Claims
- 1. A method of killing cells, comprising contacting said cells with an immunotoxin consisting of at least one antibody and at least one cytotoxin linked by a thioether linkage by reaction with a linker comprising maleimido-6-aminocaproyl-spacer-glutaryl ester of 1-hydroxy-2-nitrobenzene.
- 2. A method as described in claim 1, wherein said antibody is selected from the group consisting of monoclonal, polyclonal or recombinant antibody, or fragments thereof.
- 3. A method as described in claim 2, wherein said cytotoxin is selected from the group consisting of ricin, diphtheria toxin, and abran, or fragments derived therefrom.
- 4. A method as described in claim 3, wherein said cytotoxin is ricin A chain.
- 5. A method for killing cells as described in claim 1, wherein said cells are tumor cells.
Parent Case Info
This application is a division of application Ser. No. 217,938, now abandoned filed 7-12-88.
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EPX |
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Non-Patent Literature Citations (3)
Entry |
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Divisions (1)
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Number |
Date |
Country |
Parent |
217938 |
Jul 1988 |
|