Claims
- 1. Compounds having the formula ##SPC9##
- wherein
- X and X' are selected from the group consisting of hydrogen, an alkyl group having up to 6 carbon atoms, an alkenyl group having up to 6 carbon atoms, a perfluoroalkyl group having up to 4 carbon atoms, a phenyl or a substituted phenyl radical, amino, an alkylamino group having up to 4 carbon atoms, a dialkylamino group having up to 8 carbon atoms, fluorine, chlorine, bromine, iodine, hydroxyl, an alkoxyl group having up to 4 carbon atoms and a perfluoroalkoxyl group having up to 4 carbon atoms;
- n is an integer selected from the group consisting of 2 and 3;
- R.sub.2 and R.sub.3 are independently selected from the group consisting of hydrogen, alkyl, alkenyl, aralkyl and alkynyl, and m is an integer selected from the group consisting of 1 to 4 inclusive;
- and pharmaceutically acceptable, non-toxic acid addition salts thereof.
- 2. Compounds of claim 1 wherein X' is hydrogen, n is 2 and m is 1.
- 3. A compound of claim 2 having the formula ##SPC10##
- 4. Compounds of claim 1 wherein R.sub.2 and R.sub.3 are hydrogen and m is 1.
- 5. Compounds of claim 4 wherein n is 2.
- 6. A compound of claim 5 having the formula ##SPC11##
- 7. Pharmaceutically acceptable, non-toxic acid addition salts of the compounds of claim 4.
- 8. Pharmaceutically acceptable, non-toxic acid addition salts of the compounds of claim 5.
- 9. Pharmaceutically acceptable, non-toxic acid addition salts of the compounds of claim 6.
- 10. Compounds having the formula ##SPC12##
- wherein
- X and X' are defined as in claim 11;
- n is an integer selected from the group consisting of 2 and 3;
- Alk is alkyl;
- and m is an integer selected from the group consisting of 1 to 4 inclusive
- and pharmaceutically acceptable, non-toxic acid addition salts thereof.
- 11. Compounds of claim 10 wherein n is 2 and m is 1.
- 12. A compound of claim 11 having the formula ##SPC13##
- 13. Compounds having the formula ##SPC14##
- wherein R.sub.2 is lower alkyl.
- 14. N-alkyl and N,N'-dialkyl derivatives of compounds of claim 13.
- 15. Pharmaceutically acceptable, non-toxic acid addition salts of the compounds of claim 14.
- 16. Pharmaceutically acceptable, non-toxic acid addition salts of compounds of claim 13.
- 17. Compounds of claim 13 wherein R.sub.2 is methyl.
- 18. A compound of claim 17 having the formula ##SPC15##
- 19. .alpha.,N-Dimethyl-2-(.alpha.,.alpha.,.beta.,.beta.-tetrafluorophenethyl)-benzylamine.
- 20. .alpha.,.alpha.,.alpha.'-Tetrafluoroethylene-2,2'-bis (benzylamine).
- 21. N,N-Dimethyl-3-(.alpha.,.alpha.,.beta.,.beta.-tetrafluorophenethyl)-o-xylene-.alpha.,.alpha.'-diamine.
- 22. N,N,-Dibenzyl-3-(.alpha.,.alpha.,.beta.,.beta.-tetrafluorophenethyl)-o-xylene-.alpha.,.alpha.'-diamine
- 23. 2-Methyl-3-(.alpha.,.alpha.,.beta.,.beta.-tetrafluorophenethyl)-benzylamine.
- 24. 4-(.alpha.,.alpha.,.beta.,.beta.-Tetrafluorophenethyl)-benzylamine.
- 25. .alpha.-Methyl-4-(.alpha.,.alpha.,.beta.,.beta.-tetrafluorophenethyl)-benzylamine.
- 26. 4-(.alpha.,.alpha.,.beta.,.beta.-Tetrafluorophenethyl)-.alpha.,.alpha.,N-trimethylbenzylamine.
- 27. 4-(.alpha.,.alpha.,.beta.,.beta.-Tetrafluorophenethyl)-.alpha.,.alpha.,N,N-tetramethylbenzylamine.
- 28. 4-(p-Methyl-.alpha.,.alpha.,.beta.,.beta.-tetrafluorophenethyl)-.alpha.,.alpha.,N-trimethylbenzylamine.
Parent Case Info
This application is a division of copending U.S. Application Ser. No. 102,130 filed Dec. 28, 1970, now U.S. Pat. No. 3,812,177 which in turn is a continuation-in-part of U.S. Application Ser. No. 799,945 filed Feb. 2, 1969 and now abandoned, which in turn is a continuation-in-part of application Ser. No. 712,616 filed Mar. 13, 1968 and now abandoned.
US Referenced Citations (3)
Number |
Name |
Date |
Kind |
2441576 |
Jones et al. |
May 1948 |
|
2459338 |
Rawlins et al. |
Jan 1949 |
|
3226448 |
Gordon et al. |
Dec 1965 |
|
Foreign Referenced Citations (1)
Number |
Date |
Country |
624,279 |
Feb 1963 |
BE |
Non-Patent Literature Citations (2)
Entry |
Yagupol'skii et al., "Tetrafluorobibenzyl Derivatives", in J. Gen. Chem. USSR 35: 1616-1623, 9/1965. |
Tomita et al., "Synthesis of Ammonium Comp'ds", in J. Pharm. Society vol. 73, pp. 760-765. |
Divisions (1)
|
Number |
Date |
Country |
Parent |
102130 |
Dec 1970 |
|
Continuation in Parts (2)
|
Number |
Date |
Country |
Parent |
799945 |
Feb 1969 |
|
Parent |
712616 |
Mar 1968 |
|