Claims
- 1. Collagen for use as a carrier of bone morphogenic protein for osteogenesis which is a tissue-affinitive Type I collagen obtained from animals characterized by a tyrosine content of 1.5 residues/1000 residues or less, a minimum serine content of 10.0 residues/1000 residues, an isoelectric point of 7 or higher, and which is substantially free of aggregates.
- 2. A process for producing a tissue-affinitive collagen for use as a carrier of bone morphogenic protein for osteogenesis which is a tissue-affinitive Type I collagen obtained from animals, characterized by a tyrosine content of 1.5 residues/1000 residues or less, an isoelectric point of 7 or higher, and which is substantially free of aggregates which process comprises removing aggregates from solubilized collagen by filtration and subjecting the obtained collagen to the action of proteolytic enzymes after filtration and subsequently deactivating the proteolytic enzymes.
- 3. A process according to claim 2, wherein the collagen is subjected to the action of proteolytic enzymes at a temperature below the inactivation temperature of said enzyme and the denaturation temperature of said collagen.
Priority Claims (1)
Number |
Date |
Country |
Kind |
60-136375 |
Jun 1985 |
JPX |
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Parent Case Info
This application is a continuation of application Ser. No. 876,636, filed June 20, 1986, now abandoned.
US Referenced Citations (4)
Foreign Referenced Citations (6)
Number |
Date |
Country |
0132979 |
Feb 1985 |
EPX |
2564732 |
Nov 1985 |
EPX |
0182483 |
May 1986 |
EPX |
0121976 |
Jul 1986 |
EPX |
3147727 |
Dec 1980 |
DEX |
2164042 |
Mar 1986 |
GBX |
Non-Patent Literature Citations (3)
Entry |
Chemical Abstracts vol. 93, 1980 No. 21, Nov. 24 p. 431 Abstract 903:201706d Yasui et al. |
Physicochemical Characterization and Molecular Organization of of the Collagen A and B Chains, R. Kent Rhodes and Edward J. Miller 1978 American Chemical Society. |
Die Angewandle Makromolekulare Chemie 111 (1983) 107-122 (NR. 1701), Collagen Heterogeneity and its Functional Significance, M. Z. Abedin and R. Riemschneider. |
Continuations (1)
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Number |
Date |
Country |
Parent |
876636 |
Jun 1986 |
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