Patent Grant
11744598
The present disclosure relates to medical devices and systems, and more particularly, systems for neuronavigation registration and robotic trajectory guidance, robotic surgery, and related methods and devices.
Position recognition systems for robot assisted surgeries are used to determine the position of and track a particular object in 3-dimensions (3D). In robot assisted surgeries, for example, certain objects, such as surgical instruments, need to be tracked with a high degree of precision as the instrument is being positioned and moved by a robot or by a physician, for example.
Position recognition systems may use passive and/or active sensors or markers for registering and tracking the positions of the objects. Using these sensors, the system may geometrically resolve the 3-dimensional position of the sensors based on information from or with respect to one or more cameras, signals, or sensors, etc. These surgical systems can therefore utilize position feedback to precisely guide movement of robotic arms and tools relative to a patients' surgical site. Thus, there is a need for a system that efficiently and accurately provide neuronavigation registration and robotic trajectory guidance in a surgical environment.
End-effectors used in robotic surgery may be limited to use in only certain procedures, or may suffer from other drawbacks or disadvantages.
Cranial surgery such as electrode placement for deep brain stimulation (DBS) typically involves drilling a hole in the cranium using a specialized drill called a perforator, the perforator having an associated elongated perforator bit. The cranial perforator has a clutch that causes its sharp bit to engage (rotate) when there is resistance to forward thrust and to stop rotating once penetration past the internal wall of the skull is achieved, preventing the drill from damaging the brain once the craniotomy hole has been made.
An unwanted consequence of the halting of rotation of the perforator is that the bit may become jammed in the hole that it has created, and may be difficult to remove. A surgical technique for preventing jamming of the perforator is to apply slight conical rotation to the perforator during drilling. The hole that is created while using this technique is slightly conically shaped instead of being cylindrical but still allows good attachment of the housing of the electrode holder.
Poor surgical technique when applying conical motion during perforator usage could lead to poor outcome. Too large of a conical motion could cause the hole to be larger than desired. Too small of a conical motion could cause the hole to be too cylindrical and therefore not effectively prevent jamming of the bit. Uneven conical motion could lead to an oddly shaped hole that does not hold the electrode housing well.
According to some implementations, a surgical robot system is configured for surgery on an anatomical feature of a patient, and includes a surgical robot, a robot arm connected to such surgical robot, and an end-effector connected to the robot arm.
According to some embodiments of inventive concepts, a system includes a processor circuit and a memory coupled to the processor circuit. The memory includes machine-readable instructions configured to cause the processor circuit to determine, based on a first image volume comprising an anatomical feature of a patient, a registration fixture that is fixed with respect to the anatomical feature of the patient, and a first plurality of fiducial markers that are fixed with respect to the registration fixture, determine, for each fiducial marker of the first plurality of fiducial markers, a position of the fiducial marker relative to the image volume. The machine-readable instructions are further configured to cause the processor circuit to determine, based on the determined positions of the first plurality of fiducial markers, a position and orientation of the registration fixture with respect to the anatomical feature. The machine-readable instructions are further configured to cause the processor circuit to, based on a data frame from a tracking system comprising a second plurality of tracking markers that are fixed with respect to the registration fixture, determine, for each tracking marker of the second plurality of tracking markers, a position of the tracking marker. The machine-readable instructions are further configured to cause the processor circuit to determine, based on the determined positions of the second plurality of tracking markers, a position and orientation of the registration fixture with respect to a robot arm of a surgical robot. The machine-readable instructions are further configured to cause the processor circuit to determine, based on the determined position and orientation of the registration fixture with respect to the anatomical feature and the determined position and orientation of the registration fixture with respect to the robot arm, a position and orientation of the anatomical feature with respect to the robot arm. The machine-readable instructions are further configured to cause the processor circuit to control the robot arm based on the determined position and orientation of the anatomical feature with respect to the robot arm.
According to some other embodiments of inventive concepts, a computer-implemented method is disclosed. The computer-implemented method includes, based on a first image volume comprising an anatomical feature of a patient, a registration fixture that is fixed with respect to the anatomical feature of the patient, and a first plurality of fiducial markers that are fixed with respect to the registration fixture, determining, for each fiducial marker of the first plurality of fiducial markers, a position of the fiducial marker. The computer-implemented method further includes determining, based on the determined positions of the first plurality of fiducial markers, a position and orientation of the registration fixture with respect to the anatomical feature. The computer-implemented method further includes, based on a tracking data frame comprising a second plurality of tracking markers that are fixed with respect to the registration fixture, determining, for each tracking marker of the second plurality of tracking markers, a position of the tracking marker. The computer-implemented method further includes determining, based on the determined positions of the second plurality of tracking markers, a position and orientation of the registration fixture with respect to a robot arm of a surgical robot. The computer-implemented method further includes determining, based on the determined position and orientation of the registration fixture with respect to the anatomical feature and the determined position and orientation of the registration fixture with respect to the robot arm, a position and orientation of the anatomical feature with respect to the robot arm. The computer-implemented method further includes controlling the robot arm based on the determined position and orientation of the anatomical feature with respect to the robot arm.
According to some other embodiments of inventive concepts, a surgical system is disclosed. The surgical system includes an intraoperative surgical tracking computer having a processor circuit and a memory. The memory includes machine-readable instructions configured to cause the processor circuit to provide a medical image volume defining an image space. The medical image volume includes an anatomical feature of a patient, a registration fixture that is fixed with respect to the anatomical feature of the patient, and a plurality of fiducial markers that are fixed with respect to the registration fixture. The machine-readable instructions are further configured to cause the processor circuit to, based on the medical image volume, determine, for each fiducial marker of the plurality of fiducial markers, a position of the fiducial marker with respect to the image space. The machine-readable instructions are further configured to cause the processor circuit to determine, based on the determined positions of the plurality of fiducial markers, a position and orientation of the registration fixture with respect to the anatomical feature. The machine-readable instructions are further configured to cause the processor circuit to provide a tracking data frame defining a tracking space, the tracking data frame comprising positions of a first plurality of tracked markers that are fixed with respect to the registration fixture. The machine-readable instructions are further configured to cause the processor circuit to, based on the tracking data frame, determine a position of the anatomical feature with respect to the first plurality of tracked markers in the tracking space. The surgical system further includes a surgical robot having a robot arm configured to position a surgical end-effector. The surgical robot further includes a controller connected to the robot arm. The controller is configured to perform operations including, based on the tracking data frame, determining a position of the robot arm with respect to the tracking space. The controller is configured to perform operations including determining, based on the determined position and orientation of the anatomical feature with respect to the tracking space and the determined position and orientation of the robot arm with respect to the tracking space, a position and orientation of the anatomical feature with respect to the robot arm. The controller is configured to perform operations including controlling movement of the robot arm based on the determined position and orientation of the anatomical feature with respect to the robot arm to position the surgical end-effector relative to a location on the patient to facilitate surgery on the patient.
In accordance with one possible implementation, a surgical robot system is provided for performing various operations on a patient, such as brain surgery, such brain surgery including the possibility of drilling a hole in a cranium of a patient in connection with such cranial surgery. The robot system includes certain features to address various potential drawbacks and disadvantages associated with perforation of the skull and craniotomy. The surgical system includes a surgical robot and a robot arm connected to such surgical robot. The surgical robot system further includes an end-effector in any number of suitable configurations, such end-effector being orientable so as to oppose the cranium to be operated upon, the end-effector is positioned in operative proximity to the cranium.
In such implementations, a perforator may be connected to the end-effector and the perforator is adapted or otherwise configured to be advanced or withdrawn relative to the cranium by suitable features. The perforator has an elongated perforator bit which terminates in a sharp, perforator tip. The bit has an associated bit diameter, and the perforator has a clutch operable to rotate the bit in response to detection by the surgical robot of resistance during advancement of the bit and further operable to stop bit rotation in response to detection by the surgical robot of penetration past an internal wall of the cranium.
Suitable electronic or computer implemented instructions are associated with the robot system, including, for example, a processor circuit and a memory accessible by the processor circuit and having machine-readable instructions associated therewith.
Accordingly, various operations of the surgical robot system in connection with the drilling of a hole in a cranium may be controlled or otherwise executed by suitable machine-readable instructions. For example, in certain implementations, machine-readable instructions may cause the perforator to maintain the perforator tip along a trajectory line associated with the perforation. While maintaining the perforated tip along such trajectory line, the machine-readable instructions further cause the perforator bit itself to move in a conical oscillation relative to the trajectory line during the advancement of the bit into the cranium. In other words, the elongated perforator bit is angled relative to such trajectory line so as to trace a cone whose tip corresponds substantially to the perforator tip. By virtue of such conical oscillation, a substantially circular bore is formed in the cranium through which the bit has been advanced, but such bore, by virtue of the conical oscillation, has a diameter larger than the bit diameter. The conical oscillation and associated angle are selected or determined so that the resulting bore diameter is larger than the bit diameter by an amount to reduce frictional force opposing withdrawal of the bit from the bore after penetration of the inner wall of the cranium. In this way, the risk of jamming of the perforator bit during cranium perforation is reduced.
In certain suitable implementations, the machine-readable instructions, when executed, cause the conical oscillation of the perforator to occur at an angle relative to the trajectory line ranging from about 1° to about 3°, and in certain implementations, an angle of about 2° has been found suitable.
In accordance with still other implementations, the above-described conical oscillation is associated with a perforator mode, and such perforator mode may be associated with machine-readable instructions which are user selectable through an associated user interface.
Still other implementations of a robot system capable of drilling a hole in a cranium may include a robot arm with a robot wrist and a load cell operatively associated with such robot wrist. In this implementation, the load cell senses reactive, that is, opposing force which corresponds to the perforator bit engaging the cranium. The load cell may be further configured so as to detect a reduction in such reactive force by a predetermined amount. That predetermined amount corresponds generally to the force reduction corresponding to achieving perforation, such as by penetrating the inner wall of the cranium. Upon such detection, the system may generate either a user-perceptible signal so as to warn the user or operator to cease manual advancement or an input to the system so that machine-readable instructions cease automatic advancement of the perforator and potentially withdraw such perforator away from the cranium.
While certain implementations of the system may impart the conical oscillation by movement of the robot arm or the robot wrist itself, other implementations may include a linear slide which can be angled so as to define the appropriate cone for conical oscillation, rotated, that is, orbited about a selected trajectory line, and advanced by translation of the linear slide toward the cranium being operated upon, and subsequently withdrawn upon completion or perforation of the desired procedure.
Other methods and related devices and systems, and corresponding methods and computer program products according to embodiments will be or become apparent to one with skill in the art upon review of the following drawings and detailed description. It is intended that all such devices and systems, and corresponding methods and computer program products be included within this description, be within the scope of the present disclosure, and be protected by the accompanying claims. Moreover, it is intended that all embodiments disclosed herein can be implemented separately or combined in any way and/or combination.
The accompanying drawings, which are included to provide a further understanding of the disclosure and are incorporated and constitute a part of this application, illustrate certain non-limiting embodiments of inventive concepts. In the drawings:
It is to be understood that the present disclosure is not limited in its application to the details of construction and the arrangement of components set forth in the description herein or illustrated in the drawings. The teachings of the present disclosure may be used and practiced in other embodiments and practiced or carried out in various ways. Also, it is to be understood that the phraseology and terminology used herein is for the purpose of description and should not be regarded as limiting. The use of “including,” “comprising,” or “having” and variations thereof herein is meant to encompass the items listed thereafter and equivalents thereof as well as additional items. Unless specified or limited otherwise, the terms “mounted,” “connected,” “supported,” and “coupled” and variations thereof are used broadly and encompass both direct and indirect mountings, connections, supports, and couplings. Further, “connected” and “coupled” are not restricted to physical or mechanical connections or couplings.
The following discussion is presented to enable a person skilled in the art to make and use embodiments of the present disclosure. Various modifications to the illustrated embodiments will be readily apparent to those skilled in the art, and the principles herein can be applied to other embodiments and applications without departing from embodiments of the present disclosure. Thus, the embodiments are not intended to be limited to embodiments shown, but are to be accorded the widest scope consistent with the principles and features disclosed herein. The following detailed description is to be read with reference to the figures, in which like elements in different figures have like reference numerals. The figures, which are not necessarily to scale, depict selected embodiments and are not intended to limit the scope of the embodiments. Skilled artisans will recognize the examples provided herein have many useful alternatives and fall within the scope of the embodiments.
According to some other embodiments, systems for neuronavigation registration and robotic trajectory guidance, and related methods and devices are disclosed. In some embodiments, a first image having an anatomical feature of a patient, a registration fixture that is fixed with respect to the anatomical feature of the patient, and a first plurality of fiducial markers that are fixed with respect to the registration fixture is analyzed, and a position is determined for each fiducial marker of the first plurality of fiducial markers. Next, based on the determined positions of the first plurality of fiducial markers, a position and orientation of the registration fixture with respect to the anatomical feature is determined. A data frame comprising a second plurality of tracking markers that are fixed with respect to the registration fixture is also analyzed, and a position is determined for each tracking marker of the second plurality of tracking markers. Based on the determined positions of the second plurality of tracking markers, a position and orientation of the registration fixture with respect to a robot arm of a surgical robot is determined. Based on the determined position and orientation of the registration fixture with respect to the anatomical feature and the determined position and orientation of the registration fixture with respect to the robot arm, a position and orientation of the anatomical feature with respect to the robot arm is determined, which allows the robot arm to be controlled based on the determined position and orientation of the anatomical feature with respect to the robot arm.
Advantages of this and other embodiments include the ability to combine neuronavigation and robotic trajectory alignment into one system, with support for a wide variety of different registration hardware and methods. For example, as will be described in detail below, embodiments may support both computerized tomography (CT) and fluoroscopy (fluoro) registration techniques, and may utilize frame-based and/or frameless surgical arrangements. Moreover, in many embodiments, if an initial (e.g. preoperative) registration is compromised due to movement of a registration fixture, registration of the registration fixture (and of the anatomical feature by extension) can be re-established intraoperatively without suspending surgery and re-capturing preoperative images.
Referring now to the drawings,
According to an alternative embodiment,
The surgical robot system 100 in the examples of
In many surgical procedures, one or more targets of surgical interest, such as targets within the brain for example, are localized to an external reference frame. For example, stereotactic neurosurgery may use an externally mounted stereotactic frame that facilitates patient localization and implant insertion via a frame mounted arc. Neuronavigation is used to register, e.g., map, targets within the brain based on pre-operative or intraoperative imaging. Using this pre-operative or intraoperative imaging, links and associations can be made between the imaging and the actual anatomical structures in a surgical environment, and these links and associations can be utilized by robotic trajectory systems during surgery.
According to some embodiments, various software and hardware elements may be combined to create a system that can be used to plan, register, place and verify the location of an instrument or implant in the brain. These systems may integrate a surgical robot, such as the surgical robot 102 of
The robot 102 may be positioned near or next to patient 210, and it will be appreciated that the robot 102 can be positioned at any suitable location near the patient 210 depending on the area of the patient 210 undergoing the operation. The camera 200 may be separated from the surgical robot system 100 and positioned near or next to patient 210 as well, in any suitable position that allows the camera 200 to have a direct visual line of sight to the surgical field 208. In the configuration shown, the surgeon 120 may be positioned across from the robot 102, but is still able to manipulate the end-effector 112 and the display 110. A surgical assistant 126 may be positioned across from the surgeon 120 again with access to both the end-effector 112 and the display 110. If desired, the locations of the surgeon 120 and the assistant 126 may be reversed. The traditional areas for the anesthesiologist 122 and the nurse or scrub tech 124 may remain unimpeded by the locations of the robot 102 and camera 200.
With respect to the other components of the robot 102, the display 110 can be attached to the surgical robot 102 and in other embodiments, the display 110 can be detached from surgical robot 102, either within a surgical room with the surgical robot 102, or in a remote location. The end-effector 112 may be coupled to the robot arm 104 and controlled by at least one motor. In some embodiments, end-effector 112 can comprise a guide tube 114, which is able to receive and orient a surgical instrument 108 used to perform surgery on the patient 210. As used herein, the term “end-effector” is used interchangeably with the terms “end-effectuator” and “effectuator element.” Although generally shown with a guide tube 114, it will be appreciated that the end-effector 112 may be replaced with any suitable instrumentation suitable for use in surgery. In some embodiments, end-effector 112 can comprise any known structure for effecting the movement of the surgical instrument 108 in a desired manner.
The surgical robot 102 is able to control the translation and orientation of the end-effector 112. The robot 102 is able to move end-effector 112 along x-, y-, and z-axes, for example. The end-effector 112 can be configured for selective rotation about one or more of the x-, y-, and z-axis such that one or more of the Euler Angles (e.g., roll, pitch, and/or yaw) associated with end-effector 112 can be selectively controlled. In some embodiments, selective control of the translation and orientation of end-effector 112 can permit performance of medical procedures with significantly improved accuracy compared to conventional robots that use, for example, a six degree of freedom robot arm comprising only rotational axes. For example, the surgical robot system 100 may be used to operate on patient 210, and robot arm 104 can be positioned above the body of patient 210, with end-effector 112 selectively angled relative to the z-axis toward the body of patient 210.
In some embodiments, the position of the surgical instrument 108 can be dynamically updated so that surgical robot 102 can be aware of the location of the surgical instrument 108 at all times during the procedure. Consequently, in some embodiments, surgical robot 102 can move the surgical instrument 108 to the desired position quickly without any further assistance from a physician (unless the physician so desires). In some further embodiments, surgical robot 102 can be configured to correct the path of the surgical instrument 108 if the surgical instrument 108 strays from the selected, preplanned trajectory. In some embodiments, surgical robot 102 can be configured to permit stoppage, modification, and/or manual control of the movement of end-effector 112 and/or the surgical instrument 108. Thus, in use, in some embodiments, a physician or other user can operate the system 100, and has the option to stop, modify, or manually control the autonomous movement of end-effector 112 and/or the surgical instrument 108. Further details of surgical robot system 100 including the control and movement of a surgical instrument 108 by surgical robot 102 can be found in co-pending U.S. Patent Publication No. 2013/0345718, which is incorporated herein by reference in its entirety.
As will be described in greater detail below, the surgical robot system 100 can comprise one or more tracking markers configured to track the movement of robot arm 104, end-effector 112, patient 210, and/or the surgical instrument 108 in three dimensions. In some embodiments, a plurality of tracking markers can be mounted (or otherwise secured) thereon to an outer surface of the robot 102, such as, for example and without limitation, on base 106 of robot 102, on robot arm 104, and/or on the end-effector 112. In some embodiments, such as the embodiment of
In some embodiments, pre-operative imaging may be used to identify the anatomy to be targeted in the procedure. If desired by the surgeon the planning package will allow for the definition of a reformatted coordinate system. This reformatted coordinate system will have coordinate axes anchored to specific anatomical landmarks, such as the anterior commissure (AC) and posterior commissure (PC) for neurosurgery procedures. In some embodiments, multiple pre-operative exam images (e.g., CT or magnetic resonance (MR) images) may be co-registered such that it is possible to transform coordinates of any given point on the anatomy to the corresponding point on all other pre-operative exam images.
As used herein, registration is the process of determining the coordinate transformations from one coordinate system to another. For example, in the co-registration of preoperative images, co-registering a CT scan to an MR scan means that it is possible to transform the coordinates of an anatomical point from the CT scan to the corresponding anatomical location in the MR scan. It may also be advantageous to register at least one exam image coordinate system to the coordinate system of a common registration fixture, such as a dynamic reference base (DRB), which may allow the camera 200 to keep track of the position of the patient in the camera space in real-time so that any intraoperative movement of an anatomical point on the patient in the room can be detected by the robot system 100 and accounted for by compensatory movement of the surgical robot 102.
The operations 300 may further include receiving a tracking data frame from an intraoperative tracking device comprising a plurality of tracking cameras at a second time that is later than the first time (Block 308). The tracking frame includes positions of a plurality of tracking markers that are fixed with respect to the registration fixture (FRA) and a plurality of tracking markers that are fixed with respect to the robot. The operations 300 further include determining, for based on the positions of tracking markers of the registration fixture, a position and orientation of the anatomical feature with respect to the tracking cameras (Block 310). The operations 300 further include determining, based on the determined positions of the plurality of tracking markers on the robot, a position and orientation of the robot arm of a surgical robot with respect to the tracking cameras (Block 312).
The operations 300 further include determining, based on the determined position and orientation of the anatomical feature with respect to the tracking cameras and the determined position and orientation of the robot arm with respect to the tracking cameras, a position and orientation of the anatomical feature with respect to the robot arm (Block 314). The operations 300 further include controlling movement of the robot arm with respect to the anatomical feature, e.g., along and/or rotationally about one or more defined axis, based on the determined position and orientation of the anatomical feature with respect to the robot arm (Block 316).
It should be understood that these and other features may be used and combined in different ways to achieve registration of image space, i.e., coordinates from image volume, into tracking space, i.e., coordinates for use by the surgical robot in real-time. As will be discussed in detail below, these features may include fiducial-based registration such as stereotactic frames with CT localizer, preoperative CT or MRI registered using intraoperative fluoroscopy, calibrated scanner registration where any acquired scan's coordinates are pre-calibrated relative to the tracking space, and/or surface registration using a tracked probe, for example.
In one example,
As shown by
As shown by
Once the patient is positioned, the fluoro fixture 644 is attached the fluoro unit's x-ray collecting image intensifier (not shown) and secured by tightening clamping feet 632. The fluoro fixture 644 contains fiducial markers (e.g., metal spheres laid out across two planes in this example, not shown) that are visible on 2D fluoro images captured by the fluoro image capture device and can be used to calculate the location of the x-ray source relative to the image intensifier, which is typically about 1 meter away contralateral to the patient, using a standard pinhole camera model. Detection of the metal spheres in the fluoro image captured by the fluoro image capture device also enables the software to de-warp the fluoro image (i.e., to remove pincushion and s-distortion). Additionally, the fluoro fixture 644 contains 3 or more tracking markers 646 for determining the location and orientation of the fluoro fixture 644 in tracking space. In some embodiments, software can project vectors through a CT image volume, based on a previously captured CT image, to generate synthetic images based on contrast levels in the CT image that appear similar to the actual fluoro images (i.e., digitally reconstructed radiographs (DRRs)). By iterating through theoretical positions of the fluoro beam until the DRRs match the actual fluoro shots, a match can be found between fluoro image and DRR in two or more perspectives, and based on this match, the location of the patient's head 628 relative to the x-ray source and detector is calculated. Because the tracking markers 646 on the fluoro fixture 644 track the position of the image intensifier and the position of the x-ray source relative to the image intensifier is calculated from metal fiducials on the fluoro fixture 644 projected on 2D images, the position of the x-ray source and detector in tracking space are known and the system is able to achieve image-to-tracking registration.
As shown by
For example, in one embodiment, a first fluoro image taken from a first fluoro perspective can be compared to a first DRR constructed from a first perspective through a CT image volume, and a second fluoro image taken from a second fluoro perspective can be compared to a second DRR constructed from a second perspective through the same CT image volume. Based on the comparisons, it may be determined that the first DRR is substantially equivalent to the first fluoro image with respect to the projected view of the anatomical feature, and that the second DRR is substantially equivalent to the second fluoro image with respect to the projected view of the anatomical feature. Equivalency confirms that the position and orientation of the x-ray path from emitter to collector on the actual fluoro machine as tracked in camera space matches the position and orientation of the x-ray path from emitter to collector as specified when generating the DRRs in CT space, and therefore registration of tracking space to CT space is achieved.
Another registration method for an anatomical feature of a patient, e.g., a patient's head, may be to use a surface contour map of the anatomical feature, according to some embodiments. A surface contour map may be constructed using a navigated or tracked probe, or other measuring or sensing device, such as a laser pointer, 3D camera, etc. For example, a surgeon may drag or sequentially touch points on the surface of the head with the navigated probe to capture the surface across unique protrusions, such as zygomatic bones, superciliary arches, bridge of nose, eyebrows, etc. The system then compares the resulting surface contours to contours detected from the CT and/or MR images, seeking the location and orientation of contour that provides the closest match. To account for movement of the patient and to ensure that all contour points are taken relative to the same anatomical feature, each contour point is related to tracking markers on a DRB on the patient at the time it is recorded. Since the location of the contour map is known in tracking space from the tracked probe and tracked DRB, tracking-to-image registration is obtained once the corresponding contour is found in image space.
One use for the embodiments described herein is to plan trajectories and to control a robot to move into a desired trajectory, after which the surgeon will place implants such as electrodes through a guide tube held by the robot. Additional functionalities include exporting coordinates used with existing stereotactic frames, such as a Leksell frame, which uses five coordinates: X, Y, Z, Ring Angle and Arc Angle. These five coordinates are established using the target and trajectory identified in the planning stage relative to the image space and knowing the position and orientation of the ring and arc relative to the stereotactic frame base or other registration fixture.
As shown in
Following the insertion of implants or instrumentation using the robot or ring and arc fixture, these and other embodiments may allow for implant locations to be verified using intraoperative imaging. Placement accuracy of the instrument or implant relative to the planned trajectory can be qualitatively and/or quantitatively shown to the user. One option for comparing planned to placed position is to merge a postoperative verification CT image to any of the preoperative images. Once pre- and post-operative images are merged and plan is shown overlaid, the shadow of the implant on postop CT can be compared to the plan to assess accuracy of placement. Detection of the shadow artifact on post-op CT can be performed automatically through image processing and the offset displayed numerically in terms of millimeters offset at the tip and entry and angular offset along the path. This option does not require any fiducials to be present in the verification image since image-to-image registration is performed based on bony anatomical contours.
A second option for comparing planned position to the final placement would utilize intraoperative fluoro with or without an attached fluoro fixture. Two out-of-plane fluoro images will be taken and these fluoro images will be matched to DRRs generated from pre-operative CT or MR as described above for registration. Unlike some of the registration methods described above, however, it may be less important for the fluoro images to be tracked because the key information is where the electrode is located relative to the anatomy in the fluoro image. The linear or slightly curved shadow of the electrode would be found on a fluoro image, and once the DRR corresponding to that fluoro shot is found, this shadow can be replicated in the CT image volume as a plane or sheet that is oriented in and out of the ray direction of the fluoro image and DRR. That is, the system may not know how deep in or out of the fluoro image plane the electrode lies on a given shot, but can calculate the plane or sheet of possible locations and represent this plane or sheet on the 3D volume. In a second fluoro view, a different plane or sheet can be determined and overlaid on the 3D image. Where these two planes or sheets intersect on the 3D image is the detected path of the electrode. The system can represent this detected path as a graphic on the 3D image volume and allow the user to reslice the image volume to display this path and the planned path from whatever perspective is desired, also allowing automatic or manual calculation of the deviation from planned to placed position of the electrode. Tracking the fluoro fixture is unnecessary but may be done to help de-warp the fluoro images and calculate the location of the x-ray emitter to improve accuracy of DRR calculation, the rate of convergence when iterating to find matching DRR and fluoro shots, and placement of sheets/planes representing the electrode on the 3D scan.
In this and other examples, it is desirable to maintain navigation integrity, i.e., to ensure that the registration and tracking remain accurate throughout the procedure. Two primary methods to establish and maintain navigation integrity include: tracking the position of a surveillance marker relative to the markers on the DRB, and checking landmarks within the images. In the first method, should this position change due to, for example, the DRB being bumped, then the system may alert the user of a possible loss of navigation integrity. In the second method, if a landmark check shows that the anatomy represented in the displayed slices on screen does not match the anatomy at which the tip of the probe points, then the surgeon will also become aware that there is a loss of navigation integrity. In either method, if using the registration method of CT localizer and frame reference array (FRA), the surgeon has the option to re-attach the FRA, which mounts in only one possible way to the frame base, and to restore tracking-to-image registration based on the FRA tracking markers and the stored fiducials from the CT localizer 536. This registration can then be transferred or related to tracking markers on a repositioned DRB. Once registration is transferred the FRA can be removed if desired.
Referring now to
End-effector 112 is suitably configured to permit a plurality of surgical tools 129 to be selectively connectable to end-effector 112. Thus, for example, a stylet 113 (
With reference to the previous discussion of robot surgical system 100, a processor circuit, as well as memory accessible by such processor circuit, includes various subroutines and other machine-readable instructions configured to cause, when executed, end-effector 112 to move, such as by GPS movement, relative to the anatomical feature, at predetermined stages of associated surgical operations, whether pre-operative, intra-operative or post-operative.
End-effector 112 includes various components and features to either prevent or permit end-effector movement depending on whether and which tools 129, if any, are connected to end-effector 112. Referring more particularly to
Another feature of the end-effector 112 is a tool stop 121 located on distal surface 123 of end-effector 112, that is, the surface generally opposing the patient. Tool stop 121 has a stop mechanism 125 and a sensor 127 operatively associated therewith, as seen with reference to
Another implementation of a sensor 127 for detecting engaged or disengaged tool stop mechanism 125 could comprise a single magnet behind the housing (not shown) and two Hall Effect sensors located where magnets 131 are shown in the preferred embodiment. In such a configuration, monopolar Hall Effect sensors are suitable and would be configured so that Sensor 1 detects a signal when the magnet is in proximity due to the locking mechanism being disengaged, while Sensor 2 detects a signal when the same magnet is in proximity due to the locking mechanism being engaged. Neither sensor would detect a signal when the magnet is between positions or out of proximity to either sensor. Although a configuration could be conceived in which a sensor is active for engaged position and inactive for disengaged position, a configuration with three signals indicating engaged, disengaged, or transitional is preferred to ensure correct behavior in case of power failure.
End-effector 112, tool stop 121, and tool-insert locking mechanism 117 each have co-axially aligned bores or apertures such that any selected one of the plurality of surgical tools 129 may be received through such bores and apertures. In this implementation end-effector has a bore 133 and tool stop 121 and tool-insert locking mechanism 117 have respective apertures 135 and 137. Stop mechanism 125 includes a ring 139 axially aligned with bore 133 and aperture 135 of tool stop 121. Ring 139 is selectively, manually rotatable in the directions indicated by arrow A (
In one possible implementation, the selective rotation of ring 139 includes features which enable ring 139 to be locked in either the disengaged or engaged position. So, for example, as illustrated, a detent mechanism 141 is located on and mounted to ring 139 in any suitable way to lock ring 139 against certain rotational movement out of a predetermined position, in this case, such position being when stop mechanism 125 is in the engaged position. Although various forms of detent mechanism are contemplated herein, one suitable arrangement has a manually accessible head extending circumferentially outwardly from ring 139 and having a male protrusion (not shown) spring-loaded axially inwardly to engage a corresponding female detent portion (not shown). Detent mechanism 141, as such, is manually actuatable to unlock ring 139 from its engaged position to permit ring 139 to be manually rotated to cause stop mechanism 125 to move from the engaged position (
Tool stop 121 includes a lever arm 143 pivotally mounted adjacent aperture 135 of tool stop 121 so end of lever arm 143 selectively pivots in the directions indicated by arrow B (
Lever arm 143, in this implementation, is not only pivotally mounted adjacent aperture 135, but also pivots in parallel with a distal plane defined at a distal-most point of distal surface 123 of end-effector 112. In this manner, any one of the surgical tools 129, which is attempted to be inserted through bore 133 and aperture 135, is stopped from being inserted past the distal plane in which lever arm 143 rotates to close aperture 135.
Turning now to tool-insert locking mechanism 117 (
Rotatable flange 147 has, in this implementation, a grip 173 to facilitate manual rotation between an open and closed position as shown in
Tongues 151 described as being associated with tools 129 may either be directly connected to such tools 129, and/or tongues 151 may be located on and mounted to the above-mentioned adapter 155, such as that shown in
Adapter 155 has an outer perimeter 159 which, in this implementation, is sized to oppose an inner perimeter 161 of rotatable flange 147. Adapter 155 extends between proximal and distal ends 163, 165, respectively and has an adapter bore 167 extending between ends 163, 165. Adapter bore 167 is sized to receive at least one of the plurality of surgical tools 129, and similarly, the distance between proximal and distal ends 163, 165 is selected so that at least one of tools 129 is secured to end-effector 112 at the predetermined, appropriate height for the surgical procedure associated with such tool received in adapter bore 167.
In one possible implementation, system 100 includes multiple ones of adapter 155, configured to be interchangeable inserts 169 having substantially the same, predetermined outer perimeters 159 to be received within inner perimeter 161 of rotatable flange 147. Still further in such implementation, the interchangeable inserts 169 have bores of different, respective diameters, which bores may be selected to receive corresponding ones of the tools 129 therein. Bores 167 may comprise cylindrical bushings having inner diameters common to multiple surgical tools 129. One possible set of diameters for bores 167 may be 12, 15, and 17 millimeters, suitable for multiple robotic surgery operations, such as those identified in this disclosure.
In the illustrated implementation, inner perimeter 161 of rotatable flange 147 and outer perimeter 159 of adapter 155 are circular, having central, aligned axes and corresponding radii. Slots 149 of rotatable flange 147 extend radially outwardly from the central axis of rotatable flange 147 in the illustrated implementation, whereas tongues 151 of adapter 155 extend radially outwardly from adapter 155.
In still other implementations, end-effector 112 may be equipped with at least one illumination element 171 (
The operation and associated features of end-effector 112 are readily apparent from the foregoing description. Tool stop 121 is rotatable, selectively lockable, and movable between engaged and disengaged positions, and a sensor prevents movement of end-effector 112 when in such disengaged position, due to the potential presence of a tool which may not be advisably moved during such disengaged position. Tool-insert locking mechanism 117 is likewise rotatable between open and closed positions to receive one of a plurality of interchangeable inserts 169 and tongues 151 of such inserts, wherein selected tools 129 may be received in such inserts 169; alternately, tongues 151 may be otherwise associated with tools 129, such as by having tongues 151 directly connected to such tools 129, which tongue-equipped tools likewise may be received in corresponding slots 149 of tool-insert locking mechanism 117. Tool-insert locking mechanism 117 may be rotated from its open position in which tongues 151 have been received in slots 149, to secure associated adapters 155 and/or tools 129 so that they are at appropriate, respective heights, angles of orientation, and rotational positions relative to the anatomical feature of the patient.
For those implementations with multiple adapters 155, the dimensions of such adapters 155, including bore diameters, height, and other suitable dimensions, are selected so that a single or a minimized number of end-effectors 112 can be used for a multiplicity of surgical tools 129. Adapters 155, such as those in the form of interchangeable inserts 169 or cylindrical bushings, may facilitate connecting an expanded set of surgical tools 129 to the end-effector 112, and thus likewise facilitate a corresponding expanded set of associated surgical features using the same end-effector 112.
One of the surgical tools 129 suitable for use with end-effector 112 is a perforator 222 connectable to end-effector 112. Perforator 222 is shown schematically in this disclosure, for purposes of illustrating its conical oscillations and other related operations and features. Accordingly, it will be appreciated that the dimensions of the perforator 222 are not to scale, and that the diameter of perforator 222, as well as the perforator bit and perforator tip discussed herein are often larger than as illustrated in
End-effector 112, in certain implementations, may comprise a robot wrist 226 or a similar arrangement of moveable components so that the perforator 222 is connectable to end-effector 112 and configured to be advanced or withdrawn along a trajectory line L relative to the cranium of patient's head 128. Perforator 222 has an elongated perforator bit 224 terminating in a sharp perforator tip 228. Perforator bit 224 has a corresponding bit diameter as well as an internal mechanical clutch (not shown) operable to selectively engage or disengage rotation of bit 224 so as to drill a bore in a cranium for contemplated surgical procedures, including any number of craniotomies, such as DBS electrode placement and other associated operations associated with cranial surgery. The clutch mechanism is spring-loaded longitudinally, so that the spring forces interfacing portions apart from each other when there is no forward force present opposing the bit. With the clutch mechanism separated, although the inner shaft of the drill continues to spin, the bit is not engaged and does not spin. With forward thrusting longitudinal force, as the spring is overcome, the portions of the clutch mechanism are forced together, allowing the rotating shaft to engage the bit and cause the bit to rotate with the shaft.
In one suitable mode of operation, clutch engages and rotates bit 224 as interfacing portions of the clutch are forced together by resistance or similar opposing or reactive force during advancement of bit 224, and clutch disengages rotation when interfacing portions move apart after the leading edge of the bit penetrates past an internal wall of the cranium, such penetration associated with insufficient force to keep the portions of the clutch engaged.
Certain operations of perforator 222 may be performed manually, such as manual advancement or withdrawal of perforator bit 224 relative to the cranium. This and other operations may be performed by various computer implementations, including a processor circuit associated with such computerized implementation, a memory accessible by the processor circuit and comprising machine-readable instructions for performing various steps associated with perforator 222.
In one possible implementation, the machine-readable instructions, when executed, cause perforator 222 not only to maintain perforator tip 228 along the trajectory line L during advancement of bit 224 toward the cranium, but they further cause the perforator bit to move in a conical oscillation relative to trajectory line L.
As a result of moving perforator bit 224 in a conical oscillation while also advancing it through the cranium, the bore formed in the cranium is generally circular and has a diameter larger than the bore diameter which would have been formed without such conical oscillation movement during advancement of the perforator tip. As such, a bore is formed in the cranium having a diameter not only larger than the bit diameter, but the oscillation is selected so that the resulting bore of larger diameter reduces frictional force which might otherwise oppose withdrawal of perforator bit 224 from the bore formed in the cranium after penetration of the inner wall of such cranium. Such frictional force is otherwise associated with jamming of the perforator bit 224 in the cranium and therefore the larger bore accomplished by conical oscillation reduces the risk of such jamming.
In certain implementations, orienting the perforator bit at an angle B relative to trajectory line L ranging from about 1° to about 3° has been found suitable, and in certain other implementations, an angle β of about 2° relative to trajectory line L has been found suitable.
The above-described conical oscillation movement may be initiated, controlled, or otherwise implemented in association with either manual or automatic steps in any number of ways. For example, oscillation may be imparted by the robotic system 100 including a suitable user interface and machine-readable instructions corresponding to a perforator mode. As such, the conical oscillation may be initiated, caused or controlled by user selection of such perforator mode through the user interface. In other possible implementations, end-effector 112 in the form of robot wrist 226 may be advanced by manually moving robot arm 104 or other components associated with advancement of end-effector 112 and similarly, withdrawing up trajectory line L after perforation of the cranium may be performed manually.
In still other implementations, a load cell 232 may be operatively connected to robot wrist 226. Load cell 232 is configured to sense reactive force corresponding to perforator bit 224 engaging the cranium. Load cell 232 likewise is able to detect a reduction in such reactive force by a predetermined amount. Such predetermined amount is selected or corresponds to the drop-off of reactive force corresponding to completion of perforation of the cranium. As such, the system 100 may include further machine-readable instructions responsive to the load cell detecting such reduction in reactive force by the predetermined amount. One set of instructions in response to detection of reduction in the reactive force may result in generation of a user perceptible signal or alarm, especially useful if the perforator 222 is being advanced manually, so that the user may cease manual advancement upon receiving the signal generated by system 100.
The perforator mode of system 100 may include more automated control of perforator 222, such that, upon load cell 232 detecting the reduction in reactive force corresponding to completing perforation, the automatic advancement accomplished by system 100 of perforator 222 is automatically ceased. Control of advancement and withdraw of the perforator may be further automated so that, upon detection by the load cell of the requisite reduction in reactive force, not only is advancement ceased, but the robot arm, wrist, or perforator are withdrawn along trajectory line L thereafter.
In still another possible variation of control of perforator 222 by suitable machine-readable instructions, robot wrist 226 may be located so as to be accessible to the user and load cell 232 is configured to sense manual application of forward and rearward force to either the end-effector 112, robot arm 102, or robot wrist 226. Such manual force may be a tap forward or a tap back. In response to detecting such force, machine-readable instructions may cause perforator 222 to move down trajectory line L in response to sensing a forward tap and may cause the perforator 222 to be moved up the trajectory line L in response to sensing a rearward tap.
In view of the foregoing, system 100 may, in certain implementations include suitable instructions to inter-relate signals from load cell 232, corresponding to the presence and amount of reactive force experienced by perforator bit 224 with features of a clutch or motor controller 230 with electronic signal inputs related to selective rotation of perforator bit 224. In this way, system 100 may control not only advancement or withdrawal of perforator 222 by means of load cell 232, but may also interact with or replace clutch 230 to start, stop or vary speed of rotation of perforator bit 224. Such interactions may be a function of the amount of reactive force sensed by load cell 232, including cessation of such rotation upon fall-off of reactive force sensed by the load cell 232 by one or more predetermined amounts.
Although the implementations illustrated and described above with reference to
Linear slide 234 includes inner and outer cylindrical assemblies, which may be oriented concentrically so that each cylinder's central axis corresponds to the directions of advancement and withdrawal along trajectory line L. A pair of tracks 236 extends vertically at locations relative to trajectory line L and is defined in circular members 238 approximately 180 degrees from each other. The inner cylindrical assembly includes a ring 240 with tongues slideably received within grooves 236. Radially inwardly from ring 240, a bracket 244 is connected to a guide tube 248 within which perforator 222 is suitably connected. A rotary bearing 242 rotatably connects bracket 244 to ring 240. The movement vertically of ring 240 relative to grooves 236 corresponds to advancement or withdrawal of perforator 222, rotary movement of rotary bearing 242 in a circular fashion corresponds to conical oscillation, as it allows bracket 244 to spin within ring 240 while swivel perforator bit 224 is held at an angle to bracket 244.
Bracket 244 includes offset slots 246 at upper and lower ends of bracket 244. Offset slots 246 provide a track within which cylindrical bumpouts on guide tube 248 move, permitting perforator tip 228 to be maintained at adjustable positions near or on trajectory line L, while also allowing perforator tail end to be positioned at adjustable offsets near or on trajectory line L that may be different than offsets of perforator tip 228. To that end, the radius of the cone associated with the conical oscillation may vary depending on the location of guide tube 248 within bracket 244, and location of perforator bit 224 and perforator tail end relative to line L.
The operation of linear slide 234 is apparent from the foregoing description. The appropriate angle β of perforator bit 224 may be set by manual or automatic movement of guide tube 248 within offset slots 246. Suitable moveable connections and associated motors are actuatable in response to programmable logic controllers and associated machine-readable instructions to impart rotation associated with the conical oscillation of perforator bit 224 by rotary bearing 242 being rotated within ring 240 by suitable instructions and associated rotation means. As perforator bit 224 is orbited at its angle β relative to trajectory line L, perforator tip 228 is maintained along trajectory line L and advanced by relative movement of ring 240 within grooves 236 near slide 234.
Alternately, it will be appreciated that linear slide 234 may be adjusted so that guide tube 248 is coaxial with trajectory line L. Such coaxial alignment would occur when guide tube 248 is moved to points within offsets 246 corresponding to such axial alignment. In such axial alignment, both rotation and advancement of perforator bit 224 may occur without conical oscillation associated therewith. During operations of linear slide 234, robot wrist 226 and robot arm 104 may remain stationary during all or part of advancement or withdrawal of perforator bit 224 relative to the cranium and the bore being formed therein.
Operations of the implementations disclosed with reference to
A conical oscillation will be imparted to the perforator bit 224 by suitable computer control during advancement into the cranium by orbiting the perforator bit 224 at a predetermined radial distance from trajectory line L while maintaining the perforator tip 228 aligned with trajectory line L during such advancement. The resulting conical oscillation, that is, orbiting of the perforator bit and maintaining the perforator tip aligned with its trajectory lines will define an angle relative to such trajectory line and such angle has been selected so that the bore formed upon perforation has a greater diameter than the bit diameter itself. The increased diameter is selected to be sufficient to reduce frictional force opposing withdraw of the bit from the bore.
The above-described orbiting of the perforator bit and maintenance of perforator tip in alignment with the trajectory line may be selectively combined with any number of related operations of robot 102 and its system 100, as well as manual operations associated with cranial procedures. In one possible workflow, while in perforator mode, the robot generates the continuously cycling conical motion as described above while still allowing the operator to cause an associated end-effector 112 to advance or withdraw along the pathway through the center of the cone defined by such conical motion. As such, with robot or automatic control of the aforesaid conical motion, a surgeon operating system 100 can concentrate on causing perforator 222 to advance as desired to create the planned craniotomy, and the surgeon's operations may be similar to those associated with advancement without such conical oscillation. In this workflow, then, the complexity of the surgeon's manipulations of robot 102 is reduced by removing the need to manually oscillate the perforator bit while also advancing it.
In another possible workflow, a patient's anatomical coordinate system is registered to the coordinate system of robot 102 or tracking cameras or other related coordinate systems discussed in this application with reference to the implementations of
User activation may be used through a suitable interface to start perforator mode at which point robot 102 imparts the conical oscillation to perforator bit 224, namely, keeping perforator tip 228 located at a suitable point along the desired trajectory line L while moving more perforator bit 224 proximal points away from perforator tip 228 in a circular motion at some radius spaced from the desired trajectory line L.
Movement of end-effector 112, including components of robot wrist 226, may be effectuated by any suitable manual or automatic means. Force forward to advance end-effector 112 and perforator 222 secured thereto may be applied manually, either as an initial tap or continuously, in either event such forward thrust is sensed by a load cell and in response thereto, the end-effector 112 and robot wrist move so as to advance down the trajectory line. Suitable machine-readable instructions of software may alternately be used so that the perforator 222 is advanced down the trajectory line and feedback from the load cell 232 may be used to control such forward movement, the reduction of reactive force signaling the successful perforation of the cranium and ceasing further advanced movement in such automatic mode.
Once the cranium has been penetrated the end-effector 112 and its associated perforator 222 are moved back up the trajectory line either manually using reverse operations of those described previously or automatically through suitable machine-readable instructions.
Upon completion of the desired perforation or at any other suitable moment during the foregoing procedures, the perforator mode and its associated conical oscillation may be deactivated either in response to certain conditions as mentioned above or in response to user input.
In those procedures where the robot and its perforator 222 are being moved manually, system 100 may include a graphical display of the force sensed by load cell 232 which may serve as a useful guide to the surgeon as to when such surgeon should stop applying manual force during the perforation procedure. In those circumstances where linear slide 234 is used, rather than oscillating the entire robot arm, in certain circumstances, quicker disengagement of perforator 222 may be accomplished because withdrawal of such perforator can be accomplished by the linear slide 234 while robot arm 104 remains in its position for other related procedures.
As can be understood from the foregoing description, the hole drilled using either coordinated robot arm movement or advancement of a linear slide 234 would be conical in shape, wherein the deeper the penetration, the larger the hole radius becomes as a wider portion of the fixed conical pattern of drill bit movement cuts bone. In some applications, however, it may be desirable to drill a first hole to the depth of the cranial bone that is then expanded radially without advancing the drill deeper and damaging brain tissue. In other applications, it may be desirable to limit the amount of bone dust created while precisely fitting an implantable surgical device by using a smaller diameter cutting bit and continuously adjust the offset of the tip and trailing end of the perforator so that it cuts with a perfectly conical path at all positions longitudinally down trajectory line L. In other words, the cutting pattern at the tip would start as a sweeping circular pattern on first penetration and gradually narrow its path of travel until the tip is at or close to a fixed point at final penetration, leaving a conical cut through bone that has a radius larger than the radius of the drill bit.
To achieve an expanded hole after a first hole is completed and to cut while narrowing the path of travel during advancement, the offsets of tip and tail of the perforator relative to trajectory line L would be adjusted automatically or manually at or after different points during drill advancement. Adjustment of the cutting path may involve adjustment of the oscillation imparted to perforator 222 by either robot wrist 226 or linear slide 234. Such adjustment would be a function of where perforator tip 228 and perforator tail are positioned relative to trajectory line L, as described previously with reference to
In certain implementations, then, one or more sensors, such as Hall Effect sensors, optical tracking, LVDT (linear variable differential transformer), resistive wiper, and the like may be used to continuously or periodically monitor location of perforator tip 228 and perforator tail relative to the location of linear slide 234 within grooves 236 (
In other implementations, tracking of the robot arm through similar sensors may be used to continuously or periodically monitor location of robot arm relative to cranium. Location of perforator tip 228 determined by the foregoing sensors will allow suitable instructions of system 100 to calculate and apply the necessary robotic movement to create oscillation that is conical or cylindrical with appropriate oscillation radius while appropriately locating perforator tip 228 and tail along the desired trajectory and in turn angling the balance of perforator bit 224 proximally to achieve a perforation bore of the desired diameter to avoid potential jamming.
In the above-description of various embodiments of present inventive concepts, it is to be understood that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of present inventive concepts. Unless otherwise defined, all terms (including technical and scientific terms) used herein have the same meaning as commonly understood by one of ordinary skill in the art to which present inventive concepts belong. It will be further understood that terms, such as those defined in commonly used dictionaries, should be interpreted as having a meaning that is consistent with their meaning in the context of this specification and the relevant art and will not be interpreted in an idealized or overly formal sense unless expressly so defined herein.
When an element is referred to as being “connected”, “coupled”, “responsive”, or variants thereof to another element, it can be directly connected, coupled, or responsive to the other element or intervening elements may be present. In contrast, when an element is referred to as being “directly connected”, “directly coupled”, “directly responsive”, or variants thereof to another element, there are no intervening elements present. Like numbers refer to like elements throughout. Furthermore, “coupled”, “connected”, “responsive”, or variants thereof as used herein may include wirelessly coupled, connected, or responsive. As used herein, the singular forms “a”, “an” and “the” are intended to include the plural forms as well, unless the context clearly indicates otherwise. Well-known functions or constructions may not be described in detail for brevity and/or clarity. The term “and/or” includes any and all combinations of one or more of the associated listed items.
It will be understood that although the terms first, second, third, etc. may be used herein to describe various elements/operations, these elements/operations should not be limited by these terms. These terms are only used to distinguish one element/operation from another element/operation. Thus a first element/operation in some embodiments could be termed a second element/operation in other embodiments without departing from the teachings of present inventive concepts. The same reference numerals or the same reference designators denote the same or similar elements throughout the specification.
As used herein, the terms “comprise”, “comprising”, “comprises”, “include”, “including”, “includes”, “have”, “has”, “having”, or variants thereof are open-ended, and include one or more stated features, integers, elements, steps, components or functions but does not preclude the presence or addition of one or more other features, integers, elements, steps, components, functions or groups thereof. Furthermore, as used herein, the common abbreviation “e.g.”, which derives from the Latin phrase “exempli gratia,” may be used to introduce or specify a general example or examples of a previously mentioned item, and is not intended to be limiting of such item. The common abbreviation “i.e.”, which derives from the Latin phrase “id est,” may be used to specify a particular item from a more general recitation.
Example embodiments are described herein with reference to block diagrams and/or flowchart illustrations of computer-implemented methods, apparatus (systems and/or devices) and/or computer program products. It is understood that a block of the block diagrams and/or flowchart illustrations, and combinations of blocks in the block diagrams and/or flowchart illustrations, can be implemented by computer program instructions that are performed by one or more computer circuits. These computer program instructions may be provided to a processor circuit of a general purpose computer circuit, special purpose computer circuit, and/or other programmable data processing circuit to produce a machine, such that the instructions, which execute via the processor of the computer and/or other programmable data processing apparatus, transform and control transistors, values stored in memory locations, and other hardware components within such circuitry to implement the functions/acts specified in the block diagrams and/or flowchart block or blocks, and thereby create means (functionality) and/or structure for implementing the functions/acts specified in the block diagrams and/or flowchart block(s).
These computer program instructions may also be stored in a tangible computer-readable medium that can direct a computer or other programmable data processing apparatus to function in a particular manner, such that the instructions stored in the computer-readable medium produce an article of manufacture including instructions which implement the functions/acts specified in the block diagrams and/or flowchart block or blocks. Accordingly, embodiments of present inventive concepts may be embodied in hardware and/or in software (including firmware, resident software, micro-code, etc.) that runs on a processor such as a digital signal processor, which may collectively be referred to as “circuitry,” “a module” or variants thereof.
It should also be noted that in some alternate implementations, the functions/acts noted in the blocks may occur out of the order noted in the flowcharts. For example, two blocks shown in succession may in fact be executed substantially concurrently or the blocks may sometimes be executed in the reverse order, depending upon the functionality/acts involved. Moreover, the functionality of a given block of the flowcharts and/or block diagrams may be separated into multiple blocks and/or the functionality of two or more blocks of the flowcharts and/or block diagrams may be at least partially integrated. Finally, other blocks may be added/inserted between the blocks that are illustrated, and/or blocks/operations may be omitted without departing from the scope of inventive concepts. Moreover, although some of the diagrams include arrows on communication paths to show a primary direction of communication, it is to be understood that communication may occur in the opposite direction to the depicted arrows.
Although several embodiments of inventive concepts have been disclosed in the foregoing specification, it is understood that many modifications and other embodiments of inventive concepts will come to mind to which inventive concepts pertain, having the benefit of teachings presented in the foregoing description and associated drawings. It is thus understood that inventive concepts are not limited to the specific embodiments disclosed hereinabove, and that many modifications and other embodiments are intended to be included within the scope of the appended claims. It is further envisioned that features from one embodiment may be combined or used with the features from a different embodiment(s) described herein. Moreover, although specific terms are employed herein, as well as in the claims which follow, they are used only in a generic and descriptive sense, and not for the purposes of limiting the described inventive concepts, nor the claims which follow. The entire disclosure of each patent and patent publication cited herein is incorporated by reference herein in its entirety, as if each such patent or publication were individually incorporated by reference herein. Various features and/or potential advantages of inventive concepts are set forth in the following claims.
This application is a continuation of U.S. patent application Ser. No. 16/821,331, filed on Mar. 17, 2020 (published as U.S. Pat. Pub. No. 2020-0297358), which is a continuation-in-part of U.S. patent application Ser. No. 16/452,737, filed Jun. 26, 2019 (now U.S. Pat. No. 11,317,978), which is a continuation-in-part of U.S. patent application Ser. No. 16/361,863, filed on Mar. 22, 2019 (published as U.S. Pat. Pub. No. 2020-0297426), the entire contents of each of which are hereby incorporated herein by reference for all purposes.
| Number | Name | Date | Kind |
|---|---|---|---|
| 4150293 | Franke | Apr 1979 | A |
| 5246010 | Gazzara et al. | Sep 1993 | A |
| 5354314 | Hardy et al. | Oct 1994 | A |
| 5397323 | Taylor et al. | Mar 1995 | A |
| 5423832 | Gildenberg | Jun 1995 | A |
| 5598453 | Baba et al. | Jan 1997 | A |
| 5647373 | Paltieli | Jul 1997 | A |
| 5772594 | Barrick | Jun 1998 | A |
| 5791908 | Gillio | Aug 1998 | A |
| 5820559 | Ng et al. | Oct 1998 | A |
| 5825982 | Wright et al. | Oct 1998 | A |
| 5887121 | Funda et al. | Mar 1999 | A |
| 5911449 | Daniele et al. | Jun 1999 | A |
| 5951475 | Gueziec et al. | Sep 1999 | A |
| 5987960 | Messner et al. | Nov 1999 | A |
| 6012216 | Esteves et al. | Jan 2000 | A |
| 6031888 | Ivan et al. | Feb 2000 | A |
| 6033415 | Mittelstadt et al. | Mar 2000 | A |
| 6073512 | McCormick et al. | Jun 2000 | A |
| 6080181 | Jensen et al. | Jun 2000 | A |
| 6106511 | Jensen | Aug 2000 | A |
| 6122541 | Cosman et al. | Sep 2000 | A |
| 6144875 | Schweikard et al. | Nov 2000 | A |
| 6157853 | Blume et al. | Dec 2000 | A |
| 6167145 | Foley et al. | Dec 2000 | A |
| 6167292 | Badano et al. | Dec 2000 | A |
| 6200274 | McNeirney | Mar 2001 | B1 |
| 6201984 | Funda et al. | Mar 2001 | B1 |
| 6203196 | Meyer et al. | Mar 2001 | B1 |
| 6205411 | DiGioia, III et al. | Mar 2001 | B1 |
| 6212419 | Blume et al. | Apr 2001 | B1 |
| 6231565 | Tovey et al. | May 2001 | B1 |
| 6236875 | Bucholz et al. | May 2001 | B1 |
| 6246900 | Cosman et al. | Jun 2001 | B1 |
| 6298262 | Franck et al. | Oct 2001 | B1 |
| 6301495 | Gueziec et al. | Oct 2001 | B1 |
| 6306126 | Montezuma | Oct 2001 | B1 |
| 6312435 | Wallace et al. | Nov 2001 | B1 |
| 6314311 | Williams et al. | Nov 2001 | B1 |
| 6320929 | Von Der Haar | Nov 2001 | B1 |
| 6322567 | Mittelstadt et al. | Nov 2001 | B1 |
| 6325808 | Bernard et al. | Dec 2001 | B1 |
| 6340363 | Bolger et al. | Jan 2002 | B1 |
| 6377011 | Ben-Ur | Apr 2002 | B1 |
| 6379302 | Kessman et al. | Apr 2002 | B1 |
| 6402762 | Hunter et al. | Jun 2002 | B2 |
| 6424885 | Niemeyer et al. | Jul 2002 | B1 |
| 6447503 | Wynne et al. | Sep 2002 | B1 |
| 6451027 | Cooper et al. | Sep 2002 | B1 |
| 6477400 | Barrick | Nov 2002 | B1 |
| 6484049 | Seeley et al. | Nov 2002 | B1 |
| 6487267 | Wolter | Nov 2002 | B1 |
| 6490467 | Bucholz et al. | Dec 2002 | B1 |
| 6490475 | Seeley et al. | Dec 2002 | B1 |
| 6499488 | Hunter et al. | Dec 2002 | B1 |
| 6501981 | Schweikard et al. | Dec 2002 | B1 |
| 6507751 | Blume et al. | Jan 2003 | B2 |
| 6535756 | Simon et al. | Mar 2003 | B1 |
| 6560354 | Maurer, Jr. et al. | May 2003 | B1 |
| 6565554 | Niemeyer | May 2003 | B1 |
| 6587750 | Gerbi et al. | Jul 2003 | B2 |
| 6614453 | Suri et al. | Sep 2003 | B1 |
| 6614871 | Kobiki et al. | Sep 2003 | B1 |
| 6619840 | Rasche et al. | Sep 2003 | B2 |
| 6636757 | Jascob et al. | Oct 2003 | B1 |
| 6645196 | Nixon et al. | Nov 2003 | B1 |
| 6666579 | Jensen | Dec 2003 | B2 |
| 6669635 | Kessman et al. | Dec 2003 | B2 |
| 6701173 | Nowinski et al. | Mar 2004 | B2 |
| 6757068 | Foxlin | Jun 2004 | B2 |
| 6782287 | Grzeszczuk et al. | Aug 2004 | B2 |
| 6783524 | Anderson et al. | Aug 2004 | B2 |
| 6786896 | Madhani et al. | Sep 2004 | B1 |
| 6788018 | Blumenkranz | Sep 2004 | B1 |
| 6804581 | Wang et al. | Oct 2004 | B2 |
| 6823207 | Jensen et al. | Nov 2004 | B1 |
| 6827351 | Graziani et al. | Dec 2004 | B2 |
| 6837892 | Shoham | Jan 2005 | B2 |
| 6839612 | Sanchez et al. | Jan 2005 | B2 |
| 6840895 | Perry et al. | Jan 2005 | B2 |
| 6856826 | Seeley et al. | Feb 2005 | B2 |
| 6856827 | Seeley et al. | Feb 2005 | B2 |
| 6879880 | Nowlin et al. | Apr 2005 | B2 |
| 6892090 | Verard et al. | May 2005 | B2 |
| 6920347 | Simon et al. | Jul 2005 | B2 |
| 6922632 | Foxlin | Jul 2005 | B2 |
| 6968224 | Kessman et al. | Nov 2005 | B2 |
| 6978166 | Foley et al. | Dec 2005 | B2 |
| 6988009 | Grimm et al. | Jan 2006 | B2 |
| 6991627 | Madhani et al. | Jan 2006 | B2 |
| 6996487 | Jutras et al. | Feb 2006 | B2 |
| 6999852 | Green | Feb 2006 | B2 |
| 7007699 | Martinelli et al. | Mar 2006 | B2 |
| 7008362 | Fitzgibbon | Mar 2006 | B2 |
| 7016457 | Senzig et al. | Mar 2006 | B1 |
| 7043961 | Pandey et al. | May 2006 | B2 |
| 7062006 | Pelc et al. | Jun 2006 | B1 |
| 7063705 | Young et al. | Jun 2006 | B2 |
| 7072707 | Galloway, Jr. et al. | Jul 2006 | B2 |
| 7083615 | Peterson et al. | Aug 2006 | B2 |
| 7097640 | Wang et al. | Aug 2006 | B2 |
| 7099428 | Clinthorne et al. | Aug 2006 | B2 |
| 7108421 | Gregerson et al. | Sep 2006 | B2 |
| 7130676 | Barrick | Oct 2006 | B2 |
| 7139418 | Abovitz et al. | Nov 2006 | B2 |
| 7139601 | Bucholz et al. | Nov 2006 | B2 |
| 7155316 | Sutherland et al. | Dec 2006 | B2 |
| 7164968 | Treat et al. | Jan 2007 | B2 |
| 7167738 | Schweikard et al. | Jan 2007 | B2 |
| 7169141 | Brock et al. | Jan 2007 | B2 |
| 7172627 | Fiere et al. | Feb 2007 | B2 |
| 7194120 | Wicker et al. | Mar 2007 | B2 |
| 7197107 | Arai et al. | Mar 2007 | B2 |
| 7231014 | Levy | Jun 2007 | B2 |
| 7231063 | Naimark et al. | Jun 2007 | B2 |
| 7239940 | Wang et al. | Jul 2007 | B2 |
| 7248914 | Hastings et al. | Jul 2007 | B2 |
| 7301648 | Foxlin | Nov 2007 | B2 |
| 7302288 | Schellenberg | Nov 2007 | B1 |
| 7313430 | Urquhart et al. | Dec 2007 | B2 |
| 7318805 | Schweikard et al. | Jan 2008 | B2 |
| 7318827 | Leitner et al. | Jan 2008 | B2 |
| 7319897 | Leitner et al. | Jan 2008 | B2 |
| 7324623 | Heuscher et al. | Jan 2008 | B2 |
| 7327865 | Fu et al. | Feb 2008 | B2 |
| 7331967 | Lee et al. | Feb 2008 | B2 |
| 7333642 | Green | Feb 2008 | B2 |
| 7339341 | Oleynikov et al. | Mar 2008 | B2 |
| 7366562 | Dukesherer et al. | Apr 2008 | B2 |
| 7379790 | Toth et al. | May 2008 | B2 |
| 7386365 | Nixon | Jun 2008 | B2 |
| 7422592 | Morley et al. | Sep 2008 | B2 |
| 7435216 | Kwon et al. | Oct 2008 | B2 |
| 7440793 | Chauhan et al. | Oct 2008 | B2 |
| 7460637 | Clinthorne et al. | Dec 2008 | B2 |
| 7466303 | Yi et al. | Dec 2008 | B2 |
| 7493153 | Ahmed et al. | Feb 2009 | B2 |
| 7505617 | Fu et al. | Mar 2009 | B2 |
| 7533892 | Schena et al. | May 2009 | B2 |
| 7542791 | Mire et al. | Jun 2009 | B2 |
| 7555331 | Viswanathan | Jun 2009 | B2 |
| 7567834 | Clayton et al. | Jul 2009 | B2 |
| 7594912 | Cooper et al. | Sep 2009 | B2 |
| 7606613 | Simon et al. | Oct 2009 | B2 |
| 7607440 | Coste-Maniere et al. | Oct 2009 | B2 |
| 7623902 | Pacheco | Nov 2009 | B2 |
| 7630752 | Viswanathan | Dec 2009 | B2 |
| 7630753 | Simon et al. | Dec 2009 | B2 |
| 7643862 | Schoenefeld | Jan 2010 | B2 |
| 7660623 | Hunter et al. | Feb 2010 | B2 |
| 7661881 | Gregerson et al. | Feb 2010 | B2 |
| 7683331 | Chang | Mar 2010 | B2 |
| 7683332 | Chang | Mar 2010 | B2 |
| 7689320 | Prisco et al. | Mar 2010 | B2 |
| 7691098 | Wallace et al. | Apr 2010 | B2 |
| 7702379 | Avinash et al. | Apr 2010 | B2 |
| 7702477 | Tuemmler et al. | Apr 2010 | B2 |
| 7711083 | Heigl et al. | May 2010 | B2 |
| 7711406 | Kuhn et al. | May 2010 | B2 |
| 7720523 | Omernick et al. | May 2010 | B2 |
| 7725253 | Foxlin | May 2010 | B2 |
| 7726171 | Langlotz et al. | Jun 2010 | B2 |
| 7742801 | Neubauer et al. | Jun 2010 | B2 |
| 7751865 | Jascob et al. | Jul 2010 | B2 |
| 7760849 | Zhang | Jul 2010 | B2 |
| 7762825 | Burbank et al. | Jul 2010 | B2 |
| 7763015 | Cooper et al. | Jul 2010 | B2 |
| 7787699 | Mahesh et al. | Aug 2010 | B2 |
| 7796728 | Bergfjord | Sep 2010 | B2 |
| 7813838 | Sommer | Oct 2010 | B2 |
| 7818044 | Dukesherer et al. | Oct 2010 | B2 |
| 7819859 | Prisco et al. | Oct 2010 | B2 |
| 7824401 | Manzo et al. | Nov 2010 | B2 |
| 7831294 | Viswanathan | Nov 2010 | B2 |
| 7834484 | Sartor | Nov 2010 | B2 |
| 7835557 | Kendrick et al. | Nov 2010 | B2 |
| 7835778 | Foley et al. | Nov 2010 | B2 |
| 7835784 | Mire et al. | Nov 2010 | B2 |
| 7840253 | Tremblay et al. | Nov 2010 | B2 |
| 7840256 | Lakin et al. | Nov 2010 | B2 |
| 7843158 | Prisco | Nov 2010 | B2 |
| 7844320 | Shahidi | Nov 2010 | B2 |
| 7853305 | Simon et al. | Dec 2010 | B2 |
| 7853313 | Thompson | Dec 2010 | B2 |
| 7865269 | Prisco et al. | Jan 2011 | B2 |
| D631966 | Perloff et al. | Feb 2011 | S |
| 7879045 | Gielen et al. | Feb 2011 | B2 |
| 7881767 | Strommer et al. | Feb 2011 | B2 |
| 7881770 | Melkent et al. | Feb 2011 | B2 |
| 7886743 | Cooper et al. | Feb 2011 | B2 |
| RE42194 | Foley et al. | Mar 2011 | E |
| RE42226 | Foley et al. | Mar 2011 | E |
| 7900524 | Calloway et al. | Mar 2011 | B2 |
| 7907166 | Lamprecht et al. | Mar 2011 | B2 |
| 7909122 | Schena et al. | Mar 2011 | B2 |
| 7925653 | Saptharishi | Apr 2011 | B2 |
| 7930065 | Larkin et al. | Apr 2011 | B2 |
| 7935130 | Willliams | May 2011 | B2 |
| 7940999 | Liao et al. | May 2011 | B2 |
| 7945012 | Ye et al. | May 2011 | B2 |
| 7945021 | Shapiro et al. | May 2011 | B2 |
| 7953470 | Vetter et al. | May 2011 | B2 |
| 7954397 | Choi et al. | Jun 2011 | B2 |
| 7963913 | Devengenzo et al. | Jun 2011 | B2 |
| 7971341 | Dukesherer et al. | Jul 2011 | B2 |
| 7974674 | Hauck et al. | Jul 2011 | B2 |
| 7974677 | Mire et al. | Jul 2011 | B2 |
| 7974681 | Wallace et al. | Jul 2011 | B2 |
| 7979157 | Anvari | Jul 2011 | B2 |
| 7983733 | Viswanathan | Jul 2011 | B2 |
| 7988215 | Seibold | Aug 2011 | B2 |
| 7996110 | Lipow et al. | Aug 2011 | B2 |
| 8004121 | Sartor | Aug 2011 | B2 |
| 8004229 | Nowlin et al. | Aug 2011 | B2 |
| 8010177 | Csavoy et al. | Aug 2011 | B2 |
| 8019045 | Kato | Sep 2011 | B2 |
| 8021310 | Sanborn et al. | Sep 2011 | B2 |
| 8035685 | Jensen | Oct 2011 | B2 |
| 8046054 | Kim et al. | Oct 2011 | B2 |
| 8046057 | Clarke | Oct 2011 | B2 |
| 8052688 | Wolf, II | Nov 2011 | B2 |
| 8054184 | Cline et al. | Nov 2011 | B2 |
| 8054752 | Druke et al. | Nov 2011 | B2 |
| 8057397 | Li et al. | Nov 2011 | B2 |
| 8057407 | Martinelli et al. | Nov 2011 | B2 |
| 8062288 | Cooper et al. | Nov 2011 | B2 |
| 8062375 | Glerum et al. | Nov 2011 | B2 |
| 8066524 | Burbank et al. | Nov 2011 | B2 |
| 8073335 | Labonville et al. | Dec 2011 | B2 |
| 8079950 | Stern et al. | Dec 2011 | B2 |
| 8086299 | Adler et al. | Dec 2011 | B2 |
| 8092370 | Roberts et al. | Jan 2012 | B2 |
| 8098914 | Liao et al. | Jan 2012 | B2 |
| 8100950 | St. Clair et al. | Jan 2012 | B2 |
| 8105320 | Manzo | Jan 2012 | B2 |
| 8108025 | Csavoy et al. | Jan 2012 | B2 |
| 8109877 | Moctezuma de la Barrera et al. | Feb 2012 | B2 |
| 8112292 | Simon | Feb 2012 | B2 |
| 8116430 | Shapiro et al. | Feb 2012 | B1 |
| 8120301 | Goldberg et al. | Feb 2012 | B2 |
| 8121249 | Wang et al. | Feb 2012 | B2 |
| 8123675 | Funda et al. | Feb 2012 | B2 |
| 8133229 | Bonutti | Mar 2012 | B1 |
| 8142420 | Schena | Mar 2012 | B2 |
| 8147494 | Leitner et al. | Apr 2012 | B2 |
| 8150494 | Simon et al. | Apr 2012 | B2 |
| 8150497 | Gielen et al. | Apr 2012 | B2 |
| 8150498 | Gielen et al. | Apr 2012 | B2 |
| 8165658 | Waynik et al. | Apr 2012 | B2 |
| 8170313 | Kendrick et al. | May 2012 | B2 |
| 8179073 | Farritor et al. | May 2012 | B2 |
| 8182476 | Julian et al. | May 2012 | B2 |
| 8184880 | Zhao et al. | May 2012 | B2 |
| 8202278 | Orban, III et al. | Jun 2012 | B2 |
| 8208708 | Homan et al. | Jun 2012 | B2 |
| 8208988 | Jensen | Jun 2012 | B2 |
| 8219177 | Smith et al. | Jul 2012 | B2 |
| 8219178 | Smith et al. | Jul 2012 | B2 |
| 8220468 | Cooper et al. | Jul 2012 | B2 |
| 8224024 | Foxlin et al. | Jul 2012 | B2 |
| 8224484 | Swarup et al. | Jul 2012 | B2 |
| 8225798 | Baldwin et al. | Jul 2012 | B2 |
| 8228368 | Zhao et al. | Jul 2012 | B2 |
| 8231610 | Jo et al. | Jul 2012 | B2 |
| 8263933 | Hartmann et al. | Jul 2012 | B2 |
| 8239001 | Verard et al. | Aug 2012 | B2 |
| 8241271 | Millman et al. | Aug 2012 | B2 |
| 8248413 | Gattani et al. | Aug 2012 | B2 |
| 8256319 | Cooper et al. | Sep 2012 | B2 |
| 8271069 | Jascob et al. | Sep 2012 | B2 |
| 8271130 | Hourtash | Sep 2012 | B2 |
| 8281670 | Larkin et al. | Oct 2012 | B2 |
| 8282653 | Nelson et al. | Oct 2012 | B2 |
| 8301226 | Csavoy et al. | Oct 2012 | B2 |
| 8311611 | Csavoy et al. | Nov 2012 | B2 |
| 8320991 | Jascob et al. | Nov 2012 | B2 |
| 8332012 | Kienzle, III | Dec 2012 | B2 |
| 8333755 | Cooper et al. | Dec 2012 | B2 |
| 8335552 | Stiles | Dec 2012 | B2 |
| 8335557 | Maschke | Dec 2012 | B2 |
| 8348931 | Cooper et al. | Jan 2013 | B2 |
| 8353963 | Glerum | Jan 2013 | B2 |
| 8358818 | Miga et al. | Jan 2013 | B2 |
| 8359730 | Burg et al. | Jan 2013 | B2 |
| 8374673 | Adcox et al. | Feb 2013 | B2 |
| 8374723 | Zhao et al. | Feb 2013 | B2 |
| 8379791 | Forthmann et al. | Feb 2013 | B2 |
| 8386019 | Camus et al. | Feb 2013 | B2 |
| 8392022 | Ortmaier et al. | Mar 2013 | B2 |
| 8394099 | Patwardhan | Mar 2013 | B2 |
| 8395342 | Prisco | Mar 2013 | B2 |
| 8398634 | Manzo et al. | Mar 2013 | B2 |
| 8400094 | Schena | Mar 2013 | B2 |
| 8414957 | Enzerink et al. | Apr 2013 | B2 |
| 8418073 | Mohr et al. | Apr 2013 | B2 |
| 8450694 | Baviera et al. | May 2013 | B2 |
| 8452447 | Nixon | May 2013 | B2 |
| RE44305 | Foley et al. | Jun 2013 | E |
| 8462911 | Vesel et al. | Jun 2013 | B2 |
| 8465476 | Rogers et al. | Jun 2013 | B2 |
| 8465771 | Wan et al. | Jun 2013 | B2 |
| 8467851 | Mire et al. | Jun 2013 | B2 |
| 8467852 | Csavoy et al. | Jun 2013 | B2 |
| 8469947 | Devengenzo et al. | Jun 2013 | B2 |
| RE44392 | Hynes | Jul 2013 | E |
| 8480566 | Farr | Jul 2013 | B2 |
| 8483434 | Buehner et al. | Jul 2013 | B2 |
| 8483800 | Jensen et al. | Jul 2013 | B2 |
| 8486532 | Enzerink et al. | Jul 2013 | B2 |
| 8489235 | Moll et al. | Jul 2013 | B2 |
| 8500132 | Norton | Aug 2013 | B2 |
| 8500722 | Cooper | Aug 2013 | B2 |
| 8500728 | Newton et al. | Aug 2013 | B2 |
| 8504201 | Moll et al. | Aug 2013 | B2 |
| 8506555 | Ruiz Morales | Aug 2013 | B2 |
| 8506556 | Schena | Aug 2013 | B2 |
| 8508173 | Goldberg et al. | Aug 2013 | B2 |
| 8512318 | Tovey et al. | Aug 2013 | B2 |
| 8515576 | Lipow et al. | Aug 2013 | B2 |
| 8518120 | Glerum et al. | Aug 2013 | B2 |
| 8521331 | Itkowitz | Aug 2013 | B2 |
| 8526688 | Groszmann et al. | Sep 2013 | B2 |
| 8526700 | Issacs | Sep 2013 | B2 |
| 8527094 | Kumar et al. | Sep 2013 | B2 |
| 8528440 | Morley et al. | Sep 2013 | B2 |
| 8529582 | Devengenzo et al. | Sep 2013 | B2 |
| 8532741 | Heruth et al. | Sep 2013 | B2 |
| 8541970 | Nowlin et al. | Sep 2013 | B2 |
| 8548563 | Simon et al. | Oct 2013 | B2 |
| 8549732 | Burg et al. | Oct 2013 | B2 |
| 8551114 | Ramos de la Pena | Oct 2013 | B2 |
| 8551116 | Julian et al. | Oct 2013 | B2 |
| 8556807 | Scott et al. | Oct 2013 | B2 |
| 8556979 | Glerum et al. | Oct 2013 | B2 |
| 8560118 | Green et al. | Oct 2013 | B2 |
| 8561473 | Blumenkranz | Oct 2013 | B2 |
| 8562594 | Cooper et al. | Oct 2013 | B2 |
| 8571638 | Shoham | Oct 2013 | B2 |
| 8571710 | Coste-Maniere et al. | Oct 2013 | B2 |
| 8573465 | Shelton, IV | Nov 2013 | B2 |
| 8574303 | Sharkey et al. | Nov 2013 | B2 |
| 8585420 | Burbank et al. | Nov 2013 | B2 |
| 8594841 | Zhao et al. | Nov 2013 | B2 |
| 8597198 | Sanborn et al. | Dec 2013 | B2 |
| 8600478 | Verard et al. | Dec 2013 | B2 |
| 8601667 | Norton | Dec 2013 | B2 |
| 8602971 | Farr | Dec 2013 | B2 |
| 8603077 | Cooper et al. | Dec 2013 | B2 |
| 8611985 | Lavallee et al. | Dec 2013 | B2 |
| 8613230 | Blumenkranz et al. | Dec 2013 | B2 |
| 8621939 | Blumenkranz et al. | Jan 2014 | B2 |
| 8624537 | Nowlin et al. | Jan 2014 | B2 |
| 8630389 | Kato | Jan 2014 | B2 |
| 8634897 | Simon et al. | Jan 2014 | B2 |
| 8634957 | Toth et al. | Jan 2014 | B2 |
| 8638056 | Goldberg et al. | Jan 2014 | B2 |
| 8638057 | Goldberg et al. | Jan 2014 | B2 |
| 8639000 | Zhao et al. | Jan 2014 | B2 |
| 8641726 | Bonutti | Feb 2014 | B2 |
| 8644907 | Hartmann et al. | Feb 2014 | B2 |
| 8657809 | Schoepp | Feb 2014 | B2 |
| 8660635 | Simon et al. | Feb 2014 | B2 |
| 8666544 | Moll et al. | Mar 2014 | B2 |
| 8675939 | Moctezuma de la Barrera | Mar 2014 | B2 |
| 8678647 | Gregerson et al. | Mar 2014 | B2 |
| 8679125 | Smith et al. | Mar 2014 | B2 |
| 8679183 | Glerum et al. | Mar 2014 | B2 |
| 8682413 | Lloyd | Mar 2014 | B2 |
| 8684253 | Giordano et al. | Apr 2014 | B2 |
| 8685098 | Glerum et al. | Apr 2014 | B2 |
| 8693730 | Umasuthan et al. | Apr 2014 | B2 |
| 8694075 | Groszmann et al. | Apr 2014 | B2 |
| 8696458 | Foxlin et al. | Apr 2014 | B2 |
| 8700123 | Okamura et al. | Apr 2014 | B2 |
| 8706086 | Glerum | Apr 2014 | B2 |
| 8706185 | Foley et al. | Apr 2014 | B2 |
| 8706301 | Zhao et al. | Apr 2014 | B2 |
| 8717430 | Simon et al. | May 2014 | B2 |
| 8727618 | Maschke et al. | May 2014 | B2 |
| 8734432 | Tuma et al. | May 2014 | B2 |
| 8738115 | Amberg et al. | May 2014 | B2 |
| 8738181 | Greer et al. | May 2014 | B2 |
| 8740882 | Jun et al. | Jun 2014 | B2 |
| 8746252 | McGrogan et al. | Jun 2014 | B2 |
| 8749189 | Nowlin et al. | Jun 2014 | B2 |
| 8749190 | Nowlin et al. | Jun 2014 | B2 |
| 8761930 | Nixon | Jun 2014 | B2 |
| 8764448 | Yang et al. | Jul 2014 | B2 |
| 8771170 | Mesallum et al. | Jul 2014 | B2 |
| 8781186 | Clements et al. | Jul 2014 | B2 |
| 8781630 | Banks et al. | Jul 2014 | B2 |
| 8784385 | Boyden et al. | Jul 2014 | B2 |
| 8786241 | Nowlin et al. | Jul 2014 | B2 |
| 8787520 | Baba | Jul 2014 | B2 |
| 8792704 | Isaacs | Jul 2014 | B2 |
| 8798231 | Notohara et al. | Aug 2014 | B2 |
| 8800838 | Shelton, IV | Aug 2014 | B2 |
| 8808164 | Hoffman et al. | Aug 2014 | B2 |
| 8812077 | Dempsey | Aug 2014 | B2 |
| 8814793 | Brabrand | Aug 2014 | B2 |
| 8816628 | Nowlin et al. | Aug 2014 | B2 |
| 8818105 | Myronenko et al. | Aug 2014 | B2 |
| 8820605 | Shelton, IV | Sep 2014 | B2 |
| 8821511 | von Jako et al. | Sep 2014 | B2 |
| 8823308 | Nowlin et al. | Sep 2014 | B2 |
| 8827996 | Scott et al. | Sep 2014 | B2 |
| 8828024 | Farritor et al. | Sep 2014 | B2 |
| 8830224 | Zhao et al. | Sep 2014 | B2 |
| 8834489 | Cooper et al. | Sep 2014 | B2 |
| 8834490 | Bonutti | Sep 2014 | B2 |
| 8838270 | Druke et al. | Sep 2014 | B2 |
| 8844789 | Shelton, IV et al. | Sep 2014 | B2 |
| 8855822 | Bartol et al. | Oct 2014 | B2 |
| 8857821 | Norton et al. | Oct 2014 | B2 |
| 8858598 | Seifert et al. | Oct 2014 | B2 |
| 8860753 | Bhandarkar et al. | Oct 2014 | B2 |
| 8864751 | Prisco et al. | Oct 2014 | B2 |
| 8864798 | Weiman et al. | Oct 2014 | B2 |
| 8864833 | Glerum et al. | Oct 2014 | B2 |
| 8867703 | Shapiro et al. | Oct 2014 | B2 |
| 8870880 | Himmelberger et al. | Oct 2014 | B2 |
| 8876866 | Zappacosta et al. | Nov 2014 | B2 |
| 8880223 | Raj et al. | Nov 2014 | B2 |
| 8882803 | Iott et al. | Nov 2014 | B2 |
| 8883210 | Truncale et al. | Nov 2014 | B1 |
| 8888821 | Rezach et al. | Nov 2014 | B2 |
| 8888853 | Glerum et al. | Nov 2014 | B2 |
| 8888854 | Glerum et al. | Nov 2014 | B2 |
| 8894652 | Seifert et al. | Nov 2014 | B2 |
| 8894688 | Suh | Nov 2014 | B2 |
| 8894691 | Iott et al. | Nov 2014 | B2 |
| 8906069 | Hansell et al. | Dec 2014 | B2 |
| 8964934 | Ein-Gal | Feb 2015 | B2 |
| 8992580 | Bar et al. | Mar 2015 | B2 |
| 8996169 | Lightcap et al. | Mar 2015 | B2 |
| 9001963 | Sowards-Emmerd et al. | Apr 2015 | B2 |
| 9002076 | Khadem et al. | Apr 2015 | B2 |
| 9044190 | Rubner et al. | Jun 2015 | B2 |
| 9107683 | Hourtash et al. | Aug 2015 | B2 |
| 9125556 | Zehavi et al. | Sep 2015 | B2 |
| 9131986 | Greer et al. | Sep 2015 | B2 |
| 9215968 | Schostek et al. | Dec 2015 | B2 |
| 9308050 | Kostrzewski et al. | Apr 2016 | B2 |
| 9380984 | Li et al. | Jul 2016 | B2 |
| 9393039 | Lechner et al. | Jul 2016 | B2 |
| 9398886 | Gregerson et al. | Jul 2016 | B2 |
| 9398890 | Dong et al. | Jul 2016 | B2 |
| 9414859 | Ballard et al. | Aug 2016 | B2 |
| 9420975 | Gutfleisch et al. | Aug 2016 | B2 |
| 9492235 | Hourtash et al. | Nov 2016 | B2 |
| 9554864 | Taylor et al. | Jan 2017 | B2 |
| 9592096 | Maillet et al. | Mar 2017 | B2 |
| 9600138 | Thomas et al. | Mar 2017 | B2 |
| 9734632 | Thomas et al. | Aug 2017 | B2 |
| 9750465 | Engel et al. | Sep 2017 | B2 |
| 9757203 | Hourtash et al. | Sep 2017 | B2 |
| 9795354 | Menegaz et al. | Oct 2017 | B2 |
| 9814535 | Bar et al. | Nov 2017 | B2 |
| 9820783 | Donner et al. | Nov 2017 | B2 |
| 9833265 | Donner et al. | Nov 2017 | B2 |
| 9848922 | Tohmeh et al. | Dec 2017 | B2 |
| 9925011 | Gombert et al. | Mar 2018 | B2 |
| 9931025 | Graetzel et al. | Apr 2018 | B1 |
| 10034717 | Miller et al. | Jul 2018 | B2 |
| 10076844 | Rizk | Sep 2018 | B2 |
| 10499974 | Heim et al. | Dec 2019 | B2 |
| 10639111 | Kopp | May 2020 | B2 |
| 11419616 | Cameron | Aug 2022 | B2 |
| 20010036302 | Miller | Nov 2001 | A1 |
| 20020035321 | Bucholz et al. | Mar 2002 | A1 |
| 20040068172 | Nowinski et al. | Apr 2004 | A1 |
| 20040076259 | Jensen et al. | Apr 2004 | A1 |
| 20050049486 | Urquhart et al. | Mar 2005 | A1 |
| 20050096502 | Khalili | May 2005 | A1 |
| 20050119663 | Keyer et al. | Jun 2005 | A1 |
| 20050143651 | Verard et al. | Jun 2005 | A1 |
| 20050171558 | Abovitz et al. | Aug 2005 | A1 |
| 20050281385 | Johnson et al. | Dec 2005 | A1 |
| 20060100610 | Wallace et al. | May 2006 | A1 |
| 20060173329 | Marquart et al. | Aug 2006 | A1 |
| 20060184396 | Dennis et al. | Aug 2006 | A1 |
| 20060241416 | Marquart et al. | Oct 2006 | A1 |
| 20060291612 | Nishide et al. | Dec 2006 | A1 |
| 20070015987 | Benlloch Baviera et al. | Jan 2007 | A1 |
| 20070021738 | Hasser et al. | Jan 2007 | A1 |
| 20070038059 | Sheffer et al. | Feb 2007 | A1 |
| 20070073133 | Schoenefeld | Mar 2007 | A1 |
| 20070156121 | Millman et al. | Jul 2007 | A1 |
| 20070156157 | Nahum et al. | Jul 2007 | A1 |
| 20070167712 | Keglovich et al. | Jul 2007 | A1 |
| 20070233238 | Huynh et al. | Oct 2007 | A1 |
| 20080004523 | Jensen | Jan 2008 | A1 |
| 20080013809 | Zhu et al. | Jan 2008 | A1 |
| 20080033283 | Dellaca et al. | Feb 2008 | A1 |
| 20080046122 | Manzo et al. | Feb 2008 | A1 |
| 20080082109 | Moll et al. | Apr 2008 | A1 |
| 20080108912 | Node-Langlois | May 2008 | A1 |
| 20080108991 | von Jako | May 2008 | A1 |
| 20080109012 | Falco et al. | May 2008 | A1 |
| 20080144906 | Allred et al. | Jun 2008 | A1 |
| 20080161680 | von Jako et al. | Jul 2008 | A1 |
| 20080161682 | Kendrick et al. | Jul 2008 | A1 |
| 20080177203 | von Jako | Jul 2008 | A1 |
| 20080214922 | Hartmann et al. | Sep 2008 | A1 |
| 20080228068 | Viswanathan et al. | Sep 2008 | A1 |
| 20080228196 | Wang et al. | Sep 2008 | A1 |
| 20080235052 | Node-Langlois et al. | Sep 2008 | A1 |
| 20080269596 | Revie et al. | Oct 2008 | A1 |
| 20080269777 | Appenrodt et al. | Oct 2008 | A1 |
| 20080287771 | Anderson | Nov 2008 | A1 |
| 20080287781 | Revie et al. | Nov 2008 | A1 |
| 20080300477 | Lloyd et al. | Dec 2008 | A1 |
| 20080300478 | Zuhars et al. | Dec 2008 | A1 |
| 20080302950 | Park et al. | Dec 2008 | A1 |
| 20080306490 | Lakin et al. | Dec 2008 | A1 |
| 20080319311 | Hamadeh | Dec 2008 | A1 |
| 20090012509 | Csavoy et al. | Jan 2009 | A1 |
| 20090030428 | Omori et al. | Jan 2009 | A1 |
| 20090080737 | Battle et al. | Mar 2009 | A1 |
| 20090118742 | Hartmann et al. | May 2009 | A1 |
| 20090185655 | Koken et al. | Jul 2009 | A1 |
| 20090198121 | Hoheisel | Aug 2009 | A1 |
| 20090216113 | Meier et al. | Aug 2009 | A1 |
| 20090228019 | Gross et al. | Sep 2009 | A1 |
| 20090259123 | Navab et al. | Oct 2009 | A1 |
| 20090259230 | Khadem et al. | Oct 2009 | A1 |
| 20090264899 | Appenrodt et al. | Oct 2009 | A1 |
| 20090281417 | Hartmann et al. | Nov 2009 | A1 |
| 20100022874 | Wang et al. | Jan 2010 | A1 |
| 20100039506 | Sarvestani et al. | Feb 2010 | A1 |
| 20100125286 | Wang et al. | May 2010 | A1 |
| 20100130986 | Mailloux et al. | May 2010 | A1 |
| 20100228117 | Hartmann | Sep 2010 | A1 |
| 20100228265 | Prisco | Sep 2010 | A1 |
| 20100249571 | Jensen et al. | Sep 2010 | A1 |
| 20100274120 | Heuscher | Oct 2010 | A1 |
| 20100280363 | Skarda et al. | Nov 2010 | A1 |
| 20100294828 | Bindra et al. | Nov 2010 | A1 |
| 20100298704 | Pelissier et al. | Nov 2010 | A1 |
| 20100331858 | Simaan et al. | Dec 2010 | A1 |
| 20110022229 | Jang et al. | Jan 2011 | A1 |
| 20110077504 | Fischer et al. | Mar 2011 | A1 |
| 20110098553 | Robbins et al. | Apr 2011 | A1 |
| 20110137152 | Li | Jun 2011 | A1 |
| 20110190832 | Taylor et al. | Aug 2011 | A1 |
| 20110213384 | Jeong | Sep 2011 | A1 |
| 20110224684 | Larkin et al. | Sep 2011 | A1 |
| 20110224685 | Larkin et al. | Sep 2011 | A1 |
| 20110224686 | Larkin et al. | Sep 2011 | A1 |
| 20110224687 | Larkin et al. | Sep 2011 | A1 |
| 20110224688 | Larkin et al. | Sep 2011 | A1 |
| 20110224689 | Larkin et al. | Sep 2011 | A1 |
| 20110224825 | Larkin et al. | Sep 2011 | A1 |
| 20110230967 | O'Halloran et al. | Sep 2011 | A1 |
| 20110238080 | Ranjit et al. | Sep 2011 | A1 |
| 20110276058 | Choi et al. | Nov 2011 | A1 |
| 20110282189 | Graumann | Nov 2011 | A1 |
| 20110286573 | Schretter et al. | Nov 2011 | A1 |
| 20110295062 | Gratacos Solsona et al. | Dec 2011 | A1 |
| 20110295370 | Suh et al. | Dec 2011 | A1 |
| 20110306986 | Lee et al. | Dec 2011 | A1 |
| 20120035507 | George et al. | Feb 2012 | A1 |
| 20120046668 | Gantes | Feb 2012 | A1 |
| 20120051498 | Koishi | Mar 2012 | A1 |
| 20120053597 | Anvari et al. | Mar 2012 | A1 |
| 20120059248 | Holsing et al. | Mar 2012 | A1 |
| 20120071753 | Hunter et al. | Mar 2012 | A1 |
| 20120108954 | Schulhauser et al. | May 2012 | A1 |
| 20120123417 | Smith | May 2012 | A1 |
| 20120136372 | Amat Girbau et al. | May 2012 | A1 |
| 20120143084 | Shoham | Jun 2012 | A1 |
| 20120184839 | Woerlein | Jul 2012 | A1 |
| 20120197182 | Millman et al. | Aug 2012 | A1 |
| 20120201421 | Hailmann et al. | Aug 2012 | A1 |
| 20120226145 | Chang et al. | Sep 2012 | A1 |
| 20120235909 | Birkenbach et al. | Sep 2012 | A1 |
| 20120245596 | Meenink | Sep 2012 | A1 |
| 20120253332 | Moll | Oct 2012 | A1 |
| 20120253360 | White et al. | Oct 2012 | A1 |
| 20120256092 | Zingerman | Oct 2012 | A1 |
| 20120294498 | Popovic | Nov 2012 | A1 |
| 20120296203 | Hartmann et al. | Nov 2012 | A1 |
| 20130006267 | Odermatt et al. | Jan 2013 | A1 |
| 20130016889 | Myronenko et al. | Jan 2013 | A1 |
| 20130030571 | Ruiz Morales et al. | Jan 2013 | A1 |
| 20130035583 | Park et al. | Feb 2013 | A1 |
| 20130060146 | Yang et al. | Mar 2013 | A1 |
| 20130060337 | Petersheim et al. | Mar 2013 | A1 |
| 20130094742 | Feilkas | Apr 2013 | A1 |
| 20130096574 | Kang et al. | Apr 2013 | A1 |
| 20130113791 | Isaacs et al. | May 2013 | A1 |
| 20130116706 | Lee et al. | May 2013 | A1 |
| 20130131695 | Scarfogliero et al. | May 2013 | A1 |
| 20130144307 | Jeong et al. | Jun 2013 | A1 |
| 20130158542 | Manzo et al. | Jun 2013 | A1 |
| 20130165937 | Patwardhan | Jun 2013 | A1 |
| 20130178867 | Farritor et al. | Jul 2013 | A1 |
| 20130178868 | Roh | Jul 2013 | A1 |
| 20130178870 | Schena | Jul 2013 | A1 |
| 20130204271 | Brisson et al. | Aug 2013 | A1 |
| 20130211419 | Jensen | Aug 2013 | A1 |
| 20130211420 | Jensen | Aug 2013 | A1 |
| 20130218142 | Tuma et al. | Aug 2013 | A1 |
| 20130223702 | Holsing et al. | Aug 2013 | A1 |
| 20130225942 | Holsing et al. | Aug 2013 | A1 |
| 20130225943 | Holsing et al. | Aug 2013 | A1 |
| 20130231556 | Holsing et al. | Sep 2013 | A1 |
| 20130237995 | Lee et al. | Sep 2013 | A1 |
| 20130245375 | DiMaio et al. | Sep 2013 | A1 |
| 20130261640 | Kim et al. | Oct 2013 | A1 |
| 20130272488 | Bailey et al. | Oct 2013 | A1 |
| 20130272489 | Dickman et al. | Oct 2013 | A1 |
| 20130274761 | Devengenzo et al. | Oct 2013 | A1 |
| 20130281821 | Liu et al. | Oct 2013 | A1 |
| 20130296884 | Taylor et al. | Nov 2013 | A1 |
| 20130303887 | Holsing et al. | Nov 2013 | A1 |
| 20130307955 | Deitz et al. | Nov 2013 | A1 |
| 20130317521 | Choi et al. | Nov 2013 | A1 |
| 20130325033 | Schena et al. | Dec 2013 | A1 |
| 20130325035 | Hauck et al. | Dec 2013 | A1 |
| 20130331686 | Freysinger et al. | Dec 2013 | A1 |
| 20130331858 | Devengenzo et al. | Dec 2013 | A1 |
| 20130331861 | Yoon | Dec 2013 | A1 |
| 20130342578 | Isaacs | Dec 2013 | A1 |
| 20130345717 | Markvicka et al. | Dec 2013 | A1 |
| 20130345757 | Stad | Dec 2013 | A1 |
| 20140001235 | Shelton, IV | Jan 2014 | A1 |
| 20140012131 | Heruth et al. | Jan 2014 | A1 |
| 20140031664 | Kang et al. | Jan 2014 | A1 |
| 20140046128 | Lee et al. | Feb 2014 | A1 |
| 20140046132 | Hoeg et al. | Feb 2014 | A1 |
| 20140046340 | Wilson et al. | Feb 2014 | A1 |
| 20140049629 | Siewerdsen et al. | Feb 2014 | A1 |
| 20140058406 | Tsekos | Feb 2014 | A1 |
| 20140073914 | Lavallee et al. | Mar 2014 | A1 |
| 20140080086 | Chen | Mar 2014 | A1 |
| 20140081128 | Verard et al. | Mar 2014 | A1 |
| 20140088612 | Bartol et al. | Mar 2014 | A1 |
| 20140094694 | Moctezuma de la Barrera | Apr 2014 | A1 |
| 20140094851 | Gordon | Apr 2014 | A1 |
| 20140096369 | Matsumoto et al. | Apr 2014 | A1 |
| 20140100587 | Farritor et al. | Apr 2014 | A1 |
| 20140121676 | Kostrzewski et al. | May 2014 | A1 |
| 20140128882 | Kwak et al. | May 2014 | A1 |
| 20140135796 | Simon et al. | May 2014 | A1 |
| 20140142591 | Alvarez et al. | May 2014 | A1 |
| 20140142592 | Moon et al. | May 2014 | A1 |
| 20140148692 | Hartmann et al. | May 2014 | A1 |
| 20140163581 | Devengenzo et al. | Jun 2014 | A1 |
| 20140171781 | Stiles | Jun 2014 | A1 |
| 20140171900 | Stiles | Jun 2014 | A1 |
| 20140171965 | Loh et al. | Jun 2014 | A1 |
| 20140180308 | von Grunberg | Jun 2014 | A1 |
| 20140180309 | Seeber et al. | Jun 2014 | A1 |
| 20140187915 | Yaroshenko et al. | Jul 2014 | A1 |
| 20140188132 | Kang | Jul 2014 | A1 |
| 20140194699 | Roh et al. | Jul 2014 | A1 |
| 20140130810 | Azizian et al. | Aug 2014 | A1 |
| 20140221819 | Sarment | Aug 2014 | A1 |
| 20140222023 | Kim et al. | Aug 2014 | A1 |
| 20140228631 | Kwak et al. | Aug 2014 | A1 |
| 20140234804 | Huang et al. | Aug 2014 | A1 |
| 20140257328 | Kim et al. | Sep 2014 | A1 |
| 20140257329 | Jang et al. | Sep 2014 | A1 |
| 20140257330 | Choi et al. | Sep 2014 | A1 |
| 20140275760 | Lee et al. | Sep 2014 | A1 |
| 20140275985 | Walker et al. | Sep 2014 | A1 |
| 20140276931 | Parihar et al. | Sep 2014 | A1 |
| 20140276940 | Seo | Sep 2014 | A1 |
| 20140276944 | Farritor et al. | Sep 2014 | A1 |
| 20140288413 | Hwang et al. | Sep 2014 | A1 |
| 20140299648 | Shelton, IV et al. | Oct 2014 | A1 |
| 20140303434 | Farritor et al. | Oct 2014 | A1 |
| 20140303643 | Ha et al. | Oct 2014 | A1 |
| 20140305995 | Shelton, IV et al. | Oct 2014 | A1 |
| 20140309659 | Roh et al. | Oct 2014 | A1 |
| 20140316436 | Bar et al. | Oct 2014 | A1 |
| 20140323803 | Hoffman et al. | Oct 2014 | A1 |
| 20140324070 | Min et al. | Oct 2014 | A1 |
| 20140330288 | Date et al. | Nov 2014 | A1 |
| 20140364720 | Darrow et al. | Dec 2014 | A1 |
| 20140371577 | Maillet et al. | Dec 2014 | A1 |
| 20150039034 | Frankel et al. | Feb 2015 | A1 |
| 20150085970 | Bouhnik et al. | Mar 2015 | A1 |
| 20150146847 | Liu | May 2015 | A1 |
| 20150150524 | Yorkston et al. | Jun 2015 | A1 |
| 20150196261 | Funk | Jul 2015 | A1 |
| 20150213633 | Chang et al. | Jul 2015 | A1 |
| 20150252940 | Goodwin et al. | Sep 2015 | A1 |
| 20150335480 | Alvarez et al. | Nov 2015 | A1 |
| 20150342647 | Frankel et al. | Dec 2015 | A1 |
| 20150374217 | Sinofsky | Dec 2015 | A1 |
| 20160005194 | Schretter et al. | Jan 2016 | A1 |
| 20160058513 | Giorgi | Mar 2016 | A1 |
| 20160166329 | Langan et al. | Jun 2016 | A1 |
| 20160220320 | Crawford et al. | Aug 2016 | A1 |
| 20160235480 | Scholl et al. | Aug 2016 | A1 |
| 20160249990 | Glozman et al. | Sep 2016 | A1 |
| 20160302871 | Gregerson et al. | Oct 2016 | A1 |
| 20160320322 | Suzuki | Nov 2016 | A1 |
| 20160331335 | Gregerson et al. | Nov 2016 | A1 |
| 20170055819 | Hansen et al. | Mar 2017 | A1 |
| 20170135770 | Scholl et al. | May 2017 | A1 |
| 20170143284 | Sehnert et al. | May 2017 | A1 |
| 20170143426 | Isaacs et al. | May 2017 | A1 |
| 20170156805 | Taylor et al. | Jun 2017 | A1 |
| 20170156816 | Ibrahim | Jun 2017 | A1 |
| 20170202629 | Maillet et al. | Jul 2017 | A1 |
| 20170212723 | Atarot et al. | Jul 2017 | A1 |
| 20170215825 | Johnson et al. | Aug 2017 | A1 |
| 20170215826 | Johnson et al. | Aug 2017 | A1 |
| 20170215827 | Johnson et al. | Aug 2017 | A1 |
| 20170224358 | Kostrzewski | Aug 2017 | A1 |
| 20170231710 | Scholl et al. | Aug 2017 | A1 |
| 20170258426 | Risher-Kelly et al. | Sep 2017 | A1 |
| 20170273748 | Hourtash et al. | Sep 2017 | A1 |
| 20170296277 | Hourtash et al. | Oct 2017 | A1 |
| 20170309069 | Thomas et al. | Oct 2017 | A1 |
| 20170319289 | Neff | Nov 2017 | A1 |
| 20170333056 | Ponzer et al. | Nov 2017 | A1 |
| 20170360493 | Zucher et al. | Dec 2017 | A1 |
| 20180056527 | Farritor et al. | Mar 2018 | A1 |
| 20180153408 | Yao et al. | Jun 2018 | A1 |
| 20180228559 | Brierton et al. | Aug 2018 | A1 |
| 20180271511 | Stanton | Sep 2018 | A1 |
| 20180325610 | Cameron et al. | Nov 2018 | A1 |
| 20190000567 | Allen et al. | Jan 2019 | A1 |
| 20190029765 | Crawford et al. | Jan 2019 | A1 |
| 20190167362 | Crawford et al. | Jun 2019 | A1 |
| 20190274765 | Crawford et al. | Sep 2019 | A1 |
| Number | Date | Country |
|---|---|---|
| 202008009571 | Oct 2008 | DE |
| 102014226240 | Jun 2016 | DE |
| 3241518 | Nov 2017 | EP |
| 3375399 | Sep 2018 | EP |
| 2007508117 | Apr 2007 | JP |
| 2010-269142 | Dec 2010 | JP |
| 2013517101 | May 2013 | JP |
| 2013154138 | Aug 2013 | JP |
| 2016-514562 | May 2016 | JP |
| 2016-539681 | Dec 2016 | JP |
| 2017514581 | Jun 2017 | JP |
| 2017-524483 | Aug 2017 | JP |
| 2017-205495 | Nov 2017 | JP |
| 2018011938 | Jan 2018 | JP |
| 2018079304 | May 2018 | JP |
| 2018110841 | Jul 2018 | JP |
| 2018-532465 | Nov 2018 | JP |
| 2017203531 | Nov 2017 | WO |
| Entry |
|---|
| US 8,231,638 B2, 07/2012, Swarup et al. (withdrawn) |
| Number | Date | Country | |
|---|---|---|---|
| 20220346810 A1 | Nov 2022 | US |
| Number | Date | Country | |
|---|---|---|---|
| Parent | 16821331 | Mar 2020 | US |
| Child | 17813638 | US |
| Number | Date | Country | |
|---|---|---|---|
| Parent | 16452737 | Jun 2019 | US |
| Child | 16821331 | US | |
| Parent | 16361863 | Mar 2019 | US |
| Child | 16452737 | US |
