiyama | Jul 2011 | A1 |
20110218511 | Yokoyama | Sep 2011 | A1 |
20110224640 | Kuhn et al. | Sep 2011 | A1 |
20110230856 | Kyle et al. | Sep 2011 | A1 |
20110264037 | Foshee et al. | Oct 2011 | A1 |
20110264069 | Bochenko | Oct 2011 | A1 |
20110276007 | Denenburg | Nov 2011 | A1 |
20110319827 | Leinsing et al. | Dec 2011 | A1 |
20120022344 | Kube | Jan 2012 | A1 |
20120022469 | Alpert | Jan 2012 | A1 |
20120053555 | Ariagno et al. | Mar 2012 | A1 |
20120059332 | Woehr et al. | Mar 2012 | A1 |
20120059346 | Sheppard et al. | Mar 2012 | A1 |
20120067429 | Mosler et al. | Mar 2012 | A1 |
20120071819 | Bruggemann et al. | Mar 2012 | A1 |
20120078214 | Finke et al. | Mar 2012 | A1 |
20120123382 | Kubo | May 2012 | A1 |
20120184938 | Lev et al. | Jul 2012 | A1 |
20120215182 | Mansour et al. | Aug 2012 | A1 |
20120220977 | Yow | Aug 2012 | A1 |
20120220978 | Lev et al. | Aug 2012 | A1 |
20120265163 | Cheng et al. | Oct 2012 | A1 |
20120271229 | Lev et al. | Oct 2012 | A1 |
20120296307 | Holt et al. | Nov 2012 | A1 |
20120310203 | Khaled et al. | Dec 2012 | A1 |
20120323172 | Lev | Dec 2012 | A1 |
20120323187 | Iwase et al. | Dec 2012 | A1 |
20120323210 | Lev et al. | Dec 2012 | A1 |
20130046269 | Lev et al. | Feb 2013 | A1 |
20130053814 | Mueller-Beckhaus et al. | Feb 2013 | A1 |
20130096493 | Kubo et al. | Apr 2013 | A1 |
20130110049 | Cronenberg et al. | May 2013 | A1 |
20130144248 | Putter et al. | Jun 2013 | A1 |
20130199669 | Moy et al. | Aug 2013 | A1 |
20130226100 | Lev | Aug 2013 | A1 |
20130231630 | Kraus et al. | Sep 2013 | A1 |
20130237904 | Deneburg et al. | Sep 2013 | A1 |
20130253448 | Baron et al. | Sep 2013 | A1 |
20130289530 | Wyatt et al. | Oct 2013 | A1 |
20140020793 | Denenburg et al. | Jan 2014 | A1 |
20140096862 | Aneas | Apr 2014 | A1 |
20140150911 | Planner et al. | Jun 2014 | A1 |
20140194854 | Tsals | Jul 2014 | A1 |
20140221940 | Clauson et al. | Aug 2014 | A1 |
20140277052 | Haselby et al. | Sep 2014 | A1 |
20140352845 | Lev et al. | Dec 2014 | A1 |
20150082746 | Ivosevic et al. | Mar 2015 | A1 |
20150088078 | Lev et al. | Mar 2015 | A1 |
20150112297 | Lev et al. | Apr 2015 | A1 |
20150290390 | Ring et al. | Oct 2015 | A1 |
20150297839 | Sanders et al. | Oct 2015 | A1 |
20150305770 | Fill et al. | Oct 2015 | A1 |
20160088995 | Ueda et al. | Mar 2016 | A1 |
20160166824 | Lev et al. | Jun 2016 | A1 |
20160199569 | Yevmenenko et al. | Jul 2016 | A1 |
20160228644 | Cabiri | Aug 2016 | A1 |
20160287475 | Yevmenenko et al. | Oct 2016 | A1 |
20160367439 | Davis et al. | Dec 2016 | A1 |
20190133885 | Wu et al. | May 2019 | A1 |
Number | Date | Country |
---|---|---|
2946559 | Oct 2015 | CA |
1636605 | Jul 2005 | CN |
1747683 | Mar 2006 | CN |
1863566 | Nov 2006 | CN |
1950049 | Apr 2007 | CN |
101001661 | Jul 2007 | CN |
101687083 | Mar 2010 | CN |
1064693 | Sep 1959 | DE |
1913926 | Sep 1970 | DE |
4122476 | Jan 1993 | DE |
0637443 | Feb 1995 | DE |
1408498 | May 1995 | DE |
19504413 | Aug 1996 | DE |
202004012714 | Nov 2004 | DE |
102007046951 | Feb 2009 | DE |
202009011019 | Dec 2010 | DE |
000627237-0001 | Jan 2007 | EM |
001680703-0002 | Mar 2010 | EM |
0192661 | Sep 1986 | EP |
0195018 | Sep 1986 | EP |
0258913 | Mar 1988 | EP |
0416454 | Mar 1991 | EP |
0282545 | Feb 1992 | EP |
0518397 | Dec 1992 | EP |
0521460 | Jan 1993 | EP |
582038 | Feb 1994 | EP |
0598918 | Jun 1994 | EP |
0737467 | Oct 1996 | EP |
761562 | Mar 1997 | EP |
765652 | Apr 1997 | EP |
765853 | Apr 1997 | EP |
0806597 | Nov 1997 | EP |
0814866 | Jan 1998 | EP |
829248 | Mar 1998 | EP |
0856331 | Aug 1998 | EP |
882441 | Dec 1998 | EP |
0887085 | Dec 1998 | EP |
0887885 | Dec 1998 | EP |
897708 | Feb 1999 | EP |
0898951 | Mar 1999 | EP |
960616 | Dec 1999 | EP |
1008337 | Jun 2000 | EP |
1029526 | Aug 2000 | EP |
1034809 | Sep 2000 | EP |
1051988 | Nov 2000 | EP |
1323403 | Jul 2003 | EP |
1329210 | Jul 2003 | EP |
1396250 | Mar 2004 | EP |
1454609 | Sep 2004 | EP |
1454650 | Sep 2004 | EP |
1498097 | Jan 2005 | EP |
1872824 | Jan 2008 | EP |
1911432 | Apr 2008 | EP |
1919432 | May 2008 | EP |
1930038 | Jun 2008 | EP |
2090278 | Aug 2009 | EP |
2351548 | Aug 2011 | EP |
2351549 | Aug 2011 | EP |
2462913 | Jun 2012 | EP |
2512399 | Oct 2012 | EP |
2029242 | Oct 1970 | FR |
2856660 | Dec 2004 | FR |
2869795 | Nov 2005 | FR |
2931363 | Nov 2009 | FR |
1444210 | Jul 1976 | GB |
186290 | Jan 2008 | IL |
03-062426 | Sep 1991 | JP |
06-050656 | Jul 1994 | JP |
H08-000710 | Jan 1996 | JP |
09-104460 | Apr 1997 | JP |
09-104461 | Apr 1997 | JP |
10-118158 | May 1998 | JP |
110-504736 | May 1998 | JP |
H11503627 | Mar 1999 | JP |
11-319031 | Nov 1999 | JP |
2000-508934 | Jul 2000 | JP |
2000-237278 | Sep 2000 | JP |
2000262497 | Sep 2000 | JP |
2001-505083 | Apr 2001 | JP |
2002-035140 | Feb 2002 | JP |
2002-516160 | Jun 2002 | JP |
2002-355318 | Dec 2002 | JP |
2003-033441 | Feb 2003 | JP |
2003-102807 | Apr 2003 | JP |
2004-501721 | Jan 2004 | JP |
2004-097253 | Apr 2004 | JP |
2004-522541 | Jul 2004 | JP |
2005-270629 | Oct 2005 | JP |
200661421 | Mar 2006 | JP |
2008-220961 | Sep 2008 | JP |
4329954 | Sep 2009 | JP |
0426403 | Mar 2010 | JP |
2010063622 | Mar 2010 | JP |
2010-179128 | Aug 2010 | JP |
2012-205769 | Oct 2012 | JP |
2014000220 | Jan 2014 | JP |
8601712 | Mar 1986 | WO |
8605683 | Oct 1986 | WO |
9003536 | Apr 1990 | WO |
9403373 | Feb 1994 | WO |
9507066 | Mar 1995 | WO |
9513785 | May 1995 | WO |
9600053 | Jan 1996 | WO |
9609083 | Mar 1996 | WO |
9629113 | Sep 1996 | WO |
9736636 | Oct 1997 | WO |
9832411 | Jul 1998 | WO |
9837854 | Sep 1998 | WO |
9961093 | Dec 1999 | WO |
0128490 | Apr 2001 | WO |
0130425 | May 2001 | WO |
0132524 | May 2001 | WO |
0160311 | Aug 2001 | WO |
0191693 | Dec 2001 | WO |
0202165 | Jan 2002 | WO |
200209797 | Feb 2002 | WO |
0236191 | May 2002 | WO |
02089900 | Nov 2002 | WO |
03051423 | Jun 2003 | WO |
03070147 | Aug 2003 | WO |
03079956 | Oct 2003 | WO |
2004041148 | May 2004 | WO |
2004096113 | Nov 2004 | WO |
2005002492 | Jan 2005 | WO |
2005018703 | Mar 2005 | WO |
2005041846 | May 2005 | WO |
2005105014 | Nov 2005 | WO |
2005105014 | Nov 2005 | WO |
2006099441 | Sep 2006 | WO |
2007015233 | Feb 2007 | WO |
2007017868 | Feb 2007 | WO |
2007052252 | May 2007 | WO |
2007105221 | Sep 2007 | WO |
2007101772 | Sep 2007 | WO |
2008076459 | Jun 2008 | WO |
2008081424 | Jul 2008 | WO |
02066100 | Aug 2008 | WO |
2008126090 | Oct 2008 | WO |
2009026443 | Feb 2009 | WO |
2009029010 | Mar 2009 | WO |
2009038860 | Mar 2009 | WO |
2009040804 | Apr 2009 | WO |
2009087572 | Jul 2009 | WO |
2009093249 | Jul 2009 | WO |
2009112489 | Sep 2009 | WO |
2009146088 | Dec 2009 | WO |
2010061743 | Jun 2010 | WO |
2010078227 | Jul 2010 | WO |
2010117580 | Oct 2010 | WO |
2011004360 | Jan 2011 | WO |
0189607 | Jan 2011 | WO |
2011039747 | Apr 2011 | WO |
2011058545 | May 2011 | WO |
2011058548 | May 2011 | WO |
2011058548 | May 2011 | WO |
2011077434 | Jun 2011 | WO |
2011090955 | Jul 2011 | WO |
2011104711 | Sep 2011 | WO |
2011156373 | Dec 2011 | WO |
2012004790 | Jan 2012 | WO |
2012004784 | Jan 2012 | WO |
2012063230 | May 2012 | WO |
2012063230 | May 2012 | WO |
2012143921 | Oct 2012 | WO |
2012150587 | Nov 2012 | WO |
2013127813 | Sep 2013 | WO |
2013134246 | Sep 2013 | WO |
2013148435 | Oct 2013 | WO |
2013156944 | Oct 2013 | WO |
2013156994 | Oct 2013 | WO |
2014033706 | Mar 2014 | WO |
2014033710 | Mar 2014 | WO |
2014099395 | Jun 2014 | WO |
2014170888 | Oct 2014 | WO |
2014174278 | Oct 2014 | WO |
2014174278 | Oct 2014 | WO |
2016023590 | Feb 2016 | WO |
2016023590 | Feb 2016 | WO |
Entry |
---|
Int'l Search Report and Written Opinion dated Nov. 8, 2017 in Int'l Application No. PCT/IL2017/050903. |
Grifols Vial Adapter Product Literature, 2 pages, Jan. 2002. cited by other. |
Novel Transfer, Mixing and Drug Delivery Systems, MOP Medimop Medical Projects Ltd. Catalog, 4 pages, Rev. 4, 2004. cited by other. |
Smart Site.RTM. Alaris Medical Systems Product Brochure, 4 pages, Issue 1, Oct. 1999. cited by other. |
MixJect, downloaded from webpage: http://www.westpharma.com/en/products/pages/Mixject.aspx, Download Date: Aug. 8, 2012, 1 page. |
MixJet Product Information Sheet, downloaded from webpage: http://www.westpharma.com/SiteCollectionDocuments/Recon/mixject%20product%20sheet.pdf; 1 page. |
The MixJect transfer system, as shown in the article, “Advanced Delivery Devices,” Drug Delivery Technology Jul./Aug. 2007 vol. 7 No. 7 [on-line]. [Retrieved from Internet May 14, 2020 URL: <http://www.drugdeiverytech-online.com/drugdelivery/200707/?pg=28pg28>. (3 pages). |
Silicone Rubber Overview Downloaded from webpage: http://www.knovel.com/web/portal/browse/display?_EXT_KNOVEL_DISPLAY_bookid=1023&VerticalID=0 on Feb. 9, 2011, Download Date: Sep. 2, 2011, Original Posting Date: 2010, 6 pages. |
Kipp, “Plastic Material Data Sheets,” retrieved from the internet: http://www.knovel.com/web/portal/browse/display?_EXT_KNOVEL_DISPLAY_bookid=1023&VerticallD=0, retrieved on Feb. 9, 2011. |
Alaris Medical Systems Product Brochure, 4 pages, Issue 1, Oct. 11, 1999. |
Smart Site Needle-Free Systems, Alaris Medical Systems Webpage, 4 pages, Feb. 2006. |
Photographs of Alaris Medical Systems SmartSite.RTM. device, 5 pages, 2002. |
Non-Vented Vial Access Pin with Ultrasite.RTM. Valve, B. Braun Medical, Inc. website and product description, 3 pages, Feb. 2006. |
Drug Administration Systems product information sheets; http://www.westpharma.com/eu/en/products/Pages/Vial2Bag.aspx; pp. 1-3 (admitted prior art). |
Article with picture of West Pharmaceutical Services' Vial2Bag Needleless System, [on-line]; ISIPS Newsletter, Oct. 26, 2007]; retrieved from Internet Feb. 16, 2010]; URL:<http://www.isips.org/reports/ISIPS_Newsletter_October_26_2007. html.> (7 pages. see pp. 5-6). |
West, Vial2Bag DC system, Oct. 2, 2014, https://web.archive.org/web/20141002065133/http://www.westpharma.cornien/products/Pages/Reconstitutionsystems.aspx. |
Vial2Bag DC, downloaded from webpage: https://www.youtube.com/watch?v=FEOkglxNBrs, Original posting date: Aug. 21, 2014, 1 page. |
Vial-Mate Adapter Device, Baxter, May 2017, downloaded from web page:http://www.baxtermedicationdeliveryproducts.com/drug-delivery/vialmate.html, Download Date: Jul. 28, 2017, original posting late: unknown, 1page. |
Summit International Medical Technologies Inc., Vial Direct to Bag Spike 2020. |
Merchant “An engineered control device for needle free reconstitution and transfer of compounded sterile intravenous drug solutions for immediate use to assist in complying with United States Pharmacopeia Chapter <797> standard”, Adv Care, 2 pages, 2018. |
Number | Date | Country | |
---|---|---|---|
20190201290 A1 | Jul 2019 | US |