Patent Application
20140020685
The present invention relates to a system for collecting nitrous oxide in air exhaled (=exhalation air) by one or more individuals and subsequently delivering the nitrous oxide to an apparatus for further processing. The invention comprises the system as such, a method of using the system, an adsorption unit containing a reversible nitrous oxide adsorbent, and a pool of such units.
Nitrous oxide is an air pollutant which is considered at least 300 times more effective than carbon dioxide as a “green house gas”. The gas is considered hazardous for people exposed to it during work (e.g. doctors, dentists, nurses etc). Occupational health limits have been set to 25 ppm. Cost-effective and convenient apparatuses, systems and methods for reducing discharge of the gas to the atmosphere are likely to be imperative in the future.
Within health care units, nitrous oxide is used within surgery, dental care, maternity care during delivery etc due to its anaesthetic and analgesic effect. The patient is allowed to inhale a gas mixture (=inhalation air) in which the main components are nitrous oxide, typically in concentrations ≧10%, such as ≧20% and/or ≦80%, such as ≦70% (v/v) and oxygen. The levels of nitrous oxide and oxygen are essentially the same for inhalation air and exhalation air. The levels of moisture (H2O) and carbon dioxide are increased in exhalation air compared to inhalation air. When an enhanced anaesthetic effect is desired, the mixture also contains a gaseous anaesthetic agent, as a rule in concentrations ≦10%, such as ≦5% or ≦2% with typically levels being in the range of 0.25-3%, such as 0.5-2% (v/v). Suitable anaesthetic agents have been selected amongst volatile halo-containing organic compounds, e.g. halo-containing hydrocarbons, halo-containing ethers etc, and other volatile and/or gaseous organic compounds which are capable of exerting an anaesthetic effect, for instance anaesthetic hydrocarbons not containing halo substituents.
At larger health care units exhalation air containing nitrous oxide is typically handled in a waste gas handling system which is common for several rooms/patients. In these kind of systems the exhaled air is typically diluted with ambient air (e.g. 10-50 times) and finally treated for removal of nitrous oxide at the health care unit and/or passed into ambient atmosphere.
Catalytic removal of nitrous oxide from exhaled air from patients has been discussed: DE 42087521 (Carl Heyer GmbH), DE 4308940 (Carl Heyer GmbH), EP 2165756 (Linde AG), U.S. Pat. No. 4,259,303 (Kuraray Co., Ltd), WO 2011075033 (Nordic Gas cleaning AB), WO 20101071538 (Nordic Gas Cleaning AB), WO 2010081642 (Linde AG), WO 2010081643 (Linde AG), WO 2006059506 (U.S. Pat. No. 7,608,232; Showa Denko KK), WO 2002026355 (U.S. Pat. No. 7,235,222, U.S. Pat. No. 7,597,858; Showa Denko KK), JP publ No. 55-031463 (Kuraray Co Ltd), JP publ No. 56-011067 (Kuraray Co Ltd), JP publ No. 2006230795 (Asahi Kasei Chemicals Corp).
An experimental study on adsorption of nitrous oxide in ventilation air by the use of zeolites is given in “Removal of laughing gas from air by the use of zeolites” IVL commission for Stockholms Läns Landsting, www.sll.se: Report 2007-Mar.-8.
The publications given above are mainly focusing on removal of nitrous oxide by catalytic decomposition, adsorption or compression/condensation.
At smaller health care units and/or during minor treatments requiring short-time inhalation of nitrous oxide it is neither cost effective nor convenient to use the equipments used for larger units. For smaller units and minor treatments it becomes inconvenient and expensive with a common system for handling and/or decomposition of waste anaesthetic gases. The levels of nitrous oxide to deal with will be inherently higher which is associated with its own problems. Typical smaller health care units and minor treatments are e.g. ambulances, dentists, private doctors, local health centres, acute clinics etc. Previously suggested apparatuses and methods have typically been adapted for use close to a patient and are in many cases based on adsorption; see for instance WO 2009095601, WO 2009095605 and WO 2009095611 (all of Air Liquid). See also EP 0284227 (Union Carbide), EP 1356840 (Siemens-Elema), and EP 1797942 (Univ Delft), international patent application PCT/SE2011/000202 (Nordic Gas Cleaning AB), U.S. Pat. No. 3,941,573 (Chapel) and U.S. Pat. No. 5,928,411 (Drägerwerk). Mobile docking arrangements as generically defined in this specification are also included in the mobile adsorbtion units described in WO 2009095601, WO 2009095605 and WO 2009095611.
See also Removal of laughing gas from air at dentists by the use of zeolites “Stockholms läns landsting SSL—Occupational Health, www.sll.se: Report 2010-Jun.-10:”
EP 2165756 (Linde AG) expressly discusses close-to patient use and temperature regulation during exothermic decomposition of nitrous oxide.
There is a need for more cost-effective and convenient systems and methods for collecting nitrous oxide from exhaled air of single patients at health care units and subsequent further processing of nitrous oxide to environmentally acceptable end products. These systems should a) be adapted for use close to a patient, b) be flexible and simple to manufacture and use, c) support favourable total energy balance, d) support discharge of acceptable levels of harmful substances to the environment (e.g. nitrous oxide and NOx (x=1 och/eller 2)) etc.
All patents and patent applications cited in this specification are hereby incorporated in their entirety by reference.
The main object of the invention comprises to provide convenient and cost effective systems and methods for handling of nitrous oxide collected from exhaled air as discussed above.
Flow directions are indicated with arrows (in
The inventor has realized that the objects given above can be met for the systems and methods that are generally defined under Technical Field by including a pool of one, two or more through-flow nitrous oxide adsorption units (101,201,301) which are mutually replaceable (if there are two or more of them in the pool), together with
The individual adsorption units are mobile. At least docking arrangement DAads for adsorption may be mobile and have simple design. See below.
The expression “for connecting” means both “is connected” and “is capable of being connected”. The connection may be indirect or direct where indirect includes via a functionality, e.g. via valves, heaters, flow changing functions, filters etc and direct means via simple connections and/or extension conduits without any particular functionality other than transportation of gas/fluid. This applies all throughout the specification if not otherwise indicated.
The expression “mutually replaceable” means that corresponding parts of individual adsorption units of the pool have the same geometrical fit for the system, e.g. with respect to geometry of inlet ports and outlet ports, connections to docking arrangements, connections to sensors etc. It also means that the individual adsorption units are mobile between a docking arrangement DAads and a docking arrangement DAdes, i.e. between different possible locations of individuals inhaling nitrous oxide and/or between such a location and an apparatus for further processing of nitrous oxide. Corresponding definition also applies to variants of the inventive system comprising several DAabs and/or several DAdes.
The expression “further processing” encompasses e.g. decomposition, pooling, storing and the like of nitrous oxide adsorbed in an adsorption unit. Pooling and/or storing are possibly combined with condensation/compression/fractionation. There are a number known apparatus and methods for performing further processing; see the publications discussed above and recently filed SE 1130018-3 filed Mar. 24, 2011 and U.S. 61/469,381 filed Mar. 30, 2011 and corresponding international patent application filed in parallel with this application (all three with the title Apparatus for treating gas with Nordic Gas Cleaning AB as proprietor and Istvan Szábó as inventor).
The first aspect of the invention is a system for carrying out a method comprising the steps of:
Inhalation/exhalation of nitrous oxide is done via a face mask arrangement (204) (further on called “face mask”) which comprises an inlet ILmask (211) for inhalation and an outlet OLmask (212) for exhalation plus the face mask as such together with various arrangements supporting and facilitating undisturbed breathing when the mask is used. The velocity for exhaled air leaving a face mask arrangement is typically within the interval of 15-40 L/min, such as 20-30 L/min.
The main characteristic feature is that the system comprises a pool containing one, two or more adsorption units (201,201′,202″ etc) together with arrangements A+B, preferably combined with C and/or D.
In addition to nitrous oxide adsorption units the pool may also contain other adsorption units, e.g. for adsorbing anaesthetic agents, moisture etc. The term “adsorption unit” will further on only refer to “mobile and mutually replaceable and reversible nitrous oxide adsorption units”, if not otherwise indicated by the context.
An adsorption unit (101,201,301) has a through-flow adsorption chamber (113,213,313) which contains a through-flow nitrous oxide reversible adsorbent (113a,213a,313a) placed in the chamber typically leaving a gap (113b,c,213b,c,313b,c) devoid of adsorbent at each end of the chamber. The unit also has:
The inlet port IPads (114a,214a,314a) and the outlet port OPads (114b,214b,314b) of a unit define the flow direction Flowads of the adsorption flow through the chamber/unit/adsorbent. The two ports are placed at opposite ends/parts of the chamber/unit/adsorbent and accordingly define an upstream end/part and a downstream end/part in relation to the adsorption flow.
The inlet port IPdes (115a,215a,315a) and the outlet port OPdes (115b,215b,315b) of the unit define the flow direction Flowdes for the desorption flow through the chamber/unit/adsorbent. The two ports are placed at opposite ends/parts of the chamber/unit/adsorbent and accordingly define an upstream end/part and a downstream end/part in relation to the desorption flow.
The flow directions Flowads and Flowdes may have the same or opposite directions through the chamber (413). The inlet ports IPads and IPdes (114a,214a,314a and 115a,215a,315a) for the adsorption flow and the desorption flow, respectively, may be i) at opposite ends or ii) at the same end of the chamber/unit/adsorbent, where (i) means opposite directions for the flows and (ii) the same direction for the flows. The same applies for the outlet ports OPads and OPdes (114b,214b, 314b and 115b,215b,315b). A convenient arrangement is that ports pair-wise coincide, e.g.
The directions in space of the two flows can be vertical or horizontal. Vertical directions are preferred and include a) vertically upwards with an angle between the flow direction and the vertical line being within ±45° preferably 0°, and b) vertically downwards with a corresponding interval of 180°±45°, preferably 180°. Intervals of the same widths are valid for downwardly and upwardly directed horizontal flows.
For adsorption/desorption under flow conditions in general it is considered to be optimal to reverse the flow direction when switching from adsorption to desorption. This principle also applies to adsorption/desorption in the present invention. However, the system of the invention might be simpler, more convenient, more cost-effective etc to use with the same flow direction for adsorption and desorption, i.e. the adsorption unit is constructed as illustrated in
The gaps/empty spaces (113b,c,213b,c,313b,c) cover the ends of the adsorbent in order to support even distribution of adsorption flow/exhalation air and/or desorbing flow/gas through the adsorbent (113,a,213a,313a). Placed at an upstream end the gap is an example of a distributor function. Placed at a downstream end the gap is an example of a collector function. As illustrated in
The adsorption unit may also comprise an inlet conduit (116a,216a,316a,117a,217a,317a) for each inlet port (114a,214a,314a,115a,215a,315a) and/or an outlet conduit (116b,216b,316b, 117b,217b,317b) for each outlet port (114b,214b,314b, 115b,215b,315b) for gas flow communication between the chamber and the inlet ports and the outlet ports, respectively. These conduits may coincide forming a common conduit in the same manner as the inlet/outlet ports with the same preferences as for the ports. A common outlet/outlet conduit, inlet/outlet conduit, or inlet/inlet conduit may comprise that the common conduit divide into two branch conduits each of which ends in an inlet or outlet port according to the two functions of the common conduit. This kind of branching is typically associated with a valve function permitting separate opening of each of the two branch conduits while at the same time leaving the common conduit open. Theoretically the branching may be the other way round, i.e. with both branches ending at the decomposition chamber (313).
The adsorption unit (201,201,301) may also contain other functionalities as discussed below, e.g. carrier functions (318a,318), an air inlet (325), a flow changing function (324), one or more valves, one or more sensors (308a,b,c), parts of a logging arrangement (309b,310a) such as a memory etc.
The total volume of the adsorbent (113a,213a,313a) should be sufficient for two or more separate medical treatments with administration of nitrous oxide lasting for about 15 minutes each (mean administration times). A typical range is 10-50 separate treatments. This means that the amount of adsorbent per adsorption unit should be sufficient for a total effective collecting time in the interval of >30 min with a typical interval of 50-750 min. For adsorbents of essentially the same bulk density (660-740 g/L), particle size (1.5-2.5 mm) and specific capacity (0.075 g N2O/g adsorbent) as the adsorbent used in the experimental part, this means that suitable volumes may be found in the interval of 5-30 L per adsorption unit with a weight in the interval of roughly from 1-2 kg to 20 kg. For adsorbents having other densities, particle sizes and capacities per unit volume, suitable intervals for weights and volumes may be found by adapting these general guidelines to the actual densities, particle sizes and specific capacities of these other adsorbents.
The outer dimensions of the chamber including isolation, walls and the like are typically: a) the height (along the flow direction) is typically >10 cm such as within the interval of 20-180 cm, and b) the cross-sectional area (orthogonal to the flow direction) corresponds to a circular cross-sectional area with a diameter >5 cm, such as within the interval of 10-100 cm, such as 10-80 cm. The shape of the cross-sectional area of the unit as well as of the chamber and the adsorbent is preferably circular.
The adsorbent (113a,213a,313a) is typically in the form of a porous bed. This bed preferably comprises a bed of packed particles, preferably porous particles, e.g. comprising chemistry and/or micropores in a size range classifying the material as a molecular sieve. Suitable micopore sizes are found in the interval of 1-12 Ångström for removing nitrous oxide from a gas stream which contains exhalation air, i.e. nitrous oxide together with oxygen and typically also moisture (H2O) and/or carbon dioxide. The particles shall have sizes such that the void volume between the particles when packed to a bed defines a through-passing macroporous system which permits flow transport of inhalation air and desorbing gas through the bed. Suitable particle sizes for particulate materials are found within the interval of 0.5-10 mm, with preference for within 1-5 mm (diameters). This includes that a minor part of the particle material may be particles with sizes outside these ranges, e.g. <25% or <10% or <5% or <1%. The particles are preferably spheroidal, i.e. rounded including in particular beaded forms such as in the form spheres.
The adsorbent (113a,213a,313a) may alternatively be a macroporous monolith or plug exhibiting micropores of the sizes given above for particles.
Suitable adsorbent materials are found amongst materials of the above-mentioned type having a capacity for adsorbing nitrous oxide in the interval of 0.025-0.25 g of N2O/g adsorbent material.
Suitable adsorbent material should be stable under the temperatures applied during adsorption and desorption, i.e. from around 15-20° C. to the upper temperatures given for desorption.
The adsorbent (113a,213a,313a) is reversible with respect to adsorption/desorption. In other words it can be regenerated after adsorption to give an adsorbent having sufficient adsorbing capacity for nitrous oxide and through-flow capacity for being reused in the system of the invention. The regeneration is carried out by passing a desorbing gas, preferably heated, through the adsorbent to desorb nitrous oxide. The adsorbent material should preferably allow for regeneration at least 5 or at least 10 or at least 15 or at least 20 times with a retained capacity of ≧50%, such as ≧60% or ≧75% of the initial capacity for removing, binding or adsorbing nitrous oxide from exhalation air.
An important class of adsorbent material are zeolites which may be either natural zeolites or more preferably modified zeolites, e.g. with native Na+ ions being replaced with Ca2+ ions.
Suitable materials can be obtained from among others Merck, Darmstadt, Germany (Moleculare sieve 0.5 nm) and Grace Davison, Grace GmbH, Worms, Germany (Molecular sieves MS S 624).
Further guidelines for selecting adsorbent materials to be used in the invention are found in literature related to adsorption of nitrous oxide from industrial off-gases (e.g. U.S. Pat. No. 6,080,266 UOP LLC, U.S. Pat. No. 6,719,827 Air Products and Chemicals Inc, US 20100071552 Virani et al etc) and from exhalation air (e.g. WO 2009095601, WO 2009095605 and WO 2009095611 all of Air Liquid, U.S. Pat. No. 3,941,573 Chapel, U.S. Pat. No. 5,928,411 Drägerwerk, U.S. Pat. No. 3,941,573 Chapel). See also Stockholms läns landsting www.sll.se Report 2007-Mar.-8 “Removal of laughing gas from air by the use zeolites”, and Report 2010-Jun.-10: “Removal of laughing gas from air at dentists by using zeolites” (both reports compiled by IVL))
Reversible nitrous oxide adsorbents (113a,213a,313a) for which there is a measurable parameter which changes as a function of the proceeding of the adsorption of nitrous oxide are likely to have a great potential for use in the invention. By selecting this kind of adsorbent together with an appropriate sensor (308a,b,c) it may be possible to measure when the proceeding of the adsorption front has reached one or more predetermined position along the flow direction in the adsorbent during an ongoing adsorption (position=longitudinal position). Every such position will represent utilized capacity (=a particular degree of utilization of the capacity) or of remaining capacity to utilize (=available capacity) when the front reaches the position. The outlet end of the adsorbent will mean that 100% has been utilized with no remaining capacity to utilize. Other predetermined positions may stand for e.g. ≧50%, ≧75%, ≧85%, ≧90% of the initial capacity is utilized (or ≦50%, ≦25%≦15%, ≦10% of the initial capacity remains to be utilized or is still available). A finding that the adsorption front has reached a certain position can be used for alerting personnel handling the system to disconnect the unit and initiate subsequent desorption and further processing of desorbed nitrous oxide. Changes in the time needed for the adsorption zone to reach a certain predetermined position between repetitive occasions of use of the same adsorbent/unit will be indicative about the latest status of the working efficiency of the adsorbent/unit. It can be envisaged that this might be used for determining when an adsorbent/adsorption unit needs be discarded/repacked with fresh adsorbent material.
The adsorption unit may also have a memory (310b) which is part of the memory (310a+b) of a logging arrangement (309a+b) of the system of the invention as discussed under D. Logging arrangement below. Other parts of the adsorption unit of the invention are
Every adsorption unit of the pool typically comprises a carrier function (318) comprising e.g.
a) wheels (318a) and/or one or more handles (318b) fixedly mounted on the vessel containing the chamber/adsorbent, or b) a cart for carrying the vessel, which contains the adsorbent, and other parts of the unit as discussed above and below.
Docking arrangement DAads (202) is associated with the adsorption of nitrous oxide. The arrangement is adapted for connecting a face mask (204) of an individual exhaling nitrous oxide to a waste recipient (205) for exhaled air depleted in nitrous oxide via an adsorption unit (201). A typical docking arrangement DAads (202) comprises:
Exhaled air depleted in nitrous oxide thus may be discharged directly from the outlet port OPads (214b) to ambient atmosphere. This can render the connection C2ads (219b) obsolete, i.e. preferred variants are devoid of this optional connection.
The system can have one, two or more of docking arrangement DAads (202) for use at different locations of a health care unit. The arrangement DAads is preferably mobile in the sense that it can be disconnected/reconnected from/to a face mask and transported with or with the face mask connected to between patients and/or locations where there is a need for administering nitrous oxide. See also Developments during the priority year at the end of this specification where we describe a simple variant which can be transported together with the adsorprtion unit. Compare also WO 2009095601, WO 2009095605 and WO 2009095611 discussed above.
Docking arrangement DAdes (203) is associated with desorption of nitrous oxide by passing a desorbing gas through an adsorption unit. The arrangement (203) is thus adapted for connecting a source (206) of desorbing gas to an apparatus for further processing of nitrous oxide via an adsorption unit (201) (which have been charged with nitrous oxide in docking arrangement DAads (202)). A typical docking arrangement DAdes comprises
The source for desorbing gas has been discussed above together with the inlet port IPdes. (215a). Air from ambient atmosphere (206) may be used directly as desorbing gas without any preprocessing. The need for connection C1des (220a) may then be obsolete, i.e. preferred variants are devoid of this optional connection.
Either one or both of the docking arrangements DAads (202) and DAdes (203) may comprise a flow changing function (223a,b), a heating function (222), valve functions, a sensor (208a,b) etc.
See also Developments during the priority year at the end of this specification.
The system is preferably associated with a measuring arrangement which comprises one or more sensors (208a,b,308a,b,c). These arrangement/sensors are capable of measuring amounts of nitrous oxide retained in the individual adsorbents during and/or after adsorption. The sensors may be based on measuring changes in weight (208a,b) of an adsorbent/unit, changes in available and/or utilized capacity (308a,b,c) and/or other parameters changing as a consequence of the adsorption, e.g. the position of the adsorption front (308a,b,c) during ongoing adsorption, changes in level of nitrous oxide in the adsorption flow downstream of the adsorbent (e.g. break-through or the level downstream of the adsorbent relative the level upstream of the adsorbent), changes in temperature (308a,b,c) in the adsorbent due to evolution of heat during adsorption (see above) etc. Thus a typical sensor used in the measuring arrangement may be a weight sensor (208a,b), a spectrometric sensor, a temperature sensor (308a,b,c) etc. A spectrometric sensor is illustrated with an IR sensor in the Experimental Part.
In principle every parameter for which a measurable change also indicates a measurable change in amount of nitrous oxide retained on the adsorbent can be used. Sensors measuring consumption of nitrous oxide, such as number of exhalations/inhalation (sensor: a pulse meter), lowering of amount of nitrous oxide in the source (221) of nitrous oxide etc, could also be included in the measuring arrangement. With respect to number of inhalations/exhalations, individuals most likely will have to be grouped, e.g. according to weight, sex, age, health status, etc where every group have a relatively narrow interval for volume of inhaled air per inhalation/exhalation.
In one variant of the measuring arrangement, there is a sensor (208a,b) which is common for several adsorption units (201). Sensors (208a,b) in arrangements of this kind may be based on weighing (scales, changes in weight) and may be part of A) the apparatus for further processing (207), B) docking arrangement DAads (202), and/or C) docking arrangements DAdes (203). Other possible sensors (common to several adsorption units (201)) are: Sensors based on consumption of nitrous oxide (measured e.g. at the source (221) of nitrous oxide) and number of inhalations/exhalations (measured at the face mask (204, for instance), spectrometric sensor, e.g. an IR sensor placed in the gas flow downstream of C2ads (219b) (provided this optional connection is present) etc.
In another variant, every individual adsorption unit (308a,b,c) is associated with its own sensor. This kind of arrangement is preferably based on sensors measuring temperature changes or other changes in the adsorbent due to adsorption, and/or changes in the level of nitrous oxide in the adsorption flow downstream of the adsorbent but still within the adsorption unit (primarily only break-through). Other possible sensor types to be used on individual adsorption units can be found among those mentioned above for the measuring arrangement in general, for instance weight sensors, such as load cells, spectrometric sensors, such as IR sensors, etc
A potentially interesting variant comprises one, two or more temperature sensors (308a,b,c) placed at different downstream positions in an adsorbent (313a) for which adsorption of nitrous oxide is exothermic; see above under The pool of adsorption units, subheading Adsorbents. This implies a variant of the present invention which comprises that
One predetermined position can be in the central part and second position close to the outlet of the adsorbent (313a). This corresponds to about 50% and about 10% of the total capacity still being available downstream of the first and second position, respectively. Future results are likely to show that either upward flow or downward flow is to be preferred.
The system of the invention typically comprises a logging arrangement (309a+b) for
This implies that the system of the invention also may include an appropriate alarm function for this purpose.
A central part of the logging arrangement is a memory (310a+b) for storing
Stored data of type (b) refer to values obtained by the measuring arrangement and include also data which are derived from such values. In particular adsorption capacity data and/or flow property data (e.g. pressure drop at the working conditions) may be stored.
Data of type b) include capacity data relating to adsorption of nitrous oxide and/or flow capacity data and/or sum of running times for adsorption for at least the latest time of use for the individual adsorbents of the pool etc, and possibly also corresponding initial values for freshly prepared adsorbents of the pool.
The memory of the arrangement may comprise local memories (310b) (one or more per adsorption unit (301)) and/or a central memory (310a) separate from the local memories. A local memory may be physically attached to or physically separated from its adsorption unit and/or typically contains the unique identification code for the unit possibly together with other information collected at least for the latest time of use of the unit, or a reference to such information in a central memory for instance via the identification code. The central memory (310a) typically includes the necessary information for keeping track of important changes in unity-specific data of the kind mentioned in the previous paragraphs. Alternatively the central memory only contains the identification code and collects all or a part of the unit-specific data from the appropriate local memories by referring to this code.
The local memories and/or the central memory may be in the form of a conventional log-book or label with the stored information in typed-out form, or as readable and/or writeable electronic memories or the like. Transmission of information between the memories may be wire-less or via wires.
The heating arrangement comprises one or more functions (222,322) each of which is capable of heating the adsorbent in every adsorption unit to effectuate quick and efficient desorption when a unit is connected for desorption. Heating may take place via direct heating of the adsorbent, e.g. micro-wave heating, or by preheating the desorbing gas upstream of the adsorbent.
In one main variant there is a heating function (322) in the individual adsorption units (301). This heating function is then preferably placed between the inlet port IPdes (315a) for the desorption flow and the adsorbent (313a), preferably in the upstream end of the chamber (313), e.g. in the gap (313c), or in the inlet conduit (317a) for the desorption flow.
In another main variant the heating function (222) is common to several adsorption units. The position for the heating function (222) is then preferably upstream of the connection C1des (220a) of docking arrangement DAdes (203).
In the case there is a flow changing function FCFdes downstream of a heating function, there should be a cooling function between the heating function and the flow changing function. In order for the heated desorbing gas to effectuate desorption, this means that both the cooling function and the flow changing function FCFdes should be placed downstream of the adsorbent (213). This in particular applies if the flow changing function FCFdes is a blower since conventional blowers are normally not designed to resist preheated gas flows. At the priority filing it was felt that this cooling function should be avoided on the adsorption units (201) and it was therefore at that time preferred to place such a cooling function and the flow changing function on docking arrangement DAdes (203) or in the apparatus for further processing (207). This view has been changed during the priority year. See Developments during the priority year at the end of this specification (
A heating function (222,322) shall be capable of heating the through-passing desorbing gas and/or the adsorbent (313a) to a temperature enabling efficient release of nitrous oxide from the adsorbent. Suitable temperatures depend on the desorbing gas, adsorbent material etc, and are typically found in the interval of ≦400° C., such as 100-400° C. or 100-250° C. The effect of the heating function at least for preheating should be within the interval of 150-2500 W with preference for within 200-500 W. The heater may be gradually adjustable with respect to effect and is preferably in the form of an electrical heating element possibly supported by a heat exchanger as described under Developments during the priority year at the end of this specification.
The system of the invention is associated with a flow regulating arrangement which comprises two parts: An adsorption part and a desorption part. The arrangement comprises various flow functions, such as flow changing functions FCF, valves, vents to air etc. The major part of these functions are part of the apparatus (207) for further processing, the face mask arrangement (204), the source (206) for desorbing gas and/or the waste recipient (205) all of which as such are well known in the field. The remaining flow functions, if any, are present on the adsorption units (201) and/or the docking arrangements DAads (202) and/or DAdes (203). A general rule is to place as few flow functions as possible on the mobile adsorption units.
Flow changing functions FCF are used for initiating, stopping, increasing and/or decreasing flow velocity. In the adsorption part they are called FCFads and in the desorption part FCFdes. Flow changing functions are preferably blowers and/or preferably frequency controlled and/or preferably gradually adjustable with respect to flow velocity. This applies to in principle every flow changing function which is part of the flow regulating arrangement and is independent of position in the arrangement.
A predicted preferred variant of the invention presumes that the flow of exhalation air (=adsorption flow) leaving a face mask arrangement (204) is sufficient for the flow to pass through the adsorption unit (201). However, this will require a sufficiently stable adsorption flow (exhaled air) both during the treatment of an individual and between treatments and/or individuals. The system of the invention is therefore likely to become more versatile if a flow changing function FCFads is included in the adsorption part of the flow regulating arrangement, e.g. as indicated in the variants illustrated by
In one variant a flow changing function FCFads (223a) is common to several adsorption units (201). This means that the function is present a) on the face mask arrangement (204), b) on the docking arrangements DAads (202) upstream of the connection C1ads (219a) and/or downstream of the connection C2ads (219b) and/or c) on the arrangement for the waste recipient (205). Preferred positions for this variant are (b) or (c).
In other variants of the invention, individual adsorption units comprise a flow changing function FCFads (324). This means that the flow changing function FCFads (324,423) when present on the unit (301,401) is always placed between the inlet port IPads (314a,414a) and the outlet port OPads (315b,415,b). Typical positions are in the inlet or outlet conduits (116a,216a,316a and 117b,217b,317b, respectively).
A variant thought to be advantageous at the priority date comprises a flow changing function FCFads (324) placed upstream or downstream of the adsorbent (313a) in combination with an air inlet (325) placed upstream of the flow function FCFads (324). The preferred positions for the air inlet (325) and the function FCFads (324) are in the inlet conduit (316a) as illustrated in
The arrangement described in the preceding paragraph may also be used for the desorption flow, see
At the end of the priority year a simpler alternative to the inlet/outlet function illustrated in
In one variant a flow changing function FCFdes (223b) for desorption flow may be common for several adsorption units. This variant means that the flow changing function may be placed
This is illustrated in
In other variants of the invention, individual adsorption units comprise a flow changing function FCFdes which may be present between an inlet port IPdes (115a,215a,315a) and the adsorbent (113a,213a,313a) and/or between the same adsorbent and an outlet port OPdes (115b,215b,315b). The preference is for in the inlet or outlet conduits (116a,216a,316a and 117b,217b,317b, respectively).
In
See also Developments during the priority year at the end of this specification (
The system may also contain a pool of one or more mutually replaceable adsorption units for removing an anaesthetic agent present together with nitrous oxide in an anaesthetic gas (not shown). The system then encompasses the appropriate docking arrangement on which these units may be replaceable inserted/displaced. This docking arrangement may be placed upstream of the connection C1ads (219a) of the docking arrangement DAads (202), such as within the docking arrangement. Alternatively the chamber or unit with an adsorbent for an anaesthetic agent may be present on the adsorption unit carrying a nitrous oxide adsorbent. This chamber then may be combined with the chamber for the nitrous oxide adsorbent or as a separate chamber/adsorbent The adsorbent for the anaesthetic agent is then preferably placed upstream of the nitrous oxide adsorbent.
The system may also comprise a function for removing particles (filter function, not shown) and/or a function for removing moisture (moisture adsorbent, e.g. silica material, not shown) from the incoming adsorption flow (exhalation air). When these functions are present in the system they may be connected (=placed) upstream of the adsorption unit for nitrous oxide and the possible adsorption unit for removal of an anaesthetic agent. A filter function and/or a moisture adsorbent are preferably placed upstream of the connection C1ads (219a) of docking arrangement DAads (202) and/or upstream of the connection C1des (220a) of docking arrangement DAdes (203), and preferably as a part of a docking arrangement. In the case adsorption units for an anaesthetic agent are included in the inventive system, a particle filter function and a moisture adsorbent, if present, should be placed upstream such extra adsorption units.
This aspect is a method in which the system described above is used for the purpose discussed for the system aspect of the invention. The method comprises the steps of:
Preferences in the method are mentioned in the description of the system aspect of the invention.
A preferred method aspect comprises that a unit is disqualified based on capacity and/or flow property data derived from measurements made by the measuring arrangement of the system and/or by general guidelines, e.g. given by the manufacturer. Measurement of capacity and flow properties has been discussed above. General guidelines of interest may have been set up empirically, and typically comprise a) an upper limit for number of regeneration cycles for an adsorption unit/adsorbent, b) a maximum total time for adsorption (sum for all cycles run with a particular adsorption unit), c) the time needed for reaching a predetermined saturation level, d) a minimum available total capacity in absolute amount or in relation to available total capacity before or found after the first time the adsorption unit is used in the inventive system etc.
Measured values as well as predetermined limit values etc are typically stored in the memory of the logging arrangement of the system. See above under Logging Arrangement
A third aspect of the invention is an adsorption unit as generally defined in original claim 1 with the characteristic features as given in subclaims and elsewhere in this specification.
We have concluded from developments during the priority year that for the most convenient variants of docking arrangements:
These kinds of docking arrangements are in particular adapted to the variants of adsorption units illustrated by
There is an imperative adsorption chamber (413) containing the adsorbent (413a) for nitrous oxide between the ports. This chamber preferably has a gap (413b and 413c) at each end of the bed (413a).
Between the common inlet/outlet port IPads/OPdes (414a/415b) and the chamber (413) there is an inlet/outlet conduit (416a/417b) which is common for exhaled air and desorbing gas in the same manner as the common inlet/outlet port IPads/OPdes. This inlet/outlet conduit may be designed with two common inlet branches (416a′/417b′ and 416a″/417a″) with corresponding branch inlet ports (414a′/415b′ and 414a″/415b″, respectively) in order to be adapted to a patient which is alternately inhaling/exhaling a nitrous oxide mixture and oxygen or air via two separate face masks. This kind of branching/merging (435) may be placed on the adsorption unit (401) as illustrated in this figure. Alternatively it is placed upstream of the adsorption unit (not shown), e.g. upstream of the connection C1ads of a docking arrangement DAads, and is then only used for merging the flow of nitrous oxide with the flow not containing nitrous oxide (oxygen or air). Alternatively the branching/merging may be an integrated part of a face mask (only merging). Upstream refers to the adsorption flow. In other variants of the invention, the common inlet/outlet port IPads/OPdes (414a/415b) may be a single port as illustrated in
The branching/merging function (435) may be associated with a valve function enabling separate opening of each of the two branches/ports or simultaneous opening of them depending on the number of different flows (one or two) entering the unit and how they are going to be treated in the unit. This valve function, if present, is preferably simple, e.g. separate closing/opening of a desired one of the two inlet/outlet ports (414a′/415b′ and 414a″/415b″) by a plug or a cover, or a true valve encompassing closing/opening at the merging point or within the branch conduits.
The common outlet/inlet port OPads/IPdes (414b/415a) is typically a single port with a single outlet/inlet conduit (416b/417a) between this port and the adsorption chamber (413). The outlet/inlet conduit (416a/417b) is common for the exhaled air and desorbing gas in the same manner as the common inlet port OPads/IPdes.
There is also a heating arrangement (422a+422b) for heating the desorbing gas before it enters the adsorbent (413a). This arrangement is only used during desorption mode, i.e. at least the heater (422b) is turned on during desorption. This kind of heating arrangement is generally in the invention and comprises:
The heat exchanger (422a) will thus exert a cooling function (422a′) on desorbing gas downstream of the adsorbent and a heating function (422a″) on desorbing gas upstream of the adsorbent. This heat exchanger corresponds to the cooling function disclosed in the priority application. It preferably exerts its heating function (422a″) upstream of the heater (422b).
The heat exchanger (422a) is preferably used as a heating complement to the heater (422b) and will
The flow changing function for controlling desorption flow is advantageously placed on the apparatus for further processing (e.g. FCFdes (523) in
A flow changing function FCFads (423a) which is used to secure subpressure and hinder leakage of nitrous oxide at positions upstream of the adsorption unit is preferably placed on the unit (401). The preferred position in the adsorption unit (401) is upstream of the heater (422b) with further preference for also upstream of other parts of the heating arrangement (422a+b) that may be present, e.g. the heating function (422a″) of the heat exchanger (422a). This means that the most convenient position is in the common outlet/inlet conduit (416b/417a) through which exhaled air passes before entering the adsorption chamber (413). The flow changing function FCFads (423a) is capable of being turned off during desorption and turned on during adsorption. It is preferably battery-driven.
The flow changing functions in the two preceding paragraphs are preferably blowers of the same type as discussed as discussed elsewhere in this specification.
The preferred adsorption chamber (413) contains a porous adsorbent (413a) surrounded by ends devoid of adsorbent materials (gaps, 413b and c). One, two or more sensors (408a,b) as part of a measuring arrangement may be placed on the unit, e.g. in the adsorbent (413a), for indicating in real time the saturation degree of the adsorbent during ongoing adsorption of nitrous oxide within the bed. See discussion above. These sensors are preferably temperature sensors which are placed in the adsorbent. There may alternatively be other kinds of sensors for indicating saturation degree or amount of nitrous oxide on the adsorbent as discussed elsewhere in this specification.
The various functional parts of the adsorption unit (401) discussed above are preferably enclosed in a common housing (426). The unit may be equipped with wheels to support mobility. One or two face masks for inhalation of gas containing nitrous oxide and/or oxygen/air, respectively, as well as gas tubes containing these gases may be connected and/or carried to/by a mobile unit which contains the inventive adsorption unit.
During adsorption the common inlet/outlet port IPads/OPdes (414a/415b) is connected to a face mask arrangement used by a patient inhaling nitrous oxide. The flow changing function FCFads (423a) is turned to secure subpressure upstream of the function and prevent leakage to the environment. Exhaled air is allowed to pass through the adsorbent while nitrous oxide is captured in the adsorbent. Exhaled air depleted in nitrous oxide is discharged to ambient atmosphere through the outlet/inlet port OPads/IPdes (414b/415a). The sensor for saturation (408a) indicates when a predetermined saturation degree of the adsorbent is reached (see discussion above) after which the adsorption unit (401) is disconnected from the face mask arrangement and regenerated by desorption. For temperature sensors as illustrated in
During desorption the inlet/outlet port IPads/OPdes (414a/415b) of an adsorption unit according to
During desorption the heater (422b) and the flow changing function FCFdes (423) on the adsorption unit (401) and the flow changing functions FCFdes (523), and FCF (521) and the heating arrangement (515) on the apparatus (500) are turned on. The flow changing functions FCFdes (423) and FCF (523), i.e. the desorption flow, is controlled by the flow sensor (525) on the decomposition apparatus to be within presets limits (cable between the adsorption unit and the decomposition apparatus). The sucking force will be the pressure differential caused by the flow changing functions FCFdes (523). The flow changing function FCFads (423) on the adsorption unit (401) is turned off during desorption of nitrous oxide. During desorption the adsorbent will be warmed up by the heater (422b) starting from the end next to the heater (422b) (100-200° C.). When the temperature at the sensor (408b) at the opposite end of the adsorbent has reached a predetermined value (about 100° C.) the heater (422b) is turned off Either one or both of the flow changing functions FCFdes (423) and FCF (523) is on for 1-2 additional hours in order to complete desorption (about 40° C. at temperature sensor (408a) at the outlet end of the adsorbent). The heater (422b) is controlled from the apparatus (500) (cable).
The two separate inlet conduits (502a,b) with the merger function (535) may be placed outside the inventive apparatus or does not need to be present if the patient is only using one face mask or if the gas to be processed in the apparatus does not contain exhalation air. Nitrous oxide may for instance be desorbed from an adsorbent previously loaded with nitrous oxide by passing exhalation air containing nitrous oxide through the adsorbent. See also discussion with respect to
As described elsewhere in this specification the various functions described above may be placed in a common housing (537). Parts/functions which will become warmed up during use of the apparatus should be properly heat insulated by the appropriate heat insulating material (518).
The apparatus may be equipped with wheels to support mobility. Proper face masks for inhalation of gas containing nitrous oxide and/or oxygen/air, respectively, as well as gas tubes containing these gases may be connected and/or carried to/by a mobile unit which contains the inventive apparatus.
These experiments were repeated 5 times with essentially the same results.
While the invention has been described and pointed out with reference to operative embodiments thereof, it will be understood by those skilled in the art that various changes, modifications, substitutions and omissions can be made without departing from the spirit of the invention. It is intended therefore that the invention embraces those equivalents within the scope of the claims which follow from this.
| Number | Date | Country | Kind |
|---|---|---|---|
| 1130018-3 | Mar 2011 | SE | national |
| 1130019-1 | Mar 2011 | SE | national |
| 1130026-6 | Apr 2011 | SE | national |
| Filing Document | Filing Date | Country | Kind | 371c Date |
|---|---|---|---|---|
| PCT/SE2012/000043 | 3/23/2012 | WO | 00 | 9/24/2013 |
| Number | Date | Country | |
|---|---|---|---|
| 61469369 | Mar 2011 | US | |
| 61469381 | Mar 2011 | US |
