Patent Application
20230407291
Direct interactions with host proteins are key factors in microbial infections and provide insight into mechanisms of bacterial pathogenesis. By contrast, the collective understanding of the molecular mechanisms by which host-associated microbial communities (microbiotas) interact with host proteins is comparatively limited. This is despite widespread evidence of close physical association between select members of the microbiota and host tissues and the profound effects of the microbiome on host physiology. A limitation to better understanding direct host-microbe interactions is the paucity of systems and methods for high-throughput screening of microbial binding by host extracellular proteins—those most likely to come into contact with microbes.
Thus, there is a need in the art for improved systems and high-throughput methods for identifying microbial interactions with specific host proteins that would enable mapping of host-microbiota interactions at scale. This invention satisfies this unmet need.
In one embodiment, the invention relates to a composition for modulating an interaction of a host protein with an associated microbial cell, wherein the host protein and microbial cell are interacting partners selected from the group consisting of host protein and microbial cell interacting partners as set forth in Table 1.
In one embodiment, the modulator is an inhibitor of the host protein selected from the group consisting of the host protein listed in Table 1.
In one embodiment, the inhibitor is a small interfering RNA (siRNA), a microRNA, an antisense nucleic acid, a ribozyme, an expression vector encoding a transdominant negative mutant, an antibody, an antibody fragment, a peptide, a chemical compound or a small molecule.
In one embodiment, the modulator is an activator of a host protein listed in Table 1. In one embodiment, the activator increases one or more of transcription and translation of the host protein listed in Table 1.
In one embodiment, the activator is a nucleic acid, a protein, a peptide, a peptidomemetic, a chemical compound or a small molecule.
In one embodiment, the interaction of the host protein with the associated microbial cell is the interaction of Fusobacterium with an immune-modulatory protein. In one embodiment, the immune-modulatory protein is AGER, BTN3A3, BTNL8, C3AR, CCL5, CCR9, CD55, CD99L2, CEACAM4, CSF3, DKK1, DKK2, IL15RA, LAIR1, MADCAM1, MCAM, MERTK, NPY5R, SIRPA, SOST, TMEM149, TNFRSF10B, TNFRSF4, or TREML1. In one embodiment, the interaction of the host protein with the associated microbial cell is the interaction of Ruminococcus gnavus with CD7, TFF1, TFF2, or TFF3.
In one embodiment, the invention relates to a method of modulating an interaction of a host protein with an associated microbial cell, wherein the host protein and microbial cell are interacting partners selected from the group consisting of host protein and microbial cell interacting partners as set forth in Table 1, the method comprising contacting a host cell with a composition for modulating the interaction of the host protein and the microbial cell.
In one embodiment, the modulator is an inhibitor of a host protein listed in Table 1. In one embodiment, the inhibitor is a small interfering RNA (siRNA), a microRNA, an antisense nucleic acid, a ribozyme, an expression vector encoding a transdominant negative mutant, an antibody, an antibody fragment, a peptide, a chemical compound or a small molecule.
In one embodiment, the modulator is an activator a host protein listed in Table 1. In one embodiment, the activator increases one or more of transcription and translation of a host protein listed in Table 1. In one embodiment, the activator is a nucleic acid, a protein, a peptide, a peptidomemetic, a chemical compound or a small molecule.
In one embodiment, the invention relates to a method of treating or preventing a disease or disorder in a subject in need thereof, the method comprising administering a composition for modulating the interaction of a host protein and a microbial cell to the subject, wherein the host protein and microbial cell are interacting partners selected from the group consisting of host protein and microbial cell interacting partners as set forth in Table 1.
In one embodiment, the modulator is an inhibitor of the host protein selected from the group consisting of the host protein listed in Table 1.
In one embodiment, the inhibitor is a small interfering RNA (siRNA), a microRNA, an antisense nucleic acid, a ribozyme, an expression vector encoding a transdominant negative mutant, an antibody, an antibody fragment, a peptide, a chemical compound or a small molecule.
In one embodiment, the modulator is an activator of a host protein listed in Table 1. In one embodiment, the activator increases one or more of transcription and translation of a host protein listed in Table 1.
In one embodiment, the activator is a nucleic acid, a protein, a peptide, a peptidomemetic, a chemical compound or a small molecule.
In one embodiment, the disease or disorder is inflammatory diseases, inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), obesity, type 2 diabetes, cardiovascular disease, Alzheimer's disease, Parkinson's disease, cancer or atopy.
The following detailed description of embodiments of the invention will be better understood when read in conjunction with the appended drawings. It should be understood that the invention is not limited to the precise arrangements and instrumentalities of the embodiments shown in the drawings.
The present invention relates to systems and methods for large-scale, high-throughput mapping of host protein-microbiota interactions. The present invention is based, in part, on the optimization and validation of the BASEHIT technique and, in part, on the identification of novel host protein-microbiota interactions identified in Table 1. In some embodiments, invention provides composition and methods for modulating host protein-microbe interactions. In some embodiments, the host protein-microbe interaction is modulated to alleviate symptoms of a disease or disorder mediated by said interactions. In some embodiments, the invention provides methods of inhibiting one or more host protein-microbe interaction. In some embodiments, the invention provides methods of promoting one or more host protein-microbe interaction.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.
As used herein, each of the following terms has the meaning associated with it in this section.
The articles “a” and “an” are used herein to refer to one or to more than one (i.e., to at least one) of the grammatical object of the article. By way of example, “an element” means one element or more than one element.
“About” as used herein when referring to a measurable value such as an amount, a temporal duration, and the like, is meant to encompass variations of ±20%, ±10%, ±5%, ±1%, or ±0.1% from the specified value, as such variations are appropriate to perform the disclosed methods.
The term “activate,” as used herein, means to induce or increase an activity or function, for example, about ten percent relative to a control value. Preferably, the activity is induced or increased by 50% compared to a control value, more preferably by 75%, and even more preferably by 95%. “Activate,” as used herein, also means to increase a molecule, a reaction, an interaction, a gene, an mRNA, and/or a protein's expression, stability, function or activity by a measurable amount or to increase entirely. Activators are compounds that, e.g., bind to, partially or totally induce stimulation, increase, promote, induce activation, activate, sensitize, or up regulate a protein, a gene, and an mRNA stability, expression, function and activity, e.g., agonists.
As used herein in reference to a display library, a “barcode” refers to a unique molecular identifier to distinguish cells expressing distinct display molecules. For example, the barcode may be a unique DNA sequence within a cell that corresponds to a display molecule expressed by said cell. This barcode may be detected using methods including, but not limited to, next generation sequencing. As used herein the term “cell surface molecule” refers to a peptide, polypeptide, binding domain, ligand, lipid, or carbohydrate that is directed to the extracellular surface of the host cell. The cell surface molecule may be anchored to the cell surface by covalent binding or non-covalent binding. The cell surface molecule may include a phospholipid, carbohydrate, or protein through which it attaches to the surface of the host cell. The cell surface molecule may be a polypeptide that binds to, or is conjugated to, a phospholipid, carbohydrate, or a polypeptide on the surface of the cell. For example, the polypeptide may use a phosphatidyl-inositol-glycan (GPI) anchor to attach to the surface of the cell, such as a-agglutinins, α-agglutinins, and flocculins. The cell surface molecule may also be a transmembrane protein.
“Coding sequence” or “encoding nucleic acid” as used herein may refer to the nucleic acid (RNA or DNA molecule) that comprise a nucleotide sequence which encodes an antigen set forth herein. The coding sequence may further include initiation and termination signals operably linked to regulatory elements including a promoter and polyadenylation signal capable of directing expression in the one or more cells of an individual or mammal to whom the nucleic acid is administered. The coding sequence may further include sequences that encode signal peptides.
A “constitutive” promoter is a nucleotide sequence which, when operably linked with a polynucleotide which encodes or specifies a gene product, causes the gene product to be produced in a cell under most or all physiological conditions of the cell.
A “disease” is a state of health of an animal wherein the animal cannot maintain homeostasis, and wherein if the disease is not ameliorated then the animal's health continues to deteriorate. In contrast, a “disorder” in an animal is a state of health in which the animal is able to maintain homeostasis, but in which the animal's state of health is less favorable than it would be in the absence of the disorder. Left untreated, a disorder does not necessarily cause a further decrease in the animal's state of health.
A disease or disorder is “alleviated” if the severity of a sign or symptom of the disease, or disorder, the frequency with which such a sign or symptom is experienced by a patient, or both, is reduced.
As used herein the term “display molecule” refers to a molecule that can be localized to the surface of a target cell. The display molecule will typically comprise a first amino acid sequence to be displayed (e.g., a protein of interest, etc.) and a second amino acid sequence that anchors the display molecule to the surface of the target cell (e.g., a transmembrane domain, etc.). In certain instances, the first and second amino acid sequences are linked in a single polypeptide. In an alternative embodiment, the first and second amino acid sequences may interact with each other to anchor the first amino acid sequence to the surface of a target cell. A display molecule may comprise a peptide, polypeptide, binding domain, ligand, lipid, or carbohydrate or combination thereof. The display molecule may also comprise a tag or peptide that can be labeled so as to detect binding of the display molecule to the cell surface, or sort cells displaying said molecule.
As used herein the term “display library” refers to a plurality of cells, wherein each cell comprises a non-identical display molecule that is displayed on the surface of the cell.
As used herein the term “enrich” or “enrichment” refers to the state or process, respectively, of increasing the proportion of a species of interest within a mixed pool of species through some form of selection. For example, a protein of interest can be enriched from a mixed sample of multiple proteins using positive selection with a protein-specific antibody.
The term “expression” as used herein is defined as the transcription of a particular nucleotide sequence driven by its promoter and/or the translation of said nucleotide sequence into an amino acid sequence.
An “expression cassette” is a nucleic acid construct, generated recombinantly or synthetically, with a series of specified nucleic acid elements that permit transcription of a particular polynucleotide sequence in a host cell. An expression cassette may be part of a plasmid, viral genome, or nucleic acid fragment. Typically, an expression cassette includes a polynucleotide to be transcribed, operably linked to a promoter.
The term “gene” means the segment of DNA involved in producing a polypeptide chain. It may include regions preceding and following the coding region (leader and trailer) as well as intervening sequences (introns) between individual coding segments (exons).
As used herein, an “inducible” promoter is a nucleotide sequence which, when operably linked with a polynucleotide which encodes or specifies a gene product, causes the gene product to be produced substantially only when an inducer which corresponds to the promoter is present.
The term “inhibit,” as used herein, means to suppress or block an activity or function, for example, about ten percent relative to a control value. Preferably, the activity is suppressed or blocked by 50% compared to a control value, more preferably by 75%, and even more preferably by 95%. “Inhibit,” as used herein, also means to reduce a molecule, a reaction, an interaction, a gene, an mRNA, and/or a protein's expression, stability, function or activity by a measurable amount or to prevent entirely. Inhibitors are compounds that, e.g., bind to, partially or totally block stimulation, decrease, prevent, delay activation, inactivate, desensitize, or down regulate a protein, a gene, and an mRNA stability, expression, function and activity, e.g., antagonists.
As used herein, an “instructional material” includes a publication, a recording, a diagram, or any other medium of expression which can be used to communicate the usefulness of a compound, composition, vector, or delivery system of the invention in the kit for effecting alleviation of the various diseases or disorders recited herein. Optionally, or alternately, the instructional material can describe one or more methods of alleviating the diseases or disorders in a cell or a tissue of a mammal. The instructional material of the kit of the invention can, for example, be affixed to a container which contains the identified compound, composition, vector, or delivery system of the invention or be shipped together with a container which contains the identified compound, composition, vector, or delivery system. Alternatively, the instructional material can be shipped separately from the container with the intention that the instructional material and the compound be used cooperatively by the recipient.
“Measuring” or “measurement,” or alternatively “detecting” or “detection,” means assessing the presence, absence, quantity or amount (which can be an effective amount) of a given substance.
The term “modulate,” as used herein, refers to mediating a detectable increase or decrease in a desired response. For example, a small molecule may be used to increase or decrease the level of interaction between two proteins.
As used herein, the term “next generation sequencing” refers to sequencing methods that allow for massively parallel sequencing of clonally amplified molecules and of single nucleic acid molecules. Next generation sequencing is synonymous with “massively parallel sequencing” for most purposes. Non-limiting examples of next generation sequencing include sequencing-by-synthesis using reversible dye terminators, and sequencing-by-ligation.
The term “nucleic acid” or “polynucleotide” refers to deoxyribonucleic acids (DNA) or ribonucleic acids (RNA) and polymers thereof in either single- or double-stranded form. Unless specifically limited, the term encompasses nucleic acids containing known analogues of natural nucleotides that have similar binding properties as the reference nucleic acid and are metabolized in a manner similar to naturally occurring nucleotides. Unless otherwise indicated, a particular nucleic acid sequence also implicitly encompasses conservatively modified variants thereof (e.g., degenerate codon substitutions), alleles, orthologs, SNPs, and complementary sequences as well as the sequence explicitly indicated. Specifically, degenerate codon substitutions may be achieved by generating sequences in which the third position of one or more selected (or all) codons is substituted with mixed-base and/or deoxyinosine residues (Batzer et al., Nucleic Acid Res. 19:5081 (1991); Ohtsuka et al., J. Biol. Chem. 260:2605-2608 (1985); and Rossolini et al, Mol. Cell. Probes 8:91-98 (1994)). The term nucleic acid is used interchangeably with gene, cDNA, and mRNA encoded by a gene.
“Operably linked” as used herein may mean that expression of a gene is under the control of a promoter with which it is spatially connected. A promoter may be positioned 5′ (upstream) or 3′ (downstream) of a gene under its control. The distance between the promoter and a gene may be approximately the same as the distance between that promoter and the gene it controls in the gene from which the promoter is derived. As is known in the art, variation in this distance may be accommodated without loss of promoter function.
As used herein, a “plurality of cells” herein is meant roughly from about 103 cells to 108 or 109, with from 106 to 108 being common.
As used herein, the term “plurality of display molecules” refers to at least two copies of a display molecule displayed on the surface of a target cell. In certain instances, each unique display molecule is displayed by a different target cell.
As used herein in reference to interactions, “promote” refers to inducing or increasing an interaction between two species. For example, a small molecule may promote or increase interactions between two proteins.
“Promoter” as used herein may mean a synthetic or naturally-derived molecule which is capable of conferring, activating or enhancing expression of a nucleic acid in a cell. A promoter may comprise one or more specific transcriptional regulatory sequences to further enhance expression and/or to alter the spatial expression and/or temporal expression of same. A promoter may also comprise distal enhancer or repressor elements, which can be located as much as several thousand base pairs from the start site of transcription. A promoter may be derived from sources including viral, bacterial, fungal, plants, insects, and animals. A promoter may regulate the expression of a gene component constitutively, or differentially with respect to cell, the tissue or organ in which expression occurs or, with respect to the developmental stage at which expression occurs, or in response to external stimuli such as physiological stresses, pathogens, metal ions, or inducing agents. Representative examples of promoters include the promoters from GAL1 (galactose), PGK (phosphoglycerate kinase), ADH (alcohol dehydrogenase), AOX1 (alcohol oxidase), HIS4 (histidinol dehydrogenase), metallothionein, 3-phosphoglycerate kinase, such as enolase, glyceraldehyde-3-phosphate dehydrogenase, hexokinase, pyruvate decarboxylase, phospho-fructokinase, glucose-6-phosphate isomerase, 3-phosphoglycerate mutase, pyruvate kinase, triosephosphate isomerase, phospho-glucose isomerase, and glucokinase.
The term “regulating” as used herein can mean any method of altering the level or activity of a substrate. Non-limiting examples of regulating with regard to a protein include affecting expression (including transcription and/or translation), affecting folding, affecting degradation or protein turnover, and affecting localization of a protein. Non-limiting examples of regulating with regard to an enzyme further include affecting the enzymatic activity. “Regulator” refers to a molecule whose activity includes affecting the level or activity of a substrate. A regulator can be direct or indirect. A regulator can function to activate or inhibit or otherwise modulate its substrate.
The terms “subject”, “individual”, “patient” and the like are used interchangeably herein, and refer to any animal, or cells thereof whether in vitro or in situ, amenable to the methods described herein. In some non-limiting embodiments, the patient, subject or individual is a human. In various embodiments, the subject is a human subject, and may be of any race, sex, and age.
“Vector” as used herein may mean a nucleic acid sequence containing an origin of replication. A vector may be a plasmid, bacteriophage, bacterial artificial chromosome or yeast artificial chromosome. A vector may be a DNA or RNA vector. A vector may be either a self-replicating extrachromosomal vector or a vector which integrates into a host genome.
As used herein, the term “wild-type” refers to a gene or gene product isolated from a naturally occurring source. A wild-type gene is that which is most frequently observed in a population and is thus arbitrarily designed the “normal” or “wild-type” form of the gene. In contrast, the term “modified” or “mutant” refers to a gene or gene product that displays modifications in sequence and/or functional properties (i.e., altered characteristics) when compared to the wild-type gene or gene product. It is noted that naturally occurring mutants can be isolated; these are identified by the fact that they have altered characteristics (including altered nucleic acid sequences) when compared to the wild-type gene or gene product
Ranges: throughout this disclosure, various aspects of the invention can be presented in a range format. It should be understood that the description in range format is merely for convenience and brevity and should not be construed as an inflexible limitation on the scope of the invention. Accordingly, the description of a range should be considered to have specifically disclosed all the possible subranges as well as individual numerical values within that range. For example, description of a range such as from 1 to 6 should be considered to have specifically disclosed subranges such as from 1 to 3, from 1 to 4, from 1 to 5, from 2 to 4, from 2 to 6, from 3 to 6 etc., as well as individual numbers within that range, for example, 1, 2, 2.7, 3, 4, 5, 5.3, and 6. This applies regardless of the breadth of the range.
In one embodiment, the method relates to the identification of direct binding interactions between a host protein and a microbial cell using BASEHIT (described in WO2018208877, incorporated herein by reference). In some embodiments the invention relates to a composition for modulating the interaction of one or more host protein and a microbial cell, and methods of use thereof. Modulating the interaction of a host protein and a microbial cell can be done through a variety of well-understood means, including, but not limited to, antibodies, inhibitory nucleic acid molecules (e.g., siRNA), small molecules, proteins, drug modalities or by targeting individual bacteria that have an effect on the host.
In various embodiments, the compositions of the invention include modulators of host proteins, modulators of microbial cells, and modulators of the interaction between a host protein and a microbial cell. In some embodiments, the host protein is selected from a protein identified in Table 1. In some embodiments, the microbial cell is selected from a strain identified in Table 1.
Exemplary specific interactions that are included in Table 1, and can be modulated according to the invention include, but are not limited to, the interaction of a Streptococcus strain with BACE2, a protease involved in Alzheimer's disease; interactions between strains of Fusobacterium isolated from colon tumors and immune-modulatory proteins; and interactions between Ruminococcus gnavus strains isolated from IBD patients and proteins expressed on T cells, including CD7 and members of the TNF receptor superfamily including, but not limited to, TMEM149, TNFRSF1B, TNFRSF4, TNFRSF7, TNFRSF9. Therefore, in one embodiment, the invention includes compositions and methods for modulating the interaction of Streptococcus with BACE2. In one embodiment, the invention includes compositions and methods for modulating the interaction of Fusobacterium and immune-modulatory proteins including, but not limited to, AGER, BTN3A3, BTNL8, C3AR, CCL5, CCR9, CD55, CD99L2, CEACAM4, CSF3, DKK1, DKK2, IL15RA, LAIR1, MADCAM1, MCAM, MERTK, NPY5R, SIRPA, SOST, TMEM149, TNFRSF10B, TNFRSF4, and TREML1. In one embodiment, the invention includes compositions and methods for modulating the interaction of Ruminococcus gnavus and proteins expressed on T cells, including CD7 and members of the TNF receptor superfamily including, but not limited to, CD7, TFF1, TFF2, and TFF3. In one embodiment, the invention includes compositions and methods for modulating the interaction of Citrobacter and a fibroblast growth factor (FGF) including, but not limited to, FGF1 and FGF7.
In various embodiments, the present invention includes compositions and methods of modulating a host protein, or the interaction of a host protein with a microbial cell, or a combination thereof, to activate or increase the level of interaction between the host protein and the microbial cell.
Therefore, in various embodiments, the composition for modulating a host protein, or the interaction of a host protein with a microbial cell, or a combination thereof, increases the amount of host protein polypeptide, the amount of host protein mRNA, the amount of host protein activity, or a combination thereof.
It will be understood by one skilled in the art, based upon the disclosure provided herein, that an increase in the level of the host protein encompasses the increase in host protein expression, including transcription, translation, or both. The skilled artisan will also appreciate, once armed with the teachings of the present invention, that an increase in the level of the host protein includes an increase in host protein activity. Thus, increasing the level or activity of a host protein includes, but is not limited to, increasing the amount of the host protein polypeptide, increasing transcription, translation, or both, of a nucleic acid encoding the host protein; and it also includes increasing any activity of a host protein polypeptide as well, such that the activity results in an increase in interaction of the host protein with a microbial cell.
In some embodiments, the present invention relates to the prevention and treatment of a disease or disorder by administration of a host protein polypeptide, a recombinant host protein polypeptide, an active host protein polypeptide fragment, or an activator of host protein expression or activity.
Activation of a host protein can be assessed using a wide variety of methods, including those disclosed herein, as well as methods well-known in the art or to be developed in the future. That is, a person of skill in the art would appreciate, based upon the disclosure provided herein, that increasing the level or activity of a host protein can be readily assessed using methods that assess the level of a nucleic acid encoding the host protein (e.g., mRNA) and/or the level of host protein polypeptide in a biological sample obtained from a subject.
A host protein activator can include, but should not be construed as being limited to, a chemical compound, a protein, a peptidomemetic, an antibody, and a nucleic acid molecule. One of skill in the art would readily appreciate, based on the disclosure provided herein, that a host protein activator encompasses a chemical compound that increases the level, activity, or the like of host protein. Additionally, a host protein activator encompasses a chemically modified compound, and derivatives, as is well known to one of skill in the chemical arts.
Further, one of skill in the art would, when equipped with this disclosure and the methods exemplified herein, appreciate that a host protein activator includes such activators as discovered in the future, as can be identified by well-known criteria in the art of pharmacology, such as the physiological results of activation of host protein as described in detail herein and/or as known in the art. Therefore, the present invention is not limited in any way to any particular host protein activator as exemplified or disclosed herein; rather, the invention encompasses those activators that would be understood by one of skill in the art to be useful, as are known in the art, and as are discovered in the future.
Further methods of identifying and producing a host protein activator are well known to those of ordinary skill in the art, including, but not limited, obtaining an activator from a naturally occurring source. Alternatively, a host protein activator can be synthesized chemically. Further, one of skill in the art would appreciate, based upon the teachings provided herein, that a host protein activator can be obtained from a recombinant organism. Compositions and methods for chemically synthesizing host protein activators and for obtaining them from natural sources are well known in the art and are described in the art.
One of skill in the art will appreciate that an activator can be administered as a small molecule chemical, a protein, a nucleic acid construct encoding a protein, or combinations thereof. Numerous vectors and other compositions and methods are well known for administering a protein or a nucleic acid construct encoding a protein to cells or tissues. Therefore, the invention includes a method of administering a protein or a nucleic acid encoding a protein that is an activator of host protein.
One of skill in the art will realize that diminishing the amount or activity of a molecule that itself diminishes the amount or activity of host protein can serve to increase the amount or activity of host protein. Exemplary inhibitory compositions include, but are not limited to, antisense oligonucleotides, antibodies, small molecule chemical compounds and other inhibitory compositions as discussed elsewhere herein. Any inhibitor of a regulator of host protein is encompassed in the invention.
In some embodiments, the host protein activator compositions and methods of the invention can selectively activate the host protein. Thus, in various embodiments, the present invention relates to compositions comprising a host protein polypeptide, a recombinant host protein polypeptide, or an active host protein polypeptide fragment.
One of skill in the art will appreciate that a host protein polypeptide, a recombinant host protein polypeptide, or an active host protein polypeptide fragment can be administered singly or in any combination thereof. Further, a host protein polypeptide, a recombinant host protein polypeptide, or an active host protein polypeptide fragment can be administered singly or in any combination thereof in a temporal sense, in that they may be administered simultaneously, before, and/or after each other. One of ordinary skill in the art will appreciate, based on the disclosure provided herein, that a host protein polypeptide, a recombinant host protein polypeptide, or an active host protein polypeptide fragment can be used to prevent or treat a disease or disorder, and that an activator can be used alone or in any combination with another host protein polypeptide, recombinant host protein polypeptide, active host protein polypeptide fragment, or host protein activator to effect a therapeutic result.
One of skill in the art, when armed with the disclosure herein, would appreciate that the treating or preventing a disease or disorder encompasses administering to a subject a host protein polypeptide, a recombinant host protein polypeptide, an active host protein polypeptide fragment, or host protein activator as a preventative measure against a neurodegenerative disease or disorder. As more fully discussed elsewhere herein, methods of increasing the level or activity of a host protein encompass a wide plethora of techniques for increasing not only host protein activity, but also for increasing expression of a nucleic acid encoding host protein. Additionally, as disclosed elsewhere herein, one skilled in the art would understand, once armed with the teaching provided herein, that the present invention encompasses a method of preventing a wide variety of diseases where increased expression and/or interaction of a host protein with a microbial cell mediates, treats or prevents the disease. Further, the invention encompasses treatment or prevention of such diseases discovered in the future.
The invention encompasses administration of a host protein polypeptide, a recombinant host protein polypeptide, an active host protein polypeptide fragment, or a host protein activator to practice the methods of the invention; the skilled artisan would understand, based on the disclosure provided herein, how to formulate and administer the appropriate host protein polypeptide, recombinant host protein polypeptide, active host protein polypeptide fragment, or host protein activator to a subject. However, the present invention is not limited to any particular method of administration or treatment regimen. This is especially true where it would be appreciated by one skilled in the art, equipped with the disclosure provided herein, including the reduction to practice using an art-recognized model of a neurodegenerative disease, that methods of administering a host protein polypeptide, a recombinant host protein polypeptide, an active host protein polypeptide fragment, or host protein activator can be determined by one of skill in the pharmacological arts.
As used herein, the term “pharmaceutically-acceptable carrier” means a chemical composition with which an appropriate host protein polypeptide, recombinant host protein polypeptide, active host protein polypeptide fragment, or host protein activator, may be combined and which, following the combination, can be used to administer the appropriate host protein polypeptide, recombinant host protein polypeptide, active host protein polypeptide fragment, or host protein activator to a subject.
In various embodiments, the present invention includes compositions and methods of modulating a host protein, or the interaction of a host protein with a microbial cell, or a combination thereof, which inhibit or decrease the level of interaction between the host protein and the microbial cell.
Therefore, in various embodiments, the composition for modulating a host protein, or the interaction of a host protein with a microbial cell, or a combination thereof, decreases the amount of host protein polypeptide, the amount of host protein mRNA, the amount of host protein activity, or a combination thereof.
It will be understood by one skilled in the art, based upon the disclosure provided herein, that a decrease in the level of a host protein encompasses the decrease in the expression, including transcription, translation, or both. The skilled artisan will also appreciate, once armed with the teachings of the present invention, that a decrease in the level of the host protein includes a decrease in the activity of host protein. Thus, a decrease in the level or activity of host protein includes, but is not limited to, decreasing the amount of polypeptide of the host protein, and decreasing transcription, translation, or both, of a nucleic acid encoding the host protein; and it also includes decreasing any activity of host protein as well, wherein the activity is associated with the interaction of the host protein and a microbial cell.
In one embodiment, the composition of the invention comprises an inhibitor of host protein. In one embodiment, the inhibitor is selected from the group consisting of a small interfering RNA (siRNA), a microRNA, an antisense nucleic acid, a ribozyme, an expression vector encoding a transdominant negative mutant, an antibody, a peptide and a small molecule.
One skilled in the art will appreciate, based on the disclosure provided herein, that one way to decrease the mRNA and/or protein levels of a host protein in a cell is by reducing or inhibiting expression of the nucleic acid encoding the host protein. Thus, the protein level of the host protein in a cell can be decreased using a molecule or compound that inhibits or reduces gene expression such as, for example, siRNA, an antisense molecule or a ribozyme. However, the invention should not be limited to these examples.
In one embodiment, siRNA is used to decrease the level of host protein. RNA interference (RNAi) is a phenomenon in which the introduction of double-stranded RNA (dsRNA) into a diverse range of organisms and cell types causes degradation of the complementary mRNA. In the cell, long dsRNAs are cleaved into short 21-25 nucleotide small interfering RNAs, or siRNAs, by a ribonuclease known as Dicer. The siRNAs subsequently assemble with protein components into an RNA-induced silencing complex (RISC), unwinding in the process. Activated RISC then binds to complementary transcript by base pairing interactions between the siRNA antisense strand and the mRNA. The bound mRNA is cleaved and sequence specific degradation of mRNA results in gene silencing. See, for example, U.S. Pat. No. 6,506,559; Fire et al., 1998, Nature 391(19):306-311; Timmons et al., 1998, Nature 395:854; Montgomery et al., 1998, TIG 14 (7):255-258; David R. Engelke, Ed., RNA Interference (RNAi) Nuts & Bolts of RNAi Technology, DNA Press, Eagleville, P A (2003); and Gregory J. Hannon, Ed., RNAi A Guide to Gene Silencing, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY (2003). Soutschek et al. (2004, Nature 432:173-178) describe a chemical modification to siRNAs that aids in intravenous systemic delivery. Optimizing siRNAs involves consideration of overall G/C content, C/T content at the termini, Tm and the nucleotide content of the 3′ overhang. See, for instance, Schwartz et al., 2003, Cell, 115:199-208 and Khvorova et al., 2003, Cell 115:209-216. Therefore, the present invention also includes methods of decreasing levels of host protein at the protein level using RNAi technology.
In other related aspects, the invention includes an isolated nucleic acid encoding an inhibitor, wherein an inhibitor such as an siRNA or antisense molecule, inhibits the host protein, a derivative thereof, a regulator thereof, or a downstream effector, operably linked to a nucleic acid comprising a promoter/regulatory sequence such that the nucleic acid is preferably capable of directing expression of the protein encoded by the nucleic acid. Thus, the invention encompasses expression vectors and methods for the introduction of exogenous DNA into cells with concomitant expression of the exogenous DNA in the cells such as those described, for example, in Sambrook et al. (2012, Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory, New York) and as described elsewhere herein. In another aspect of the invention, the host protein or a regulator thereof, can be inhibited by way of inactivating and/or sequestering one or more of the host protein, or a regulator thereof. As such, inhibiting the effects of the host protein can be accomplished by using a transdominant negative mutant.
In another aspect, the invention includes a vector comprising an siRNA or antisense polynucleotide. Preferably, the siRNA or antisense polynucleotide is capable of inhibiting the expression of host protein. The incorporation of a desired polynucleotide into a vector and the choice of vectors is well-known in the art as described in, for example, Sambrook et al., supra.
The siRNA or antisense polynucleotide can be cloned into a number of types of vectors as described elsewhere herein. For expression of the siRNA or antisense polynucleotide, at least one module in each promoter functions to position the start site for RNA synthesis.
In order to assess the expression of the siRNA or antisense polynucleotide, the expression vector to be introduced into a cell can also contain either a selectable marker gene or a reporter gene or both to facilitate identification and selection of expressing cells from the population of cells sought to be transfected or infected through viral vectors. In other embodiments, the selectable marker may be carried on a separate piece of DNA and used in a co-transfection procedure. Both selectable markers and reporter genes may be flanked with appropriate regulatory sequences to enable expression in the host cells. Useful selectable markers are known in the art and include, for example, antibiotic-resistance genes, such as neomycin resistance and the like.
In one embodiment of the invention, an antisense nucleic acid sequence which is expressed by a plasmid vector is used to inhibit the host protein. The antisense expressing vector is used to transfect a mammalian cell or the mammal itself, thereby causing reduced endogenous expression of host protein.
Antisense molecules and their use for inhibiting gene expression are well known in the art (see, e.g., Cohen, 1989, In: Oligodeoxyribonucleotides, Antisense Inhibitors of Gene Expression, CRC Press). Antisense nucleic acids are DNA or RNA molecules that are complementary, as that term is defined elsewhere herein, to at least a portion of a specific mRNA molecule (Weintraub, 1990, Scientific American 262:40). In the cell, antisense nucleic acids hybridize to the corresponding mRNA, forming a double-stranded molecule thereby inhibiting the translation of genes.
The use of antisense methods to inhibit the translation of genes is known in the art, and is described, for example, in Marcus-Sakura (1988, Anal. Biochem. 172:289). Such antisense molecules may be provided to the cell via genetic expression using DNA encoding the antisense molecule as taught by Inoue, 1993, U.S. Pat. No. 5,190,931.
Alternatively, antisense molecules of the invention may be made synthetically and then provided to the cell. In some embodiments, the antisense oligomers are about 10 to about 30, since they are easily synthesized and introduced into a target cell. Synthetic antisense molecules contemplated by the invention include oligonucleotide derivatives known in the art which have improved biological activity compared to unmodified oligonucleotides (see U.S. Pat. No. 5,023,243).
Ribozymes and their use for inhibiting gene expression are also well known in the art (see, e.g., Cech et al., 1992, J. Biol. Chem. 267:17479-17482; Hampel et al., 1989, Biochemistry 28:4929-4933; Eckstein et al., International Publication No. WO 92/07065; Altman et al., U.S. Pat. No. 5,168,053). Ribozymes are RNA molecules possessing the ability to specifically cleave other single-stranded RNA in a manner analogous to DNA restriction endonucleases. Through the modification of nucleotide sequences encoding these RNAs, molecules can be engineered to recognize specific nucleotide sequences in an RNA molecule and cleave it (Cech, 1988, J. Amer. Med. Assn. 260:3030). A major advantage of this approach is the fact that ribozymes are sequence-specific.
There are two basic types of ribozymes, namely, tetrahymena-type (Hasselhoff, 1988, Nature 334:585) and hammerhead-type. Tetrahymena-type ribozymes recognize sequences which are four bases in length, while hammerhead-type ribozymes recognize base sequences 11-18 bases in length. The longer the sequence, the greater the likelihood that the sequence will occur exclusively in the target mRNA species. Consequently, hammerhead-type ribozymes are preferable to tetrahymena-type ribozymes for inactivating specific mRNA species, and 18-base recognition sequences are preferable to shorter recognition sequences which may occur randomly within various unrelated mRNA molecules.
In one embodiment of the invention, a ribozyme is used to inhibit the host protein. Ribozymes useful for inhibiting the expression of a target molecule may be designed by incorporating target sequences into the basic ribozyme structure which are complementary, for example, to the mRNA sequence of the host protein of the present invention. Ribozymes targeting the host protein may be synthesized using commercially available reagents (Applied Biosystems, Inc., Foster City, CA) or they may be genetically expressed from DNA encoding them.
When the inhibitor of the invention is a small molecule, a small molecule antagonist may be obtained using standard methods known to the skilled artisan. Such methods include chemical organic synthesis or biological means. Biological means include purification from a biological source, recombinant synthesis and in vitro translation systems, using methods well known in the art.
Combinatorial libraries of molecularly diverse chemical compounds potentially useful in treating a variety of diseases and conditions are well known in the art as are method of making the libraries. The method may use a variety of techniques well-known to the skilled artisan including solid phase synthesis, solution methods, parallel synthesis of single compounds, synthesis of chemical mixtures, rigid core structures, flexible linear sequences, deconvolution strategies, tagging techniques, and generating unbiased molecular landscapes for lead discovery vs. biased structures for lead development.
In a general method for small library synthesis, an activated core molecule is condensed with a number of building blocks, resulting in a combinatorial library of covalently linked, core-building block ensembles. The shape and rigidity of the core determines the orientation of the building blocks in shape space. The libraries can be biased by changing the core, linkage, or building blocks to target a characterized biological structure (“focused libraries”) or synthesized with less structural bias using flexible cores.
In another aspect of the invention, the host protein can be inhibited by way of inactivating and/or sequestering the host protein. As such, inhibiting the effects of host protein can be accomplished by using a transdominant negative mutant.
In some embodiments, an antibody specific for the host protein (e.g., an antagonist to host protein) may be used. In one embodiment, the antagonist is a protein and/or compound having the desirable property of interacting with a binding partner of host protein (e.g., a microbial cell) and thereby competing with the corresponding protein. In another embodiment, the antagonist is a protein and/or compound having the desirable property of interacting with the host protein and thereby sequestering the host protein.
As will be understood by one skilled in the art, any antibody that can recognize and bind to an antigen of interest is useful in the present invention. Methods of making and using antibodies are well known in the art. For example, polyclonal antibodies useful in the present invention are generated by immunizing rabbits according to standard immunological techniques well-known in the art (see, e.g., Harlow et al., 1988, In: Antibodies, A Laboratory Manual, Cold Spring Harbor, NY). Such techniques include immunizing an animal with a chimeric protein comprising a portion of another protein such as a maltose binding protein or glutathione (GSH) tag polypeptide portion, and/or a moiety such that the antigenic protein of interest is rendered immunogenic (e.g., an antigen of interest conjugated with keyhole limpet hemocyanin, KLH) and a portion comprising the respective antigenic protein amino acid residues. The chimeric proteins are produced by cloning the appropriate nucleic acids encoding the marker protein into a plasmid vector suitable for this purpose, such as but not limited to, pMAL-2 or pCMX.
However, the invention should not be construed as being limited solely to methods and compositions including these antibodies or to these portions of the antigens. Rather, the invention should be construed to include other antibodies, as that term is defined elsewhere herein, to antigens, or portions thereof. Further, the present invention should be construed to encompass antibodies, inter alia, bind to the specific antigens of interest, and they are able to bind the antigen present on Western blots, in solution in enzyme linked immunoassays, in fluorescence activated cells sorting (FACS) assays, in magnetic affinity cell sorting (MACS) assays, and in immunofluorescence microscopy of a cell transiently transfected with a nucleic acid encoding at least a portion of the antigenic protein, for example.
One skilled in the art would appreciate, based upon the disclosure provided herein, that the antibody can specifically bind with any portion of the antigen and the full-length protein can be used to generate antibodies specific therefor. However, the present invention is not limited to using the full-length protein as an immunogen. Rather, the present invention includes using an immunogenic portion of the protein to produce an antibody that specifically binds with a specific antigen. That is, the invention includes immunizing an animal using an immunogenic portion, or antigenic determinant, of the antigen.
Once armed with the sequence of a specific antigen of interest and the detailed analysis localizing the various conserved and non-conserved domains of the protein, the skilled artisan would understand, based upon the disclosure provided herein, how to obtain antibodies specific for the various portions of the antigen using methods well-known in the art or to be developed.
The skilled artisan would appreciate, based upon the disclosure provided herein, that that present invention includes use of a single antibody recognizing a single antigenic epitope but that the invention is not limited to use of a single antibody. Instead, the invention encompasses use of at least one antibody where the antibodies can be directed to the same or different antigenic protein epitopes.
The generation of polyclonal antibodies is accomplished by inoculating the desired animal with the antigen and isolating antibodies which specifically bind the antigen therefrom using standard antibody production methods such as those described in, for example, Harlow et al. (1988, In: Antibodies, A Laboratory Manual, Cold Spring Harbor, NY).
Monoclonal antibodies directed against full length or peptide fragments of a protein or peptide may be prepared using any well-known monoclonal antibody preparation procedures, such as those described, for example, in Harlow et al. (1988, In: Antibodies, A Laboratory Manual, Cold Spring Harbor, NY) and in Tuszynski et al. (1988, Blood, 72:109-115). Quantities of the desired peptide may also be synthesized using chemical synthesis technology. Alternatively, DNA encoding the desired peptide may be cloned and expressed from an appropriate promoter sequence in cells suitable for the generation of large quantities of peptide. Monoclonal antibodies directed against the peptide are generated from mice immunized with the peptide using standard procedures as referenced herein.
Nucleic acid encoding the monoclonal antibody obtained using the procedures described herein may be cloned and sequenced using technology which is available in the art, and is described, for example, in Wright et al. (1992, Critical Rev. Immunol. 12:125-168), and the references cited therein.
Further, the antibody of the invention may be “humanized” using the technology described in, for example, Wright et al., and in the references cited therein, and in Gu et al. (1997, Thrombosis and Hematocyst 77:755-759), and other methods of humanizing antibodies well-known in the art or to be developed.
The present invention also includes the use of humanized antibodies specifically reactive with epitopes of an antigen of interest. The humanized antibodies of the invention have a human framework and have one or more complementarity determining regions (CDRs) from an antibody, typically a mouse antibody, specifically reactive with an antigen of interest. When the antibody used in the invention is humanized, the antibody may be generated as described in Queen, et al. (U.S. Pat. No. 6,180,370), Wright et al., (supra) and in the references cited therein, or in Gu et al. (1997, Thrombosis and Hematocyst 77(4):755-759). The method disclosed in Queen et al. is directed in part toward designing humanized immunoglobulins that are produced by expressing recombinant DNA segments encoding the heavy and light chain complementarity determining regions (CDRs) from a donor immunoglobulin capable of binding to a desired antigen, such as an epitope on an antigen of interest, attached to DNA segments encoding acceptor human framework regions. Generally speaking, the invention in the Queen patent has applicability toward the design of substantially any humanized immunoglobulin. Queen explains that the DNA segments will typically include an expression control DNA sequence operably linked to the humanized immunoglobulin coding sequences, including naturally-associated or heterologous promoter regions. The expression control sequences can be eukaryotic promoter systems in vectors capable of transforming or transfecting eukaryotic host cells or the expression control sequences can be prokaryotic promoter systems in vectors capable of transforming or transfecting prokaryotic host cells. Once the vector has been incorporated into the appropriate host, the host is maintained under conditions suitable for high level expression of the introduced nucleotide sequences and as desired the collection and purification of the humanized light chains, heavy chains, light/heavy chain dimers or intact antibodies, binding fragments or other immunoglobulin forms may follow (Beychok, Cells of Immunoglobulin Synthesis, Academic Press, New York, (1979), which is incorporated herein by reference).
The invention also includes functional equivalents of the antibodies described herein. Functional equivalents have binding characteristics comparable to those of the antibodies, and include, for example, hybridized and single chain antibodies, as well as fragments thereof. Methods of producing such functional equivalents are disclosed in PCT Application WO 93/21319 and PCT Application WO 89/09622.
Functional equivalents include polypeptides with amino acid sequences substantially the same as the amino acid sequence of the variable or hypervariable regions of the antibodies. “Substantially the same” amino acid sequence is defined herein as a sequence with at least 70%, preferably at least about 80%, more preferably at least about 90%, even more preferably at least about 95%, and most preferably at least 99% homology to another amino acid sequence (or any integer in between 70 and 99), as determined by the FASTA search method in accordance with Pearson and Lipman, 1988 Proc. Nat'l. Acad. Sci. USA 85: 2444-2448. Chimeric or other hybrid antibodies have constant regions derived substantially or exclusively from human antibody constant regions and variable regions derived substantially or exclusively from the sequence of the variable region of a monoclonal antibody from each stable hybridoma.
In some embodiments, antibodies include functional antibody fragments for example, a Fab fragment, a single chain Fv fragment, or a heavy chain antibody (such as camelid antibodies). Single chain antibodies (scFv) or Fv fragments are polypeptides that consist of the variable region of the heavy chain of the antibody linked to the variable region of the light chain, with or without an interconnecting linker. Thus, the Fv comprises an antibody combining site.
Functional equivalents of the antibodies of the invention further include fragments of antibodies that have the same, or substantially the same, binding characteristics to those of the whole antibody. Such fragments may contain one or both Fab fragments or the F(ab′)2 fragment. In some embodiments, the antibody fragments contain all six complement determining regions of the whole antibody, although fragments containing fewer than all of such regions, such as three, four or five complement determining regions, are also functional. For example, in some embodiments, the antibody fragment is a heavy chain antibody (e.g., a nanobody) comprising three complement determining regions. The functional equivalents are members of the IgG immunoglobulin class and subclasses thereof, but may be or may combine with any one of the following immunoglobulin classes: IgM, IgA, IgD, or IgE, and subclasses thereof. Heavy chains of various subclasses, such as the IgG subclasses, are responsible for different effector functions and thus, by choosing the desired heavy chain constant region, hybrid antibodies with desired effector function are produced. Exemplary constant regions are gamma 1 (IgG1), gamma 2 (IgG2), gamma 3 (IgG3), and gamma 4 (IgG4). The light chain constant region can be of the kappa or lambda type.
The immunoglobulins of the present invention can be monovalent, divalent or polyvalent. Monovalent immunoglobulins are dimers (HL) formed of a hybrid heavy chain associated through disulfide bridges with a hybrid light chain. Divalent immunoglobulins are tetramers (H2L2) formed of two dimers associated through at least one disulfide bridge.
In one exemplary embodiment, the invention provides methods of use of the compositions of the invention to modulate one or more interaction between a host protein and associated microbe. In some embodiments, the invention provides methods of modulating the interaction of a host protein with the associated microbe as listed in Table 1. For example, in some embodiments, the invention provides methods of inhibiting the interaction of Streptococcus with BACE2. In some embodiments, the invention provides methods of inhibiting the interaction of Fusobacterium with immune-modulatory proteins. In some embodiments, the invention provides methods of inhibiting the interaction of Ruminococcus gnavus with one or more proteins expressed on T cells, including CD7 and members of the TNF receptor superfamily including, but not limited to, TMEM149, TNFRSF1B, TNFRSF4, TNFRSF7, TNFRSF9. In one embodiment, the invention provides methods of inhibiting the interaction of Citrobacter and a fibroblast growth factor (FGF) including, but not limited to, FGF1 and FGF7.
In one embodiment, the present invention provides methods for treatment, inhibition, prevention, or reduction of a disease or disorder in a subject in need thereof using modulator of the invention.
In one embodiment, the disease or disorder is associated with a commensal bacterium. Exemplary commensal microbes include, but are not limited to, peptostreptococcus spp., clostridium spp., lactobacillus spp. (Lactobacillus acidophilus, Lactobacillus crispatus, Lactobacillus johnsonii, Lactobacillus sakei, Lactobacillus bulgaris, Lactobacillus jensenii, Lactobacillus rhamonsus, Lactobacillus reuteri, Lactobacillus casei var rhamnosus, Lactobacillus gasseri, Lactobacillus fermentum, Lactobacillus iners, Lactobacillus helveticus, Lactobacillus leichmannii, Lactobacillus brevis, Lactobacillus plantarum, Lactobacillus delbrueckii, Lactobacillus vaginalis, Lactobacillus salivarius, Lactobacillus coleohominis, Lactobacillus pentosus, propionibacerium spp., eubacterium spp., bifidobacterium spp., prevotella spp., bacteroides spp., fusobacterium spp., veillonella spp., diphtheroides spp., and actinomycetales spp.
In one embodiment, the disease or disorder is associated with at least one potentially pathogenic commensal microbe (i.e., pathobiont). Exemplary pathobionts include, but are not limited to, helicobacter spp., segmented filamentous bacteria, pathogenic Bacteroides fragilis strains, pathogenic Enterobacter spp., pathogenic Prevotellaceae spp., pathogenic Erysipelotrichaceae spp., Klebsiella spp. and pathogenic Clostridia spp.
In one embodiment, the disease or disorder is associated with a strain of Erysipelotrichaceae or Proteus mirabilis such as, but not limited to, Erysiptelotrichaceae strain NWP_0324 (“Ery128”), Proteus mirabilis strain WGLW6 (NWP59).
Examples of diseases or disorders that can be treated or prevented by modulating host-microbiome interactions include, but are not limited to inflammatory diseases, inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), obesity, type 2 diabetes, cardiovascular disease, Alzheimer's disease, Parkinson's disease, cancer and atopy.
In one exemplary embodiment, the method includes treating or preventing Alzheimer's disease through inhibiting the interaction of Streptococcus with BACE2. In one exemplary embodiment, the method includes treating or preventing cancer through inhibiting the interaction of Fusobacterium with immune-modulatory proteins including, but not limited to, AGER, BTN3A3, BTNL8, C3AR, CCL5, CCR9, CD55, CD99L2, CEACAM4, CSF3, DKK1, DKK2, IL15RA, LAIR1, MADCAM1, MCAM, MERTK, NPY5R, SIRPA, SOST, TMEM149, TNFRSF10B, TNFRSF4, and TREML1. In some embodiments, the cancer is colon cancer.
In one exemplary embodiment, the method includes treating or preventing inflammatory diseases such as IBD through inhibiting the interaction of Ruminococcus gnavus with proteins expressed on T cells, including CD7, TFF1, TFF2, and TFF3. In one embodiment, the method includes methods of treating or preventing inflammatory diseases such as IBD through inhibiting the interaction of RG151 or NWP327 to proteins expressed on T cells, including CD7, TFF1, TFF2, and TFF3.
In one embodiment, the method includes treating or preventing inflammatory diseases through inhibiting the interaction of Citrobacter and a fibroblast growth factor (FGF) including, but not limited to, FGF1 and FGF7.
Therapeutic Compositions
In one embodiment, the invention relates to therapeutic composition comprising a molecule, such as a protein or peptide, that modulates a host-microbe interaction. Such a molecule (e.g., protein or peptide, etc.) and the encoding nucleic acid sequence may then serve as a target for modulating host-microbe interaction in the host organism. In one embodiment, the molecule inhibits host-microbe interactions. In one embodiment, the molecule promotes host-microbe interactions. In one embodiment, the therapeutic modulates interactions between host proteins and microbes identified using the methods according to the present invention. In one embodiment, the therapeutic modulates interactions between host proteins and microbes identified in Table 1.
In various embodiments, the invention relates to compositions comprising therapeutic agents identified using the methods described herein and their use in treating or preventing a disease or disorder associated with a microbe. In one embodiment, the invention relates to compositions comprising therapeutic agents and their use in treating or preventing a disease or disorder associated with one or more microbes as set forth in Table 1.
In one embodiment, the method of identifying a therapeutic agent that modulates a host:microbe interaction comprises performing an appropriate assay in the presence of one or more candidate agent and evaluating the effect of the agent on the ability of at least one microbe to interact with its associated host protein as set forth in Table 1. In one embodiment, the therapeutic agent is one that increases or promotes interaction of a microbe with its associated host protein. In one embodiment, the interaction is increased by at least 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 20%, 30%, 40%, 50%, 75%, 100%, or greater than 100% compared to a control value. In one embodiment, the therapeutic agent is one that decreases or inhibits interaction of a microbe with its associated host protein. In one embodiment, the interaction is decreased or inhibited by at least 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 20%, 30%, 40%, 50%, 75%, 100%, or greater than 100% compared to a control value.
In one embodiment, the present invention relates to a composition comprising a therapeutic agent that interacts with a microbe to modulate its interaction with its associated host protein. In one embodiment, the present invention relates to a composition comprising a therapeutic agent that interacts with a host protein to modulate its interaction with a microbe.
In one embodiment, the composition comprises an antibody or fragment thereof. In some embodiments, the antibody or fragment thereof is useful for therapeutic applications. For example, in some embodiments, the antibody or fragment thereof, can be used to reduce or eliminate pathogenic or potentially pathogenic commensal bacteria, or inhibit bacterial pathogenicity. In some embodiments, the antibody or fragment thereof, is modified to produce precision antibiotics that specifically target a bacteria of interest. For example, in some embodiments, the antibody or fragment thereof is fused to an antibiotic, bacteriolysin, bacteriocin, or other compound that results in the reduction of the pathogenicity of a pathogenic or potentially pathogenic commensal bacterium. For example, in one embodiment, the composition comprises an antibody or fragment thereof fused, linked, or otherwise attached to a delivery vehicle comprising an antibiotic or other agent that reduces the pathogenicity of a pathogenic or potentially pathogenic commensal bacterium. In some embodiments, the antibody or fragment thereof is fused to an agent that promotes the growth of beneficial bacteria. For example, the antibody or fragment thereof can be fused to specific growth-promoting nutrients. In one embodiment, the composition comprises an antibody or fragment thereof fused, linked, or otherwise attached to a delivery vehicle comprising a growth-promoting agent.
In one embodiment, the therapeutic agent comprises a bispecific antibody targeting both a microbe and a display molecule. Exemplary bispecific antibodies include antibodies targeting a microbe and further targeting a display molecule comprising an antibody, antibody fragment or antibody mimetic. In one embodiment, a bispecific antibody targets an IgG, IgA, IgM, or IgE antibody. Such an embodiment is useful, for example, in targeting antibodies to a microbe of interest.
In one embodiment, the bispecific antibody comprises a region that binds to a specific microbe of Table 1 to inhibit the interaction of the microbe with the associated host protein. In one embodiment, the bispecific antibody comprises a region that binds to a specific host protein of Table 1 to inhibit the interaction of the host protein with the associated microbe. In one embodiment, the bispecific antibody further comprises a region that binds to luminal IgA.
In some embodiments, the composition comprises a therapeutic or diagnostic agent comprising an affinity reagent described herein, including, but not limited to nanobodies, conventional antibodies, affibodies, anticalins, and monobodies. In some embodiments, the therapeutic or diagnostic agent comprises an antibody or fragment thereof, that specifically binds a to a specific microbe of Table 1 to detect or inhibit the interaction of the microbe with the associated host protein. In one embodiment, the therapeutic or diagnostic agent comprises an antibody or fragment thereof, that binds to a specific host protein of Table 1 to detect or inhibit the interaction of the host protein with the associated microbe.
In one embodiment, the invention relates to methods of treatment or prevention of a disease or disorder associated with a microbe using the therapeutic agents of the invention. In one embodiment, the invention relates to methods of treatment or prevention of a disease or disorder associated with at least one host-microbe interaction identified in Table 1 using the therapeutic agents of the invention. Administration of the therapeutic agent in accordance with the present invention may be continuous or intermittent, depending, for example, upon the recipient's physiological condition, whether the purpose of the administration is therapeutic or prophylactic, and other factors known to skilled practitioners. The administration of the agents of the invention may be essentially continuous over a preselected period of time or may be in a series of spaced doses. Both local and systemic administration is contemplated. The amount administered will vary depending on various factors including, but not limited to, the composition chosen, the particular disease, the weight, the physical condition, and the age of the subject, and whether prevention or treatment is to be achieved. Such factors can be readily determined by the clinician employing animal models or other test systems which are well known to the art
Kits
The present invention also pertains to kits useful in the methods of the invention. Such kits comprise various combinations of components useful in any of the methods described elsewhere herein. For example, in one embodiment, the kit comprises components useful for modulating one or more host protein-microbial cell interaction as described herein. In one embodiment, the kit contains additional components. In one embodiment, an additional component includes but is not limited to instructional material. In one embodiment, instructional material for use with a kit of the invention may be provided electronically.
The invention is further described in detail by reference to the following experimental examples. These examples are provided for purposes of illustration only, and are not intended to be limiting unless otherwise specified. Thus, the invention should in no way be construed as being limited to the following examples, but rather, should be construed to encompass any and all variations which become evident as a result of the teaching provided herein.
Without further description, it is believed that one of ordinary skill in the art can, using the preceding description and the following illustrative examples, make and utilize the present invention and practice the claimed methods. The following working examples therefore are not to be construed as limiting in any way the remainder of the disclosure.
A high-throughput technology to screen intact microbial cells for the ability to bind to human proteins displayed on the surface of yeast was developed, optimized, and deemed BASEHIT (
To enable simultaneous evaluation of potential bacterial binding to thousands of human proteins, a barcoded library of 3336 human extracellular and secreted proteins (the “exoproteome”) displayed clonally on the surface of yeast was created and validated. This library covers over 50% of the total human exoproteome and includes a broad range of transmembrane, secreted, and membrane-associated proteins with diverse protein folds, expression patterns, and biological functions.
A Draft Atlas of the Host-Microbiota Interactome
Next, BASEHIT was used to begin to map the landscape of host-microbiota interactions across diverse bacterial phylogenies and tissue sites. A collection of 519 bacterial strains isolated from the mouth, gut, lung, skin, or vagina that spanned 6 phyla and 59 genera was assembled and screened. This collection also included multiple strains from numerous species to evaluate the impact of strain variation on host-microbiome interactions. In total, over 1.7 million potential binary interactions between individual host proteins and unique bacterial strains were interrogated and 3650 predicted binding events that passed the BASEHIT score cutoff were identified (
The thousands of predicted interactions that were identified span diverse phylogenies, tissues, and proteins, and thus begin to define the distributions of interactions across bacterial taxonomies and tissues of origin, as well as host protein families and folds (
Interaction patterns also varied widely across protein families and folds. For example, 2705 (81%) of the 3336 proteins in the present library failed to interact significantly with any bacterial strains in the present culture collections, 261 proteins interacted with only one strain, and only 42 (1.2%) proteins interacted with 10 or more strains. Lack of predicted interactions was not due to failure of protein expression or aberrant protein folding in the yeast library as many non-interacting proteins were readily detected via staining with specific antibodies. Proteins that bound to multiple taxa spanned diverse protein families and folds.
Divergent Host Protein Binding Patterns Imply Functional Variation Between Phylogenetically-Related Bacterial Strains
The present collections of this Example included a deep sampling of skin-derived Staphylococcus isolates from five common Staphylococcus species, so patterns of host-microbiota interaction were compared across dozens of bacterial strains assigned to the same species (
Disease-Relevant Gut Commensals Exhibit Unique Host Protein-Binding Patterns
Next, two bacterial taxa associated with human disease, the genus Fusobacterium and the species Ruminococcus gnavus, were interrogated.
R. gnavus is enriched in inflammatory bowel disease (IBD) subjects, and 20 strain-level variation and “clade switching” correlates with IBD flares. Two R. gnavus isolates exhibited strong interactions with the T cell protein CD7. Additionally, R. gnavus has been shown to exhibit high aerotolerance and mucosal localization, which is additionally supported by the strong interaction with the mucus-associated trefoil factors TFF1, TFF2, and TFF3. These interactions may provide direct molecular insight into the mechanism of R. gnavus modulation of human inflammatory disease. Close examination of CD7 binding by R. gnavus revealed specificity towards both bacterial strains and host species. Bacterial flow cytometry of three distinct isolates, all from IBD patients, showed that two strains bound CD7 (at variable levels), while one strain showed no CD7 binding activity (
Fusobacterium species, particularly Fusobacterium nucleatum, are enriched in tumors and modulate host immunity through direct interactions. The seventeen Fusobacterium strains in the present collection spanned five tissues of origin. However, many Fusobacterium isolates bound to at least one known immunomodulatory host protein or key epithelial proteins potentially involved in tumorigenesis (
The High-Throughput Screening Tool, BASEHIT, Reveals Novel Host-Microbe Interactions
This Example identifies thousands of direct host-microbe interactions spanning a range of tissues and protein functions, offering new insight into the mechanisms by which microbes may influence host physiology and colonize host-associated niches. These interactions may underlie the ability of microbes to enter non-mucosal, supposedly “sterile”, tissues, and exert effects on the host upon entering those tissues. In particular, these data complement recent observations of tumor-associated microbiomes that influence treatment efficacy, as mechanisms for immune modulation or tissue colonization may enable selective translocation, survival, and activity of particular microbial strains into the tumor microenvironment.
Importantly, BASEHIT enables a phylogenetically unbiased description of microbial function. While some interactions were phylogenetically biased, substantial variation in individual interactions among closely related strains and shared interactions across diverse microbes were observed, highlighting that direct host interactions are not predictable simply from bacterial phylogeny. Additionally, BASEHIT does not require prior annotation of bacterial genes. As more than 40% of bacterial genes in human-associated metagenomes lack any annotated function, the ability to highlight microbes with direct host associations in a high-throughput manner will complement expanding sequencing-based efforts to define tissue-specific adaptations and effects of commensal microbes.
This Example highlights the complex network of direct host-microbe interactions present within the human microbiota. These interactions may inform the role of microbes in shaping host physiology, and reflect tissue-specific adaptations of microbes to their unique niches. They additionally reveal candidate host pathways that may control or respond to the microbiota. Additionally, a technology that vastly enhances the rate at which new host-microbe interactions may be identified in an unbiased fashion, and which is applicable to a broad range of culturable microbes, has been described herein. This functional-profiling approach should offer further insight into the mechanisms of microbial control of host physiology, the evolution of microbes in specific host-associated niches, and offer new targets for host-directed investigation into microbially mediated disease.
Streptococcus sp., Strain CM6
Lachnospiraceae sp., Oral Taxon 082, Strain F0431
Lachnospiraceae sp., Oral Taxon 107, Strain F0167
Lachnospiraceae sp., Oral Taxon 082, Strain F0431
Lachnospiraceae sp., Oral Taxon 107, Strain F0167
Lachnospiraceae sp., Strain ICM7
Escherichia coli, Strain MS 21-1
Rothia mucilaginosa, Strain CC87LB
Lactobacillus crispatus, Strain GED7749C
Staphylococcus warneri, Strain SK66
Bacteroides dorei, Strain 5_1_36/D4
Finegoldia magna, Strain SY01
Lachnospiraceae sp., Strain ICM7
Lactobacillus gasseri, Strain JV-V03
Ruminococcus gnavus, Strain NWP327
Lactobacillus jensenii, Strain 208-1
Lachnospiraceae sp., Oral Taxon 107, Strain F0167
Lactobacillus jensenii, Strain 208-1
Lactobacillus crispatus, Strain GED7749C
Lactobacillus gasseri, Strain JV-V03
Bacteroidales bacterium, Strain KA00344
Staphylococcus warneri, Strain SK66
Staphylococcus pasteuri C9
Lachnospiraceae sp., Strain ICM7
Lachnospiraceae sp., Oral Taxon 082, Strain F0431
Staphylococcus capitis B12
Staphylococcus pasteuri C9
Ruminococcus gnavus, Strain NWP327
Bacteroidales bacterium, Strain KA00344
Escherichia coli, Strain MS 21-1
Bacteroides dorei, Strain 5_1_36/D4
Bacteroides sp., Strain 4_1_36
Staphylococcus epidermidis G4
Staphylococcus warneri, Strain SK66
Lactobacillus rhamnosus, Strain LMS2-1
Lactobacillus crispatus, Strain JV-V01
Staphylococcus warneri, Strain SK66
Lactobacillus parafarraginis, Strain F0439
Oscillibacter sp., Strain KLE-1728
Prevotella disiens, Strain DNF00882
Lactobacillus crispatus, Strain JV-V01
Bacteroides fragilis, Strain CL05T00C42
Lactobacillus crispatus, Strain GED7749C
Ruminococcus gnavus, Strain NWP327
Bacteroidales bacterium, Strain KA00344
Lactobacillus jensenii, Strain EX849587VC03
Staphylococcus warneri E6
Staphylococcus warneri, Strain SK66
Staphylococcus warneri E6
Lactobacillus jensenii, Strain 269-3
Staphylococcus warneri D11
Bacteroidales bacterium, Strain KA00344
Lactobacillus parafarraginis, Strain F0439
Staphylococcus warneri D11
Lachnospiraceae bacterium, Strain AAB19
Lactobacillus crispatus, Strain GED7749C
Staphylococcus warneri D11
Capnocytophaga sputigena, Strain CC21_001D
Staphylococcus warneri E6
Bacteroides dorei, Strain 5_1_36/D4
Proteus mirabilis, Strain WGLW6
Staphylococcus pasteuri C9
Staphylococcus capitis B12
Clostridium orbiscindens, Strain CC43_001K
Lactobacillus jensenii, Strain EX849587VC03
Staphylococcus warneri D11
Staphylococcus warneri E6
Fusobacterium sp., Strain CM22
Klebsiella oxytoca, Strain MIT 10-5249
Streptococcus parasanguinis, Strain F0449
Staphylococcus warneri E4
Staphylococcus warneri E4
Staphylococcus warneri, Strain SK66
Bacteroidales bacterium, Strain KA00344
Lactobacillus jensenii, Strain 269-3
Staphylococcus warneri E4
Staphylococcus pasteuri C9
Staphylococcus epidermidis G10
Proteus mirabilis, Strain WGLW6
Prevotella melaninogenica, Strain D18
Staphylococcus warneri B9
Staphylococcus warneri E4
Ruminococcus gnavus, Strain NWP325
Streptococcus downei, Oral Taxon 594, Strain F0415
Staphylococcus pasteuri C9
Streptococcus sp., Strain OBRC6
Weissella cibaria, Strain F16_1
Prevotella nigrescens, Strain F0103
Propionibacterium acnes, Strain HL044PA1
Streptococcus sobrinus, Strain W1703
Lactobacillus jensenii, Strain EX849587VC06
Lactobacillus rhamnosus, Strain LMS2-1
Lachnospiraceae bacterium, Strain AAB26
Sporosarcina sp., Strain 2681
Achromobacter xylosoxidans, Strain C54
Fusobacterium nucleatum, Strain CTI-03
Staphylococcus capitis C11
Staphylococcus capitis A7
Propionibacterium acnes, Strain HL002PA3
Bacteroides fragilis, Strain 3_1_12
Lactobacillus crispatus, Strain GED7749C
Staphylococcus hominis, Strain C80
Fusobacterium sp., Strain CM22
Klebsiella oxytoca, Strain MIT 10-5249
Streptococcus sp., Strain CM6
Staphylococcus warneri, Strain SK66
Streptococcus downei, Oral Taxon 594, Strain F0415
Prevotella timonensis, Strain CRIS 5C-B1
Staphylococcus haemolyticus B6
Lactobacillus gasseri, Strain JV-V03
Corynebacterium sp., Strain HFH0082
Streptococcus downei, Oral Taxon 594, Strain F0415
Escherichia coli, Strain MS 85-1
Staphylococcus aureus, Strain MN8
Clostridium cadaveris, Strain CC40_001C
Fusobacterium nucleatum subsp. animalis, Oral Taxon 420, Strain F0419
Staphylococcus pasteuri G3
Streptococcus sp., Strain CM6
Staphylococcus epidermidis, Strain NIHLM067
Escherichia coli, Strain MS 110-3
Bacteroides dorei, Strain 5_1_36/D4
Lactobacillus parafarraginis, Strain F0439
Staphylococcus caprae, Strain C87
Staphylococcus warneri B9
Enterococcus faecium, Strain E417
Streptococcus downei, Oral Taxon 594, Strain F0415
Rothia mucilaginosa, Strain CC87LB
Prevotella bivia, Strain DNF00188
Staphylococcus capitis B12
Staphylococcus warneri E6
Enterococcus faecium, Strain TX0133a04
Prevotella timonensis, Strain CRIS 5C-B1
Staphylococcus warneri, Strain SK66
Staphylococcus capitis A7
Klebsiella oxytoca, Strain MIT 10-5243
Staphylococcus pasteuri E5
Staphylococcus pasteuri F12
Corynebacterium amycolatum, Strain SK46
Staphylococcus warneri E6
Enterococcus faecium, Strain TX1330
Prevotella oralis, Strain HGA0225
Klebsiella sp., Strain 4_1_44FAA
Lactobacillus parafarraginis, Strain F0439
Escherichia coli, Strain MS 115-1
Enterococcus faecium, Strain ERV165
Prevotella bivia, Strain DNF00650
Prevotella disiens, Strain DNF00882
Dermabacter sp., Strain HFH0086
Bacteroides sp., Strain AAB9
Enterococcus faecium, Strain ERV102
Veillonella sp., Oral Taxon 780, Strain F0422
Prevotella bivia, Strain DNF00650
Lactobacillus jensenii, Strain 208-1
Staphylococcus capitis A7
Staphylococcus epidermidis, Strain M23864:W2
Staphylococcus warneri D11
Catabacter hongkongensis, Strain AB8_9
Staphylococcus epidermidis, Strain NIHLM001
Staphylococcus pasteuri F11
Staphylococcus capitis A7
Streptococcus vestibularis, Strain F0396
Staphylococcus pasteuri G7
Staphylococcus capitis B12
Fusobacterium ulcerans, Strain AC2_8_11 AN FAA D5 7
Sporosarcina sp., Strain 2681
Streptococcus sp., Strain SR4
Streptococcus mitis, Strain F0392
Corynebacterium sp., Strain CMW7794
Bacteroides fragilis, Strain CL05T00C42
Propionibacterium acnes, Strain HL038PA1
Enterococcus faecalis, Strain TX2137
Coprococcus sp., Strain AAb34
Staphylococcus capitis A7
Streptococcus downei, Oral Taxon 594, Strain F0415
Staphylococcus pasteuri F12
Staphylococcus capitis D5
Staphylococcus warneri D11
Fusobacterium sp., Strain CM22
Hungatella hathewayi, Strain WAL-18680
Staphylococcus pasteuri G3
Streptococcus sobrinus, Strain W1703
Staphylococcus warneri, Strain SK66
Propionibacterium acnes, Strain HL036PA1
Micrococcus luteus, Strain SK58
Staphylococcus warneri, Strain SK66
Streptococcus parasanguinis, Strain F0449
Prevotella melaninogenica, Strain D18
Lactobacillus crispatus, Strain GED7749C
Proteus mirabilis, Strain WGLW6
Staphylococcus aureus, Strain CM05
Staphylococcus haemolyticus B5
Streptococcus anginosus, Strain F0211
Oscillibacter sp., Strain KLE-1728
Staphylococcus pasteuri F11
Staphylococcus epidermidis, Strain NIHLM001
Propionibacterium acnes, Strain HL005PA3
Lactobacillus jensenii, Strain 208-1
Staphylococcus hominis C10
Streptococcus sobrinus, Strain W1703
Streptococcus sp., Strain C150
Staphylococcus capitis B12
Peptoniphilus lacrimalis, Strain UPII 315-B
Propionibacterium acnes, Strain HL045PA1
Lachnospiraceae sp., Strain DNF00160
Bacteroidales bacterium, Strain KA00344
Staphylococcus warneri B9
Propionibacterium acnes, Strain HL060PA1
Streptococcus sobrinus, Strain W1703
Staphylococcus capitis B12
Bacteroides dorei, Strain 5_1_36/D4
Dermabacter sp., Strain HFH0086
Proteus mirabilis, Strain WGLW6
Staphylococcus warneri, Strain SK66
Streptococcus sobrinus, Strain W1703
Staphylococcus capitis A7
Allobaculum sp., Strain NWP324
Escherichia coli, Strain 83972
Prevotella sp., Oral Taxon 472, Strain F0295
Staphylococcus warneri E4
Ruminococcus gnavus, Strain NWP325
Streptococcus downei, Oral Taxon 594, Strain F0415
Staphylococcus pasteuri C9
Collinsella aerofaciens, Strain AAB3
Bacteroidales bacterium, Strain KA00344
Staphylococcus aureus, Strain CM05
Staphylococcus pasteuri G7
Finegoldia magna, Strain SY01
Corynebacterium sp., Strain HFH0082
Sporosarcina sp., Strain 2681
Staphylococcus warneri B9
Klebsiella oxytoca, Strain MIT 10-5249
Klebsiella oxytoca, Strain MIT 09-7231
Hungatella hathewayi, Strain WAL-18680
Staphylococcus warneri, Strain SK66
Staphylococcus lugdunensis, Strain M23590
Corynebacterium sp., Strain HFH0082
Escherichia coli, Strain MS 115-1
Clostridium cadaveris, Strain CC40_001C
Arthrobacter albus, Strain DNF00011
Escherichia coli, Strain MS 110-3
Oscillibacter sp., Strain KLE-1728
Propionibacterium acnes, Strain HL036PA1
Proteus mirabilis, Strain WGLW6
Prevotella oris, Strain F0302
Streptococcus downei, Oral Taxon 594, Strain F0415
Staphylococcus capitis B12
Citrobacter sp., Strain 30_2
Lactobacillus gasseri, Strain JV-V03
Escherichia coli, Strain MS 196-1
Fusobacterium nucleatum subsp. animalis, Oral Taxon 420, Strain F0419
Sporosarcina sp., Strain 2681
Prevotella bivia, Strain GED7760C
Klebsiella oxytoca, Strain MIT 10-5245
Propionibacterium acnes, Strain HL050PA2
Staphylococcus capitis B12
Micrococcus luteus, Strain SK58
Corynebacterium sp., Strain HFH0082
Dorea sp., Strain AAB35
Staphylococcus aureus, Strain CM05
Escherichia coli, Strain MS 69-1
Staphylococcus xylosus F2
Staphylococcus warneri, Strain SK66
Fusobacterium sp., Strain CM22
Streptococcus sp., Strain AS20
Enterococcus faecium, Strain TX0133a04
Bacteroides sp., Strain AAB9
Staphylococcus saprophyticus E8
Staphylococcus epidermidis C3
Staphylococcus epidermidis, Strain NIHLM023
Fusobacterium sp., Strain CM22
Acidaminococcus sp., Strain D21
Catabacter hongkongensis, Strain AB8_9
Sporosarcina sp., Strain 2681
Staphylococcus saprophyticus E8
Veillonella sp., Oral Taxon 780, Strain F0422
Staphylococcus hominis, Strain C80
Clostridium orbiscindens, Strain 1_3_50AFAA
Staphylococcus aureus, Strain CM05
Enterococcus faecium, Strain TX1330
Klebsiella oxytoca, Strain MIT 10-5242
Corynebacterium amycolatum, Strain SK46
Corynebacterium amycolatum, Strain SK46
Fusobacterium nucleatum subsp. animalis, Oral Taxon 420, Strain F0419
Finegoldia magna, Strain SY01
Corynebacterium amycolatum, Strain SK46
Escherichia coli, Strain MS 198-1
Propionibacterium acnes, Strain HL044PA1
Streptococcus sanguinis, Strain VMC66
Staphylococcus warneri E4
Clostridium difficile, Strain 002-P50-2011
Klebsiella oxytoca, Strain MIT 10-5243
Staphylococcus epidermidis, Strain NIH04008
Escherichia coli, Strain MS 110-3
Shuttleworthia sp., Strain MSX8B
Corynebacterium sp., Strain HFH0082
Streptococcus sp., Strain ACC21
Staphylococcus aureus, Strain TCH70
Bacteroides stercoris, Strain CC31F
Staphylococcus aureus, Strain TCH70
Ruminococcus gnavus, Strain AAB28
Corynebacterium sp., Strain HFH0082
Klebsiella oxytoca, Strain MIT 10-5249
Oscillibacter sp., Strain KLE-1728
Lactobacillus jensenii, Strain EX849587VC06
Enterococcus faecium, Strain TX1330
Sporosarcina sp., Strain 2681
Corynebacterium amycolatum, Strain SK46
Klebsiella sp., Strain 4_1_44FAA
Escherichia coli, Strain MS 110-3
Lactobacillus jensenii, Strain EX849587VC06
Propionibacterium acnes, Strain HL053PA1
Staphylococcus capitis B8
Plesiomonas sp., Strain HPP0020
Staphylococcus aureus, Strain CM05
Micrococcus luteus, Strain SK58
Ruminococcus gnavus, Strain NWP326
Klebsiella sp., Strain MS 92-3
Staphylococcus aureus, Strain CM05
Propionibacterium acnes, Strain HL036PA2
Enterococcus faecium, Strain TX1330
Dorea formicigenerans, Strain AAB36
Sporosarcina sp., Strain 2681
Streptococcus mitis, Strain F0392
Clostridium difficile, Strain 002-P50-2011
Prevotella sp., Oral Taxon 472, Strain F0295
Lactobacillus gasseri, Strain SV-16A-US
Staphylococcus capitis C4
Staphylococcus capitis A7
Lactobacillus jensenii, Strain EX849587VC06
Streptococcus sp., Strain OBRC6
Prevotella bivia, Strain GED7760C
Streptococcus sobrinus, Strain W1703
Erysipelotrichaceae sp., Strain 6_1_45
Streptococcus sp., Strain C150
Escherichia coli, Strain MS 115-1
Micrococcus luteus, Strain SK58
Streptococcus sp., Strain C150
Bacteroides stercoris, Strain CC31F
Streptococcus mitis, Strain F0392
Bacteroidales bacterium, Strain KA00344
Micrococcus luteus, Strain SK58
Blautia sp., Strain AAB30
Enterococcus faecium, Strain ERV165
Staphylococcus warneri, Strain SK66
Propionibacterium acnes, Strain HL007PA1
Erysipelotrichaceae sp., Strain 6_1_45
Bacteroides stercoris, Strain CC31F
Staphylococcus capitis B12
Eggerthella sp., Strain MVA1
Streptococcus sp., Strain C150
Streptococcus salivarius, Strain SK126
Escherichia coli, Strain MS 196-1
Lactobacillus jensenii, Strain 208-1
Corynebacterium sp., Strain HFH0082
Streptococcus sobrinus, Strain W1703
Enterococcus faecium, Strain E417
Staphylococcus warneri, Strain SK66
Escherichia coli, Strain MS 110-3
Rothia dentocariosa, Strain M567
Fusobacterium nucleatum subsp. animalis, Oral Taxon 420, Strain F0419
Escherichia coli, Strain MS 115-1
Escherichia coli, Strain MS 115-1
Staphylococcus saprophyticus E8
Enterococcus faecium, Strain TX1330
Acidaminococcus sp., Strain D21
Staphylococcus warneri B9
Oscillibacter sp., Strain KLE 1745
Staphylococcus lugdunensis, Strain M23590
Klebsiella oxytoca, Strain MIT 10-5249
Lactobacillus crispatus, Strain GED7749C
Lactobacillus parafarraginis, Strain F0439
Prevotella disiens, Strain DNF00882
Streptococcus sp., Strain SR1
Fusobacterium sp., Strain CM22
Clostridium orbiscindens, Strain 1_3_50AFAA
Enterococcus faecalis, Strain HH22
Propionibacterium acnes, Strain HL043PA2
Staphylococcus pasteuri C9
Fusobacterium sp., Strain CM22
Proteus mirabilis, Strain WGLW6
Staphylococcus pasteuri C9
Escherichia coli, Strain MS 16-3
Escherichia coli, Strain MS 85-1
Prevotella bivia, Strain DNF00188
Escherichia coli, Strain MS 200-1
Staphylococcus warneri B9
Enterococcus faecium, Strain ERV165
Staphylococcus warneri E6
Ruminococcus gnavus, Strain NWP325
Arthrobacter albus, Strain DNF00011
Bacteroides stercoris, Strain CC31F
Streptococcus sp., Strain C150
Streptococcus sp., Strain ACS2
Prevotella bivia, Strain DNF00650
Staphylococcus aureus, Strain TCH70
Staphylococcus warneri, Strain SK66
Propionibacterium acnes, Strain HL002PA2
Staphylococcus epidermidis, Strain NIH04008
Escherichia coli, Strain MS 85-1
Prevotella oralis, Strain HGA0225
Staphylococcus warneri D11
Escherichia coli, Strain MS 200-1
Enterococcus faecium, Strain TX1330
Enterococcus faecium, Strain E417
Lachnospiraceae sp., Strain ICM7
Klebsiella oxytoca, Strain MIT 10-5244
Megasphaera micronuciformis, Strain DNF00954
Staphylococcus aureus, Strain TCH70
Klebsiella oxytoca, Strain MIT 10-5242
Proteus mirabilis, Strain WGLW6
Fusobacterium sp., Strain CM22
Escherichia coli, Strain MS 85-1
Lactobacillus parafarraginis, Strain F0439
Staphylococcus epidermidis, Strain NIHLM040
Pseudomonas sp., Strain 2_1_26
Corynebacterium amycolatum, Strain SK46
Streptococcus mitis, Strain F0392
Staphylococcus capitis E7
Streptococcus downei, Oral Taxon 594, Strain F0415
Sporosarcina sp., Strain 2681
Propionibacterium acnes, Strain HL002PA3
Fusobacterium sp., Strain CM22
Staphylococcus caprae, Strain C87
Lactobacillus jensenii, Strain EX849587VC03
Streptococcus sobrinus, Strain W1703
Streptococcus downei, Oral Taxon 594, Strain F0415
Proteus mirabilis, Strain WGLW6
Staphylococcus capitis B12
Escherichia coli, Strain MS 21-1
Plesiomonas sp., Strain HPP0020
Prevotella melaninogenica, Strain D18
Staphylococcus epidermidis, Strain W23144
Escherichia coli, Strain MS 21-1 (AIEC/NWP38)
Escherichia coli, Strain MS 21-1 (AIEC/NWP38)
Staphylococcus capitis B12
Bacteroidales bacterium, Strain KA00344
Micrococcus luteus, Strain SK58
Weissella cibaria, Strain F16_1
Staphylococcus aureus, Strain TCH70
Propionibacterium acnes, Strain HL045PA1
Hungatella hathewayi, Strain WAL-18680
Escherichia coli, Strain 83972
Propionibacterium acnes, Strain HL043PA2
Escherichia coli, Strain MS 85-1
Staphylococcus capitis D5
Citrobacter freundii, Strain 4_7_47CFAA
Corynebacterium sp., Strain CMW7794
Allobaculum sp., Strain NWP324
Lactobacillus parafarraginis, Strain F0439
Streptococcus sobrinus, Strain W1703
Clostridium difficile, Strain 002-P50-2011
Clostridium sp., Strain MSTE9
Staphylococcus epidermidis E11
Citrobacter freundii, Strain 4_7_47CFAA
Staphylococcus epidermidis, Strain NIHLM001
Staphylococcus warneri E6
Bacteroides stercoris, Strain CC31F
Staphylococcus epidermidis, Strain NIH05001
Streptococcus mitis, Strain F0392
Propionibacterium acnes, Strain HL002PA2
Enterococcus faecalis, Strain TX2137
Oscillibacter sp., Strain KLE-1728
Staphylococcus pasteuri E5
Escherichia coli, Strain MS 110-3
Lactobacillus jensenii, Strain EX849587VC06
Bacteroides stercoris, Strain CC31F
Propionibacterium acnes, Strain HL020PA1
Prevotella bivia, Strain DNF00650
Prevotella disiens, Strain DNF00882
Sporosarcina sp., Strain 2681
Clostridium orbiscindens, Strain CC43_001K
Lactobacillus crispatus, Strain GED7749C
Enterococcus faecium, Strain ERV165
Propionibacterium acnes, Strain HL046PA2
Citrobacter sp., Strain 30_2
Peptoniphilus sp., Oral Taxon 386, Strain F0131
Staphylococcus warneri E6
Streptococcus mitis, Strain F0392
Staphylococcus saprophyticus E8
Staphylococcus aureus, Strain CM05
Streptococcus anginosus, Strain F0211
Plesiomonas sp., Strain HPP0020
Erysipelotrichaceae sp., Strain 6_1_45
Fusobacterium nucleatum subsp. animalis, Oral Taxon 420, Strain F0419
Escherichia coli, Strain MS 69-1
Acidaminococcus sp., Strain D21
Enterococcus faecium, Strain TX1330
Prevotella nigrescens, Strain F0103
Bacteroides stercoris, Strain CC31F
Enterococcus faecalis, Strain TX2137
Staphylococcus warneri F1
Propionibacterium acnes, Strain HL005PA1
Deinococcus grandis, Strain SK125
Propionibacterium acnes, Strain HL005PA4
Citrobacter sp., Strain 30_2
Lachnospiraceae bacterium, Strain AAB23
Propionibacterium acnes, Strain HL056PA1
Staphylococcus hominis, Strain SK119
Staphylococcus pasteuri E5
Erysipelotrichaceae sp., Strain 6_1_45
Sporosarcina sp., Strain 2681
Streptococcus mitis, Strain F0392
Streptococcus sp., Strain BS21
Corynebacterium amycolatum, Strain SK46
Propionibacterium acnes, Strain HL005PA2
Lactobacillus crispatus, Strain JV-V01
Corynebacterium sp., Strain HFH0082
Staphylococcus pasteuri E5
Escherichia coli, Strain MS 200-1
Escherichia coli, Strain MS 85-1
Proteus mirabilis, Strain WGLW6
Erysipelotrichaceae sp., Strain 6_1_45
Staphylococcus epidermidis, Strain NIHLM015
Staphylococcus warneri D11
Propionibacterium sp., Strain 5_U_42AFAA
Erysipelotrichaceae sp., Strain 6_1_45
Megasphaera sp., Strain DNF00912
Bacteroides dorei, Strain 5_1_36/D4
Staphylococcus aureus, Strain MN8
Plesiomonas sp., Strain HPP0020
Enterococcus faecium, Strain TX1330
Klebsiella oxytoca, Strain MIT 10-5249
Streptococcus mitis, Strain F0392
Prevotella bivia, Strain DNF00188
Staphylococcus caprae, Strain C87
Lactobacillus crispatus, Strain JV-V01
Corynebacterium sp., Strain HFH0082
Staphylococcus warneri B9
Klebsiella oxytoca, Strain MIT 09-7231
Lachnospiraceae bacterium, Strain AAB19
Erysipelotrichaceae sp., Strain 6_1_45
Escherichia coli, Strain MS 115-1
Staphylococcus epidermidis, Strain BCM0060
Escherichia sp., Strain 3_2_53FAA
Staphylococcus cohnii G11
Achromobacter xylosoxidans, Strain C54
Citrobacter freundii, Strain 4_7_47CFAA
Oscillibacter sp., Strain KLE-1728
Staphylococcus epidermidis, Strain NIHLM001
Bacteroides sp., Strain AAB9
Klebsiella sp., Strain MS 92-3
Escherichia coli, Strain MS 85-1
Citrobacter freundii, Strain 4_7_47CFAA
Staphylococcus warneri B9
Propionibacterium acnes, Strain HL027PA2
Staphylococcus aureus, Strain TCH70
Lactobacillus gasseri, Strain 224-1
Lactobacillus jensenii, Strain 269-3
Staphylococcus pasteuri C9
Propionibacterium acnes, Strain HL036PA2
Bacteroides dorei, Strain 5_1_36/D4
Erysipelotrichaceae sp., Strain 6_1_45
Fusobacterium sp., Strain CM22
Prevotella sp., Oral Taxon 317, Strain F0108
Micrococcus luteus, Strain SK58
Streptococcus sp., Strain C150
Bacillus sp., Strain DNF00233
Propionibacterium acnes, Strain HL013PA1
Prevotella timonensis, Strain CRIS 5C-B1
Lactobacillus rhamnosus, Strain LMS2-1
Propionibacterium acnes, Strain HL056PA1
Streptococcus mitis, Strain F0392
Escherichia coli, Strain MS 85-1
Propionibacterium acnes, Strain HL020PA1
Escherichia coli, Strain 83972
Bacteroides stercoris, Strain CC31F
Staphylococcus aureus, Strain TCH70
Plesiomonas sp., Strain HPP0020
Staphylococcus pasteuri E5
Propionibacterium acnes, Strain HL025PA2
Blautia sp., Strain AAB30
Streptococcus sp., Strain SR1
Escherichia coli, Strain MS 85-1
Proteus mirabilis, Strain WGLW6
Dermabacter sp., Strain HFH0086
Clostridium sp., Strain 7_2_43FAA
Sporosarcina sp., Strain 2681
Rothia dentocariosa, Strain M567
Fusobacterium nucleatum subsp. animalis, Oral Taxon 420, Strain F0419
Fusobacterium sp., Strain CM21
Proteus mirabilis, Strain WGLW6
Propionibacterium acnes, Strain HL030PA2
Escherichia coli, Strain MS 69-1
Staphylococcus warneri B9
Enterococcus faecium, Strain ERV165
Escherichia coli, Strain 83972
Bacteroides sp., Strain D20
Enterococcus faecalis, Strain HH22
Fusobacterium nucleatum subsp. animalis, Oral Taxon 420, Strain F0419
Staphylococcus pasteuri G3
Pseudomonas sp., Strain HPB0071
Eggerthella sp., Strain MVA1
Bacteroides fragilis, Strain CL05T00C42
Corynebacterium amycolatum, Strain SK46
Escherichia coli, Strain MS 110-3
Klebsiella oxytoca, Strain MIT 10-5244
Megasphaera sp., Strain DNF00912
Corynebacterium amycolatum, Strain SK46
Staphylococcus pasteuri C9
Staphylococcus pasteuri G3
Proteus mirabilis, Strain WGLW6
Lactobacillus crispatus, Strain 125-2-CHN
Escherichia coli, Strain MS 69-1
Propionibacterium acnes, Strain HL027PA2
Propionibacterium acnes, Strain HL007PA1
Staphylococcus epidermidis, Strain NIHLM040
Clostridium sp., Strain MSTE9
Streptococcus mitis, Strain F0392
Bacteroides stercoris, Strain CC31F
Fusobacterium nucleatum, Strain CTI-07
Lactobacillus parafarraginis, Strain F0439
Streptococcus sp., Strain CM7
Propionibacterium acnes, Strain HL053PA1
Staphylococcus warneri C2
Staphylococcus epidermidis, Strain NIHLM001
Streptococcus sp., Strain OBRC6
Coprococcus sp., Strain AAb34
Corynebacterium sp., Strain HFH0082
Propionibacterium acidifaciens, Oral Taxon 191, Strain F0233
Propionibacterium acnes, Strain HL037PA1
Propionibacterium acnes, Strain HL002PA1
Propionibacterium acnes, Strain HL038PA1
Propionibacterium acnes, Strain HL053PA2
Fusobacterium sp., Strain CM22
Staphylococcus warneri D11
Clostridium orbiscindens, Strain 1_3_50AFAA
Propionibacterium acnes, Strain HL030PA2
Staphylococcus pasteuri E5
Streptococcus gallolyticus subsp. gallolyticus, Strain TX20005
Staphylococcus capitis A7
Enterococcus faecium, Strain ERV165
Lactobacillus jensenii, Strain 208-1
Staphylococcus pasteuri E1
Proteus mirabilis, Strain WGLW6
Enterococcus faecium, Strain TX1330
Propionibacterium acnes, Strain HL110PA3
Streptococcus vestibularis, Strain F0396
Proteus mirabilis, Strain WGLW6
Escherichia coli, Strain MS 115-1
Prevotella bivia, Strain DNF00188
Prevotella histicola, Strain F0411
Escherichia coli, Strain MS 145-7
Klebsiella oxytoca, Strain MIT 10-5249
Pseudomonas sp., Strain 2_1_26
Staphylococcus saprophyticus F6
Propionibacterium acnes, Strain HL013PA2
Bacteroidales bacterium, Strain KA00344
Staphylococcus saprophyticus E8
Micrococcus luteus, Strain SK58
Capnocytophaga sputigena, Strain CC21_001D
Enterococcus faecium, Strain ERV165
Enterococcus faecalis, Strain TUSoD Ef11
Staphylococcus capitis B12
Staphylococcus warneri D11
Staphylococcus saprophyticus E8
Oscillibacter sp., Strain KLE-1728
Streptococcus sp., Strain ACS2
Eggerthella sp., Strain MVA1
Citrobacter freundii, Strain 4_7_47CFAA
Staphylococcus pasteuri G3
Ruminococcus gnavus, Strain NWP325
Staphylococcus capitis C11
Propionibacterium acnes, Strain HL060PA1
Clostridium difficile, Strain 002-P50-2011
Enterococcus faecium, Strain ERV102
Propionibacterium acnes, Strain HL025PA1
Propionibacterium acnes, Strain HL036PA3
Streptococcus sp., Strain SR1
Lactobacillus jensenii, Strain EX849587VC06
Fusobacterium sp., Strain CM22
Enterococcus faecium, Strain E417
Sporosarcina sp., Strain 2681
Staphylococcus epidermidis, Strain NIHLM020
Staphylococcus epidermidis F6
Arthrobacter albus, Strain DNF00011
Staphylococcus pasteuri F11
Staphylococcus pasteuri G7
Streptococcus sp., Strain SR4
Streptococcus sobrinus, Strain W1703
Streptococcus sp., Strain BS29a
Proteus mirabilis, Strain WGLW6
Streptococcus sobrinus, Strain W1703
Lactobacillus crispatus, Strain JV-V01
Eubacterium sp., Strain AS15
Escherichia coli, Strain MS 145-7
Veillonella sp., Oral Taxon 780, Strain F0422
Staphylococcus warneri B9
Staphylococcus warneri D11
Staphylococcus hominis C10
Staphylococcus warneri E6
Fusobacterium sp., Strain CM22
Bacteroides sp., Strain 4_1_36
Collinsella aerofaciens, Strain AAB3
Staphylococcus warneri, Strain SK66
Escherichia coli, Strain MS 124-1
Ruminococcus gnavus, Strain NWP326
Staphylococcus warneri E6
Bacteroides stercoris, Strain CC31F
Prevotella bivia, Strain DNF00650
Proteus mirabilis, Strain WGLW6
Staphylococcus warneri B9
Staphylococcus warneri E4
Erysipelotrichaceae sp., Strain 6_1_45
Propionibacterium acnes, Strain HL030PA1
Propionibacterium acnes, Strain HL036PA3
Lactobacillus reuteri, Strain CF48-3A
Blautia sp., Strain AAB32
Prevotella bivia, Strain DNF00650
Enterococcus faecium, Strain ERV99
Staphylococcus warneri E6
Escherichia coli, Strain MS 124-1
Dorea sp., Strain AAB35
Enterococcus faecium, Strain ERV165
Fusobacterium sp., Strain CM22
Staphylococcus saprophyticus E8
Staphylococcus epidermidis, Strain NIH04008
Staphylococcus capitis A7
Propionibacterium acnes, Strain HL005PA1
Escherichia coli, Strain MS 196-1
Lactobacillus jensenii, Strain 208-1
Lactobacillus crispatus, Strain GED7749C
Staphylococcus pasteuri E5
Prevotella bivia, Strain DNF00188
Staphylococcus warneri E6
Prevotella nigrescens, Strain F0103
Staphylococcus epidermidis, Strain NIHLM001
Lactobacillus jensenii, Strain 208-1
Staphylococcus warneri E6
Escherichia coli, Strain MS 196-1
Escherichia coli, Strain MS 69-1
Bacteroides fragilis, Strain CL03T12C07
Staphylococcus warneri, Strain SK66
Prevotella veroralis, Oral Taxon 572, Strain F0319
Staphylococcus saprophyticus G1
Staphylococcus warneri B9
Megasphaera sp., Strain DNF00912
Lactobacillus parafarraginis, Strain F0439
Staphylococcus pasteuri G7
Escherichia coli, Strain MS 115-1
Staphylococcus warneri D11
Citrobacter freundii, Strain 4_7_47CFAA
Bacteroides sp., Strain D2
Lachnospiraceae bacterium, Strain AAB19
Collinsella aerofaciens, Strain AAB3
Streptococcus sp., Strain SR1
Staphylococcus pasteuri F11
Staphylococcus pasteuri F12
Bacteroides sp., Strain D2
Klebsiella oxytoca, Strain MIT 10-5245
Citrobacter freundii, Strain 4_7_47CFAA
Enterococcus faecium, Strain ERV102
Staphylococcus warneri B9
Oscillibacter sp., Strain KLE-1728
Staphylococcus saprophyticus E8
Escherichia coli, Strain MS 110-3
Streptococcus sp., Strain C150
Erysipelotrichaceae sp., Strain 6_1_45
Eubacterium sp., Strain AS15
Staphylococcus epidermidis, Strain NIHLM023
Escherichia coli, Strain MS 110-3
Escherichia coli, Strain MS 69-1
Klebsiella sp., Strain OBRC7
Bacteroidales bacterium, Strain KA00344
Klebsiella pneumoniae subsp. pneumoniae, Strain WGLW5
Staphylococcus epidermidis, Strain M23864:W2
Staphylococcus capitis B12
Staphylococcus epidermidis, Strain NIH04008
Staphylococcus warneri E4
Prevotella oralis, Strain HGA0225
Rothia mucilaginosa, Strain CC87LB
Bacteroides fragilis, Strain CL05T00C42
Peptoniphilus sp., Oral Taxon 386, Strain F0131
Enterococcus faecium, Strain E417
Fusobacterium sp., Strain CM22
Lactobacillus parafarraginis, Strain F0439
Enterococcus faecium, Strain ERV165
Lactobacillus jensenii, Strain EX849587VC03
Prevotella denticola, Strain DNF00960
Lactobacillus jensenii, Strain 208-1
Escherichia coli, Strain MS 200-1
Staphylococcus epidermidis, Strain NIH04008
Clostridium aldenense, Strain WAL-18727
Staphylococcus warneri B9
Propionibacterium acnes, Strain HL053PA2
Escherichia coli, Strain MS 57-2
Staphylococcus hominis, Strain C80
Staphylococcus pasteuri G3
Propionibacterium acnes, Strain HL005PA4
Propionibacterium acnes, Strain HL013PA2
Enterococcus faecium, Strain TX1330
Prevotella oris, Strain F0302
Staphylococcus pasteuri F12
Proteus mirabilis, Strain WGLW6
Escherichia coli, Strain 83972
Streptococcus anginosus, Strain F0211
Staphylococcus warneri E6
Enterococcus faecium, Strain ERV165
Lachnospiraceae bacterium, Strain AAB19
Enterococcus faecium, Strain ERV102
Peptoniphilus lacrimalis, Strain DNF00528
Staphylococcus epidermidis, Strain NIH05001
Propionibacterium acidifaciens, Oral Taxon 191, Strain F0233
Proteus mirabilis, Strain WGLW6
Staphylococcus pasteuri F12
Staphylococcus epidermidis, Strain W23144
Erysipelotrichaceae sp., Strain 6_1_45
Proteus mirabilis, Strain WGLW6
Propionibacterium acnes, Strain HL059PA2
Enterococcus faecium, Strain ERV102
Corynebacterium amycolatum, Strain SK46
Fusobacterium sp., Oral Taxon 370, Strain F0437
Staphylococcus warneri E6
Klebsiella oxytoca, Strain MIT 10-5248
Escherichia coli, Strain MS 196-1
Staphylococcus pasteuri C9
Klebsiella pneumoniae subsp. pneumoniae, Strain WGLW1
Staphylococcus epidermidis C3
Micrococcus luteus, Strain SK58
Eubacterium sp., Strain AS15
Escherichia coli, Strain MS 69-1
Staphylococcus hominis B3
Proteus mirabilis, Strain WGLW6
Staphylococcus epidermidis, Strain E13A
Prevotella melaninogenica, Strain D18
Klebsiella oxytoca, Strain MIT 10-5250
Enterococcus faecalis, Strain TX2137
Staphylococcus capitis C4
Klebsiella oxytoca, Strain MIT 10-5248
Propionibacterium sp., Strain 5_U_42AFAA
Bacteroides stercoris, Strain CC31F
Staphylococcus capitis C12
Propionibacterium acnes, Strain HL050PA3
Clostridiales bacterium, Strain 3_1_39B/D5
Escherichia coli, Strain MS 85-1
Corynebacterium amycolatum, Strain SK46
Prevotella bivia, Strain DNF00188
Eggerthella sp., Strain MVA1
Klebsiella sp., Strain 1_1_55
Erysipelotrichaceae sp., Strain 6_1_45
Propionibacterium acnes, Strain HL005PA2
Streptococcus sp., Strain C150
Escherichia coli, Strain MS 196-1
Micrococcus luteus, Strain SK58
Staphylococcus saprophyticus D1
Staphylococcus warneri E6
Clostridium sp., Strain 7_2_43FAA
Staphylococcus warneri D9
Streptococcus sp., Strain C150
Blautia sp., Strain AAB31
Corynebacterium sp., Strain HFH0082
Prevotella disiens, Strain DNF00882
Erysipelotrichaceae sp., Strain 6_1_45
Staphylococcus warneri D11
Sporosarcina sp., Strain 2681
Eggerthella sp., Strain MVA1
Escherichia coli, Strain MS 124-1
Fusobacterium nucleatum, Strain CTI-07
Prevotella sp., Oral Taxon 472, Strain F0295
Enterococcus faecium, Strain E417
Citrobacter sp., Strain 30_2
Prevotella bivia, Strain DNF00650
Staphylococcus epidermidis, Strain NIHLM067
Bifidobacterium longum subsp. longum, Strain 44B
Fusobacterium sp., Strain CM21
Enterococcus faecium, Strain ERV165
Streptococcus downei, Oral Taxon 594, Strain F0415
Staphylococcus warneri E6
Propionibacterium acidifaciens, Oral Taxon 191, Strain F0233
Staphylococcus warneri E4
Klebsiella oxytoca, Strain MIT 10-5250
Erysipelotrichaceae sp., Strain 6_1_45
Bifidobacterium longum subsp. longum, Strain 44B
Corynebacterium amycolatum, Strain SK46
Propionibacterium acidifaciens, Oral Taxon 191, Strain F0233
Lachnospiraceae bacterium, Strain AAB23
Enterococcus faecium, Strain TX1330
Staphylococcus hominis B3
Streptococcus downei, Oral Taxon 594, Strain F0415
Bacteroides sp., Strain D2
Eggerthella sp., Strain MVA1
Arthrobacter albus, Strain DNF00011
Fusobacterium sp., Oral Taxon 370, Strain F0437
Bifidobacterium sp., Strain MSTE12
Escherichia coli, Strain MS 124-1
Staphylococcus saprophyticus E8
Streptococcus sp., Strain AS20
Escherichia coli, Strain MS 110-3
Escherichia coli, Strain 83972
Erysipelotrichaceae sp., Strain 6_1_45
Oscillibacter sp., Strain KLE-1728
Staphylococcus pasteuri C9
Streptococcus gallolyticus subsp. gallolyticus, Strain TX20005
Proteus mirabilis, Strain WGLW6
Bacillus sp., Strain DNF00233
Clostridium aldenense, Strain WAL-18727
Lactobacillus gasseri, Strain EX33690VC16
Peptoniphilus lacrimalis, Strain UPII 315-B
Escherichia coli, Strain MS 69-1
Rothia aeria, Oral Taxon 188, Strain F0474
Lactobacillus gasseri, Strain EX33690VC16
Shigella sp., Strain D9
Fusobacterium nucleatum, Strain CTI-02
Streptococcus vestibularis, Strain F0396
Propionibacterium acnes, Strain HL037PA1
Fusobacterium sp., Strain CM22
Escherichia coli, Strain MS 21-1
Staphylococcus warneri F1
Eggerthella sp., Strain MVA1
Staphylococcus epidermidis, Strain NIHLM018
Fusobacterium periodonticum, Strain 1_A_54/D10
Bacteroides stercoris, Strain CC31F
Fusobacterium nucleatum, Strain CTI-05
Staphylococcus epidermidis, Strain NIHLM040
Prevotella buccae, Strain D17
Staphylococcus pasteuri F11
Streptococcus downei, Oral Taxon 594, Strain F0415
Streptococcus anginosus, Strain F0211
Staphylococcus pasteuri F11
Lachnospiraceae sp., Strain DNF00160
Staphylococcus warneri, Strain SK66
Actinomyces neuii, Strain MJR8396A
Enterococcus faecium, Strain TX0133a04
Sporosarcina sp., Strain 2681
Fusobacterium nucleatum subsp. animalis, Oral Taxon 420, Strain F0419
Fusobacterium sp., Strain CM21
Lactobacillus jensenii, Strain 208-1
Plesiomonas sp., Strain HPP0020
Prevotella veroralis, Oral Taxon 572, Strain F0319
Klebsiella oxytoca, Strain MIT 10-5246
Staphylococcus pasteuri G7
Staphylococcus epidermidis, Strain BCM0060
Collinsella sp., Strain 4_8_47FAA
Prevotella timonensis, Strain CRIS 5C-B1
Ruminococcus gnavus, Strain NWP325
Enterococcus faecium, Strain ERV102
Staphylococcus capitis B12
Corynebacterium amycolatum, Strain SK46
Eubacterium infirmum, Strain F0142
Staphylococcus epidermidis, Strain NIHLM070
Proteus mirabilis, Strain WGLW6
Staphylococcus warneri E4
Streptococcus sp., Strain AS20
Propionibacterium acnes, Strain HL037PA1
Streptococcus sp., Strain AS20
Micrococcus luteus, Strain SK58
Escherichia coli, Strain MS 110-3
Plesiomonas sp., Strain HPP0020
Lactobacillus reuteri, Strain CF48-3A
Staphylococcus saprophyticus E8
Staphylococcus epidermidis C6
Streptococcus mitis, Strain F0392
Corynebacterium amycolatum, Strain SK46
Lactobacillus jensenii, Strain EX849587VC03
Propionibacterium acnes, Strain HL025PA1
Enterococcus faecium, Strain ERV165
Staphylococcus warneri E4
Staphylococcus epidermidis, Strain NIHLM018
Klebsiella oxytoca, Strain MIT 10-5246
Staphylococcus epidermidis, Strain NIHLM020
Corynebacterium sp., Strain HFH0082
Streptococcus sp., Strain SR1
Lactobacillus reuteri, Strain CF48-3A
Propionibacterium acnes, Strain HL002PA1
Bacteroidales bacterium, Strain KA00344
Bacteroides sp., Strain 4_1_36
Streptococcus mitis, Strain F0392
Fusobacterium periodonticum, Strain 2_1_31
Streptococcus sp., Strain C150
Staphylococcus hominis, Strain C80
Collinsella aerofaciens, Strain AAB3
Propionibacterium acnes, Strain HL013PA1
Fusobacterium sp., Strain CM22
Corynebacterium amycolatum, Strain SK46
Corynebacterium sp., Strain HFH0082
Staphylococcus warneri D11
Klebsiella pneumoniae subsp. pneumoniae, Strain WGLW2
Bacteroides eggerthii, Strain 1_2_48FAA
Staphylococcus epidermidis, Strain NIHLM008
Bacillus sp., Strain DNF00233
Fusobacterium sp., Strain CM22
Escherichia sp., Strain 3_2_53FAA
Klebsiella pneumoniae subsp. pneumoniae, Strain WGLW1
Staphylococcus capitis A5
Corynebacterium amycolatum, Strain SK46
Propionibacterium acnes, Strain HL044PA1
Staphylococcus epidermidis, Strain NIHLM031
Staphylococcus warneri D11
Streptococcus sp., Strain SR1
Staphylococcus capitis A7
Lachnospiraceae sp., Strain ICM7
Lactobacillus jensenii, Strain EX849587VC06
Lactobacillus jensenii, Strain EX849587VC06
Propionibacterium acidifaciens, Oral Taxon 191, Strain F0233
Streptococcus gallolyticus subsp. gallolyticus, Strain TX20005
Fusobacterium sp., Strain CM22
Klebsiella sp., Strain OBRC7
Escherichia coli, Strain 83972
Klebsiella pneumoniae subsp. pneumoniae, Strain WGLW2
Peptoniphilus sp., Oral Taxon 836, Strain F0141
Lactobacillus jensenii, Strain 208-1
Sporosarcina sp., Strain 2681
Staphylococcus capitis A7
Escherichia coli, Strain MS 85-1
Staphylococcus pasteuri C9
Escherichia coli, Strain MS 16-3
Streptococcus sp., Strain SR1
Lactobacillus crispatus, Strain JV-V01
Escherichia coli, Strain MS 196-1
Lactobacillus gasseri, Strain 224-1
Enterococcus faecium, Strain ERV165
Lactobacillus jensenii, Strain EX849587VC03
Citrobacter freundii, Strain 4_7_47CFAA
Lactobacillus jensenii, Strain 269-3
Escherichia coli, Strain MS 21-1
Bacteroides fragilis, Strain CL05T00C42
Staphylococcus warneri D9
Escherichia coli, Strain MS 196-1
Ruminococcus gnavus, Strain AAB28
Staphylococcus warneri D11
Fusobacterium sp., Oral Taxon 370, Strain F0437
Staphylococcus aureus, Strain MN8
Plesiomonas sp., Strain HPP0020
Prevotella disiens, Strain DNF00882
Staphylococcus gallinarum E9
Fusobacterium sp., Strain CM22
Enterococcus faecalis, Strain TX2137
Bacteroides stercoris, Strain CC31F
Escherichia coli, Strain MS 115-1
Klebsiella sp., Strain 1_1_55
Enterococcus faecium, Strain E417
Ruminococcus gnavus, Strain NWP326
Staphylococcus warneri B9
Bacteroides dorei, Strain 5_1_36/D4
Streptococcus salivarius, Strain SK126
Enterococcus faecium, Strain ERV102
Proteus mirabilis, Strain WGLW6
Fusobacterium sp., Oral Taxon 370, Strain F0437
Micrococcus luteus, Strain SK58
Lactobacillus parafarraginis, Strain F0439
Staphylococcus warneri F1
Dorea formicigenerans, Strain AAB36
Staphylococcus capitis, Strain SK14
Staphylococcus caprae, Strain C87
Staphylococcus capitis A7
Staphylococcus warneri B9
Streptococcus mitis, Strain F0392
Staphylococcus xylosus F2
Streptococcus downei, Oral Taxon 594, Strain F0415
Staphylococcus aureus, Strain TCH70
Proteus mirabilis, Strain WGLW6
Citrobacter freundii, Strain 4_7_47CFAA
Catabacter hongkongensis, Strain AB8_9
Staphylococcus succinus D11
Enterococcus faecium, Strain E417
Shuttleworthia sp., Strain MSX8B
Escherichia coli, Strain MS 196-1
Citrobacter sp., Strain 30_2
Plesiomonas sp., Strain HPP0020
Enterococcus faecium, Strain E417
Propionibacterium acnes, Strain HL005PA3
Fusobacterium periodonticum, Strain 2_1_31
Rhodococcus erythropolis, Strain SK121
Staphylococcus pasteuri G7
Lactobacillus parafarraginis, Strain F0439
Escherichia coli, Strain MS 119-7
Veillonella sp., Oral Taxon 780, Strain F0422
Staphylococcus warneri E4
Streptococcus sp., Strain AS20
Prevotella histicola, Strain F0411
Staphylococcus pasteuri G3
Escherichia coli, Strain MS 85-1
Proteus mirabilis, Strain WGLW6
Propionibacterium acnes, Strain HL050PA1
Klebsiella oxytoca, Strain MIT 10-5249
Megasphaera sp., Strain DNF00912
Eggerthella sp., Strain MVA1
Klebsiella oxytoca, Strain MIT 10-5249
Bacillus sp., Strain DNF00233
Shigella sp., Strain D9
Streptococcus sp., Strain OBRC6
Staphylococcus pasteuri C9
Proteus mirabilis, Strain WGLW6
Escherichia coli, Strain 83972
Escherichia coli, Strain MS 115-1
Fusobacterium nucleatum, Strain CTI-05
Enterococcus faecalis, Strain R712
Propionibacterium acnes, Strain HL060PA1
Streptococcus anginosus, Strain F0211
Streptococcus sp., Strain SR1
Catabacter hongkongensis, Strain AB8_9
Bacteroides stercoris, Strain CC31F
Bifidobacterium breve, Strain JCP7499
Fusobacterium nucleatum subsp. animalis, Oral Taxon 420, Strain F0419
Dorea sp., Strain AAB35
Streptococcus mitis, Strain F0392
Citrobacter sp., Strain 30_2
Propionibacterium acnes, Strain HL025PA1
Lactobacillus gasseri, Strain JV-V03
Prevotella nigrescens, Strain F0103
Propionibacterium acnes, Strain HL002PA1
Staphylococcus hominis, Strain C80
Lachnospiraceae bacterium, Strain AAB23
Staphylococcus caprae, Strain C87
Peptoniphilus lacrimalis, Strain UPII 315-B
Propionibacterium acidifaciens, Oral Taxon 191, Strain F0233
Staphylococcus hominis, Strain C80
Prevotella bivia, Strain DNF00188
Staphylococcus warneri C2
Sporosarcina sp., Strain 2681
Staphylococcus epidermidis, Strain NIHLM015
Enterococcus faecium, Strain E417
Staphylococcus epidermidis, Strain NIHLM031
Escherichia sp., Strain 3_2_53FAA
Lactobacillus crispatus, Strain GED7749C
Escherichia coli, Strain MS 110-3
Staphylococcus warneri D11
Staphylococcus warneri E6
Bacteroidales bacterium, Strain KA00344
Proteus mirabilis, Strain WGLW6
Catabacter hongkongensis, Strain AB8_9
Plesiomonas sp., Strain HPP0020
Staphylococcus epidermidis, Strain NIHLM003
Enterococcus faecalis, Strain R712
Staphylococcus caprae, Strain C87
Erysipelotrichaceae sp., Strain 6_1_45
Propionibacterium acnes, Strain HL013PA1
Streptococcus downei, Oral Taxon 594, Strain F0415
Escherichia coli, Strain MS 200-1
Bacteroides stercoris, Strain CC31F
Escherichia coli, Strain MS 69-1
Clostridium sp., Strain MSTE9
Proteus mirabilis, Strain WGLW6
Lactobacillus jensenii, Strain 269-3
Plesiomonas sp., Strain HPP0020
Staphylococcus aureus, Strain TCH70
Lactobacillus parafarraginis, Strain F0439
Staphylococcus haemolyticus B5
Sporosarcina sp., Strain 2681
Enterococcus faecalis, Strain S613
Fusobacterium nucleatum, Strain CTI-02
Oscillibacter sp., Strain KLE 1745
Escherichia coli, Strain MS 85-1
Staphylococcus capitis B12
Erysipelotrichaceae sp., Strain 6_1_45
Propionibacterium acnes, Strain HL050PA3
Staphylococcus warneri E6
Fusobacterium sp., Strain CM21
Arthrobacter albus, Strain DNF00011
Eubacterium infirmum, Strain F0142
Enterococcus faecium, Strain E417
Weissella cibaria, Strain F16_1
Bacteroides vulgatus, Strain CL09T03C04
Escherichia coli, Strain MS 115-1
Staphylococcus epidermidis, Strain NIHLM040
Staphylococcus warneri B9
Escherichia coli, Strain MS 115-1
Staphylococcus epidermidis, Strain NIHLM001
Staphylococcus saprophyticus E8
Plesiomonas sp., Strain HPP0020
Lactobacillus parafarraginis, Strain F0439
Clostridium difficile, Strain 050-P50-2011
Fusobacterium nucleatum, Strain CTI-07
Streptococcus mitis, Strain F0392
Corynebacterium amycolatum, Strain SK46
Lactobacillus jensenii, Strain 208-1
Bacteroides stercoris, Strain CC31F
Enterococcus faecium, Strain E417
Staphylococcus warneri D4
Enterococcus faecium, Strain TX0133a04
Streptococcus parasanguinis, Strain F0449
Propionibacterium acnes, Strain HL053PA2
Shigella sp., Strain D9
Staphylococcus capitis C4
Finegoldia magna, Strain GED7760A
Enterococcus faecium, Strain E417
Lachnospiraceae bacterium, Strain AAB19
Staphylococcus succinus D11
Staphylococcus warneri F1
Prevotella bivia, Strain DNF00650
Proteus mirabilis, Strain WGLW4
Proteus mirabilis, Strain WGLW6
Streptococcus sp., Strain C150
Arthrobacter albus, Strain DNF00011
Bacteroides dorei, Strain 5_1_36/D4
Lactobacillus crispatus, Strain GED7749C
Proteus mirabilis, Strain WGLW6
Lactobacillus reuteri, Strain CF48-3A
Prevotella sp., Oral Taxon 317, Strain F0108
Klebsiella oxytoca, Strain MIT 10-5242
Streptococcus anginosus, Strain F0211
Escherichia coli, Strain MS 69-1
Fusobacterium sp., Oral Taxon 370, Strain F0437
Streptococcus sp., Strain SR1
Propionibacterium acnes, Strain HL025PA2
Citrobacter freundii, Strain 4_7_47CFAA
Lactobacillus jensenii, Strain EX849587VC06
Citrobacter sp., Strain 30_2
Staphylococcus warneri E4
Staphylococcus capitis A7
Bacteroides stercoris, Strain CC31F
Streptococcus sp., Strain CM7
Erysipelotrichaceae sp., Strain 6_1_45
Bacteroides fragilis, Strain CL05T00C42
Corynebacterium sp., Strain HFH0082
Propionibacterium acnes, Strain HL025PA2
Collinsella aerofaciens, Strain AAB3
Streptococcus sp., Strain BS29a
Prevotella veroralis, Oral Taxon 572, Strain F0319
Collinsella aerofaciens, Strain AAB3
Enterococcus faecium, Strain TX1330
Staphylococcus capitis B8
Enterococcus faecium, Strain TX1330
Prevotella bivia, Strain GED7760C
Escherichia coli, Strain MS 200-1
Prevotella disiens, Strain DNF00882
Staphylococcus epidermidis, Strain NIHLM031
Eubacterium sp., Strain AS15
Eubacterium infirmum, Strain F0142
Streptococcus salivarius, Strain SK126
Streptococcus sp., Strain BS21
Sporosarcina sp., Strain 2681
Lactobacillus jensenii, Strain 208-1
Staphylococcus aureus, Strain MN8
Enterococcus faecium, Strain TX1330
Streptococcus parasanguinis, Strain F0449
Sporosarcina sp., Strain 2681
Megasphaera sp., Strain DNF00912
Enterococcus faecalis, Strain TX2137
Streptococcus sp., Strain AS20
Streptococcus sp., Strain SR4
Blautia sp., Strain AAB30
Staphylococcus epidermidis, Strain NIH04008
Micrococcus luteus, Strain SK58
Sporosarcina sp., Strain 2681
Lactobacillus jensenii, Strain EX849587VC03
Lactobacillus jensenii, Strain EX849587VC06
Blautia sp., Strain AAB30
Staphylococcus capitis B12
Staphylococcus capitis A7
Staphylococcus capitis E7
Finegoldia magna, Strain SY01
Ruminococcus gnavus, Strain NWP325
Staphylococcus capitis C4
Staphylococcus warneri E4
Corynebacterium amycolatum, Strain SK46
Propionibacterium acnes, Strain HL050PA1
Escherichia coli, Strain MS 16-3
Lachnospiraceae bacterium, Strain AAB23
Prevotella nigrescens, Strain F0103
Escherichia coli, Strain MS 16-3
Staphylococcus haemolytics, Strain DNF00585
Lactobacillus jensenii, Strain EX849587VC06
Arthrobacter albus, Strain DNF00011
Eubacterium sp., Strain 3_1_31
Staphylococcus warneri C2
Collinsella sp., Strain 4_8_47FAA
Lactobacillus jensenii, Strain EX849587VC03
Rothia aeria, Oral Taxon 188, Strain F0474
Staphylococcus saprophyticus G1
Enterococcus faecium, Strain ERV102
Citrobacter freundii, Strain 4_7_47CFAA
Escherichia coli, Strain MS 200-1
Fusobacterium nucleatum, Strain CTI-05
Corynebacterium sp., Strain HFH0082
Fusobacterium sp., Oral Taxon 370, Strain F0437
Fusobacterium nucleatum, Strain CTI-05
Enterococcus faecium, Strain E417
Staphylococcus warneri, Strain SK66
Staphylococcus capitis B12
Bacteroides sp., Strain 4_1_36
Streptococcus sobrinus, Strain W1703
Fusobacterium sp., Strain CM21
Staphylococcus haemolyticus B6
Bacteroides stercoris, Strain CC31F
Bacteroides fragilis, Strain 3_1_12
Erysipelotrichaceae sp., Strain 6_1_45
Corynebacterium sp., Strain HFH0082
Escherichia coli, Strain MS 69-1
Lactobacillus gasseri, Strain JV-V03
Staphylococcus capitis A7
Escherichia coli, Strain 83972
Weissella cibaria, Strain F16_1
Escherichia sp., Strain 3_2_53FAA
Lactobacillus jensenii, Strain 208-1
Escherichia coli, Strain MS 115-1
Staphylococcus capitis A7
Sporosarcina sp., Strain 2681
Enterococcus faecium, Strain E417
Erysipelotrichaceae sp., Strain 6_1_45
Escherichia coli, Strain MS 115-1
Prevotella melaninogenica, Strain D18
Staphylococcus intermedius F7
Bacteroides stercoris, Strain CC31F
Corynebacterium amycolatum, Strain SK46
Staphylococcus hominis B3
Streptococcus sp., Strain OBRC6
Lactobacillus jensenii, Strain 208-1
Propionibacterium acnes, Strain HL059PA1
Streptococcus sp., Strain OBRC6
Streptococcus mitis, Strain F0392
Enterococcus faecalis, Strain TX2137
Escherichia sp., Strain 3_2_53FAA
Staphylococcus capitis A7
Lachnospiraceae bacterium, Strain AAB23
Enterococcus faecalis, Strain TUSoD Ef11
Bacteroides sp., Strain D2
Staphylococcus pasteuri C9
Enterococcus faecium, Strain ERV102
Fusobacterium nucleatum, Strain CTI-07
Bacteroides sp., Strain 4_1_36
Lactobacillus gasseri, Strain JV-V03
Corynebacterium amycolatum, Strain SK46
Staphylococcus capitis, Strain SK14
Proteus mirabilis, Strain WGLW6
Escherichia coli, Strain MS 110-3
Citrobacter freundii, Strain 4_7_47CFAA
Staphylococcus warneri D11
Fusobacterium sp., Strain CM21
Staphylococcus warneri E6
Staphylococcus epidermidis B11
Staphylococcus capitis E12
Staphylococcus cohnii G11
Staphylococcus aureus, Strain CM05
Bifidobacterium longum subsp. longum, Strain 44B
Streptococcus mitis, Strain F0392
Staphylococcus capitis C11
Escherichia coli, Strain MS 110-3
Escherichia coli, Strain MS 85-1
Bacteroidales bacterium, Strain KA00344
Enterococcus faecium, Strain ERV165
Staphylococcus pasteuri C9
Peptoniphilus sp., Oral Taxon 836, Strain F0141
Enterococcus faecalis, Strain S613
Shigella sp., Strain D9
Bacteroides sp., Strain D2
Enterococcus faecium, Strain E417
Staphylococcus saprophyticus E2
Escherichia coli, Strain MS 16-3
Citrobacter freundii, Strain 4_7_47CFAA
Enterococcus faecium, Strain TX1330
Sporosarcina sp., Strain 2681
Staphylococcus epidermidis, Strain NIH04008
Staphylococcus warneri E6
Staphylococcus cohnii G11
Escherichia coli, Strain MS 69-1
Staphylococcus epidermidis, Strain M23864:W2
Staphylococcus pasteuri E1
Staphylococcus pasteuri C9
Citrobacter freundii, Strain 4_7_47CFAA
Staphylococcus pasteuri C9
Arthrobacter albus, Strain DNF00011
Prevotella nigrescens, Strain F0103
Propionibacterium acnes, Strain HL037PA2
Enterococcus faecium, Strain TX1330
Propionibacterium acnes, Strain SK182
Bacteroides sp., Strain D2
Lactobacillus parafarraginis, Strain F0439
Micrococcus luteus, Strain SK58
Corynebacterium amycolatum, Strain SK46
Staphylococcus warneri E6
Klebsiella oxytoca, Strain MIT 09-7231
Megasphaera micronuciformis, Strain DNF00954
Staphylococcus capitis E12
Escherichia coli, Strain MS 196-1
Staphylococcus capitis B12
Fusobacterium sp., Strain CM22
Fusobacterium sp., Strain CM21
Peptoniphilus sp., Strain CMW7756A
Fusobacterium nucleatum subsp. animalis, Oral Taxon 420, Strain F0419
Lactobacillus parafarraginis, Strain F0439
Staphylococcus saprophyticus E8
Enterococcus faecium, Strain TX1330
Staphylococcus warneri B9
Staphylococcus warneri, Strain SK66
Klebsiella oxytoca, Strain MIT 10-5242
Streptococcus salivarius, Strain SK126
Peptoniphilus sp., Oral Taxon 836, Strain F0141
Blautia sp., Strain AAB30
Klebsiella pneumoniae subsp. pneumoniae, Strain WGLW1
Escherichia coli, Strain MS 85-1
Eubacterium sp., Strain AS15
Propionibacterium acnes, Strain HL030PA2
Staphylococcus aureus, Strain TCH70
Streptococcus sp., Strain CM7
Staphylococcus warneri E4
Propionibacterium acnes, Strain HL037PA1
Bacteroides fragilis, Strain 3_1_12
Escherichia coli, Strain MS 200-1
Citrobacter freundii, Strain 4_7_47CFAA
Ruminococcus gnavus, Strain NWP326
Prevotella disiens, Strain DNF00882
Lactobacillus crispatus, Strain JV-V01
Enterococcus faecium, Strain TX1330
Lactobacillus parafarraginis, Strain F0439
Propionibacterium acnes, Strain HL005PA4
Staphylococcus warneri E6
Arthrobacter albus, Strain DNF00011
Staphylococcus saprophyticus E2
Staphylococcus capitis B8
Propionibacterium propionicum, Oral Taxon 739, Strain F0230
Staphylococcus cohnii G11
Lactobacillus gasseri, Strain EX33690VC16
Klebsiella pneumoniae subsp. pneumoniae, Strain WGLW3
Lactobacillus gasseri, Strain JV-V03
Lactobacillus jensenii, Strain 208-1
Micrococcus luteus, Strain SK58
Fusobacterium sp., Oral Taxon 370, Strain F0437
Fusobacterium nucleatum, Strain CTI-07
Streptococcus sp., Strain ACS2
Enterococcus faecium, Strain ERV165
Streptococcus salivarius, Strain SK126
Enterococcus faecium, Strain TX1330
Capnocytophaga sp., Oral Taxon 336, Strain F0502
Staphylococcus saprophyticus D6
Blautia sp., Strain KLE 1732
Staphylococcus capitis E7
Escherichia sp., Strain 3_2_53FAA
Staphylococcus epidermidis, Strain NIHLM001
Micrococcus luteus, Strain SK58
Streptococcus gallolyticus subsp. gallolyticus, Strain TX20005
Catabacter hongkongensis, Strain AB8_9
Prevotella histicola, Strain F0411
Propionibacterium acnes, Strain HL059PA1
Corynebacterium sp., Strain HFH0082
Blautia sp., Strain KLE 1732
Staphylococcus capitis B12
Eggerthella sp., Strain MVA1
Streptococcus sp., Strain AS20
Staphylococcus capitis B12
Staphylococcus epidermidis, Strain NIHLM001
Propionibacterium acnes, Strain HL013PA2
Streptococcus gallolyticus subsp. gallolyticus, Strain TX20005
Staphylococcus caprae, Strain C87
Micrococcus luteus, Strain SK58
Staphylococcus aureus, Strain MN8
Staphylococcus warneri D11
Bacteroides sp., Strain 1_1_30
Staphylococcus capitis E12
Clostridium difficile, Strain 002-P50-2011
Streptococcus sp., Strain ACC21
Escherichia coli, Strain MS 200-1
Staphylococcus warneri D11
Streptococcus mitis, Strain F0392
Collinsella aerofaciens, Strain AAB3
Dorea sp., Strain AAB35
Shigella sp., Strain D9
Enterococcus faecium, Strain ERV102
Staphylococcus capitis A7
Enterococcus faecium, Strain ERV165
Lactobacillus jensenii, Strain 269-3
Staphylococcus warneri E4
Klebsiella pneumoniae subsp. pneumoniae, Strain WGLW1
Staphylococcus warneri E4
Enterococcus faecium, Strain TX1330
Streptococcus sp., Strain BS21
Escherichia coli, Strain MS 145-7
Klebsiella oxytoca, Strain MIT 10-5249
Streptococcus anginosus, Strain F0211
Erysipelotrichaceae sp., Strain 6_1_45
Enterococcus faecalis, Strain R712
Staphylococcus pasteuri E1
Klebsiella oxytoca, Strain MIT 10-5246
Staphylococcus pasteuri F12
Proteus mirabilis, Strain WGLW6
Staphylococcus warneri D11
Klebsiella pneumoniae subsp. pneumoniae, Strain WGLW3
Propionibacterium acnes, Strain HL050PA1
Streptococcus sp., Strain BS29a
Escherichia coli, Strain MS 145-7
Eubacterium infirmum, Strain F0142
Staphylococcus epidermidis, Strain E13A
Enterococcus faecium, Strain E417
Escherichia coli, Strain MS 16-3
Staphylococcus saprophyticus D10
Sporosarcina sp., Strain 2681
Staphylococcus saprophyticus E8
Fusobacterium sp., Strain CM22
Lachnospiraceae sp., Strain DNF00160
Fusobacterium sp., Oral Taxon 370, Strain F0437
Staphylococcus warneri E6
Bacteroides sp., Strain D2
Enterococcus faecium, Strain ERV102
Staphylococcus warneri D11
Staphylococcus capitis B8
Staphylococcus epidermidis H4
Staphylococcus epidermidis, Strain NIHLM003
Streptococcus cristatus, Strain F0329
Paenisporosarcina sp., Strain HGH0030
Fusobacterium periodonticum, Strain 1_A_54/D10
Proteus mirabilis, Strain WGLW6
Escherichia sp., Strain 3_2_53FAA
Corynebacterium sp., Strain HFH0082
Streptococcus salivarius, Strain SK126
Collinsella aerofaciens, Strain AAB3
Escherichia coli, Strain MS 110-3
Blautia sp., Strain AAB32
Escherichia coli, Strain MS 200-1
Fusobacterium nucleatum subsp. animalis, Oral Taxon 420, Strain F0419
Staphylococcus aureus, Strain TCH70
Staphylococcus epidermidis G10
Bacteroides stercoris, Strain CC31F
Propionibacterium acnes, Strain HL056PA1
Shuttleworthia sp., Strain MSX8B
Propionibacterium acnes, Strain HL027PA1
Collinsella aerofaciens, Strain AAB3
Erysipelotrichaceae sp., Strain 6_1_45
Bacteroides sp., Strain D2
Staphylococcus warneri E4
Staphylococcus capitis E7
Enterococcus faecium, Strain ERV165
Escherichia coli, Strain MS 110-3
Staphylococcus warneri B9
Prevotella bivia, Strain GED7760C
Lachnospiraceae bacterium, Strain AAB19
Enterococcus faecium, Strain ERV102
Propionibacterium acnes, Strain HL005PA4
Escherichia coli, Strain MS 16-3
Escherichia coli, Strain MS 110-3
Prevotella sp., Oral Taxon 317, Strain F0108
Propionibacterium acnes, Strain HL059PA1
Propionibacterium acnes, Strain HL005PA1
Lactobacillus crispatus, Strain JV-V01
Enterococcus faecium, Strain ERV102
Dorea formicigenerans, Strain AAB36
Escherichia coli, Strain MS 200-1
Escherichia coli, Strain MS 16-3
Fusobacterium nucleatum, Strain CTI-07
Staphylococcus epidermidis, Strain NIHLM020
Staphylococcus pasteuri G3
Streptococcus sobrinus, Strain W1703
Staphylococcus pasteuri G7
Escherichia coli, Strain 83972
Escherichia coli, Strain MS 69-1
Proteus mirabilis, Strain WGLW6
Rothia mucilaginosa, Strain CC87LB
Escherichia coli, Strain MS 200-1
Streptococcus sp., Strain BS29a
Lactobacillus jensenii, Strain EX849587VC06
Staphylococcus warneri B9
Enterococcus faecium, Strain ERV102
Corynebacterium sp., Strain HFH0082
Clostridiales bacterium, Strain 3_1_39B/D5
Klebsiella pneumoniae subsp. pneumoniae, Strain WGLW5
Escherichia coli, Strain MS 115-1
Lactobacillus jensenii, Strain 208-1
Staphylococcus warneri A11
Bacillus sp., Strain DNF00233
Streptococcus sp., Strain AS20
Lactobacillus crispatus, Strain 125-2-CHN
Staphylococcus warneri D9
Staphylococcus pasteuri C9
Proteus mirabilis, Strain WGLW6
Streptococcus gallolyticus subsp. gallolyticus, Strain TX20005
Veillonella sp., Oral Taxon 780, Strain F0422
Fusobacterium nucleatum, Strain CTI-05
Staphylococcus hominis C10
Staphylococcus epidermidis C3
Staphylococcus saprophyticus E8
Escherichia coli, Strain MS 115-1
Fusobacterium sp., Strain CM21
Prevotella buccae, Strain D17
Propionibacterium acnes, Strain HL046PA2
Staphylococcus pasteuri C9
Streptococcus sobrinus, Strain W1703
Staphylococcus warneri E6
Streptococcus downei, Oral Taxon 594, Strain F0415
Streptococcus mitis, Strain F0392
Staphylococcus warneri E4
Escherichia coli, Strain MS 115-1
Escherichia coli, Strain MS 196-1
Propionibacterium acnes, Strain HL002PA3
Staphylococcus warneri B9
Proteus mirabilis, Strain WGLW6
Arthrobacter albus, Strain DNF00011
Propionibacterium acnes, Strain HL043PA1
Corynebacterium sp., Strain HFH0082
Prevotella veroralis, Oral Taxon 572, Strain F0319
Corynebacterium amycolatum, Strain SK46
Klebsiella pneumoniae subsp. pneumoniae, Strain WGLW1
Staphylococcus warneri C5
Clostridium clostridioforme, Strain 2_1_49FAA
Hungatella hathewayi, Strain WAL-18680
Eubacterium sp., Strain 3_1_31
Peptoniphilus sp., Oral Taxon 836, Strain F0141
Staphylococcus capitis E12
Klebsiella oxytoca, Strain MIT 10-5250
Proteus mirabilis, Strain WGLW6
Lactobacillus gasseri, Strain JV-V03
Bacteroides stercoris, Strain CC31F
Propionibacterium acnes, Strain HL027PA2
Bacteroides stercoris, Strain CC31F
Propionibacterium acnes, Strain HL001PA1
Blautia sp., Strain AAB30
Streptococcus sp., Strain ACS2
Megasphaera micronuciformis, Strain DNF00954
Staphylococcus pasteuri F12
Streptococcus sp., Strain AS20
Fusobacterium periodonticum, Strain 1_A_54/D10
Streptococcus anginosus, Strain F0211
Proteus mirabilis, Strain WGLW6
Escherichia coli, Strain MS 85-1
Proteus mirabilis, Strain WGLW6
Staphylococcus capitis A7
Blautia sp., Strain AAB31
Staphylococcus epidermidis G10
Bacteroides stercoris, Strain CC31F
Staphylococcus pasteuri G3
Escherichia coli, Strain 83972
Klebsiella oxytoca, Strain MIT 10-5249
Staphylococcus aureus, Strain MN8
Staphylococcus warneri E6
Corynebacterium sp., Strain HFH0082
Escherichia coli, Strain MS 119-7
Fusobacterium nucleatum subsp. animalis, Oral Taxon 420, Strain F0419
Enterococcus faecium, Strain ERV102
Staphylococcus epidermidis, Strain NIHLM031
Staphylococcus capitis A7
Peptostreptococcus sp., Strain CC14N
Ruminococcus gnavus, Strain NWP326
Erysipelotrichaceae sp., Strain 6_1_45
Staphylococcus warneri D11
Bacteroides stercoris, Strain CC31F
Staphylococcus gallinarum E9
Staphylococcus pasteuri F11
Deinococcus grandis, Strain SK125
Streptococcus sp., Strain OBRC6
Propionibacterium acnes, Strain SK137
Escherichia coli, Strain 83972
Streptococcus parasanguinis, Strain F0449
Staphylococcus warneri, Strain SK66
Bacillus sp., Strain DNF00233
Fusobacterium nucleatum, Strain CTI-03
Oscillibacter sp., Strain KLE-1728
Staphylococcus warneri E6
Propionibacterium acnes, Strain HL045PA1
Staphylococcus capitis A7
Enterococcus faecium, Strain TX1330
Propionibacterium acnes, Strain HL007PA1
Fusobacterium sp., Strain CM21
Staphylococcus saprophyticus E8
Prevotella sp., Oral Taxon 472, Strain F0295
Propionibacterium acnes, Strain SK137
Escherichia coli, Strain 83972
Sporosarcina sp., Strain 2681
Corynebacterium sp., Strain HFH0082
Prevotella bivia, Strain GED7760C
Klebsiella sp., Strain MS 92-3
Lachnospiraceae sp., Strain DNF00160
Streptococcus parasanguinis, Strain F0449
Streptococcus sp., Strain C150
Staphylococcus capitis C4
Streptococcus salivarius, Strain SK126
Klebsiella oxytoca, Strain MIT 10-5249
Bacteroides stercoris, Strain CC31F
Streptococcus mitis, Strain F0392
Staphylococcus epidermidis, Strain NIHLM020
Staphylococcus capitis C4
Prevotella histicola, Strain F0411
Staphylococcus warneri B9
Micrococcus luteus, Strain SK58
Propionibacterium acnes, Strain HL050PA3
Bacillus sp., Strain DNF00233
Bacillus sp., Strain DNF00233
Staphylococcus aureus, Strain MN8
Escherichia coli, Strain MS 110-3
Fusobacterium nucleatum, Strain CTI-02
Blautia sp., Strain AAB30
Streptococcus mitis, Strain F0392
Staphylococcus lugdunensis F8
Staphylococcus warneri E6
Staphylococcus epidermidis, Strain NIH04008
Proteus mirabilis, Strain WGLW4
Prevotella histicola, Strain F0411
Bacteroides sp., Strain 4_1_36
Bacteroides eggerthii, Strain 1_2_48FAA
Staphylococcus capitis B8
Lactobacillus gasseri, Strain JV-V03
Staphylococcus warneri, Strain SK66
Staphylococcus capitis A7
Bacteroides sp., Strain D2
Sporosarcina sp., Strain 2681
Staphylococcus capitis C4
Staphylococcus hominis D2
Staphylococcus capitis A7
Escherichia coli, Strain MS 85-1
Staphylococcus warneri D11
Lactobacillus gasseri, Strain EX33690VC16
Lactobacillus jensenii, Strain EX849587VC03
Fusobacterium sp., Strain CM22
Lactobacillus jensenii, Strain 269-3
Staphylococcus pasteuri E5
Bacteroides sp., Strain AAB8
Staphylococcus warneri D4
Megasphaera sp., Strain DNF00912
Staphylococcus warneri E6
Staphylococcus pasteuri F11
Staphylococcus pasteuri F11
Lactobacillus parafarraginis, Strain F0439
Propionibacterium acnes, Strain HL060PA1
Lachnospiraceae sp., Strain ICM7
Prevotella disiens, Strain DNF00882
Lactobacillus crispatus, Strain JV-V01
Enterococcus faecalis, Strain S613
Propionibacterium acnes, Strain HL038PA1
Enterococcus faecium, Strain ERV99
Peptoniphilus sp., Oral Taxon 386, Strain F0131
Plesiomonas sp., Strain HPP0020
Staphylococcus warneri E6
Lactobacillus crispatus, Strain GED7749C
Escherichia sp., Strain 3_2_53FAA
Staphylococcus capitis A7
Bacteroides sp., Strain D2
Micrococcus luteus, Strain SK58
Bacteroides sp., Strain D2
Streptococcus sp., Strain ACS2
Propionibacterium acnes, Strain HL013PA2
Staphylococcus epidermidis D11
Citrobacter freundii, Strain 4_7_47CFAA
Enterococcus faecium, Strain ERV165
Peptoniphilus lacrimalis, Strain DNF00528
Propionibacterium acnes, Strain HL038PA1
Bacteroides sp., Strain D2
Clostridium orbiscindens, Strain CC43_001K
Staphylococcus aureus, Strain CM05
Prevotella sp., Oral Taxon 472, Strain F0295
Propionibacterium acnes, Strain HL013PA2
Fusobacterium nucleatum, Strain CTI-06
Fusobacterium nucleatum subsp. animalis, Oral Taxon 420, Strain F0419
Bacteroides sp., Strain D2
Streptococcus salivarius, Strain SK126
Staphylococcus haemolytics, Strain DNF00585
Lachnospiraceae bacterium, Strain AAB25
Staphylococcus pasteuri F12
Fusobacterium sp., Oral Taxon 370, Strain F0437
Fusobacterium periodonticum, Strain 2_1_31
Eggerthella sp., Strain MVA1
Staphylococcus aureus, Strain MN8
Staphylococcus warneri D11
Streptococcus anginosus, Strain F0211
Prevotella bivia, Strain GED7760C
Staphylococcus capitis A7
Streptococcus sp., Strain ACS2
Peptoniphilus sp., Oral Taxon 836, Strain F0141
Fusobacterium periodonticum, Strain 2_1_31
Staphylococcus warneri D4
Staphylococcus epidermidis, Strain NIHLM018
Escherichia coli, Strain MS 110-3
Staphylococcus hominis, Strain C80
Staphylococcus warneri, Strain SK66
Streptococcus parasanguinis, Strain F0449
Propionibacterium acnes, Strain HL078PA1
Proteus mirabilis, Strain WGLW6
Corynebacterium amycolatum, Strain SK46
Corynebacterium sp., Strain HFH0082
Streptococcus sp., Strain OBRC6
Streptococcus anginosus, Strain F0211
Staphylococcus aureus, Strain MN8
Lactobacillus jensenii, Strain 208-1
Fusobacterium sp., Strain CM22
Escherichia coli, Strain MS 16-3
Staphylococcus hominis B3
Staphylococcus warneri C5
Fusobacterium nucleatum, Strain CTI-02
Streptococcus sp., Strain SR4
Staphylococcus warneri B9
Streptococcus sp., Strain C150
Staphylococcus pasteuri E5
Citrobacter sp., Strain 30_2
Staphylococcus capitis B12
Corynebacterium amycolatum, Strain SK46
Hungatella hathewayi, Strain WAL-18680
Enterococcus faecium, Strain TX0133a04
Propionibacterium acnes, Strain HL053PA2
Streptococcus salivarius, Strain SK126
Propionibacterium acnes, Strain HL053PA1
Sporosarcina sp., Strain 2681
Streptococcus parasanguinis, Strain F0449
Escherichia coli, Strain MS 16-3
Staphylococcus capitis E7
Klebsiella pneumoniae subsp. pneumoniae, Strain WGLW3
Streptococcus parasanguinis, Strain F0449
Allobaculum sp., Strain NWP324
Fusobacterium periodonticum, Strain 2_1_31
Escherichia coli, Strain MS 110-3
Clostridium cadaveris, Strain CC44_001G
Staphylococcus pasteuri G7
Staphylococcus warneri B9
Propionibacterium acnes, Strain HL036PA1
Streptococcus sp., Strain OBRC6
Propionibacterium acnes, Strain HL036PA2
Klebsiella pneumoniae subsp. pneumoniae, Strain WGLW1
Collinsella sp., Strain 4_8_47FAA
Propionibacterium acnes, Strain HL025PA1
Catabacter hongkongensis, Strain AB8_9
Prevotella disiens, Strain DNF00882
Staphylococcus saprophyticus E8
Corynebacterium sp., Strain CMW7794
Coprococcus sp., Strain AAb34
Staphylococcus warneri C2
Staphylococcus warneri, Strain SK66
Streptococcus gallolyticus subsp. gallolyticus, Strain TX20005
Bacteroides sp., Strain 2_1_16
Staphylococcus pasteuri E1
Staphylococcus xylosus F2
Staphylococcus cohnii G11
Staphylococcus epidermidis, Strain NIH04008
Proteus mirabilis, Strain WGLW6
Lactobacillus gasseri, Strain EX33690VC16
Staphylococcus capitis B8
Staphylococcus capitis E7
Shigella sp., Strain D9
Pseudomonas sp., Strain HPB0071
Staphylococcus capitis B1
Proteus mirabilis, Strain WGLW4
Staphylococcus saprophyticus D10
Clostridium sp., Strain MSTE9
Streptococcus sp., Strain SR1
Eubacterium sp., Strain 3_1_31
Propionibacterium acnes, Strain HL005PA2
Rhodococcus erythropolis, Strain SK121
Staphylococcus epidermidis, Strain NIH04008
Micrococcus luteus, Strain SK58
Streptococcus sp., Strain AS20
Veillonella sp., Oral Taxon 780, Strain F0422
Bacteroides sp., Strain 2_1_16
Streptococcus sp., Strain ACS2
Fusobacterium sp., Strain CM22
Escherichia coli, Strain MS 145-7
Propionibacterium acnes, Strain HL027PA1
Staphylococcus pasteuri F11
Clostridium difficile, Strain 70-100-2010
Escherichia coli, Strain MS 69-1
Sporosarcina sp., Strain 2681
Streptococcus anginosus, Strain F0211
Weissella cibaria, Strain F16_1
Staphylococcus warneri B9
Staphylococcus warneri, Strain SK66
Staphylococcus capitis A7
Lactobacillus crispatus, Strain GED7749C
Streptococcus mitis, Strain F0392
Staphylococcus epidermidis, Strain NIH04008
Staphylococcus aureus, Strain TCH70
Staphylococcus capitis A7
Enterococcus faecium, Strain TX0133a04
Escherichia coli, Strain MS 196-1
Streptococcus parasanguinis, Strain F0449
Rothia mucilaginosa, Strain CC87LB
Streptococcus gallolyticus subsp. gallolyticus, Strain TX20005
Proteus mirabilis, Strain WGLW6
Staphylococcus capitis A7
Bacteroides stercoris, Strain CC31F
Staphylococcus capitis A7
Klebsiella pneumoniae subsp. pneumoniae, Strain WGLW1
Lachnospiraceae bacterium, Strain AAB23
Staphylococcus hominis C10
Megasphaera sp., Strain DNF00912
Staphylococcus capitis B8
Fusobacterium nucleatum subsp. animalis, Oral Taxon 420, Strain F0419
Escherichia coli, Strain MS 110-3
Escherichia sp., Strain 3_2_53FAA
Eggerthella sp., Strain MVA1
Enterococcus faecium, Strain ERV165
Staphylococcus saprophyticus D1
Staphylococcus pasteuri G3
Fusobacterium nucleatum, Strain MJR7757B
Staphylococcus epidermidis H11
Lactobacillus jensenii, Strain 269-3
Staphylococcus warneri B9
Klebsiella oxytoca, Strain MIT 10-5246
Lactobacillus gasseri, Strain 224-1
Enterococcus faecium, Strain TX1330
Staphylococcus pasteuri E5
Streptococcus intermedius, Strain F0413
Staphylococcus haemolyticus B6
Enterococcus faecalis, Strain TX2137
Staphylococcus capitis B8
Corynebacterium sp., Strain HFH0082
Staphylococcus capitis C4
Fusobacterium nucleatum, Strain CTI-05
Streptococcus mitis, Strain F0392
Escherichia coli, Strain MS 145-7
Lactobacillus jensenii, Strain 269-3
Corynebacterium amycolatum, Strain SK46
Prevotella bivia, Strain DNF00650
Staphylococcus warneri, Strain SK66
Streptococcus salivarius, Strain SK126
Staphylococcus warneri D11
Lactobacillus jensenii, Strain 208-1
Fusobacterium sp., Strain CM22
Propionibacterium acnes, Strain HL005PA3
Staphylococcus epidermidis, Strain NIHLM070
Propionibacterium acnes, Strain HL060PA1
Staphylococcus saprophyticus D6
Micrococcus luteus, Strain SK58
Staphylococcus pasteuri E1
Staphylococcus aureus, Strain CM05
Fusobacterium nucleatum subsp. animalis, Oral Taxon 420, Strain F0419
Sporosarcina sp., Strain 2681
Staphylococcus capitis A7
Streptococcus sp., Strain ACS2
Corynebacterium sp., Strain CMW7794
Escherichia coli, Strain MS 85-1
Blautia sp., Strain AAB30
Prevotella sp., Oral Taxon 317, Strain F0108
Clostridium perfringens, Strain WAL-14572
Clostridium aldenense, Strain WAL-18727
Staphylococcus warneri, Strain SK66
Enterococcus faecium, Strain TX0133a04
Klebsiella oxytoca, Strain MIT 10-5242
Lactobacillus crispatus, Strain 125-2-CHN
Enterococcus faecium, Strain TX1330
Lactobacillus jensenii, Strain EX849587VC06
Streptococcus sp., Strain AS20
Sporosarcina sp., Strain 2681
Corynebacterium amycolatum, Strain SK46
Escherichia coli, Strain 83972
Streptococcus gallolyticus subsp. gallolyticus, Strain TX20005
Bacteroides eggerthii, Strain 1_2_48FAA
Bacteroides dorei, Strain 5_1_36/D4
Prevotella sp., Oral Taxon 472, Strain F0295
Staphylococcus capitis E7
Staphylococcus warneri E6
Prevotella bivia, Strain DNF00188
Staphylococcus warneri B9
Escherichia coli, Strain MS 145-7
Clostridiales bacterium, Strain 4_1_37FAA
Lactobacillus crispatus, Strain MV-3A-US
Enterococcus faecium, Strain ERV102
Bacteroides fragilis, Strain CL07T12C05
Bacteroides sp., Strain D2
Fusobacterium nucleatum subsp. animalis, Oral Taxon 420, Strain F0419
Prevotella sp., Oral Taxon 472, Strain F0295
Staphylococcus epidermidis, Strain NIHLM008
Citrobacter sp., Strain 30_2
Staphylococcus capitis B8
Ruminococcus gnavus, Strain AAB28
Shigella sp., Strain D9
Plesiomonas sp., Strain HPP0020
Staphylococcus capitis E7
Propionibacterium propionicum, Oral Taxon 739, Strain F0230
Eubacterium infirmum, Strain F0142
Staphylococcus warneri F1
Streptococcus cristatus, Strain F0329
Bacteroides sp., Strain AAB8
Parabacteroides sp., Strain D13
Staphylococcus epidermidis C3
Sporosarcina sp., Strain 2681
Shigella sp., Strain D9
Clostridiales bacterium, Strain 4_1_37FAA
Propionibacterium acnes, Strain HL025PA2
Escherichia coli, Strain MS 145-7
Proteus mirabilis, Strain WGLW6
Staphylococcus pasteuri C9
Sporosarcina sp., Strain 2681
Staphylococcus capitis E11
Streptococcus sp., Strain BS29a
Propionibacterium acnes, Strain HL007PA1
Staphylococcus epidermidis, Strain NIHLM040
Corynebacterium sp., Strain CMW7794
Staphylococcus warneri E4
Propionibacterium acnes, Strain HL025PA1
Klebsiella pneumoniae subsp. pneumoniae, Strain WGLW1
Staphylococcus saprophyticus E8
Klebsiella sp., Strain MS 92-3
Streptococcus sp., Strain OBRC6
Fusobacterium periodonticum, Strain 1_A_54/D10
Staphylococcus cohnii G11
Prevotella bivia, Strain DNF00650
Streptococcus salivarius, Strain SK126
Staphylococcus intermedius F7
Lactobacillus crispatus, Strain JV-V01
Enterococcus faecalis, Strain S613
Staphylococcus hominis B3
Enterococcus faecium, Strain E417
Corynebacterium amycolatum, Strain SK46
Arthrobacter albus, Strain DNF00011
Propionibacterium acnes, Strain HL037PA2
Propionibacterium acnes, Strain HL056PA1
Fusobacterium sp., Strain CM22
Peptostreptococcus sp., Strain CC14N
Klebsiella oxytoca, Strain MIT 10-5246
Prevotella bivia, Strain DNF00188
Prevotella bivia, Strain DNF00650
Prevotella timonensis, Strain CRIS 5C-B1
Escherichia coli, Strain MS 196-1
Staphylococcus epidermidis F6
Escherichia coli, Strain 83972
Propionibacterium acnes, Strain HL027PA1
Escherichia coli, Strain MS 110-3
Streptococcus mitis, Strain F0392
Blautia sp., Strain KLE 1732
Lactobacillus jensenii, Strain EX849587VC06
Collinsella aerofaciens, Strain AAB3
Clostridium orbiscindens, Strain CC43_001K
Erysipelotrichaceae sp., Strain 6_1_45
Streptococcus sp., Strain C150
Fusobacterium nucleatum, Strain CTI-07
Staphylococcus warneri C2
Deinococcus grandis, Strain SK125
Staphylococcus pasteuri G3
Shigella sp., Strain D9
Streptococcus salivarius, Strain SK126
Staphylococcus warneri B9
Corynebacterium sp., Strain HFH0082
Staphylococcus pasteuri F12
Clostridium cadaveris, Strain CC44_001G
Staphylococcus capitis C12
Streptococcus sobrinus, Strain W1703
Proteus mirabilis, Strain WGLW4
Corynebacterium sp., Strain CMW7794
Staphylococcus caprae, Strain C87
Dermabacter sp., Strain HFH0086
Enterococcus faecium, Strain E417
Staphylococcus epidermidis F6
Fusobacterium nucleatum, Strain CTI-07
Erysipelotrichaceae sp., Strain 6_1_45
Proteus mirabilis, Strain WGLW6
Klebsiella oxytoca, Strain MIT 10-5246
Corynebacterium sp., Strain HFH0082
Lactobacillus jensenii, Strain EX849587VC06
Lactobacillus jensenii, Strain 208-1
Escherichia coli, Strain MS 110-3
Streptococcus sp., Strain AS20
Clostridium bolteae, Strain CC43_001B
Lactobacillus jensenii, Strain EX849587VC03
Citrobacter sp., Strain 30_2
Eggerthella sp., Strain MVA1
Staphylococcus warneri E4
Enterococcus faecium, Strain TX0133a04
Propionibacterium acnes, Strain HL053PA2
Klebsiella oxytoca, Strain MIT 10-5246
Blautia sp., Strain KLE 1732
Prevotella denticola, Strain DNF00960
Fusobacterium nucleatum, Strain CTI-05
Staphylococcus warneri D11
Rhodococcus erythropolis, Strain SK121
Enterococcus faecium, Strain ERV165
Veillonella sp., Oral Taxon 780, Strain F0422
Proteus mirabilis, Strain WGLW4
Anaerostipes sp., Strain 3_2_56FAA
Blautia sp., Strain AAB30
Corynebacterium amycolatum, Strain SK46
Staphylococcus pasteuri F12
Escherichia coli, Strain MS 145-7
Staphylococcus haemolyticus G2
Staphylococcus epidermidis, Strain NIHLM067
Staphylococcus warneri E6
Enterococcus faecalis, Strain TX2137
Fusobacterium sp., Strain CM22
Streptococcus sp., Strain SR1
Prevotella disiens, Strain DNF00882
Fusobacterium sp., Strain CM21
Enterococcus faecalis, Strain R712
Fusobacterium sp., Strain CM22
Staphylococcus pasteuri G3
Fusobacterium sp., Oral Taxon 370, Strain F0437
Staphylococcus epidermidis, Strain NIHLM015
Lactobacillus jensenii, Strain 208-1
Escherichia coli, Strain MS 145-7
Enterococcus faecium, Strain ERV165
Bacteroidales bacterium, Strain KA00344
Staphylococcus warneri E6
Escherichia coli, Strain MS 200-1
Klebsiella oxytoca, Strain MIT 10-5245
Klebsiella oxytoca, Strain MIT 10-5245
Prevotella bivia, Strain DNF00650
Klebsiella oxytoca, Strain MIT 10-5249
Proteus mirabilis, Strain WGLW6
Escherichia coli, Strain 83972
Staphylococcus pasteuri F12
Lactobacillus gasseri, Strain JV-V03
Staphylococcus capitis A7
Escherichia coli, Strain 83972
Catabacter hongkongensis, Strain AB8_9
Staphylococcus epidermidis, Strain NIHLM015
Propionibacterium acnes, Strain HL045PA1
Lactobacillus crispatus, Strain JV-V01
Staphylococcus warneri B9
Staphylococcus aureus, Strain TCH70
Propionibacterium acnes, Strain HL037PA1
Proteus mirabilis, Strain WGLW6
Lactobacillus jensenii, Strain EX849587VC06
Shuttleworthia sp., Strain MSX8B
Bacteroides fragilis, Strain CL07T12C05
Staphylococcus aureus, Strain CM05
Plesiomonas sp., Strain HPP0020
Citrobacter sp., Strain 30_2
Fusobacterium sp., Oral Taxon 370, Strain F0437
Staphylococcus capitis E7
Enterococcus faecium, Strain TX1330
Propionibacterium acnes, Strain HL043PA2
Parabacteroides merdae, Strain CL09T00C40
Propionibacterium acnes, Strain HL030PA2
Staphylococcus pasteuri F11
Streptococcus sp., Strain BS21
Lactobacillus parafarraginis, Strain F0439
Staphylococcus aureus, Strain CM05
Escherichia coli, Strain MS 115-1
Actinomyces neuii, Strain MJR8396A
Actinomyces neuii, Strain MJR8396A
Klebsiella oxytoca, Strain MIT 10-5249
Proteus mirabilis, Strain WGLW4
Propionibacterium acnes, Strain HL013PA2
Lactobacillus parafarraginis, Strain F0439
Proteus mirabilis, Strain WGLW6
Staphylococcus warneri B9
Streptococcus mitis, Strain F0392
Lactobacillus gasseri, Strain SV-16A-US
Staphylococcus warneri D4
Propionibacterium acnes, Strain HL001PA1
Klebsiella oxytoca, Strain MIT 10-5248
Propionibacterium acnes, Strain HL002PA2
Fusobacterium periodonticum, Strain 1_A_54/D10
Bacteroides stercoris, Strain CC31F
Citrobacter freundii, Strain 4_7_47CFAA
Streptococcus sp., Strain ACC21
Propionibacterium sp., Strain 5_U_42AFAA
Escherichia coli, Strain MS 196-1
Coprococcus sp., Strain AAb34
Streptococcus gallolyticus subsp. gallolyticus, Strain TX20005
Propionibacterium acnes, Strain HL046PA2
Staphylococcus warneri B9
Bacteroides stercoris, Strain CC31F
Propionibacterium acnes, Strain HL060PA1
Propionibacterium acnes, Strain HL005PA2
Staphylococcus caprae, Strain C87
Escherichia coli, Strain MS 145-7
Klebsiella oxytoca, Strain MIT 10-5249
Escherichia coli, Strain MS 69-1
Staphylococcus warneri B9
Streptococcus sp., Strain ACS2
Prevotella disiens, Strain DNF00882
Klebsiella oxytoca, Strain MIT 10-5242
Citrobacter sp., Strain 30_2
Collinsella sp., Strain 4_8_47FAA
Staphylococcus epidermidis, Strain NIHLM031
Klebsiella pneumoniae subsp. pneumoniae, Strain WGLW3
Proteus mirabilis, Strain WGLW4
Streptococcus anginosus, Strain F0211
Escherichia coli, Strain MS 110-3
Enterococcus faecium, Strain TX1330
Erysipelotrichaceae sp., Strain 6_1_45
Klebsiella pneumoniae subsp. pneumoniae, Strain WGLW5
Lactobacillus jensenii, Strain EX849587VC06
Blautia sp., Strain AAB30
Staphylococcus epidermidis, Strain NIH05001
Fusobacterium nucleatum subsp. animalis, Oral Taxon 420, Strain F0419
Propionibacterium acnes, Strain HL013PA1
Lachnospiraceae bacterium, Strain AAB19
Staphylococcus warneri C5
Streptococcus sobrinus, Strain W1703
Escherichia coli, Strain MS 196-1
Fusobacterium sp., Strain CM22
Plesiomonas sp., Strain HPP0020
Staphylococcus capitis A10
Lachnospiraceae sp., Strain DNF00160
Escherichia coli, Strain 83972
Staphylococcus warneri B9
Escherichia coli, Strain MS 119-7
Fusobacterium sp., Strain CM22
Escherichia coli, Strain 83972
Propionibacterium acnes, Strain HL027PA2
Fusobacterium nucleatum subsp. animalis, Oral Taxon 420, Strain F0419
Propionibacterium acnes, Strain HL046PA2
Hungatella hathewayi, Strain WAL-18680
Parabacteroides merdae, Strain CL09T00C40
Fusobacterium sp., Strain CM22
Ruminococcus gnavus, Strain AAB28
Lactobacillus rhamnosus, Strain LMS2-1
Sporosarcina sp., Strain 2681
Staphylococcus pasteuri F12
Plesiomonas sp., Strain HPP0020
Staphylococcus pasteuri G7
Prevotella veroralis, Oral Taxon 572, Strain F0319
Staphylococcus capitis B1
Klebsiella pneumoniae subsp. pneumoniae, Strain WGLW2
Enterococcus faecalis, Strain TX2137
Citrobacter freundii, Strain 4_7_47CFAA
Staphylococcus aureus, Strain CM05
Enterococcus faecium, Strain TX1330
Collinsella sp., Strain 4_8_47FAA
Klebsiella pneumoniae subsp. pneumoniae, Strain WGLW2
Staphylococcus capitis A7
Clostridium aldenense, Strain WAL-18727
Staphylococcus pasteuri E5
Staphylococcus epidermidis, Strain NIHLM020
Enterococcus faecium, Strain TX0133a04
Staphylococcus warneri B9
Staphylococcus pasteuri C9
Escherichia coli, Strain 83972
Lactobacillus jensenii, Strain EX849587VC06
Propionibacterium acnes, Strain HL036PA1
Staphylococcus lugdunensis F8
Lactobacillus crispatus, Strain JV-V01
Streptococcus downei, Oral Taxon 594, Strain F0415
Enterococcus faecalis, Strain TX2137
Staphylococcus saprophyticus F6
Staphylococcus warneri D4
Staphylococcus hominis B3
Streptococcus sp., Strain OBRC6
Staphylococcus pasteuri F11
Prevotella bivia, Strain GED7760C
Shigella sp., Strain D9
Lactobacillus gasseri, Strain JV-V03
Corynebacterium sp., Strain HFH0082
Fusobacterium nucleatum, Strain CTI-07
Klebsiella oxytoca, Strain MIT 10-5249
Staphylococcus warneri B9
Staphylococcus capitis A7
Corynebacterium sp., Strain HFH0082
Corynebacterium amycolatum, Strain SK46
Lactobacillus jensenii, Strain 269-3
Bacteroides stercoris, Strain CC31F
Bifidobacterium breve, Strain HPH0326
Propionibacterium acnes, Strain HL045PA1
Staphylococcus epidermidis H6
Staphylococcus aureus, Strain TCH70
Klebsiella oxytoca, Strain MIT 10-5246
Staphylococcus epidermidis C3
Klebsiella sp., Strain 4_1_44FAA
Staphylococcus pasteuri F12
Propionibacterium acnes, Strain HL007PA1
Escherichia coli, Strain 83972
Staphylococcus capitis C4
Fusobacterium nucleatum subsp. animalis, Oral Taxon 420, Strain F0419
Staphylococcus warneri D3
Lachnospiraceae sp., Strain DNF00160
Staphylococcus epidermidis, Strain NIH04008
Staphylococcus warneri D11
Escherichia coli, Strain MS 110-3
Staphylococcus aureus, Strain MN8
Lactobacillus jensenii, Strain 269-3
Klebsiella pneumoniae subsp. pneumoniae, Strain WGLW1
Bacteroides fragilis, Strain CL07T12C05
Clostridium aldenense, Strain WAL-18727
Micrococcus luteus, Strain SK58
Proteus mirabilis, Strain WGLW6
Staphylococcus warneri E6
Staphylococcus pasteuri F12
Propionibacterium acnes, Strain HL027PA2
Fusobacterium nucleatum subsp. polymorphum, Strain F0401
Klebsiella pneumoniae subsp. pneumoniae, Strain WGLW1
Staphylococcus warneri D11
Staphylococcus epidermidis C6
Micrococcus luteus, Strain SK58
Fusobacterium nucleatum subsp. animalis, Oral Taxon 420, Strain F0419
Fusobacterium nucleatum, Strain CTI-07
Citrobacter freundii, Strain 4_7_47CFAA
Enterococcus faecalis, Strain TUSoD Ef11
Micrococcus luteus, Strain SK58
Staphylococcus haemolytics, Strain DNF00585
Staphylococcus warneri C2
Staphylococcus epidermidis, Strain NIH04008
Staphylococcus saprophyticus D6
Staphylococcus warneri E6
Streptococcus parasanguinis, Strain F0449
Klebsiella oxytoca, Strain MIT 09-7231
Eubacterium sp., Strain 3_1_31
Staphylococcus warneri E6
Citrobacter freundii, Strain 4_7_47CFAA
Bacteroides sp., Strain 1_1_30
Staphylococcus warneri E4
Propionibacterium acnes, Strain HL005PA1
Staphylococcus hominis, Strain C80
Citrobacter freundii, Strain 4_7_47CFAA
Streptococcus sp., Strain SR1
Pseudomonas sp., Strain HPB0071
Staphylococcus epidermidis, Strain W23144
Citrobacter sp., Strain 30_2
Bacteroides stercoris, Strain CC31F
Klebsiella oxytoca, Strain MIT 09-7231
Staphylococcus warneri A3
Enterococcus faecium, Strain TX1330
Streptococcus gallolyticus subsp. gallolyticus, Strain TX20005
Ruminococcus gnavus, Strain NWP327
Lactobacillus crispatus, Strain GED7749C
Bacteroides fragilis, Strain CL05T00C42
Staphylococcus capitis C4
Streptococcus sp., Strain SR1
Staphylococcus warneri C2
Escherichia coli, Strain MS 115-1
Fusobacterium nucleatum, Strain CTI-03
Citrobacter freundii, Strain 4_7_47CFAA
Enterococcus faecium, Strain TX1330
Proteus mirabilis, Strain WGLW6
Bacteroidales bacterium, Strain KA00344
Streptococcus sp., Strain AS20
Streptococcus cristatus, Strain F0329
Lactobacillus crispatus, Strain JV-V01
Fusobacterium nucleatum, Strain CTI-03
Enterococcus faecium, Strain ERV102
Streptococcus gallolyticus subsp. gallolyticus, Strain TX20005
Staphylococcus hominis, Strain C80
Citrobacter freundii, Strain 4_7_47CFAA
Enterococcus faecium, Strain ERV165
Fusobacterium nucleatum, Strain CTI-02
Fusobacterium sp., Strain CM22
Propionibacterium acnes, Strain HL036PA2
Escherichia sp., Strain 3_2_53FAA
Escherichia coli, Strain MS 85-1
Escherichia coli, Strain MS 69-1
Propionibacterium acnes, Strain HL013PA1
Bifidobacterium breve, Strain EX336960VC19
Enterococcus faecalis, Strain S613
Arthrobacter albus, Strain DNF00011
Propionibacterium acnes, Strain SK137
Deinococcus grandis, Strain SK125
Lachnospiraceae bacterium, Strain AAB23
Lactobacillus jensenii, Strain 269-3
Citrobacter sp., Strain 30_2
Catabacter hongkongensis, Strain AB8_9
Klebsiella pneumoniae subsp. pneumoniae, Strain WGLW5
Fusobacterium nucleatum, Strain CTI-06
Staphylococcus pasteuri E1
Lachnospiraceae bacterium, Strain AAB19
Staphylococcus pasteuri G7
Corynebacterium amycolatum, Strain SK46
Streptococcus sp., Strain C150
Fusobacterium nucleatum, Strain CTI-02
Klebsiella sp., Strain 1_1_55
Streptococcus downei, Oral Taxon 594, Strain F0415
Streptococcus sp., Strain AS20
Fusobacterium sp., Oral Taxon 370, Strain F0437
Proteus mirabilis, Strain WGLW6
Streptococcus sp., Strain AS20
Propionibacterium acnes, Strain HL060PA1
Sporosarcina sp., Strain 2681
Enterococcus faecium, Strain ERV102
Staphylococcus warneri D11
Escherichia coli, Strain MS 200-1
Fusobacterium nucleatum, Strain CTI-02
Streptococcus sp., Strain AS20
Collinsella aerofaciens, Strain AAB3
Bacteroides dorei, Strain 5_1_36/D4
Staphylococcus epidermidis H4
Megasphaera micronuciformis, Strain DNF00954
Lactobacillus gasseri, Strain JV-V03
Staphylococcus epidermidis, Strain NIHLM020
Streptococcus salivarius, Strain SK126
Propionibacterium acnes, Strain HL059PA1
Klebsiella oxytoca, Strain MIT 10-5246
Propionibacterium acnes, Strain HL002PA2
Staphylococcus epidermidis, Strain NIHLM001
Enterococcus faecalis, Strain TX2137
Prevotella bivia, Strain DNF00188
Propionibacterium acnes, Strain HL050PA1
Enterococcus faecium, Strain ERV99
Dermabacter sp., Strain HFH0086
Escherichia coli, Strain MS 196-1
Streptococcus sp., Strain SR1
Staphylococcus aureus, Strain MN8
Escherichia coli, Strain MS 145-7
Staphylococcus aureus, Strain CM05
Staphylococcus warneri D11
Staphylococcus epidermidis F6
Collinsella sp., Strain 4_8_47FAA
Staphylococcus pasteuri E5
Staphylococcus saprophyticus E8
Prevotella bivia, Strain GED7760C
Sporosarcina sp., Strain 2681
Propionibacterium acnes, Strain HL002PA3
Staphylococcus warneri C2
Propionibacterium acnes, Strain HL046PA2
Bacteroides stercoris, Strain CC31F
Dorea formicigenerans, Strain AAB36
Escherichia coli, Strain MS 69-1
Clostridium orbiscindens, Strain CC43_001K
Klebsiella pneumoniae subsp. pneumoniae, Strain WGLW3
Fusobacterium sp., Strain CM21
Streptococcus sp., Strain ACS2
Klebsiella pneumoniae subsp. pneumoniae, Strain WGLW5
Streptococcus intermedius, Strain F0413
Plesiomonas sp., Strain HPP0020
Rhodococcus erythropolis, Strain SK121
Clostridium cadaveris, Strain CC40_001C
Escherichia coli, Strain MS 200-1
Fusobacterium sp., Strain CM22
Fusobacterium periodonticum, Strain 1_A_54/D10
Klebsiella oxytoca, Strain MIT 09-7231
Prevotella sp., Oral Taxon 472, Strain F0295
Streptococcus sanguinis, Strain VMC66
Escherichia coli, Strain MS 145-7
Propionibacterium acnes, Strain HL043PA2
Lactobacillus crispatus, Strain GED7749C
Klebsiella sp., Strain 4_1_44FAA
Lactobacillus jensenii, Strain 269-3
Streptococcus mitis, Strain F0392
Staphylococcus warneri F1
Streptococcus sobrinus, Strain W1703
Plesiomonas sp., Strain HPP0020
Enterococcus faecium, Strain E417
Escherichia coli, Strain MS 115-1
Streptococcus sp., Strain CM7
Streptococcus cristatus, Strain F0329
Escherichia coli, Strain MS 115-1
Streptococcus sp., Strain ACC21
Klebsiella oxytoca, Strain MIT 10-5246
Megasphaera sp., Strain DNF00872
Lachnospiraceae bacterium, Strain AAB26
Klebsiella sp., Strain 1_1_55
Propionibacterium acnes, Strain HL027PA2
Lactobacillus jensenii, Strain EX849587VC03
Fusobacterium sp., Oral Taxon 370, Strain F0437
Veillonella sp., Oral Taxon 780, Strain F0422
Escherichia coli, Strain MS 85-1
Capnocytophaga sputigena, Strain CC21_001D
Streptococcus sp., Strain AS20
Oscillibacter sp., Strain KLE-1728
Blautia sp., Strain KLE 1732
Fusobacterium sp., Oral Taxon 370, Strain F0437
Escherichia coli, Strain MS 145-7
Staphylococcus hominis, Strain SK119
Corynebacterium sp., Strain CMW7794
Catabacter hongkongensis, Strain AB8_9
Staphylococcus warneri E4
Corynebacterium sp., Strain CMW7794
Propionibacterium acnes, Strain HL020PA1
Staphylococcus capitis C4
Allobaculum sp., Strain NWP324
Streptococcus mitis, Strain F0392
Streptococcus sp., Strain SR1
Propionibacterium acnes, Strain HL005PA1
Staphylococcus capitis C4
Fusobacterium periodonticum, Strain 2_1_31
Streptococcus anginosus, Strain F0211
Staphylococcus pasteuri G7
Prevotella buccae, Strain D17
Prevotella bivia, Strain DNF00188
Streptococcus anginosus, Strain F0211
Rothia mucilaginosa, Strain CC87LB
Staphylococcus warneri D11
Enterococcus faecium, Strain ERV165
Corynebacterium sp., Strain CMW7794
Staphylococcus xylosus F2
Staphylococcus epidermidis C3
Bacteroides stercoris, Strain CC31F
Staphylococcus haemolyticus G9
Klebsiella oxytoca, Strain MIT 10-5249
Escherichia coli, Strain MS 16-3
Staphylococcus gallinarum E9
Staphylococcus pasteuri F11
Staphylococcus pasteuri G3
Escherichia coli, Strain MS 115-1
Escherichia coli, Strain MS 57-2
Clostridiales bacterium, Strain 4_1_37FAA
Staphylococcus warneri D9
Corynebacterium amycolatum, Strain SK46
Streptococcus salivarius, Strain SK126
Enterococcus faecalis, Strain TUSoD Ef11
Propionibacterium acnes, Strain HL002PA2
Fusobacterium sp., Strain CM22
Megasphaera micronuciformis, Strain DNF00954
Fusobacterium nucleatum, Strain CTI-03
Enterococcus faecalis, Strain TX2137
Staphylococcus capitis E12
Streptococcus gallolyticus subsp. gallolyticus, Strain TX20005
Klebsiella pneumoniae subsp. pneumoniae, Strain WGLW2
Escherichia coli, Strain MS 110-3
Staphylococcus warneri B9
Streptococcus gallolyticus subsp. gallolyticus, Strain TX20005
Klebsiella oxytoca, Strain MIT 10-5249
Escherichia coli, Strain MS 85-1
Staphylococcus epidermidis, Strain NIH04008
Enterococcus faecium, Strain TX1330
Lactobacillus crispatus, Strain JV-V01
Staphylococcus capitis A7
Propionibacterium acnes, Strain HL001PA1
Escherichia coli, Strain MS 110-3
Lactobacillus crispatus, Strain JV-V01
Escherichia coli, Strain 83972
Bifidobacterium angulatum, Strain F16_22
Propionibacterium acnes, Strain HL036PA2
Erysipelotrichaceae sp., Strain 6_1_45
Dorea formicigenerans, Strain AAB36
Proteus mirabilis, Strain WGLW6
Propionibacterium acnes, Strain HL037PA2
Bacteroides fragilis, Strain 3_1_12
Corynebacterium sp., Strain HFH0082
Streptococcus sp., Strain OBRC6
Staphylococcus pasteuri E5
Propionibacterium acnes, Strain HL060PA1
Klebsiella oxytoca, Strain MIT 09-7231
Lactobacillus jensenii, Strain 269-3
Allobaculum sp., Strain NWP324
Fusobacterium sp., Strain CM22
Klebsiella oxytoca, Strain MIT 10-5243
Fusobacterium periodonticum, Strain 2_1_31
Staphylococcus capitis, Strain SK14
Enterococcus faecium, Strain ERV165
Klebsiella oxytoca, Strain MIT 10-5246
Streptococcus vestibularis, Strain F0396
Staphylococcus capitis A7
Enterococcus faecium, Strain TX0133a04
Megasphaera sp., Strain DNF00872
Dermabacter sp., Strain HFH0086
Prevotella buccae, Strain D17
Propionibacterium acnes, Strain HL060PA1
Bacillus sp., Strain DNF00233
Staphylococcus epidermidis, Strain NIHLM040
Enterococcus faecium, Strain TX1330
Rothia aeria, Oral Taxon 188, Strain F0474
Bacteroidales bacterium, Strain KA00344
Staphylococcus warneri, Strain SK66
Dorea formicigenerans, Strain AAB36
Enterococcus faecium, Strain E417
Staphylococcus warneri A8
Lactobacillus crispatus, Strain JV-V01
Streptococcus anginosus, Strain F0211
Bacillus sp., Strain DNF00233
Staphylococcus epidermidis, Strain NIHLM040
Escherichia coli, Strain MS 16-3
Fusobacterium nucleatum, Strain CTI-02
Streptococcus salivarius, Strain SK126
Staphylococcus capitis A5
Peptoniphilus lacrimalis, Strain UPII 315-B
Eggerthella sp., Strain MVA1
Corynebacterium sp., Strain HFH0082
Erysipelotrichaceae sp., Strain 6_1_45
Deinococcus grandis, Strain SK125
Erysipelotrichaceae sp., Strain 6_1_45
Klebsiella sp., Strain 4_1_44FAA
Propionibacterium acnes, Strain HL053PA1
Erysipelotrichaceae sp., Strain 6_1_45
Staphylococcus cohnii G11
Staphylococcus capitis C12
Fusobacterium nucleatum subsp. animalis, Strain D11
Staphylococcus epidermidis F6
Streptococcus mitis, Strain F0392
Bifidobacterium longum subsp. longum, Strain 44B
Fusobacterium nucleatum, Strain CTI-03
Hungatella hathewayi, Strain WAL-18680
Peptoniphilus lacrimalis, Strain DNF00528
Sporosarcina sp., Strain 2681
Klebsiella sp., Strain 1_1_55
Erysipelotrichaceae sp., Strain 6_1_45
Proteus mirabilis, Strain WGLW6
Fusobacterium sp., Strain CM21
Lactobacillus gasseri, Strain JV-V03
Corynebacterium sp., Strain HFH0082
Staphylococcus epidermidis H4
Propionibacterium acnes, Strain HL030PA2
Micrococcus luteus, Strain SK58
Streptococcus gallolyticus subsp. gallolyticus, Strain TX20005
Lactobacillus jensenii, Strain EX849587VC06
Klebsiella oxytoca, Strain MIT 10-5243
Fusobacterium nucleatum subsp. animalis, Oral Taxon 420, Strain F0419
Streptococcus parasanguinis, Strain F0449
Eubacterium infirmum, Strain F0142
Weissella cibaria, Strain F16_1
Staphylococcus capitis A7
Plesiomonas sp., Strain HPP0020
Propionibacterium acnes, Strain HL005PA1
Lactobacillus jensenii, Strain EX849587VC06
Staphylococcus warneri, Strain SK66
Klebsiella pneumoniae subsp. pneumoniae, Strain WGLW3
Micrococcus luteus, Strain SK58
Ruminococcus gnavus, Strain NWP326
Propionibacterium acnes, Strain HL013PA2
Escherichia coli, Strain MS 16-3
Propionibacterium acnes, Strain HL002PA3
Streptococcus salivarius, Strain SK126
Propionibacterium acnes, Strain HL030PA1
Fusobacterium sp., Strain CM22
Peptoniphilus sp., Oral Taxon 836, Strain F0141
Escherichia coli, Strain 83972
Staphylococcus capitis C11
Staphylococcus aureus, Strain TCH70
Enterococcus faecium, Strain E417
Bacillus sp., Strain DNF00233
Staphylococcus capitis A7
Lactobacillus gasseri, Strain EX33690VC16
Proteus mirabilis, Strain WGLW6
Streptococcus sp., Strain SR1
Streptococcus sobrinus, Strain W1703
Staphylococcus hominis B3
Bifidobacterium breve, Strain EX336960VC19
Proteus mirabilis, Strain WGLW4
Collinsella sp., Strain 4_8_47FAA
Klebsiella pneumoniae subsp. pneumoniae, Strain WGLW5
Streptococcus gallolyticus subsp. gallolyticus, Strain TX20005
Bacteroides stercoris, Strain CC31F
Escherichia sp., Strain 3_2_53FAA
Staphylococcus capitis A7
Enterococcus faecalis, Strain TX2137
Prevotella histicola, Strain F0411
Propionibacterium acnes, Strain HL002PA3
Staphylococcus hominis, Strain SK119
Staphylococcus aureus, Strain CM05
Enterococcus faecium, Strain ERV99
Staphylococcus haemolytics, Strain DNF00585
Fusobacterium sp., Strain CM22
Fusobacterium nucleatum, Strain CTI-03
Propionibacterium acnes, Strain HL036PA2
Enterococcus faecium, Strain ERV102
Propionibacterium acnes, Strain HL002PA2
Propionibacterium acnes, Strain HL020PA1
Veillonella sp., Oral Taxon 780, Strain F0422
Propionibacterium acnes, Strain HL038PA1
Shigella sp., Strain D9
Klebsiella oxytoca, Strain MIT 10-5249
Oscillibacter sp., Strain KLE 1745
Streptococcus sp., Strain SR1
Propionibacterium acnes, Strain HL036PA1
Staphylococcus hominis B3
Escherichia coli, Strain MS 85-1
Streptococcus gallolyticus subsp. gallolyticus, Strain TX20005
Escherichia coli, Strain MS 145-7
Staphylococcus warneri D11
Fusobacterium nucleatum, Strain CTI-05
Lactobacillus jensenii, Strain 269-3
Escherichia coli, Strain MS 119-7
Enterococcus faecalis, Strain R712
Bacteroides sp., Strain 4_1_36
Clostridium orbiscindens, Strain CC43_001K
Staphylococcus epidermidis, Strain NIHLM031
Staphylococcus epidermidis, Strain NIHLM040
Escherichia coli, Strain MS 16-3
Klebsiella oxytoca, Strain MIT 10-5245
Peptoniphilus sp., Oral Taxon 836, Strain F0141
Staphylococcus pasteuri G7
Fusobacterium nucleatum, Strain CTI-05
Corynebacterium sp., Strain HFH0082
Eggerthella sp., Strain MVA1
Prevotella denticola, Strain DNF00960
Fusobacterium sp., Strain CM21
Enterococcus faecium, Strain TX1330
Lactobacillus jensenii, Strain 208-1
Enterococcus faecium, Strain ERV102
Streptococcus sp., Strain BS29a
Streptococcus downei, Oral Taxon 594, Strain F0415
Staphylococcus warneri B9
Staphylococcus warneri E4
Staphylococcus epidermidis, Strain NIH04008
Lactobacillus jensenii, Strain 269-3
Bacteroides sp., Strain 1_1_30
Klebsiella oxytoca, Strain MIT 10-5243
Bacteroides stercoris, Strain CC31F
Erysipelotrichaceae sp., Strain 6_1_45
Fusobacterium sp., Oral Taxon 370, Strain F0437
Prevotella denticola, Strain DNF00960
Bacillus sp., Strain DNF00233
Streptococcus sp., Strain AS20
Fusobacterium sp., Strain CM21
Staphylococcus epidermidis H4
Klebsiella oxytoca, Strain MIT 09-7231
Klebsiella pneumoniae subsp. pneumoniae, Strain WGLW1
Proteus mirabilis, Strain WGLW6
Bacteroides sp., Strain 9_1_42FAA
Staphylococcus epidermidis, Strain NIHLM001
Staphylococcus warneri, Strain SK66
Proteus mirabilis, Strain WGLW4
Arthrobacter albus, Strain DNF00011
Escherichia coli, Strain MS 85-1
Streptococcus sp., Strain ACS2
Staphylococcus warneri, Strain SK66
Escherichia coli, Strain MS 85-1
Streptococcus salivarius, Strain SK126
Klebsiella sp., Strain MS 92-3
Lactobacillus crispatus, Strain JV-V01
Lachnospiraceae bacterium, Strain AAB19
Klebsiella pneumoniae subsp. pneumoniae, Strain WGLW1
Staphylococcus warneri, Strain SK66
Escherichia coli, Strain MS 196-1
Streptococcus anginosus, Strain F0211
Streptococcus salivarius, Strain SK126
Fusobacterium nucleatum subsp. animalis, Oral Taxon 420, Strain F0419
Escherichia coli, Strain MS 200-1
Weissella cibaria, Strain F16_1
Klebsiella pneumoniae subsp. pneumoniae, Strain WGLW3
Bacillus sp., Strain DNF00233
Citrobacter sp., Strain 30_2
Staphylococcus warneri D11
Streptococcus downei, Oral Taxon 594, Strain F0415
Enterococcus faecium, Strain E417
Streptococcus sp., Strain AS20
Streptococcus sobrinus, Strain W1703
Fusobacterium sp., Oral Taxon 370, Strain F0437
Pseudomonas sp., Strain HPB0071
Streptococcus sp., Strain C150
Staphylococcus capitis A7
Propionibacterium acnes, Strain HL005PA1
Escherichia coli, Strain MS 115-1
Propionibacterium acnes, Strain HL060PA1
Staphylococcus capitis D5
Propionibacterium acnes, Strain HL013PA1
Propionibacterium acnes, Strain HL027PA1
Plesiomonas sp., Strain HPP0020
Streptococcus sp., Strain SR1
Bacteroides salyersiae, Strain CL02T12C01
Citrobacter freundii, Strain 4_7_47CFAA
Enterococcus faecalis, Strain TX2137
Bacillus sp., Strain DNF00233
Weissella cibaria, Strain F16_1
Fusobacterium nucleatum, Strain CTI-03
Prevotella bivia, Strain DNF00650
Escherichia coli, Strain MS 110-3
Propionibacterium acnes, Strain HL030PA1
Propionibacterium acnes, Strain HL044PA1
Veillonella sp., Oral Taxon 780, Strain F0422
Bacteroides sp., Strain AAB9
Propionibacterium acnes, Strain HL043PA2
Escherichia coli, Strain MS 115-1
Bacteroides sp., Strain AAB9
Propionibacterium acnes, Strain HL036PA1
Streptococcus mitis, Strain F0392
Streptococcus salivarius, Strain SK126
Staphylococcus epidermidis, Strain E13A
Propionibacterium acnes, Strain HL044PA1
Staphylococcus pasteuri E5
Erysipelotrichaceae sp., Strain 6_1_45
Enterococcus faecalis, Strain S613
Staphylococcus warneri, Strain SK66
Klebsiella oxytoca, Strain MIT 10-5250
Staphylococcus capitis A7
Escherichia coli, Strain MS 145-7
Streptococcus sp., Strain AS20
Staphylococcus pasteuri G3
Streptococcus sp., Strain SR1
Eubacterium sp., Strain 3_1_31
Staphylococcus saprophyticus F6
Klebsiella oxytoca, Strain MIT 09-7231
Staphylococcus pasteuri E5
Propionibacterium acnes, Strain HL036PA3
Lactobacillus jensenii, Strain EX849587VC03
Escherichia coli, Strain MS 69-1
Staphylococcus aureus, Strain TCH70
Enterococcus faecium, Strain TX0133a04
Oscillibacter sp., Strain KLE-1728
Staphylococcus capitis B12
Escherichia coli, Strain MS 57-2
Rothia mucilaginosa, Strain CC87LB
Staphylococcus capitis A7
Lactobacillus crispatus, Strain JV-V01
Streptococcus sp., Strain AS20
Staphylococcus epidermidis G4
Staphylococcus capitis B8
Enterococcus faecium, Strain TX1330
Streptococcus salivarius, Strain SK126
Plesiomonas sp., Strain HPP0020
Allobaculum sp., Strain NWP324
Eggerthella sp., Strain MVA1
Clostridium sp., Strain MSTE9
Escherichia coli, Strain MS 57-2
Propionibacterium acnes, Strain HL060PA1
Deinococcus grandis, Strain SK125
Bifidobacterium sp., Strain MSTE12
Blautia sp., Strain AAB30
Bacteroides stercoris, Strain CC31F
Proteus mirabilis, Strain WGLW6
Propionibacterium acnes, Strain HL001PA1
Escherichia coli, Strain MS 57-2
Lachnospiraceae bacterium, Strain AAB19
Escherichia sp., Strain 3_2_53FAA
Clostridiales bacterium, Strain 4_1_37FAA
Selenomonas noxia, Strain F0398
Corynebacterium amycolatum, Strain SK46
Ruminococcus gnavus, Strain NWP325
Citrobacter sp., Strain 30_2
Propionibacterium acnes, Strain HL050PA3
Micrococcus luteus, Strain SK58
Corynebacterium amycolatum, Strain SK46
Arthrobacter albus, Strain DNF00011
Blautia sp., Strain AAB30
Streptococcus salivarius, Strain SK126
Proteus mirabilis, Strain WGLW4
Prevotella histicola, Strain F0411
Propionibacterium acnes, Strain HL037PA1
Eggerthella sp., Strain MVA1
Corynebacterium sp., Strain HFH0082
Propionibacterium sp., Strain 5_U_42AFAA
Megasphaera micronuciformis, Strain DNF00954
Veillonella sp., Oral Taxon 780, Strain F0422
Bifidobacterium longum subsp. longum, Strain 44B
Streptococcus gallolyticus subsp. gallolyticus, Strain TX20005
Acidaminococcus sp., Strain HPA0509
Klebsiella sp., Strain MS 92-3
Staphylococcus warneri D9
Staphylococcus warneri B9
Fusobacterium sp., Strain CM22
Escherichia coli, Strain MS 200-1
Fusobacterium nucleatum, Strain CTI-06
Escherichia coli, Strain 83972
Proteus mirabilis, Strain WGLW6
Klebsiella oxytoca, Strain MIT 10-5249
Prevotella timonensis, Strain CRIS 5C-B1
Bacteroides sp., Strain D2
Propionibacterium acnes, Strain HL005PA2
Lactobacillus gasseri, Strain JV-V03
Citrobacter sp., Strain 30_2
Streptococcus sobrinus, Strain W1703
Lactobacillus jensenii, Strain EX849587VC03
Propionibacterium acnes, Strain HL036PA3
Citrobacter sp., Strain 30_2
Bacteroides sp., Strain 1_1_30
Blautia sp., Strain AAB30
Peptoniphilus sp., Strain CMW7756A
Lactobacillus gasseri, Strain EX33690VC16
Sporosarcina sp., Strain 2681
Propionibacterium acnes, Strain HL005PA2
Erysipelotrichaceae sp., Strain 6_1_45
Bacillus sp., Strain DNF00233
Staphylococcus epidermidis F6
Propionibacterium acnes, Strain HL037PA2
Staphylococcus capitis B8
Corynebacterium sp., Strain CMW7794
Staphylococcus epidermidis, Strain NIHLM001
Collinsella sp., Strain 4_8_47FAA
Coprococcus sp., Strain AAb34
Propionibacterium acnes, Strain HL005PA4
Escherichia coli, Strain MS 145-7
Escherichia coli, Strain 83972
Staphylococcus warneri, Strain SK66
Prevotella bivia, Strain DNF00650
Streptococcus parasanguinis, Strain F0449
Proteus mirabilis, Strain WGLW6
Staphylococcus capitis C4
Escherichia sp., Strain 3_2_53FAA
Collinsella sp., Strain 4_8_47FAA
Staphylococcus epidermidis D4
Erysipelotrichaceae sp., Strain 6_1_45
Coprococcus sp., Strain AAb34
Escherichia sp., Strain 3_2_53FAA
Staphylococcus saprophyticus D10
Escherichia coli, Strain MS 85-1
Proteus mirabilis, Strain WGLW6
Klebsiella oxytoca, Strain MIT 10-5242
Lactobacillus gasseri, Strain SV-16A-US
Lactobacillus gasseri, Strain 224-1
Escherichia coli, Strain MS 21-1
Ruminococcus gnavus, Strain NWP326
Bifidobacterium breve, Strain JCP7499
Escherichia coli, Strain MS 145-7
Staphylococcus warneri E4
Klebsiella pneumoniae subsp. pneumoniae, Strain WGLW5
Enterococcus faecalis, Strain TX2137
Dorea formicigenerans, Strain AAB36
Peptoniphilus lacrimalis, Strain UPII 315-B
Citrobacter freundii, Strain 4_7_47CFAA
Bacteroides sp., Strain D2
Klebsiella sp., Strain 4_1_44FAA
Bacteroides sp., Strain 9_1_42FAA
Staphylococcus haemolyticus B5
Fusobacterium sp., Strain CM22
Staphylococcus haemolyticus G2
Prevotella bivia, Strain DNF00650
Plesiomonas sp., Strain HPP0020
Staphylococcus hominis B3
Klebsiella sp., Strain MS 92-3
Fusobacterium periodonticum, Strain 2_1_31
Streptococcus sp., Strain C150
Eubacterium infirmum, Strain F0142
Staphylococcus warneri D11
Klebsiella oxytoca, Strain MIT 10-5246
Clostridium difficile, Strain 050-P50-2011
Allobaculum sp., Strain NWP324
Proteus mirabilis, Strain WGLW6
Peptoniphilus lacrimalis, Strain UPII 315-B
Escherichia coli, Strain MS 69-1
Bacteroides sp., Strain D2
Staphylococcus warneri F1
Streptococcus salivarius, Strain SK126
Propionibacterium acnes, Strain HL002PA1
Enterococcus faecium, Strain ERV165
Enterococcus faecium, Strain ERV102
Escherichia coli, Strain MS 69-1
Enterococcus faecium, Strain TX1330
Streptococcus sp., Strain OBRC6
Staphylococcus capitis A7
Prevotella timonensis, Strain CRIS 5C-B1
Streptococcus salivarius, Strain SK126
Streptococcus downei, Oral Taxon 594, Strain F0415
Propionibacterium acnes, Strain HL036PA2
Proteus mirabilis, Strain WGLW6
Bacteroidales bacterium, Strain KA00344
Citrobacter freundii, Strain 4_7_47CFAA
Escherichia coli, Strain MS 16-3
Prevotella bivia, Strain DNF00650
Sporosarcina sp., Strain 2681
Staphylococcus capitis A7
Citrobacter freundii, Strain 4_7_47CFAA
Staphylococcus aureus, Strain TCH70
Enterococcus faecium, Strain ERV102
Lactobacillus parafarraginis, Strain F0439
Staphylococcus haemolyticus G9
Lactobacillus parafarraginis, Strain F0439
Klebsiella pneumoniae subsp. pneumoniae, Strain WGLW2
Lactobacillus jensenii, Strain EX849587VC06
Streptococcus intermedius, Strain F0413
Staphylococcus epidermidis, Strain NIHLM067
Arthrobacter albus, Strain DNF00011
Clostridiales sp., Oral Taxon 876, Strain F0540
Actinomyces neuii, Strain MJR8396A
Lactobacillus jensenii, Strain 269-3
Proteus mirabilis, Strain WGLW6
Escherichia coli, Strain MS 200-1
Staphylococcus capitis C12
Staphylococcus warneri F1
Staphylococcus epidermidis, Strain NIH04008
Escherichia coli, Strain MS 57-2
Staphylococcus aureus, Strain MN8
Bacteroides sp., Strain D2
Propionibacterium acnes, Strain HL036PA1
Eubacterium sp., Strain 3_1_31
Fusobacterium sp., Oral Taxon 370, Strain F0437
Propionibacterium acnes, Strain HL027PA1
Staphylococcus warneri D11
Corynebacterium sp., Strain HFH0082
Arthrobacter albus, Strain DNF00011
Staphylococcus haemolyticus B6
Escherichia coli, Strain MS 145-7
Propionibacterium acnes, Strain HL030PA1
Streptococcus cristatus, Strain F0329
Klebsiella oxytoca, Strain MIT 10-5245
Staphylococcus capitis A7
Staphylococcus epidermidis, Strain NIHLM008
Escherichia coli, Strain MS 16-3
Staphylococcus intermedius F7
Fusobacterium nucleatum, Strain CTI-07
Erysipelotrichaceae sp., Strain 6_1_45
Lactobacillus jensenii, Strain 269-3
Staphylococcus aureus, Strain CM05
Klebsiella pneumoniae subsp. pneumoniae, Strain WGLW2
Escherichia coli, Strain MS 145-7
Rhodococcus erythropolis, Strain SK121
Proteus mirabilis, Strain WGLW6
Streptococcus mitis, Strain F0392
Prevotella sp., Oral Taxon 472, Strain F0295
Staphylococcus epidermidis, Strain NIHLM001
Propionibacterium acnes, Strain HL036PA2
Streptococcus sp., Strain OBRC6
Propionibacterium acnes, Strain HL005PA1
Deinococcus grandis, Strain SK125
Fusobacterium sp., Strain CM21
Eubacterium sp., Strain AS15
Staphylococcus epidermidis D4
Staphylococcus epidermidis, Strain NIHLM031
Staphylococcus warneri B9
Staphylococcus pasteuri G3
Staphylococcus epidermidis, Strain NIH04008
Streptococcus sp., Strain OBRC6
Staphylococcus capitis A7
Escherichia coli, Strain MS 200-1
Bacteroides stercoris, Strain CC31F
Prevotella bivia, Strain DNF00650
Fusobacterium nucleatum, Strain CTI-07
Enterococcus faecium, Strain ERV165
Plesiomonas sp., Strain HPP0020
Streptococcus cristatus, Strain F0329
Klebsiella sp., Strain 4_1_44FAA
Streptococcus mitis, Strain F0392
Clostridium orbiscindens, Strain 1_3_50AFAA
Staphylococcus capitis B8
Klebsiella pneumoniae subsp. pneumoniae, Strain WGLW3
Streptococcus intermedius, Strain F0413
Staphylococcus saprophyticus E8
Staphylococcus warneri D11
Collinsella sp., Strain 4_8_47FAA
Collinsella aerofaciens, Strain AAB3
Staphylococcus saprophyticus D6
Escherichia coli, Strain MS 85-1
Citrobacter freundii, Strain 4_7_47CFAA
Fusobacterium sp., Strain CM21
Lachnospiraceae bacterium, Strain AAB26
Lactobacillus gasseri, Strain EX33690VC16
Escherichia coli, Strain MS 21-1
Escherichia coli, Strain MS 196-1
Escherichia coli, Strain MS 69-1
Dorea sp., Strain AAB35
Catabacter hongkongensis, Strain AB8_9
Proteus mirabilis, Strain WGLW4
Enterococcus faecium, Strain ERV102
Propionibacterium acnes, Strain HL043PA2
Klebsiella pneumoniae subsp. pneumoniae, Strain WGLW3
Klebsiella sp., Strain OBRC7
Fusobacterium nucleatum, Strain CTI-07
Lactobacillus gasseri, Strain EX33690VC16
Fusobacterium nucleatum, Strain CTI-03
Klebsiella pneumoniae subsp. pneumoniae, Strain WGLW3
Streptococcus sp., Strain CM7
Capnocytophaga sp., Oral Taxon 336, Strain F0502
Klebsiella pneumoniae subsp. pneumoniae, Strain WGLW1
Escherichia coli, Strain MS 145-7
Staphylococcus warneri F1
Corynebacterium sp., Strain HFH0082
Propionibacterium acnes, Strain HL005PA4
Blautia sp., Strain AAB30
Proteus mirabilis, Strain WGLW4
Staphylococcus capitis A7
Streptococcus sp., Strain SR4
Staphylococcus epidermidis F12
Micrococcus luteus, Strain SK58
Fusobacterium sp., Strain OBRC1
Corynebacterium amycolatum, Strain SK46
Corynebacterium sp., Strain CMW7794
Micrococcus luteus, Strain SK58
Staphylococcus hominis, Strain C80
Staphylococcus aureus, Strain MN8
Streptococcus sp., Strain OBRC6
Klebsiella oxytoca, Strain MIT 10-5250
Staphylococcus aureus, Strain CM05
Erysipelotrichaceae sp., Strain 6_1_45
Klebsiella oxytoca, Strain MIT 10-5248
Klebsiella sp., Strain OBRC7
Bacteroides stercoris, Strain CC31F
Staphylococcus warneri D9
Bacteroides sp., Strain D2
Staphylococcus epidermidis H12
Lachnospiraceae sp., Strain DNF00160
Enterococcus faecalis, Strain HH22
Peptostreptococcus sp., Strain CC14N
Staphylococcus warneri E4
Staphylococcus epidermidis C6
Escherichia coli, Strain MS 57-2
Propionibacterium acnes, Strain HL005PA4
Streptococcus parasanguinis, Strain F0449
Escherichia coli, Strain MS 85-1
Propionibacterium acnes, Strain HL020PA1
Arthrobacter albus, Strain DNF00011
Staphylococcus pasteuri C9
Streptococcus sp., Strain CM6
Propionibacterium acnes, Strain HL060PA1
Prevotella bivia, Strain DNF00650
Plesiomonas sp., Strain HPP0020
Escherichia coli, Strain MS 145-7
Escherichia coli, Strain MS 196-1
Achromobacter xylosoxidans, Strain C54
Fusobacterium sp., Oral Taxon 370, Strain F0437
Eggerthella sp., Strain MVA1
Klebsiella oxytoca, Strain MIT 10-5246
Bacteroidales bacterium, Strain KA00344
Citrobacter freundii, Strain 4_7_47CFAA
Escherichia coli, Strain MS 196-1
Escherichia coli, Strain MS 200-1
Escherichia coli, Strain 83972
Klebsiella oxytoca, Strain MIT 10-5250
Streptococcus sp., Strain SR1
Escherichia coli, Strain MS 145-7
Propionibacterium acnes, Strain HL036PA3
Streptococcus gallolyticus subsp. gallolyticus, Strain TX20005
Klebsiella sp., Strain 4_1_44FAA
Enterococcus faecium, Strain TX1330
Propionibacterium acnes, Strain SK137
Lactobacillus gasseri, Strain EX33690VC16
Staphylococcus epidermidis, Strain NIHLM001
Staphylococcus capitis C4
Staphylococcus hominis A9
Staphylococcus haemolytics, Strain DNF00585
Escherichia coli, Strain MS 200-1
Propionibacterium acnes, Strain HL050PA1
Fusobacterium nucleatum, Strain CTI-02
Staphylococcus saprophyticus D6
Clostridium bolteae, Strain CC43_001B
Staphylococcus warneri B9
Blautia sp., Strain AAB30
Proteus mirabilis, Strain WGLW6
Escherichia coli, Strain MS 16-3
Streptococcus sp., Strain CM7
Streptococcus gallolyticus subsp. gallolyticus, Strain TX20005
Escherichia coli, Strain MS 145-7
Staphylococcus epidermidis, Strain E13A
Escherichia coli, Strain MS 115-1
Staphylococcus aureus, Strain TCH70
Proteus mirabilis, Strain WGLW6
Corynebacterium sp., Strain CMW7794
Proteus mirabilis, Strain WGLW4
Bacteroides stercoris, Strain CC31F
Staphylococcus lugdunensis, Strain M23590
Escherichia coli, Strain MS 110-3
Lactobacillus jensenii, Strain EX849587VC06
Bacteroides dorei, Strain 5_1_36/D4
Lachnospiraceae sp., Strain DNF00160
Staphylococcus haemolyticus B5
Dorea formicigenerans, Strain AAB36
Streptococcus sp., Strain BS21
Klebsiella sp., Strain 1_1_55
Staphylococcus epidermidis, Strain NIHLM001
Propionibacterium acnes, Strain HL030PA2
Fusobacterium nucleatum, Strain CTI-05
Citrobacter freundii, Strain 4_7_47CFAA
Klebsiella sp., Strain 1_1_55
Propionibacterium acnes, Strain HL002PA1
Staphylococcus capitis E12
Streptococcus sp., Strain ACS2
Staphylococcus warneri E4
Staphylococcus epidermidis F6
Staphylococcus saprophyticus E8
Staphylococcus aureus, Strain CM05
Streptococcus mitis, Strain F0392
Clostridium sp., Strain MSTE9
Staphylococcus hominis, Strain SK119
Enterococcus faecalis, Strain TUSoD Ef11
Streptococcus sp., Strain OBRC6
Proteus mirabilis, Strain WGLW6
Escherichia coli, Strain MS 85-1
Peptoniphilus sp., Oral Taxon 386, Strain F0131
Erysipelotrichaceae sp., Strain 6_1_45
Streptococcus cristatus, Strain F0329
Staphylococcus saprophyticus E8
Coprococcus sp., Strain AAb34
Propionibacterium acidifaciens, Oral Taxon 191, Strain F0233
Propionibacterium acnes, Strain HL025PA1
Escherichia coli, Strain MS 69-1
Veillonella sp., Oral Taxon 780, Strain F0422
Streptococcus cristatus, Strain F0329
Staphylococcus warneri E6
Fusobacterium sp., Strain CM22
Lactobacillus parafarraginis, Strain F0439
Lactobacillus jensenii, Strain EX849587VC06
Staphylococcus warneri B9
Escherichia coli, Strain MS 69-1
Fusobacterium nucleatum, Strain CTI-05
Fusobacterium periodonticum, Strain 2_1_31
Escherichia coli, Strain MS 145-7
Klebsiella pneumoniae subsp. pneumoniae, Strain WGLW3
Staphylococcus warneri D9
Proteus mirabilis, Strain WGLW4
Bacteroides fragilis, Strain 3_1_12
Staphylococcus epidermidis D4
Streptococcus sp., Strain OBRC6
Escherichia coli, Strain MS 110-3
Lactobacillus crispatus, Strain JV-V01
Clostridium innocuum, Strain 6_1_30
Propionibacterium acnes, Strain HL038PA1
Shigella sp., Strain D9
Fusobacterium nucleatum, Strain CTI-07
Staphylococcus warneri E4
Enterococcus faecium, Strain E417
Staphylococcus capitis D5
Klebsiella oxytoca, Strain MIT 10-5246
Streptococcus gallolyticus subsp. gallolyticus, Strain TX20005
Fusobacterium nucleatum, Strain CTI-05
Bacillus sp., Strain DNF00233
Staphylococcus pasteuri F12
Lactobacillus gasseri, Strain EX33690VC16
Proteus mirabilis, Strain WGLW4
Ruminococcus gnavus, Strain AAB28
Klebsiella oxytoca, Strain MIT 10-5248
Peptoniphilus sp., Oral Taxon 386, Strain F0131
Staphylococcus warneri E6
Staphylococcus capitis E7
Lactobacillus reuteri, Strain CF48-3A
Clostridium cadaveris, Strain CC40_001C
Eubacterium sp., Strain AS15
Lactobacillus gasseri, Strain SV-16A-US
Clostridium symbiosum, Strain WAL-14673
Prevotella veroralis, Oral Taxon 572, Strain F0319
Enterococcus faecium, Strain ERV99
Allobaculum sp., Strain NWP324
Corynebacterium amycolatum, Strain SK46
Lactobacillus gasseri, Strain JV-V03
Klebsiella sp., Strain MS 92-3
Finegoldia magna, Strain SY01
Staphylococcus pasteuri E5
Micrococcus luteus, Strain SK58
Fusobacterium nucleatum, Strain CTI-07
Dorea sp., Strain AAB35
Lachnospiraceae bacterium, Strain AAB19
Streptococcus gallolyticus subsp. gallolyticus, Strain TX20005
Fusobacterium sp., Strain CM22
Citrobacter freundii, Strain 4_7_47CFAA
Pseudomonas sp., Strain HPB0071
Propionibacterium acnes, Strain HL038PA1
Lactobacillus gasseri, Strain JV-V03
Ruminococcus sp., Strain AAB27
Streptococcus parasanguinis, Strain F0449
Staphylococcus epidermidis, Strain NIH04008
Propionibacterium acnes, Strain HL025PA2
Propionibacterium acidifaciens, Oral Taxon 191, Strain F0233
Staphylococcus capitis B12
Klebsiella oxytoca, Strain MIT 10-5246
Streptococcus cristatus, Strain F0329
Bacteroides sp., Strain D2
Fusobacterium sp., Oral Taxon 370, Strain F0437
Klebsiella sp., Strain OBRC7
Staphylococcus pasteuri G7
Staphylococcus warneri F1
Bacteroides sp., Strain 4_1_36
Selenomonas noxia, Strain F0398
Staphylococcus warneri, Strain SK66
Lactobacillus gasseri, Strain JV-V03
Staphylococcus epidermidis, Strain NIHLM023
Coprococcus sp., Strain AAb34
Lactobacillus gasseri, Strain JV-V03
Klebsiella oxytoca, Strain MIT 10-5243
Staphylococcus capitis E7
Staphylococcus epidermidis, Strain NIH04008
Propionibacterium acnes, Strain HL005PA2
Megasphaera micronuciformis, Strain DNF00954
Staphylococcus capitis C11
Staphylococcus warneri A2
Lactobacillus gasseri, Strain JV-V03
Capnocytophaga sp., Oral Taxon 336, Strain F0502
Propionibacterium acnes, Strain HL013PA1
Staphylococcus warneri E4
Enterococcus faecium, Strain ERV102
Clostridiales bacterium, Strain 4_1_37FAA
Clostridium bolteae, Strain CC43_001B
Proteus mirabilis, Strain WGLW6
Staphylococcus warneri D11
Staphylococcus saprophyticus E8
Bifidobacterium breve, Strain HPH0326
Propionibacterium acnes, Strain HL043PA1
Staphylococcus saprophyticus E2
Fusobacterium sp., Strain CM22
Staphylococcus caprae, Strain C87
Propionibacterium acnes, Strain HL005PA1
Proteus mirabilis, Strain WGLW4
Allobaculum sp., Strain NWP324
Propionibacterium acnes, Strain HL005PA2
Corynebacterium sp., Strain HFH0082
Escherichia coli, Strain MS 115-1
Fusobacterium sp., Strain CM21
Prevotella denticola, Oral Taxon 291, Strain F0289
Escherichia coli, Strain MS 119-7
Escherichia coli, Strain MS 145-7
Bacteroides sp., Strain D2
Erysipelotrichaceae sp., Strain 6_1_45
Escherichia coli, Strain MS 119-7
Klebsiella oxytoca, Strain MIT 10-5249
Dorea formicigenerans, Strain AAB36
Escherichia coli, Strain MS 145-7
Staphylococcus pasteuri F12
Streptococcus intermedius, Strain F0413
Veillonella sp., Oral Taxon 780, Strain F0422
Clostridium sp., Strain MSTE9
Sporosarcina sp., Strain 2681
Lactobacillus gasseri, Strain JV-V03
Staphylococcus saprophyticus D6
Escherichia coli, Strain MS 16-3
Escherichia coli, Strain MS 115-1
Klebsiella oxytoca, Strain MIT 10-5249
Klebsiella oxytoca, Strain MIT 10-5242
Staphylococcus capitis C11
Bacteroides sp., Strain AAB8
Streptococcus salivarius, Strain SK126
Streptococcus mitis, Strain F0392
Parabacteroides merdae, Strain CL09T00C40
Klebsiella oxytoca, Strain MIT 10-5242
Escherichia coli, Strain MS 145-7
Staphylococcus aureus, Strain MN8
Staphylococcus epidermidis, Strain NIHLM003
Lactobacillus crispatus, Strain GED7749C
Escherichia coli, Strain MS 57-2
Staphylococcus capitis C11
Prevotella histicola, Strain F0411
Plesiomonas sp., Strain HPP0020
Enterococcus faecium, Strain ERV102
Staphylococcus warneri D11
Klebsiella oxytoca, Strain MIT 10-5246
Oscillibacter sp., Strain KLE 1745
Dorea sp., Strain AAB35
Peptostreptococcus sp., Strain CC14N
Staphylococcus aureus, Strain CM05
Fusobacterium periodonticum, Strain 2_1_31
Staphylococcus hominis, Strain SK119
Megasphaera micronuciformis, Strain DNF00954
Erysipelotrichaceae sp., Strain 6_1_45
Staphylococcus capitis, Strain SK14
Escherichia coli, Strain MS 119-7
Streptococcus sp., Strain OBRC6
Erysipelotrichaceae sp., Strain 6_1_45
Propionibacterium acnes, Strain HL013PA1
Streptococcus sp., Strain C150
Clostridium sp., Strain HGF2
Escherichia coli, Strain 83972
Staphylococcus epidermidis, Strain NIHLM040
Streptococcus cristatus, Strain F0329
Klebsiella pneumoniae subsp. pneumoniae, Strain WGLW1
Corynebacterium sp., Strain HFH0082
Citrobacter freundii, Strain 4_7_47CFAA
Fusobacterium nucleatum subsp. animalis, Oral Taxon 420, Strain F0419
Proteus mirabilis, Strain WGLW6
Klebsiella oxytoca, Strain MIT 10-5249
Propionibacterium acnes, Strain HL056PA1
Clostridium orbiscindens, Strain CC43_001K
Streptococcus sp., Strain ACC21
Propionibacterium acnes, Strain HL005PA4
Prevotella oralis, Strain HGA0225
Staphylococcus epidermidis, Strain NIHLM067
Streptococcus cristatus, Strain F0329
Staphylococcus epidermidis, Strain NIHLM020
Eubacterium sp., Strain 3_1_31
Klebsiella sp., Strain 1_1_55
Staphylococcus capitis B8
Plesiomonas sp., Strain HPP0020
Streptococcus downei, Oral Taxon 594, Strain F0415
Staphylococcus capitis A7
Veillonella sp., Oral Taxon 780, Strain F0422
Staphylococcus hominis B3
Lactobacillus jensenii, Strain EX849587VC06
Staphylococcus aureus, Strain CM05
Escherichia coli, Strain MS 145-7
Staphylococcus capitis D5
Klebsiella sp., Strain 4_1_44FAA
Staphylococcus capitis E7
Bacteroides stercoris, Strain CC31F
Escherichia coli, Strain 83972
Fusobacterium periodonticum, Strain 2_1_31
Proteus mirabilis, Strain WGLW6
Streptococcus sp., Strain AS20
Bacillus sp., Strain DNF00233
Streptococcus sp., Strain C150
Propionibacterium acnes, Strain HL045PA1
Escherichia coli, Strain MS 115-1
Klebsiella pneumoniae subsp. pneumoniae, Strain WGLW2
Staphylococcus capitis B12
Streptococcus gallolyticus subsp. gallolyticus, Strain TX20005
Clostridium cadaveris, Strain CC44_001G
Escherichia coli, Strain MS 57-2
Pseudomonas sp., Strain HPB0071
Klebsiella sp., Strain MS 92-3
Oscillibacter sp., Strain KLE 1745
Fusobacterium periodonticum, Strain 2_1_31
Lactobacillus jensenii, Strain EX849587VC06
Staphylococcus pasteuri C9
Propionibacterium acnes, Strain HL046PA2
Klebsiella oxytoca, Strain MIT 10-5249
Staphylococcus warneri, Strain SK66
Escherichia coli, Strain MS 16-3
Clostridium symbiosum, Strain WAL-14673
Escherichia coli, Strain MS 115-1
Lactobacillus gasseri, Strain JV-V03
Staphylococcus capitis B1
Prevotella melaninogenica, Strain D18
Staphylococcus epidermidis F6
Bacteroides stercoris, Strain CC31F
Bacteroides sp., Strain D2
Propionibacterium acnes, Strain HL002PA2
Klebsiella sp., Strain 4_1_44FAA
Enterococcus faecalis, Strain HH22
Propionibacterium acnes, Strain HL013PA1
Staphylococcus warneri B9
Weissella cibaria, Strain F16_1
Enterococcus faecalis, Strain TX2137
Lactobacillus jensenii, Strain 269-3
Peptoniphilus sp., Oral Taxon 836, Strain F0141
Propionibacterium acnes, Strain HL002PA3
Staphylococcus warneri C5
Staphylococcus hominis B3
Dermabacter sp., Strain HFH0086
Prevotella bivia, Strain DNF00650
Corynebacterium amycolatum, Strain SK46
Coprococcus sp., Strain AAb34
Streptococcus gallolyticus subsp. gallolyticus, Strain TX20005
Streptococcus vestibularis, Strain F0396
Bacillus sp., Strain DNF00233
Erysipelotrichaceae sp., Strain 6_1_45
Bacteroides stercoris, Strain CC31F
Lactobacillus crispatus, Strain JV-V01
Klebsiella oxytoca, Strain MIT 10-5243
Lactobacillus jensenii, Strain EX849587VC06
Enterococcus faecium, Strain E417
Staphylococcus hominis, Strain C80
Bacillus sp., Strain DNF00233
Enterococcus faecalis, Strain S613
Streptococcus sp., Strain BS21
Clostridium cadaveris, Strain CC44_001G
Propionibacterium acnes, Strain HL059PA1
Bacteroidales bacterium, Strain KA00344
Streptococcus anginosus, Strain F0211
Clostridium difficile, Strain 002-P50-2011
Enterococcus faecium, Strain TX0133a04
Streptococcus sp., Strain C150
Staphylococcus capitis C4
Prevotella bivia, Strain DNF00650
Enterococcus faecalis, Strain TX2137
Fusobacterium sp., Strain CM21
Propionibacterium acnes, Strain HL005PA1
Klebsiella pneumoniae subsp. pneumoniae, Strain WGLW3
Staphylococcus warneri D9
Escherichia coli, Strain MS 16-3
Propionibacterium acnes, Strain HL056PA1
Proteus mirabilis, Strain WGLW6
Fusobacterium nucleatum, Strain CTI-05
Capnocytophaga sputigena, Strain CC21_001D
Escherichia coli, Strain MS 145-7
Clostridium difficile, Strain 050-P50-2011
Propionibacterium acnes, Strain HL020PA1
Klebsiella oxytoca, Strain MIT 09-7231
Staphylococcus warneri E4
Streptococcus sp., Strain OBRC6
Megasphaera sp., Strain DNF00872
Staphylococcus warneri D4
Streptococcus sp., Strain C150
Eggerthella sp., Strain MVA1
Klebsiella sp., Strain MS 92-3
Lactobacillus gasseri, Strain EX33690VC16
Escherichia sp., Strain 3_2_53FAA
Staphylococcus epidermidis C3
Fusobacterium nucleatum, Strain CTI-06
Streptococcus mitis, Strain F0392
Staphylococcus warneri E6
Staphylococcus capitis C12
Klebsiella pneumoniae subsp. pneumoniae, Strain WGLW5
Escherichia coli, Strain MS 16-3
Staphylococcus simulans F10
Staphylococcus pasteuri F11
Enterococcus faecium, Strain ERV102
Staphylococcus caprae, Strain C87
Streptococcus mitis, Strain F0392
Propionibacterium acnes, Strain HL027PA1
Staphylococcus hominis, Strain C80
Prevotella bivia, Strain DNF00650
Propionibacterium acnes, Strain HL053PA2
Prevotella melaninogenica, Strain D18
Finegoldia magna, Strain GED7760A
Staphylococcus warneri C2
Escherichia coli, Strain MS 85-1
Klebsiella pneumoniae subsp. pneumoniae, Strain WGLW2
Staphylococcus epidermidis, Strain NIHLM067
Arthrobacter albus, Strain DNF00011
Klebsiella oxytoca, Strain MIT 10-5249
Propionibacterium acnes, Strain HL053PA2
Streptococcus sp., Strain ACS2
Enterococcus faecalis, Strain TX2137
Staphylococcus capitis B12
Lactobacillus crispatus, Strain 125-2-CHN
Propionibacterium acnes, Strain HL005PA2
Staphylococcus warneri C2
Streptococcus gallolyticus subsp. gallolyticus, Strain TX20005
Bacteroides stercoris, Strain CC31F
Enterococcus faecium, Strain E417
Lactobacillus jensenii, Strain 208-1
Escherichia sp., Strain 3_2_53FAA
Staphylococcus hominis, Strain C80
Staphylococcus caprae, Strain C87
Bacteroidales bacterium, Strain KA00344
Erysipelotrichaceae sp., Strain 6_1_45
Klebsiella oxytoca, Strain MIT 10-5250
Rothia mucilaginosa, Strain CC87LB
Proteus mirabilis, Strain WGLW6
Clostridiales bacterium, Strain 4_1_37FAA
Selenomonas noxia, Strain F0398
Klebsiella oxytoca, Strain MIT 09-7231
Staphylococcus warneri D11
Proteus mirabilis, Strain WGLW6
Streptococcus cristatus, Strain F0329
Weissella cibaria, Strain F16_1
Staphylococcus saprophyticus D6
Streptococcus sp., Strain CM7
Fusobacterium sp., Strain CM22
Bacteroides stercoris, Strain CC31F
Proteus mirabilis, Strain WGLW6
Fusobacterium periodonticum, Strain 1_A_54/D10
Staphylococcus warneri E4
Propionibacterium acnes, Strain HL043PA1
Enterococcus faecalis, Strain TX2137
Hungatella hathewayi, Strain WAL-18680
Deinococcus grandis, Strain SK125
Staphylococcus warneri E6
Propionibacterium acnes, Strain HL053PA1
Streptococcus sp., Strain AS20
Fusobacterium nucleatum subsp. animalis, Oral Taxon 420, Strain F0419
Citrobacter sp., Strain 30_2
Lactobacillus gasseri, Strain EX33690VC16
Enterococcus faecium, Strain ERV165
Streptococcus mitis, Strain F0392
Staphylococcus pasteuri F11
Megasphaera sp., Strain DNF00912
Staphylococcus warneri D11
Propionibacterium acnes, Strain HL043PA1
Lactobacillus jensenii, Strain EX849587VC03
Escherichia coli, Strain MS 119-7
Prevotella histicola, Strain F0411
Eggerthella sp., Strain MVA1
Escherichia coli, Strain MS 85-1
Peptoniphilus sp., Oral Taxon 836, Strain F0141
Staphylococcus capitis C11
Proteus mirabilis, Strain WGLW6
Streptococcus gallolyticus subsp. gallolyticus, Strain TX20005
Enterococcus faecium, Strain ERV102
Micrococcus luteus, Strain SK58
Eubacterium sp., Strain 3_1_31
Klebsiella oxytoca, Strain MIT 10-5248
Propionibacterium acnes, Strain HL027PA2
Propionibacterium acnes, Strain HL053PA1
Klebsiella sp., Strain MS 92-3
Klebsiella oxytoca, Strain MIT 10-5246
Staphylococcus hominis A4
Escherichia coli, Strain MS 85-1
Lactobacillus parafarraginis, Strain F0439
Weissella cibaria, Strain F16_1
Klebsiella oxytoca, Strain MIT 10-5249
Escherichia coli, Strain MS 119-7
Escherichia coli, Strain MS 69-1
Lactobacillus gasseri, Strain 224-1
Enterococcus faecium, Strain ERV102
Staphylococcus haemolyticus B5
Propionibacterium acnes, Strain HL013PA1
Staphylococcus capitis E7
Streptococcus sp., Strain SR4
Escherichia coli, Strain MS 16-3
Lactobacillus gasseri, Strain 224-1
Bifidobacterium angulatum, Strain F16_22
Staphylococcus aureus, Strain CM05
Blautia sp., Strain KLE 1732
Allobaculum sp., Strain NWP324
Proteus mirabilis, Strain WGLW6
Propionibacterium acnes, Strain HL025PA2
Lachnospiraceae sp., Strain DNF00160
Fusobacterium sp., Oral Taxon 370, Strain F0437
Oscillibacter sp., Strain KLE 1745
Proteus mirabilis, Strain WGLW6
Enterococcus faecium, Strain ERV102
Propionibacterium acnes, Strain HL025PA2
Prevotella bivia, Strain DNF00188
Escherichia coli, Strain MS 119-7
Staphylococcus capitis, Strain SK14
Staphylococcus epidermidis, Strain W23144
Streptococcus gallolyticus subsp. gallolyticus, Strain TX20005
Escherichia coli, Strain MS 119-7
Fusobacterium sp., Strain CM22
Staphylococcus epidermidis, Strain E13A
Enterococcus faecium, Strain TX0133a04
Enterococcus faecalis, Strain TX2137
Erysipelotrichaceae sp., Strain 6_1_45
Propionibacterium acnes, Strain HL078PA1
Staphylococcus epidermidis, Strain NIHLM023
Streptococcus salivarius, Strain SK126
Propionibacterium acnes, Strain HL043PA2
Propionibacterium acnes, Strain HL060PA1
Clostridium difficile, Strain 050-P50-2011
Rothia mucilaginosa, Strain CC87LB
Erysipelotrichaceae sp., Strain 6_1_45
Streptococcus mitis, Strain F0392
Propionibacterium acnes, Strain HL005PA2
Shigella sp., Strain D9
Fusobacterium sp., Strain CM22
Klebsiella oxytoca, Strain MIT 10-5245
Escherichia sp., Strain 3_2_53FAA
Staphylococcus warneri D3
Streptococcus sp., Strain OBRC6
Fusobacterium sp., Strain CM21
Staphylococcus epidermidis G10
Streptococcus sp., Strain BS29a
Fusobacterium sp., Oral Taxon 370, Strain F0437
Staphylococcus epidermidis, Strain NIHLM031
Streptococcus sp., Strain ACS2
Fusobacterium nucleatum, Strain CTI-02
Catabacter hongkongensis, Strain AB8_9
Lachnospiraceae bacterium, Strain AAB23
Staphylococcus capitis B12
Staphylococcus haemolyticus B6
Bifidobacterium longum subsp. longum, Strain 44B
Staphylococcus warneri C5
Erysipelotrichaceae sp., Strain 6_1_45
Bacillus sp., Strain DNF00233
Weissella cibaria, Strain F16_1
Clostridium sp., Strain HGF2
Streptococcus gallolyticus subsp. gallolyticus, Strain TX20005
Streptococcus sobrinus, Strain W1703
Staphylococcus epidermidis, Strain NIHLM003
Streptococcus sp., Strain SR1
Bacteroidales bacterium, Strain KA00344
Clostridiales bacterium, Strain 3_1_39B/D5
Streptococcus mitis, Strain F0392
Staphylococcus warneri E6
Lactobacillus jensenii, Strain 269-3
Escherichia coli, Strain MS 145-7
Staphylococcus pasteuri G3
Staphylococcus epidermidis, Strain NIHLM070
Enterococcus faecium, Strain TX1330
Staphylococcus capitis A7
Staphylococcus warneri D11
Staphylococcus capitis B8
Propionibacterium acnes, Strain HL027PA1
Bacteroides sp., Strain D2
Staphylococcus epidermidis, Strain NIH04008
Streptococcus sp., Strain SR1
Fusobacterium nucleatum, Strain MJR7757B
Escherichia coli, Strain MS 196-1
Corynebacterium sp., Strain CMW7794
Propionibacterium acnes, Strain HL045PA1
Staphylococcus pasteuri E5
Staphylococcus epidermidis, Strain NIHLM001
Proteus mirabilis, Strain WGLW6
Proteus mirabilis, Strain WGLW4
Escherichia coli, Strain MS 119-7
Klebsiella oxytoca, Strain MIT 10-5246
Micrococcus luteus, Strain SK58
Streptococcus sp., Strain C150
Citrobacter sp., Strain 30_2
Escherichia coli, Strain MS 110-3
Fusobacterium nucleatum subsp. animalis, Oral Taxon 420, Strain F0419
Propionibacterium acidifaciens, Oral Taxon 191, Strain F0233
Streptococcus salivarius, Strain SK126
Streptococcus mitis, Strain F0392
Streptococcus cristatus, Strain F0329
Staphylococcus pasteuri G7
Clostridium sp., Strain MSTE9
Staphylococcus cohnii G11
Propionibacterium acnes, Strain HL037PA1
Deinococcus grandis, Strain SK125
Megasphaera micronuciformis, Strain DNF00954
Lactobacillus parafarraginis, Strain F0439
Shuttleworthia sp., Strain MSX8B
Klebsiella oxytoca, Strain MIT 10-5245
Lachnospiraceae sp., Strain DNF00160
Fusobacterium sp., Oral Taxon 370, Strain F0437
Staphylococcus capitis A5
Staphylococcus warneri, Strain SK66
Staphylococcus epidermidis H3
Lactobacillus jensenii, Strain EX849587VC06
Staphylococcus epidermidis, Strain NIH04008
Corynebacterium amycolatum, Strain SK46
Staphylococcus capitis B8
Propionibacterium acnes, Strain HL007PA1
Bacillus sp., Strain DNF00233
Prevotella nigrescens, Strain F0103
Propionibacterium acnes, Strain HL050PA1
Prevotella bivia, Strain GED7760C
Streptococcus sp., Strain AS20
Coprococcus sp., Strain AAb34
Propionibacterium acnes, Strain HL038PA1
Fusobacterium nucleatum, Strain CTI-05
Klebsiella oxytoca, Strain MIT 09-7231
Capnocytophaga sputigena, Strain CC21_001D
Escherichia coli, Strain MS 115-1
Escherichia coli, Strain MS 57-2
Plesiomonas sp., Strain HPP0020
Staphylococcus epidermidis, Strain NIH05001
Propionibacterium acnes, Strain HL059PA1
Fusobacterium sp., Strain CM22
Blautia sp., Strain AAB30
Propionibacterium acnes, Strain HL037PA2
Escherichia sp., Strain 3_2_53FAA
Escherichia coli, Strain MS 85-1
Escherichia coli, Strain MS 110-3
Propionibacterium acnes, Strain HL002PA1
Staphylococcus aureus, Strain TCH70
Finegoldia magna, Strain SY01
Staphylococcus pasteuri G7
Staphylococcus capitis A7
Propionibacterium acnes, Strain HL005PA4
Staphylococcus warneri C5
Escherichia coli, Strain MS 145-7
Citrobacter sp., Strain 30_2
Prevotella melaninogenica, Strain D18
Fusobacterium nucleatum, Strain CTI-07
Staphylococcus pasteuri F12
Enterococcus faecalis, Strain TUSoD Ef11
Streptococcus salivarius, Strain SK126
Staphylococcus gallinarum E9
Shigella sp., Strain D9
Propionibacterium acnes, Strain HL110PA4
Staphylococcus warneri D3
Prevotella histicola, Strain F0411
Fusobacterium sp., Strain CM21
Clostridium sp., Strain MSTE9
Megasphaera sp., Strain DNF00912
The disclosures of each and every patent, patent application, and publication cited herein are hereby incorporated herein by reference in their entirety. While this invention has been disclosed with reference to specific embodiments, it is apparent that other embodiments and variations of this invention may be devised by others skilled in the art without departing from the true spirit and scope of the invention. The appended claims are intended to be construed to include all such embodiments and equivalent variations.
This application claims priority to U.S. Provisional Application No. 63/114,627, filed Nov. 17, 2020 which is hereby incorporated by reference herein in its entirety.
| Filing Document | Filing Date | Country | Kind |
|---|---|---|---|
| PCT/US21/59643 | 11/17/2021 | WO |
| Number | Date | Country | |
|---|---|---|---|
| 63114627 | Nov 2020 | US |
