Patent Application
20230391482
The present invention is directed to the distribution of pills. More specifically, the present disclosure is concerned with a system for automatic filling of medication organizers.
Doses of medication over prescribed periods vary as a function of the type of medication and the condition of the patient. Patients are often required to take a plurality of doses over different periods of a day, and this often leads to confusion. It may be difficult for a patient to respect the prescription details (e.g., intake time, quantity) when the doses and the types of medication are numerous.
One well known method used by pharmacists to overcome this problem is to provide the patient with a dose pack having an array of receptacles, with each receptacle corresponding to a particular time of a day at which medication is to be taken. Such packs typically contain four receptacles per day for seven days, and these receptacles are in the form of sealed cups filled with appropriate medication by pharmacists as a function of the prescription, as determined by physicians' prescription. Some types of these dose packs are known as “blister packs” or “blister cards,” which typically include a plurality of wells or pockets arranged in a grid of rows and columns; for many blister cards, a row of wells may represent the medications taken at different times on a particular day, with each row representing a different day. Exemplary blister cards may have seven rows, such that the card represents a week's worth of medications for the patient. Alternative arrangements include 4×8 and 5×7 cards. Another alternative is a 28 or 31 day card, wherein a set of three or four such cards may represent a month's worth of medications, with each card providing medications for a particular time of day (e.g., one “breakfast” card, one “lunch” card, etc.). Also, some blister cards may be oriented 90 degrees from this arrangement, such that the columns represent different days.
The process of preparing these dose packs by hand can be labor-intensive, in that each receptacle must be filled individually. Therefore, although the dose pack facilitates the intake of medication by patients, a substantial amount of time is required to fill these packs by pharmacists.
As a result, automated systems for filling dose packs have been developed. For example, U.S. Pat. No. 8,230,662 B2 to Boutin (the disclosure of which is hereby incorporated herein by reference in full) describes a system for filling medication dose packs with oral-solid medication items. The system (sold under the name SynMed™ XF by Synergie Medicale, Quebec, Canada) comprises storage tray drawers, each of which has multiple storage trays or canisters. Each storage tray stores a specific type of oral solid medication item. The storage tray drawers are displaceable to a drawn position to expose the storage trays thereof. A table supports dosepacks having a plurality of receptacles arranged in rows, with each receptacle associated with an intake time and date of a patient prescription file. A dispensing mechanism, provided with an output arm is displaceable along the axes X, Y and Z in order to transport medication items from the medication storage trays to the dose packs. The dispensing mechanism includes individual pipettes that, via suction, lift individual pills from storage canisters and deposit them into dose packs residing on the table. Another variation of the system is shown in U.S. Patent Publication No. 2020/0016039 to Boutin, the disclosure of which is also incorporated by reference herein in full, a version of which is sold under the name SynMed™ Ultra.
U.S. Provisional Patent Application Nos. 63/226,383 and 63/282,780 discuss trays that are employed with dose packs such as blister cards to receive manually-loaded pills (and in some instances may indicate, via LEDS or the like, whether a pill has been properly deposited). The trays overlie blister cards and have holes that mimic the arrangement of the wells of the blister card. The blister cards are filled through the holes in the trays, then are transported to a second location, where they can be sealed and further processed.
One potential issue with the system discussed in U.S. Pat. No. 8,230,662, supra, and other automated blister card systems (and even some manual filling systems) is a tendency for pills deposited by the pipettes to “bounce” or “rebound” from the wells of the blister cards after being dropped by the pipettes. Clearly, if a pill rebounds from, and therefore does not remain within, the correct well, this error must be addressed (typically manually) after the card is filled. For some combinations of blister cards and pills, as many as 60 or 70 percent of blister cards filled by the system require manual correction, which clearly negatively impacts the productivity of the system. As such, it may be desirable to provide a system that can reduce, if not eliminate entirely, rebounding pills.
As a first aspect, embodiments of the invention are directed to a tray for facilitating the dispensing of pharmaceuticals. The tray comprises: a generally planar main panel; and a plurality of receiving apertures arranged in a grid of rows and columns. A side wall lines each of the receiving apertures. The side wall comprises a receiving segment and a capture segment, the capture segment opposed to the receiving segment, wherein the receiving segment is positioned directly beneath the receiving aperture and defines a receiving angle relative to the main panel, the receiving angle being between about 30 and 70 degrees.
As a second aspect, embodiments of the invention are directed to a pharmaceutical package filling machine comprising: a plurality of containers, each containing pharmaceutical tablets; a support surface configured to support a blister card; a dispensing tool configured to convey tablets from a container to a blister card supported by the support surface; and a tray configured to overlie the blister card supported by the support surface. The tray comprises: a generally planar main panel that overlies the blister card; and a plurality of receiving apertures arranged in a grid of rows and columns corresponding to wells in the blister card. A side wall lines each of the receiving apertures. The side wall comprises a receiving segment and a capture segment, the capture segment opposed to the receiving segment, wherein the receiving segment is positioned directly beneath the receiving aperture and defines a receiving angle relative to the main panel, the receiving angle being between about 30 and 70 degrees.
As a third aspect, embodiments of the invention are directed to a tray for facilitating the dispensing of pharmaceuticals comprising: a generally planar main panel; and a plurality of receiving apertures arranged in a grid of rows and columns. A side wall lines each of the receiving apertures. The side wall comprises a receiving segment and a capture segment, the capture segment opposed to the receiving segment, wherein the receiving segment is positioned directly beneath the receiving aperture and defines a receiving angle relative to the main panel, the receiving angle being between about 40 and 50 degrees, and wherein the capture segment is below but not directly beneath the receiving aperture and defines a capture angle relative to the main panel, the capture angle being between about 95 and 120 degrees.
The present invention will now be described more fully hereinafter, in which preferred embodiments of the invention are shown. This invention may, however, be embodied in different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the invention to those skilled in the art. In the drawings, like numbers refer to like elements throughout. Thicknesses and dimensions of some components may be exaggerated for clarity.
Unless otherwise defined, all terms (including technical and scientific terms) used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. It will be further understood that terms, such as those defined in commonly used dictionaries, should be interpreted as having a meaning that is consistent with their meaning in the context of the relevant art and will not be interpreted in an idealized or overly formal sense unless expressly so defined herein.
The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the singular forms “a”, “an” and “the” are intended to include the plural forms as well, unless the context clearly indicates otherwise. It will be further understood that the terms “comprises” and/or “comprising,” when used in this specification, specify the presence of stated features, integers, steps, operations, elements, and/or components, but do not preclude the presence or addition of one or more other features, integers, steps, operations, elements, components, and/or groups thereof. As used herein the expression “and/or” includes any and all combinations of one or more of the associated listed items.
In addition, spatially relative terms, such as “under”, “below”, “lower”, “over”, “upper” and the like, may be used herein for ease of description to describe one element or feature's relationship to another element(s) or feature(s) as illustrated in the figures. It will be understood that the spatially relative terms are intended to encompass different orientations of the device in use or operation in addition to the orientation depicted in the figures. For example, if the device in the figures is turned over, elements described as “under” or “beneath” other elements or features would then be oriented “over” the other elements or features. Thus, the exemplary term “under” can encompass both an orientation of over and under. The device may be otherwise oriented (rotated 90 degrees or at other orientations) and the spatially relative descriptors used herein interpreted accordingly.
As used herein, the term “forward” and derivatives thereof refer to the general direction vial carriers and vials travel as they move from station to station; this term is intended to be synonymous with the term “downstream”, which is often used in manufacturing environments to indicate that certain material being acted upon is farther along in the manufacturing process than other material. Conversely, the terms “rearward” and “upstream” and derivatives thereof refer to the directions opposite, respectively, the forward and downstream directions.
Well-known functions or constructions may not be described in detail for brevity and/or clarity.
Referring now to the drawings, a system for filling pharmaceutical blister cards is shown in
In summary, containers 14, including different solid oral medications, are stored in the container storage unit 12 and a plurality of empty blister cards 24 are arranged in predetermined positions on the support tables 22 of the filling units 20. The container handling system retrieves one by one in the storage unit 12 the containers 14 corresponding to medications that need to be filled in the blister cards 24 according to patient prescription profiles inputted in the system 10. The container handling system moves each container 14 to a selected one of the two medication organizer filling units 20, which fills the blister cards 24 according to the patient prescription profile.
The above-listed components are contained in an enclosure 30 that includes windows 32, doors 36, drawers 40 and openings 42 that allows visualizing the operation of the system 10 and accessing some of the components of the system 10 for maintenance or replenishing thereof as will be described hereinbelow in more detail.
With reference to
A carriage 50 is mounted to the second support beam 48, and is displaceable along direction Y with respect to the second support beam 48. The tool head 44 is fixedly mounted to the carriage 50 so as to be supported therefrom. An actuator 52 is provided for the independent actuation of the tool head 44 with respect to a remainder of the filling unit 20. Accordingly, there are two degrees of actuation for the tool 26 in the vertical direction. According to the illustrated embodiment, the actuator 52 is a linear actuator providing an additional translational degree of actuation along the Z axis. This linear actuator is preferably used for the capsule-grasping movements of the tool head 44. In such a case, the actuator 52 is advantageously smaller and more power-efficient than the linear actuators of the vertical posts 47, considering the numerous displacements to be performed by the tool head 44.
The tool head 44 has two rows of seven fingers 54, 54′ (see
Referring still to
The fingers 54 are freely mounted onto the support rack 58 so as to be displaceable vertically, while being pulled downwardly by the effect of gravity. With reference to
Referring now to
A grid of receiving apertures 110 is present on the main body 102. The receiving apertures 110 are generally oblong or oval in shape and are arranged to match the grid pattern of a blister card 24 that underlies the tray 100 in use. In this embodiment of the tray, each of the receiving apertures 110 is lined about its perimeter with side walls 112 that extend downwardly from the main body 102 at an angle that is substantially normal to the main body 102. The side walls 112 help to guide a pill dispensed by the system 10 into a well of a blister card 24 that underlies the tray 100 and to prevent pills from slipping out between the main body 102 and the upper edges of the well and/or rebounding from the well. The receiving apertures 110 may be of any configuration that substantially matches the shape of the wells of the underlying blister card 24. As one example, a receiving aperture 110 may be 0.725 inches in width, 1.208 inches in length, and have generally semicircular ends.
In some embodiments, the tray 100 may have indicators (e.g., LEDs or the like) mounted on the main panel adjacent the receiving apertures 110 to indicate the status of the corresponding well of the blister card 24 underlying the tray 100. For example, the indicator may illuminate when a well is to be filled, display a second, different color when the well is filled, blink if dispensing is unsuccessful, etc. The tray 100 may, in some instances, be used for manual loading of a blister card, or may be used for partial manual loading that precedes automated loading. As an example of the latter, a less frequently dispensed drug (i.e., one that is not frequently dispensed enough to be used in the system 10) may be hand loaded into a blister card (aided by the tray 100), then placed in the system for automated loading as described below.
As described above, when the tray 100 is used in conjunction with the system 10, in some instances pills dropped from a finger 54 through a receiving aperture 110 will strike the floor of the well of the blister card 24 and rebound out of the well and the receiving aperture 110. This can occur with sufficient frequency as to negatively impact productivity, because each rebounding pill must be replaced manually after filling of the rest of the blister card 24 is complete, and because the frequency of rebounds, manual checking and some re-loading of the blister card may be required after initial loading.
A tray that can address this issue is shown in
As shown in
It should be noted that the overall visible “footprint” of each of the receiving apertures 210 is the same as that of the receiving apertures 110 of the tray 100. This provides a similar sized and shaped opening for the pills as the fingers 54 drop the pills into the wells of the blister card. An exemplary width for the receiving apertures is between about 0.6 and 0.8 inch, an exemplary length is between about 0.8 and 1 inch, and an exemplary depth is between about 0.25 and 0.5 inch. It may be beneficial in some embodiments for the finger to target the receiving segment 212a of a receiving aperture 210 as the pill is being dropped (i.e., the drop target is offset from the center of the receiving aperture 210 toward the receiving segment 212a); this may be in contrast to the use of a conventional tray 100 as described above, as typically the center of the receiving aperture 110 is targeted by a finger 54 dropping a pill.
Those of skill in this art will appreciate that, although the side wall 212 is shown as being continuous, in some embodiments the side wall may be discontinuous, or may have slots or recesses in certain areas (e.g., at the rounded ends).
Experimentation has shown that use of a tray 200 can significantly reduce, or even eliminate entirely, pills rebounding from blister cards. Results from such experimentation are discussed below in the non-limiting examples.
Experiments on pill rebound were conducted. A pill dispensing system, available from Syngerie Medicale (Quebec, Canada), sold under the trade name SYNMED™ XF and operating in a manner similar to that shown at 10 herein, was used to dispense pills into blister cards via an overlying tray. As a control, either no tray or a tray such as that identified above at 100 was employed. Experimental trays were employed that included receiving apertures with an angled receiving segment and an angled capture segment as described above at 200. The cross-section of receiving aperture 212 is shown in
A Unidose blister card (available from Jones Healthcare) was employed during the experiments, as this card variety had proven in the past to be particularly susceptible to rebounding pills. Also, initially an aspirin pill was dispensed during the experiments; the pill is a round disk of 8.5 mm diameter, and had proven in the past to be particularly susceptible to rebounding.
During the experiments, any tray employed (either the control tray or an experimental tray) was overlaid on a blister card, the card and tray were positioned in the normal operational position within the system, and the pills were dispensed by the system in the typical manner. Each tray included 31 receiving apertures corresponding to the 31 wells in the blister card. The drop height of pills was also varied between experiments by 0.25 inch to simulate different conditions experienced by the SYNMED XF system. For control trays 110, the pill was dropped in the center of the receiving aperture 110. For experimental trays 210, the position of the pill drop was offset from the center of the receiving aperture 210 in a direction toward the receiving surface 212a (Z-offset—see
The dispensing of each pill was recorded with video. Dispensed pills were identified as being in one of four categories: (a) rebounded out of the well; (b) significant rebound, but ended up in the well (indicating a significant chance of rebounding out of the well); (c) some rebound but remained in the well (indicating a moderate chance of rebounding out of the well); and (d) no rebound. Multiple cards (each having 31 wells) were filled during the experiments.
The results from the experiments described in Example 1 are set forth in the chart of
Test Nos. 3 and 4 show results of experiments conducted on trays in which the drop position (Z-offset) was varied from the 0.25″ offset of Test No. 5. It can be seen that an offset of 0.25″ (which corresponds to the target position T shown in
Test No. 6 shows results of experiments in which the pill drop height was varied. The experimental trays 200 as shown in
Finally, Test Nos. 7-10 show results of experiments using different pills. Pill number 2 is an oblong pill having dimensions of 22 mm×8 mm, and Pill number 3 is a disk-shaped pill having an 11.5 mm diameter. The experimental tray 200 continued to exhibit little to any rebounding with these different pills.
The foregoing is illustrative of the present invention and is not to be construed as limiting thereof. Although a few exemplary embodiments of this invention have been described, those skilled in the art will readily appreciate that many modifications are possible in the exemplary embodiments without materially departing from the novel teachings and advantages of this invention. Accordingly, all such modifications are intended to be included within the scope of this invention as defined in the claims. The invention is defined by the following claims, with equivalents of the claims to be included therein.
The present application claims priority from and the benefit of U.S. Provisional Patent Application No. 63/348,321, filed Jun. 2, 2022, the disclosure of which is hereby incorporated herein by reference in full.
| Number | Date | Country | |
|---|---|---|---|
| 63348321 | Jun 2022 | US |
