USE OF ADENO-ASSOCIATED VIRAL VECTORS TO CORRECT GENE DEFECTS/ EXPRESS PROTEINS IN HAIR CELLS AND SUPPORTING CELLS IN THE INNER EAR

TECHNICAL FIELD

The present disclosure relates generally to the use of nucleic acids to treat hearing loss in a primate.

BACKGROUND OF THE INVENTION

Hearing loss can be conductive (arising from the ear canal or middle ear), sensorineural (arising from the inner ear or auditory nerve), or mixed. Most forms of non-syndromic deafness are associated with permanent hearing loss caused by damage to structures in the inner ear (sensorineural deafness), although some forms may involve changes in the middle ear (conductive hearing loss). The great majority of human sensorineural hearing loss is caused by abnormalities in the hair cells of the organ of Corti in the cochlea (poor hair cell function). The hair cells may be abnormal at birth, or may be damaged during the lifetime of an individual (e.g., as a result of noise trauma or infection).

SUMMARY

The present invention is based on the discovery that a composition including at least two different nucleic acid vectors, wherein: each of the at least two different adeno-associated virus (AAV) vectors includes a coding sequence that encodes a different portion of a supporting cell target protein, each of the encoded portions being at least 30 amino acid residues in length, wherein the amino acid sequence of each of the encoded portions may optionally partially overlap with the amino acid sequence of a different one of the encoded portions; no single vector of the at least two different vectors encodes the full-length supporting cell target protein; at least one of the coding sequences includes a nucleotide sequence spanning two neighboring exons of the supporting cell target genomic DNA, and lacks an intronic sequence between the two neighboring exons; and when introduced into a primate cell the at least two different vectors undergo concatamerization or homologous recombination with each other, thereby forming a recombined nucleic acid that encodes a full-length supporting cell target protein.

Provided herein are compositions that include at least two different nucleic acid vectors, where: each of the at least two different adeno-associated virus (AAV) vectors includes a coding sequence that encodes a different portion of a supporting cell target protein, each of the encoded portions being at least 30 amino acid residues in length, where the amino acid sequence of each of the encoded portions may optionally partially overlap with the amino acid sequence of a different one of the encoded portions; no single vector of the at least two different vectors encodes the full-length supporting cell target protein; at least one of the coding sequences includes a nucleotide sequence spanning two neighboring exons of the supporting cell target genomic DNA, and lacks an intronic sequence between the two neighboring exons; and when introduced into a primate cell the at least two different vectors undergo concatamerization or homologous recombination with each other, thereby forming a recombined nucleic acid that encodes a full-length supporting cell target protein.

In some embodiments of any of the compositions described herein, each of the at least two different vectors includes a different segment of an intron, where the intron includes the nucleotide sequence of an intron that is present in a supporting cell target genomic DNA, and where the two different segments overlap in sequence by at least 100 nucleotides. In some embodiments of any of the compositions described herein, the two different segments overlap in sequence by about 30 nucleotides to about 390 nucleotides.

In some embodiments of any of the compositions described herein, the nucleotide sequence of each of the at least two different vectors is between about 30 nucleotides to about 390 nucleotides in length. In some embodiments of any of the compositions described herein, the nucleotide sequence of each of the at least two different vectors is between 30 nucleotides to 340 nucleotides in length.

In some embodiments of any of the compositions described herein, the number of different vectors in the composition is two. In some embodiments of any of the compositions described herein, a first of the two different vectors includes a coding sequence that encodes an N-terminal portion of the supporting cell target protein. In some embodiments of any of the compositions described herein, the N-terminal portion of the supporting cell target protein is between about 30 amino acids to about 390 amino acids in length. In some embodiments of any of the compositions described herein, the N-terminal portion of the supporting cell target protein is between about 30 amino acids to about 340 amino acids in length. In some embodiments of any of the compositions described herein, the first vector further includes one or both of a promoter and a Kozak sequence. In some embodiments of any of the compositions described herein, the first vector includes a promoter that is an inducible promoter, a constitutive promoter, or a tissue-specific promoter.

In some embodiments of any of the compositions described herein, the second of the two different vectors includes a coding sequence that encodes a C-terminal portion of the supporting cell target protein. In some embodiments of any of the compositions described herein, the C-terminal portion of the supporting cell target protein is between 30 amino acids to about 390 amino acids in length. In some embodiments of any of the compositions described herein, the C-terminal portion of the supporting cell target protein is between 30 amino acids to about 340 amino acids in length. In some embodiments of any of the compositions described herein, the second vector further includes a poly(dA) sequence.

Also provided herein are compositions that include two different nucleic acid vectors, where: a first nucleic acid vector of the two different nucleic acid vectors includes a promoter, a first coding sequence that encodes an N-terminal portion of a supporting cell target protein positioned 3′ of the promoter, and a splicing donor signal sequence positioned at the 3′ end of the first coding sequence; and a second nucleic acid vector of the two different nucleic acid vectors includes a splicing acceptor signal sequence, a second coding sequence that encodes a C-terminal portion of a supporting cell target protein positioned at the 3′ end of the splicing acceptor signal sequence, and a polyadenylation sequence at the 3′ end of the second coding sequence; where each of the encoded portions is at least 30 amino acid residues in length, where the amino acid sequences of the encoded portions do not overlap, where no single vector of the two different vectors encodes the full-length supporting cell target protein, and, when the coding sequences are transcribed in a primate cell, to produce RNA transcripts, splicing occurs between the splicing donor signal sequence on one transcript and the splicing acceptor signal sequence on the other transcript, thereby forming a recombined RNA molecule that encodes a full-length supporting cell target protein.

Also provided herein are compositions that include: a first nucleic acid vector including a promoter, a first coding sequence that encodes an N-terminal portion of a supporting cell target protein positioned 3′ of the promoter, a splicing donor signal sequence positioned at the 3′ end of the first coding sequence, and a first detectable marker gene positioned 3′ of the splicing donor signal sequence; and a second nucleic acid vector, different from the first nucleic acid vector, including a second detectable marker gene, a splicing acceptor signal sequence positioned 3′ of the second detectable marker gene, a second coding sequence that encodes a C-terminal portion of a supporting cell target protein positioned at the 3′ end of the splicing acceptor signal sequence, and a polyadenylation sequence positioned at the 3′ end of the second coding sequence; where each of the encoded portions is at least 30 amino acid residues in length, where the respective amino acid sequences of the encoded portions do not overlap with each other, where no single vector of the two different vectors encodes the full-length supporting cell target protein, and, when the coding sequences are transcribed in a primate cell to produce RNA transcripts, splicing occurs between the splicing donor signal on one transcript and the splicing acceptor signal on the other transcript, thereby forming a recombined RNA molecule that encodes a full-length supporting cell target protein.

In some embodiments of any of the compositions described herein, at least one of the coding sequences includes a nucleotide sequence spanning two neighboring exons of a supporting cell target genomic DNA, and lacks an intronic sequence between the neighboring exons. In some embodiments of any of the compositions described herein, the first or second detectable marker gene is alkaline phosphatase. In some embodiments of any of the compositions described herein, the first and second detectable marker genes are the same.

Also provided herein are compositions that include: a first nucleic acid vector including a promoter, a first coding sequence that encodes an N-terminal portion of a supporting cell target protein positioned 3′ to the promoter, a splicing donor signal sequence positioned at the 3′ end of the first coding sequence, and a F1 phage recombinogenic region positioned 3′ to the splicing donor signal sequence; and a second nucleic acid vector, different from the first nucleic acid vector, including a second F1 phage recombinogenic region, a splicing acceptor signal sequence positioned 3′ of the second F1 phage recombinogenic region, a second coding sequence that encodes a C-terminal portion of a supporting cell target protein positioned at the 3′ end of the splicing acceptor signal sequence, and a polyadenylation sequence positioned at the 3′ end of the second coding sequence; where each of the encoded portions is at least 30 amino acid residues in length, where the respective amino acid sequences of the encoded portions do not overlap with each other, where no single vector of the two different vectors encodes the full-length supporting cell target protein, and, when the coding sequences are transcribed in a primate cell to produce RNA transcripts, splicing occurs between the splicing donor signal one transcript and the splicing acceptor signal on the other transcript, thereby forming a recombined RNA molecule that encodes a full-length supporting cell target protein.

Also provided herein are compositions that include a single adeno-associated virus (AAV) vector, where the single AAV vector that includes a nucleic acid sequence that encodes a supporting cell target protein; and when introduced into a primate cell, a nucleic acid encoding a full-length supporting cell target protein is generated at the locus of the supporting cell target gene, and the primate expresses the supporting cell target protein.

In some embodiments of any of the compositions described herein, the supporting cell target gene is gap junction protein beta 2 (GJB2). In some embodiments of any of the compositions described herein, the supporting cell target gene is solute carrier family 26 member 4 (SLC26A4).

In some embodiments of any of the compositions described herein, the composition further includes a pharmaceutically acceptable excipient.

In some embodiments of any of the compositions described herein, the second nucleic acid vector further includes a destabilizing sequence.

In some embodiments of any of the compositions described herein, the second nucleic acid vector further includes a FKBP12 destabilizing sequence.

Also provided herein are kits including any of the compositions described herein. In some embodiments of any of the kits described herein, the kit further includes a pre-loaded syringe containing the composition.

Also provided herein are methods of correcting a supporting cell target gene defect in a supporting cell of an inner ear in a primate that include: administering to the inner ear of the primate a therapeutically effective amount of any of the compositions described herein, where the administering repairs the supporting cell target gene defect in the supporting cell of the inner ear of the primate.

Also provided herein are methods of increasing the expression level of a supporting cell target protein in a supporting cell of an inner ear of a primate that include: administering to the inner ear of the primate a therapeutically effective amount of any of the compositions described herein, where the administering results in an increase in the expression level of the supporting cell target protein in the supporting cell of the inner ear of the primate.

In some embodiments of any of the methods described herein, the primate has previously been determined to have a defective supporting cell target gene.

Also provided herein are methods of treating non-syndromic sensorineural hearing loss in a primate identified as having a defective supporting cell target gene that include: administering to the inner ear of the primate a therapeutically effective amount of any of the compositions described herein.

In some embodiments of any of the methods described herein, the method further includes, prior to the administering step, determining that the primate has a defective supporting cell target gene.

Also provided herein are methods of restoring hearing in a primate identified or diagnosed as having hearing loss that include: administering to the inner ear of the primate a therapeutically effective amount of any composition described herein.

In some embodiments of any of the methods described herein, the method further includes prior to the administering step, determining that the primate has a defective supporting cell target gene.

Also provided herein are methods of restoring synapses and/or preserving spiral ganglion nerves in a primate identified or diagnosed as having an inner ear disorder that include: administering to the inner ear of the primate a therapeutically effective amount of any composition described herein.

In some embodiments of any of the methods described herein, the method further includes prior to the administering step, determining that the primate has a defective supporting cell target gene.

Also provided herein are methods including administering to an inner ear of a primate a therapeutically effective amount of any composition described herein.

In some embodiments of any of the methods described herein, the primate has been previously identified as having a defective supporting cell target gene.

Also provided herein are compositions including at least two different nucleic acid vectors, wherein: each of the at least two different adeno-associated virus (AAV) vectors includes a coding sequence that encodes a different portion of a hair cell target protein, each of the encoded portions being at least 30 amino acid residues in length, wherein the amino acid sequence of each of the encoded portions may optionally partially overlap with the amino acid sequence of a different one of the encoded portions; no single vector of the at least two different vectors encodes the full-length hair cell target protein; at least one of the coding sequences includes a nucleotide sequence spanning two neighboring exons of the hair cell target genomic DNA, and lacks an intronic sequence between the two neighboring exons; and when introduced into a primate cell the at least two different vectors undergo concatamerization or homologous recombination with each other, thereby forming a recombined nucleic acid that encodes a full-length hair cell target protein.

Provided herein are compositions that include at least two different nucleic acid vectors, where: each of the at least two different adeno-associated virus (AAV) vectors includes a coding sequence that encodes a different portion of a hair cell target protein, each of the encoded portions being at least 30 amino acid residues in length, where the amino acid sequence of each of the encoded portions may optionally partially overlap with the amino acid sequence of a different one of the encoded portions; no single vector of the at least two different vectors encodes the full-length protein; at least one of the coding sequences includes a nucleotide sequence spanning two neighboring exons of the hair cell target genomic DNA, and lacks an intronic sequence between the two neighboring exons; and when introduced into a primate cell the at least two different vectors undergo concatamerization or homologous recombination with each other, thereby forming a recombined nucleic acid that encodes a full-length hair cell target protein.

In some embodiments of any of the compositions described herein, the amino acid sequence of one of the encoded portions overlaps with the amino acid sequence of a different one of the encoded portions. In some embodiments of any of the compositions described herein, the amino acid sequence of each of the encoded portions partially overlaps with the amino acid sequence of a different encoded portion. In some embodiments of any of the compositions described herein, the overlapping amino acid sequence is between 30 amino acid residues to about 390 amino acid residues in length. In some embodiments of any of the compositions described herein, each of the at least two different vectors includes a different segment of an intron, where the intron includes the nucleotide sequence of an intron that is present in a hair cell target genomic DNA, and where the two different segments overlap in sequence by at least 100 nucleotides. In some embodiments of any of the compositions described herein, the two different segments overlap in sequence by about 30 nucleotides to about 390 nucleotides. In some embodiments of any of the compositions described herein, the nucleotide sequence of each of the at least two different vectors is between about 30 nucleotides to about 390 nucleotides in length. In some embodiments of any of the compositions described herein, the nucleotide sequence of each of the at least two different vectors is between 30 nucleotides to 340 nucleotides in length.

In some embodiments of any of the compositions described herein, the number of different vectors in the composition is two. In some embodiments of any of the compositions described herein, a first of the two different vectors includes a coding sequence that encodes an N-terminal portion of the hair cell target protein. In some embodiments of any of the compositions described herein, the N-terminal portion of the hair cell target protein is between about 30 amino acids to about 390 amino acids in length. In some embodiments of any of the compositions described herein, the N-terminal portion of the hair cell target protein is between about 30 amino acids to about 340 amino acids in length. In some embodiments of any of the compositions described herein, the first vector further includes one or both of a promoter and a Kozak sequence. In some embodiments of any of the compositions described herein, the first vector includes a promoter that is an inducible promoter, a constitutive promoter, or a tissue-specific promoter.

In some embodiments of any of the compositions described herein, the second of the two different vectors includes a coding sequence that encodes a C-terminal portion of the hair cell target protein. In some embodiments of any of the compositions described herein, the C-terminal portion of the hair cell target protein is between 30 amino acids to about 390 amino acids in length. In some embodiments of any of the compositions described herein, the C-terminal portion of the hair cell target protein is between 30 amino acids to about 340 amino acids in length. In some embodiments of any of the compositions described herein, the second vector further includes a poly(dA) sequence.

Also provided herein are compositions that include two different nucleic acid vectors, where: a first nucleic acid vector of the two different nucleic acid vectors includes a promoter, a first coding sequence that encodes an N-terminal portion of a hair cell target protein positioned 3′ of the promoter, and a splicing donor signal sequence positioned at the 3′ end of the first coding sequence; and a second nucleic acid vector of the two different nucleic acid vectors includes a splicing acceptor signal sequence, a second coding sequence that encodes a C-terminal portion of a hair cell target protein positioned at the 3′ end of the splicing acceptor signal sequence, and a polyadenylation sequence at the 3′ end of the second coding sequence; where each of the encoded portions is at least 30 amino acid residues in length, where the amino acid sequences of the encoded portions do not overlap, where no single vector of the two different vectors encodes the full-length hair cell target protein, and, when the coding sequences are transcribed in a primate cell, to produce RNA transcripts, splicing occurs between the splicing donor signal sequence on one transcript and the splicing acceptor signal sequence on the other transcript, thereby forming a recombined RNA molecule that encodes a full-length hair cell target protein.

Also provided herein are compositions that include: a first nucleic acid vector including a promoter, a first coding sequence that encodes an N-terminal portion of a hair cell target protein positioned 3′ of the promoter, a splicing donor signal sequence positioned at the 3′ end of the first coding sequence, and a first detectable marker gene positioned 3′ of the splicing donor signal sequence; and a second nucleic acid vector, different from the first nucleic acid vector, including a second detectable marker gene, a splicing acceptor signal sequence positioned 3′ of the second detectable marker gene, a second coding sequence that encodes a C-terminal portion of a hair cell target protein positioned at the 3′ end of the splicing acceptor signal sequence, and a polyadenylation sequence positioned at the 3′ end of the second coding sequence; where each of the encoded portions is at least 30 amino acid residues in length, where the respective amino acid sequences of the encoded portions do not overlap with each other, where no single vector of the two different vectors encodes the full-length hair cell target protein, and, when the coding sequences are transcribed in a primate cell to produce RNA transcripts, splicing occurs between the splicing donor signal on one transcript and the splicing acceptor signal on the other transcript, thereby forming a recombined RNA molecule that encodes a full-length hair cell target protein.

In some embodiments of any of the compositions described herein, at least one of the coding sequences includes a nucleotide sequence spanning two neighboring exons of a hair cell target genomic DNA, and lacks an intronic sequence between the neighboring exons. In some embodiments of any of the compositions described herein, the first or second detectable marker gene is alkaline phosphatase. In some embodiments of any of the compositions described herein, the first and second detectable marker genes are the same.

Also provided herein are compositions that include: a first nucleic acid vector including a promoter, a first coding sequence that encodes an N-terminal portion of a hair cell target protein positioned 3′ to the promoter, a splicing donor signal sequence positioned at the 3′ end of the first coding sequence, and a F1 phage recombinogenic region positioned 3′ to the splicing donor signal sequence; and a second nucleic acid vector, different from the first nucleic acid vector, including a second F1 phage recombinogenic region, a splicing acceptor signal sequence positioned 3′ of the second F1 phage recombinogenic region, a second coding sequence that encodes a C-terminal portion of a hair cell target protein positioned at the 3′ end of the splicing acceptor signal sequence, and a polyadenylation sequence positioned at the 3′ end of the second coding sequence; where each of the encoded portions is at least 30 amino acid residues in length, where the respective amino acid sequences of the encoded portions do not overlap with each other, where no single vector of the two different vectors encodes the full-length hair cell target protein, and, when the coding sequences are transcribed in a primate cell to produce RNA transcripts, splicing occurs between the splicing donor signal one transcript and the splicing acceptor signal on the other transcript, thereby forming a recombined RNA molecule that encodes a full-length hair cell target protein.

Also provided herein are compositions that include a single adeno-associated virus (AAV) vector, where the single AAV vector that includes a nucleic acid sequence that encodes a hair cell target protein; and when introduced into a primate cell, a nucleic acid encoding a full-length hair cell target protein is generated at the locus of the hair cell target gene, and the primate expresses the hair cell target protein.

In some embodiments of any of the compositions described herein, the composition further includes a pharmaceutically acceptable excipient.

Also provided herein are methods of correcting a hair cell target gene defect in a hair cell of an inner ear in a primate that include: administering to the inner ear of the primate a therapeutically effective amount of any of the compositions described herein, where the administering repairs the hair cell target gene defect in the hair cell of the inner ear of the primate.

Also provided herein are methods of increasing the expression level of a hair cell target protein in a hair cell of an inner ear of a primate that include: administering to the inner ear of the primate a therapeutically effective amount of any of the compositions described herein, where the administering results in an increase in the expression level of the hair cell target protein in the hair cell of the inner ear of the primate.

In some embodiments of any of the methods described herein, the primate has previously been determined to have a defective hair cell target gene.

Also provided herein are methods of treating non-syndromic sensorineural hearing loss in a primate identified as having a defective hair cell target gene that include: administering to the inner ear of the primate a therapeutically effective amount of any of the compositions described herein.

In some embodiments of any of the methods described herein, the method further includes, prior to the administering step, determining that the primate has a defective hair cell target gene.

In some embodiments of any of the methods described herein, the method further includes prior to the administering step, determining that the primate has a defective hair cell target gene.

Also provided herein are methods including administering to an inner ear of a primate a therapeutically effective amount of any composition described herein.

In some embodiments of any of the methods described herein, the primate has been previously identified as having a defective hair cell target gene.

The term “a” and “an” refers to one or to more than one (i.e., at least one) of the grammatical object of the article. By way of example, “an element” encompasses one element and more than one element.

The term “supporting cell target protein” means a protein that is expressed in a supporting cell in a primate and functionally contributes, at least in part, to the hearing in the primate. Non-limiting examples of supporting cell target proteins include GJB2 and SLC26A4.

The term “mutation in a supporting cell target gene” refers to a modification in a wildtype supporting cell target gene that results in the production of a supporting cell target protein having one or more of: a deletion in one or more amino acids, one or more amino acid substitutions, and one or more amino acid insertions as compared to the wildtype supporting cell target protein, and/or results in a decrease in the expressed level of the encoded supporting cell target protein in a primate cell as compared to the expressed level of the encoded supporting cell target protein in a primate cell not having a mutation. In some embodiments, a mutation can result in the production of a supporting cell target protein having a deletion in one or more amino acids (e.g., 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15 16, 17, 18, 19, or 20 amino acids). In some embodiments, the mutation can result in a frameshift in the supporting cell target gene.

The term “hair cell target protein” means a protein that is expressed in a hair cell in a primate and functionally contributes, at least in part, to the hearing in the primate.

Non-limiting examples of hair cell target proteins include tectorin alpha (TECTA), unconventional myson-15 (MYO15A), myosin IIIA (MYO3A), myosin VI (MYO6), myosin VIIA (MYO7A), cadherin related 23 (CDH23), collagen type XI alpha 2 chain (COL11A2), lipoxygenase homology domains 1 (LOXHD1), protocadherin related 15 (PCDH15), whirlin (WIHRN), an otoferlin (OTOF) gene, a trio rho guanine nucleotide exchange factor (TRIO) and f-actin binding protein (TRIOBP) gene, a stereocilin (STRC) gene, a pejvakin (PJVK) gene, a norrin cysteine knot growth factor (NDP) gene, a clarin 1 (CLRN1) gene, a transmembrane channel-like 1 (TMC1) gene, a vascular endothelial growth factor (VEGF) gene, and a heat shock protein family A (Hsp70) member 1A (HSPA1A) gene.

The term “mutation in a hair cell target gene” refers to a modification in a wildtype hair cell target gene that results in the production of a hair cell target protein having one or more of: a deletion in one or more amino acids, one or more amino acid substitutions, and one or more amino acid insertions as compared to the wildtype hair cell target protein, and/or results in a decrease in the expressed level of the encoded hair cell target protein in a primate cell as compared to the expressed level of the encoded hair cell target protein in a primate cell not having a mutation. In some embodiments, a mutation can result in the production of a hair cell target protein having a deletion in one or more amino acids (e.g., 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15 16, 17, 18, 19, or 20 amino acids). In some embodiments, the mutation can result in a frameshift in the hair cell target gene.

The term “frameshift” is known in the art to encompass any mutation in a coding sequence that results in a shift in the reading frame of the coding sequence. In some embodiments, a frameshift can result in a nonfunctional protein. In some embodiments, a point mutation can be a nonsense mutation (i.e., result in a premature stop codon in an exon of the gene). A nonsense mutation can result in the production of a truncated protein (as compared to a corresponding wildtype protein) that may or may not be functional. In some embodiments, the mutation can result in the loss (or a decrease in the level) of expression of hair cell target mRNA or hair cell target protein or both the mRNA and protein. In some embodiments, the mutation can result in the production of an altered hair cell target protein having a loss or decrease in one or more biological activities (functions) as compared to a wildtype hair cell target protein. In some embodiments, the mutation can result in the loss (or a decrease in the level) of expression of supporting cell target mRNA or supporting cell target protein or both the mRNA and protein. In some embodiments, the mutation can result in the production of an altered supporting cell target protein having a loss or decrease in one or more biological activities (functions) as compared to a wildtype supporting cell target protein.

In some embodiments, the mutation is an insertion of one or more nucleotides into a hair cell target gene. In some embodiments, the mutation is in a regulatory sequence of the hair cell target gene, i.e., a portion of the gene that is not coding sequence. In some embodiments, a mutation in a regulatory sequence may be in a promoter or enhancer region and prevent or reduce the proper transcription of the hair cell target gene. In some embodiments, the mutation is an insertion of one or more nucleotides into a supporting cell target gene. In some embodiments, the mutation is in a regulatory sequence of the supporting cell target gene, i.e., a portion of the gene that is not coding sequence. In some embodiments, a mutation in a regulatory sequence may be in a promoter or enhancer region and prevent or reduce the proper transcription of the supporting cell target gene. The term “conservative mutation” refers to a mutation that does not change the amino acid encoded at the site of the mutation (due to codon degeneracy).

Modifications can be introduced into a nucleotide sequence by standard techniques known in the art, such as site-directed mutagenesis and PCR-mediated mutagenesis. Conservative amino acid substitutions are ones in which the amino acid residue is replaced with an amino acid residue having a similar side chain. Families of amino acid residues having similar side chains have been defined in the art. These families include amino acids with basic side chains (e.g., lysine, arginine, and histidine), acidic side chains (e.g., aspartic acid and glutamic acid), uncharged polar side chains (e.g., glycine, asparagine, glutamine, serine, threonine, tyrosine, cysteine, and tryptophan), nonpolar side chains (e.g., alanine, valine, leucine, isoleucine, proline, phenylalanine, and methionine), beta-branched side chains (e.g., threonine, valine, and isoleucine), and aromatic side chains (e.g., tyrosine, phenylalanine, tryptophan, and histidine).

Unless otherwise specified, a “nucleotide sequence encoding an amino acid sequence” includes all nucleotide sequences that are degenerate versions of each other and thus encode the same amino acid sequence.

The term “endogenous” refers to any material originating from within an organism, cell, or tissue.

The term “exogenous” refers to any material introduced from or originating from outside an organism, cell, or tissue that is not produced or does not originate from the same organism, cell, or tissue in which it is being introduced.

The term “isolated” means altered or removed from the natural state. For example, a nucleic acid or a peptide naturally present in a living animal is not “isolated,” but the same nucleic acid or peptide partially or completely separated from the coexisting materials of its natural state is “isolated.” An isolated nucleic acid or protein can exist in substantially purified form, or can exist in a non-native environment such as, for example, a host cell.

The term “transfected,” “transformed,” or “transduced” refers to a process by which exogenous nucleic acid is transferred or introduced into a cell. A “transfected,” “transformed,” or “transduced” primate cell is one that has been transfected, transformed or transduced with exogenous nucleic acid.

The term “expression” refers to the transcription and/or translation of a particular nucleotide sequence encoding a protein.

The term “transient expression” refers to the expression of a non-integrated coding sequence for a short period of time (e.g., hours or days). The coding sequence that is transiently expressed in a cell (e.g., a primate cell) is lost upon multiple rounds of cell division.

The term “primate” is intended to include any primate (e.g., a human, a non-human primate (e.g., simian (e.g., a monkey (e.g., a marmoset, a baboon, or a macaque), or an ape (e.g., a gorilla, a gibbon, an orangutan, or a chimpanzee). In some embodiments, the primate has or is at risk of having hearing loss. In some embodiments, the primate has been previously identified as having a mutation in a hair cell target gene (e.g., an OTOF gene, a TRIOBP gene, a STRC gene, a PJVK gene, a NDP gene, a CLRN1 gene, a TMC1 gene, a VEGF gene, or a HSPA1A gene). In some embodiments, the primate has been previously identified as having a mutation in a supporting cell target gene (e.g., a GJB2 gene or a SLC26A4 gene). In some embodiments, the primate has been previously identified as having a mutation in a GJB2 gene. In some embodiments, the primate has been previously identified as having a mutation in a SLC26A4 gene. In some embodiments, the primate has been identified as having a mutation in a hair cell target gene (e.g., an OTOF gene, a TRIOBP gene, a STRC gene, a PJVK gene, a NDP gene, a CLRN1 gene, a TMC1 gene, a VEGF gene, or a HSPA1A gene) and has been diagnosed with hearing loss. In some embodiments, the primate has been identified as having a mutation in a supporting cell target gene (e.g., a GBJ2 gene or a SLC26A4 gene) and has been diagnosed with hearing loss. In some embodiments, the primate has been identified as having hearing loss.

A treatment is “therapeutically effective” when it results in a reduction in one or more of the number, severity, and frequency of one or more symptoms of a disease state (hearing loss, e.g., non-syndromic sensorineural hearing loss or syndromic sensorineural hearing loss) in a primate. In some embodiments, a therapeutically effective amount of a composition can result in an increase in the expression level of an active target protein (e.g., a supporting cell target protein (e.g., a wildtype, full-length supporting cell target protein or a variant of a supporting cell target protein that has the desired activity) (e.g., as compared to the expression level prior to treatment with the composition) or a hair cell target protein (e.g., a wildtype, full-length hair cell target protein or a variant of a hair cell target protein that has the desired activity) (e.g., as compared to the expression level prior to treatment with the composition)). In some embodiments, a therapeutically effective amount of a composition can result in an increase in the expression level of an active target protein (e.g., an active supporting cell target protein (e.g., a wildtype, full-length supporting cell target protein or active variant) ort an active hair cell target protein (e.g., a wildtype, full-length hair cell target protein or active variant) in a target cell (e.g., a supporting cell or a hair cell). In some embodiments, a therapeutically effective amount of a composition can result in an increase in the expression level of an active target protein (e.g., an active supporting cell target protein (e.g., a wildtype, full-length supporting cell target protein or active variant) or an active hair cell target protein (e.g., a wildtype, full-length hair cell target protein or active variant), and/or an increase in one or more activities of a target protein (e.g., a supporting cell target protein or a hair cell target protein) in a target cell (e.g., as compared to a reference level, such as the level(s) in a primate prior to treatment, the level(s) in a primate having a mutation in a target gene (e.g., a supporting cell target gene or a hair cell target gene), or the level(s) in a primate or a population of primates having hearing loss, e.g., non-syndromic sensorineural hearing loss or syndromic sensorineural hearing loss).

The term “nucleic acid” or “polynucleotide” refers to deoxyribonucleic acid (DNA) or ribonucleic acid (RNA), or a combination thereof, in either single- or double-stranded form. Unless specifically limited, the term encompasses nucleic acids containing known analogues of natural nucleotides that have similar binding properties as the reference nucleotides. Unless otherwise indicated, a particular nucleic acid sequence also implicitly encompasses complementary sequences as well as the sequence explicitly indicated. In some embodiments of any of the nucleic acids described herein, the nucleic acid is DNA. In some embodiments of any of the nucleic acids described herein, the nucleic acid is RNA.

The term “active hair cell target protein” means a protein encoded by DNA that, if substituted for both wildtype alleles encoding full-length hair cell target protein in hair cells of what is otherwise a wildtype primate, and if expressed in the hair cells of that primate, results in that primate's having a level of hearing approximating the normal level of hearing of a similar primate that is entirely wildtype. Non-limiting examples of active hair cell target proteins are full-length hair cell target proteins (e.g., any of the full-length hair cell target proteins described herein).

The term “active supporting cell target protein” means a protein encoded by DNA that, if substituted for both wildtype alleles encoding full-length supporting cell target protein in supporting cells of what is otherwise a wildtype primate, and if expressed in the supporting cells of that primate, results in that primate's having a level of hearing approximating the normal level of hearing of a similar primate that is entirely wildtype. Non-limiting examples of active supporting cell target proteins are full-length supporting cell target proteins (e.g., any of the full-length supporting cell target proteins described herein).

For example, an active target protein (e.g., an active supporting cell target protein or an active hair cell target protein) can include a sequence of a wildtype, full-length target protein (e.g., a supporting cell target protein (e.g., a wildtype, human, full-length supporting cell target protein) or a hair cell target protein (e.g., a wildtype, human, full-length hair cell target protein) including 1 amino acid substitution to about 160 amino acid substitutions, 1 amino acid substitution to about 155 amino acid substitutions, 1 amino acid substitution to about 150 amino acid substitutions, 1 amino acid substitution to about 145 amino acid substitutions, 1 amino acid substitution to about 140 amino acid substitutions, 1 amino acid substitution to about 135 amino acid substitutions, 1 amino acid substitution to about 130 amino acid substitutions, 1 amino acid substitution to about 125 amino acid substitutions, 1 amino acid substitution to about 120 amino acid substitutions, 1 amino acid substitution to about 115 amino acid substitutions, 1 amino acid substitution to about 110 amino acid substitutions, 1 amino acid substitution to about 105 amino acid substitutions, 1 amino acid substitution to about 100 amino acid substitutions, 1 amino acid substitution to about 95 amino acid substitutions, 1 amino acid substitution to about 90 amino acid substitutions, 1 amino acid substitution to about 85 amino acid substitutions, 1 amino acid substitution to about 80 amino acid substitutions, 1 amino acid substitution to about 75 amino acid substitutions, 1 amino acid substitution to about 70 amino acid substitutions, 1 amino acid substitution to about 65 amino acid substitutions, 1 amino acid substitution to about 60 amino acid substitutions, 1 amino acid substitution to about 55 amino acid substitutions, 1 amino acid substitution to about 50 amino acid substitutions, 1 amino acid substitution to about 45 amino acid substitutions, 1 amino acid substitution to about 40 amino acid substitutions, 1 amino acid substitution to about 35 amino acid substitutions, 1 amino acid substitution to about 30 amino acid substitutions, 1 amino acid substitution to about 25 amino acid substitutions, 1 amino acid substitution to about 20 amino acid substitutions, 1 amino acid substitution to about 15 amino acid substitutions, 1 amino acid substitution to about 10 amino acid substitutions, 1 amino acid substitution to about 9 amino acid substitutions, 1 amino acid substitution to about 8 amino acid substitutions, 1 amino acid substitution to about 7 amino acid substitutions, 1 amino acid substitution to about 6 amino acid substitutions, 1 amino acid substitution to about 5 amino acid substitutions, 1 amino acid substitution to about 4 amino acid substitutions, 1 amino acid substitution to about 3 amino acid substitutions, between about 2 amino acid substitutions to about 160 amino acid substitutions, about 2 amino acid substitutions to about 155 amino acid substitutions, about 2 amino acid substitutions to about 150 amino acid substitutions, about 2 amino acid substitutions to about 145 amino acid substitutions, about 2 amino acid substitutions to about 140 amino acid substitutions, about 2 amino acid substitutions to about 135 amino acid substitutions, about 2 amino acid substitutions to about 130 amino acid substitutions, about 2 amino acid substitutions to about 125 amino acid substitutions, about 2 amino acid substitutions to about 120 amino acid substitutions, about 2 amino acid substitutions to about 115 amino acid substitutions, about 2 amino acid substitutions to about 110 amino acid substitutions, about 2 amino acid substitutions to about 105 amino acid substitutions, about 2 amino acid substitutions to about 100 amino acid substitutions, about 2 amino acid substitutions to about 95 amino acid substitutions, about 2 amino acid substitutions to about 90 amino acid substitutions, about 2 amino acid substitutions to about 85 amino acid substitutions, about 2 amino acid substitutions to about 80 amino acid substitutions, about 2 amino acid substitutions to about 75 amino acid substitutions, about 2 amino acid substitutions to about 70 amino acid substitutions, about 2 amino acid substitutions to about 65 amino acid substitutions, about 2 amino acid substitutions to about 60 amino acid substitutions, about 2 amino acid substitutions to about 55 amino acid substitutions, about 2 amino acid substitutions to about 50 amino acid substitutions, about 2 amino acid substitutions to about 45 amino acid substitutions, about 2 amino acid substitutions to about 40 amino acid substitutions, about 2 amino acid substitutions to about 35 amino acid substitutions, about 2 amino acid substitutions to about 30 amino acid substitutions, about 2 amino acid substitutions to about 25 amino acid substitutions, about 2 amino acid substitutions to about 20 amino acid substitutions, about 2 amino acid substitutions to about 15 amino acid substitutions, about 2 amino acid substitutions to about 10 amino acid substitutions, about 2 amino acid substitutions to about 9 amino acid substitutions, about 2 amino acid substitutions to about 8 amino acid substitutions, about 2 amino acid substitutions to about 7 amino acid substitutions, about 2 amino acid substitutions to about 6 amino acid substitutions, about 2 amino acid substitutions to about 5 amino acid substitutions, about 2 amino acid substitutions to about 4 amino acid substitutions, between about 3 amino acid substitutions to about 160 amino acid substitutions, about 3 amino acid substitutions to about 155 amino acid substitutions, about 3 amino acid substitutions to about 150 amino acid substitutions, about 3 amino acid substitutions to about 145 amino acid substitutions, about 3 amino acid substitutions to about 140 amino acid substitutions, about 3 amino acid substitutions to about 135 amino acid substitutions, about 3 amino acid substitutions to about 130 amino acid substitutions, about 3 amino acid substitutions to about 125 amino acid substitutions, about 3 amino acid substitutions to about 120 amino acid substitutions, about 3 amino acid substitutions to about 115 amino acid substitutions, about 3 amino acid substitutions to about 110 amino acid substitutions, about 3 amino acid substitutions to about 105 amino acid substitutions, about 3 amino acid substitutions to about 100 amino acid substitutions, about 3 amino acid substitutions to about 95 amino acid substitutions, about 3 amino acid substitutions to about 90 amino acid substitutions, about 3 amino acid substitutions to about 85 amino acid substitutions, about 3 amino acid substitutions to about 80 amino acid substitutions, about 3 amino acid substitutions to about 75 amino acid substitutions, about 3 amino acid substitutions to about 70 amino acid substitutions, about 3 amino acid substitutions to about 65 amino acid substitutions, about 3 amino acid substitutions to about 60 amino acid substitutions, about 3 amino acid substitutions to about 55 amino acid substitutions, about 3 amino acid substitutions to about 50 amino acid substitutions, about 3 amino acid substitutions to about 45 amino acid substitutions, about 3 amino acid substitutions to about 40 amino acid substitutions, about 3 amino acid substitutions to about 35 amino acid substitutions, about 3 amino acid substitutions to about 30 amino acid substitutions, about 3 amino acid substitutions to about 25 amino acid substitutions, about 3 amino acid substitutions to about 20 amino acid substitutions, about 3 amino acid substitutions to about 15 amino acid substitutions, about 3 amino acid substitutions to about 10 amino acid substitutions, about 3 amino acid substitutions to about 9 amino acid substitutions, about 3 amino acid substitutions to about 8 amino acid substitutions, about 3 amino acid substitutions to about 7 amino acid substitutions, about 3 amino acid substitutions to about 6 amino acid substitutions, about 3 amino acid substitutions to about 5 amino acid substitutions, between about 4 amino acid substitutions to about 160 amino acid substitutions, about 4 amino acid substitutions to about 155 amino acid substitutions, about 4 amino acid substitutions to about 150 amino acid substitutions, about 4 amino acid substitutions to about 145 amino acid substitutions, about 4 amino acid substitutions to about 140 amino acid substitutions, about 4 amino acid substitutions to about 135 amino acid substitutions, about 4 amino acid substitutions to about 130 amino acid substitutions, about 4 amino acid substitutions to about 125 amino acid substitutions, about 4 amino acid substitutions to about 120 amino acid substitutions, about 4 amino acid substitutions to about 115 amino acid substitutions, about 4 amino acid substitutions to about 110 amino acid substitutions, about 4 amino acid substitutions to about 105 amino acid substitutions, about 4 amino acid substitutions to about 100 amino acid substitutions, about 4 amino acid substitutions to about 95 amino acid substitutions, about 4 amino acid substitutions to about 90 amino acid substitutions, about 4 amino acid substitutions to about 85 amino acid substitutions, about 4 amino acid substitutions to about 80 amino acid substitutions, about 4 amino acid substitutions to about 75 amino acid substitutions, about 4 amino acid substitutions to about 70 amino acid substitutions, about 4 amino acid substitutions to about 65 amino acid substitutions, about 4 amino acid substitutions to about 60 amino acid substitutions, about 4 amino acid substitutions to about 55 amino acid substitutions, about 4 amino acid substitutions to about 50 amino acid substitutions, about 4 amino acid substitutions to about 45 amino acid substitutions, about 4 amino acid substitutions to about 40 amino acid substitutions, about 4 amino acid substitutions to about 35 amino acid substitutions, about 4 amino acid substitutions to about 30 amino acid substitutions, about 4 amino acid substitutions to about 25 amino acid substitutions, about 4 amino acid substitutions to about 20 amino acid substitutions, about 4 amino acid substitutions to about 15 amino acid substitutions, about 4 amino acid substitutions to about 10 amino acid substitutions, about 4 amino acid substitutions to about 9 amino acid substitutions, about 4 amino acid substitutions to about 8 amino acid substitutions, about 4 amino acid substitutions to about 7 amino acid substitutions, about 4 amino acid substitutions to about 6 amino acid substitutions, between about 5 amino acid substitutions to about 160 amino acid substitutions, about 5 amino acid substitutions to about 155 amino acid substitutions, about 5 amino acid substitutions to about 150 amino acid substitutions, about 5 amino acid substitutions to about 145 amino acid substitutions, about 5 amino acid substitutions to about 140 amino acid substitutions, about 5 amino acid substitutions to about 135 amino acid substitutions, about 5 amino acid substitutions to about 130 amino acid substitutions, about 5 amino acid substitutions to about 125 amino acid substitutions, about 5 amino acid substitutions to about 120 amino acid substitutions, about 5 amino acid substitutions to about 115 amino acid substitutions, about 5 amino acid substitutions to about 110 amino acid substitutions, about 5 amino acid substitutions to about 105 amino acid substitutions, about 5 amino acid substitutions to about 100 amino acid substitutions, about 5 amino acid substitutions to about 95 amino acid substitutions, about 5 amino acid substitutions to about 90 amino acid substitutions, about 5 amino acid substitutions to about 85 amino acid substitutions, about 5 amino acid substitutions to about 80 amino acid substitutions, about 5 amino acid substitutions to about 75 amino acid substitutions, about 5 amino acid substitutions to about 70 amino acid substitutions, about 5 amino acid substitutions to about 65 amino acid substitutions, about 5 amino acid substitutions to about 60 amino acid substitutions, about 5 amino acid substitutions to about 55 amino acid substitutions, about 5 amino acid substitutions to about 50 amino acid substitutions, about 5 amino acid substitutions to about 45 amino acid substitutions, about 5 amino acid substitutions to about 40 amino acid substitutions, about 5 amino acid substitutions to about 35 amino acid substitutions, about 5 amino acid substitutions to about 30 amino acid substitutions, about 5 amino acid substitutions to about 25 amino acid substitutions, about 5 amino acid substitutions to about 20 amino acid substitutions, about 5 amino acid substitutions to about 15 amino acid substitutions, about 5 amino acid substitutions to about 10 amino acid substitutions, about 5 amino acid substitutions to about 9 amino acid substitutions, about 5 amino acid substitutions to about 8 amino acid substitutions, about 5 amino acid substitutions to about 7 amino acid substitutions, between about 6 amino acid substitutions to about 160 amino acid substitutions, about 6 amino acid substitutions to about 155 amino acid substitutions, about 6 amino acid substitutions to about 150 amino acid substitutions, about 6 amino acid substitutions to about 145 amino acid substitutions, about 6 amino acid substitutions to about 140 amino acid substitutions, about 6 amino acid substitutions to about 135 amino acid substitutions, about 6 amino acid substitutions to about 130 amino acid substitutions, about 6 amino acid substitutions to about 125 amino acid substitutions, about 6 amino acid substitutions to about 120 amino acid substitutions, about 6 amino acid substitutions to about 115 amino acid substitutions, about 6 amino acid substitutions to about 110 amino acid substitutions, about 6 amino acid substitutions to about 105 amino acid substitutions, about 6 amino acid substitutions to about 100 amino acid substitutions, about 6 amino acid substitutions to about 95 amino acid substitutions, about 6 amino acid substitutions to about 90 amino acid substitutions, about 6 amino acid substitutions to about 85 amino acid substitutions, about 6 amino acid substitutions to about 80 amino acid substitutions, about 6 amino acid substitutions to about 75 amino acid substitutions, about 6 amino acid substitutions to about 70 amino acid substitutions, about 6 amino acid substitutions to about 65 amino acid substitutions, about 6 amino acid substitutions to about 60 amino acid substitutions, about 6 amino acid substitutions to about 55 amino acid substitutions, about 6 amino acid substitutions to about 50 amino acid substitutions, about 6 amino acid substitutions to about 45 amino acid substitutions, about 6 amino acid substitutions to about 40 amino acid substitutions, about 6 amino acid substitutions to about 35 amino acid substitutions, about 6 amino acid substitutions to about 30 amino acid substitutions, about 6 amino acid substitutions to about 25 amino acid substitutions, about 6 amino acid substitutions to about 20 amino acid substitutions, about 6 amino acid substitutions to about 15 amino acid substitutions, about 6 amino acid substitutions to about 10 amino acid substitutions, about 6 amino acid substitutions to about 9 amino acid substitutions, about 6 amino acid substitutions to about 8 amino acid substitutions, between about 7 amino acid substitutions to about 160 amino acid substitutions, about 7 amino acid substitutions to about 155 amino acid substitutions, about 7 amino acid substitutions to about 150 amino acid substitutions, about 7 amino acid substitutions to about 145 amino acid substitutions, about 7 amino acid substitutions to about 140 amino acid substitutions, about 7 amino acid substitutions to about 135 amino acid substitutions, about 7 amino acid substitutions to about 130 amino acid substitutions, about 7 amino acid substitutions to about 125 amino acid substitutions, about 7 amino acid substitutions to about 120 amino acid substitutions, about 7 amino acid substitutions to about 115 amino acid substitutions, about 7 amino acid substitutions to about 110 amino acid substitutions, about 7 amino acid substitutions to about 105 amino acid substitutions, about 7 amino acid substitutions to about 100 amino acid substitutions, about 7 amino acid substitutions to about 95 amino acid substitutions, about 7 amino acid substitutions to about 90 amino acid substitutions, about 7 amino acid substitutions to about 85 amino acid substitutions, about 7 amino acid substitutions to about 80 amino acid substitutions, about 7 amino acid substitutions to about 75 amino acid substitutions, about 7 amino acid substitutions to about 70 amino acid substitutions, about 7 amino acid substitutions to about 65 amino acid substitutions, about 7 amino acid substitutions to about 60 amino acid substitutions, about 7 amino acid substitutions to about 55 amino acid substitutions, about 7 amino acid substitutions to about 50 amino acid substitutions, about 7 amino acid substitutions to about 45 amino acid substitutions, about 7 amino acid substitutions to about 40 amino acid substitutions, about 7 amino acid substitutions to about 35 amino acid substitutions, about 7 amino acid substitutions to about 30 amino acid substitutions, about 7 amino acid substitutions to about 25 amino acid substitutions, about 7 amino acid substitutions to about 20 amino acid substitutions, about 7 amino acid substitutions to about 15 amino acid substitutions, about 7 amino acid substitutions to about 10 amino acid substitutions, about 7 amino acid substitutions to about 9 amino acid substitutions, between about 8 amino acid substitutions to about 160 amino acid substitutions, about 8 amino acid substitutions to about 155 amino acid substitutions, about 8 amino acid substitutions to about 150 amino acid substitutions, about 8 amino acid substitutions to about 145 amino acid substitutions, about 8 amino acid substitutions to about 140 amino acid substitutions, about 8 amino acid substitutions to about 135 amino acid substitutions, about 8 amino acid substitutions to about 130 amino acid substitutions, about 8 amino acid substitutions to about 125 amino acid substitutions, about 8 amino acid substitutions to about 120 amino acid substitutions, about 8 amino acid substitutions to about 115 amino acid substitutions, about 8 amino acid substitutions to about 110 amino acid substitutions, about 8 amino acid substitutions to about 105 amino acid substitutions, about 8 amino acid substitutions to about 100 amino acid substitutions, about 8 amino acid substitutions to about 95 amino acid substitutions, about 8 amino acid substitutions to about 90 amino acid substitutions, about 8 amino acid substitutions to about 85 amino acid substitutions, about 8 amino acid substitutions to about 80 amino acid substitutions, about 8 amino acid substitutions to about 75 amino acid substitutions, about 8 amino acid substitutions to about 70 amino acid substitutions, about 8 amino acid substitutions to about 65 amino acid substitutions, about 8 amino acid substitutions to about 60 amino acid substitutions, about 8 amino acid substitutions to about 55 amino acid substitutions, about 8 amino acid substitutions to about 50 amino acid substitutions, about 8 amino acid substitutions to about 45 amino acid substitutions, about 8 amino acid substitutions to about 40 amino acid substitutions, about 8 amino acid substitutions to about 35 amino acid substitutions, about 8 amino acid substitutions to about 30 amino acid substitutions, about 8 amino acid substitutions to about 25 amino acid substitutions, about 8 amino acid substitutions to about 20 amino acid substitutions, about 8 amino acid substitutions to about 15 amino acid substitutions, about 8 amino acid substitutions to about 10 amino acid substitutions, between about 10 amino acid substitutions to about 160 amino acid substitutions, about 10 amino acid substitutions to about 155 amino acid substitutions, about 10 amino acid substitutions to about 150 amino acid substitutions, about 10 amino acid substitutions to about 145 amino acid substitutions, about 10 amino acid substitutions to about 140 amino acid substitutions, about 10 amino acid substitutions to about 135 amino acid substitutions, about 10 amino acid substitutions to about 130 amino acid substitutions, about 10 amino acid substitutions to about 125 amino acid substitutions, about 10 amino acid substitutions to about 120 amino acid substitutions, about 10 amino acid substitutions to about 115 amino acid substitutions, about 10 amino acid substitutions to about 110 amino acid substitutions, about 10 amino acid substitutions to about 105 amino acid substitutions, about 10 amino acid substitutions to about 100 amino acid substitutions, about 10 amino acid substitutions to about 95 amino acid substitutions, about 10 amino acid substitutions to about 90 amino acid substitutions, about 10 amino acid substitutions to about 85 amino acid substitutions, about 10 amino acid substitutions to about 80 amino acid substitutions, about 10 amino acid substitutions to about 75 amino acid substitutions, about 10 amino acid substitutions to about 70 amino acid substitutions, about 10 amino acid substitutions to about 65 amino acid substitutions, about 10 amino acid substitutions to about 60 amino acid substitutions, about 10 amino acid substitutions to about 55 amino acid substitutions, about 10 amino acid substitutions to about 50 amino acid substitutions, about 10 amino acid substitutions to about 45 amino acid substitutions, about 10 amino acid substitutions to about 40 amino acid substitutions, about 10 amino acid substitutions to about 35 amino acid substitutions, about 10 amino acid substitutions to about 30 amino acid substitutions, about 10 amino acid substitutions to about 25 amino acid substitutions, about 10 amino acid substitutions to about 20 amino acid substitutions, about 10 amino acid substitutions to about 15 amino acid substitutions, between about 15 amino acid substitutions to about 160 amino acid substitutions, about 15 amino acid substitutions to about 155 amino acid substitutions, about 15 amino acid substitutions to about 150 amino acid substitutions, about 15 amino acid substitutions to about 145 amino acid substitutions, about 15 amino acid substitutions to about 140 amino acid substitutions, about 15 amino acid substitutions to about 135 amino acid substitutions, about 15 amino acid substitutions to about 130 amino acid substitutions, about 15 amino acid substitutions to about 125 amino acid substitutions, about 15 amino acid substitutions to about 120 amino acid substitutions, about 15 amino acid substitutions to about 115 amino acid substitutions, about 15 amino acid substitutions to about 110 amino acid substitutions, about 15 amino acid substitutions to about 105 amino acid substitutions, about 15 amino acid substitutions to about 100 amino acid substitutions, about 15 amino acid substitutions to about 95 amino acid substitutions, about 15 amino acid substitutions to about 90 amino acid substitutions, about 15 amino acid substitutions to about 85 amino acid substitutions, about 15 amino acid substitutions to about 80 amino acid substitutions, about 15 amino acid substitutions to about 75 amino acid substitutions, about 15 amino acid substitutions to about 70 amino acid substitutions, about 15 amino acid substitutions to about 65 amino acid substitutions, about 15 amino acid substitutions to about 60 amino acid substitutions, about 15 amino acid substitutions to about 55 amino acid substitutions, about 15 amino acid substitutions to about 50 amino acid substitutions, about 15 amino acid substitutions to about 45 amino acid substitutions, about 15 amino acid substitutions to about 40 amino acid substitutions, about 15 amino acid substitutions to about 35 amino acid substitutions, about 15 amino acid substitutions to about 30 amino acid substitutions, about 15 amino acid substitutions to about 25 amino acid substitutions, about 15 amino acid substitutions to about 20 amino acid substitutions, between about 20 amino acid substitutions to about 160 amino acid substitutions, about 20 amino acid substitutions to about 155 amino acid substitutions, about 20 amino acid substitutions to about 150 amino acid substitutions, about 20 amino acid substitutions to about 145 amino acid substitutions, about 20 amino acid substitutions to about 140 amino acid substitutions, about 20 amino acid substitutions to about 135 amino acid substitutions, about 20 amino acid substitutions to about 130 amino acid substitutions, about 20 amino acid substitutions to about 125 amino acid substitutions, about 20 amino acid substitutions to about 120 amino acid substitutions, about 20 amino acid substitutions to about 115 amino acid substitutions, about 20 amino acid substitutions to about 110 amino acid substitutions, about 20 amino acid substitutions to about 105 amino acid substitutions, about 20 amino acid substitutions to about 100 amino acid substitutions, about 20 amino acid substitutions to about 95 amino acid substitutions, about 20 amino acid substitutions to about 90 amino acid substitutions, about 20 amino acid substitutions to about 85 amino acid substitutions, about 20 amino acid substitutions to about 80 amino acid substitutions, about 20 amino acid substitutions to about 75 amino acid substitutions, about 20 amino acid substitutions to about 70 amino acid substitutions, about 20 amino acid substitutions to about 65 amino acid substitutions, about 20 amino acid substitutions to about 60 amino acid substitutions, about 20 amino acid substitutions to about 55 amino acid substitutions, about 20 amino acid substitutions to about 50 amino acid substitutions, about 20 amino acid substitutions to about 45 amino acid substitutions, about 20 amino acid substitutions to about 40 amino acid substitutions, about 20 amino acid substitutions to about 35 amino acid substitutions, about 20 amino acid substitutions to about 30 amino acid substitutions, about 20 amino acid substitutions to about 25 amino acid substitutions, between about 25 amino acid substitutions to about 160 amino acid substitutions, about 25 amino acid substitutions to about 155 amino acid substitutions, about 25 amino acid substitutions to about 150 amino acid substitutions, about 25 amino acid substitutions to about 145 amino acid substitutions, about 25 amino acid substitutions to about 140 amino acid substitutions, about 25 amino acid substitutions to about 135 amino acid substitutions, about 25 amino acid substitutions to about 130 amino acid substitutions, about 25 amino acid substitutions to about 125 amino acid substitutions, about 25 amino acid substitutions to about 120 amino acid substitutions, about 25 amino acid substitutions to about 115 amino acid substitutions, about 25 amino acid substitutions to about 110 amino acid substitutions, about 25 amino acid substitutions to about 105 amino acid substitutions, about 25 amino acid substitutions to about 100 amino acid substitutions, about 25 amino acid substitutions to about 95 amino acid substitutions, about 25 amino acid substitutions to about 90 amino acid substitutions, about 25 amino acid substitutions to about 85 amino acid substitutions, about 25 amino acid substitutions to about 80 amino acid substitutions, about 25 amino acid substitutions to about 75 amino acid substitutions, about 25 amino acid substitutions to about 70 amino acid substitutions, about 25 amino acid substitutions to about 65 amino acid substitutions, about 25 amino acid substitutions to about 60 amino acid substitutions, about 25 amino acid substitutions to about 55 amino acid substitutions, about 25 amino acid substitutions to about 50 amino acid substitutions, about 25 amino acid substitutions to about 45 amino acid substitutions, about 25 amino acid substitutions to about 40 amino acid substitutions, about 25 amino acid substitutions to about 35 amino acid substitutions, about 25 amino acid substitutions to about 30 amino acid substitutions, between about 30 amino acid substitutions to about 160 amino acid substitutions, about 30 amino acid substitutions to about 155 amino acid substitutions, about 30 amino acid substitutions to about 150 amino acid substitutions, about 30 amino acid substitutions to about 145 amino acid substitutions, about 30 amino acid substitutions to about 140 amino acid substitutions, about 30 amino acid substitutions to about 135 amino acid substitutions, about 30 amino acid substitutions to about 130 amino acid substitutions, about 30 amino acid substitutions to about 125 amino acid substitutions, about 30 amino acid substitutions to about 120 amino acid substitutions, about 30 amino acid substitutions to about 115 amino acid substitutions, about 30 amino acid substitutions to about 110 amino acid substitutions, about 30 amino acid substitutions to about 105 amino acid substitutions, about 30 amino acid substitutions to about 100 amino acid substitutions, about 30 amino acid substitutions to about 95 amino acid substitutions, about 30 amino acid substitutions to about 90 amino acid substitutions, about 30 amino acid substitutions to about 85 amino acid substitutions, about 30 amino acid substitutions to about 80 amino acid substitutions, about 30 amino acid substitutions to about 75 amino acid substitutions, about 30 amino acid substitutions to about 70 amino acid substitutions, about 30 amino acid substitutions to about 65 amino acid substitutions, about 30 amino acid substitutions to about 60 amino acid substitutions, about 30 amino acid substitutions to about 55 amino acid substitutions, about 30 amino acid substitutions to about 50 amino acid substitutions, about 30 amino acid substitutions to about 45 amino acid substitutions, about 30 amino acid substitutions to about 40 amino acid substitutions, about 30 amino acid substitutions to about 35 amino acid substitutions, between about 35 amino acid substitutions to about 160 amino acid substitutions, about 35 amino acid substitutions to about 155 amino acid substitutions, about 35 amino acid substitutions to about 150 amino acid substitutions, about 35 amino acid substitutions to about 145 amino acid substitutions, about 35 amino acid substitutions to about 140 amino acid substitutions, about 35 amino acid substitutions to about 135 amino acid substitutions, about 35 amino acid substitutions to about 130 amino acid substitutions, about 35 amino acid substitutions to about 125 amino acid substitutions, about 35 amino acid substitutions to about 120 amino acid substitutions, about 35 amino acid substitutions to about 115 amino acid substitutions, about 35 amino acid substitutions to about 110 amino acid substitutions, about 35 amino acid substitutions to about 105 amino acid substitutions, about 35 amino acid substitutions to about 100 amino acid substitutions, about 35 amino acid substitutions to about 95 amino acid substitutions, about 35 amino acid substitutions to about 90 amino acid substitutions, about 35 amino acid substitutions to about 85 amino acid substitutions, about 35 amino acid substitutions to about 80 amino acid substitutions, about 35 amino acid substitutions to about 75 amino acid substitutions, about 35 amino acid substitutions to about 70 amino acid substitutions, about 35 amino acid substitutions to about 65 amino acid substitutions, about 35 amino acid substitutions to about 60 amino acid substitutions, about 35 amino acid substitutions to about 55 amino acid substitutions, about 35 amino acid substitutions to about 50 amino acid substitutions, about 35 amino acid substitutions to about 45 amino acid substitutions, about 35 amino acid substitutions to about 40 amino acid substitutions, between about 40 amino acid substitutions to about 160 amino acid substitutions, about 40 amino acid substitutions to about 155 amino acid substitutions, about 40 amino acid substitutions to about 150 amino acid substitutions, about 40 amino acid substitutions to about 145 amino acid substitutions, about 40 amino acid substitutions to about 140 amino acid substitutions, about 40 amino acid substitutions to about 135 amino acid substitutions, about 40 amino acid substitutions to about 130 amino acid substitutions, about 40 amino acid substitutions to about 125 amino acid substitutions, about 40 amino acid substitutions to about 120 amino acid substitutions, about 40 amino acid substitutions to about 115 amino acid substitutions, about 40 amino acid substitutions to about 110 amino acid substitutions, about 40 amino acid substitutions to about 105 amino acid substitutions, about 40 amino acid substitutions to about 100 amino acid substitutions, about 40 amino acid substitutions to about 95 amino acid substitutions, about 40 amino acid substitutions to about 90 amino acid substitutions, about 40 amino acid substitutions to about 85 amino acid substitutions, about 40 amino acid substitutions to about 80 amino acid substitutions, about 40 amino acid substitutions to about 75 amino acid substitutions, about 40 amino acid substitutions to about 70 amino acid substitutions, about 40 amino acid substitutions to about 65 amino acid substitutions, about 40 amino acid substitutions to about 60 amino acid substitutions, about 40 amino acid substitutions to about 55 amino acid substitutions, about 40 amino acid substitutions to about 50 amino acid substitutions, about 40 amino acid substitutions to about 45 amino acid substitutions, between about 45 amino acid substitutions to about 160 amino acid substitutions, about 45 amino acid substitutions to about 155 amino acid substitutions, about 45 amino acid substitutions to about 150 amino acid substitutions, about 45 amino acid substitutions to about 145 amino acid substitutions, about 45 amino acid substitutions to about 140 amino acid substitutions, about 45 amino acid substitutions to about 135 amino acid substitutions, about 45 amino acid substitutions to about 130 amino acid substitutions, about 45 amino acid substitutions to about 125 amino acid substitutions, about 45 amino acid substitutions to about 120 amino acid substitutions, about 45 amino acid substitutions to about 115 amino acid substitutions, about 45 amino acid substitutions to about 110 amino acid substitutions, about 45 amino acid substitutions to about 105 amino acid substitutions, about 45 amino acid substitutions to about 100 amino acid substitutions, about 45 amino acid substitutions to about 95 amino acid substitutions, about 45 amino acid substitutions to about 90 amino acid substitutions, about 45 amino acid substitutions to about 85 amino acid substitutions, about 45 amino acid substitutions to about 80 amino acid substitutions, about 45 amino acid substitutions to about 75 amino acid substitutions, about 45 amino acid substitutions to about 70 amino acid substitutions, about 45 amino acid substitutions to about 65 amino acid substitutions, about 45 amino acid substitutions to about 60 amino acid substitutions, about 45 amino acid substitutions to about 55 amino acid substitutions, about 45 amino acid substitutions to about 50 amino acid substitutions, between about 50 amino acid substitutions to about 160 amino acid substitutions, about 50 amino acid substitutions to about 155 amino acid substitutions, about 50 amino acid substitutions to about 150 amino acid substitutions, about 50 amino acid substitutions to about 145 amino acid substitutions, about 50 amino acid substitutions to about 140 amino acid substitutions, about 50 amino acid substitutions to about 135 amino acid substitutions, about 50 amino acid substitutions to about 130 amino acid substitutions, about 50 amino acid substitutions to about 125 amino acid substitutions, about 50 amino acid substitutions to about 120 amino acid substitutions, about 50 amino acid substitutions to about 115 amino acid substitutions, about 50 amino acid substitutions to about 110 amino acid substitutions, about 50 amino acid substitutions to about 105 amino acid substitutions, about 50 amino acid substitutions to about 100 amino acid substitutions, about 50 amino acid substitutions to about 95 amino acid substitutions, about 50 amino acid substitutions to about 90 amino acid substitutions, about 50 amino acid substitutions to about 85 amino acid substitutions, about 50 amino acid substitutions to about 80 amino acid substitutions, about 50 amino acid substitutions to about 75 amino acid substitutions, about 50 amino acid substitutions to about 70 amino acid substitutions, about 50 amino acid substitutions to about 65 amino acid substitutions, about 50 amino acid substitutions to about 60 amino acid substitutions, about 50 amino acid substitutions to about 55 amino acid substitutions, between about 60 amino acid substitutions to about 160 amino acid substitutions, about 60 amino acid substitutions to about 155 amino acid substitutions, about 60 amino acid substitutions to about 150 amino acid substitutions, about 60 amino acid substitutions to about 145 amino acid substitutions, about 60 amino acid substitutions to about 140 amino acid substitutions, about 60 amino acid substitutions to about 135 amino acid substitutions, about 60 amino acid substitutions to about 130 amino acid substitutions, about 60 amino acid substitutions to about 125 amino acid substitutions, about 60 amino acid substitutions to about 120 amino acid substitutions, about 60 amino acid substitutions to about 115 amino acid substitutions, about 60 amino acid substitutions to about 110 amino acid substitutions, about 60 amino acid substitutions to about 105 amino acid substitutions, about 60 amino acid substitutions to about 100 amino acid substitutions, about 60 amino acid substitutions to about 95 amino acid substitutions, about 60 amino acid substitutions to about 90 amino acid substitutions, about 60 amino acid substitutions to about 85 amino acid substitutions, about 60 amino acid substitutions to about 80 amino acid substitutions, about 60 amino acid substitutions to about 75 amino acid substitutions, about 60 amino acid substitutions to about 70 amino acid substitutions, about 60 amino acid substitutions to about 65 amino acid substitutions, between about 70 amino acid substitutions to about 160 amino acid substitutions, about 70 amino acid substitutions to about 155 amino acid substitutions, about 70 amino acid substitutions to about 150 amino acid substitutions, about 70 amino acid substitutions to about 145 amino acid substitutions, about 70 amino acid substitutions to about 140 amino acid substitutions, about 70 amino acid substitutions to about 135 amino acid substitutions, about 70 amino acid substitutions to about 130 amino acid substitutions, about 70 amino acid substitutions to about 125 amino acid substitutions, about 70 amino acid substitutions to about 120 amino acid substitutions, about 70 amino acid substitutions to about 115 amino acid substitutions, about 70 amino acid substitutions to about 110 amino acid substitutions, about 70 amino acid substitutions to about 105 amino acid substitutions, about 70 amino acid substitutions to about 100 amino acid substitutions, about 70 amino acid substitutions to about 95 amino acid substitutions, about 70 amino acid substitutions to about 90 amino acid substitutions, about 70 amino acid substitutions to about 85 amino acid substitutions, about 70 amino acid substitutions to about 80 amino acid substitutions, about 70 amino acid substitutions to about 75 amino acid substitutions, between about 80 amino acid substitutions to about 160 amino acid substitutions, about 80 amino acid substitutions to about 155 amino acid substitutions, about 80 amino acid substitutions to about 150 amino acid substitutions, about 80 amino acid substitutions to about 145 amino acid substitutions, about 80 amino acid substitutions to about 140 amino acid substitutions, about 80 amino acid substitutions to about 135 amino acid substitutions, about 80 amino acid substitutions to about 130 amino acid substitutions, about 80 amino acid substitutions to about 125 amino acid substitutions, about 80 amino acid substitutions to about 120 amino acid substitutions, about 80 amino acid substitutions to about 115 amino acid substitutions, about 80 amino acid substitutions to about 110 amino acid substitutions, about 80 amino acid substitutions to about 105 amino acid substitutions, about 80 amino acid substitutions to about 100 amino acid substitutions, about 80 amino acid substitutions to about 95 amino acid substitutions, about 80 amino acid substitutions to about 90 amino acid substitutions, about 80 amino acid substitutions to about 85 amino acid substitutions, between about 90 amino acid substitutions to about 160 amino acid substitutions, about 90 amino acid substitutions to about 155 amino acid substitutions, about 90 amino acid substitutions to about 150 amino acid substitutions, about 90 amino acid substitutions to about 145 amino acid substitutions, about 90 amino acid substitutions to about 140 amino acid substitutions, about 90 amino acid substitutions to about 135 amino acid substitutions, about 90 amino acid substitutions to about 130 amino acid substitutions, about 90 amino acid substitutions to about 125 amino acid substitutions, about 90 amino acid substitutions to about 120 amino acid substitutions, about 90 amino acid substitutions to about 115 amino acid substitutions, about 90 amino acid substitutions to about 110 amino acid substitutions, about 90 amino acid substitutions to about 105 amino acid substitutions, about 90 amino acid substitutions to about 100 amino acid substitutions, about 90 amino acid substitutions to about 95 amino acid substitutions, between about 100 amino acid substitutions to about 160 amino acid substitutions, about 100 amino acid substitutions to about 155 amino acid substitutions, about 100 amino acid substitutions to about 150 amino acid substitutions, about 100 amino acid substitutions to about 145 amino acid substitutions, about 100 amino acid substitutions to about 140 amino acid substitutions, about 100 amino acid substitutions to about 135 amino acid substitutions, about 100 amino acid substitutions to about 130 amino acid substitutions, about 100 amino acid substitutions to about 125 amino acid substitutions, about 100 amino acid substitutions to about 120 amino acid substitutions, about 100 amino acid substitutions to about 115 amino acid substitutions, about 100 amino acid substitutions to about 110 amino acid substitutions, about 100 amino acid substitutions to about 105 amino acid substitutions, between about 110 amino acid substitutions to about 160 amino acid substitutions, about 110 amino acid substitutions to about 155 amino acid substitutions, about 110 amino acid substitutions to about 150 amino acid substitutions, about 110 amino acid substitutions to about 145 amino acid substitutions, about 110 amino acid substitutions to about 140 amino acid substitutions, about 110 amino acid substitutions to about 135 amino acid substitutions, about 110 amino acid substitutions to about 130 amino acid substitutions, about 110 amino acid substitutions to about 125 amino acid substitutions, about 110 amino acid substitutions to about 120 amino acid substitutions, about 110 amino acid substitutions to about 115 amino acid substitutions, between about 120 amino acid substitutions to about 160 amino acid substitutions, about 120 amino acid substitutions to about 155 amino acid substitutions, about 120 amino acid substitutions to about 150 amino acid substitutions, about 120 amino acid substitutions to about 145 amino acid substitutions, about 120 amino acid substitutions to about 140 amino acid substitutions, about 120 amino acid substitutions to about 135 amino acid substitutions, about 120 amino acid substitutions to about 130 amino acid substitutions, about 120 amino acid substitutions to about 125 amino acid substitutions, between about 130 amino acid substitutions to about 160 amino acid substitutions, about 130 amino acid substitutions to about 155 amino acid substitutions, about 130 amino acid substitutions to about 150 amino acid substitutions, about 130 amino acid substitutions to about 145 amino acid substitutions, about 130 amino acid substitutions to about 140 amino acid substitutions, about 130 amino acid substitutions to about 135 amino acid substitutions, between about 140 amino acid substitutions to about 160 amino acid substitutions, about 140 amino acid substitutions to about 155 amino acid substitutions, about 140 amino acid substitutions to about 150 amino acid substitutions, about 140 amino acid substitutions to about 145 amino acid substitutions, between about 150 amino acid substitutions to about 160 amino acid substitutions, or about 150 amino acid substitutions to about 155 amino acid substitutions. One skilled in the art would appreciate that amino acids that are conserved between wildtype supporting cell target proteins from different species or wildtype hair cell target proteins from different species can be mutated without losing activity, while those amino acids that are not conserved between wildtype supporting cell target proteins from different species or wildtype hair cell target proteins from different species should not be mutated as they are more likely (than amino acids that are not conserved between different species) to be involved in activity.

An active target protein (e.g., a supporting cell target protein or a hair cell target protein) can include, e.g., a sequence of a wildtype, full-length target protein (e.g., a supporting cell target protein (e.g., a wildtype, human, full-length supporting cell target protein) or a hair cell target protein (e.g., a wildtype, human, full-length hair cell target protein) that has 1 amino acid to about 50 amino acids, 1 amino acid to about 45 amino acids, 1 amino acid to about 40 amino acids, 1 amino acid to about 35 amino acids, 1 amino acid to about 30 amino acids, 1 amino acid to about 25 amino acids, 1 amino acid to about 20 amino acids, 1 amino acid to about 15 amino acids, 1 amino acid to about 10 amino acids, 1 amino acid to about 9 amino acids, 1 amino acid to about 8 amino acids, 1 amino acid to about 7 amino acids, 1 amino acid to about 6 amino acids, 1 amino acid to about 5 amino acids, 1 amino acid to about 4 amino acids, 1 amino acid to about 3 amino acids, about 2 amino acids to about 50 amino acids, about 2 amino acids to about 45 amino acids, about 2 amino acids to about 40 amino acids, about 2 amino acids to about 35 amino acids, about 2 amino acids to about 30 amino acids, about 2 amino acids to about 25 amino acids, about 2 amino acids to about 20 amino acids, about 2 amino acids to about 15 amino acids, about 2 amino acids to about 10 amino acids, about 2 amino acids to about 9 amino acids, about 2 amino acids to about 8 amino acids, about 2 amino acids to about 7 amino acids, about 2 amino acids to about 6 amino acids, about 2 amino acids to about 5 amino acids, about 2 amino acids to about 4 amino acids, about 3 amino acids to about 50 amino acids, about 3 amino acids to about 45 amino acids, about 3 amino acids to about 40 amino acids, about 3 amino acids to about 35 amino acids, about 3 amino acids to about 30 amino acids, about 3 amino acids to about 25 amino acids, about 3 amino acids to about 20 amino acids, about 3 amino acids to about 15 amino acids, about 3 amino acids to about 10 amino acids, about 3 amino acids to about 9 amino acids, about 3 amino acids to about 8 amino acids, about 3 amino acids to about 7 amino acids, about 3 amino acids to about 6 amino acids, about 3 amino acids to about 5 amino acids, about 4 amino acids to about 50 amino acids, about 4 amino acids to about 45 amino acids, about 4 amino acids to about 40 amino acids, about 4 amino acids to about 35 amino acids, about 4 amino acids to about 30 amino acids, about 4 amino acids to about 25 amino acids, about 4 amino acids to about 20 amino acids, about 4 amino acids to about 15 amino acids, about 4 amino acids to about 10 amino acids, about 4 amino acids to about 9 amino acids, about 4 amino acids to about 8 amino acids, about 4 amino acids to about 7 amino acids, about 4 amino acids to about 6 amino acids, about 5 amino acids to about 50 amino acids, about 5 amino acids to about 45 amino acids, about 5 amino acids to about 40 amino acids, about 5 amino acids to about 35 amino acids, about 5 amino acids to about 30 amino acids, about 5 amino acids to about 25 amino acids, about 5 amino acids to about 20 amino acids, about 5 amino acids to about 15 amino acids, about 5 amino acids to about 10 amino acids, about 5 amino acids to about 9 amino acids, about 5 amino acids to about 8 amino acids, about 5 amino acids to about 7 amino acids, about 6 amino acids to about 50 amino acids, about 6 amino acids to about 45 amino acids, about 6 amino acids to about 40 amino acids, about 6 amino acids to about 35 amino acids, about 6 amino acids to about 30 amino acids, about 6 amino acids to about 25 amino acids, about 6 amino acids to about 20 amino acids, about 6 amino acids to about 15 amino acids, about 6 amino acids to about 10 amino acids, about 6 amino acids to about 9 amino acids, about 6 amino acids to about 8 amino acids, about 7 amino acids to about 50 amino acids, about 7 amino acids to about 45 amino acids, about 7 amino acids to about 40 amino acids, about 7 amino acids to about 35 amino acids, about 7 amino acids to about 30 amino acids, about 7 amino acids to about 25 amino acids, about 7 amino acids to about 20 amino acids, about 7 amino acids to about 15 amino acids, about 7 amino acids to about 10 amino acids, about 7 amino acids to about 9 amino acids, about 8 amino acids to about 50 amino acids, about 8 amino acids to about 45 amino acids, about 8 amino acids to about 40 amino acids, about 8 amino acids to about 35 amino acids, about 8 amino acids to about 30 amino acids, about 8 amino acids to about 25 amino acids, about 8 amino acids to about 20 amino acids, about 8 amino acids to about 15 amino acids, about 8 amino acids to about 10 amino acids, about 10 amino acids to about 50 amino acids, about 10 amino acids to about 45 amino acids, about 10 amino acids to about 40 amino acids, about 10 amino acids to about 35 amino acids, about 10 amino acids to about 30 amino acids, about 10 amino acids to about 25 amino acids, about 10 amino acids to about 20 amino acids, about 10 amino acids to about 15 amino acids, about 15 amino acids to about 50 amino acids, about 15 amino acids to about 45 amino acids, about 15 amino acids to about 40 amino acids, about 15 amino acids to about 35 amino acids, about 15 amino acids to about 30 amino acids, about 15 amino acids to about 25 amino acids, about 15 amino acids to about 20 amino acids, about 20 amino acids to about 50 amino acids, about 20 amino acids to about 45 amino acids, about 20 amino acids to about 40 amino acids, about 20 amino acids to about 35 amino acids, about 20 amino acids to about 30 amino acids, about 20 amino acids to about 25 amino acids, about 25 amino acids to about 50 amino acids, about 25 amino acids to about 45 amino acids, about 25 amino acids to about 40 amino acids, about 25 amino acids to about 35 amino acids, about 25 amino acids to about 30 amino acids, about 30 amino acids to about 50 amino acids, about 30 amino acids to about 45 amino acids, about 30 amino acids to about 40 amino acids, about 30 amino acids to about 35 amino acids, about 35 amino acids to about 50 amino acids, about 35 amino acids to about 45 amino acids, about 35 amino acids to about 40 amino acids, about 40 amino acids to about 50 amino acids, about 40 amino acids to about 45 amino acids, about 45 amino acids to about 50 amino acids, deleted. In some embodiments where two or more amino acids are deleted from the sequence of a wildtype, full-length hair cell target protein, the two or more deleted amino acids can be contiguous in the sequence of the wildtype, full-length protein. In other examples where two or more amino acids are deleted from the sequence of a wildtype, full-length hair cell target protein, the two or more deleted amino acids are not contiguous in the sequence of the wildtype, full-length protein. One skilled in the art would appreciate that amino acids that are not conserved between wildtype, full-length hair cell target proteins from different species can be deleted without losing activity, while those amino acids that are conserved between wildtype, full-length hair cell target proteins from different species should not be deleted as they are more likely (than amino acids that are not conserved between different species) to be involved in activity.

In some embodiments where two or more amino acids are deleted from the sequence of a wildtype, full-length supporting cell target protein, the two or more deleted amino acids can be contiguous in the sequence of the wildtype, full-length protein. In other examples where two or more amino acids are deleted from the sequence of a wildtype, full-length supporting cell target protein, the two or more deleted amino acids are not contiguous in the sequence of the wildtype, full-length protein. One skilled in the art would appreciate that amino acids that are not conserved between wildtype, full-length supporting cell target proteins from different species can be deleted without losing activity, while those amino acids that are conserved between wildtype, full-length supporting cell target proteins from different species should not be deleted as they are more likely (than amino acids that are not conserved between different species) to be involved in activity.

In some examples, an active target protein (e.g., a supporting cell target protein or a hair cell target protein) can, e.g., include a sequence of a wildtype, full-length target protein (e.g., a wildtype, full-length supporting cell target protein or a wildtype, full-length hair cell target protein) that has between 1 amino acid to about 100 amino acids, 1 amino acid to about 95 amino acids, 1 amino acid to about 90 amino acids, 1 amino acid to about 85 amino acids, 1 amino acid to about 80 amino acids, 1 amino acid to about 75 amino acids, 1 amino acid to about 70 amino acids, 1 amino acid to about 65 amino acids, 1 amino acid to about 60 amino acids, 1 amino acid to about 55 amino acids, 1 amino acid to about 50 amino acids, 1 amino acid to about 45 amino acids, 1 amino acid to about 40 amino acids, 1 amino acid to about 35 amino acids, 1 amino acid to about 30 amino acids, 1 amino acid to about 25 amino acids, 1 amino acid to about 20 amino acids, 1 amino acid to about 15 amino acids, 1 amino acid to about 10 amino acids, 1 amino acid to about 9 amino acids, 1 amino acid to about 8 amino acids, 1 amino acid to about 7 amino acids, 1 amino acid to about 6 amino acids, 1 amino acid to about 5 amino acids, 1 amino acid to about 4 amino acids, 1 amino acid to about 3 amino acids, about 2 amino acids to about 100 amino acids, about 2 amino acid to about 95 amino acids, about 2 amino acids to about 90 amino acids, about 2 amino acids to about 85 amino acids, about 2 amino acids to about 80 amino acids, about 2 amino acids to about 75 amino acids, about 2 amino acids to about 70 amino acids, about 2 amino acids to about 65 amino acids, about 2 amino acids to about 60 amino acids, about 2 amino acids to about 55 amino acids, about 2 amino acids to about 50 amino acids, about 2 amino acids to about 45 amino acids, about 2 amino acids to about 40 amino acids, about 2 amino acids to about 35 amino acids, about 2 amino acids to about 30 amino acids, about 2 amino acids to about 25 amino acids, about 2 amino acids to about 20 amino acids, about 2 amino acids to about 15 amino acids, about 2 amino acids to about 10 amino acids, about 2 amino acids to about 9 amino acids, about 2 amino acids to about 8 amino acids, about 2 amino acids to about 7 amino acids, about 2 amino acids to about 6 amino acids, about 2 amino acids to about 5 amino acids, about 2 amino acids to about 4 amino acids, about 3 amino acids to about 100 amino acids, about 3 amino acid to about 95 amino acids, about 3 amino acids to about 90 amino acids, about 3 amino acids to about 85 amino acids, about 3 amino acids to about 80 amino acids, about 3 amino acids to about 75 amino acids, about 3 amino acids to about 70 amino acids, about 3 amino acids to about 65 amino acids, about 3 amino acids to about 60 amino acids, about 3 amino acids to about 55 amino acids, about 3 amino acids to about 50 amino acids, about 3 amino acids to about 45 amino acids, about 3 amino acids to about 40 amino acids, about 3 amino acids to about 35 amino acids, about 3 amino acids to about 30 amino acids, about 3 amino acids to about 25 amino acids, about 3 amino acids to about 20 amino acids, about 3 amino acids to about 15 amino acids, about 3 amino acids to about 10 amino acids, about 3 amino acids to about 9 amino acids, about 3 amino acids to about 8 amino acids, about 3 amino acids to about 7 amino acids, about 3 amino acids to about 6 amino acids, about 3 amino acids to about 5 amino acids, about 4 amino acids to about 100 amino acids, about 4 amino acid to about 95 amino acids, about 4 amino acids to about 90 amino acids, about 4 amino acids to about 85 amino acids, about 4 amino acids to about 80 amino acids, about 4 amino acids to about 75 amino acids, about 4 amino acids to about 70 amino acids, about 4 amino acids to about 65 amino acids, about 4 amino acids to about 60 amino acids, about 4 amino acids to about 55 amino acids, about 4 amino acids to about 50 amino acids, about 4 amino acids to about 45 amino acids, about 4 amino acids to about 40 amino acids, about 4 amino acids to about 35 amino acids, about 4 amino acids to about 30 amino acids, about 4 amino acids to about 25 amino acids, about 4 amino acids to about 20 amino acids, about 4 amino acids to about 15 amino acids, about 4 amino acids to about 10 amino acids, about 4 amino acids to about 9 amino acids, about 4 amino acids to about 8 amino acids, about 4 amino acids to about 7 amino acids, about 4 amino acids to about 6 amino acids, about 5 amino acids to about 100 amino acids, about 5 amino acid to about 95 amino acids, about 5 amino acids to about 90 amino acids, about 5 amino acids to about 85 amino acids, about 5 amino acids to about 80 amino acids, about 5 amino acids to about 75 amino acids, about 5 amino acids to about 70 amino acids, about 5 amino acids to about 65 amino acids, about 5 amino acids to about 60 amino acids, about 5 amino acids to about 55 amino acids, about 5 amino acids to about 50 amino acids, about 5 amino acids to about 45 amino acids, about 5 amino acids to about 40 amino acids, about 5 amino acids to about 35 amino acids, about 5 amino acids to about 30 amino acids, about 5 amino acids to about 25 amino acids, about 5 amino acids to about 20 amino acids, about 5 amino acids to about 15 amino acids, about 5 amino acids to about 10 amino acids, about 5 amino acids to about 9 amino acids, about 5 amino acids to about 8 amino acids, about 5 amino acids to about 7 amino acids, about 6 amino acids to about 100 amino acids, about 6 amino acid to about 95 amino acids, about 6 amino acids to about 90 amino acids, about 6 amino acids to about 85 amino acids, about 6 amino acids to about 80 amino acids, about 6 amino acids to about 75 amino acids, about 6 amino acids to about 70 amino acids, about 6 amino acids to about 65 amino acids, about 6 amino acids to about 60 amino acids, about 6 amino acids to about 55 amino acids, about 6 amino acids to about 50 amino acids, about 6 amino acids to about 45 amino acids, about 6 amino acids to about 40 amino acids, about 6 amino acids to about 35 amino acids, about 6 amino acids to about 30 amino acids, about 6 amino acids to about 25 amino acids, about 6 amino acids to about 20 amino acids, about 6 amino acids to about 15 amino acids, about 6 amino acids to about 10 amino acids, about 6 amino acids to about 9 amino acids, about 6 amino acids to about 8 amino acids, about 7 amino acids to about 100 amino acids, about 7 amino acid to about 95 amino acids, about 7 amino acids to about 90 amino acids, about 7 amino acids to about 85 amino acids, about 7 amino acids to about 80 amino acids, about 7 amino acids to about 75 amino acids, about 7 amino acids to about 70 amino acids, about 7 amino acids to about 65 amino acids, about 7 amino acids to about 60 amino acids, about 7 amino acids to about 55 amino acids, about 7 amino acids to about 50 amino acids, about 7 amino acids to about 45 amino acids, about 7 amino acids to about 40 amino acids, about 7 amino acids to about 35 amino acids, about 7 amino acids to about 30 amino acids, about 7 amino acids to about 25 amino acids, about 7 amino acids to about 20 amino acids, about 7 amino acids to about 15 amino acids, about 7 amino acids to about 10 amino acids, about 7 amino acids to about 9 amino acids, about 8 amino acids to about 100 amino acids, about 8 amino acid to about 95 amino acids, about 8 amino acids to about 90 amino acids, about 8 amino acids to about 85 amino acids, about 8 amino acids to about 80 amino acids, about 8 amino acids to about 75 amino acids, about 8 amino acids to about 70 amino acids, about 8 amino acids to about 65 amino acids, about 8 amino acids to about 60 amino acids, about 8 amino acids to about 55 amino acids, about 8 amino acids to about 50 amino acids, about 8 amino acids to about 45 amino acids, about 8 amino acids to about 40 amino acids, about 8 amino acids to about 35 amino acids, about 8 amino acids to about 30 amino acids, about 8 amino acids to about 25 amino acids, about 8 amino acids to about 20 amino acids, about 8 amino acids to about 15 amino acids, about 8 amino acids to about 10 amino acids, about 10 amino acids to about 100 amino acids, about 10 amino acid to about 95 amino acids, about 10 amino acids to about 90 amino acids, about 10 amino acids to about 85 amino acids, about 10 amino acids to about 80 amino acids, about 10 amino acids to about 75 amino acids, about 10 amino acids to about 70 amino acids, about 10 amino acids to about 65 amino acids, about 10 amino acids to about 60 amino acids, about 10 amino acids to about 55 amino acids, about 10 amino acids to about 50 amino acids, about 10 amino acids to about 45 amino acids, about 10 amino acids to about 40 amino acids, about 10 amino acids to about 35 amino acids, about 10 amino acids to about 30 amino acids, about 10 amino acids to about 25 amino acids, about 10 amino acids to about 20 amino acids, about 10 amino acids to about 15 amino acids, about 20 amino acids to about 100 amino acids, about 20 amino acid to about 95 amino acids, about 20 amino acids to about 90 amino acids, about 20 amino acids to about 85 amino acids, about 20 amino acids to about 80 amino acids, about 20 amino acids to about 75 amino acids, about 20 amino acids to about 70 amino acids, about 20 amino acids to about 65 amino acids, about 20 amino acids to about 60 amino acids, about 20 amino acids to about 55 amino acids, about 20 amino acids to about 50 amino acids, about 20 amino acids to about 45 amino acids, about 20 amino acids to about 40 amino acids, about 20 amino acids to about 35 amino acids, about 20 amino acids to about 30 amino acids, about 20 amino acids to about 25 amino acids, about 30 amino acids to about 100 amino acids, about 30 amino acid to about 95 amino acids, about 30 amino acids to about 90 amino acids, about 30 amino acids to about 85 amino acids, about 30 amino acids to about 80 amino acids, about 30 amino acids to about 75 amino acids, about 30 amino acids to about 70 amino acids, about 30 amino acids to about 65 amino acids, about 30 amino acids to about 60 amino acids, about 30 amino acids to about 55 amino acids, about 30 amino acids to about 50 amino acids, about 30 amino acids to about 45 amino acids, about 30 amino acids to about 40 amino acids, about 30 amino acids to about 35 amino acids, about 40 amino acids to about 100 amino acids, about 40 amino acid to about 95 amino acids, about 40 amino acids to about 90 amino acids, about 40 amino acids to about 85 amino acids, about 40 amino acids to about 80 amino acids, about 40 amino acids to about 75 amino acids, about 40 amino acids to about 70 amino acids, about 40 amino acids to about 65 amino acids, about 40 amino acids to about 60 amino acids, about 40 amino acids to about 55 amino acids, about 40 amino acids to about 50 amino acids, about 40 amino acids to about 45 amino acids, about 50 amino acids to about 100 amino acids, about 50 amino acid to about 95 amino acids, about 50 amino acids to about 90 amino acids, about 50 amino acids to about 85 amino acids, about 50 amino acids to about 80 amino acids, about 50 amino acids to about 75 amino acids, about 50 amino acids to about 70 amino acids, about 50 amino acids to about 65 amino acids, about 50 amino acids to about 60 amino acids, about 50 amino acids to about 55 amino acids, about 60 amino acids to about 100 amino acids, about 60 amino acid to about 95 amino acids, about 60 amino acids to about 90 amino acids, about 60 amino acids to about 85 amino acids, about 60 amino acids to about 80 amino acids, about 60 amino acids to about 75 amino acids, about 60 amino acids to about 70 amino acids, about 60 amino acids to about 65 amino acids, about 70 amino acids to about 100 amino acids, about 70 amino acid to about 95 amino acids, about 70 amino acids to about 90 amino acids, about 70 amino acids to about 85 amino acids, about 70 amino acids to about 80 amino acids, about 70 amino acids to about 75 amino acids, about 80 amino acids to about 100 amino acids, about 80 amino acid to about 95 amino acids, about 80 amino acids to about 90 amino acids, about 80 amino acids to about 85 amino acids, about 90 amino acids to about 100 amino acids, about 90 amino acids to about 95 amino acids, or about 95 amino acids to about 100 amino acids, removed from its N-terminus and/or 1 amino acid to 100 amino acids (or any of the subranges of this range described herein) removed from its C-terminus.

In some embodiments, an active target protein (e.g., a supporting cell target protein or a hair cell target protein) can, e.g., include the sequence of a wildtype, full-length target protein (e.g., a wildtype, full-length supporting cell target protein or a wildtype, full-length hair cell target protein) where 1 amino acid to 50 amino acids, 1 amino acid to 45 amino acids, 1 amino acid to 40 amino acids, 1 amino acid to 35 amino acids, 1 amino acid to 30 amino acids, 1 amino acid to 25 amino acids, 1 amino acid to 20 amino acids, 1 amino acid to 15 amino acids, 1 amino acid to 10 amino acids, 1 amino acid to 9 amino acids, 1 amino acid to 8 amino acids, 1 amino acid to 7 amino acids, 1 amino acid to 6 amino acids, 1 amino acid to 5 amino acids, 1 amino acid to 4 amino acids, 1 amino acid to 3 amino acids, about 2 amino acids to 50 amino acids, about 2 amino acids to 45 amino acids, about 2 amino acids to 40 amino acids, about 2 amino acids to 35 amino acids, about 2 amino acids to 30 amino acids, about 2 amino acids to 25 amino acids, about 2 amino acids to 20 amino acids, about 2 amino acids to 15 amino acids, about 2 amino acids to 10 amino acids, about 2 amino acids to 9 amino acids, about 2 amino acids to 8 amino acids, about 2 amino acids to 7 amino acids, about 2 amino acids to 6 amino acids, about 2 amino acids to 5 amino acids, about 2 amino acids to 4 amino acids, about 3 amino acids to 50 amino acids, about 3 amino acids to 45 amino acids, about 3 amino acids to 40 amino acids, about 3 amino acids to 35 amino acids, about 3 amino acids to 30 amino acids, about 3 amino acids to 25 amino acids, about 3 amino acids to 20 amino acids, about 3 amino acids to 15 amino acids, about 3 amino acids to 10 amino acids, about 3 amino acids to 9 amino acids, about 3 amino acids to 8 amino acids, about 3 amino acids to 7 amino acids, about 3 amino acids to 6 amino acids, about 3 amino acids to 5 amino acids, about 4 amino acids to 50 amino acids, about 4 amino acids to 45 amino acids, about 4 amino acids to 40 amino acids, about 4 amino acids to 35 amino acids, about 4 amino acids to 30 amino acids, about 4 amino acids to 25 amino acids, about 4 amino acids to 20 amino acids, about 4 amino acids to 15 amino acids, about 4 amino acids to 10 amino acids, about 4 amino acids to 9 amino acids, about 4 amino acids to 8 amino acids, about 4 amino acids to 7 amino acids, about 4 amino acids to 6 amino acids, about 5 amino acids to 50 amino acids, about 5 amino acids to 45 amino acids, about 5 amino acids to 40 amino acids, about 5 amino acids to 35 amino acids, about 5 amino acids to 30 amino acids, about 5 amino acids to 25 amino acids, about 5 amino acids to 20 amino acids, about 5 amino acids to 15 amino acids, about 5 amino acids to 10 amino acids, about 5 amino acids to 9 amino acids, about 5 amino acids to 8 amino acids, about 5 amino acids to 7 amino acids, about 6 amino acids to 50 amino acids, about 6 amino acids to 45 amino acids, about 6 amino acids to 40 amino acids, about 6 amino acids to 35 amino acids, about 6 amino acids to 30 amino acids, about 6 amino acids to 25 amino acids, about 6 amino acids to 20 amino acids, about 6 amino acids to 15 amino acids, about 6 amino acids to 10 amino acids, about 6 amino acids to 9 amino acids, about 6 amino acids to 8 amino acids, about 7 amino acids to 50 amino acids, about 7 amino acids to 45 amino acids, about 7 amino acids to 40 amino acids, about 7 amino acids to 35 amino acids, about 7 amino acids to 30 amino acids, about 7 amino acids to 25 amino acids, about 7 amino acids to 20 amino acids, about 7 amino acids to 15 amino acids, about 7 amino acids to 10 amino acids, about 7 amino acids to 9 amino acids, about 8 amino acids to 50 amino acids, about 8 amino acids to 45 amino acids, about 8 amino acids to 40 amino acids, about 8 amino acids to 35 amino acids, about 8 amino acids to 30 amino acids, about 8 amino acids to 25 amino acids, about 8 amino acids to 20 amino acids, about 8 amino acids to 15 amino acids, about 8 amino acids to 10 amino acids, about 10 amino acids to 50 amino acids, about 10 amino acids to 45 amino acids, about 10 amino acids to 40 amino acids, about 10 amino acids to 35 amino acids, about 10 amino acids to 30 amino acids, about 10 amino acids to 25 amino acids, about 10 amino acids to 20 amino acids, about 10 amino acids to 15 amino acids, about 15 amino acids to 50 amino acids, about 15 amino acids to 45 amino acids, about 15 amino acids to 40 amino acids, about 15 amino acids to 35 amino acids, about 15 amino acids to 30 amino acids, about 15 amino acids to 25 amino acids, about 15 amino acids to 20 amino acids, about 20 amino acids to 50 amino acids, about 20 amino acids to 45 amino acids, about 20 amino acids to 40 amino acids, about 20 amino acids to 35 amino acids, about 20 amino acids to 30 amino acids, about 20 amino acids to 25 amino acids, about 25 amino acids to 50 amino acids, about 25 amino acids to 45 amino acids, about 25 amino acids to 40 amino acids, about 25 amino acids to 35 amino acids, about 25 amino acids to 30 amino acids, about 30 amino acids to 50 amino acids, about 30 amino acids to 45 amino acids, about 30 amino acids to 40 amino acids, about 30 amino acids to 35 amino acids, about 35 amino acids to 50 amino acids, about 35 amino acids to 45 amino acids, about 35 amino acids to 40 amino acids, about 40 amino acids to 50 amino acids, about 40 amino acids to 45 amino acids, or about 45 amino acids to about 50 amino acids, are inserted. In some examples, the 1 amino acid to 50 amino acids (or any subrange thereof) can be inserted as a contiguous sequence into the sequence of a wildtype, full-length protein. In some examples, the 1 amino acid to 50 amino acids (or any subrange thereof) are not inserted as a contiguous sequence into the sequence of a wildtype, full-length protein. As can be appreciated in the art, the 1 amino acid to 50 amino acids can be inserted into a portion of the sequence of a wildtype, full-length protein that is not well-conserved between species.

Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Methods and materials are described herein for use in the present invention; other suitable methods and materials known in the art can also be used. The materials, methods, and examples are illustrative only and not intended to be limiting. All publications, patent applications, patents, sequences, database entries, and other references mentioned herein are incorporated by reference in their entirety. In case of conflict, the present specification, including definitions, will control.

BRIEF DESCRIPTION OF DRAWINGS

FIG. 1A is a representative image of Myo7a/Iba-1 immunofluorescent staining of cochlear tissue of a cynomolgus macaque (non-human primate) following administration of a single Anc80-GFP AAV vector directly into the inner ear through the round window.

FIG. 1B is a representative image of Anc80-GFP immunofluorescent staining of the same cochlear tissue of the cynomolgus macaque as in FIG. 1A.

FIG. 1C is a representative image of a merged immunofluorescent staining of Myo7a/Iba-1 and Anc80-GFP of the same cochlear tissue of the cynomolgus macaque as in FIG. 1A.

DETAILED DESCRIPTION

Provided herein are compositions including two different nucleic acid vectors, where: a first nucleic acid vector of the two different nucleic acid vectors includes a promoter, a first coding sequence that encodes an N-terminal portion of a supporting cell target protein positioned 3′ of the promoter, and a splicing donor signal sequence positioned at the 3′ end of the first coding sequence; and a second nucleic acid vector of the two different nucleic acid vectors includes a splicing acceptor signal sequence, a second coding sequence that encodes a C-terminal portion of a supporting cell target protein positioned at the 3′ end of the splicing acceptor signal sequence, and a polyadenylation sequence at the 3′ end of the second coding sequence; where each of the encoded portions is at least 30 amino acid residues in length, where the amino acid sequences of the encoded portions do not overlap, where no single vector of the two different vectors encodes the full-length supporting cell target protein, and, when the coding sequences are transcribed in a primate cell, to produce RNA transcripts, splicing occurs between the splicing donor signal sequence on one transcript and the splicing acceptor signal sequence on the other transcript, thereby forming a recombined RNA molecule that encodes a full-length supporting cell target protein.

Provided herein are compositions including: a first nucleic acid vector including a promoter, a first coding sequence that encodes an N-terminal portion of a supporting cell target protein positioned 3′ of the promoter, a splicing donor signal sequence positioned at the 3′ end of the first coding sequence, and a first detectable marker gene positioned 3′ of the splicing donor signal sequence; and a second nucleic acid vector, different from the first nucleic acid vector, including a second detectable marker gene, a splicing acceptor signal sequence positioned 3′ of the second detectable marker gene, a second coding sequence that encodes a C-terminal portion of a supporting cell target protein positioned at the 3′ end of the splicing acceptor signal sequence, and a polyadenylation sequence positioned at the 3′ end of the second coding sequence; where each of the encoded portions is at least 30 amino acid residues in length, where the respective amino acid sequences of the encoded portions do not overlap with each other, where no single vector of the two different vectors encodes the full-length supporting cell target protein, and, when the coding sequences are transcribed in a primate cell to produce RNA transcripts, splicing occurs between the splicing donor signal on one transcript and the splicing acceptor signal on the other transcript, thereby forming a recombined RNA molecule that encodes a full-length supporting cell target protein.

Provided herein are compositions including: a first nucleic acid vector including a promoter, a first coding sequence that encodes an N-terminal portion of a supporting cell target protein positioned 3′ to the promoter, a splicing donor signal sequence positioned at the 3′ end of the first coding sequence, and a F1 phage recombinogenic region positioned 3′ to the splicing donor signal sequence; and a second nucleic acid vector, different from the first nucleic acid vector, including a second F1 phage recombinogenic region, a splicing acceptor signal sequence positioned 3′ of the second F1 phage recombinogenic region, a second coding sequence that encodes a C-terminal portion of a supporting cell target protein positioned at the 3′ end of the splicing acceptor signal sequence, and a polyadenylation sequence positioned at the 3′ end of the second coding sequence; where each of the encoded portions is at least 30 amino acid residues in length, where the respective amino acid sequences of the encoded portions do not overlap with each other, where no single vector of the two different vectors encodes the full-length supporting cell target protein, and, when the coding sequences are transcribed in a primate cell to produce RNA transcripts, splicing occurs between the splicing donor signal one transcript and the splicing acceptor signal on the other transcript, thereby forming a recombined RNA molecule that encodes a full-length supporting cell target protein.

Provided herein are compositions including a single adeno-associated virus (AAV) vector, where the single AAV vector that includes a nucleic acid sequence that encodes a supporting cell target protein; and when introduced into a primate cell, a nucleic acid encoding a full-length supporting cell target protein is generated at the locus of the supporting cell target gene, and the primate expresses the supporting cell target protein.

Provided herein are compositions that include at least two different nucleic acid vectors, where: each of the at least two different adeno-associated virus (AAV) vectors includes a coding sequence that encodes a different portion of a hair cell target protein, each of the encoded portions being at least 30 amino acid residues in length, where the amino acid sequence of each of the encoded portions may optionally partially overlap with the amino acid sequence of a different one of the encoded portions; no single vector of the at least two different vectors encodes the full-length hair cell target protein; at least one of the coding sequences includes a nucleotide sequence spanning two neighboring exons of the hair cell target genomic DNA, and lacks an intronic sequence between the two neighboring exons; and when introduced into a primate cell the at least two different vectors undergo concatamerization or homologous recombination with each other, thereby forming a recombined nucleic acid that encodes a full-length hair cell target protein.

Provided herein are compositions including two different nucleic acid vectors, where: a first nucleic acid vector of the two different nucleic acid vectors includes a promoter, a first coding sequence that encodes an N-terminal portion of a hair cell target protein positioned 3′ of the promoter, and a splicing donor signal sequence positioned at the 3′ end of the first coding sequence; and a second nucleic acid vector of the two different nucleic acid vectors includes a splicing acceptor signal sequence, a second coding sequence that encodes a C-terminal portion of a hair cell target protein positioned at the 3′ end of the splicing acceptor signal sequence, and a polyadenylation sequence at the 3′ end of the second coding sequence; where each of the encoded portions is at least 30 amino acid residues in length, where the amino acid sequences of the encoded portions do not overlap, where no single vector of the two different vectors encodes the full-length hair cell target protein, and, when the coding sequences are transcribed in a primate cell, to produce RNA transcripts, splicing occurs between the splicing donor signal sequence on one transcript and the splicing acceptor signal sequence on the other transcript, thereby forming a recombined RNA molecule that encodes a full-length hair cell target protein.

Provided herein are compositions including: a first nucleic acid vector including a promoter, a first coding sequence that encodes an N-terminal portion of a hair cell target protein positioned 3′ of the promoter, a splicing donor signal sequence positioned at the 3′ end of the first coding sequence, and a first detectable marker gene positioned 3′ of the splicing donor signal sequence; and a second nucleic acid vector, different from the first nucleic acid vector, including a second detectable marker gene, a splicing acceptor signal sequence positioned 3′ of the second detectable marker gene, a second coding sequence that encodes a C-terminal portion of a hair cell target protein positioned at the 3′ end of the splicing acceptor signal sequence, and a polyadenylation sequence positioned at the 3′ end of the second coding sequence; where each of the encoded portions is at least 30 amino acid residues in length, where the respective amino acid sequences of the encoded portions do not overlap with each other, where no single vector of the two different vectors encodes the full-length hair cell target protein, and, when the coding sequences are transcribed in a primate cell to produce RNA transcripts, splicing occurs between the splicing donor signal on one transcript and the splicing acceptor signal on the other transcript, thereby forming a recombined RNA molecule that encodes a full-length hair cell target protein.

Provided herein are compositions including: a first nucleic acid vector including a promoter, a first coding sequence that encodes an N-terminal portion of a hair cell target protein positioned 3′ to the promoter, a splicing donor signal sequence positioned at the 3′ end of the first coding sequence, and a F1 phage recombinogenic region positioned 3′ to the splicing donor signal sequence; and a second nucleic acid vector, different from the first nucleic acid vector, including a second F1 phage recombinogenic region, a splicing acceptor signal sequence positioned 3′ of the second F1 phage recombinogenic region, a second coding sequence that encodes a C-terminal portion of a hair cell target protein positioned at the 3′ end of the splicing acceptor signal sequence, and a polyadenylation sequence positioned at the 3′ end of the second coding sequence; where each of the encoded portions is at least 30 amino acid residues in length, where the respective amino acid sequences of the encoded portions do not overlap with each other, where no single vector of the two different vectors encodes the full-length hair cell target protein, and, when the coding sequences are transcribed in a primate cell to produce RNA transcripts, splicing occurs between the splicing donor signal one transcript and the splicing acceptor signal on the other transcript, thereby forming a recombined RNA molecule that encodes a full-length hair cell target protein.

Also provided herein are compositions including a single adeno-associated virus (AAV) vector, where the single AAV vector that includes a nucleic acid sequence that encodes a hair cell target protein; and when introduced into a primate cell, a nucleic acid encoding a full-length hair cell target protein is generated at the locus of the hair cell target gene, and the primate expresses the hair cell target protein.

Also provided are kits that include any of the compositions described herein. Also provided herein are methods that include introducing into a cochlea of a mammal a therapeutically effective amount of any of the compositions described herein.

Also provided are methods of correcting a supporting cell target gene defect in a supporting cell of an inner ear in a primate that include: administering to the inner ear of the primate a therapeutically effective amount of any of the compositions described herein, where the administering repairs the supporting cell target gene defect in the supporting cell of the inner ear of the primate.

Also provided are methods of correcting a hair cell target gene defect in a hair cell of an inner ear in a primate that include: administering to the inner ear of the primate a therapeutically effective amount of any of the compositions described herein, where the administering repairs the hair cell target gene defect in the hair cell of the inner ear of the primate.

Also provided herein are methods of treating hearing loss, e.g., non-syndromic sensorineural hearing loss or syndromic sensorineural hearing loss, in a primate identified as having a defective supporting cell target gene that include: administering to the inner ear of the primate a therapeutically effective amount of any of the compositions described herein.

Also provided herein are methods of treating hearing loss, e.g., non-syndromic sensorineural hearing loss or syndromic sensorineural hearing loss, in a primate identified as having a defective hair cell target gene that include: administering to the inner ear of the primate a therapeutically effective amount of any of the compositions described herein.

Also provided herein are methods that include administering to an inner ear of a primate a therapeutically effective amount of any of the compositions described herein.

Additional non-limiting aspects of the compositions, kits, and methods are described herein and can be used in any combination without limitation.

Gap Junction Protein Beta 2 (GJB2)

The GJB2 gene encodes gap junction protein beta 2, a member of the gap junction protein family. Gap junction proteins are specialized proteins, also called connexins, involved in intracellular communication. Mutations in GJB2 have been associated with hearing loss and deafness (Amorini et al., Ann. Hum. Genet. 79(5):341-349, 2015; Qing et al., Genet. Test Mol. Biomarkers 19(1):52-58, 2015).

The human GJB2 gene is located on chromosome 13q12. It contains 2 exons encompassing ˜5 kilobases (kb) (NCBI Accession No. NG008358.1). The full-length wildtype GJB2 protein expressed from the human GJB2 gene is 226 amino acids in length.

Various mutations in the GJB2 gene have been associated with hearing loss (e.g., non-syndromic sensorineural hearing loss or syndromic sensorineural hearing loss). For example, the c.35delG allele was found on 65.5% of patients from Eastern Sicily (Amorini et al., Ann. Hum. Genet. 79(5):341-349, 2015).

Additional exemplary mutations in a GJB2 gene detected in subjects having non-syndromic sensorineural hearing loss or syndromic sensorineural hearing loss, and methods of sequencing a nucleic acid encoding GJB2 are described in, e.g., Snoeckx et al., Am. J. Hum. Genet 77: 945-957, 2005; Welch et al., Am. J. Med. Genet A 143: 1567-1573, 2007; and Zelante et al., Hum. Mol. Genet. 6:1605-1609, 1997. Methods of detecting mutations in a gene are well-known in the art. Non-limiting examples of such techniques include: real-time polymerase chain reaction (RT-PCR), PCR, sequencing, Southern blotting, and Northern blotting.

An exemplary human wildtype GJB2 protein is or includes the sequence of SEQ ID NO: 1. Non-limiting examples of nucleic acid encoding a wildtype GJB2 protein are or include SEQ ID NO: 2. As can be appreciated in the art, at least some or all of the codons in SEQ ID NO: 2 can be codon-optimized to allow for optimal expression in a non-human mammal.

In some embodiments of any of the compositions described herein, the GJB2 protein comprises a sequence that is at least 75% (e.g., at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%) identical to SEQ ID NO: 1.

Human Full-length Wildtype GJB2 Protein

(SEQ ID NO: 1)

MDWGTLQTILGGVNKHSTSIGKIWLTVLFIFRIMILVVAAKEVWGDEQAD

FVCNTLQPGCKNVCYDHYFPISHIRLWALQLIFVSTPALLVAMHVAYRRH

EKKRKFIKGEIKSEFKDIEEIKTQKVRIEGSLWWTYTSSIFFRVIFEAAF

MYVFYVMYDGFSMQRLVKCNAWPCPNTVDCFVSRPTEKTVFTVFMIAVSG

ICILLNVTELCYLLIRYCSGKSKKPV

Human Wildtype GJB2 cDNA

(SEQ ID NO: 2)

atggattggggcacgctgcagacgatcctggggggtgtgaacaaacactc

caccagcattggaaagatctggctcaccgtcctcttcatttttcgcatta

tgatcctcgttgtggctgcaaaggaggtgtggggagatgagcaggccgac

tttgtctgcaacaccctgcagccaggctgcaagaacgtgtgctacgatca

ctacttccccatctcccacatccggctatgggccctgcagctgatcttcg

tgtccacgccagcgctcctagtggccatgcacgtggcctaccggagacat

gagaagaagaggaagttcatcaagggggagataaagagtgaatttaagga

catcgaggagatcaaaacccagaaggtccgcatcgaaggctccctgtggt

ggacctacacaagcagcatcttcttccgggtcatcttcgaagccgccttc

atgtacgtcttctatgtcatgtacgacggcttctccatgcagcggctggt

gaagtgcaacgcctggccttgtcccaacactgtggactgctttgtgtccc

ggcccacggagaagactgtcttcacagtgttcatgattgcagtgtctgga

atttgcatcctgctgaatgtcactgaattgtgttatttgctaattagata

ttgttctgggaagtcaaaaaagccagtttaa

A non-limiting example of a human wildtype GJB2 genomic DNA sequence is SEQ ID NO: 3. The exons in SEQ ID NO: 3 are: nucleotide positions 1-156 (exon 1), and nucleotide positions 3336-5469 (exon 2). The intron is located between each of these exons in SEQ ID NO: 3, i.e., at nucleotide positions 157-3335 (intron 1).

Human Wildtype GJB2 Gene Sequence (NCBI Reference Sequence: NG_008358.1)

(SEQ ID NO: 3)

1
ggggtgcggt taaaaggcgc cacggcggga gacaggtgtt gcggccccgc agcgcccgcg

61
cgctcctctc cccgactcgg agcccctcgg cggcgcccgg cccaggaccc gcctaggagc

121
gcaggagccc cagcgcagag accccaacgc cgagaccccc gccccggccc cgccgcgctt

181
cctcccgacg caggtgagcc cgccggcccc ggactgcccg gccaggaacc tggcgcgggg

241
agggaccgcg agacccagag cggttgcccg gccgcgtggg tctcggggaa ccggggggct

301
ggaccaacac acgtccttgg gccggggggc gggggccgcc ttctggagcg ggcgtttctg

361
cggccgagct ccggagctgg aatggggcgg ccggggaagt ggacgcgatg gcaccgcccg

421
gggtgcgagt ggggccgggc gcgcgcggga ggggaaaaag gcgcgggcga gccgccagcg

481
cgaggtttgt ggtgtcgccg atgtcccttc ggggtactct agcgcagccg cctggctact

541
tgacccactg ccaccaaacg ttttaaattc accgaaagct tagcttcgaa gcaaagctcc

601
gtttcgccgg tgaagcagga agccttcgct gcaggaactg acctttacct cttggagcgg

661
cttctgcaga aaaatccccg ggcagagatt tgggcggagt ttgcctagaa ctaacgcgga

721
gccagccgat cccggcctac cccggggcca agatttcagt ggcttccctt tttcctaaac

781
acttcacgag ggtctgtttc cgggctgtgc tccccgccta gaaggaaaat ttttaggacc

841
cttgttcgcg aagaggtggt gtgcggctga gacccgcgtc ctcaggacgg ttccatcagt

901
gcctcgatcc tgccccactg gaggaggaag gcagcccgaa cagcgctcac ctaactaaca

961
gctgctgaga gctgggttcc gtggccatgc acctgggact gccttgagaa gcgtggtacg

1021
gccgtgtccc catgtgacct tagagtccct ttcgaaactg ctgtgcacag tcggtcacaa

1081
tttcagacac tggtgagaag ggtggaggaa ccctctgggg acagccaggc aaggtcgacc

1141
acccatcacc taagggtgga gaaatttaag gggtgaagag tcccttttgc cttttctgga

1201
tcctggtgat tcacctagtg tcttccctaa ggaactgaac caactcctcc gctggcctct

1261
ggcagccctc caggcggtgc aggatggcgt gggcccggta ggaagctgca tgtaaccgcc

1321
cagggtcggg aggccaggag ggcagctcct cctctgactt gaatattgaa aacaacttcg

1381
tcctgcttct gagcccctct taacccatga ccccctagcc cattggggag taaatcttaa

1441
tttactcctc ttcctgaaaa aggatcttta aaacaggtag cttcaactca agctttataa

1501
aataacaata tagggtttct cggaactgta tttttctcag ctgatggtaa ctggacaggt

1561
ctgtagaagg gtgtatgacc tgggtttggc aggtggaaga gggcaaagga taaacccctc

1621
ctcctgcagc cccatattct tggccaggtg tattgttgta aaccaggaga gagtttactt

1681
cggggagtat cctgttttcc actcagtgag ggccaatgaa gaatgtctaa ttccataaga

1741
tgcttttgtt aaaatcggaa tgttgctgtc ctcggtggtt ctgctgttgg gacgggactg

1801
gcctgagctg tgggtgctgt agcaggacaa ccagctcacc taagggcctc ccagtctgga

1861
ttatcaatgg gtcagtgctg aacctgggct aaaatattgt tttttccaat gatgttgtct

1921
ttcccaagct cagtgaagct aaatgtttca caggcctatg tcaatctgat gtaactttcg

1981
tggccacctc tctcctgtta gcctctgacc aaggtggcac tggatggttt ctgcctgacc

2041
ttggtgcccc gtggcagcga ctgtgggtca tgaaagacat tcactacgag cctgcttctg

2101
gagtccatca gaaaacggga tgcaacttgc ctaaaatgag gagaggagga tgcttttaag

2161
aaaaagaaga aggaggattc actaccagct ctgaagggtg gaaaagagat gattcatccg

2221
gattgtggag agggtggaat cttgtttagg agagcgttgg ttgtggcagg cagggtgtaa

2281
ctatgaatca gtgaagacaa ttcacatcct gggatgaaaa gaaggccatg ggctcacagg

2341
agattatcca ctggcctctc cacatccgct tgcagtaagg agtgtgggac tctcccaagc

2401
ttcagcgctg aactgcaatg cagtgacgtc gcttagctgg gccagtaacc gagggagttg

2461
aattttctgt cattttaaaa taatgtgtct tttaagaaac actttgaaat taaaaccaca

2521
gcccacaatt ataatgcact gttgcagcac ttatcaaaac agatatgcta actgagccat

2581
cagtgccagc ctgacagtga ggccaccaag ccatccacaa agcctacacg aaagtctgtg

2641
ctcacagtgg cttttctcca tgaagagggc attcctaacc tcttcctttc acgtaggagg

2701
aagcaaggtc ctttgtaaaa ttttaactcg gggtgcctca aatgtaaact taaccactgg

2761
taacaacagt ttcactgcta catgccacgt ctgtgaaaat tcattcaaga cattaaggaa

2821
agtggctcag cagagagact agacatctta tcctcacggt tctcctgtac ttggcctctc

2881
agcctttgag caaggttggc ccaagctagt atcggcccca gtggtacagc caaaacttga

2941
gactgcaaat ggatgcagct gttgaacgct gagtaacttc tgcagagtca ggaagaccca

3001
aggaagctct gcagaggatg caggggtacg gtcagaaccc ctgagtgcct ttcagctaac

3061
gaggacttta tgacactccc cagcacagca aatttttatg atgtgtttaa agattgggtg

3121
aattactcag gtgaacaagc tactttttat cagagaacac ctaaaaacac gttcaagagg

3181
gtttgggaac tatacattta atcctatgac aaactaagtt ggttctgtct tcacctgttt

3241
tggtgaggtt gtgtaagagt tggtgtttgc tcaggaagag atttaagcat gcttgcttac

3301
ccagactcag agaagtctcc ctgttctgtc ctagctagtg attcctgtgt tgtgtgcatt

3361
cgtcttttcc agagcaaacc gcccagagta gaagatggat tggggcacgc tgcagacgat

3421
cctggggggt gtgaacaaac actccaccag cattggaaag atctggctca ccgtcctctt

3481
catttttcgc attatgatcc tcgttgtggc tgcaaaggag gtgtggggag atgagcaggc

3541
cgactttgtc tgcaacaccc tgcagccagg ctgcaagaac gtgtgctacg atcactactt

3601
ccccatctcc cacatccggc tatgggccct gcagctgatc ttcgtgtcca cgccagcgct

3661
cctagtggcc atgcacgtgg cctaccggag acatgagaag aagaggaagt tcatcaaggg

3721
ggagataaag agtgaattta aggacatcga ggagatcaaa acccagaagg tccgcatcga

3781
aggctccctg tggtggacct acacaagcag catcttcttc cgggtcatct tcgaagccgc

3841
cttcatgtac gtcttctatg tcatgtacga cggcttctcc atgcagcggc tggtgaagtg

3901
caacgcctgg ccttgtccca acactgtgga ctgctttgtg tcccggccca cggagaagac

3961
tgtcttcaca gtgttcatga ttgcagtgtc tggaatttgc atcctgctga atgtcactga

4021
attgtgttat ttgctaatta gatattgttc tgggaagtca aaaaagccag tttaacgcat

4081
tgcccagttg ttagattaag aaatagacag catgagaggg atgaggcaac ccgtgctcag

4141
ctgtcaaggc tcagtcgcta gcatttccca acacaaagat tctgacctta aatgcaacca

4201
tttgaaaccc ctgtaggcct caggtgaaac tccagatgcc acaatggagc tctgctcccc

4261
taaagcctca aaacaaaggc ctaattctat gcctgtctta attttctttc acttaagtta

4321
gttccactga gaccccaggc tgttaggggt tattggtgta aggtactttc atattttaaa

4381
cagaggatat cggcatttgt ttctttctct gaggacaaga gaaaaaagcc aggttccaca

4441
gaggacacag agaaggtttg ggtgtcctcc tggggttctt tttgccaact ttccccacgt

4501
taaaggtgaa cattggttct ttcatttgct ttggaagttt taatctctaa cagtggacaa

4561
agttaccagt gccttaaact ctgttacact ttttggaagt gaaaactttg tagtatgata

4621
ggttattttg atgtaaagat gttctggata ccattatatg ttccccctgt ttcagaggct

4681
cagattgtaa tatgtaaatg gtatgtcatt cgctactatg atttaatttg aaatatggtc

4741
ttttggttat gaatactttg cagcacagct gagaggctgt ctgttgtatt cattgtggtc

4801
atagcaccta acaacattgt agcctcaatc gagtgagaca gactagaagt tcctagtgat

4861
ggcttatgat agcaaatggc ctcatgtcaa atatttagat gtaattttgt gtaagaaata

4921
cagactggat gtaccaccaa ctactacctg taatgacagg cctgtccaac acatctccct

4981
tttccatgac tgtggtagcc agcatcggaa agaacgctga tttaaagagg tcgcttggga

5041
attttattga cacagtacca tttaatgggg aggacaaaat ggggcagggg agggagaagt

5101
ttctgtcgtt aaaaacagat ttggaaagac tggactctaa agtctgttga ttaaagatga

5161
gctttgtcta cttcaaaagt ttgtttgctt accccttcag cctccaattt tttaagtgaa

5221
aatatagcta ataacatgtg aaaagaatag aagctaaggt ttagataaat attgagcaga

5281
tctataggaa gattgaacct gaatattgcc attatgcttg acatggtttc caaaaaatgg

5341
tactccacat atttcagtga gggtaagtat tttcctgttg tcaagaatag cattgtaaaa

5401
gcattttgta ataataaaga atagctttaa tgatatgctt gtaactaaaa taattttgta

5461
atgtatcaaa tacatttaaa acattaaaat ataatctcta taataattta aaa

Solute Carrier Family 26 Member 4 (SLC26A4)

The SLC26A4 gene encodes the Pendred protein, and has homology to sulfate transporters. Mutations in SLC26A4 have been associated with hearing loss and deafness (Albert et al., Eur. J. Hum. Genet. 14:773-779, 2006; and Qing et al., Genet. Test Mol. Biomarkers 19(1):52-58, 2015).

The human SLC26A4 gene is located on chromosome 7q22. It contains 21 exons encompassing ˜57 kilobases (kb) (NCBI Accession No. NG_008489.1). The full-length wildtype SLC26A4 protein expressed from the human SLC26A4 gene is 780 amino acids in length.

Various mutations in the SLC26A4 gene have been associated with hearing loss. For example, point mutations V250A, D266N, E303Q, F345S, D697, K715N, and E737D have been reported in Chinese and U.S. patients with non-syndromic hearing loss (Dai et al., Physiol Genomics 38(3): 281-290, 2015).

Additional exemplary mutations in a SLC26A4 gene detected in subjects having non-syndromic sensorineural hearing loss or syndromic sensorineural hearing loss, and methods of sequencing a nucleic acid encoding SLC26A4 are described in, e.g., Albert et al., Eur. J. Hum. Genet. 14: 773-779, 2006; and Qing et al., Genet. Test Mol. Biomarkers 19(1):52-58, 2015. Methods of detecting mutations in a gene are well-known in the art. Non-limiting examples of such techniques include: real-time polymerase chain reaction (RT-PCR), PCR, sequencing, Southern blotting, and Northern blotting.

An exemplary human wildtype SLC26A4 protein is or includes the sequence of SEQ ID NO: 4. Non-limiting examples of nucleic acid encoding a wildtype SLC26A4 protein are or include SEQ ID NO: 5 or 6. As can be appreciated in the art, at least some or all of the codons in SEQ ID NO: 5 or 6 can be codon-optimized to allow for optimal expression in a non-human mammal.

In some embodiments of any of the compositions described herein, the SLC26A4 protein comprises a sequence that is at least 75% (e.g., at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%) identical to SEQ ID NO: 4.

Human Full-length Wildtype SLC26A4 Protein

(SEQ ID NO: 4)

MAAPGGRSEPPQLPEYSCSYMVSRPVYSELAFQQQHERRLQERKTLRESLAKCCSCSRKRAFGVLKTLVPI

LEWLPKYRVKEWLLSDVISGVSTGLVATLQGMAYALLAAVPVGYGLYSAFFPILTYFIFGTSRHISVGPFP

VVSLMVGSVVLSMAPDEHFLVSSSNGTVLNTTMIDTAARDTARVLIASALTLLVGIIQLIFGGLQIGFIVR

YLADPLVGGFTTAAAFQVLVSQLKIVLNVSTKNYNGVLSIIYTLVEIFQNIGDTNLADFTAGLLTIVVCMA

VKELNDRFRHKIPVPIPIEVIVTIIATAISYGANLEKNYNAGIVKSIPRGFLPPELPPVSLFSEMLAASFS

IAVVAYAIAVSVGKVYATKYDYTIDGNQEFIAFGISNIFSGFFSCFVATTALSRTAVQESTGGKTQVAGII

SAAIVMIAILALGKLLEPLQKSVLAAVVIANLKGMFMQLCDIPRLWRQNKIDAVIWVFTCIVSIILGLDLG

LLAGLIFGLLTVVLRVQFPSWNGLGSIPSTDIYKSTKNYKNIEEPQGVKILRFSSPIFYGNVDGFKKCIKS

TVGFDAIRVYNKRLKALRKIQKLIKSGQLRATKNGIISDAVSTNNAFEPDEDIEDLEELDIPTKEIEIQVD

WNSELPVKVNVPKVPIHSLVLDCGAISFLDVVGVRSLRVIVKEFQRIDVNVYFASLQDYVIEKLEQCGFFD

DNIRKDTFFLTVHDAILYLQNQVKSQEGQGSILETITLIQDCKDTLELIETELTEEELDVQDEAMRTLAS

Exemplary Human Wildtype SLC26A4 cDNA

(SEQ ID NO: 5)

atggcagcgccaggcggcaggtcggagccgccgcagctccccgagtacagctgcagctacatggtgtcgcg

gccggtctacagcgagctcgctttccagcaacagcacgagcggcgcctgcaggagcgcaagacgctgcggg

agagcctggccaagtgctgcagttgttcaagaaagagagcctttggtgtgctaaagactcttgtgcccatc

ttggagtggctccccaaataccgagtcaaggaatggctgcttagtgacgtcatttcgggagttagtactgg

gctagtggccacgctgcaagggatggcatatgccctactagctgcagttcctgtcggatatggtctctact

ctgcttttttccctatcctgacatactttatctttggaacatcaagacatatctcagttggaccttttcca

gtggtgagtttaatggtgggatctgttgttctgagcatggcccccgacgaacactttctcgtatccagcag

caatggaactgtattaaatactactatgatagacactgcagctagagatacagctagagtcctgattgcca

gtgccctgactctgctggttggaattatacagttgatatttggtggcttgcagattggattcatagtgagg

tacttggcagatcctttggttggtggcttcacaacagctgctgccttccaagtgctggtctcacagctaaa

gattgtcctcaatgtttcaaccaaaaactacaatggagttctctctattatctatacgctggttgagattt

ttcaaaatattggtgataccaatcttgctgatttcactgctggattgctcaccattgtcgtctgtatggca

gttaaggaattaaatgatcggtttagacacaaaatcccagtccctattcctatagaagtaattgtgacgat

aattgctactgccatttcatatggagccaacctggaaaaaaattacaatgctggcattgttaaatccatcc

caagggggtttttgcctcctgaacttccacctgtgagcttgttctcggagatgctggctgcatcattttcc

atcgctgtggtggcttatgctattgcagtgtcagtaggaaaagtatatgccaccaagtatgattacaccat

cgatgggaaccaggaattcattgcctttgggatcagcaacatcttctcaggattcttctcttgttttgtg

gccaccactgctctttcccgcacggccgtccaggagagcactggaggaaagacacaggttgctggcatcat

ctctgctgcgattgtgatgatcgccattcttgccctggggaagcttctggaacccttgcagaagtcggtct

tggcagctgttgtaattgccaacctgaaagggatgtttatgcagctgtgtgacattcctcgtctgtggaga

cagaataagattgatgctgttatctgggtgtttacgtgtatagtgtccatcattctggggctggatctcgg

tttactagctggccttatatttggactgttgactgtggtcctgagagttcagtttccttcttggaatggcc

ttggaagcatccctagcacagatatctacaaaagtaccaagaattacaaaaacattgaagaacctcaagga

gtgaagattcttagattttccagtcctattttctatggcaatgtcgatggttttaaaaaatgtatcaagtc

cacagttggatttgatgccattagagtatataataagaggctgaaagcgctgaggaaaatacagaaactaa

taaaaagtggacaattaagagcaacaaagaatggcatcataagtgatgctgtttcaacaaataatgctttt

gagcctgatgaggatattgaagatctggaggaacttgatatcccaaccaaggaaatagagattcaagtgga

ttggaactctgagcttccagtcaaagtgaacgttcccaaagtgccaatccatagccttgtgcttgactgt

ggagctatatctttcctggacgttgttggagtgagatcactgcgggtgattgtcaaagaattccaaagaat

tgatgtgaatgtgtattttgcatcacttcaagattatgtgatagaaaagctggagcaatgcgggttctttg

acgacaacattagaaaggacacattctttttgacggtccatgatgctatactctatctacagaaccaagtg

aaatctcaagagggtcaaggttccattttagaaacgatcactctcattcaggattgtaaagatacccttga

attaatagaaacagagctgacggaagaagaacttgatgtccaggatgaggctatgcgtacacttgcatcct

ga

Exemplary Human Wildtype SLC26A4 cDNA

(SEQ ID NO: 6)

ctcagccttcccggttcgggaaaggggaagaatgcaggaggggtaggatttctttcctgataggatcggtt

gggaaagaccgcagcctgtgtgtgtctttcccttcgaccaaggtgtctgttgctccgtaaataaaacgtcc

cactgccttctgagagcgctataaaggcagcggaagggtagtccgcggggcattccgggcggggcgcgagc

agagacaggtcatggcagcgccaggcggcaggtcggagccgccgcagctccccgagtacagctgcagctac

atggtgtcgcggccggtctacagcgagctcgctttccagcaacagcacgagcggcgcctgcaggagcgcaa

gacgctgcgggagagcctggccaagtgctgcagttgttcaagaaagagagcctttggtgtgctaaagactc

ttgtgcccatcttggagtggctccccaaataccgagtcaaggaatggctgcttagtgacgtcatttcggga

gttagtactgggctagtggccacgctgcaagggatggcatatgccctactagctgcagttcctgtcggata

tggtctctactctgcttttttccctatcctgacatactttatctttggaacatcaagacatatctcagttg

gaccttttccagtggtgagtttaatggtgggatctgttgttctgagcatggcccccgacgaacactttctc

gtatccagcagcaatggaactgtattaaatactactatgatagacactgcagctagagatacagctagagt

cctgattgccagtgccctgactctgctggttggaattatacagttgatatttggtggcttgcagattggat

tcatagtgaggtacttggcagatcctttggttggtggcttcacaacagctgctgccttccaagtgctggtc

tcacagctaaagattgtcctcaatgtttcaaccaaaaactacaatggagttctctctattatctatacgct

ggttgagatttttcaaaatattggtgataccaatcttgctgatttcactgctggattgctcaccattgtcg

tctgtatggcagttaaggaattaaatgatcggtttagacacaaaatcccagtccctattcctatagaagta

attgtgacgataattgctactgccatttcatatggagccaacctggaaaaaaattacaatgctggcattgt

taaatccatcccaagggggtttttgcctcctgaacttccacctgtgagcttgttctcggagatgctggctg

catcattttccatcgctgtggtggcttatgctattgcagtgtcagtaggaaaagtatatgccaccaagtat

gattacaccatcgatgggaaccaggaattcattgcctttgggatcagcaacatcttctcaggattcttctc

ttgttttgtggccaccactgctctttcccgcacggccgtccaggagagcactggaggaaagacacaggttg

ctggcatcatctctgctgcgattgtgatgatcgccattcttgccctggggaagcttctggaacccttgcag

aagtcggtcttggcagctgttgtaattgccaacctgaaagggatgtttatgcagctgtgtgacattcctcg

tctgtggagacagaataagattgatgctgttatctgggtgtttacgtgtatagtgtccatcattctggggc

tggatctcggtttactagctggccttatatttggactgttgactgtggtcctgagagttcagtttccttct

tggaatggccttggaagcatccctagcacagatatctacaaaagtaccaagaattacaaaaacattgaaga

acctcaaggagtgaagattcttagattttccagtcctattttctatggcaatgtcgatggttttaaaaaat

gtatcaagtccacagttggatttgatgccattagagtatataataagaggctgaaagcgctgaggaaaata

cagaaactaataaaaagtggacaattaagagcaacaaagaatggcatcataagtgatgctgtttcaacaaa

taatgcttttgagcctgatgaggatattgaagatctggaggaacttgatatcccaaccaaggaaatagaga

ttcaagtggattggaactctgagcttccagtcaaagtgaacgttcccaaagtgccaatccatagccttgtg

cttgactgtggagctatatctttcctggacgttgttggagtgagatcactgcgggtgattgtcaaagaatt

ccaaagaattgatgtgaatgtgtattttgcatcacttcaagattatgtgatagaaaagctggagcaatgcg

ggttctttgacgacaacattagaaaggacacattctttttgacggtccatgatgctatactctatctacag

aaccaagtgaaatctcaagagggtcaaggttccattttagaaacgatcactctcattcaggattgtaaaga

tacccttgaattaatagaaacagagctgacggaagaagaacttgatgtccaggatgaggctatgcgtacac

ttgcatcctgaaagtgggttcgggaggtctctatgagcaaggaatacaagacaaaacttcctcaatgcatt

gactatttcttcagactcaaaacactcattcttttttctattaagccattgaaagagaagcactaagactg

cttctaggctttatttataaaataaacaccttatccctaacatgggcaaaatggctagaattattcagacg

atttggcagcgtccagggtaagctggtgttataatacgctgctgatctacatcacagatttgctaataatg

ttcacgtgggccctggcatatctctgttcagttagagtgagtgctgacccaacagcctctgtggtcaagcg

agtcacgaatgattaatcataaagaaaaatcagtttttgactgacctggatatccatgagctgcactgatc

accatgtaaggtcacatttagtaaatgctgaaataaaatgattaatgcatttatcaataaaagcctttgaa

aatactttggataataaattggagttttaaaaatgcaaatttgcttagtatctaataatgaagtgttatta

catatagccggaattgaggatctctttgatcctggaaatggtttacctaaaagctacagaaccaggccaat

atattttgaaatattgatgcagacaaatgaaataataaagagattttcatggtttataaaaatcttttttg

atatgataataatcatgatcacaactgagatcaaaaaaatatatgacagattattttgtttaaaaatgcag

ttttaattatcttagtctatagaaatgatcattgcatggaggcatgtataggtatgatctgtgtaaaatct

gacataaaaacagtgctattctgagtgaaaatttttttgatgtgcttacataaccatggtgattaaaatga

gtttatattttttctcaaaaattttagcagtgtgtaaagtaagtaatctttaactgaactctgaccactta

aaaaaaaatctaaaaattgaactacctatagtagtctgtgtttaaagtgaatttttaaagacaaagcattc

taaatgaactcaatataaaaacattcatttggaatgtacatactgaaaaatacaggtttttttgaccaaaa

gtttttatatcttttctttttatttatttttttcctaagtgccaacaattttctagatattatatacaaca

caggctttgatcttggggacttttcccatatatttcacactggagtgaatgaagttgtacttcatttctag

agaaaagttatacccaggtccccaattgagaatgtcttgcttgattgaaaacgacatcatcccttggtata

ctccagggattggtttcaggacccctgcatttaccaaaatttgtgcacactcaagtcctgcagtcacccct

gcctaaagatagaatggcttctctgtttttcttctgaaatacaaccagaaacaatgtgtctatttctgaaa

gaataggattaatgatcatacaaatgggttaatcctgaattctggttgtaaatctggttacagcataacta

ggattataatgctgcctcattttcacagcactacttgcttatattgacaacaaatcatctcgctaaagagt

gaatgtaggccaggcgcggtggctcatgcctgtaatcccagcactttgggaggccgaggcgggtggatcac

gaggtcaggagatcgagaccatcctggctaacatggtaaaaccccgtctctactaaaaatagaaaaaaaga

aattagcctagcgtggtggctggcgggcgcctgtagtcccagctatttgggaggctaaggcaggagaatgg

cgtgaacccgggaggcggagcttgcagtgagccgaggtcgtgccactgcactccagcctgggcgacagagc

aagactccgtctcaaaaaaaaaaaaaaaaaaaaaaaaagagtgaatgtaatagtcttgcagaaaatgaatg

aatacctttgttcaataaaggaaatatgcactgctcacttttttgaaggaaatgccaaagttacgttttac

aacaaggctagagtttgtaaattctgggttcatttgtgatgacataagtcagcaaactgcgggaatactgt

ctcttctatgtattttgtgaatagtaagcataattttagttttgtattatcaatgaaaatttcacttgaaa

ttaaagctgccttttgttatatttttaacctataggataagattccagtattgtatatgagttttaacaaa

ttaaaaaatcaaatcatgtacatttgaaaatatttgcacacatttaaaaataaatgtaaagttgtctttta

aactactcggatgtgtcctttctgaacaa

A non-limiting example of a human wildtype SLC26A4 genomic is SEQ ID NO: 7. The exons in SEQ ID NO: 7 are: nucleotide positions 1-221 (exon 1), nucleotide positions 1005-1171 (exon 2), nucleotide positions 2262-2801 (exon 3), nucleotide positions 11504-11614 (exon 4), nucleotide positions 13530-13714 (exon 5), nucleotide positions 14311-14475 (exon 6), nucleotide positions 22568-22720 (exon 7), nucleotide positions 22821-22903 (exon 8), nucleotide positions 28419-28566 (exon 9), nucleotide positions 29490-29603 (exon 10), nucleotide positions 33769-33846 (exon 11), nucleotide positions 33987-34082 (exon 12), nucleotide positions 35299-35405 (exon 13), nucleotide positions 37408-37477 (exon 14), nucleotide positions 39449-39541 (exon 15), nucleotide positions 40467-40562 (exon 16), nucleotide positions 41193-41423 (exon 17), nucleotide positions 43697-43751 (exon 18), nucleotide positions 49420-49565 (exon 19), nucleotide positions 51905-51988 (exon 20) and nucleotide positions 56348-57175 (exon 21). The introns are located between each of these exons in SEQ ID NO: 7, i.e., at nucleotide positions 222-1004 (intron 1), nucleotide positions 1172-2261 (intron 2), nucleotide positions 2802-11503 (intron 3), nucleotide positions 11615-13529 (intron 4), nucleotide positions 13715-14310 (intron 5), nucleotide positions 14476-22567 (intron 6), nucleotide positions 22721-22820 (intron 7), nucleotide positions 22904-28418 (intron 8), nucleotide positions 28567-29489 (intron 9), nucleotide positions 29604-33768 (intron 10), nucleotide positions 33847-33986 (intron 11), nucleotide positions 34083-35298 (intron 12), nucleotide positions 35406-37407 (intron 13), nucleotide positions 37478-39448 (intron 14), nucleotide positions 39542-40466 (intron 15), nucleotide positions 40563-41192 (intron 16), nucleotide positions 41424-43696 (intron 17), nucleotide positions 43752-49419 (intron 18), nucleotide positions 49566-51904 (intron 19), and nucleotide positions 51989-56347 (intron 20).

Human Wildtype SLC26A4 Gene Sequence (NCBI Reference Sequence: NG_008489.1)

(SEQ ID NO: 7)

1
ctcagccttc ccggttcggg aaaggggaag aatgcaggag gggtaggatt tctttcctga

61
taggatcggt tgggaaagac cgcagcctgt gtgtgtcttt cccttcgacc aaggtgtctg

121
ttgctccgta aataaaacgt cccactgcct tctgagagcg ctataaaggc agcggaaggg

181
tagtccgcgg ggcattccgg gcggggcgcg agcagagaca ggtgagttcg ccctgaagat

241
gcccacaccg cccggcccgg gctccactcc cggggaggcc tcgagggttg cggatgggac

301
tcttaagtgg tcacggatca ggtgggcagg gggcagtaca gctttctttc tgagacgccg

361
agagcgaaca ggctgctcgg aaaacaggac gaggggagag acttgctcaa taagctgaaa

421
gttctgcccc cgagagggct gcgacagctg ctggaatgtg cctgcagcgt ccgcctcttg

481
gggacccgcg gagcgcgccc tgacggttcc acgcctggcc cgggggtctg cacctctcct

541
ccagtgcgca cctggagctg cgtcccgggt caggtgcggg gagggaggga atctcagtgt

601
ccccttccag ccttgcaagc gcctttggcc cctgccccag cccctcggtt tgggggagat

661
ttcagaacgc ggacagcgcc ctggctgcgg gccatagggg actgggtgga actcgggaag

721
cccccagagc aggggcttac tcgcttcaag tttggggaac cccgggcagc gggtgcaggc

781
cacgagaccc gaaggttctc aggtgccccc ctgcaggctg gccgtgcgcg ccgtggggcg

841
cttgtcgcga gcgccgaggg ctgcaggacg cggaccagac tcgcggtgca ggggggcctg

901
gctgcagcta acaggtgatc ccgttctttc tgttcctcgc tcttcccctc cgatcgtcct

961
cgcttaccgc gtgtcctccc tcctcgctgt cctctggctc gcaggtcatg gcagcgccag

1021
gcggcaggtc ggagccgccg cagctccccg agtacagctg cagctacatg gtgtcgcggc

1081
cggtctacag cgagctcgct ttccagcaac agcacgagcg gcgcctgcag gagcgcaaga

1141
cgctgcggga gagcctggcc aagtgctgca ggtagcggcc gcgcgggcct gcgtagagag

1201
aagcggagcg gggcgtccac gccttgggga gggaagggcg tccccagcgg gcgagagtgg

1261
ggtgcgggcg gcggagcccc tgggcgccag ctgcttctcc cagaggcccg actttcggtc

1321
tccggtcctc cacgccgccc ttctggtggg agggtggctc catcagtctc gggcccgaaa

1381
tgaacttacc tgggaaactc gcctttgggg agagtgggtt ctaggagccc cgtctctctt

1441
tttcctctct gaaggaaact tggagtgcct cttggggtac agtgggtccc tgttgccttc

1501
ttgggagctt gtttaaatga aatgaatagg gaaacccagc tcttgaccag gaggagtcct

1561
tgaaacactc aagctaagta ggcgggctac cattcagtta gagaccagga tgcaagctag

1621
aacccagggg agcgcggggt gtgccaagta cttcatcagc aggctgtggg acccctgggg

1681
aaagccaccc tcagtctcta aacccaaaca tgccgtaact agatgtcaca aacataaaga

1741
aattagagtt tctaaaacct ttcattatag aacatttcaa atatatgcat aagtagacgt

1801
agtagtataa tgaactcccc acccccaccg tttttaaccc atcactcggc ctcaactgtg

1861
atcaaatcca agttactctt gtttcttgta tctacaccta cttgctccct ccagtattat

1921
ttttaagcaa atctcatata gcatactgtc tttatgtatt ttactgcata tctttaaaga

1981
ctcttaaaaa atataaccac atttcatgat cacaccttaa tatctaaaaa taacctccta

2041
atatcaaaaa ttgagtcatt attaaaatgt ccaatcgtcc cataaatgcc ttaattaaaa

2101
aacaatttat tcaaatcagg agttatacca cctacttttg atatttttct ttcatctgta

2161
ggtcactgaa tttaaaaact accaagtagc aaggtataag gtatacattc ctcatgctaa

2221
gatttttgta aaaactagct ccaggcttgt attgccaaaa tatactcagt gtgtttatct

2281
tctttaaaga aaataataat aataaggcgc ctggattagg agtctgaaaa gtaatctcca

2341
tttagagact ccacatccat cagtctctgg ctggaccaga aaataggttt ttgtgtagga

2401
atattttttc agaggattaa aaatgtgagc gaggggtggg acacttaatc ctgtgttctc

2461
tagaagagtg catttaaaag gatagataca gttcttggca aaagcatggt aagcacttca

2521
gggttattat tttccaggaa atacttatcc tttttccaaa tagttataaa catcagcaga

2581
atccagttca taactttgtg atttgcaaat tggttgtgac tgagattgga ttgaaaaccc

2641
agttttcttg ctttttgaca gttgttcaag aaagagagcc tttggtgtgc taaagactct

2701
tgtgcccatc ttggagtggc tccccaaata ccgagtcaag gaatggctgc ttagtgacgt

2761
catttcggga gttagtactg ggctagtggc cacgctgcaa ggtaagatgt tggcagattg

2821
agagttctgg tctccagcag gagtttaaca cttctcccca gctaccatag gtctgtgaca

2881
gatggttgct tacccttcaa ggcctgtatc tttcctgtag agccccttag tggagagagt

2941
cacctctctt ctccccttcc ttagagttct cttcctggga aactgctgcc ccactaggtg

3001
cagaggtcca atttagaggc atatactagg cagtggcttc tcaatttttt taaattttat

3061
tttatttgag acgggggctc gctctgtcac ctaggctgga gtgcagtggc gcaatcctgg

3121
ctcactgcaa gctccgtctc ccgggttcac gccattctcc cgcctcagcc tccccagtag

3181
ctgggactac aggcgcccgc cactacgccc ggctaatttt ttgtattttt agtagagacg

3241
gggtttcacc gggttagcca ggatggtatc gacctcctga cctcgtgatc cgcctgcctt

3301
ggcctcccaa aatgctggga ttacaggcgt gagccactgc acccagccag cttctctatt

3361
ttcattgacc acaattcaat aagaaatgtg taaagagttt caagtcaaga tttaaaaaaa

3421
aaaaagaaat gtgttacatc ctgatatata catatatatc taaagttcct gtgaaatatt

3481
tattataaca atgtgctaat ctttcacttt gttctattat gcttaggttt tttaaatgat

3541
gattgcagca cattaaatta ttttatatcc acacgtggat cttttttgtt ggtttgtttt

3601
gctttgcttt ttagagatac agtcttgctc tgtcacccag gctggtgtgc agtggcacga

3661
tcttggctca atgcaacctc tctgcctctc gggttcaagt gattcttgtg cctcagcctt

3721
ctgagtagct ggggctacag gcatgtgcca ccatgtccag ctaattactg tatttttagt

3781
agagatgggg tttcgccatg ttggccaggg tggtctggaa ctcctaacct caagtgatcc

3841
gccctccttg gtatcccaaa gtactgtgat tacaggcatg agccaccatg cccagcctcc

3901
cacacgtgga tcttgaggtg tagtttgaaa ctggcttaag gaaaagtgaa gggagcttcc

3961
tagcctggac tccacatgaa tgttttgcct gcccctcatc cctttttaaa aaaattcatc

4021
ctcttatttt aatgtgtggg aaaatgtgcc aacataggtg gttatttgtt cttttataaa

4081
ctgagttcat accataatat tcccataagc atcttagaaa tctgttgtat agttggtgcc

4141
tagcagcatg gcattctcct ctgtccccta tccccaccat ctcgtttctg ccccaccccc

4201
aacaccctga ccaatttccc aaagaccctg aatcatgaaa acagaaatat cgttatttat

4261
tataatttgt gaaacaccta atatgttcca ggcactaggt atgctgacac gaataagatg

4321
catcctctgc ttccaaggaa ctcatagtcc aatggagaaa gagaaaacaa ttcaatgtga

4381
taagggctgt ggcaggggag tgcaaattac ttgctaaggg agtgcaaatg aggttcactc

4441
aaagcggtct taggggatct tgaatagctt cctggaagtt gaatgtcaaa gctgagtttc

4501
cctgatggct aagtctgagt ttgccaagtg atgggaagta gggtggggtg gggatggctt

4561
gaaaatagac tatttcagaa gctagtaatg aatgttgagc aatattgtga gctaaaattt

4621
ggctatggag ctttcaagat tgctcagatc aggccaggta gatgcccgaa gagaaggagg

4681
atggcctatg aacccagggt ggagcctcag cctgatcaag catgttctta atcacaaagg

4741
tggacgggag agagactagg atgggcbgtg tggttcctaa gttaaacaat gccaagtatt

4801
ctacactgtg ctctaagggc tgtgacatgg tgacaccctg tgactcctgg gggacaggaa

4861
ccatgcctca ttcatgtttg ttcagcaggt gcctagcaca gagacaggca cataatagat

4921
ggtatattta gtgaaaaaga ttgaattgca ttcctgataa tgaatcttct ttatatataa

4981
aaaatggtgg ttcatgctcc atgtctcccc agttttcata gacaagtatc ttataagaat

5041
tcattttgtt tataagcatg agacactatg ctaagtaaga atgttgccag ctatctcatt

5101
taatcctcat aacaatcctg ctaggtaggt ctattattat ttcattttca gtaggtgaaa

5161
aaatctatta aatcttgccc agggtcacgt ggctggtaag tggtacagct gggattttaa

5221
tccggtgtct attgtgtagt tccttacttt atgggtaaga tgcttttcta gaaacattat

5281
ctctataaag ttttctgtgt aaggtgaatt tctgggaggt taatctggct cagttacaca

5341
tccatttatc attcattcac ttaataaata tttataaact aattctgtag accaggtatc

5401
cagccatgtg cactcagtgg ttcattaaca ggcacaggtg ctgacttcat ggagctttgt

5461
aaaattattt tgaggggtag ggatgggaat taaataagta gataaataga aaaataatta

5521
tagattgcaa tatctattgt ggtggattaa atatactgca atagggatta atttgaaagg

5581
tggatcttta tttttatatt tttttgagac agggtcttgc tctgttgcgc aggctggagt

5641
gcagtggtga gatcacagct caccacagcc ttggcctcct gggcccaggt gatcctccca

5701
tctcagcctc gccagtagct ggaactacag gcatgtgcca ccatgcttgg ctaatttttg

5761
tattttttgt agagacaagg tttcaccatg ttgcccaggc tggtctggaa ctcctaggct

5821
caagttatct gcctgcctcg gcctcccaaa gtgctgggat tagaggtgtg agccattgtg

5881
cccagccagg aagggaggtc tattttagat ataatggtca aggaagaact tactgagaag

5941
gtgaaattta gtaaaagaca agagaatgag aaggagacag ccatgtgata agcagaaaaa

6001
aagagtgtac caggtaaagg tgcaaaggcc ctgaggccag aaaacttagc attttccagg

6061
gaggaagagg aagaattgta gtgtggatga gtgcagtggg ggagggtgag taaaccatga

6121
aataaactga ggcaggactg ggattaggat gaggtaaggg aggcactcac tctcaggatg

6181
cctctttaaa tattgtaccc taggaaactc atttgcctca ccctattcct ggccctgtgg

6241
ggatattgct gtgaattaaa gggagaatgg gtgtgtcagc ttgaaccaga tgatgcaggc

6301
tatgaagaga gctgcaagat aggaatatat tgtgcagcaa gaatcactga cacataatga

6361
tgagtgtgga tgaaaatcac tgatgcctcc aaggttgttg gcttgagcaa ccggatagat

6421
cattacatca tttatctaaa tggcaaagac aggctgagga gcaggtttgg gataggaaat

6481
caagtttcct tttggatatg ctaagtttga gacacagggt gagacatcta agtggagatg

6541
ccacctagag aagtgggagc tactgcaagt gtgaaggtta gaggagaggt ctaggctaga

6601
cataaaaatc aggaaagcat tgctgaagag gtgatattta caagagtggg aatgcctgtg

6661
attacctagg aagaaagggc aggtgtagaa gaaaagagag ccagagtact tagaagttag

6721
gaaggcaagg agaggggcag ccaagaacct gagaaagcct ggcgcaggaa gttgaagaca

6781
aagaacaacc aaaggaatgt gggatcagaa gccaagagag aaggtttaaa aaaaaaaaaa

6841
aaaaaaaaaa agcatagagg ggctgagagt gttgaatttg cctgaggggt ggggtatgat

6901
gaaggattac agactgcttt taagaagttt tgccatgaat cagagggaga taagagatga

6961
agacagagtg aagggagaat ttgtttttct taatatggga gatactagaa cgtatttgtg

7021
aaccgatagg aatgacctag tagaaagaaa gagatctgtg gtgcaagaag tacaagagaa

7081
ataactagaa gcaaagtagt aaaaaggggc aaacgtggag gggtttgaga atggaactag

7141
gagaactact ccttaaaggc aggagggata tttcttccat tttcaaagga agatagccca

7201
aatggtgcag atgcagacgg gtttgaaatt ttgatgaaaa gtaacttggg agcatctcat

7261
gcattctgtg ttttcgatta aatgcagaat atgtccctta actttgagtc tggtggagaa

7321
gggtttgggc agattgaggt aagtagggga ggtttgaata gttgtctcaa ggagaggaaa

7381
ggcacacccc ctgaggaaat gtaactgggt ccccaggcag tgttgagtgc ccatctagca

7441
cttgtggtca cacattttac atgaaattgg ttagcccaga tgtagatgcc ttcagtccag

7501
tttatctagc tgctcaaagg ctctcatgga taaggtagat gtttgaggtc agccaaattg

7561
gggttttgcc agacaagaaa aggaaggaaa gagagagtga aaaaagggag ttaagaatat

7621
ttgcaaaatt ccatggaatc tgtgtgggca agggtggaag tgaagacagg aaggtgtgga

7681
ggatagagag aaagtggatc ggttaattaa ttagaagcct cgtgagcaca aataaatgtt

7741
gcaataagga ttctgcagta gatgagctgg aaggtttgga ggctgtagct ggagagaggc

7801
tcaaaattca gattttggag gtggtggtgt ggtttccagt gatgacaatg tccatgccac

7861
aaccactggc tgagcagctg agtagtagaa caactccgag aagaccagct caggttactg

7921
ggaagccagg aagttgctaa ggatgatggg atctttgtga tttttgttat taaaacaaat

7981
tcccatcaga cagcaaaaga tcgatgcaac ccttgtagtg ctatttttat tcacaacttt

8041
aaggagtctg ctgtctgctt tctccttttg acttttatgt atttgtttgt ttaaacaaca

8101
gaaatttatt tctgcaacat gaaggtgcct gtagattcag tttctggtga cagcccgtca

8161
ccttgctgcg tcctcacatg gtggaaggct ttacctttag aagaaattta aatttaatat

8221
aaatttcaac tgtttattag cacctgcttt gccagtattt gtcaccatgc tataaatcat

8281
gactaccaac agagaaattc tatcatttaa atcaatggct cagatttctt ctaatttttt

8341
ttcttttttg agactctttc tcacacaggc tggagtgtag tggtatgacc ttggctcact

8401
gcaaccactg cctcctgggt tcaaactatc cttgtgcctc agcctcctca gtagctgaaa

8461
ttacaggcat gtaccaacac ccccagctaa tttgtgtatt tttagtagag acgagatttc

8521
accatgttgg ccgggctggt cttgaactcc tggcctcagt gatcttccca cctcagcctc

8581
ccgaaatgct aggattacaa tcatgagcca tcacacctag ccccagattt ctttacaaat

8641
tgtgtaattt taaaactgtt gtaccaagtt tctttataat aaagatgatt ccagtatatt

8701
tgagtagtag tggtccctaa atgggacact ctgtatgaaa actgaaaagt tccccttttc

8761
caggcatatt aagaactgca gagcccagtt tggggaaatg gaagtttgag aaggacttga

8821
aaaatgtcca tatgaaatag acaagttgtg ctttcatccc ctgctccttc ttttcttatc

8881
ttccttctgt ggagtcacct tcctatttta ttccatgctg ttgggactac tgactattgc

8941
aattcctgtt tgtaatttac atattaaaac aattgtacta atagatatat ttttctagaa

9001
tacaaactcc actagggcag agactttgtt ttaacagtgc ctgacacatg gtaggtgcat

9061
aatcaactgt tgttgaatga atgaatgctt attgtagaaa actagaaaat acatataagg

9121
aacatgaaaa aatacctcca ctacaaacta gaagtctcct ctgatcctac catacagata

9181
acccattgat atttcagtaa atatcttact aggcacataa atacttatct atataaaagt

9241
ataatgaaat gtctggaaat aataagcacc aaattcagga taattgttgc cttctgaggg

9301
tagagggagg aaagaggatg tgattgagga agagtatact gagagtttcc gctgcattgg

9361
cagtaattta tttcttaagc tagatgatgg atacatgaaa gtttattata ttattcattg

9421
tgtattgtgt ttcttgtata tgtaaattac ttcatatttt attcaaaata cctccagatt

9481
tttttttttt tttgagatgg agtcttgctc tgttgcccag gctggaatgc agtggcgcaa

9541
tctcggctca ctgaaacctc cgcctcctgg gttcaagcag ttctctgcct cagcctcctg

9601
agtagcbggg attacaggtg cctaccccca tgcctggcta atttttgtat ttttagtaga

9661
gacggggttt caccatcttg gccagggtgg tcttgagctc ctgacctcct gatccaccca

9721
cttcggcctc ccaaagtgct gggattacag gtgtgactca ccgcgcccgg tccctccggc

9781
tttttttaat gcgtacactc ccacaggctg gagtgggagt gtatttttta caaaagagga

9841
agcatacata cctatcagtt ttgaatcttg attttactca cttttttccc tcttacttca

9901
catctctcca cgttactgaa tgtacttctg agcatcacat caatttcatt tcatagaatt

9961
acgaagtatg aagcataact tagttaacca cttccctgct tggggacatt catctgataa

10021
gtaatattga gtgtgtgggg gccagcatat tcaggcbgtt gccattttta ataaactact

10081
ataaatgtaa ttccttatta atgactcaag agtgaaaagg cttgattttc tctcattgtg

10141
agtgagtgaa gggtgaggag gtaaaacgga gtaagatatg ctggctacct aagtatttaa

10201
ccaaggaaaa gaatgtcatt atcctcttct aaccctcatg taaactagaa tgttgatttc

10261
tctatagcca ggcattaatg ggtctggggg ctgctgccat tgcctagtgg aggagttggt

10321
caacttcatc agggtagagt tgtcttgtct gctgctgagt ataattatca tattttttct

10381
ttgggtctaa cttttcttcc ccaccaaaaa aggagaaagg gcagtgtaac aatgactgtg

10441
tccctcagaa cgcagagaaa tattgagctc agacacaact gcctctgtgc aaaactggtc

10501
tgagcctttg gagtgaattg accaaaactt ttttttttct tttttagaca taaggtcttg

10561
ctctgttgcc caggctggag tgcagtggca cgatcatagc ttgctgtaac ctcaaactcc

10621
tgggctcaaa caatcctcct gcctcagcct ccttaataac taggactaca ggcgtgaacc

10681
aatatgctgg gctcattcat tttattgtag agatggagtc ttgctatgtt ttccaggctg

10741
gtctcaaact cctgggctca actgatactc ctgcctatgg cttcccaaag cactgggatt

10801
ataggtgtag gacaccaggc ctgaccaagt ttttaatcaa catttgactt gattgttttt

10861
tcccactgat ctgattggtg gaagactgaa ttactgatca actgagtcca ttcatttgag

10921
caggtgatgt ttgtagatgc aatcattgtt ccaggtgatt tggatcctgt tctgcatcct

10981
agcatagcca gtctgtatgc aagataagga gaccaactca ggacaggctg atctgttgaa

11041
actgtaaatt gagagtatct gtgtaaaggc ccttctttct gcagtagaaa gacagatgct

11101
cctctacttc tcatgagtta catcctaata acccattgca agttgaacat attttaagtc

11161
aaaaatgcac ttaatacacc taacctatgg aacatcatcg cttaggctat cctacctgaa

11221
atgtgctcag aacacttaca ataacctaca gttgggcaaa ataatctaac gcaagcctat

11281
tttataataa agtattgaat atctcatgta gtttactgaa taatgtactg aaagtgaaaa

11341
acagaatggt tgtatggtta cttaaagtat ggtttctact gaatgcatat tgcttttgca

11401
tcatcataaa ggcaaagtca taagtggaac cattgtaagt tgaggacttt ctgcatactg

11461
taactttggt ttgtgaatgt aatcactttg catgtgcttt cagggatggc atatgcccta

11521
ctagctgcag ttcctgtcgg atatggtctc tactctgctt ttttccctat cctgacatac

11581
tttatctttg gaacatcaag acatatctca gttggtaatt ataagtatat tttacaatta

11641
tatttgctca tgtttaaagt gttttggcta tattaagtgc attatacctc tattaggttg

11701
gtgcaaaagt aattgcggtt ttcacaatta tacttttaat tgtgaaaacc gcaattactt

11761
ttgcaccaac ctaatatatc tgtgttaatg ttgtcaggga aatgggattt cagtgttttg

11821
cctgcttttt ctattcactg atgttaggta acttttttaa tgaagtggaa aaataaaaaa

11881
actgaaaatg acagcctact ttaacatttt agcatgtttt gctttttaaa aacgtgatca

11941
atttgactcc atttttggag tcataatgac agggaaaaaa tgacacaagg tctttgaacc

12001
taccatttta ctggattaac ttagaaatta ctaagtatgt tcatcaaata catgttcatg

12061
atttaattaa agagcatact tattttaaat cactaatatt agaagactgg caaaatctta

12121
ccaaaacaat ttagaagcta agcttggctt tctttcttgg tatggcttat aataagtttt

12181
cctgctattc ctaaaatttg aattctcgtt tgttagaatg tcctagtaaa tgagtgtttt

12241
aatgctattt tgtgactttg acatttatac tagagaaaat tttgctccta catccatctg

12301
ctggctagac atgtctacct cgatgatcct cttgaaataa atgcaaccat ctactttatc

12361
cccaacccat gtttttgtcc ttagttgtat ttccttagaa ggagatcaga aagaggtttt

12421
gattgaaaga acttccacac cttggagaat caatcagtgt tgagtgcttg actagatgag

12481
gaacatggaa gcbggttttt ctctttggta ttctatacat tgagatattc caggtgactg

12541
gggttgggtt ttgagacctc aaaaccataa agccttccat gatgagaggg tagaatcatc

12601
atcatcgtca tggataaaaa taacagtagt gaacggagca attgctgaaa aaaaaatatt

12661
ttttaaaata taaaatctta cagattgaca tttgatatga aaaaatgttt tgtcttacaa

12721
aaagagaaag aaacttcata ctccctttgc tgttttttta atcctaactt cgaccctgtg

12781
atattgatca aggtactcag atccacagag atcaggacat tggacactct aggaaattaa

12841
tgagattata tgaaataaaa gttgagcgga acaagtaaac actcaatgta tgtgctacct

12901
ttgccagaaa acctttcctg acaactctca tccctgtccc caccacccat acacatgagg

12961
atcacacaca gacaggttag acgacctttt gatatactca cgaagcatcc tgaatgttgt

13021
attctaataa ctacctacgt gtctctctcg cctatttcta ggtcatgaat gcctcgagat

13081
atctgcgttt ttagcttctt tttgttgttg ttgagacaga atctggctct gtcacctagg

13141
ctggagtgcg gtggcgtgat ctcagctcac tgcagcctcc acctccccag ctcaagcaat

13201
ccccccacct cagcctcccg agtagcbggg accataggca cgcaccacca cacccagcta

13261
atttttgtct tattttggta gagatggggt tttactatgt tgcttaggct ggtctggaac

13321
tcctgggctc aagcgatctt cccacctcag tctcccaaag tgctgcggtt acagatgtga

13381
gccactgggt ccggctcagc ttctttcgtg aacaaacaat attttcctag tcacagctaa

13441
atcttttata cattttttaa accctatgca gacacattga acatttgtga ttaataactg

13501
attaattgtt agagactttt tttccccagg accttttcca gtggtgagtt taatggtggg

13561
atctgttgtt ctgagcatgg cccccgacga acactttctc gtatccagca gcaatggaac

13621
tgtattaaat actactatga tagacactgc agctagagat acagctagag tcctgattgc

13681
cagtgccctg actctgctgg ttggaattat acaggtaatg aacttacaag taaaatatag

13741
atggatgtaa tttttatttg aaattaactt taaagcatat agacttaaag attctactaa

13801
aaacaaaaca aagtaatttc ctggaaccca aaattatttt ctaaattacg ttgttttagg

13861
tcaggtgcta aaatagtaag caagacccca cttattaagg ctcacttatc atcaaagtca

13921
gagacagaaa aaagcacaga agaacatgtg tgattcaatt gaggatgaga gaagggaaat

13981
atacgggaat ccataaagga gaaaaagtgt tctggtgagc ggagacacag gaccgaaagc

14041
cacataaata agctctgggt ttttgctttt ctaagtacat gtatagaaat acttcaaggt

14101
ttttattaca cttagttttc aaattttaga gtggtggagg aaggggagtg atagggtatt

14161
aagaaattca tatttttttc taccagtatt tttgtgctat aggcaggcta ctagtgtttt

14221
cattggtatt aagcttgatg taatatttcc agagagtagg tttctatctc aggcaaacat

14281
ttaatttttc tttccttttc cttatcgtag ttgatatttg gtggcttgca gattggattc

14341
atagtgaggt acttggcaga tcctttggtt ggtggcttca caacagctgc tgccttccaa

14401
gtgcbggtct cacagctaaa gattgtcctc aatgtttcaa ccaaaaacta caatggagtt

14461
ctctctatta tctatgtaag tgttgcttct tgctccaggg atgggtcact gttcattcca

14521
gaaacaattg tattcattct ctgagtctgg gccaggcgtg gtggctcaca cctgtaatcc

14581
cagcactttg gaaggccgag gtgggcagat tgcttgagcc caggagtttg agacgtgaga

14641
cctcatctct taaaaaaaaa aaaaaaaaaa aagaaagaaa gaaaagaaaa gaaaaagaaa

14701
gaaaaaatcc aaaaatccga aaatttgctg ggtgtggtgg tgcacacttg tagtctcagc

14761
tacttgggag gctgaggtgg gaagatctcc tgagccctgg aggttgaggc tgcagtgagc

14821
tgtgatcgcc ccactgcact ccaccctggg tgacagagca agaacctgtt tcaagcaaaa

14881
acaaaatcaa aacaaaacaa aacttgagtc tgggagcacc cacatttctt tctttctttc

14941
tttttttttt tttttttgag acagagtctt actctgtcac ccaggctgga gtgcagtggc

15001
atgatattgg ctcaccacaa cctccacctc ccgggttcaa gcgattctcc tgcctcagcc

15061
tcctgagtag ctgggattac aggcgcccgc caccacaccc agctaatttt tgtatattta

15121
gtagagacag ggtttcacca tttgggccag gcbggtcttg aactcctgac cttgtgatcc

15181
acccacatcg gcctcccaaa gtgctgggat tacaggcgtg agccaccgcg cccggcctgg

15241
gagcacccac atttctctat gcatactttg ggagccattg aaaacatttg gttgcttctg

15301
tcagaaatac tattgtactt aaaaacatta atgaaaacaa agtggtctaa tgaagtaaag

15361
gctgctctgg aatgtaacag acttgatttc tagcctcagc tttgtctcta acaggtaagt

15421
gaccctggat acatcatgta gggtgctaat tgaaagctca gttttagaac tggatggacc

15481
ttgattcata ttctggctct actgtctact agccatgtga gccaatcacc atgcctcagt

15541
ttccttctct gcaaaattgg gttagtaata gtatatgcct cattggattg ttaaataaga

15601
atagataagc acttggccca ggggcbggta cataacaagt actctaaata aaggagttat

15661
tttgaaatga ttatttcaag ccatcttttc ttttttattg gtgaaatgaa atgattggag

15721
atgtatctct aaaagctttt tctaaccata agagtccgta aaatgcataa tgtaaatgtc

15781
tcaacaatta taaatgaaaa ggaacattag attcagagat gattcaccat gcaaaagaaa

15841
tgcaaaagca ggatgtagat cacactaatt agatttgaaa aaggttttgg atctaaaaat

15901
gtgttctaca taaagcatgt tattgatgct tgaaaaatgg tgataatagt aacatgatgt

15961
catcctagct tggggggaat gataccatac aaaaataacg tgtcaacatt aagaatggag

16021
tttgagtctt taaagaccca cctattagct tctaaaacaa tgtaaggcca tgtacacata

16081
tctaagaatt ggtgagtatg tcaataattg ctcaatttta taacggtgcc ataatcccat

16141
actattacac tccatccatt caacaaatat taccaagtgc ttactacagg ccaggtacta

16201
tgctaagcag tgagaataga cagaggaggc agaataacat agtgaataag atcatgaggc

16261
caggtgtggt ggctcatgcc tgtaatccca gcagtttggg agactgacac aggtggatca

16321
cttgatccca tgagttcaag atcagcttgg gcaacatgac aaaaccttgt ccctactaat

16381
aatacaaaaa taattagaca tgcattgtgg cacgcacctg tagtcccagc tacttgggag

16441
gctgaggtga gaggatcacc tgagctcagg aagttgaggc tgcagtgagc cgagatcatg

16501
ccactgcctt ccagcctggg tgatgggagt gagaccctgt ctcaaacaac aataacagca

16561
acaacaaaca aaaaaccaaa aacaaacaaa aaagatcatg gactttgaac ttcaacagac

16621
ttgagttggc atcttggttc tccacccact acccatgatg tttatactca acttccctaa

16681
gcctcagtgt cctcaattgt aaaatgggag tagtaatagt agctacctct tagagcagtg

16741
aggattgaaa aagaaaatac gtgtaaggca cttagcacaa tatctgtcac atagtaagaa

16801
ttgagtttat tattattatt atcacagatg aatagacctc atgaagctcg ccgttcattt

16861
cctcgggacc cagcctatta ggaaacatta gcaaaagttt ttgattcagc attatatggg

16921
tcattcttga tatgtttttt cctgtcaaat cctcagtttt ctattaaaaa agaatttttt

16981
tttttttttg agacagggtc ttgccccatt gcctgggctg gagtacagta gcacagtcat

17041
agctcactgc gacctccatc tccctgtgtc aagcgattct tccccctcag cctcatgagt

17101
agctggaact acaggtgtgc accaccacac ctggctaatt ttctttttct ttgttgaatt

17161
ttagtagagg caatgtcttg ctatgttgcc caggttagtc tcgaactcct gagttcaagt

17221
gatcctctca ctttggcctc ccaaagttct gggattaaag gagtgagcca ccatgtccag

17281
cccatatttt aaaattaaaa ttaaaatttt aagattttat tttggtagag acaggggttt

17341
tgcaatgtcg cccaggctgg tcttgaaccc ctggcctcaa gcagtcatct tactgcatgc

17401
ctcctaatgt gttgggatta taggtgtggg ccactgcacc tggccaatcc ttagttcttt

17461
ttgagacctc tgactgcctt attttgacag gctctgtaac ttttgcagct cctggcacat

17521
cttgctttta cttactttta cattttctcc atcaaatgtt cactcattta ttccttcatt

17581
ctcattcatt cagtttatct actcaataaa cacatattga atacttacca tgtgccaggc

17641
actgttcact ccctatacaa acccagtgac tcattaacct accaagacat ctcttactga

17701
gtattctcac ctcactgggc aaacattgct aggccttcat ctacacagat cgcaggaggt

17761
ccaaactaat tgttgacctg ggtccatggc catttcagga cccctgcaga acaggagaaa

17821
tagttcttct ggtctcatag gattatgttt aagaagaaac tttctgcaaa tgatttcact

17881
ttgacaggga caaaagtgag caggaaacac tagaccaagg tcaaaaatag tttttaaacc

17941
aagtgcagtc attatgtaac ttacttcctg ttgaatattt ttcttgaaat ctcagtttag

18001
catacagcat agaattttgc aagaaactcc tcacaggcca cccaagttgg aaaaggtatt

18061
tcagtcatcc ctatatggtg gtgaatataa gtttgctctt ctgaaaaaaa aaaaaaatca

18121
gcaggtctga aaacgattgc atagggttaa atgagccgct tagtctctga acagagaatt

18181
ttgcttatga cattaccatt gcaattatac atgaaagaat ccttcaataa atgcagagta

18241
gtagaggatt ctcccagaaa agactgtaag attgttgtaa aatactttac ctggagtgtt

18301
aacttatctt tgttctaagg ttgcactttg gtttgtcctg ccctctcccc caaaaaggtg

18361
ctgacaacta gaagtaacaa atgcaaagaa ataggggaga aaatattaga agaaaaagaa

18421
atcagttaat ttacaaatgt cagagatact ggatgtagga ggcagaaggg agaatgacag

18481
ggtattggca gcaatttaga attagtcaat acccttgatg ctaccatgta gctactcagt

18541
tatctaagta aatcccagtc cacttagggg ttgatttccc accactcaat ttgaatggtt

18601
tgtctcagta gacaagggtg agagctttga aagccaccac taagcttgat tagatttgtt

18661
actttgtacc tatttcagta tgtaaaattt atacattgta ttaaagtaac actttaagga

18721
ttgatctata catgtataca caaaagatat ggaaggaaat gcctgacagc aaaaggtggt

18781
cgtgaagcat ttgtgatatt cgtagagata aaataaacaa aaataaattc agttccaata

18841
gtaaactgat caattttctc atacacatta ttgggcataa ttttttctta cggtttcata

18901
aacacaggta atcctgggca agaacaaaga aattatctaa atgaaattgt cctaaaattt

18961
tccaaacaca gcaggaaata taataaaata ttatctatta ccaaaaagtt cattatcata

19021
atttgaatta tttggaatac taagctaaaa tacagaatta tatgtgtatc catactatta

19081
acatacttta tggtatttta acagtaaact aaattagaag tactgttcag tgtttttgta

19141
gagtctaatt tctatgtcgt taaatataat cttatattat tatataatat aatcttatat

19201
tattatataa tcttatatta ttatattata taatcttata ttatataatc ttatcttata

19261
taatcttata ttatatgctc ttatataata taatcttatt atataatctt atcttatata

19321
atataatctt attatataat ataatcttat tatataatat aatcttatct tattatataa

19381
tataatctta ttatataata taatcttatc ttattatata atataatctt attatataat

19441
atattcttat cttattatat aatcttatct tattatataa tataatctta tcttattata

19501
taatataatc ttatcttatt atataatata atcttatctt attatataat ataatcttat

19561
cttattatat aatataatct tataatataa tcttaactta ttatataata taatcttatt

19621
atataatctt atcttattat ataatataat cttatcttat tatataatat aatcttatat

19681
tattatataa tcttatctta ttatataatg ttatattatt atataatctt atcttattat

19741
ataatgttat attattatat aatcttatct tattatataa tcttatatta ttatataagt

19801
ataatctttt attatattat tacataatat ataagtataa tcttatatta ttatataata

19861
ttattattat acaataataa tgtaaactga ctattgcagt ttacatggtg agttttattt

19921
ctgcacagat taaactttct atcatagagc tcttcttaaa agattctgaa tgactactca

19981
atatgtaggc aacttattta catactcaga taccttgcat gatgcaattc tgtaatataa

20041
actgattttg gtttttgaac ctcgtgttac atttctaatc caccagacat actttttatt

20101
caaaggtcta attgattctc atggattaaa ctggaatcct gtagtgatta tttttgtaag

20161
gtaaaaatgt ttgtgtgatt gggataatga ttccaaatgt tttgtttttc aagttttaat

20221
ttttgcatct tgagttgaaa agtacacctt taatgaatag acaattcatc aaaatgttat

20281
acctagctcc tgaattaatt agggtcattc atcagaaaac tgattatgta aaggaccaaa

20341
cagcaatgat aaccttcaag cctctgggat aggtagggct gtttgctcct gtgctaaatg

20401
ccctaagttc ttgttatcgt gtctgcbggt ggtagttatc ccattttctt tttcactctg

20461
ctgtccctgg catcatcttg tttctgtcag tgtaaatgcc tttagcaatt ttcagtgact

20521
ctgaaaacca gacaaagtga atttgttagt actggatttc aagaaagagc aaaagtaccc

20581
tctgagtgaa agttcaagag tcttcctaca agttaaatgc ctgaactcta gtccaagtgt

20641
ttggtgggag gtattttgca tgcataatag cttctccccc atttccttac tcttcttgaa

20701
tgtgttccag agagctgagg ttgctggcaa agtgactcct agattactta aggttcatta

20761
agtacttaaa gttcattaag ctcatacata attgtcacca gattatcatt ataattattt

20821
taaaagtagt ttatctgtga aaataagtaa aatacatttt ataaatgtta taaactataa

20881
gatgctccat tattttatct tcctataaaa tatgtctata aaaaagctca tttaaagaaa

20941
agttaccttc actgtgagat tgtctcaaag aaatgtctca aagatacctt cttaaatcct

21001
gccttctaca ggactgaagt taatataaca aagatattag tgttcttcct tgggattctt

21061
ccttgctaat ttccttgaaa acacccttga ttcccagaag tctcctattt acaaaacaaa

21121
actagttttt cttgaattga ttcatctgtc tacttaaaga ttttttttgg ccagttgtgg

21181
tagctcatgc ctgtaacccc aacactttga gaggttgggc aggaggattt cttgaggcca

21241
ggagttcaag accagtctgg gcaacaaagt gagacaccat cccctgcccc cacctcctcc

21301
cgccccaatc tctacaaaaa ataaaatagc ctatttattg tactctctac aataaataaa

21361
ataaatatag atgcctgcct gtagctccag ctactctgga gggtgatgtg gaaggattgc

21421
ttgagctcag gagttcgagg ccactgtact ccagcctggg caagagagct aaaaaaaaaa

21481
aaaaaaaaaa aaaaaatttt ttttatgtta tcttagttca agtttgagaa ataaaattaa

21541
gtaccaaatt tattcccaaa aatgtatgct tgtcaggaga tatacctaat gttaaatgac

21601
gagttaatgg gtgcagtaca ccaacatggc acacgtatac atatgtaaca aacctgcacg

21661
ttgtgcacat gtaccctaaa acttaaagta taatttaaaa acaaaaaaca gaaaaaaact

21721
acagattcaa ttcagcttta ggaattaaaa aaaagatttg atgtaattat atcattataa

21781
aatcaaattt tttaaataaa acatgaaatt gttttaattt aaaaaaaagt atgcttggcc

21841
tatatgtcaa ttcaatagct tttctttgcc agaaagaatg aagtcagtct acctgtatcc

21901
acatatgaag tattttagga ttttttgtaa ttttttgtta ttatctatat cattcaggtt

21961
taggaaagaa ctttacctaa aatactggct aattgtgccc caaaaaaaag aaagctagaa

22021
agaaagaaca cacacacaca cacatacaca catatacaca cacaaaaaaa acaaccaact

22081
gatcaactgg gagtttcagg tttatcagcc tttagtctca atgctgtatc actgtagtaa

22141
aaatcaggct acttgatagc acctagaaac ccattttaaa atataaactt gtaaagcatt

22201
tctgtaagta aaagttagta tgtttataat gacatttttt cttttaagac atctttatta

22261
ttatcataaa aaatacagag aagcaaaaat aagaatgtag aaatcaccca gtttttcctt

22321
tccaagtaaa caatcataaa aaacttggtg tatatatata ttgcagcaat tgtatgtatg

22381
taatggtctc tgtatcaacc aacacatttt tatcatttta ctgaaacttt tgagtgttgt

22441
ttgatgctga tatcatggtt tttcatgtgg gaagattcat atgagaattg attgtgtgtg

22501
tgtgcgtgtg tgtgtgctcg tgtgcgtgta gcagcaggaa gtatataaaa ttattttctt

22561
tttatagacg ctggttgaga tttttcaaaa tattggtgat accaatcttg ctgatttcac

22621
tgctggattg ctcaccattg tcgtctgtat ggcagttaag gaattaaatg atcggtttag

22681
acacaaaatc ccagtcccta ttcctataga agtaattgtg gtaagtagaa tatgtagtta

22741
gaaagttcag cattatttgg ttgacaaaca aggaattatt aaaaccaatg gagtttttaa

22801
catcttttgt tttatttcag acgataattg ctactgccat ttcatatgga gccaacctgg

22861
aaaaaaatta caatgctggc attgttaaat ccatcccaag ggggtgagtg tggtgttcct

22921
cttagtacta atacattaag tcagtaagtc agtctttttt atttaaataa aaccttttat

22981
tacaagcttc atttcactga tactccttca atagtcctat ttgtgtgtga tctggaagaa

23041
acaaccataa gacaaacagt atgtgtgtag ataaacgtca agccatttgt ttaaaagcag

23101
cccgtatatg ctcttttttc ttcattttct taaaacatgg cagaacatgt acggttaaca

23161
ccagagtcct gatttaaact tatacataac attataatat aatataaata gaatcatttc

23221
tcagtaacat ctattgcact gtgaacaatc tgcttaagga atcagggacg tctggcctaa

23281
attctctatc atttagttta atcaattttg gataataatt atatcctcgt acccataagt

23341
aaaatgcatt atcttcaagg gaagttttag aaacatttgg tagtttggtg aattagaaga

23401
gtaaaagatc aaggtccttc attcatctct gtcaccttcc agttttgtga cctgaggaga

23461
ttctcctata taagacaagg ataatgaaaa cagccgaagc ctcaactcaa gcttattatg

23521
aaacaccagt gagatctctc atgaaatgaa gagtagtcaa gacaccctac accataattt

23581
tctcatatgg ggttacaaag gaggcctaga cgtttattat atttgtaaca tacactcata

23641
acatttaaga ctagacttgc tgttaatcaa gaagtactag ttttccctaa gactggaaga

23701
gtttggtacc ggtgtttcta ccaggaaagg gagtggaggg gagggaaggg cacggagcca

23761
ctgtttggta ccagtgtttg ttttccatgc tcttaataga aacttcctca ggcaagctta

23821
ttcccagagc ttattctaca gggaactgct gtattcccat ttgatgaatc ttataatttc

23881
ctctaatatc tgttccaaac tatttgaaaa agcacagctg gctacatggg acttaatttg

23941
catgctatcc attacagtgt ttctcaaact tacccttttg taagaatcac atgggatcct

24001
ttttcacaca gattcctggt tcccacccca aacctattga atcaggcttt ccagaggtgg

24061
ggctcaggaa ttaatatttt tcaaaagtgc ctcaagtgat tcttgccctc aaggaaactg

24121
gagaaactct ttaagagagg atcaacaaat ctaatctaac aactagataa tttcattagt

24181
tagaaacaat tacagaaaaa gatactttac agatctcttt tgtcaggctt cctaggatgt

24241
atcaagttat aggtggtcca cagagcaggc cctgtcccat ccatccgtgt tccattagtt

24301
ggtttaggga actcatttct tctgccctaa attatccctc caggtcctct gcagagcttt

24361
cctgtgctct cctcctgaga acagatttct agcctctcgc ccttgagttt aatgaagctg

24421
aatcctttga cagaccacct ggtcagcttg gtcagctaat ttaacctgcc tggccccagg

24481
gactttaagc tactccatga gggcagtgac cccattggtg ttgttcagct ctgtcccaga

24541
gcacagagct catctcacag taagctctca gaaaacactt gttgaaggaa taaaataccc

24601
aagcctatgt cattataaac aagccacaac aaaggccttg gttatctgat ctcacttggt

24661
agcacagaag caattctgat gatattaaca aacctgaaaa agaaagggag tggagagatt

24721
ggaaaaaagc aagcagagtt ttaaagtggc cctgaggtga gcacagtgaa aggaagaggg

24781
acagagagat tgtgatatgc ccccttttga tctcctccct gcttcaatcc tccattaagg

24841
ctgctgctcg tagttccctt tatcctattg agggtccata agttaggatc actcctaacc

24901
taggaccata cgttaggacc ataagttagt ccccaataac aatgccccat tggacagcca

24961
aaaacagtgg ctccatgccc ttccctctac tccctttcct ggtagaaaca tacaactttt

25021
ccttgtccag tcaacaccta agcgccccac taggattcac tcattctccc atcctgggtg

25081
ctttcttaac cagcagacac tatgagggcc agtcatgtgc ctctcttctc atgcaactgg

25141
tccttatctg caactcgtaa tctgcccagt tcctcactca tcctgcccag gcttctcttt

25201
tacctcttct gttatagtgg tgtgtgtgtg tctgtgtgta tgtgtgtgtg tgtgctcacg

25261
cacgtgtatg tgtaaaccca taacaagatt gacagctctg tcctctaaat tttaatccct

25321
attcactctc ttgcctcctg tccttgccag ttccagaggt ccccttgttg tcatgtttgt

25381
tactctcttt tttcttttct tttctttaac agagtctcac tctgtcaccc agcctggaat

25441
gcagtggcat gatctctgtg gtgtgtgtgt gtgggtgtgt gtgtgtgtgt ataaacccat

25501
aacaagattg acggctctgt cctctaaatt ttaatcccta ttcactgtct tgcctcctgt

25561
cttcgtcagt tccagaggtc ctcttgttgt catgtttgtt actctttctt tcattctctt

25621
tctttcttcc cttccttccc tcccttccct ccctttccta ccttccctcc cttccctccc

25681
ttccctccct ttcctacctg cactcccttt cctccccttc ctaccttccc tccctttcct

25741
ccccttcctt ccttccttcc tctctctctt ttttctttct ttctttcttt ctttctttct

25801
ttctttcttt ctttctttct tttctttctt tccttctttc tttctttttc ttttcctttc

25861
tttccttttc tgaaacagaa cctcactctg tcacccagca tggaatgcag tggcatgatc

25921
tcggctcact gcaacctctg cctcccaggt tcaagcaatt ctcctgcctc agcctcctga

25981
gtagcbggga caacaggcac acactgccat gcctggctaa tttttagtag agacggggtt

26041
tcaccatgtt ggccaggctg gcctcaaact cctgacctca ggcgatctgc ctgcctcagc

26101
ctcccaaagt gcbgggatta caggcactgt tatagacccc ttttgtcagg tttcctagga

26161
tgtatcaagt tataggtggc ccgcagaaca tgccctgtcc catcaatctg ggttccattc

26221
attggtttgg ggaactcagg cctactgttg tttttaaagt atgtgctttg cagttgtact

26281
tgaaagtgtg gcacaggggc aaagccaaca aaaccacagg gtttttttcc tggctgcttt

26341
ctgagggcta ctcttctcct ctagctggag tggtggtgca tttgccaagt gttcagaccc

26401
agtctgaagt actctggtat tctgtttggt attctgttta tgacgctggc ctgtcgtttg

26461
tggaattttg ggcccttcag ggttcacttc tcccggtctt catcttttca gataagtgtg

26521
tgttcacatg ctcactccct tgggctcttc atagtgttgt cttatgatca ggcctgacat

26581
gcttggctgg ggccaaacag gcccactgag caaaaaattt ggagagttat atccacagaa

26641
ggagggcaag ggcaagggca aggacaaaag gcttacttac aggtcattag aagatatcca

26701
gacgggactt caattggttt ggggcaaata attggcacac ttagggttca gcaagacagc

26761
agacatgagt ggcaggagta tgacagactt agattctccc aatatatacc aagaacctac

26821
tatatgtgta gacactaatt acttacttac acaagtgatt cctcattgaa tcatatgaga

26881
agaatatata gtccccattt gacagctgag gaaactggga tgtggtgggt ttaaataaca

26941
tgcctaaagt catttgagag tgattctggt cctttgactt aagtctttgc actttacact

27001
ttgcacacct ggataatcaa ggatcaggtc atatttggag aactaggcag ccaggcaggc

27061
aaagtgcatt aggctgctat caaaactaag ctgtatgtga aactggaaag ttatcctgac

27121
aagtccgagt gacctgaagt agggttgact gggtctcagg agcaagtcag gagcctgttt

27181
tgagaagtgt ggtcccaagt cacatcccaa ctagcaggtg atgtcatgct gagtcgccca

27241
actgttggat cagggtttcc aacatcctgt ctgtctacag atggggttca ttccacagtc

27301
tcattgbggg gtaggatggg atataaggag aaaaggagtc tgaaaattaa cctcactggt

27361
agggagagta aggctacaag ggcagagaac cagacagatc ttgttaggta ggaaatcgtc

27421
taatatctaa catttagacc tggacccact aactgacatc aagcaaatca cttcacgttt

27481
ccaggtctaa gttcctttat caacaagaca agacaagagt ggtggattca acaataccta

27541
ggatgctttc tctatggttt tctctaagaa ccttatttct attttatttt taccactgtt

27601
ctctaattat aggggaaaat gtagtttcct tattaaagaa actttaggca taagtgatgt

27661
aggtcgggga gacctttcat ggcbgggggc ctctggaatt ataccatatg gatagtcatc

27721
aagatatagg tccatctccc aaattttcat atttgagaga acctcgtggt ataatgtgta

27781
ggttaatttt tttatatggt ttgtagggta gctctggttt tgtcaaacag tagtcattgg

27841
accccacaat cactgagata ttttagtcac tatggagcgt tgtgataatt acattaattt

27901
aatctttttt gccttaagaa gattttaaat gtcctggctc tcaaaggatt ttccactgag

27961
ctcttttagc ttcatacatt ctttgtctct ttaacagagc tgatacctct tcaaacacag

28021
taaatctcat attatggcta gaatctcttt taaattcaaa gaactttaag atggaattgt

28081
ggaaggagaa acactaacat gtgaaatggc atggatgggg ctgtatgata ttaaagaatc

28141
agtaacagca gatttattca tgtgagagat agagaagagt cagcatggct aggctcaaaa

28201
atagaggaca aagaaatcag ccagtaagat aacaccaact tctgattaaa cattataaaa

28261
gctgctacta tcatgtatgt atttcgtgtg ctttttgttc ttttggatca agtactttca

28321
tgtctaatat gtgactgagc agatatagca tttgatgaga tggggaaaaa ggatggtggt

28381
caaatcttca cagcattttt cacttaaaaa ctcactaggt ttttgcctcc tgaacttcca

28441
cctgtgagct tgttctcgga gatgctggct gcatcatttt ccatcgctgt ggtggcttat

28501
gctattgcag tgtcagtagg aaaagtatat gccaccaagt atgattacac catcgatggg

28561
aaccaggtat gggtgccctt ttgctgaact ggttttatag ggctggaaac aggaaaaaaa

28621
cataaatgga aaagattttg gtgtcagcta aagaaggggt tggattcttt caccagacct

28681
tattgggttg gttttcctct tgtgtttgct aattagaaat tattttggaa tagacacact

28741
gcatcacttt gcttttttaa gaaataagtt gaaataacac taattttaaa agagctaatt

28801
cagtcaggtc ataaataaca ttcaaagtga acatattagg tcagaaagag aattcttcat

28861
gtaacccagt acctcttggc aattattttt aacggcagtt ataatgtgac aaaacagtgc

28921
aacaaacatt aataatagtt gtgaccactt taaattgagg tggttcactg tgcagttaat

28981
atatacaggc aatttttgta ggcatgtgat acattgccag gtaagctgat ttcacactgc

29041
ttgcaaattt gcaagttctg tatctatatg tttctgaaaa tacagtatag caataacagt

29101
agttaaatgg ttagtaatca agcagaataa cagcactgct agtcataata tgcttcatag

29161
tgaatattca accacagaaa aacactttat gtgagagctg cagacattcc attcactagg

29221
cagtgaaaaa gcttagcaaa tgatcaggtg ctatttcttg tcaactttaa aaattatcga

29281
gagcaatgag acctctctca gatggtatgg cgtccaaact cctgatgtcg tacaaggacc

29341
ccaagtacct atcacggtaa aaattaaatt ggaccaccac gcagagtagg catgggagtt

29401
ttcattctta atgtacttcc tgaaatactc agcgaaggtc ttgcaaagat tcaatttgta

29461
ggatcgttgt catccagtct cttccttagg aattcattgc ctttgggatc agcaacatct

29521
tctcaggatt cttctcttgt tttgtggcca ccactgctct ttcccgcacg gccgtccagg

29581
agagcactgg aggaaagaca caggtaggaa caacagcctt atgatatcca tctcagagaa

29641
caagtcgagg aatggcaaca gaggaaggct cgcaccgagc ttagcaggac aatttgcctt

29701
tcagacttgt acttcctaat ctgattcacc tcaggcctat tcctcttgtt ccactccctc

29761
acctgaaatc tcttaaaaaa caacatgtat ggttttctga tacagtgatt ctcaaatcta

29821
tttgtcagtg cttacctgtc atgtagctac acttacctgc tgtggtcaat aacaactgac

29881
aaggaatcag taatgaagga tgctgatttt tgttaatttg ttacctgggg agacagatgg

29941
cctggtaaaa gcgcttcctg gctttaggag ctattctatt ttcaggaaag tgaaaagctc

30001
tattcacatt tcctttagaa ggatcaggaa cttcctccag gggcgtttgg tcccacagaa

30061
caacagtttg ctagccaaga atatttttgt tgtaacattt ttggcatttc ttcctgagta

30121
agatttatgt tgttgaagtt ctgcatgtgg gtttaatctt atcttttaaa tgtggtttgc

30181
agttgttgcc tttacaaggt ggccaaaaag ccagcatcct agttaatctc tggataatcc

30241
ctccttcagt gttcagaaag ctcaggagcc atactcaaag gccactcttt ccagcaggac

30301
acagtcgaag agaccacacc aagcagatgg gcacaagaga cagactcagg aattttgctt

30361
ctgtctctta tgccttgagg tccttatctt cccaacacag aaagaactat tatttaggag

30421
taagaagtgc attgagactc caaagaacaa caaacccaaa ctacatagtg caatacacac

30481
acacacacac acacacacac acacacacat gcacacacac atgcacagtc ttcacagtct

30541
tcaaatgggt tttactaagg cggggacact taaaaaataa atataagtcg ggcacagtgg

30601
ctcatgcttg taatcccagc actttgggag gctgaggtgg gcggatcaat tgaggtcagg

30661
agttcgagac taacatggcc aacatggtga aaccccttct ctactaaaaa tgcaaaaatt

30721
agccaggtgt ggtggtagat gcctgtaatc ccagctactt gggaggctga ggcaggagaa

30781
tcacttgaac ctgggaggtg gaggttgcag tgagccaata tcgtgccact acattccagc

30841
ctgggcgaca agagctagac tctgtgtcaa atatatatat acacacacac acacacacac

30901
acacacacac aaacatatat atatatatat attctcatat atatatacga gaataactga

30961
aaaaactaat gactccaaca gtgacttgcc cagggagggc tttaattgtc cccaatatgc

31021
atgtgatgct cctttcctat ttataatgga tcttgtgaca gacttggaag aattggcctc

31081
ttccagtttt ttggctgctt ttcaacaaaa aattttattt tcagaatttt tcttaatttt

31141
ttattttttt tgcaaatatt tccagctctg agggagcagg taaaataata cagctcatat

31201
ccggaggcat agccagagat ctgtggtcaa ggggaagagg tcagagccaa tttccaaagc

31261
tgtgcacatt tcaggctgca gcbgtcagca gcaggaactt ctgctgcttt catttgagac

31321
ggagcactga caagctctcc agagcacatg gtcttcagcg ggtgcaggca aatctcaaac

31381
tgctgatgtc cattctcctg atgttacctc caggctcaaa tgaggcatgg gctggctgtc

31441
ccagtaagta tgcccatgta aagtgacctc cttggcacag ggtttggggg ataatggtgc

31501
tctggtaagc taataccccc tgccacatac tggcatgtat tatatttagg aatgaaggat

31561
gccaggattt cagcattaaa gaatgaaacg agtaaagaaa tggcttcatg tttaattatt

31621
gaaatgtata ctaaattctg gggttaaaag tctaagtgcc tgaactgaaa tccagggact

31681
gatggacaaa taaactggca gggcttctct tgtgtggctt ctcgtgtttt ctcttatgtt

31741
ggaacttcag tttcagcatc tacaaaatgg aaatgataat tgcatccatt tcacagggat

31801
attgtgagga ttaggcaaga aaatgtaaag ccttagcaca tacttgtaaa tgctcattgt

31861
ttcactcctt taggcaagaa tagcatctta gcatctatga tacatatatt gtgcctggca

31921
cataagaagc acctggcata tatttgctga atgaatgaat ggaagaatga gtattggtgg

31981
acacgaactg tttttagcac atctacagat tgtagaagaa ttaaacattg gaaccttttc

32041
tttccctcac ccccatctga cttccactga ctcacagaaa agtaattctg attacaaacc

32101
actctttagc tctgattacc ccctccctta acagaataat tttttagtaa ctgaatctgg

32161
ttgtagatat aaagtctaca gagtttctca caaacaagcc ttatcaagta agtagaaata

32221
attgatcact caccaatttt aatatagtgg ccaaaatgag ccttggcctc ccataattgg

32281
agactcatta tgacatataa ttggcaagta ggtggccact ctcctggcat gagtttggca

32341
gctgactgtg gtccttgtcc ccaaatctcc atatctttct ccagttcaca gagctcccca

32401
tccacagtga gatgcaagtg gctcggtaaa tactggttga gtaattgcat gcaaggaagg

32461
aagggaggga taagggaagg aaagaaagaa gaaaatggaa ggaaggacaa gggagaggaa

32521
gggaagggat atgaaggaaa gcgaagagaa gggagggaag taggatatca gcttctctgc

32581
ttagtcagga gaagggaaag agcaccaggg tactgggaat ctaggatggg gataggaaga

32641
gcatagaaaa gccagccaga catacaaagc acgcttttta gtacctcata cacatcatat

32701
tgcctcaggc tgacccaact ataatctaaa tataaatgat caatttgcca ggtagagcaa

32761
gtgctttcta attttctgtt tatatttgct gtgtctgtct cccgtaactc agaccttttg

32821
cactagacag tacttgtgct caacaaaatc ttcccagttg tttcctctct gattgctttg

32881
cttgtagttc cctgtctcct tttcttcttt gtttcagagc ttctaatctt catcttggct

32941
ctgccccagc tgtctcaaca gagaattcat tggtcatcta atcaaacgag agagtagtcc

33001
ccaccccctc agcctctctc ctaactagta tggatcttag gagagctatt tttgccagcg

33061
aaggtaaagt ttctgaagct tccttttacc cctgctattg ccccgttact ccatagtcac

33121
tgtttcaggc tgccttgggg caaagctctg agcctgcctc cgtggaactg tcagaggagg

33181
caggagacac aatcccacct ctcaatgtgc aaatgtggca tttcgaattt gcaataggat

33241
gagtaaattt attttctctg agactttaat gagaccatgt gctacaagta cgaagtgtta

33301
tcagagttgc tattatagct gcagcttcaa taatgcagaa aaatcagcta tgtgccatga

33361
gaatttattt cccaagaata cgacaatgat ctctgttgtt gggaaagggg ggattggtcc

33421
atgtttcctg ccatggtaaa taactagaag cttggcctga atggacgccg aaaccgcagg

33481
tgtgtactat caccaaataa aatccctgtc aaactggctt taatttcata ggatcagtcc

33541
ccatattttc tttaacttct ctgccatagc atatatagat gccatttttg ttcagttttg

33601
tggcttgagc aaataactat cacttttctc gacagtattg agcagaaggg ggagacaggg

33661
aagtatgaag tgtgtctgtg aacaggctgt ctcatacaca catccagtga gctggaagac

33721
acaagggaga aggacgaatc cttttcatag gaggtgtgtg tcttccaggt tgctggcatc

33781
atctctgctg cgattgtgat gatcgccatt cttgccctgg ggaagcttct ggaacccttg

33841
cagaaggtat aaccctgctt ctctgcatac cgattgcata atttcccttc actactctgc

33901
taccagataa ataacaggag atttaacaat catcacatgg aaaaccattc cctgaataac

33961
acagccttct ctgtctctct tggcagtcgg tcttggcagc tgttgtaatt gccaacctga

34021
aagggatgtt tatgcagctg tgtgacattc ctcgtctgtg gagacagaat aagattgatg

34081
ctgtaagtca cctaccacct atatttatct gaaataagat ttggttctta tatgcttcct

34141
gccatatcac tatattcccc ccatccccta agtctcactt gtgctttggg aactccagag

34201
gagaaattag aattgbgggg ataaatcaaa gccatgaagt cttccatgtg aactgcattt

34261
tgtgaagatt ctgtatctct gggaaggtca atttccagca agaatcccat atgaggctca

34321
ttcatacacc tttggccttc taaacacaaa aagcaaaaaa atgtttaaac accctagttt

34381
agaaggacaa acaacataca aaacaatgca aaaacaaaat acaaaatgta aaaacccacg

34441
ctgactttaa ctctgactaa cataaccttt gcaactattc tgagaaacta aaaatcagaa

34501
gctaaatcct tcagagttcc tctctaattt aaaccataaa aagaatgaga agacttccta

34561
catattgata tggaaaattt tccaagacaa atcgttaagt gaaaaagaga ccagaataga

34621
aatgctgggg aaaagcacag acacaggcag aaataaaagc ggatacaagg agggagggaa

34681
gttgggaatg ggtggagaag ggggagggtt gtgagcaaga gttttcccct ttttaatgat

34741
aattccctta tgaaccatac aaatatatta gctattcaaa aatttagaaa taaataaaat

34801
gggacagttg gtcttaattg agaagcccag tttctacagc tacttaaata taaaatgaat

34861
gaagtcacaa tatttttaaa aagctgtgat ttggccaggc acagtggctc aggcctgtaa

34921
tcccagcaat ttgggaggca ggaggatcac ttgagctcag gaatttgaga ccagcctgcg

34981
taacacagtg agaccttgtc tctactacaa ataaaagatt aaaaattagc cgggtttggt

35041
ggtatgtact tgtgggtagt cccagctact tgggaggctg aggcgggagg atcacttgaa

35101
tccagaagat ggaggctgca gtgaactatc atggtgccac tgcactccag cctgggcaat

35161
agagtgtgac cctatctcaa aagaaaaaaa aaaatgtaat ttgtttgtgg atcattgatc

35221
ttatttttat aggtagttat cacatgatgg tacctgatac attaatataa ttcttttcat

35281
ttctattttt ttccctaggt tatctgggtg tttacgtgta tagtgtccat cattctgggg

35341
ctggatctcg gtttactagc tggccttata tttggactgt tgactgtggt cctgagagtt

35401
cagttgtgag taacgtaaaa cccagatttc ctataaacag aacaacacac tctgagcttc

35461
cttataccat tttgataaat atagtgaagc cactttcttt cgttatagtt actgtatatt

35521
gagtgcttct atgcattaag cagacagtgt tttacagaca tacttaatct tcaaaaatag

35581
cctatgaata gttttgatta gtctcattct acaggtgaga aaagagaaat tcagaaaagc

35641
taagaagcat ccctaagatc acacagctag tacgtggcag agctaagatt tgaacctatg

35701
tacctactca tgtcctctac tgcbgtgctc tccttttagt tgtggtaaga ctaaaaagta

35761
catagtttag ccaaaggctg aagttgcttt gtagtttctt ctttaaatga gatgaggaat

35821
gtaaggcgct cggccccagg cttgggacaa gacagcbgtt atatattata gttcattttc

35881
ttttttaaag ctagtaacca aaagttacat aacccagaac aggaggactt taaaatagct

35941
gatgacagcc aaaattcatt caaatctctc atataaccaa taaggcatat aaccaataaa

36001
ccacacaatt atgtgaagga aacaattagc tcatatgcag agtgaaggca gcaaagacat

36061
gatttaaata atggaaaaca gcctgtgagg gaaggtgagg agcctgaagg tggttttttg

36121
gttggttttg ttttgattct agagaggcct tagttaagtg ccctcctggg cctagagggg

36181
aacagagtct ttctctccct cctcaatgtg tccatcgtct ttccagactt ctggcccctg

36241
ctctgcctgt gcttgggccg tgaaagaaga agacacctgg aaaaacatca agatagatgt

36301
cttcagctta gcatccgctc acctctcctg tcccaccagc cagttctcct tcctgccctc

36361
cttccctacc ttggcatatt ggtgcctacc caaaaggctt gtgttttcta cctcagcatc

36421
ctaaatgatt gcccaagggc ctgagaaggt ttgcaggctc ccaaagttct caatttgctt

36481
ctaggacacg tctcagaaac gctccttaga agatgcbgtc tctcatgctg tatatgcctc

36541
agtgtctatt ttttcttgtg tggatgtggt tggaaaagaa gggttttaca gagagagatt

36601
agcttataaa cttttaagtt aaaaatcagc acaaacctgt aagccaagga ataactggtg

36661
gcacatttta gctgctagtt tggtatctag gcttttagcc aacaaaaagc agtatcctcc

36721
acagtattta atttccagta attatcatgc tgatccagag agcacaatgc tgaaagtaca

36781
ctaaacagat actctttctt caggaattgt atttagcatg tctctagtca cacatgaaga

36841
gtcacggaat ttatctgatt gcatcaggaa caagaaatca atagtctggt tgacaggaag

36901
gacttatttc tggtcctcca gtctcctatt tctataaaaa atgactaagt cacaaagaag

36961
cgccaggcac tggaagaccc aggggttaaa gacagaggct ctgctgccct ttacctccag

37021
gccttttctc acttctctta agaagtttag ttaacaataa aaatcaggat aatactgatg

37081
acctttcagg gttatggcag ggcttaaata agatttcaca tgcgtgaaag ctctatgctt

37141
atcctataac gtgttgtgca cgtgcaagta tgatgctcat tatttctctc agccatcaga

37201
agagaggcac agttctcccc tcccctgccg attccacaca aacaccagct gttcatttca

37261
gagttagcta caggaaaatg tcatctgcaa taaagacaga gtccaaaaca ccagaatgat

37321
gggctcttta gtagcbgttg tttttaactt tttattccaa aatacggctg ttccaaaaaa

37381
tcttgacctt gatatttttt cttctagtcc ttcttggaat ggccttggaa gcatccctag

37441
cacagatatc tacaaaagta ccaagaatta caaaaacgta agtacctttg tgagacattt

37501
gctggacttg ggtttactag cctgaagttt cagcagctcc attttacgta caaggtagcc

37561
aaagggagaa aatgcctatt gggaaagtct gttagtccac agggagtgtc atgaaaactt

37621
ttgatccagt gcaccttctg acacccatgg cttatgtgaa ttttgtctat gctagctgaa

37681
tgtctttttt tttttttctt tttagatgga gtctcactct tcacccaggc tggagtgcag

37741
aggcaggatc tcagctcact gcaacctctg cctcctgggt tcaagtgatt ctcttgtctc

37801
agcctccgag tggctgggat tacaggcagg tgccaccacg cctggctaat ttttgtattt

37861
ttagtagaga tggggttgca ccatgttgcc caggctggtc tcaaactcct gagctcaagt

37921
gatttgcccg tcttggcctc ccaaagagtt gggattacag gcgtgagcca ctgcacctgg

37981
ctagctgaat gtcattttaa tataaaactg ttgtaagagg aatttaaaaa taataggcaa

38041
tttctagatg ttcatccaaa attttgttta tctggtatat aattcttatc ttctgtaaga

38101
ttttctttat tcagttctaa caagagatta tcaagttctc tatgaccaag accttattat

38161
ttgacacttt gctttatcct tggtattaga agaaataaaa tatgacacag gaaatgaaaa

38221
acaaagaaat taaacatccc attgatggac ttgtgtcacc tgcaaataaa attgcttagt

38281
ggtgactagg ggaaacaaag ataaaaaagc agagaaagta aatcaagaaa atacaaattt

38341
agcaaataat aataataata atatcaaccc taggaagttg tagtctaatt ttaccttaac

38401
attaaaaaaa gttggacctt gaaactggga tttcagtagc tgctacttaa tttatttccg

38461
tgatctttct gttatgttga gccaagtgcc attaagagct aaaatgattt agagattttt

38521
ttggctttgg ggagggagct ctaagctgag ttagggaatt ctgacttcta ggctccatct

38581
tggtgagact ttgcccaagt cattcagcct ctcaggacct cagttttctc atctgaagca

38641
gctagactaa aattgctgat tcctgaagac tagaaaagtc tatgattctg tgattcctgg

38701
gttctatttt gggtgtggcc attgtatgtc agggtgagaa cagatgatat cataggcctc

38761
agttctgcaa atcccattga ttttgctttt tttctttgct acttttaaag aatgttagca

38821
aaatcaggag ggtcagtggt atgaacttca ggcaaatcat ggcactgttc taagcctcag

38881
tttcttttct ggaaatcaga gggttgaata aattgctttc taaggccctt tctaactttg

38941
accttctatg agactgtaga ggtccaagag tttttgtaac ctgttgtctc cctattcaag

39001
aaaagttgta gaggccgggc acggtggttc acacctgtaa tcccagcact ttgggaggct

39061
gaggcgggtg aatcacttga ggtcaggagt ttgagaccaa cctggccaat gtggcaaaac

39121
tctgtctcta ctaaaaatgg aaaaattagc tgggtgtggt ggcagcacct gtaatcccaa

39181
ctacttggga ggctgaggca ggagaatccc ttgaacccag gaggtggagg ttgcagtgag

39241
ccgacattgt gccactgtac tccagcctgc gcaacagagt gaaactccat ctcaaaaaaa

39301
aaaaaaaaag aaaagaaaga aaagttgagt gctgctaccc agctcctctg agcaactgtg

39361
acttgactcc ttgctaagta gccagaaatg taattaaata cttgaggctt gaaattattt

39421
aatcccagac aatttctttt aatgccagat tgaagaacct caaggagtga agattcttag

39481
attttccagt cctattttct atggcaatgt cgatggtttt aaaaaatgta tcaagtccac

39541
agtaagtatt ttatccctag aaatttgttt tctaacctct tttgagactt cattcattct

39601
acaagtattt actggggtcc aatcaggaat aggccctaga ccctcttccc tttgtgtagg

39661
gcaatgagaa ttaaaatata acatccttgc cttcaaataa tttacagtct atttggggat

39721
taaaaaaaca catatgttaa aacccaggta gtaataacta tgccagacaa aaacattaga

39781
gatgtttcta ggcagaattt gagtaagttt caaataagta gtatagacag ttgagagttc

39841
atagaaggaa gagatccagg ttagttggac taacaggctt tgtgcggcag ttggctgaag

39901
gaaagaaatc atgtcaagtg tttgagaact atgtgagctg agagacagtg gaaacatgta

39961
ttggaggtag ggttgcccag ttgcagcaaa aagtaaaata tactagtgga ataaataagt

40021
agaaaatcct ggcaccaaat gccatgctat gctttgaact tggagtttgc ctctaaatca

40081
gtgtttttct aagtgagttc cagggcaaac tgattcagag gaatgttcac agattttgca

40141
ataacaaaag ggctctgtga taccaaggga atttggaaaa cccagactta aactaaagag

40201
ggtattttgg ggtgtgtgtg tgtttctgtt ttgtctttta ctgtcttgga gcctttgata

40261
tgctactgtc ttctcagagc ttctgggtag gagtagggta gcctgggagt agacagagat

40321
ctactccatc agaccttaca atttcttttt tggcaggata gctcaaggaa ttataccctt

40381
tgagaaatag cctttccaga taacagttgc cattaataag ctttaggtgc caggcatttt

40441
aagtaacttg acatttattt ccaaaggttg gatttgatgc cattagagta tataataaga

40501
ggctgaaagc gctgaggaaa atacagaaac taataaaaag tggacaatta agagcaacaa

40561
aggtgagatg acatctttct tttccccctt aaattatttc ctttccctga tgagagcagt

40621
tagagggtct aaaattaaat ctatcctctt tagtatccag atgtgaatga acaaatgaca

40681
tgtacgtatc aaagaacaac tgagctattc ttataggcaa gcgggagtgg aagggaatga

40741
aataaaatca gcagcgctgc ctggaaacac aggatgtgat ttttttcccc accatgaaca

40801
gtgtctgcat tattttctat actttatttt tactgaaagg aacaaaataa gtgcaaattc

40861
aatgccagaa aactacccac catagaaggc agtctaagtc cataaacttt tggagctgtt

40921
aacttttact cagattcttc tggccagtgt atttcttggc aaagttccac aatcatccag

40981
aaaacaaaag tttcctggct cctctgttct cccagttttc ttcctagaca acatcaaagt

41041
ttgggctgag gtgaaaccca tccttaaaaa ttcatctcct tgatgtcttg cttaccaagg

41101
aacagtgtgt aggtcttttg gataatttga tatgaatggt tgaaagattt caaatctttg

41161
acaattaagt tgacagtgtt ttcttcgttt agaatggcat cataagtgat gctgtttcaa

41221
caaataatgc ttttgagcct gatgaggata ttgaagatct ggaggaactt gatatcccaa

41281
ccaaggaaat agagattcaa gtggattgga actctgagct tccagtcaaa gtgaacgttc

41341
ccaaagtgcc aatccatagc cttgtgcttg actgtggagc tatatctttc ctggacgttg

41401
ttggagtgag atcactgcgg gtggtaaggt tctggttttc tgaattatac atttggagct

41461
ttggcaatag taaaatgatg tgggttgtcc agtattgcaa cagggcaaat acatgggctt

41521
tgtaattttt ctaggtgaat gcttttgtaa aaaagtgtaa tattttaaag cataggctct

41581
ggagccagac tacctggggg agatactggc ttcaccactt actagcagta cgaccctggg

41641
caagttgctt aatctgtcta tatctcagtt tcttcatctg taatatggag gtaatgatgg

41701
tatctacctt cacaggttgt tacaaggatt aaataagcta atagatataa ggtgtttaga

41761
agagtgtctg gttcaggctg ggcatggtgg ctcacgcctg taatcccagc acttcgggag

41821
gctgaggcag gtggatcatg aggtcaggag ttcaagacca gcctggccaa tatggtgaaa

41881
ccccgtctct accaaaaata caaaaattag ctgggcatgg tggcgcacac ctgtagtccc

41941
agctcctagg aggctgtggc aggagaatcg cttgaacccg ggaggtggag gttgcagctg

42001
agattgtgcc actgtactcc agcctgggtg acagagtgag acttcatctc aaaaaaaaaa

42061
aaaaaaaaga atatctggtt caaagatact ccccagcaaa ttaattcaca tttattatgt

42121
tttatctttc tgagaatgta taacaagtgg tatatgaaaa gaaaaaaatg ggcaaaagtt

42181
tattaagtat tacatttcta tttgttatgt taacagcaac aggataagga ataccaggtg

42241
tatgttagga ctggaaaagc caggcattat taagaggtta gagtaggaag caggtcagac

42301
atctggaagg tcaaagcaag agttgaggag tatgcaggat agaaacatta atgatatcag

42361
aaaccagtta tgcaagctga agttcattaa ttctgtcaac aaatagatgt gaaatgccta

42421
atgtgtactg agcactctgc caggcacaag agactagtga tgaagtagac acagtttcta

42481
cctacgtggg acttagcagt ctggaggaga aggcaaacat taagtcatct tataaataac

42541
aattgtagta agtgctccaa agaagatgaa taggacatca cctgaagcat caagttcagt

42601
gaagcttcag gtaggtatca aaagggtcag gcagaaaagt aagcaggtca agacaccaac

42661
aatcagatgt aataatataa agctgactcc taactgaggt tccacttagc taaggcttct

42721
ttgctacctc tataagggga ggaaatgatt ccaggatgtg ggtactaggt aggtagggta

42781
gagaagtgat tgtgcttggc aaaagagtat gagaatatgc tgacaggttc tgttctagtt

42841
ctcttagcag attttgttat tagctcattt gaaatcactc ttgttctttg ttgtacattt

42901
cactctaagc attggctgag atccattgta gactatattg gccagagagt tcaatgaatt

42961
acttttgggg acagtcttaa catatttaat gccagaatat ttcccacaca acgaatattt

43021
actttcaaat attataatga cagttatgat agctaaagaa gactccaaac tttatacttg

43081
aacagaggtc ttgatttgtt ttcctccata attctcaaat tctcttttat tattgactat

43141
gggtcttgtg tcttgacttt ttaaaattaa atgtttattt tgacataatt gtaaattcac

43201
atgtagttgt aaggaataat atttagatcc tatatacccc ttacccagtt tctcccaatg

43261
agtaacatct tgtaaaactg tagcataaaa tcacagtagg acactgacat tcaaaataga

43321
ggccttgact tttaggtcaa tagtaacatt ttgaacccga taagcatagc cacacccata

43381
tctcttctcc aatcagcagg gcctatatta agaagcctcc tgtactctct tctttccaca

43441
aatgcttatt tagcacctcc acgctatcaa gtgcbgtgct attgagcgct ggatgttgcc

43501
atctcttgag atataatcct aattatacca ttactgtagt ttgaaaacct ccatggtttt

43561
gcaataataa cctttcctta aagtcctgat taaccatgaa agtaataatg tttctcctga

43621
gcaagtaact gaatgctact gaattatggg cagataaggt tgttaattgt tacaaactct

43681
ccttttttat ttttagattg tcaaagaatt ccaaagaatt gatgtgaatg tgtattttgc

43741
atcacttcaa ggtaaataca tatatctaca tatctacctg taagactttc ccgtaagccc

43801
tttctcctat ctgggactgt ggtcacatta tgtctgaagg cctttttttt ttttctttta

43861
aagatctcaa ttgtcattat ttgcagttct ggaatctggc actgcttcat tccataaaac

43921
agaataagtg ttccaaggaa ctaagcagga gttcagtatt atacacagaa aaggccaaag

43981
acagcaaaag caagcaacaa agagtatatt agtccattca aagttacttt cttgtaagtc

44041
agagacagtg agacagaaca ataggaaaat aatggattag ttaacatgag gtcatgtcag

44101
gatacttttt tgtatgagga ttattgcaga ggaagcttta ttattatgcc aactggaaat

44161
ttaaactgtc ctgttttagg aaatttgcta ttacctctct ctcctgattt cttcaagtat

44221
cagataacaa tttagtttag gtttgataac ttgaaacttt agcatgagtg actccatttt

44281
gatttttagt cttgtctgtt gtcgtctagt gcgggagctt agtctaaaac aatggccttt

44341
tatttttatt ttttatttta ctatgtgcct gtgccttgca tgaccccagg atgggcacag

44401
ctgcttggcc cctgagccac cgaaggctgc tctactcctt cgttctggct actaaaagct

44461
gcaaagctct gggagggcaa agctcaagaa gactaaaaca atggccttta ccatttttgt

44521
ttgatgattt tccccgtttt gatcaggctc tcacctaggt aagagtgaac aaaatgtagg

44581
agatcagtgc tactctgtta ccatcatttt gggtttctgg tctcaggagg tcatgtgtag

44641
cttatggtgc cctcctcatt atcatgtatg tctctgagtt tttgttgttt cagagagaga

44701
ccattcgatg tctgacaggt ggctttttgg aaacatttaa aactttgaga gggtataatg

44761
taccaggaag actgctatta tgactatcag ggagataata ccaagggttt atagtatgct

44821
ccttagccag gattctcatg aatcaaacca actaaaattg aatagcctga caaggagact

44881
acctgtttta accaagaagt cttctctgta gtacctgatg tatttatata tgtggaacaa

44941
gaagtgtcac ccaactgcac agatgcttcc ttgttgagtt agcaggtaat ctagcattcc

45001
atgactggtt aaattaaagc agaaagtgta agttacccaa agaagctact cattgtgaag

45061
ttttaactac agcactatcc tgccaagtga aagaggtagg cacaagtaag ggaaaattaa

45121
aagggataag catcttatga tagggagtct tgttctgaca gtcttggagc tgtctacagc

45181
atgaagttga caacttcttg ttttggtttg tagttttatt gtctctagtt gtggcatcca

45241
gcattctggc gaactctcta tgtggcccac agtttaagca tgagattcat ctcttgaaat

45301
ttacactgag ttgctcagct tcagcttaca gagcttcagg aactgagtag ttcttggtct

45361
tcattggagt gttgtagcca gatattagtg aaagctaaaa gaattaagaa tccagctcag

45421
tctacaggta gataataaaa actcataaat attgaacagg gctacagtct aagaacagtt

45481
ttactatgct tttcttttga accatatgtt tttctttcta tagtcacctc catttctatc

45541
aaagacgatc atggtagacc aatttgttta caaaataagt ttggtctcaa acttggcctg

45601
attgattatt tacacagtac agcaagaata actacatagg tgactccttt caaatttgct

45661
ttgccaagcc tggcgaggta ttgcttgcct gtgagcccag ctacttggga ggctgaggtg

45721
agaggattgc ttgagcccag gaattcaagg ctgcagtgca ctatgattgt gcctgtgaat

45781
agccactgca ctatagcctg gacaacacag tgagaccatg tctccaaaaa ataattgctt

45841
tgatagaaat tttgacaagg aatctcagat tggacttttt aaaacgtctt gatgctatga

45901
agtcaaacca aggcagacat taggctttgc ctgatgtatc taatatcttg aagttactgg

45961
gcctcccagg aaggaacgac tttttattca ctcattgtaa ggctagcagc ccttgaagcc

46021
aggaattctg tgcacatttt caaatatgat attctattca aagccttgat aatataacca

46081
atgttttcca attgtattct atttaaaaga acagattcta ttgaactttc atgtaaataa

46141
tcatattgcc ataaaaataa gaatactcac aaagagtttc caaattctgg aaggatcagg

46201
tagagaggaa aagcaaatgt ttcaattttt gtttatgaaa gtatgcttaa caaggctggg

46261
tgcggtggct cacatctgta atcccagcac tttgggaagc caaggcggac aattgctttg

46321
agctcagagt ttgagaccag cctggcaaca tggcaaaacg ccgttactac aaaaaataca

46381
aaaaattagc tgggcatgga gcctgaggct gagaatcact tgagctgggg aagtggaggt

46441
agcagtgagc ccagatggtg ccactgcact ccaacctggg tgacagagtg agaccctgtc

46501
tcaaaaaata aaaaaaaagt atgcttaacc aagtggctgt aaactgcaga tagctttaaa

46561
gaaaaatttt ctttagatct ggaaaacaaa tattaaaaga accagcaatg tttcaaataa

46621
aaaagccata aaacctgtaa ttcttctcca tcagttcatt cagtctcatg taattaattc

46681
ttgctctgtt tgatcttggc tggtagttta attccaacga atggtatgaa ttcaaagtta

46741
ttagaaacct gtatttgtca gagttctttt cattcttccc atataactct ttgaagtcac

46801
agcactttag aattataatg gcttacaaag agctttcaga aaaagtatca gaacaaaaca

46861
attaactgtg gacaacaaga cttaaagtgg ctatatttaa agatctgatg tgagttaccc

46921
aattgacaag gatatttgga tatttctgtg gcacacaaca atttaaaata accaaaatta

46981
tgactggtag catttatacc aagacctatc acatttctag gaatgttata taattttgga

47041
acatattaat aacatatcta taaaaatata gcacaaagaa agttaaacat catttcttat

47101
tttaacagtg cttcccatat aatttaacct atcagataag gccatttggt ttaacatctc

47161
tcttttacag attctttaag aaattccagg gtcctctgga acatcccaaa gttagttcaa

47221
ggtcaaaaag acttaatttt gatttttgag aagtttgtca aataccaaag gtttaaaaca

47281
tttgatcaaa atcggatcat aggtcactat gaaataaaac caaagtgaaa aaagagttca

47341
aaggcaaaaa gcacaagaag agttatattg atgaaacatg aaatctctgt tttctaggcc

47401
agttacctgg aagagaaaat cctctcacaa ttttctatta agagtaaacc aatcctctga

47461
gaaaactcta ttgttccaac acataggccc acactttagc cttccatcag tgtactttaa

47521
tattaatgct caatttttag aaaaacttat aaataattcc cttctacttt tagccaactc

47581
aatcacataa aatttttcat gatatttatc ttctacaaac cttctacaac ttgcttaaac

47641
cttcatttgg tcctatactt ccttttttaa aattggcatt gtaccttagg acaaagattt

47701
acttttcttt tctccttatc attttgacca tataaggtta tctcctatac aaaagaaaaa

47761
attactctct tttcaatttt ctttatctct tcatacttgt aaatttcttc tcacatcttt

47821
cctacctagt ggttccttcc tgccttgttt tgatttcctt cataagtcca tatttagaaa

47881
caacctttaa ataacctctg attgccaagc tagagttaag ttttaaataa ataaataggc

47941
cggtcatggc ggctcacatc tgtaatccca gcactttggg aggcaaaggt cagaggatca

48001
cttcaggcca ggagtttgag accagcctga gcaacatggt gagaccccgt ctctattatt

48061
ttttttttaa aaaacaaaaa gcataaaaac tctgagaaca ttttgaaccc agaaagatat

48121
tacttccaat ttgtgccaca gagctggtaa tgtatggaaa tgtgtatctt gacagtgggt

48181
gggggtgggg tgaatattga caatgggggg atgttgttat gaggagagca aagctggaga

48241
ttacttagat tccttagaac aggaggactc tcaagggtgt gagtctctgt gtgtttcttt

48301
atgaatgtat gtgtgtagga aagtgctaag gcttaggttg aattctttag cagcagagcc

48361
caagatgggg attcttgcac aagcgattta ttgagaatac atctgaggaa atttatgaag

48421
cagtgagggg agcaggatag ggaaggggaa gaagctgatc aaagacatgg tttctgaagt

48481
ccagcgtaga tccctgattt cacagggagc accaccacag gaagagtacc agaaggttat

48541
gcctccttga ggcaagagga cctgctttct cccccagtaa tgagtcagtc agtggctgca

48601
ggccagccat gtgtggggat gaaacctccc agttctcttt atttacttat ttatttgaga

48661
cagggtcttg ctctgtcacc caggctggag tgcagtggtg caactgtggc tcactgcagc

48721
ctcaaactcc tgggctcaag tgatcctccc atctcagcct cctgagtagc tgagactata

48781
ggtgcacaac cacacctggc taatttttgt atttttttat aaagatgggg tttcaccata

48841
ttgcccagaa gttctgggtt caaagtgatc tgccctcctc ggcctctcaa agtgctggaa

48901
ttacagaccc agtcctcttt agatgacaca gctcccaacg ggcaagggaa agtctccaga

48961
gaagggcaca gctgtgaaac attggcagcc tggcccacag cagcaggagg atggatacac

49021
tggcttggcc aaagggacgt gatcgtccac aaggttgact acgaccagtt atgggataac

49081
cattctatat actactggaa aagaaactgt catttcaaat ctgggtcaca ttttggataa

49141
gagaaaaata aataaataaa aggaggagct acaaaaactt agtataggtt gatgctttaa

49201
aatttctttt cttagcbggg catggtaggg tgtgccctgt agtcctagct aattgggagg

49261
gtgaggtggg gggatcactt gaacttggga cgcggaggtt gcagtgagca atgatgccac

49321
tgcactccag cctgggcaat agaatgagac tctgtctcaa aaacaaacaa aaatttcttt

49381
tcctaggaac taacaaaaca ttgtgtcttt cttttgaaga ttatgtgata gaaaagctgg

49441
agcaatgcgg gttctttgac gacaacatta gaaaggacac attctttttg acggtccatg

49501
atgctatact ctatctacag aaccaagtga aatctcaaga gggtcaaggt tccattttag

49561
aaacggtaaa tattcaacct ttctacagat gtatcttttc taaactatca tgatttctat

49621
aaatggcaaa cattacacaa gtctagtcta gcbgttgaat tttaagctac ctatataact

49681
tcatggagcc tcagtttttt catcagtaaa atggaagtaa aaacattaac cttgctaggt

49741
agatatgaag actaaataag atagtttata ggaaattacc tggtagtacc cagtactgaa

49801
tagttctaca atgtgtaggt ttattaataa aagtgggcat tagctataat gccttttaag

49861
aatattgaat cttggatctt ttgtgatctg ggatttgtgt acataaattc cacttaaatt

49921
ctcagcaatc tggaaaacct tgaattataa atgtctttaa acaggatcca ccaggccata

49981
agtgatcttt gaaaaagaaa tttaaaaatc aagccacaaa gaagcccagg gttaattttt

50041
ccctacaaaa tagaataggc cctgatggga ggcctcatgg cacaacagta gcgcatctgg

50101
ctccagaata ggccctgatt tcccatgggt attattttgt taatttttct gtcaaatacc

50161
cagaagaggt gagcattctg gtctggttca ttgggcttgg cctaatggtg ctcctggtgg

50221
tacaagaatc tcatttctca tagtgaattt aggaaactaa agcaaatacc tatcaagata

50281
taataacagt aatgattcca gtgacatcgt ggatatttta aattgcttcc catttttcta

50341
aaagtagaat aagtagatcc ttattgtaga ttggcagttg attgaagaaa actaacttag

50401
gaaatgatat tatattattc tttttaggca ctggtagtgg agagattgtt ctatttgatg

50461
ttccttggta aaatactagt cctaactacc aagcbgtgga tcttaaatat aaaaaaggaa

50521
aaaaaaaaaa gagtaaagct acaaatctaa agaaaaaaaa actgtttatc attgaaaatt

50581
cataaacttt ttctatccaa cttaaaattc tctaacccat aggtgataag aaagttggat

50641
catatgaagt atcctttaag agatccacat taaaagtaaa acagaaccaa ggtatcaagt

50701
tctttctcaa catgaaagca gttattttat ttgtttatac ccattcttac taagatttta

50761
ggctatgaat gtcataaaaa ccactaacca agagtgtatc tactaggtta gactcactct

50821
tgtttgcaat cagagaggta ttgtgagtgg ctgggatgga tttttttgga ccttaaacaa

50881
atagactaag cataacggaa tgcttgtatt acatacttac tggtccacta aaagtgggtt

50941
ggacattcct ggtggcctgt gagatcaaga ggcttatatt tctgtgtctt ctcagagtct

51001
agcacaaagc tttatatgtg ataagtaggt gaatgatgat aaactccttc aagagggagt

51061
ccctctgtat caaagatatt gtgactgcaa tgacacaacc ttcttcctat ccctttattt

51121
taccatcaca ggactatctc aggacacaac ttgtagttag acttatcctc tacctttccc

51181
attatgtcat accatttgca cagggactta accctctaat tcattctcat actagctaag

51241
agaattgggc tatttgtgag ttgaaaagta gctaagtagc atttcaaaat gttattttag

51301
cctggatata tatttggagt tgctttgaaa atgtcctttt ccatgcaaaa cacaaagcca

51361
aaattgtcgt tggtttcctc tgtgtagaag attaaattac atgccacctc taaacagtag

51421
agcttttctg aataaccaac ttggtccata gacattggtt tccatctcca atagaattaa

51481
tttccaccca attccatttg tggctgtttt ttgtcatcag tgacaagctc ttcactgtgc

51541
attcattgca cactcaacgc tgtgctaagt gctcttagct tagccattga gagatgcact

51601
attgactgct gaatcattta ggcagagggg gtgacttgtt aagaggcata cactcaagag

51661
gttggggaag agagctgaaa aggagtttac acaatggaga actataccag ttcacctttc

51721
aatgtgcaaa aaaatgatat acaaaaaatt ttagttggga aatataaaag aacaatacag

51781
ctgaagagga ttctgaagta tgtaaagaca gatgagaagc accaggaaag cttcaaatca

51841
ttttcagtgg agcatcaggt gggttgatgc tattctattt ctaccctgtg ttctcttttt

51901
caagatcact ctcattcagg attgtaaaga tacccttgaa ttaatagaaa cagagctgac

51961
ggaagaagaa cttgatgtcc aggatgaggt atgatcattt tcttctgaag aaaatatttg

52021
aattacattt tgaataatta gagtaataca aatagtgaat atatctgatt aagaactgtc

52081
agggaacata attcccccaa atgcagaaaa gatggcttca tagcagggaa aaagagaaaa

52141
taagaattct cccttgaaga cattaagtac ttggggatct tttgtcccag gcatttgggg

52201
atgatcagca actggcaaga gccaacacac tgctcctgat ttgataccta cacctctgca

52261
tactgctctt ctagagatgt aaggccatgg ggtaggaaaa aaatgaatag aggaaacttc

52321
taagctagga actttataag cctcaggaat agtatgtgag gaacagaaac cctatgacct

52381
tccttcatat gactgataaa ggctttaaaa acacactctc cccaccctag actgattctg

52441
tgtatttcag atgctcttgt gacatcagac tattcctagg aaacttgtct gaacttgtag

52501
catctgagta aattttgcag cttcgccact ggataagagg tgaacactga aggaagatca

52561
cagaattgta aaaagttgaa agatttctta gaatcaagta gtctaacatt ctagcccatg

52621
cagaaatcct tcctacacca tccttgatga atgttcattc agcttttatg tgaacatttc

52681
cagacattgg ccactagcgg cttctcaagg gagtttgtta catggttgga agtctctaaa

52741
tgttacttgt gcttacagaa ctcaatttgg cctttctgta gtaaccacct agtgaactga

52801
gatctgcctt ccttagcaac acagaccttc ccactgaaca gcccttcaaa tatttgagaa

52861
tagttctcat gtctccagca gactctcttc cagttgagac tcttctagtt ccttctattc

52921
cttacaaaca agcagtcagt gcttctctgg tcacgatggg gacacaaaac cctaaatgcg

52981
gccaggccag catggagatt attcaaccat gacctacctt gatctcatca agatattcct

53041
attactacag cttaaaaatg tgtttccttt cataatagca acatcagaat tttagcttct

53101
attgagcagg ggccaactaa agactggggc attttcatac aagctatggt ctagtagagt

53161
tccctagtta tatttattta attgagcttt gaccctaata cagaactaca cctatttctg

53221
ctggatttca tcttgttggt tcttgtttac tgacataatt ttgtattatt attagtatta

53281
ttattattat tattatttgt gactgagtct tactctgtca cctggactgg agtgcagtgg

53341
tacaatctca gctcactgca atccctccct cccaggttca agagattctc acgtgtgcct

53401
cagcttccca agtagttggg attacaggcg ctcgccacca cgtccagata attttttttt

53461
tttgtattct tagtagagac agggttttgc catgttgtcc aggctggtct tgaactcctg

53521
acctcaagta atccacctgc cttgccctcc cagattgctg ggattacagg catgagccac

53581
cacattggcc agttttgtgt tttgaatcta acatccagga tattgtctac cccagtaccc

53641
gttacctggt gtcataatca aatctgataa gcctgccttc tctgcctttt tctaggtctt

53701
gaaaaaatgt tgcaaagaaa acattcaacc ccctatagtg aaatcaggca gtaaggatga

53761
caggcagaga tttctgtgga ggaaatacat tgctagagtg aaaatcacag tacctgcatc

53821
ttggcccacc agcttagtga gcccaggaaa gtcattatcg acctgagaag tccttttagc

53881
tccagtagtt tatgactcta tggatatagg gtgccttagt ttgagtaaaa actcatatgt

53941
caacattaaa acttaagact gctatattat aggatattta ttggttgcca cgtaaaataa

54001
tcattcaggg agggtttcta tagatggtaa aacaatatag cacaatagtt tcaagggcat

54061
ggactttaga acaagacaga cctgggtgct agtcctcatt ctgctactta ctggctgtgc

54121
accccagggc aaattactta tcctgtcttc atattagtat cttcatgtaa agtagtaata

54181
ataccacaga gttgtgaaaa ttaaaggata aatgtaaagt aacaagagca gtgccttgta

54241
catagtaagt gctcaataaa tagtaatcat tgctcttaaa taaatccaat taaagtgtga

54301
tgaatacagg ccaggctcag tgactcaagc ctgtaatccc agcactttgg gaggctgagg

54361
cagggggatc acttgaggtc aggagtttga gaccagcctg actaacatgg taaccccccg

54421
accatctcta ctaaaaaaaa aaaaaaaaaa attagcbggg tgtggtggca ggcacctgta

54481
atcccagcta ctcgggaggc tgaggcagga gaattgcttg aacctgggag gcagaggttg

54541
cagtgagctg agatcacgcc acagcactcc agcctgggca acagtgagtg agattcagtc

54601
tccaaaaaaa aaaaaaagta taatgaatac gaaatgaagt ttttacccta tttctattgt

54661
gatgatatac acctaagatg agtagcagta agcaatcaat actataaaaa catatttata

54721
aaaaagataa tgcagactta aggagaattc agttgtatca acactttgtt ttccccttgc

54781
ttccacaggc tatgcgtaca cttgcatcct gaaagtgggt tcgggaggtc tctatgagca

54841
aggaatacaa gacaaaactt cctcaatgca ttgactattt cttcagactc aaaacactca

54901
ttcttttttc tattaagcca ttgaaagaga agcactaaga ctgcttctag gctttattta

54961
taaaataaac accttatccc taacatgggc aaaatggcta gaattattca gacgatttgg

55021
cagcgtccag ggtaagctgg tgttataata cgctgctgat ctacatcaca gatttgctaa

55081
taatgttcac gtgggccctg gcatatctct gttcagttag agtgagtgct gacccaacag

55141
cctctgtggt caagcgagtc acgaatgatt aatcataaag aaaaatcagt ttttgactga

55201
cctggatatc catgagctgc actgatcacc atgtaaggtc acatttagta aatgctgaaa

55261
taaaatgatt aatgcattta tcaataaaag cctttgaaaa tactttggat aataaattgg

55321
agttttaaaa atgcaaattt gcttagtatc taataatgaa gtgttattac atatagccgg

55381
aattgaggat ctctttgatc ctggaaatgg tttacctaaa agctacagaa ccaggccaat

55441
atattttgaa atattgatgc agacaaatga aataataaag agattttcat ggtttataaa

55501
aatctttttt gatatgataa taatcatgat cacaactgag atcaaaaaaa tatatgacag

55561
attattttgt ttaaaaatgc agttttaatt atcttagtct atagaaatga tcattgcatg

55621
gaggcatgta taggtatgat ctgtgtaaaa tctgacataa aaacagtgct attctgagtg

55681
aaaatttttt tgatgtgctt acataaccat ggtgattaaa atgagtttat attttttctc

55741
aaaaatttta gcagtgtgta aagtaagtaa tctttaactg aactctgacc acttaaaaaa

55801
aaatctaaaa attgaactac ctatagtagt ctgtgtttaa agtgaatttt taaagacaaa

55861
gcattctaaa tgaactcaat ataaaaacat tcatttggaa tgtacatact gaaaaataca

55921
ggtttttttg accaaaagtt tttatatctt ttctttttat ttattttttt cctaagtgcc

55981
aacaattttc tagatattat atacaacaca ggctttgatc ttggggactt ttcccatata

56041
tttcacactg gagtgaatga agttgtactt catttctaga gaaaagttat acccaggtcc

56101
ccaattgaga atgtcttgct tgattgaaaa cgacatcatc ccttggtata ctccagggat

56161
tggtttcagg acccctgcat ttaccaaaat ttgtgcacac tcaagtcctg cagtcacccc

56221
tgcctaaaga tagaatggct tctctgtttt tcttctgaaa tacaaccaga aacaatgtgt

56281
ctatttctga aagaatagga ttaatgatca tacaaatggg ttaatcctga attctggttg

56341
taaatctggt tacagcataa ctaggattat aatgctgcct cattttcaca gcactacttg

56401
cttatattga caacaaatca tctcgctaaa gagtgaatgt aggccaggcg cggtggctca

56461
tgcctgtaat cccagcactt tgggaggccg aggcgggtgg atcacgaggt caggagatcg

56521
agaccatcct ggctaacatg gtaaaacccc gtctctacta aaaatagaaa aaaagaaatt

56581
agcctagcgt ggtggctggc gggcgcctgt agtcccagct atttgggagg ctaaggcagg

56641
agaatggcgt gaacccggga ggcggagctt gcagtgagcc gaggtcgtgc cactgcactc

56701
cagcctgggc gacagagcaa gactccgtct caaaaaaaaa aaaaaaaaaa aaaaaagagt

56761
gaatgtaata gtcttgcaga aaatgaatga atacctttgt tcaataaagg aaatatgcac

56821
tgctcacttt tttgaaggaa atgccaaagt tacgttttac aacaaggcta gagtttgtaa

56881
attctgggtt catttgtgat gacataagtc agcaaactgc gggaatactg tctcttctat

56941
gtattttgtg aatagtaagc ataattttag ttttgtatta tcaatgaaaa tttcacttga

57001
aattaaagct gccttttgtt atatttttaa cctataggat aagattccag tattgtatat

57061
gagttttaac aaattaaaaa atcaaatcat gtacatttga aaatatttgc acacatttaa

57121
aaataaatgt aaagttgtct tttaaactac tcggatgtgt cctttctgaa caaaa

Otoferlin

To date, several hundred mutations in the human OTOF gene have been identified to cause profound prelingual deafness DFNB9. Such mutations are the cause of deafness in 2-8% of people that are born with an autosomal, recessively inherited, non-syndromic deafness in different populations (Rodriguez-Ballesteros et al. (2008) Hum. Mutat. 29 823-831; Choi et al. (2009) Clinical Genetics 75 237-243; Duman et al. (2011) Genet Test Mol Biomarkers 15 29-33; Varga et al. (2006) J Med Genet 43 576-581; Iwasa et al. (2013) BMC Med. Genet. 14 95). For example, two substitutions in exon 15 at positions 490 and 515 in the conserved C2C domain of otoferlin cause DFNB9 (Mirqhomizadeh et al. (2002) Neurobiol. Dis. 10(2): 157-164). Migliosi et al. found a novel mutation Q829X in OTOF in Spanish patients with prelingual non-syndromic hearing loss (Migliosi et al. (2002) J. Med. Genet. 39(7): 502-506).

Additional exemplary mutations in a otoferlin gene detected in subjects having hearing loss and methods of sequencing a nucleic acid encoding otoferlin are described in, e.g., Rodriguez-Ballesteros et al. (2003) Hum Mutat. 22: 451-456; Wang et al. (2010) BMC Med Genet. 11:79; Yildirim-Baylan et al. (2014) Int. J. Pediatr. Otorhinolaryngol 78: 950-953; Choi et al. (2009) Clin. Genet. 75(3): 237-243; and Marlin et al. (2010) Biochem Biophys Res Commun 394: 737-742.

Otoacoustic emissions from DFNB9 patients are normal, at least for the first decade of life, indicating morphological integrity of the inner ear and proper function of outer hair cells. Apart from the lack of synaptic transmission and the subsequent loss of synapses, the morphology and physiology of the inner ear remains preserved in DFNB9, at least during the first decade in life in humans.

Studies in mouse models revealed that synapses are structurally normal, and IHCs preserve normal synapse numbers in mice within the first postnatal week. Between P6 and P15, about half of the synapses get lost (Roux et al. (2006) Cell 127 277-289). Animal models allowed studying the effect of mutations in otoferlin on synaptic transmission by recording the change in plasma membrane capacitance after vesicle fusion and the activity in the auditory nerve. In otoferlin knock-out (Otof−/−) mice, almost no exocytosis could be triggered in IHCs by depolarization induced Ca2+ influx through voltage gated Ca2+ channels (Roux et al. (2006) Cell 127 277-289). In profoundly hearing impaired pachanga (Otof^Pga/Pga) mice with a random point mutation in the C2F domain, short (<10 ms) depolarizations of the IHCs elicited vesicle fusion of similar size as in wild type mice, however sustained stimulations uncovered a strong deficiency in replenishing vesicles to the readily releasable pool (Pangrsic et al. (2010) Nat. Neurosci. 13 869-876). The p.Ile515Thr mutation, found in human patients with only mildly elevated hearing thresholds but a severe reduction in speech understanding and a temperature-dependent deafening (Varga et al. (2006) J Med Genet 43 576-581), uncovered an intermediate phenotype when studied in a mouse model (Strenzke et al. (2016) EMBO J. 35:2519-2535). These OtofI515T/I515T mice showed a moderate elevation of hearing thresholds when assessed by ABR with a reduction in wave I amplitude, but normal auditory thresholds in behavioral tests and recordings of single auditory nerve units. Exocytosis of the RRP is again intact, but sustained exocytosis is reduced, although not as severe as in OtofPga/Pga. While in wild type mice at room temperature, during a sustained stimulus 750 vesicles can fuse per second at each active zone, this rate drops to 350 vesicles/s/active zone in OtofI515T/I515T mice and to 200 vesicles/s/active zone in OtofPga/Pga IHCs (Pangrsic et al. (2010) Nat. Neurosci. 13 869-876; Strenzke et al. (2016) EMBO J. 35 2519-2535). This correlated with lower otoferlin protein levels at the plasma membrane of IHCs, indicating that the amount of otoferlin scales with exocytosis and hearing (Strenzke et al. (2016) EMBO J. 35 2519-2535).

Methods of detecting mutations in a gene are well-known in the art. Non-limiting examples of such techniques include: real-time polymerase chain reaction (RT-PCR), PCR, sequencing, Southern blotting, and Northern blotting.

The OTOF gene encodes otoferlin, a protein that is involved in synaptic vesicle exocytosis in cochlear hair cells (see, e.g., Johnson and Chapman (2010) J. Cell Biol. 191(1):187-198; and Heidrych et al. (2008) Hum. Mol. Genet. 17:3814-3821).

The human OTOF gene is located on chromosome 2p23.3. It contains 48 exons encompassing ˜132 kilobases (kb) (NCBI Accession No. NG009937.1). The mRNA encoding the long-form of otoferlin expressed in the brain includes 48 exons (Yasunaga et al., Am. J. Hum. Genet. 67:591-600, 2000). Forward and reverse primers that can be used to amplify each of the 48 exons in the OTOF gene are described in Table 2 of Yasunaga et al., Am. J. Hum. Genet. 67:591-600, 2000. In some examples, the full-length OTOF protein is a full-length wildtype OTOF protein. The full-length wildtype OTOF protein expressed from the human OTOF gene is 1997 residues in length.

An exemplary human wildtype otoferlin protein is or includes the sequence of any one of SEQ ID NOs: 8-12. Isoform e of human otoferlin protein (SEQ ID NO: 12) is encoded by an mRNA that includes exon 48 and does not include exon 47 of the otoferlin gene (Yasunaga et al., Am. J. Hum. Genet. 67:591-600, 2000). In some embodiments, the active otoferlin protein has the sequence of SEQ ID NO: 12, but is missing the 20 amino acids including the RXR motif identified in Strenzke et al., EMBO J. 35(23):2499-2615, 2016). Non-limiting examples of nucleic acids encoding a wildtype otoferlin protein are or include any one of SEQ ID NO: 13-17. As can be appreciated in the art, at least some or all of the codons in SEQ ID NO: 13-17 can be codon-optimized to allow for optimal expression in a non-human mammal or in a human. Orthologs of human otoferlin proteins are known in the art.

Human canonical (long) isoform sequence (otoferlin protein) (also

called otoferlin isoform a) (NCBI Accession No. AAD26117.1)

(SEQ ID NO: 8)

MIKTEKSYPERRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKR

HTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFSIVEEETGKDCAKVKTL

FLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEFLCGLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAF

QLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPI

IVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDPLAAFELLQIGPAGK

ADLPPINGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGVQSSLIH

NYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLRRFIYRPPDRSAPSWNTT

GEVVVTMEPEVPIKKLETMVKLDATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFAS

IDTMKEQLRQQEPSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKID

ELKVYPKELESEFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDST

YGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIE

ASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRL

CKDGKVDGPHFGPPGRVKVANRVFTGPSEIEDENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRP

LLNPDKPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIF

VRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTLQI

WDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVKGWWPLLARNENDEFEL

TGKVEAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDTSFIWFLNPLKSARYFLWHTYRWLLLKLLLLLL

LLLLLALFLYSVPGYLVKKILGA

Human Isoform 2 (short 1) (otoferlin protein) (also called otoferlin

isoform d) (NCBI Accession No. NP_919304.1)

(SEQ ID NO: 9)

MIKTEKSYPERRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKR

HTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFSIVEEETGKDCAKVKTL

FLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEFLCGLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAF

QLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPI

IVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGK

ADLPPINGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGVQSSLIH

NYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLRRFIYRPPDRSAPSWNTT

GEVVVTMEPEVPIKKLETMVKLDATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFAS

IDTMKEQLRQQEPSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKID

ELKVYPKELESEFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDST

YGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIE

ASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRL

CKDGKVDGPHFGPPGRVKVANRVFTGPSEIEDENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRP

LLNPDKPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIF

VRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTLQI

WDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVKGWWPLLARNENDEFEL

TGKVEAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDTAFVWFLNPLKSIKYLICTRYKWLIIKIVLALL

GLLMLGLFLYSLPGYMVKKLLGA

Human Isoform 3 (short 2) (otoferlin protein) (also called otoferlin

isoform c) (NCBI Accession No. NP_919303.1)

(SEQ ID NO: 10)

MMTDTQDGPSESSQIMRSLTPLINREEAFGEAGEAGLWPSITHTPDSQEEGLNDIQEMIKTEKSYPERRLR

GVLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDKLRLCQNFL

QKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFSIVEEETGKDCAKVKTLFLKLPGKRGFGSAG

WTVQAKVELYLWLGLSKQRKEFLCGLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSLFA

ADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVETNLELYGEAHELRDDPPIIVIEIYDQDSMGKA

DFMGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGKADLPPINGPVDVDR

GPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGVQSSLIHNYKKNPNFNTLVKW

FEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLRRFIYRPPDRSAPSWNTTVALLARCRVLCNGG

SSSHSTGEVVVTMEPEVPIKKLETMVKLDATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWW

SKYFASIDTMKEQLRQQEPSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEK

KKPKIDELKVYPKELESEFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSRE

AGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFG

KSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHGYNIWRDPMKPS

QILTRLCKDGKVDGPHFGPPGRVKVANRVFTGPSEIEDENGQRKPTDEHVALLALRHWEDIPRAGCRLVPE

HVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGE

KSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPA

RLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVKGWWPLLARNE

NDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDTSFIWFLNPLKSARYFLWHTYRWLLLK

LLLLLLLLLLLALFLYSVPGYLVKKILGA

Human Isoform 4 (short 3) (otoferlin protein) (also called otoferlin

isoform b) (NCBI Accession No. NP_004793.2)

(SEQ ID NO: 11)

MIKTEKSYPERRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKR

HTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFSIVEEETGKDCAKVKTL

FLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEFLCGLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAF

QLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPI

IVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGK

ADLPPINGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGVQSSLIH

NYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLRRFIYRPPDRSAPSWNTT

GEVVVTMEPEVPIKKLETMVKLDATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFAS

IDTMKEQLRQQEPSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKID

ELKVYPKELESEFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDST

YGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIE

ASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRL

CKDGKVDGPHFGPPGRVKVANRVFTGPSEIEDENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRP

LLNPDKPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIF

VRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTLQI

WDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVKGWWPLLARNENDEFEL

TGKVEAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDTSFIWFLNPLKSARYFLWHTYRWLLLKLLLLLL

LLLLLALFLYSVPGYLVKKILGA

Human Isoform 5 (short 4) (otoferlin protein) (also called otoferlin

isoform e) (NCBI Accession No. NP_001274418.1)

(SEQ ID NO: 12)

MALLIHLKTVSELRGRGDRIAKVTFRGQSFYSRVLENCEDVADFDETFRWPVASSIDRNEMLEIQVFNYSK

VFSNKLIGTFRMVLQKVVEESHVEVTDTLIDDNNAIIKTSLCVEVRYQATDGTVGSWDDGDFLGDESLQEE

EKDSQETDGLLPGSRPSSRPPGEKSFRRAGRSVFSAMKLGKNRSHKEEPQRPDEPAVLEMEDLDHLAIRLG

DGLDPDSVSLASVTALTTNVSNKRSKPDIKMEPSAGRPMDYQVSITVIEARQLVGLNMDPVVCVEVGDDKK

YTSMKESTNCPYYNEYFVFDFHVSPDVMFDKIIKISVIHSKNLLRSGTLVGSFKMDVGTVYSQPEHQFHHK

WAILSDPDDISSGLKGYVKCDVAVVGKGDNIKTPHKANETDEDDIEGNLLLPEGVPPERQWARFYVKIYRA

EGLPRMNTSLMANVKKAFIGENKDLVDPYVQVFFAGQKGKTSVQKSSYEPLWNEQVVFTDLFPPLCKRMKV

QIRDSDKVNDVAIGTHFIDLRKISNDGDKGFLPTLGPAWVNMYGSTRNYTLLDEHQDLNEGLGEGVSFRAR

LLLGLAVEIVDTSNPELTSSTEVQVEQATPISESCAGKMEEFFLFGAFLEASMIDRRNGDKPITFEVTIGN

YGNEVDGLSRPQRPRPRKEPGDEEEVDLIQNASDDEAGDAGDLASVSSTPPMRPQVTDRNYFHLPYLERKP

CIYIKSWWPDQRRRLYNANIMDHIADKLEEGLNDIQEMIKTEKSYPERRLRGVLEELSCGCCRFLSLADKD

QGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIW

MMSNNKRVAYARVPSKDLLFSIVEEETGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRK

EFLCGLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQ

CTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYC

PPRFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGKADLPPINGPVDVDRGPIMPVPMGIRPVLSKYRVE

VLFWGLRDLKRVNLAQVDRPRVDIECAGKGVQSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVV

DCRAFGRYTLVGSHAVSSLRRFIYRPPDRSAPSWNTTVRLLRRCRVLCNGGSSSHSTGEVVVTMEPEVPIK

KLETMVKLDATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQEPS

GIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDELKVYPKELESEFD

NFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDSTYGMFQGIPSNDPIN

VLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVY

DWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPP

GRVKVANRVFTGPSEIEDENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRL

ELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQD

TDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTLQIWDADHFSADDFLGA

IELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVKGWWPLLARNENDEFELTGKVEAELHLLTAE

EAEKNPVGLARNEPDPLEKPNRPDTAFVWFLNPLKSIKYLICTRYKWLIIKIVLALLGLLMLGLFLYSLPG

YMVKKLLGA

Complete cds (otoferlin cDNA) (encodes the protein of SEQ ID NO: 8)

(SEQ ID NO: 13)

atga tcaaaacgga gaagtcctac cctgagcgtc gcctgcgggg cgtcctggag gagctgagct

gtggctgctg ccgcttcctc tccctcgctg acaaggacca gggccactca tcccgcacca

ggcttgaccg ggagcgcctc aagtcctgca tgagggagct ggaaaacatg gggcagcagg

ccaggatgct gcgggcccag gtgaagcggc acacggtgcg ggacaagctg aggctgtgcc

agaacttcct gcagaagctg cgcttcctgg cggacgagcc ccagcacagc attcccgaca

tcttcatctg gatgatgagc aacaacaagc gtgtcgccta tgcccgtgtg ccctccaagg

acctgctctt ctccatcgtg gaggaggaga ctggcaagga ctgcgccaag gtcaagacgc

tcttccttaa gctgccaggg aagcggggct tcggctcggc aggctggaca gtgcaggcca

aggtggagct gtacctgtgg ctgggcctca gcaaacagcg caaggagttc ctgtgcggcc

tgccctgtgg cttccaggag gtcaaggcag cccagggcct gggcctgcat gccttcccac

ccgtcagcct ggtctacacc aagaagcagg cgttccagct ccgagcgcac atgtaccagg

cccgcagcct ctttgccgcc gacagcagcg gactctcaga cccctttgcc cgcgtcttct

tcatcaatca gagtcagtgc acagaggtgc tgaatgagac cctgtgtccc acctgggacc

agatgctggt gttcgacaac ctggagctct atggtgaagc tcatgagctg agggacgatc

cgcccatcat tgtcattgaa atctatgacc aggattccat gggcaaagct gacttcatgg

gccggacctt cgccaaaccc ctggtgaaga tggcagacga ggcgtactgc ccaccccgct

tcccacctca gctcgagtac taccagatct accgtggcaa cgccacagct ggagacccgc

tggcggcctt cgagctgctg cagattggac cagcagggaa ggctgacctg ccccccatca

atggcccggt ggacgtggac cgaggtccca tcatgcccgt gcccatgggc atccggcccg

tgctcagcaa gtaccgagtg gaggtgctgt tctggggcct acgggaccta aagcgggtga

acctggccca ggtggaccgg ccacgggtgg acatcgagtg tgcagggaag ggggtgcagt

cgtccctgat ccacaattat aagaagaacc ccaacttcaa caccctcgtc aagtggtttg

aagtggacct cccagagaac gagctgctgc acccgccctt gaacatccgt gtggtggact

gccgggcctt cggtcgctac acactggtgg gctcccatgc cgtcagctcc ctgcgacgct

tcatctaccg gcccccagac cgctcggccc ccagctggaa caccacgggg gaggttgtgg

tgactatgga gccagaggta cccatcaaga aactggagac catggtgaag ctggacgcga

cttctgaagc tgttgtcaag gtggatgtgg ctgaggagga gaaggagaag aagaagaaga

agaagggcac tgcggaggag ccagaggagg aggagccaga cgagagcatg ctggactggt

ggtccaagta ctttgcctcc attgacacca tgaaggagca acttcgacaa caagagccct

ctggaattga cttggaggag aaggaggaag tggacaatac cgagggcctg aaggggtcaa

tgaagggcaa ggagaaggca agggctgcca aagaggagaa gaagaagaaa actcagagct

ctggctctgg ccaggggtcc gaggcccccg agaagaagaa acccaagatt gatgagctta

aggtataccc caaagagctg gagtccgagt ttgataactt tgaggactgg ctgcacactt

tcaacttgct tcggggcaag accggggatg atgaggatgg ctccaccgag gaggagcgca

ttgtgggacg cttcaagggc tccctctgcg tgtacaaagt gccactccca gaggacgtgt

cccgggaagc cggctacgac tccacctacg gcatgttcca gggcatcccg agcaatgacc

ccatcaatgt gctggtccga gtctatgtgg tccgggccac ggacctgcac cctgctgaca

tcaacggcaa agctgacccc tacatcgcca tccggctagg caagactgac atccgcgaca

aggagaacta catctccaag cagctcaacc ctgtctttgg gaagtccttt gacatcgagg

cctccttccc catggaatcc atgctgacgg tggctgtgta tgactgggac ctggtgggca

ctgatgacct cattggggaa accaagatcg acctggagaa ccgcttctac agcaagcacc

gcgccacctg cggcatcgcc cagacctact ccacacatgg ctacaatatc tggcgggacc

ccatgaagcc cagccagatc ctgacccgcc tctgcaaaga cggcaaagtg gacggccccc

actttgggcc ccctgggaga gtgaaggtgg ccaaccgcgt cttcactggg ccctctgaga

ttgaggacga gaacggtcag aggaagccca cagacgagca tgtggcgctg ttggccctga

ggcactggga ggacatcccc cgcgcaggct gccgcctggt gccagagcat gtggagacga

ggccgctgct caaccccgac aagccgggca tcgagcaggg ccgcctggag ctgtgggtgg

acatgttccc catggacatg ccagcccctg ggacgcctct ggacatctca cctcggaagc

ccaagaagta cgagctgcgg gtcatcatct ggaacacaga tgaggtggtc ttggaggacg

acgacttctt cacaggggag aagtccagtg acatcttcgt gagggggtgg ctgaagggcc

agcaggagga caagcaggac acagacgtcc actaccactc cctcactggc gagggcaact

tcaactggcg ctacctgttc cccttcgact acctggcggc ggaggagaag atcgtcatct

ccaagaagga gtccatgttc tcctgggacg agaccgagta caagatcccc gcgcggctca

ccctgcagat ctgggatgcg gaccacttct ccgctgacga cttcctgggg gccatcgagc

tggacctgaa ccggttcccg cggggcgcaa agacagccaa gcagtgcacc atggagatgg

ccaccgggga ggtggacgtg cccctcgtgt ccatcttcaa gcaaaagcgc gtcaaaggct

ggtggcccct cctggcccgc aatgagaacg atgagtttga gctcacgggc aaggtggagg

ctgagctgca tttactgaca gcagaggagg cagagaagaa cccagtgggc ctggcccgca

atgaacctga ccccctagag aaacccaacc ggcccgacac gagcttcatc tggttcctga

accctctcaa gtcggctcgc tacttcttgt ggcacacgta tcgctggctg ctcctcaaac

tgttgctgct cctgctgctg ctcctcctcc tcgccctgtt cctctactct gtgcctggct

acctggtcaa gaaaatcctc ggggcctga

Human Otoferlin Transcript Variant 1 (encodes the protein of SEQ ID NO: 8)

(SEQ ID NO: 14)

atggccttgctca tccacctcaa gacagtctcg gagctgcggg gcaggggcga ccggatcgcc

aaagtgactt tccgagggca atccttctac tctcgggtcc tggagaactg tgaggatgtg

gctgactttg atgagacatt tcggtggccg gtggccagca gcatcgacag aaatgagatg

ctggagattc aggttttcaa ctacagcaaa gtcttcagca acaagctcat cgggaccttc

cgcatggtgc tgcagaaggt ggtagaggag agccatgtgg aggtgactga cacgctgatt

gatgacaaca atgctatcat caagaccagc ctgtgcgtgg aggtccggta tcaggccact

gacggcacag tgggctcctg ggacgatggg gacttcctgg gagatgagtc tcttcaagag

gaagagaagg acagccaaga gacggatgga ctgctcccag gctcccggcc cagctcccgg

cccccaggag agaagagctt ccggagagcc gggaggagcg tgttctccgc catgaagctc

ggcaaaaacc ggtctcacaa ggaggagccc caaagaccag atgaaccggc ggtgctggag

atggaagacc ttgaccatct ggccattcgg ctaggagatg gactggatcc cgactcggtg

tctctagcct cagtcacagc tctcaccact aatgtctcca acaagcgatc taagccagac

attaagatgg agccaagtgc tgggcggccc atggattacc aggtcagcat cacggtgatc

gaggcccggc agctggtggg cttgaacatg gaccctgtgg tgtgcgtgga ggtgggtgac

gacaagaagt acacatccat gaaggagtcc actaactgcc cctattacaa cgagtacttc

gtcttcgact tccatgtctc tccggatgtc atgtttgaca agatcatcaa gatttcggtg

attcactcca agaacctgct gcgcagtggc accctggtgg gctccttcaa aatggacgtg

ggaaccgtgt actcgcagcc agagcaccag ttccatcaca agtgggccat cctgtctgac

cccgatgaca tctcctcggg gctgaagggc tacgtgaagt gtgacgttgc cgtggtgggc

aaaggggaca acatcaagac gccccacaag gccaatgaga ccgacgaaga tgacattgag

gggaacttgc tgctccccga gggggtgccc cccgaacgcc agtgggcccg gttctatgtg

aaaatttacc gagcagaggg gctgccccgt atgaacacaa gcctcatggc caatgtaaag

aaggctttca tcggtgaaaa caaggacctc gtggacccct acgtgcaagt cttctttgct

ggccagaagg gcaagacttc agtgcagaag agcagctatg agcccctgtg gaatgagcag

gtcgtcttta cagacctctt ccccccactc tgcaaacgca tgaaggtgca gatccgagac

tcggacaagg tcaacgacgt ggccatcggc acccacttca ttgacctgcg caagatttct

aatgacggag acaaaggctt cctgcccaca ctgggcccag cctgggtgaa catgtacggc

tccacacgta actacacgct gctggatgag catcaggacc tgaacgaggg cctgggggag

ggtgtgtcct tccgggcccg gctcctgctg ggcctggctg tggagatcgt agacacctcc

aaccctgagc tcaccagctc cacagaggtg caggtggagc aggccacgcc catctcggag

agctgtgcag gtaaaatgga agaattcttt ctctttggag ccttcctgga ggcctcaatg

atcgaccgga gaaacggaga caagcccatc acctttgagg tcaccatagg caactatggg

aacgaagttg atggcctgtc ccggccccag cggcctcggc cccggaagga gccgggggat

gaggaagaag tagacctgat tcagaacgca agtgatgacg aggccggtga tgccggggac

ctggcctcag tctcctccac tccaccaatg cggccccagg tcaccgacag gaactacttc

catctgccct acctggagcg aaagccctgc atctacatca agagctggtg gccggaccag

cgccgccgcc tctacaatgc caacatcatg gaccacattg ccgacaagct ggaagaaggc

ctgaacgaca tacaggagat gatcaaaacg gagaagtcct accctgagcg tcgcctgcgg

ggcgtcctgg aggagctgag ctgtggctgc tgccgcttcc tctccctcgc tgacaaggac

cagggccact catcccgcac caggcttgac cgggagcgcc tcaagtcctg catgagggag

ctggaaaaca tggggcagca ggccaggatg ctgcgggccc aggtgaagcg gcacacggtg

cgggacaagc tgaggctgtg ccagaacttc ctgcagaagc tgcgcttcct ggcggacgag

ccccagcaca gcattcccga catcttcatc tggatgatga gcaacaacaa gcgtgtcgcc

tatgcccgtg tgccctccaa ggacctgctc ttctccatcg tggaggagga gactggcaag

gactgcgcca aggtcaagac gctcttcctt aagctgccag ggaagcgggg cttcggctcg

gcaggctgga cagtgcaggc caaggtggag ctgtacctgt ggctgggcct cagcaaacag

cgcaaggagt tcctgtgcgg cctgccctgt ggcttccagg aggtcaaggc agcccagggc

ctgggcctgc atgccttccc acccgtcagc ctggtctaca ccaagaagca ggcgttccag

ctccgagcgc acatgtacca ggcccgcagc ctctttgccg ccgacagcag cggactctca

gacccctttg cccgcgtctt cttcatcaat cagagtcagt gcacagaggt gctgaatgag

accctgtgtc ccacctggga ccagatgctg gtgttcgaca acctggagct ctatggtgaa

gctcatgagc tgagggacga tccgcccatc attgtcattg aaatctatga ccaggattcc

atgggcaaag ctgacttcat gggccggacc ttcgccaaac ccctggtgaa gatggcagac

gaggcgtact gcccaccccg cttcccacct cagctcgagt actaccagat ctaccgtggc

aacgccacag ctggagacct gctggcggcc ttcgagctgc tgcagattgg accagcaggg

aaggctgacc tgccccccat caatggcccg gtggacgtgg accgaggtcc catcatgccc

gtgcccatgg gcatccggcc cgtgctcagc aagtaccgag tggaggtgct gttctggggc

ctacgggacc taaagcgggt gaacctggcc caggtggacc ggccacgggt ggacatcgag

tgtgcaggga agggggtgca gtcgtccctg atccacaatt ataagaagaa ccccaacttc

aacaccctcg tcaagtggtt tgaagtggac ctcccagaga acgagctgct gcacccgccc

ttgaacatcc gtgtggtgga ctgccgggcc ttcggtcgct acacactggt gggctcccat

gccgtcagct ccctgcgacg cttcatctac cggcccccag accgctcggc ccccagctgg

aacaccacgg tcaggcttct ccggcgctgc cgtgtgctgt gcaatggggg ctcctcctct

cactccacag gggaggttgt ggtgactatg gagccagagg tacccatcaa gaaactggag

accatggtga agctggacgc gacttctgaa gctgttgtca aggtggatgt ggctgaggag

gagaaggaga agaagaagaa gaagaagggc actgcggagg agccagagga ggaggagcca

gacgagagca tgctggactg gtggtccaag tactttgcct ccattgacac catgaaggag

caacttcgac aacaagagcc ctctggaatt gacttggagg agaaggagga agtggacaat

accgagggcc tgaaggggtc aatgaagggc aaggagaagg caagggctgc caaagaggag

aagaagaaga aaactcagag ctctggctct ggccaggggt ccgaggcccc cgagaagaag

aaacccaaga ttgatgagct taaggtatac cccaaagagc tggagtccga gtttgataac

tttgaggact ggctgcacac tttcaacttg cttcggggca agaccgggga tgatgaggat

ggctccaccg aggaggagcg cattgtggga cgcttcaagg gctccctctg cgtgtacaaa

gtgccactcc cagaggacgt gtcccgggaa gccggctacg actccaccta cggcatgttc

cagggcatcc cgagcaatga ccccatcaat gtgctggtcc gagtctatgt ggtccgggcc

acggacctgc accctgctga catcaacggc aaagctgacc cctacatcgc catccggcta

ggcaagactg acatccgcga caaggagaac tacatctcca agcagctcaa ccctgtcttt

gggaagtcct ttgacatcga ggcctccttc cccatggaat ccatgctgac ggtggctgtg

tatgactggg acctggtggg cactgatgac ctcattgggg aaaccaagat cgacctggag

aaccgcttct acagcaagca ccgcgccacc tgcggcatcg cccagaccta ctccacacat

ggctacaata tctggcggga ccccatgaag cccagccaga tcctgacccg cctctgcaaa

gacggcaaag tggacggccc ccactttggg ccccctggga gagtgaaggt ggccaaccgc

gtcttcactg ggccctctga gattgaggac gagaacggtc agaggaagcc cacagacgag

catgtggcgc tgttggccct gaggcactgg gaggacatcc cccgcgcagg ctgccgcctg

gtgccagagc atgtggagac gaggccgctg ctcaaccccg acaagccggg catcgagcag

ggccgcctgg agctgtgggt ggacatgttc cccatggaca tgccagcccc tgggacgcct

ctggacatct cacctcggaa gcccaagaag tacgagctgc gggtcatcat ctggaacaca

gatgaggtgg tcttggagga cgacgacttc ttcacagggg agaagtccag tgacatcttc

gtgagggggt ggctgaaggg ccagcaggag gacaagcagg acacagacgt ccactaccac

tccctcactg gcgagggcaa cttcaactgg cgctacctgt tccccttcga ctacctggcg

gcggaggaga agatcgtcat ctccaagaag gagtccatgt tctcctggga cgagaccgag

tacaagatcc ccgcgcggct caccctgcag atctgggatg cggaccactt ctccgctgac

gacttcctgg gggccatcga gctggacctg aaccggttcc cgcggggcgc aaagacagcc

aagcagtgca ccatggagat ggccaccggg gaggtggacg tgcccctcgt gtccatcttc

aagcaaaagc gcgtcaaagg ctggtggccc ctcctggccc gcaatgagaa cgatgagttt

gagctcacgg gcaaggtgga ggctgagctg catttactga cagcagagga ggcagagaag

aacccagtgg gcctggcccg caatgaacct gaccccctag agaaacccaa ccggcccgac

acgagcttca tctggttcct gaaccctctc aagtcggctc gctacttctt gtggcacacg

tatcgctggc tgctcctcaa actgttgctg ctcctgctgc tgctcctcct cctcgccctg

ttcctctact ctgtgcctgg ctacctggtc aagaaaatcc tcggggcctg a

Human Otoferlin Transcript Variant 2 (encodes the protein of SEQ ID NO: 11)

(SEQ ID NO: 15)

atgatcaaaacgga gaagtcctac cctgagcgtc gcctgcgggg cgtcctggag gagctgagct

gtggctgctg ccgcttcctc tccctcgctg acaaggacca gggccactca tcccgcacca

ggcttgaccg ggagcgcctc aagtcctgca tgagggagct ggaaaacatg gggcagcagg

ccaggatgct gcgggcccag gtgaagcggc acacggtgcg ggacaagctg aggctgtgcc

agaacttcct gcagaagctg cgcttcctgg cggacgagcc ccagcacagc attcccgaca

tcttcatctg gatgatgagc aacaacaagc gtgtcgccta tgcccgtgtg ccctccaagg

acctgctctt ctccatcgtg gaggaggaga ctggcaagga ctgcgccaag gtcaagacgc

tcttccttaa gctgccaggg aagcggggct tcggctcggc aggctggaca gtgcaggcca

aggtggagct gtacctgtgg ctgggcctca gcaaacagcg caaggagttc ctgtgcggcc

tgccctgtgg cttccaggag gtcaaggcag cccagggcct gggcctgcat gccttcccac

ccgtcagcct ggtctacacc aagaagcagg cgttccagct ccgagcgcac atgtaccagg

cccgcagcct ctttgccgcc gacagcagcg gactctcaga cccctttgcc cgcgtcttct

tcatcaatca gagtcagtgc acagaggtgc tgaatgagac cctgtgtccc acctgggacc

agatgctggt gttcgacaac ctggagctct atggtgaagc tcatgagctg agggacgatc

cgcccatcat tgtcattgaa atctatgacc aggattccat gggcaaagct gacttcatgg

gccggacctt cgccaaaccc ctggtgaaga tggcagacga ggcgtactgc ccaccccgct

tcccacctca gctcgagtac taccagatct accgtggcaa cgccacagct ggagacctgc

tggcggcctt cgagctgctg cagattggac cagcagggaa ggctgacctg ccccccatca

atggcccggt ggacgtggac cgaggtccca tcatgcccgt gcccatgggc atccggcccg

tgctcagcaa gtaccgagtg gaggtgctgt tctggggcct acgggaccta aagcgggtga

acctggccca ggtggaccgg ccacgggtgg acatcgagtg tgcagggaag ggggtgcagt

cgtccctgat ccacaattat aagaagaacc ccaacttcaa caccctcgtc aagtggtttg

aagtggacct cccagagaac gagctgctgc acccgccctt gaacatccgt gtggtggact

gccgggcctt cggtcgctac acactggtgg gctcccatgc cgtcagctcc ctgcgacgct

tcatctaccg gcccccagac cgctcggccc ccagctggaa caccacgggg gaggttgtgg

tgactatgga gccagaggta cccatcaaga aactggagac catggtgaag ctggacgcga

cttctgaagc tgttgtcaag gtggatgtgg ctgaggagga gaaggagaag aagaagaaga

agaagggcac tgcggaggag ccagaggagg aggagccaga cgagagcatg ctggactggt

ggtccaagta ctttgcctcc attgacacca tgaaggagca acttcgacaa caagagccct

ctggaattga cttggaggag aaggaggaag tggacaatac cgagggcctg aaggggtcaa

tgaagggcaa ggagaaggca agggctgcca aagaggagaa gaagaagaaa actcagagct

ctggctctgg ccaggggtcc gaggcccccg agaagaagaa acccaagatt gatgagctta

aggtataccc caaagagctg gagtccgagt ttgataactt tgaggactgg ctgcacactt

tcaacttgct tcggggcaag accggggatg atgaggatgg ctccaccgag gaggagcgca

ttgtgggacg cttcaagggc tccctctgcg tgtacaaagt gccactccca gaggacgtgt

cccgggaagc cggctacgac tccacctacg gcatgttcca gggcatcccg agcaatgacc

ccatcaatgt gctggtccga gtctatgtgg tccgggccac ggacctgcac cctgctgaca

tcaacggcaa agctgacccc tacatcgcca tccggctagg caagactgac atccgcgaca

aggagaacta catctccaag cagctcaacc ctgtctttgg gaagtccttt gacatcgagg

cctccttccc catggaatcc atgctgacgg tggctgtgta tgactgggac ctggtgggca

ctgatgacct cattggggaa accaagatcg acctggagaa ccgcttctac agcaagcacc

gcgccacctg cggcatcgcc cagacctact ccacacatgg ctacaatatc tggcgggacc

ccatgaagcc cagccagatc ctgacccgcc tctgcaaaga cggcaaagtg gacggccccc

actttgggcc ccctgggaga gtgaaggtgg ccaaccgcgt cttcactggg ccctctgaga

ttgaggacga gaacggtcag aggaagccca cagacgagca tgtggcgctg ttggccctga

ggcactggga ggacatcccc cgcgcaggct gccgcctggt gccagagcat gtggagacga

ggccgctgct caaccccgac aagccgggca tcgagcaggg ccgcctggag ctgtgggtgg

acatgttccc catggacatg ccagcccctg ggacgcctct ggacatctca cctcggaagc

ccaagaagta cgagctgcgg gtcatcatct ggaacacaga tgaggtggtc ttggaggacg

acgacttctt cacaggggag aagtccagtg acatcttcgt gagggggtgg ctgaagggcc

agcaggagga caagcaggac acagacgtcc actaccactc cctcactggc gagggcaact

tcaactggcg ctacctgttc cccttcgact acctggcggc ggaggagaag atcgtcatct

ccaagaagga gtccatgttc tcctgggacg agaccgagta caagatcccc gcgcggctca

ccctgcagat ctgggatgcg gaccacttct ccgctgacga cttcctgggg gccatcgagc

tggacctgaa ccggttcccg cggggcgcaa agacagccaa gcagtgcacc atggagatgg

ccaccgggga ggtggacgtg cccctcgtgt ccatcttcaa gcaaaagcgc gtcaaaggct

ggtggcccct cctggcccgc aatgagaacg atgagtttga gctcacgggc aaggtggagg

ctgagctgca tttactgaca gcagaggagg cagagaagaa cccagtgggc ctggcccgca

atgaacctga ccccctagag aaacccaacc ggcccgacac gagcttcatc tggttcctga

accctctcaa gtcggctcgc tacttcttgt ggcacacgta tcgctggctg ctcctcaaac

tgttgctgct cctgctgctg ctcctcctcc tcgccctgtt cctctactct gtgcctggct

acctggtcaa gaaaatcctc ggggcctga

Human Otoferlin Transcript Variant 3 (encodes the protein of SEQ ID NO: 8)

(SEQ ID NO: 16)

atgatgaccga tactcaggat ggccctagcg agagctccca gatcatgagg tccctcactc

ccctgatcaa cagggaggag gcatttgggg aggctgggga ggcggggctg tggcccagca

tcacccacac tcctgattca caggaagaag gcctgaacga catacaggag atgatcaaaa

cggagaagtc ctaccctgag cgtcgcctgc ggggcgtcct ggaggagctg agctgtggct

gctgccgctt cctctccctc gctgacaagg accagggcca ctcatcccgc accaggcttg

accgggagcg cctcaagtcc tgcatgaggg agctggaaaa catggggcag caggccagga

tgctgcgggc ccaggtgaag cggcacacgg tgcgggacaa gctgaggctg tgccagaact

tcctgcagaa gctgcgcttc ctggcggacg agccccagca cagcattccc gacatcttca

tctggatgat gagcaacaac aagcgtgtcg cctatgcccg tgtgccctcc aaggacctgc

tcttctccat cgtggaggag gagactggca aggactgcgc caaggtcaag acgctcttcc

ttaagctgcc agggaagcgg ggcttcggct cggcaggctg gacagtgcag gccaaggtgg

agctgtacct gtggctgggc ctcagcaaac agcgcaagga gttcctgtgc ggcctgccct

gtggcttcca ggaggtcaag gcagcccagg gcctgggcct gcatgccttc ccacccgtca

gcctggtcta caccaagaag caggcgttcc agctccgagc gcacatgtac caggcccgca

gcctctttgc cgccgacagc agcggactct cagacccctt tgcccgcgtc ttcttcatca

atcagagtca gtgcacagag gtgctgaatg agaccctgtg tcccacctgg gaccagatgc

tggtgttcga caacctggag ctctatggtg aagctcatga gctgagggac gatccgccca

tcattgtcat tgaaatctat gaccaggatt ccatgggcaa agctgacttc atgggccgga

ccttcgccaa acccctggtg aagatggcag acgaggcgta ctgcccaccc cgcttcccac

ctcagctcga gtactaccag atctaccgtg gcaacgccac agctggagac ctgctggcgg

ccttcgagct gctgcagatt ggaccagcag ggaaggctga cctgcccccc atcaatggcc

cggtggacgt ggaccgaggt cccatcatgc ccgtgcccat gggcatccgg cccgtgctca

gcaagtaccg agtggaggtg ctgttctggg gcctacggga cctaaagcgg gtgaacctgg

cccaggtgga ccggccacgg gtggacatcg agtgtgcagg gaagggggtg cagtcgtccc

tgatccacaa ttataagaag aaccccaact tcaacaccct cgtcaagtgg tttgaagtgg

acctcccaga gaacgagctg ctgcacccgc ccttgaacat ccgtgtggtg gactgccggg

ccttcggtcg ctacacactg gtgggctccc atgccgtcag ctccctgcga cgcttcatct

accggccccc agaccgctcg gcccccagct ggaacaccac ggtcaggctt ctccggcgct

gccgtgtgct gtgcaatggg ggctcctcct ctcactccac aggggaggtt gtggtgacta

tggagccaga ggtacccatc aagaaactgg agaccatggt gaagctggac gcgacttctg

aagctgttgt caaggtggat gtggctgagg aggagaagga gaagaagaag aagaagaagg

gcactgcgga ggagccagag gaggaggagc cagacgagag catgctggac tggtggtcca

agtactttgc ctccattgac accatgaagg agcaacttcg acaacaagag ccctctggaa

ttgacttgga ggagaaggag gaagtggaca ataccgaggg cctgaagggg tcaatgaagg

gcaaggagaa ggcaagggct gccaaagagg agaagaagaa gaaaactcag agctctggct

ctggccaggg gtccgaggcc cccgagaaga agaaacccaa gattgatgag cttaaggtat

accccaaaga gctggagtcc gagtttgata actttgagga ctggctgcac actttcaact

tgcttcgggg caagaccggg gatgatgagg atggctccac cgaggaggag cgcattgtgg

gacgcttcaa gggctccctc tgcgtgtaca aagtgccact cccagaggac gtgtcccggg

aagccggcta cgactccacc tacggcatgt tccagggcat cccgagcaat gaccccatca

atgtgctggt ccgagtctat gtggtccggg ccacggacct gcaccctgct gacatcaacg

gcaaagctga cccctacatc gccatccggc taggcaagac tgacatccgc gacaaggaga

actacatctc caagcagctc aaccctgtct ttgggaagtc ctttgacatc gaggcctcct

tccccatgga atccatgctg acggtggctg tgtatgactg ggacctggtg ggcactgatg

acctcattgg ggaaaccaag atcgacctgg agaaccgctt ctacagcaag caccgcgcca

cctgcggcat cgcccagacc tactccacac atggctacaa tatctggcgg gaccccatga

agcccagcca gatcctgacc cgcctctgca aagacggcaa agtggacggc ccccactttg

ggccccctgg gagagtgaag gtggccaacc gcgtcttcac tgggccctct gagattgagg

acgagaacgg tcagaggaag cccacagacg agcatgtggc gctgttggcc ctgaggcact

gggaggacat cccccgcgca ggctgccgcc tggtgccaga gcatgtggag acgaggccgc

tgctcaaccc cgacaagccg ggcatcgagc agggccgcct ggagctgtgg gtggacatgt

tccccatgga catgccagcc cctgggacgc ctctggacat ctcacctcgg aagcccaaga

agtacgagct gcgggtcatc atctggaaca cagatgaggt ggtcttggag gacgacgact

tcttcacagg ggagaagtcc agtgacatct tcgtgagggg gtggctgaag ggccagcagg

aggacaagca ggacacagac gtccactacc actccctcac tggcgagggc aacttcaact

ggcgctacct gttccccttc gactacctgg cggcggagga gaagatcgtc atctccaaga

aggagtccat gttctcctgg gacgagaccg agtacaagat ccccgcgcgg ctcaccctgc

agatctggga tgcggaccac ttctccgctg acgacttcct gggggccatc gagctggacc

tgaaccggtt cccgcggggc gcaaagacag ccaagcagtg caccatggag atggccaccg

gggaggtgga cgtgcccctc gtgtccatct tcaagcaaaa gcgcgtcaaa ggctggtggc

ccctcctggc ccgcaatgag aacgatgagt ttgagctcac gggcaaggtg gaggctgagc

tgcatttact gacagcagag gaggcagaga agaacccagt gggcctggcc cgcaatgaac

ctgaccccct agagaaaccc aaccggcccg acacgagctt catctggttc ctgaaccctc

tcaagtcggc tcgctacttc ttgtggcaca cgtatcgctg gctgctcctc aaactgttgc

tgctcctgct gctgctcctc ctcctcgccc tgttcctcta ctctgtgcct ggctacctgg

tcaagaaaat cctcggggcc tga

Human Otoferlin Transcript Variant 4 (encodes the protein of SEQ ID NO: 9)

(SEQ ID NO: 17)

atga tcaaaacgga gaagtcctac cctgagcgtc gcctgcgggg cgtcctggag gagctgagct

gtggctgctg ccgcttcctc tccctcgctg acaaggacca gggccactca tcccgcacca

ggcttgaccg ggagcgcctc aagtcctgca tgagggagct ggaaaacatg gggcagcagg

ccaggatgct gcgggcccag gtgaagcggc acacggtgcg ggacaagctg aggctgtgcc

agaacttcct gcagaagctg cgcttcctgg cggacgagcc ccagcacagc attcccgaca

tcttcatctg gatgatgagc aacaacaagc gtgtcgccta tgcccgtgtg ccctccaagg

acctgctctt ctccatcgtg gaggaggaga ctggcaagga ctgcgccaag gtcaagacgc

tcttccttaa gctgccaggg aagcggggct tcggctcggc aggctggaca gtgcaggcca

aggtggagct gtacctgtgg ctgggcctca gcaaacagcg caaggagttc ctgtgcggcc

tgccctgtgg cttccaggag gtcaaggcag cccagggcct gggcctgcat gccttcccac

ccgtcagcct ggtctacacc aagaagcagg cgttccagct ccgagcgcac atgtaccagg

cccgcagcct ctttgccgcc gacagcagcg gactctcaga cccctttgcc cgcgtcttct

tcatcaatca gagtcagtgc acagaggtgc tgaatgagac cctgtgtccc acctgggacc

agatgctggt gttcgacaac ctggagctct atggtgaagc tcatgagctg agggacgatc

cgcccatcat tgtcattgaa atctatgacc aggattccat gggcaaagct gacttcatgg

gccggacctt cgccaaaccc ctggtgaaga tggcagacga ggcgtactgc ccaccccgct

tcccacctca gctcgagtac taccagatct accgtggcaa cgccacagct ggagacctgc

tggcggcctt cgagctgctg cagattggac cagcagggaa ggctgacctg ccccccatca

atggcccggt ggacgtggac cgaggtccca tcatgcccgt gcccatgggc atccggcccg

tgctcagcaa gtaccgagtg gaggtgctgt tctggggcct acgggaccta aagcgggtga

acctggccca ggtggaccgg ccacgggtgg acatcgagtg tgcagggaag ggggtgcagt

cgtccctgat ccacaattat aagaagaacc ccaacttcaa caccctcgtc aagtggtttg

aagtggacct cccagagaac gagctgctgc acccgccctt gaacatccgt gtggtggact

gccgggcctt cggtcgctac acactggtgg gctcccatgc cgtcagctcc ctgcgacgct

tcatctaccg gcccccagac cgctcggccc ccagctggaa caccacgggg gaggttgtgg

tgactatgga gccagaggta cccatcaaga aactggagac catggtgaag ctggacgcga

cttctgaagc tgttgtcaag gtggatgtgg ctgaggagga gaaggagaag aagaagaaga

agaagggcac tgcggaggag ccagaggagg aggagccaga cgagagcatg ctggactggt

ggtccaagta ctttgcctcc attgacacca tgaaggagca acttcgacaa caagagccct

ctggaattga cttggaggag aaggaggaag tggacaatac cgagggcctg aaggggtcaa

tgaagggcaa ggagaaggca agggctgcca aagaggagaa gaagaagaaa actcagagct

ctggctctgg ccaggggtcc gaggcccccg agaagaagaa acccaagatt gatgagctta

aggtataccc caaagagctg gagtccgagt ttgataactt tgaggactgg ctgcacactt

tcaacttgct tcggggcaag accggggatg atgaggatgg ctccaccgag gaggagcgca

ttgtgggacg cttcaagggc tccctctgcg tgtacaaagt gccactccca gaggacgtgt

cccgggaagc cggctacgac tccacctacg gcatgttcca gggcatcccg agcaatgacc

ccatcaatgt gctggtccga gtctatgtgg tccgggccac ggacctgcac cctgctgaca

tcaacggcaa agctgacccc tacatcgcca tccggctagg caagactgac atccgcgaca

aggagaacta catctccaag cagctcaacc ctgtctttgg gaagtccttt gacatcgagg

cctccttccc catggaatcc atgctgacgg tggctgtgta tgactgggac ctggtgggca

ctgatgacct cattggggaa accaagatcg acctggagaa ccgcttctac agcaagcacc

gcgccacctg cggcatcgcc cagacctact ccacacatgg ctacaatatc tggcgggacc

ccatgaagcc cagccagatc ctgacccgcc tctgcaaaga cggcaaagtg gacggccccc

actttgggcc ccctgggaga gtgaaggtgg ccaaccgcgt cttcactggg ccctctgaga

ttgaggacga gaacggtcag aggaagccca cagacgagca tgtggcgctg ttggccctga

ggcactggga ggacatcccc cgcgcaggct gccgcctggt gccagagcat gtggagacga

ggccgctgct caaccccgac aagccgggca tcgagcaggg ccgcctggag ctgtgggtgg

acatgttccc catggacatg ccagcccctg ggacgcctct ggacatctca cctcggaagc

ccaagaagta cgagctgcgg gtcatcatct ggaacacaga tgaggtggtc ttggaggacg

acgacttctt cacaggggag aagtccagtg acatcttcgt gagggggtgg ctgaagggcc

agcaggagga caagcaggac acagacgtcc actaccactc cctcactggc gagggcaact

tcaactggcg ctacctgttc cccttcgact acctggcggc ggaggagaag atcgtcatct

ccaagaagga cctggcccgc aatgagaacg atgagtttga gctcacgggc aaggtggagg

ctgagctgca tttactgaca gcagaggagg cagagaagaa cccagtgggc ctggcccgca

atgaacctga ccccctagag aaacccaacc ggcccgacac ggccttcgtc tggttcctca

accctctcaa gtccatcaag tacctcatct gcacccggta caagtggctc atcatcaaga

tcgtgctggc gctgttgggg ctgctcatgt tggggctctt cctctacagc ctccctggct

acatggtcaa aaagctcctt ggggcatga

Human Otoferlin Transcript Variant 5 (encodes the protein of SEQ ID NO: 12)

(SEQ ID NO: 18)

atg gccttgctca tccacctcaa gacagtctcg gagctgcggg gcaggggcga ccggatcgcc

aaagtgactt tccgagggca atccttctac tctcgggtcc tggagaactg tgaggatgtg

gctgactttg atgagacatt tcggtggccg gtggccagca gcatcgacag aaatgagatg

ctggagattc aggttttcaa ctacagcaaa gtcttcagca acaagctcat cgggaccttc

cgcatggtgc tgcagaaggt ggtagaggag agccatgtgg aggtgactga cacgctgatt

gatgacaaca atgctatcat caagaccagc ctgtgcgtgg aggtccggta tcaggccact

gacggcacag tgggctcctg ggacgatggg gacttcctgg gagatgagtc tcttcaagag

gaagagaagg acagccaaga gacggatgga ctgctcccag gctcccggcc cagctcccgg

cccccaggag agaagagctt ccggagagcc gggaggagcg tgttctccgc catgaagctc

ggcaaaaacc ggtctcacaa ggaggagccc caaagaccag atgaaccggc ggtgctggag

atggaagacc ttgaccatct ggccattcgg ctaggagatg gactggatcc cgactcggtg

tctctagcct cagtcacagc tctcaccact aatgtctcca acaagcgatc taagccagac

attaagatgg agccaagtgc tgggcggccc atggattacc aggtcagcat cacggtgatc

gaggcccggc agctggtggg cttgaacatg gaccctgtgg tgtgcttgga ggtgggtgac

gacaagaagt acacatccat gaaggagtcc actaactgcc cctattacaa cgagtacttc

gtcttcgact tccatgtctc tccggatgtc atgtttgaca agatcatcaa gatttcggtg

attcactcca agaacctgct gcgcagtggc accctggtgg gctccttcaa aatggacgtg

ggaaccgtgt actcgcagcc agagcaccag ttccatcaca agtgggccat cctgtctgac

cccgatgaca tctcctcggg gctgaagggc tacgtgaagt gtgacgttgc cgtggtgggc

aaaggggaca acatcaagac gccccacaag gccaatgaga ccgacgaaga tgacattgag

gggaacttgc tgctccccga gggggtgccc cccgaacgcc agtgggcccg gttctatgtg

aaaatttacc gagcagaggg gctgccccgt atgaacacaa gcctcatggc caatgtaaag

aaggctttca tcggtgaaaa caaggacctc gtggacccct acgtgcaagt cttctttgct

ggccagaagg gcaagacttc agtgcagaag agcagctatg agcccctgtg gaatgagcag

gtcgtcttta cagacctctt ccccccactc tgcaaacgca tgaaggtgca gatccgagac

tcggacaagg tcaacgacgt ggccatcggc acccacttca ttgacctgcg caagatttct

aatgacggag acaaaggctt cctgcccaca ctgggcccag cctgggtgaa catgtacggc

tccacacgta actacacgct gctggatgag catcaggacc tgaacgaggg cctgggggag

ggtgtgtcct tccgggcccg gctcctgctg ggcctggctg tggagatcgt agacacctcc

aaccctgagc tcaccagctc cacagaggtg caggtggagc aggccacgcc catctcggag

agctgtgcag gtaaaatgga agaattcttt ctctttggag ccttcctgga ggcctcaatg

atcgaccgga gaaacggaga caagcccatc acctttgagg tcaccatagg caactatggg

aacgaagttg atggcctgtc ccggccccag cggcctcggc cccggaagga gccgggggat

gaggaagaag tagacctgat tcagaacgca agtgatgacg aggccggtga tgccggggac

ctggcctcag tctcctccac tccaccaatg cggccccagg tcaccgacag gaactacttc

catctgccct acctggagcg aaagccctgc atctacatca agagctggtg gccggaccag

cgccgccgcc tctacaatgc caacatcatg gaccacattg ccgacaagct ggaagaaggc

ctgaacgaca tacaggagat gatcaaaacg gagaagtcct accctgagcg tcgcctgcgg

ggcgtcctgg aggagctgag ctgtggctgc tgccgcttcc tctccctcgc tgacaaggac

cagggccact catcccgcac caggcttgac cgggagcgcc tcaagtcctg catgagggag

ctggaaaaca tggggcagca ggccaggatg ctgcgggccc aggtgaagcg gcacacggtg

cgggacaagc tgaggctgtg ccagaacttc ctgcagaagc tgcgcttcct ggcggacgag

ccccagcaca gcattcccga catcttcatc tggatgatga gcaacaacaa gcgtgtcgcc

tatgcccgtg tgccctccaa ggacctgctc ttctccatcg tggaggagga gactggcaag

gactgcgcca aggtcaagac gctcttcctt aagctgccag ggaagcgggg cttcggctcg

gcaggctgga cagtgcaggc caaggtggag ctgtacctgt ggctgggcct cagcaaacag

cgcaaggagt tcctgtgcgg cctgccctgt ggcttccagg aggtcaaggc agcccagggc

ctgggcctgc atgccttccc acccgtcagc ctggtctaca ccaagaagca ggcgttccag

ctccgagcgc acatgtacca ggcccgcagc ctctttgccg ccgacagcag cggactctca

gacccctttg cccgcgtctt cttcatcaat cagagtcagt gcacagaggt gctgaatgag

accctgtgtc ccacctggga ccagatgctg gtgttcgaca acctggagct ctatggtgaa

gctcatgagc tgagggacga tccgcccatc attgtcattg aaatctatga ccaggattcc

atgggcaaag ctgacttcat gggccggacc ttcgccaaac ccctggtgaa gatggcagac

gaggcgtact gcccaccccg cttcccacct cagctcgagt actaccagat ctaccgtggc

aacgccacag ctggagacct gctggcggcc ttcgagctgc tgcagattgg accagcaggg

aaggctgacc tgccccccat caatggcccg gtggacgtgg accgaggtcc catcatgccc

gtgcccatgg gcatccggcc cgtgctcagc aagtaccgag tggaggtgct gttctggggc

ctacgggacc taaagcgggt gaacctggcc caggtggacc ggccacgggt ggacatcgag

tgtgcaggga agggggtgca gtcttccctg atccacaatt ataagaagaa ccccaacttc

aacaccctcg tcaagtggtt tgaagtggac ctcccagaga acgagctgct gcacccgccc

ttgaacatcc gtgtggtgga ctgccgggcc ttcggtcgct acacactggt gggctcccat

gccgtcagct ccctgcgacg cttcatctac cggcccccag accgctcggc ccccagctgg

aacaccacgg tcaggcttct ccggcgctgc cgtgtgctgt gcaatggggg ctcctcctct

cactccacag gggaggttgt ggtgactatg gagccagagg tacccatcaa gaaactggag

accatggtga agctggacgc gacttctgaa gctgttgtca aggtggatgt ggctgaggag

gagaaggaga agaagaagaa gaagaagggc actgcggagg agccagagga ggaggagcca

gacgagagca tgctggactg gtggtccaag tactttgcct ccattgacac catgaaggag

caacttcgac aacaagagcc ctctggaatt gacttggagg agaaggagga agtggacaat

accgagggcc tgaaggggtc aatgaagggc aaggagaagg caagggctgc caaagaggag

aagaagaaga aaactcagag ctctggctct ggccaggggt ccgaggcccc cgagaagaag

aaacccaaga ttgatgagct taaggtatac cccaaagagc tggagtccga gtttgataac

tttgaggact ggctgcacac tttcaacttg cttcggggca agaccgggga tgatgaggat

ggctccaccg aggaggagcg cattgtggga cgcttcaagg gctccctctg cgtgtacaaa

gtgccactcc cagaggacgt gtcccgggaa gccggctacg actccaccta cggcatgttc

cagggcatcc cgagcaatga ccccatcaat gtgctggtcc gagtctatgt ggtccgggcc

acggacctgc accctgctga catcaacggc aaagctgacc cctacatcgc catccggcta

ggcaagactg acatccgcga caaggagaac tacatctcca agcagctcaa ccctgtcttt

gggaagtcct ttgacatcga ggcctccttc cccatggaat ccatgctgac ggtggctgtg

tatgactggg acctggtggg cactgatgac ctcattgggg aaaccaagat cgacctggag

aaccgcttct acagcaagca ccgcgccacc tgcggcatcg cccagaccta ctccacacat

ggctacaata tctggcggga ccccatgaag cccagccaga tcctgacccg cctctgcaaa

gacggcaaag tggacggccc ccactttggg ccccctggga gagtgaaggt ggccaaccgc

gtcttcactg ggccctctga gattgaggac gagaacggtc agaggaagcc cacagacgag

catgtggcgc tgttggccct gaggcactgg gaggacatcc cccgcgcagg ctgccgcctg

gtgccagagc atgtggagac gaggccgctg ctcaaccccg acaagccggg catcgagcag

ggccgcctgg agctgtgggt ggacatgttc cccatggaca tgccagcccc tgggacgcct

ctggacatct cacctcggaa gcccaagaag tacgagctgc gggtcatcat ctggaacaca

gatgaggtgg tcttggagga cgacgacttc ttcacagggg agaagtccag tgacatcttc

gtgagggggt ggctgaaggg ccagcaggag gacaagcagg acacagacgt ccactaccac

tccctcactg gcgagggcaa cttcaactgg cgctacctgt tccccttcga ctacctggcg

gcggaggaga agatcgtcat ctccaagaag gagtccatgt tctcctggga cgagaccgag

tacaagatcc ccgcgcggct caccctgcag atctgggatg cggaccactt ctccgctgac

gacttcctgg gggccatcga gctggacctg aaccggttcc cgcggggcgc aaagacagcc

aagcagtgca ccatggagat ggccaccggg gaggtggacg tgcccctcgt gtccatcttc

aagcaaaagc gcgtcaaagg ctggtggccc ctcctggccc gcaatgagaa cgatgagttt

gagctcacgg gcaaggtgga ggctgagctg catttactga cagcagagga ggcagagaag

aacccagtgg gcctggcccg caatgaacct gaccccctag agaaacccaa ccggcccgac

acggccttcg tctggttcct caaccctctc aagtccatca agtacctcat ctgcacccgg

tacaagtggc tcatcatcaa gatcgtgctg gcgctgttgg ggctgctcat gttggggctc

ttcctctaca gcctccctgg ctacatggtc aaaaagctcc ttggggcatg a

A non-limiting example of a human wildtype otoferlin genomic DNA sequence is SEQ ID NO: 19. The exons in SEQ ID NO: 19 are: nucleotide positions 5001-5206 (exon 1), nucleotide positions 25925-25983 (exon 2), nucleotide positions 35779-35867 (exon 3), nucleotide positions 44590-44689 (exon 4), nucleotide positions 47100-47281 (exon 5), nucleotide positions 59854-59927 (exon 6), nucleotide positions 61273-61399 (exon 7), nucleotide positions 61891-61945 (exon 8), nucleotide positions 68626-68757(exon 9), nucleotide positions 73959-74021 (exon 10), nucleotide positions 74404-74488 (exon 11), nucleotide positions 79066-79225 (exon 12), nucleotide positions 80051-80237 (exon 13), nucleotide positions 81107-81293 (exon 14), nucleotide positions 82690-82913 (exon 15), nucleotide positions 83388-83496 (exon 16), nucleotide positions 84046-84226 (exon 17), nucleotide positions 84315-84435 (exon 18), nucleotide positions 85950-86050 (exon 19), nucleotide positions 86193-86283 (exon 20), nucleotide positions 86411-86527 (exon 21), nucleotide positions 86656-86808 (exon 22), nucleotide positions 87382-87571 (exon 23), nucleotide positions 87661-87785 (exon 24), nucleotide positions 88206-88340 (exon 25), nucleotide positions 89025-89186 (exon 26), nucleotide positions 89589-89708 (exon 27), nucleotide positions 90132-90293 (exon 28), nucleotide positions 90405-90567 (exon 29), nucleotide positions 91050-91180 (exon 30), nucleotide positions 92549-92578 (exon 31), nucleotide positions 92978-93106 (exon 32), nucleotide positions 95225-95291 (exon 33), nucleotide positions 96198-96334 (exon 34), nucleotide positions 96466-96600 (exon 35), nucleotide positions 96848-96985 (exon 36), nucleotide positions 97623-97750 (exon 37), nucleotide positions 97857-98027 (exon 38), nucleotide positions 98670-98830 (exon 39), nucleotide positions 99593-99735 (exon 40), nucleotide positions 100128-100216 (exon 41), nucleotide positions 101518-101616 (exon 42), nucleotide positions 101762-102003 (exon 43), nucleotide positions 102669-102847 (exon 44), nucleotide positions 102952-103052 (exon 45), nucleotide positions 103494-103691 (exon 46), nucleotide positions 105479-106496 (exon 47), and exon 48 (the sequence starting with CCGGCCCGAC (SEQ ID NO: 89); see also the description of this exon in Yasunaga et al., Am. J. Hum. Genet. 67:591-600, 2000).

The introns are located between each contiguous pair of exons in SEQ ID NO: 19, i.e., at nucleotide positions 100-5001 (intron 1), nucleotide 5207-25924 (intron 2), nucleotide positions 25984-35778 (intron 3), nucleotide positions 35868-44589 (intron 4), nucleotide positions 44690-47099 (intron 5), nucleotide positions 47282-59853(intron 6), nucleotide positions 59928-61272 (intron 7), nucleotide positions 61400-61890 (intron 8), nucleotide positions 61946-68625 (intron 9), nucleotide positions 68758-73958 (intron 10), nucleotide positions 74022-74403 (intron 11), nucleotide positions 74489-79065 (intron 12), nucleotide positions 79226-80050 (intron 13), nucleotide positions 80238-81106 (intron 14), nucleotide positions 81294-82689 (intron 15), nucleotide positions 82914-83387 (intron 16), nucleotide positions 83497-84045 (intron 17), nucleotide positions 84227-84314 (intron 18), nucleotide positions 84436-85949 (intron 19), nucleotide positions 86051-86192 (intron 20), nucleotide positions 86284-86410 (intron 21), nucleotide positions 86528-86655 (intron 22), nucleotide positions 86809-87381 (intron 23), nucleotide positions 87572-87660 (intron 24), nucleotide positions 87786-88205 (intron 25), nucleotide positions 88341-89024 (intron 26), nucleotide positions 89187-89588 (intron 27), nucleotide positions 89709-90131 (intron 28), nucleotide positions 90294-90404 (intron 29), nucleotide positions 90568-91049 (intron 30), nucleotide positions 91181-92548 (intron 31), nucleotide positions 92579-92977 (intron 32), nucleotide positions 93107-95224 (intron 33), nucleotide positions 95292-96197 (intron 34), nucleotide positions 96335-96465 (intron 35), nucleotide positions 96601-96847 (intron 36), nucleotide positions 96986-97622 (intron 37), nucleotide positions 97751-97856 (intron 38), nucleotide positions 98028-98669 (intron 39), nucleotide positions 98831-99592 (intron 40), nucleotide positions 99736-100127 (intron 41), nucleotide positions 100217-101517 (intron 42), nucleotide positions 101617-101761 (intron 43), nucleotide positions 102004-102668 (intron 44), nucleotide positions 102848-102951 (intron 45), nucleotide positions 103053-103494 (intron 46), nucleotide positions 103692-105478 (intron 47), and nucleotide positions 106497-108496 (intron 48).

Human Otoferlin Gene Sequence (NCBI Accession No. NG_009937.1)

(SEQ ID NO: 19)

1
gggagagcat gcgggctttt tcacccattt ggagactctg cctgcagaat cctcaagaca

61
ttcatttcat tcattcgttc actctttttt tcagacaagg gttcttagga tcattcattc

121
attctataca gatttgctga tactgtacag gttgcctctc agaatccagt gcctgttctc

181
agtacctatg ctgactggta ggagggataa agacagcctt acaccctggg agaggcggtc

241
cagagtagaa acatcagaca ctgtaggaga aagagccaaa gaacaggagg caacagccag

301
acttgcatgt tagatggttg gagtctgaaa atatccagag taaagaaagg taggtgtaac

361
ctagtatttg aaagtgctaa acagcaagcc agcgctcagg gcaagtggcc aggaagcttt

421
ccaagaaaaa cttctgggag gataaaggga ggtctgtgaa aggaccgacc gcaaagtcgg

481
gcgggtactg cacacatgac ccattaacta cggctcttcc ggccttgcca ggttcttcga

541
gcgggcaccc acccggtatc cttccctcct tcaaccaaca agtactgacc ttgcccgaat

601
gctgggtgct ggccctgtgc gccggacgga agggcctgat tttctcgcat tttctctaag

661
cgctggaggc tgcccgcctg gggcgtctcc aagcactaaa ccccacgtgg ctccatctcc

721
tcccccttcc ccggctacat ccatgcgagg tcccttatgc cctgctggct gtgccccact

781
tgccagggag cgccttcctg tgaaggggaa tctggggagg cccccgcccg tgcctgccca

841
cttcctactc tgaaaccaca aacctctagg aaggcccctc gccccgtcgg gtggaaaatt

901
ggctcctcgg ggttccttca accccaaagt ccgggggcag ggggctgaat ttcgatcacc

961
gaggagggcg ctagtggaag ggggagggga ggaggcgctc cctcggcctt acccgggcat

1021
gagtccaggg ggcacgtagg cggcattgaa ctcggtcagt agggtgcccg cgctgcggga

1081
ggccatggtg ggtgcgcgag tacagcgagc ctggcgctcc gctccgcccc acggtaaaca

1141
gcggcgggtc acctggcaac ggccacggcg gcgagcctgg caacgccagc tggccccgcg

1201
gtcctcgcgt tccgagacac tgcgcccccc tggcggccac ctcccggagc agccccatag

1261
ggcgcgccca gaaggcgcct cccatttccg cgagctctgc tgggtgaccc ctgtcacttg

1321
ccccggcgcg tcggggctct ctgccttgct gcctgcggga tgtgcagagg ctcagatgcg

1381
ggagggaggc agaacatcgc tggagaggcc tggcgggatc cgtcttgcgg tgacccggct

1441
tggaacgcga cgctaccaca aaggacaggc caggtcctga ctttggaggt cacgcacgaa

1501
gcagctgccc caccgtggct caggcccaga aacctgagtg gccttagggt ccccaggagc

1561
tatgtctctc caaggcttcc cctgcacccc agctccatgg gagttccagg aaggggctct

1621
gtagtgggcc gcgctgggcg aggttgccta ggacgctgtg tgtaattgtg tgtgtgcgtg

1681
cgtgcgtgca tgtgtgcgtg tgtgtgtgcg cgccttgcga agaggagcat ttttcatttt

1741
tcttcttaat ctctagctga tggcttcctt ctcacctcat catacctgta aactactcca

1801
caagaggcaa aaagaaaatc atagaacgtc tgggtgtgtg atttacattt gtccccaatg

1861
ctgccgttca ttttggggat ggcatccgca ggggtagcgc ttgccccaga gagcaggcct

1921
gctgaaggcc caccccctgt gtaatcctcc ctgtgactgc ttcagcctcc acatttgagt

1981
ttctccaggg acccttacac cagccttggt gcctagggca ggcacagggc cttcggcttt

2041
tccataaggg gtgagggtat ggggacagct tccacggtgc caggctcttg gtgactcggg

2101
tggaggccct gccaccccag ctccctctgc agcagtcctg gtgtcatgaa gaagcctggc

2161
agttcccact ttgtctccag gtcttgcttc ttcccttcag atgccggatg gagagcagtg

2221
ctcccctcgc acttcggttc tgtaaatggc agtggatgaa gaccgcagac gctactgggt

2281
tcacagaatg tggctgccac cagcattctc caaagacttc ccctggcaaa tgccaatgaa

2341
atgaagggga gccacaggct tcccagaggc tcaggaagca gaaacactga ggcctggttg

2401
gaaagagagc tgtaggcaaa ggaacggctg caaacaaact gggtggaagg aaaatccatc

2461
catccttcag aatgcagtca tgtctgtatt tttctaaatt ctcattgggg aacatgttct

2521
acaataagga aaacatgagt caaagacccc cagccctggt gaggttgacc gcctacttcc

2581
tcccccattc agggctgccc agccagtcct gctggtaaac ccaccaccct gccttccacc

2641
tgcctgtgtt ctagtccatc tgtctcgtct gattgggatc ctgtgccatc catatcatat

2701
tcatccctga atctcagcac ctggctctgg aaagaattca gtaaatgttc attacataaa

2761
ttatatactc agttaccaaa atgggtaaca gaagaatgga aattaaaaag tgggttctgg

2821
ctgggaacgg tggctcatgc ctgtaatccc agcattttgg aaggccgagg caggcggatc

2881
acttgaggtc agcagtttga gaccagccta gccaacatgg tgaaacccca tctctactaa

2941
aaatacaaac attagctggg catggtagca catgcttata gtctgaccta tttgggaggc

3001
tgaggcagga gaatcgcttg aacccgggag gcagaggttg cagtgagcct agatcactcc

3061
actgccctcc agcctgggtg acagagtgag actctctctc aaaaaaaaaa aaaaaaaaag

3121
agtgggatct gtctcttagg ttttcagaaa ggccagctga ctccattgag agctgctgag

3181
tggaattgct accattttat ggatgtggaa agtgagattc agcatagatc aatgccttgg

3241
ctagggcagg atcatgggct ttttcctaaa gatgcacagg gtctataaga ggcctcatga

3301
aattcactcc tttcagggga ggacctccag agaaccaagg aagaagatat tttctgttgt

3361
tgttgttgta ccttgtagtc accaagcctt aaaaacacag atcacctgat gacctcatgg

3421
atggaaaatg ctagtgaatt taggtgtttt tttttttaag acattaaact tatctagctt

3481
ttgaaaattt agcattcata cttgtattca ataaacagaa tactctaaga catttttaaa

3541
ttcaatatga ttagataaat gtgagaaagg taagcaagaa ttggttagga aaaagtgcaa

3601
aggaaaaaaa cgtaagtaga aaaagaaaaa tagggcacag tagcaaggaa atatctagaa

3661
ggaggaaaga aggctcttgg gacatactgt aggttatttg gaatgcagaa ttcaaaagaa

3721
gtaacctctt gttaccatgc tgtgaaaaat tagtatttct ctttttaacc tttagactct

3781
gtttcaggta gatccctgag ctcactcttt tatcctttca acagtaattg ggcatcctac

3841
ggtgcacagg ataccatgtg gggctctggg gtagagggat gctgtgctcc agggccctcc

3901
tgaggtcagg aggggaaaag gcaagggaag cagccccagg actcagtaag atgagaggag

3961
gcaggagcag cacagaggag gaccccaacc cagctggggt gcgggtacag aggcacctcc

4021
aggagcaggc actcaagctg agtccagggt ggggtggagg gcattccacc aagaatgaat

4081
agcaagaaca aggctgcaga tgaccctgca cagattccag catcagggat tctggccccc

4141
agcgtccctt tccttggtgt atgctgctgg aagacaggag ggggcagttc tcttttggtc

4201
cttagaaatt tccctataga catcccttct cctgccccta gcagcttata acagcagaag

4261
gccattcaat tctgctcctc tggctggaaa gcaaacatca gcctggctta ccttcgctag

4321
cctgcctgac ccccagcctt ggggtggggc taggttagtg ccctggatcc ttaaacatgg

4381
cccctggtag cacataagcc tctgctgcct ccacaaccag ccatctccat catgcatggc

4441
ctggtcctga gcctcccctc aggcagcagc cccagcctct ctgcttcctg agattcagaa

4501
acagggatcc cagggcaggg ctcagggccc agcctcttgg gggcacagtc tccagcaggg

4561
aagaggtggg cgtaggtgga caaatacatt cccttcttct tgtagtgtgc ccctgtgggt

4621
gggagtgccc cccgccccac atccacccta cctatgctca tgcccactcc tctgtgccca

4681
ctactggtgg cagggcttgc ttagcaggga agcagcagag ccctgcagag gggtgggcag

4741
agcctccctt ccaggagctg ggagaagaca cctgaagctg gacagagctt tatctgggag

4801
ccggcggctg ctgaataatg aattccaact ctgccgcact cccaggctgc acattgggtg

4861
cacacacaca cacacacaca cgcacacacc gatacacaca cgctgggctg acaacttgga

4921
ggggcggggg ctgtgaggct ctgtgagtcg ctgcaggagc agcttagctc ggcttggttg

4981
ccttggtctc tgtgggcagc atcggagggg ggtcgggagg aggaggagga ggcagcggca

5041
gagaagagag aggcgtgtga gccgtgctcc accggctagc tccttcccgc tgctcctgcc

5101
tggcagtgcc aggcagccca caccagcatg gccttgctca tccacctcaa gacagtctcg

5161
gagctgcggg gcaggggcga ccggatcgcc aaagtgactt tccgaggtag ggaagccgct

5221
gtctcagagg gacgccagct ctgagagctg gaccagccca tgctctggag gtggccgggg

5281
ataggacagg gctgggagga tgggtgggaa aagttctagc aggggctggg gcgacgagcc

5341
ttttcacagg tagtcatctg cctgggactg actggccatt gtgatttctg gaaaatcagg

5401
gtcccctgtt cttccatgcc tgtgtctcct tgtgcttgcc aacatgccag ttccccgggc

5461
agggcacaga gccctctgcc tggggaggca gaagtgagga ccacatccct gagctcaggg

5521
agacccagga ccccctcctt ctctctctct ccctctcctg caggttgatt tccttgagca

5581
cagggtgggg gccgggtatg gagcctgggg cacccagggt gactgggaga aaccaggcag

5641
ccagtagctc cctgggcccc agagtgatgg gggacactgt tggcttcttt tagatctatt

5701
catgggcggg aaccccggga gcccctcgcc tctcttctgt ctggtctttt ctcatccttt

5761
tcactcctgt attcagcgac catttattat gatctactgt gtcccaagga taggggtaga

5821
aacacagagc tgagcacaac ccagccccag ccccaaggag cctgcatctg ttgggcaggc

5881
gtggaacaag caggacaggt atgtgagaca gaaggtgggg gtgcagcatg caagctacag

5941
aagcagcacc ctcacccagg ctggtgaccg gtggtcaggg aaggcttccc ggaggaagta

6001
acactcagct aatacccgaa ggaccagcgg gtgggagcta ggagaggagg taaggactga

6061
ggaggcagag gaaacagtgt gcccagagct gagagaggag ctgaaactct ggaactgaaa

6121
gaggttccat gtgtctacag ctcagagagg gtgcaggagc ggaggccaga gagccaagca

6181
gggcaaggag gcgaggctgg acctgacccc ggggacagcg gagcccctga gcattttaag

6241
tggggaaagg cagggccagg ctgactctgt ccttcaccac ccacctctgc ctctccatgt

6301
ggttgctgcc cagccctgag ggttgggggt acttctcact agacatggcc ccttctcccg

6361
agagaggggt ctgagagtgg gatggggacg aggtggtgag aagggggcag agaggacccc

6421
cctatactaa agagcaaagt gagccttggg gcccaggctg gacacagtgt ctgcacctct

6481
gttggaaggg atgggagaga ccattggcag aacattccag caagagccct ggggcaccca

6541
catcacctac ccagaggccc tgggatgccc acattgcagc ttgtgttcat agggacaggc

6601
aggggtggag gtgatggcag tggccctgcc ggcaggcgga ggttaggcag gagggagagg

6661
gaggtgtggg ctgggctgcc ttttgcctcc caccccaacc cactgactgc tttctctgca

6721
gcaccctgga tctccctctg tgtgccacct gcaggctcat gctggcttta gaaaaagcaa

6781
atgtgtcctt tcatctgtga aatgtggccc tgagctccac gggcagcata gtgtggggcg

6841
gttaagctac aggttgccat cctgctgcag ctgtgctgga acggtccagg ctgcaccgga

6901
caggcccact tgcaggccga gaaaccaagg ttcaggggta gaacactgcg cgtggcattc

6961
acggaggagc tgaggcacgg tggtcccagc tctcaggacc tcatcctgag tactcaatct

7021
tgcaagctct ttatctgctc ctgggccacc tgggggccag caccttgtct gacacccatc

7081
ttctccttgg agcagtgaag ggctgggcct ttagcctcac tgaccacaca ggaattagtt

7141
tatttgcaac ccttgctctc tggactgagt ggagaaatcg cttccaagct ccacattggc

7201
aggaggtggc catgggcaga gctcctgggg aagggggctg ggcagcagga ataggcagat

7261
gacaagcagt ttccagaaag tacctttatt acaacgaaag atgcctcagc cgctcacctg

7321
tgtcatctag cagttcacag ttgtaggcgc cccaaaagac caacactgac cacaattcag

7381
agggaatgga cccgctctac aatgttcctt agcatctccc agcacatgca accactgggg

7441
gccaagcaag tcctctgcag ggggaaacaa gaaactggta aacacgcaga gggagacact

7501
ggccccaggc tccccaaggc ttttgagtga aagtcaatgc cgggggaggt ggtgagggag

7561
cccttggtga gctgtgccca ttggcagtgg ccctaggtag gccagagcag ctggttgaaa

7621
tatggcttga ccttctgtgc tgtgccatcc aagacactaa ggaaagagcc ctcctgggct

7681
attgtggaaa aagttctgga tatggagtca gaagccctag atcctacctg ggttctgcca

7741
ctcaccctca gtttcctcat ctgtaaaatg ggcatgataa taacactcac ttcactagat

7801
tgcttcaggg aaaccatagg tatggaagag tttgtgggaa gagtattcaa atggtcgatg

7861
tgtttgtgag gcagccattc ccattctcct tgggagcagc tgctggcccc tgaggtatct

7921
tctctccaga ccagcagagg gccccatgtg agatataaag ggaagaggag agcacgtcta

7981
aggggttcca gtctgccagg agaaggcaga gagcctggac tctgctctgt aggagcctct

8041
gctgagatgt tccgcaggaa cccaggcagg cagacccccg agactcctgt tctcatctgg

8101
ctgggtgtgc accagctttg cccgtggcca cctcttttcc cactgccctc aggccagtcg

8161
gcccctcggt cagtgctccc agccagttct gtatctagct cttagttctt actgcccctg

8221
gctgctccta agctggtgct gccctgttca tgcatttcct gaacatgcta atatttgtgc

8281
acaggcctgg gaccctgagg tgaaggggcc agcctggccc tccaggagtc acaatcccat

8341
tgggtcagac aggagatagg gagtcctggg cgaatctcta ttgtgcctgc aggccacagg

8401
gctcagctgg gtttctcatt aacaaaatgg agacagtggt cctcatttag ctcagaggcc

8461
tgcagttccc aggagtaatc aagagtgggc tatctaagaa ggagccatct tgaccacagg

8521
ttgctactca aagagaggaa gtattagctt caggtatttc ctttatcaac tcctgagata

8581
gttccctaca tcaatcacag agccacagaa cgcagggtgt gaagggtccc gaagttcttc

8641
tagtccaacc ttctgtccag tgctgagcac caaggctggg ggacctggac tgtaagggaa

8701
ccaagtgaca gacagtccag ggccaaccct gatgtctccc ttctctttct atcccctgag

8761
ccttcttgcc aagacatgag gtttggggat tttctgtgtg agataagaac atctaaaggc

8821
tggatctggc ttccacataa ttcactgtgg ctggaaattg gcacaaaggt ttgcagggca

8881
tccccctcca ccttttcatt cttactcttc ttcccaccct ccccctgatt cccaccctgc

8941
tatgttccca ctacattcaa cttccagcca ttcccaaaag ataccacacc cttttacacc

9001
tccaaacttt gagacatcga tcatatttct tctgcctgga atgaccaccc tccaccttga

9061
gaacgcccat taattctgct catccttcaa ggcccagctc atatgctacc tcctccatga

9121
aggagtagta ctttgcacac aaagtactcc tctagcagta ctttgcacac attcttccta

9181
ctgctctgcc aaggtacatt gcatttcaga aactggccac acctctgcat gctgcccaag

9241
cttttgagca tcttcaggac agacatcaga catggtttct gtctttgagg gattcactgt

9301
gtcatgggtt tgagttcttc cactgtggca ctgtcactct ttggctccat ttccccaact

9361
gtgagctctc accccagaac tttctatcca aggaggatca agggactgga agaggcctca

9421
agggccaaga accaagaacc ttggctctta ctccttccat caacttccct aacccagaga

9481
atcttctagg gctccagagg ggcctaacga tttttttttt tttttttttt tttgagtctc

9541
gctctgtcgc caggctggag tgcagtgcag tgcgatctcg gctcactgca acctccagct

9601
cctgggttca agcgattctt ctgcctcagc ctctggagta gctgggacta caggcacacg

9661
ccaccatgcc cgactaattt ttgtattttt agtagagacg gtgtttcacc atatttccca

9721
ggctggtctc aaactcctga cctcatgatc cgcctgcctc ggcctcccaa agtgctggga

9781
ttacaggtgt gagccactgc gcccagtcaa gcctaacaaa tattagcaag ttcagctcca

9841
gcccataggt gggaagcaag agggattgcg tgtgtaagcc agagtcagtt aggggaagac

9901
agaggaagga gaaagggcag acgggaaagg aggtgggagc aggctctgag ttggcccccg

9961
gagctcagaa gggaggcggg agtttttatt gagcagggga aatgggcggt atttaagaag

10021
ccaccgaagg gtcttagttc attggcagga tcaaaggcca tgaaagggcc aggcgtggtg

10081
gctcatgcct ctttccgagc cttactgcga ccacacgtgg ggcaggatct caccatctga

10141
cagaggagaa gaaacataca cacagaggtg aaatgagtgc agcatacagg agggccagcg

10201
gtgggggtaa atagcaacaa tgttcagagg atgacagctt acttagagct acagagacga

10261
gggaaaagga gcaggaggag gaagtgccta agctgggtct tgaaaaactg cccctgtttg

10321
tacctatgga gatgcaggaa gtgaggaatt ggtgatggag gaaggtgaag tctttttggg

10381
tgagggaccg accagaccag aggccagagg aggagaattg cagccaagtt ccatgtcggg

10441
gaagccacac catgtagctg gagcagaggc tataggaagt agaagaggga gaccagctag

10501
ggagggagca gtgggcctgc tgagtgattg tgcagggaag ggttgcagct gaggcactgg

10561
ggacaagatg tccccctact gttggctgca ggctccacct ctgactccac attacattta

10621
ttttccccag taaaatgagg gagccctccc tcttgatgat aaatatagct actatttgga

10681
aacttatctg ccgcccctgg taaaggaggc agaataccca gtgcacccac ccctgaaatg

10741
ctcctgcaat gcctaggcct gtctgtgggc tgtggtccag cctagcaccc cctctcttgg

10801
agaatgtgag gttggcattg tccctgctga aggcagcaat agaggggacc cttacgacga

10861
ccttggcagc cggtggctgg ctgtggacac agccctgcgc ttttgtttta gtcctaacgg

10921
atatgccccc tgcatcctcc attcttcaca gcacactcag tccccctcac cacacctgag

10981
ggaaatcttc tctgcctaat gccccacgta gtgaatgttc tcccctcctc cctcccccag

11041
agcaagccat tgcacaccag cgaagggcag acagagcaca cagaaaattc cccagacttc

11101
tgctttgata ggaagtgtat tttcatgtaa tggaaatgat tgtaaaactg ccttcccctg

11161
caaaagccct caggaatatg ctgctggaaa tgtgcttgag aacagacttg caaatcattt

11221
ctctgaattg ggaagtcttg gttatcttag ccacttttac cgatcatgtg aaagccacat

11281
ctctcgcacc cactcccatc cctgggtctc atttttttct tttttctgtc gcccacgctg

11341
gagtgcagtg gcacaatcat agttcactgc aacctcaacc tcctgggttc aagcgatgct

11401
cccacctcag cctcccgagt agctaggact acaggcacgc accaccatgc tcagctaatt

11461
tttgtatttt tagtagagat ggggtttcac catattgccc aggctggtct tgaactcccg

11521
ggctcatgtg agctgcctgg ctcagcctcc caaagtgctg ggattatagg cgtaagccac

11581
tgtgcctggc cttttttttt tttttttaac tttttatata taaaaaaact ctcaaataca

11641
tacaagagtg gggagaacag tatcatggcc ctatgttgta ccatccaatt tcagctacca

11701
tcaattcatg gccaatcttg cttcatttgc atcccatcct acttcctcac cccaaattat

11761
tttgaagaag atcccaaacc ccataccatt ccatctgtaa atattcagta cacagttata

11821
aaagataaga gctcaaataa ataccacata ctttgtcatt ttaaagaaat taataacaat

11881
tccttagtac tataaactaa tcaggcagtc atcaaattcc taattgtctc atcaatgtca

11941
taattttttt ccaatttatt aaaagcttca ttttaatgtg ttttgtaaat caggtattta

12001
atcatttatc cactcgttct gttgaagggc agccatgtgc cacgcactgg gggatggtgg

12061
ggaatgagac agatgtggtt cctgtcctca aagggggaag atgaccactg cacccatcat

12121
catgaggagc tttatggaag ggaggcacag gtgcccaggc agctcatggt gaggaaaccc

12181
acttagccca ggatgggggg aagccacccc agtgcgtgag ccagagtcag ttaggggaag

12241
actgaggaag gaggaagggc agatgggaag ggagggagga gcaggctcct agttggcccc

12301
tagagcccgg aagtgagtca ggagttttta ttgagcagga ggaatgggcg gtatttaaga

12361
agcccttgaa gggtcgcagc tcattggcag gaacaaaggc catgaaaggg ctgggcatgg

12421
tggctcacgc ctgtaatccc agcactttgg gaggccaagg cgggggggat catttgaggg

12481
caggagtttg agaccagcct ggccaacatg gtgaaaccac atctctacta aaaacacaaa

12541
aattagccgg gcgtggtggt gcacgcctat aatcccagct actcgggagg ctgaggcagg

12601
agaatcgctt gaacccagga ggcagaggct gcagtgagcc gagattgtgc cactgcactc

12661
cagcctgggc gacagagcga gactctgtct caaggggggg aaaaaagcca tgaaaggctc

12721
catcccaggc agaggggcta acactagtgc agacgtggtg gtgtggagat gcatcagggg

12781
agtgtggagg ggagaccgga aggcagggca cgggggacgc agccaaacac ggagggtctt

12841
tggtgtcaca ctcttagcag gagaatggga tgctaagatc ttgttttgga gagaaggctc

12901
tagaggtgag gactgcgggc agggacactg gggaggaagc ccggggcagg cggagggctg

12961
agtgcctcag caggcgccat gagagaggaa ggagcggcgc tgggatcagg ggagtgagtg

13021
acagggcagg gcaagagtca attgtggtcc tggggaccac cgcggaccca gggatttggg

13081
gtacagggcc ttagttgatt ctcatctaga caggtgccag ttgctgacac cctgaattct

13141
ggcaaacatg gagacatcag ggtggaaaca cctggagcca ctgccatcca ggtgggcgcc

13201
ttgagggcca ggccccttgg ctgctttccc agcagcagca tggagcctgg cacagaacag

13261
acctggcata gaagtgggag caaggaacac cgcctgtggg tgcaggagca gtgatcagtt

13321
agcaacaggg gcccccctgc agccagccat ccaggcagca ccagacagtg atccatttct

13381
ctcggtgaca gttctagaaa aggctccgga gacagggact atcatgtgat catttttacc

13441
ctagaccgct tgaccgcttt ctgtctgaac tgatccacct gctagacgct gcctcaacag

13501
tcctcgtttc tattttattt tcttttactt caaagcagaa gggctaatct gctgaggtgg

13561
agacgagttt tcacccactg gctttttttt ttttcagccg aagtttaagg taaagtcagg

13621
actgcagttt ccacaatatt tttaccctat cggagagtaa aagagtcacc ctcccattat

13681
acctcattgt attcccagtg cctggcacag aatgggtact ctacacactt gtggatcact

13741
gggaccacaa gctcctctgt caccgtaaca ggggaatcta ggacccagca gttgatgact

13801
gtgtgggtgg cactgtccaa ggctcaaaga caaataccac aggcccttcc tgcctcagtg

13861
ccagggtctg aaaaatggga accagcgctt tcagtcggtt gcagggcaaa gtcagagttt

13921
gagtgaggac ctggaagaag ggtttgagct gagccagaga gatgggattt atcatccctg

13981
ccctgcccct gcctctcaga tgaatccctg acccaagcct aagtttccat agtgtaaacc

14041
tggatgttag cagggtgggt taaggggaaa tacatgagtg gaggtagaaa tgatatttta

14101
gtacaatttg tggataataa agggttagag ttccatgggg cctccattta gctgagaaat

14161
ggggaaaatg gaaggggtaa ccttttccag tgggaggccc agggactctg cagtatccca

14221
agtctggctc tgtgagtcat tggtgatttt cagagagtat actatgtaag aaacatgagg

14281
aacagctgct ttcttggaca actctttgaa gtgaatttct ttcttctacc atgccatcaa

14341
ctgtcattat aaaattgaag atgtgtttct catggggaaa aaaattgtta ttacaagaga

14401
tatgggcaat tagacaagtc tcaatacatt tcaaaagact gaaatcttac agagtatgtt

14461
ctctgaccat agtggaattc agctaaaaat caataataag aagattatct ttgaaagttc

14521
caaatatttg gaaattaatg cctttcttaa cctatggtca aagaaggaag taaaagagaa

14581
attatgaaac atttttaact gaattataat gaaaatacaa catattaaca tttatcattt

14641
taagtactta cagcagaaaa gaagaaaagt gtaaaattgt aatctaggtt tctgccttaa

14701
aaagatacca aaagaaaagc aaattaaacc caaatcttga aaacattatg ttaaataaaa

14761
gaagccagac acaaaagacc acatactgta taacctcatt tacagtcagg catcgcttag

14821
tgataggagt acattctgaa aaatgcatca ttaagcgatt gtgtcattgt gtgaacatca

14881
tagagtgtac ttacacaaag ctagatggta tagccaacta cacacctagg ctacatggta

14941
tgacctactg ctcctaggcc acaaacgtgt acagaacgta actgtattca atgctgtagg

15001
caatcatagt acaatggtaa gtatttgtgt atctaaacat agaaaagata cagtaaatac

15061
aatattataa tcttatggga ccactgttgt atatccaagt ggtcgttgac caaaacggtg

15121
ttatgtggtg catgaatgta tacgaaatgc tcagaacagg caaatccata cagagaggag

15181
atttgtggtt gtcaagggct gtggggaggg agaatgggga gtgactgctc acgggtatgg

15241
agtctccttc cagggtgatg aaaatattct ggaattaggt agtggtgatg ggtgtacaac

15301
cttgggaata tactaaaaac gactgaactg tgcactttag aaggatgaat gttatggaat

15361
gtgaattata tttcaataaa taaaaatcaa acacccccca ccaaattaaa cccaaggaca

15421
gtataaaagg aaggaaatag aaaatagaca acagagaaat ttaacaaagc caaaagttgg

15481
ttcttcaaaa aaaattaata aaatagataa accctagcaa gacttatcaa aaataaaaag

15541
caagaaaaca caaattacca atatcaggaa taaaagaggg aatatcatta catttaaagg

15601
aaaatatggg aatattacca ataacttacc tcaataaatt ctacaactca gatgaaatga

15661
ataaatcttt tgaaaaacaa cttaccaaaa ctgacagaaa aagaaatgga aaatccaaag

15721
agcctccata tctattaaag aaattgaatt tgtaataaca atgatgatga tgacaataaa

15781
cttccttcca caaagaaaac ttcagatcta gatgatttca ctgctgtatt gtagaaaaca

15841
ttcttttttt ctttttttga gatggagtct cgcactgtca cccaggctgg agtgcagtgg

15901
cgcgatctca gctcactgca acctctgtct ccccagttca agtgattctc ctgcctcagc

15961
ctcccgagta gagcagctga gactacacgc aggtgccacc acgcccggct aatttttgta

16021
tttttagtag agacagggtt tcaccatgtt ggccaggctg gtcttgaact cctgacctca

16081
agtgatctgc ccatatcggc ctctcaaagt gctgggatta caggtgtaag ccaccacacc

16141
cggcctgtag aaaacattga aaggaaaacg taataacaat cttacacaaa ctctttcaga

16201
aaatagagaa ggaagagcac atctcaattc attttttatt atcaaaacct gacaaagacc

16261
ttacacaaaa agaaaattac agcccaatat ctctcatgaa cacagatgta aaaatcctta

16321
acaaaatatt agccaactga atagcaatat atgaaaagaa taacacatca tgacaagtga

16381
gtattatccc aggaatgcaa tgttaattta aaagtagaaa atcaaaatat tttaccatat

16441
taacacagta aaggaaaaaa ttcatgatta tatcaataga tgcagaaaat gcatttgaca

16501
aaattcaaca cccattcatg ataataacta tcagcaaact accaataaaa ggagcttcct

16561
caatctgata aaaatcatcc agctaacatt atacttaatt cagaaatatt gaacattaag

16621
atcatgagtc aggcaaagtt ttctactctc accacttctg ttcaacactg tgctagaatt

16681
ctagccagta caaggtggca aggtaaaaac aactcctaca gattggaaag gaagaagtaa

16741
aactatcttt attcacagaa aacctgattg gttatgtaga aaatcctaag gaatctatta

16801
aaaagctact acaattaatg aatgaattta gcaagttttc aggatatatg attaatacac

16861
aagaaaataa attttaccaa agacaggaaa gacttccacc ctaaaaacaa aacaacacaa

16921
aatgctgaga gaaataaaaa aaaaaaaaaa ccaaacatgt agaaaataga ttatgtttat

16981
ggactgaaga ttcataattg ttaagatgac aattctccac aaaatgatct atagactgaa

17041
tgcaatccta ataaaaatca caacaaacta ttttgtagaa attgaaaact actttaaaat

17101
ttatgtggac atgcaaatga tctagaatag ctaaagcagc cttgaaaatg gagaagagaa

17161
ttggagggtt cacaccacag ctgacccctg aacaacatgg gtccacttat atgtggattt

17221
tttttttttt tctttttgag acagagtttc actcttgttg cccaggctgg agtgcaatgg

17281
agcaatctca gctcactgca acctccacct cccgggttca agcgattctc ctttctcagc

17341
ctcccgagta gctgggatta caggcatgca ccatcactcc cagctaattt ttgtattttc

17401
agtagagacg aggtttcacc atgttggtca ggctggtctc gaactcctga cctcaagtga

17461
tccaccagcc tcggcctcct aaagtgctgg gattacaggc atgagccact tcgcctggcc

17521
atggtttctc ttccttatct tttttcctaa cattttcttt tctctagctt actttattgt

17581
aaaagtacag tacataatac atatacaaaa tatgtgttaa ttggctgttt atgttatcat

17641
taaggcttct ggttaacagt agtctattag tagctaagtt tttggggagt caaaatttat

17701
atgcagcttt tcaactatat gaggggctgg tacctctaat ccctgtgttg ttcaagggtc

17761
aactatattt aattataagt ctaactataa agttaaagga attaagaaag tgtggcattg

17821
gtctaagaat agacatatag accaatggag cagaatagtg tccagaaata aactctgtac

17881
atataaaatc aattgatttt caatcaaggt gttggatatc tagaactagg tatctatatg

17941
gagaaaaaat gaacttcaaa ctcctacctc ataccatcca caaaaattaa tgtaagatgg

18001
attatagaat taaacattaa aaacttataa gcttctagaa gaaaatatag aacatctttt

18061
tttgtattct tgggttaggc aaaggtttct taaagaaaaa ttttaaaaga ctaaacataa

18121
gaaataaatt tcactaaaaa cttgcatttc ttaaaaattg gaaactctct ttggctagtc

18181
acagagtaaa aaaaattgaa aactcctatt cataaaaaaa tcacatttaa gaaggcaaga

18241
gaaggcaagt cacacacagg aagaaaatat tcacatttat ctgacaaagg acttgtagcc

18301
agaatatata aagaatccct ataagtcaat aataataaga caaattatga aattttttat

18361
gtaggcaaaa gacttgaaga gacactccat agaataagat agacgtatgg ccaataaaca

18421
tgtgaaaatg tgatcaacat cctgagtcat tagagaaatg aagatcaaaa ttacaaagag

18481
atattatttc acatgctcta aaatagctaa aatgtaaaag tctgacagta atcaaatgtt

18541
gatgaggatg gaacaactga aatttttttt acattgctga taagagtgtg aaatgatgca

18601
atccccttag aaaactattt ggcgatttct ttcttttctt ttcttttttt ttttttttgg

18661
gatggcatct cgttctgtca cccaggctgg agtgcagtgg tgtgatcttg gttcaatgca

18721
acctttgcct cccgggttca agcgattctc ctgcttcagc ctcccgagta gctgggacta

18781
caggttcgca ccaccacgcc tggctaattt tttttttgta tttttagtag agacagggtt

18841
tcaccgtgtt agccatgatg gtctccatct cctgacctca tgatctgcct gcctcagcct

18901
cccaaagtgc tgggattaca ggcatgagcc attgcgcccg gccagcaatt tcttataaag

18961
ctaagggtac ctatcctgtg acataaccat tctgttctta ggaatttcct caagagaaat

19021
aaaattatat tttcagaaaa agactcacat gaatgtttac agcaactttg ctcatatagc

19081
ccaaccctag aagcacccaa aagtttatca tcaacagaga aatggaccaa gaagttgtgg

19141
tataggcatg caacgggcta ttactctaca ataaaaatca atacattact tatatatgca

19201
acaacatgga tgaatcacaa aaacattacc ttgaccaaaa gaagccagac acacaaaaag

19261
tacattctgt aggatacctt ttatatgaag tttaaaacag gcaaactgat ctttggtgct

19321
agaaatcaga gcactggtta ctaagggact agaaatcgac tggaaaggga catgagagaa

19381
catgtggaac aaatggaaat gttctatgtc ttgattgtgt ggcggtatac agggaaatgc

19441
atttattgaa actcattgaa ttttacactt aagatccatg aatgtaagtt tcacctagtt

19501
ttaaaaaaag aagagagact cacatctaaa atacctaaaa cttgaaaaat attatataag

19561
atgaggaaaa aaattatttc tgattccatg ctactaaaaa taagctacaa atgtgattca

19621
taatagaaga agccattttt atatttagca cataacttaa aggtctaaag gacaagcaag

19681
ctgggcgcag tggcccacgc ctataatcct agcattttgg gaggccaagg caggaggatc

19741
acttaaagtc aggaatttga gaacagcttg gccacatgct ggtgaaaccc tgtctctcta

19801
aaaatacaaa aaaagttagc caggcatggt ggcacacgcc tgtaattcca gctacttagg

19861
aggctaatgc aggagagtca cttgaaccca ggaggtggag gttgcagtga gcggagatta

19921
cgccactgca ctccagcctg ggtgacagat caagactccg tctcaaaaaa ataaattcaa

19981
aacaaaatag aatgaaggag aaacaagact atttagtaga ctgagaatag ctgtttctta

20041
ttgagggata aactgcacca aatgctattg taagcattat tatttccttc attttaaggg

20101
tgaggaaaca agggcaaaga gaagttaatt agcttcatcc agggcacgca aactaggaag

20161
aggcagctgg gatttgaact cagggactct ggcccaagag ccttaacctc tatcccatgc

20221
cccctcgtgc ttgtaaagga cttgatgctt tacttagact ttcccacaac agtttcttgt

20281
catcctcgtg atggtcccag gacacaggct ggtccaggat aatgaccccc ggctaacaga

20341
tggtgagtct gagaccccaa ggggttggat ggccagctcc caggcctcca gaccatgggc

20401
cgttgtgccg ggccgcacac ctgagtgggc ctggcttttt cctgcacgca ggggtgcttg

20461
ggccctgctt cctggtgctc catgggagta tctggccttc aaaaggaaca gatcgatctg

20521
aagtggggag agagaaaata cagcaggacc atcactcaga gagtcgctgt agaggaagag

20581
agggagagga gacgccagga catgggagct ttgtgggagg gaatgggact atttgctgag

20641
ctttgtacag cccagcccag gcagtgcata caacaaggct ttgctgattt taaataacac

20701
aaggaaatag cagccccagg tctgagtcac cagcagagtt ttactctatt tctcagctca

20761
cacagggaca atagcaatgg caggcactgc tgggagatag gctagtgggc tgggccctgg

20821
caaaatcacg acgtccttga aaacagtccc aggaccttct ccttcccctt cggatggccc

20881
accacctcac cctctgccct ttcgggaccc cagcccctct ccagtcttgc ttccacaggc

20941
tgctccctga gggcagacca ttcttgcttt tcccttcacc atcgggactc ccctgtcctg

21001
tgtccagctc cttggaggct ctactctctg ctctacgctt tcaaacattt ccttacactg

21061
ttctctctgc ctggatttcc ctccttctcc ttgcttccca gtctctctga atatccagat

21121
ttcttctggt cttctagcgt caatgcgtgt gcctctgcaa tgcctcctta atccactaca

21181
ttgagagtca ttgctccttt tcctgtgttc tcactttatt tacacttttt gcatgccaat

21241
gacaaaattc tgccttgtat catcggcaga attttccatg tctgatatat ctccctctgg

21301
attgtaatac gctcttaaag gcatcgttca gattcgaatg atcttagtac aactcccctc

21361
tgtgaaggcc aaatggcaca caagccagga gctagaaagc cctggttgcc tgtggaaatg

21421
aatgaacaca catgggctgg cagccgtgtc cctgcacacc tgccttttct cagaggtgtg

21481
gccctagcag ggtaagctgt ctggaagagg gagctatttt gtgcagatgg aacattttgt

21541
ccccttaaat catgtcccat gaaaggccag catggcatcc tgcttctgaa acaagcactg

21601
agctcgtctc catttggaga agatctgtcg tgtgggtatt tttaaatggt gaaaggagaa

21661
atgggtatat ctgataccat ggcacttgtt acactttaag cacagactct gttattcata

21721
ctccatctat tgactcaggg aggagtttat ttcaaaccaa acagctcagc tatcccagga

21781
gcagctgcct cagaaggaag gaggatgctg ttctatttcc cccatcgaac ctccttctca

21841
ctcgatccac aacagccttt ccatgcaagg aagaggctat tttctttcaa gctttattct

21901
ccattttccc tgtggcaaga aaggtgattg gatattggga tttgtaatgg ttttatctga

21961
aagccattta aaatgaagct ggaatgtcaa caagactgac gctgaatgga gtagatgtga

22021
agtggaaatg aacttgaaac aagagatggg gttagtcatc cccctgatca cttggaacag

22081
atgatggagg tcccctgcct ctgctccagt gaacagaaca gaaccacttg aatactgcca

22141
gccactgttt gtacataccc tcctgaaacg gctcttccaa aatgctgaag gacattttgt

22201
tttcttaata atttggcctt tccactgttt ctgtatgatt gatgtgtttc agcaaacctt

22261
ttttaaaaaa gaatatctac aggtaaattt agctcatcat gtttgagaat attcaccatc

22321
tctaaatccc cagggcctaa atcaatgagg ttttagcaca ttttgaaaca gaaccctgat

22381
gtataaattc tgcaatggct gatttcacgt attttacttc ctctctaaca aagctatgga

22441
aaaatgcaca agcaggggag ggtttgatcc tcggtgtttc ctgcagatgt gaatctgaca

22501
ccaccttgga gcagggcccc tccccacctt ctcccaatcc tccgctgggt tgctgcattt

22561
ttcactccaa gagaccccgg aggacagcta tatccgaggc ttattaaaat cttctaggat

22621
gcaaaggcct ttggttattc agagcagcag gtctttaggg gaagccccca tacacaaaca

22681
tgctcagctg attctcaatt tatattgtgt gttacctgcg gggaaaatta aaagctcaaa

22741
cctcaggcac tttccctctc ctcccttgat tgcccggggg cttgttgttg agatatttct

22801
tgttgatttt tttgtttttt atgtctctgg ctggtgctaa acattctttc tttcccatca

22861
tgtttacttc acatctcttt gccgtataga tagcttctgc tttatggttt tttcctcctt

22921
atctcagatg cagccagccc ttccccacct gcccccgccc caaaacacac acacgaacac

22981
acaccctttc agactgcatc cacactctct gtttcagtgg atctgacatc aacgaccccg

23041
ccacccccgg ccctcgtcag aggggagctc tgcattgaac taggactagc tcctgggtca

23101
taaaagttgc taggaccctg gagagctctt actaaacaga tgaggccacc actgacagag

23161
gagagaggtc agttcccgga gggaacgagc ctgctttgct gagccccctt ccttgcccag

23221
cccccagacc catcacaggg aaggttcaga ggagctctga cccctccagt acctccttgg

23281
cctgacgccg ctctagcccg ggctcccagg ttttctgtag ggagaggagc acagtccgct

23341
ccacccatgc catgggcttc atcagtgaca acccaaactc acccccaaat aggaatggct

23401
tcaacctgga gacagccctt caatgaaatg gtttatgctg gtggagattt aaaggtattc

23461
gtctttcggc tgggcgcggt gactcacacc tataatccca gcactttggg aggccgaggt

23521
gggagatcac ttgaggccag gaattcgaga ccagcctgac caacatgcga aaccccatct

23581
ctactaaaag taaaaaaatt agctaggcac agtggcgcat gcctgtaatc ccaactactt

23641
gggaggctga ggcacgagaa tcatttgaac cccggaggca gagtttgcag tgagccaaga

23701
ttacactact gcactccagc ctgggtgaca gagcaagact ctgtctcaag acaaacaaaa

23761
agggtgtttg tctttcaatt gcaaaaatca agcatggtca ctgaaaaaaa attcaaattc

23821
acatttcatt ttgttttgtt ttgttttgtt tgtctttcag ccaggtgcag tggctcacat

23881
caaagtatgc tgctttcaat atcttctcac tctccctccc cagggataac cactttcttt

23941
tttattttat ttatttaact tttttgagat ggagtttcac tagttgccca ggctggagtg

24001
caatggcgca atctcggccc accacaacct ccgcctcctg ggttcaagcg attctcctgc

24061
ctcggcctct tgagtagctg ggattacagg catgtgccac cacacccagc tatttttgta

24121
tttttagtag agacggggtt tctccatgtt ggtcaagcag gtctcgaact cccgacctca

24181
ggtgatccgc ccgcctcggc ctcccaaatt gctgggatta caggcgtgag ccactgcgcc

24241
caggggggta accactttca gtggtttgag atgtttgtct cttcatagaa gaaatatatg

24301
catatagttt gggttttggt atttttttta attaatggag ttctaatata catgctgcct

24361
tttttccctt accatggaat tgacacagga taataaatta attctaagca acaaattttt

24421
ctttaaccca tcctgtctct aggtttctcc tcacagaaat tacaacccct tctcttgtgg

24481
ttccatccca tccctaaaac agtatttatc ctcccttctc tgtaccatta ctgtttcttg

24541
tgcgaaattg taccttggag tatgtactga atggtgttgt actggaggcc tggcgcggtg

24601
actcatgcct gtaatcccag cactttggga gaccaaggtg ggcgggtcat ttgaggtcaa

24661
gagttccaga cgagcctggc caacatggtg aaaccccgtc tctactaaaa atacaaaaat

24721
tagctgggca tggtggcggc gcctgtaatc ccagttactc aggaggctga ggcaggagaa

24781
tcgcttgaac ccaggaggcg gaggttgcag tgagccgaga tcgtgccact gcaatccagc

24841
ctgggaacag agcaagactg catctcaaaa aaaaaaaaaa aatggtgttt cccttgcact

24901
ggtgccctgt tggctcctgg cctcccttct agaccatcag ctacctgtgg gtgggagcct

24961
gtgcctttgt cattggtcca tcctctatcc cgaggccccg ggacatggcc tagaacatca

25021
gagactccag cggctgtttc tcaaagtgaa ctgaactagc tggtgtttcc cacacgatgg

25081
agccccctcg acctgccctc gattctctcc tgacttattt ctccccacat cttgggccag

25141
ttccagctgg actagcaaag agggcagctt tacctctgtg ctcccaacat gccctagtgg

25201
gtggcgtatg gatgggggag cctgggacaa tgtgtgtcca tctcacacac tctctacttc

25261
ccatgccagt ggggaaagtg ggggcaggaa tagagcccgg gagggaactg ccagagactg

25321
tcttctctgc taaggctgac aggaagacgg acaaccatga cagtggtgga aggggaaggc

25381
ccttggccca cggggaatgg ctgtctggaa gctgacttgt tgttgggggc ctggtttggg

25441
caggaacccc tggggtggct gcagaaggag gctgggcttc acagacccct gtcggcaggc

25501
aggggctacg ccccctatac taggcttctg ctcagggcag cagggcccgg agccaccagc

25561
agagctgagg aggctgcaga ggaggctgag agatccatgg aggaagaaca tggtggaaaa

25621
gagtgcctga ggtccgcttc cacggccact ctgaccagcc tgggccttct gtgccttagc

25681
attcccgttc ctaacatgga actcatggcc tttgacccgc ttccctcacg aggctgctga

25741
gagggtcaga gaagaagccg catggggact ggcctcaccc tgggagaggt gagcaagcca

25801
cgaggtccca tgttgcatga aaagtcaaat gctgttagga cgactcccag gatgaggagg

25861
tctgacccca tgctcatcgt ctggacagct ctgaccctag aatttatttc ctctttcccc

25921
acagggcaat ccttctactc tcgggtcctg gagaactgtg aggatgtggc tgactttgat

25981
gaggtaggag gcccaagact cccccctccc tcagccctga gcccagaggg gaacagccac

26041
ccttcgctgc ctcttgcggg cacacactgg ccccaaatcc caggcactgg cctgctctga

26101
gcccctcacc tctcagctgc ttcctgaagg aggtggtaag gagggtgtgc aggaactccc

26161
tcccccatgt tccccccaga aacctctgca caggtgaggc ccgtgtgcaa atgacacggg

26221
gaacagcagc ctcgcccacc tcgacggccc tgctgggtct gggcctgtta ttccctgtgg

26281
agaaagagcc cacaggtgct gtagacctga atgtgagcca ccagctgagg gcccaacgag

26341
gcaggcgagt gttggggacg tcgcaaaggc cagtctgtgt cagtccccag gggttgaaga

26401
gcagggcagc cccgggcact gaggtaggag ccccagtcac cagggaaaca ttgtcaagca

26461
ccccacctga gtgagggcgc catctccaga ccttgagggg aagcataggg aacagaagac

26521
agtctggatt ttcagaaaca gctctggggg ttccatgaga aaagacgtga gctgctggtc

26581
tattgacaac gatttttctc aatcctcact ccagctgggc tgttgtcaca attttatcag

26641
caaaggagca ggcgacacca tcccacaggg gtgcccagga gcagtgagag gacttacaac

26701
gcttccctct ccctgccctt cccctcggta cctggccggg ctgggagccc tatcctcaca

26761
cacacacacc agctcgagca gcctgcggcc tcctccgcct cctcacattc tttcgtctat

26821
gtgtttgctg cttccagaat ctatattccc ctctggctgc tgtaggttct ccagggatga

26881
ctttggagtg agggccagca gtcatccgtc accatcttag cacaaactgg aagccatgta

26941
gtgaccctca aatagtgtac cccctctctc ctggggttgg ctctcccgct tggctctgtg

27001
ggggctggga agggcctcat agcagactgt gcctcttgag gttggctgct ggcgttcggc

27061
tgagcagcca ccaggctgac acttggcacc agctgtctcc ccctcctcca gaaaccaggc

27121
cacacgatgt ggctgtgtcc atcgacccag agctggagac acagggagca aaacctcgct

27181
cctcactcag gcttaggcac agccatcaac catcgcggcc cagcaccaca ccctccccaa

27241
ccacttcagg gcgcagttgc cacgacctcc ctggtacgtc cccactgcta tgcaggacag

27301
gtgaatcact catttaaagt gaatcactag agctaaggaa gtttctgtcc ttaccttctc

27361
cccctcctgg ctgtacaatg acctcagttt ctaaacctgc caccatcttt gtcaaatggg

27421
gttggtgatg ggtgtgaagg tctctgtgaa atgatgaaca aaatgaaggg ttatggtgag

27481
agtggaatca tggctgccca ctgagacagc tgtcatagat gcttcaggct tgccccatta

27541
cacacccggc ctgctccctc ccctccccat ttcctcagtc agggcactgg gctggctggg

27601
agaagatgcc agcagcctgg cccagtttcc catagtccta cctccctggg cttctgccca

27661
ctaatccacc aggcacagca tctgactccc tcctcccaag actcccaggg gatatgtcag

27721
cccaggcgtt cagccagggg gcaacctgat gccccttcca agggcactgc cacccttttc

27781
catgcccagc gccttggaca cctgagccac aggtatgcac gacattcaaa gttaatcacc

27841
atgtcgttcc tcttcccaac tccgcccagc ctgcctcagg gggagagtct gtctctgctg

27901
gccctgaaca aggggccaca ttccgagcat ctagtgcatg ccaggccggg cttgagatat

27961
cccagaggca ggaacctggg ctcaacaccc catgatgatt tgtatgggag cttagggatg

28021
gggtagccag agtcagtgtg gagagactgg ggcagggcag aagcagttat ggaagaagca

28081
catgactagg gtcagagagc agggcacgcg atggggagaa gaggctcctg cccggggaaa

28141
gtgctgcccg cccactgggg agacagggaa gtttctggtt gttgcaatga ggagcctact

28201
ggcatttagt ggggtgggga gcaaggatgc agaatgactt gcaatgctca ggccatcccg

28261
cacttcccac ctgggagccc cgtgggaaga tggtggcagc cccagcagca gcactgagct

28321
gcttcccgag ccatgcccct tccactcaat ctccgaaatc atccacagac gaaattaggc

28381
tcagatggta actacccttc cccaggtgac agagctggaa gcggccaagc cagggttctg

28441
aattcatgca tagattagac ctaagccctc tctggataca gtgatagggc ctgactccca

28501
ccacccctgc aaggcccgtg ttggagtctc tccacacccc ctgcctccat ttctccctgg

28561
gcaaagtggc ctcagccctg gccaccaatg gtcagcagtg cacatcccac aaagcaggaa

28621
ggccaccctc ccattccctg ttcaggaacg gcccggaggc ctgggtcagc ccagtcccaa

28681
aggtagcctg gagccatacc ctggctttaa cctttctccc tagacccagt ggacaagttg

28741
taaacttccc tggcttcccc ctgaaagaat ctgcctgcca gtggttccag aatatcctgg

28801
gaaagagccc tttcaaatcc ccctgaacct tcttgacttt ccagaaagcc tcttctctcc

28861
gtcttactct gcccagggcc tgccggagcc agcttagtga gacacactgg cctgggagtc

28921
atgagaccta caccacagtc cttgctgagg aacctctttg ggctttggat tccccttctg

28981
taaaagagag atatgctccc tgctctatct gccccacggg actgtcacaa ggctaaaaaa

29041
agatgaaatg agagacaaga aagcaaatgt ctctcacagc tctactaggt aaggggttcc

29101
aagcaaggga ggggcccctc ctctgctcag gcatgggtga gaggggctgc agcagctggg

29161
cttaggaacc tgagtgggga ggaggatgcc atggaagaaa gacaatgctc tctacaacaa

29221
tgggtggaaa cagagcctgg acatggtgtc tcctttccca gaggctggaa cctgagcccc

29281
tacatttaac ctacaactct ggaaaagcta gggagagaca gagaaagacc cagcctttgt

29341
gacctgggga aacaggagta gccaccttta gccagtttgg tttggctcta acacaggccc

29401
tgtgtggagc aggccccagg ggagaggcca gagtaacaat agtacttgtg ccaatgataa

29461
gaagaactgc tgctatttac tgagcactta gtgtgtggca agatgggctg agagcttgac

29521
acaagcatta gactcactag aacttgctgg attggtagca tcctaggtga taaggagcca

29581
caacaggatt taaacccgag tctatctgat tccaggacct atggtcattt gtaaagtaga

29641
caagactcag ccctgccctc aaggggctca gtctagcggg cagatggacc cactacaaac

29701
aaggagggac cctgggcctt ctgagccaag aggaagaaga ggtctccagc ctgggggatg

29761
acagggcagg ggagtttggc cttatctgcc cctttctgct tgtaccagga agtcatggct

29821
gttacctcct ggaggccaga aacgcacctg tcttgttcgt cattggcctg gcacccagca

29881
tggagttgag aaaatgttgc cgagtgaaag aatgaaaaaa acagtgacgt tcactaggac

29941
tggcacctgt caccgcaggc ctgtgcccag accgagtggg ctcagcaggg ctagtggtac

30001
atcaagccct ttgctgtggc ctggatagaa aggaagcagg caaggcacag atgagatcac

30061
ctaaagggac tttagatcac cttgatctct aaggttagag atcatctagt ttaaccctct

30121
tgtcttgcag ttgaagaaac aggtcttaga gtggggaaga gaattgccca agaagaccag

30181
ctgagatctg agatcctaca tttaacttac aactctaaag aagctgggga aagagacaga

30241
gacaaagaca gaaacagaga gagagagaca gagacacaga gacccagcct ttgtgccctg

30301
ggaaagtgaa atagccacac tcgggatact gagcccaggc ctttaagctt gcaaatccgt

30361
ctctttccat tgtactctaa agcagcagtc cccaaccttt ttggcaccag gggctggttt

30421
cgtggaagac agtttttcca cagactggga tggtggtggc tgggggttat ttgggatgaa

30481
actgttcctc ctcagaacat caggcattag attctcttaa ggagtgcaca gcctagatct

30541
cttgcatatg ttgttcacag tagggttcac actcctatga gaatctaatg ctgtcactga

30601
tctgacatta gatggagctt aggcgggaat gctcgctcac ccgcggctca cctcttgctg

30661
tgtggctctg ctcctaacag gccatggact ggtactggtc tgtggcccgg gatatgggga

30721
cccctgctct aaagctttgt agtgcatctc aatattttcc cccaaaccta tagccctgtc

30781
cctttaagga tgctaccttg ctgatttagg atggttccag gcccactcag cggccaagct

30841
ggacataatc cagatcattc tccaaggtac atcagggaaa ccttttttgc agagtcctag

30901
atcactgggg ctgataggat gcagaaccct gtgccccggc cagcaccagc caggtcaggg

30961
ctaagcctag accaggaaac tgggtcagga ctcagcactc cccgggctcc tgagatcact

31021
ccctccaaca gaggccctct ttccctccct atctgtacta cctaccacct tgcttctgtc

31081
aacagtccta tcccaggctg ctattccagg tctgtgtctg tctccagaac tatccaggac

31141
catccccagg actgagaaac aaccctgcat ccctgcgttc tgcacagcgt catgcacaga

31201
gcctggcaca cagcaagtgc tcagcaaatg ttcgccccca gcatggggct tgctggctcg

31261
tgacatcttg agtgactgtg tttggcttaa ctgctacttg agtcccccag cagtaccagg

31321
cttcaggaga ggattcagtg tagtggatta agccctgagg actgaactcc agactaagca

31381
tcctgagact tgagtttgaa tcctgcctct gccaccaacc agccttgtgc ccgcgggcaa

31441
ctctcgcctc tccactttcc cacttgtaaa aggagcacat ctttgccatg ttgctgtgag

31501
cttggttatg ggtaaatgtg ctctggaagt actaagtcct acccagatga aattcttcct

31561
tcagaagccc ttttccttca gtcttttttt tttttttttt ttttttgagg tggagtctta

31621
ctctgtcacc caggctggag tgcaatggtg ccatctgggc tcactgcaac ctctgcctcc

31681
caggttcaag cgattctcct gcctcagcct cccaagtagc tgagattaca ggcatgcacc

31741
accacacctg gctaattttt gtattttagt agagaccgtg tttcaccatg ttggccaggc

31801
tggtatcaaa ctcctaacct caaatcatct gcccactttg gcctcccaaa atgctgtgtt

31861
tgcaggtatg agccactgcc cccagccccc tttccttcaa tctaatagct cacaagttca

31921
ataccatagt caggagagga gtgtagctcc caaaccctca aaatcctcat ctcgtcttgc

31981
tgtgttctca gcatatcacc ccaaatggag gaaaggacat aaccacaaaa atgaggagac

32041
aatgaaaaat gaaattaggg aagagaagat gcagtgaaag agacacgtga aatccacagg

32101
ccgaggcaga agaggaaagt gatggcggcg aaggggaggg aggtggcatg acaaggagac

32161
aaggcagttg cagacctgca cagagttccc actgggaaga tctaaactaa acacattctg

32221
ccgtgctgtg tcacttacga ctgctgtcac ctgtgagatc ccatttgatt ctctcaatag

32281
ccctctaagg tagatattgt cacccccctc ttttcacaga tggggaagct gaggcacagc

32341
tagtgagtgg cagagccagg gctagaactc aagtctcctg actcaaactc agagtttctg

32401
caacaccacg gagactccca gtctgcgtga gatacaagcc tcggtgttgt cagaagaaca

32461
aaaaagaagc aaagggtggg catgtccttt ggagctctgt gaggtgccca gagctcacag

32521
aggctgcctc agcaaaggaa ggtgtcagca atgggagatg gggctggaaa tgctgtctgg

32581
gcacagcaag ggggcctctg ggtgctagga aggggaatcc ccacctcttt cagggagctg

32641
tagaggagcc actgaaaagt tttaacaaag gagagataaa aagagaggaa aattcaaccc

32701
caaaagtctc cttcttacag cccatgcctc tacttccagg gaggccaaat gggagtaacc

32761
cccagtccca gaccctgagt cacttccctc cagccaagag gcccgtcacc ctccgaggcc

32821
ccacactgat gccaggaccc cacctagagg tgccggcttg atcggtctcc aggctgggcc

32881
ttgggatttt taaaagcttc tggaatggat tgcagttcca gccaagatga agaacccctg

32941
agaaagacag agggagacag agacaaaggg agagatagag acagagagag aaactgatga

33001
aagaaaacag atgtggtgag gagaagaaag cagacgaatg atgcgggagg gaaggaaaag

33061
aaatgagggg aaagcctcgt gtgggtggaa aatgcgggag ggagacaggg gaggaaagaa

33121
aggaaactgt aaggtgggag caagtcagag accgaagaag ctgctgtgac tcagtgagga

33181
ccctgtcttc tccctcaccc ggaaagcctc caagaagaac attccccgct gacataggca

33241
tggactgccc agacccggct gacgaatttc tgaaagggca cctgagccac acacctacac

33301
acgcttcccc tgattattct catctgcagt caggggcccc ggaagccccc tgtctcctgt

33361
gccctccctg tcccccgact ctcactcaac aaactggccc tcgccccgca gccaggcagc

33421
ctccctcccc aggtccctta gcctcagcct cccgccaccg ttcaacaccc cacctccctt

33481
tcacagggcc atctccaaag tcatgtcctt tttctcctga tctttctctc cttccaatgc

33541
caaaatccca cccacagacc ctcaggggga ccaatcaccc ctcccctctt catccccagt

33601
aaaccaaatc tcggtggctc ctgcggcccc ccgactccca cacagcgccc tggctgatga

33661
gctgggcctt cctgggctgc tttatttccc tgcagcccca taaaagcagc ttcattaaga

33721
aaaccacaca ctctgctgag ctgccagagg catccagaag ctggagccgc agccgctgaa

33781
tgaggcctgt gggccgggct gcctccactt cctgggactc tcagcgcacc cctccgccct

33841
gtgcccacct cgcctctgaa gccctcccta ggccctgctc agaaccctcc ccaccccacc

33901
ccgcagaccc ctctcccgct cctctgcttc ttcctccctc tcatgccaag gccaggtcct

33961
cccttgccag tcctgaaggg agatgtcaca aaggccgttt tcctgagaca ggccctgccc

34021
acactgggca gtgacccgcg gtgctggccc agtgtgccca agccctccaa gtccccaggc

34081
tgggagaagg aatctcagct ttgggaatgg caaacgtgca gggtgggctc acagaagcct

34141
cctcccgagg gcctgctcag ccagcaacag agtgctccaa gtcatgcatc tgctctgagg

34201
ccgagttcct tgtttataga gcacagaagc cattacccac ctctccggcc attggaaaga

34261
ctaaatgaat gaatatgcac gtagagcatt cagacctctg cataagaaaa agttccccag

34321
aaatggcagc gattattact attattattt attactggac tattgagcag tctgaatttg

34381
gtagggtata aaaatggaac taaaaaataa aaagtcactg ccttctacca gatctgtcaa

34441
aatcctccct gacacggtct ctccacagcg tcttgagcag acctcagcgt tgtctggtcc

34501
tgtccagaag ggcttcctac tccagtctgg catcctgttc acccctggcc atcctccttc

34561
cctcatgctt gtggctcagg atgtggagtg ggacagggac ccctgctgag gccctccaca

34621
tcctcccctg gtgggcagcc catggaaaaa ctgtcctcat atcactctac cccacttggc

34681
caatggagcg caaatagatg acttgccaca gccaacagtg gcaggctggg ctccttgccc

34741
tgctgtactc tatgggtctc ctgccagtcc actgccctgc agatgccact ggggatttgc

34801
atgccatgct gcccctcttg caggtatcta atcaccatga gctgtttccc caagaagtac

34861
cacaaaaaca ctacgcctag gacagaattc ttcccacctt tcccttgccc agtcttcttt

34921
cccatcccag gaaggtgggc tgggtgatgg ttggaggtaa cagggccttt gaggaagccc

34981
taggaagatg tctggctctg cccattggca gctttttaca gaatggggca ctgggccact

35041
ttagcctctg ttttgagcca ttgttgccac ttctagggca ccaggaaaaa tcccaatcaa

35101
attcctactc atcattaaca ttgagttagg gaggaagcaa cgaagaagtg gtaagggtga

35161
atctagaaac aatgagttgg ggacaggctg tgggcctgac cccaataaca ctaatcagct

35221
caaacctgtc cccagtgtta ccactggcag agtgaggagt ggtttgaact caacacagga

35281
gtctggggca gagcctgtgc cagtcagggt gattctgatg agagagagct ggaagctcac

35341
agctccattc agcacccacc aaaaaccagg ctcacaccca cattccttgc tgtctccctg

35401
ggacccgacc accaccctgg ttgcaccacc ctctcccaac ccccctcagg agctgggagg

35461
ccatggaagc agcgctgtgt agggagtcaa aagtcctggt aggtccaggc tcttcaccta

35521
ccacatgacc ttgggcaggt cctccaacat ctctgagcac catctttgaa agaggagtgg

35581
gcaacaatgc cggctctaca aggtggttgt tggaactaaa tgagattcca ggtgtcaatg

35641
ctttgtccct ggggagcact gggcccaagt gaggggccac tctgactgtt ggagatcccc

35701
acaagagatt cccctcccac accccacggc tcctacctgt tattgccacc gaagccgcag

35761
ttgtccctct ctccccagac atttcggtgg ccggtggcca gcagcatcga cagaaatgag

35821
atgctggaga ttcaggtttt caactacagc aaagtcttca gcaacaagta agtgtgggat

35881
ggggcaggag gggctgggcc tggacgggct gggagcctgc tcttctcctt gggctaccct

35941
ctgtttgggg cttaaaaagg ggacctacac tcccaacctg ccctggattg atcttcaaag

36001
accgaagaaa tcttgggctg gtctttgatc cccattttga tccctcttct tgtcttcaga

36061
atcccccagt tctcccagct gctgtcagcc aagaacactc caccctccta tcacctctgc

36121
tgtctccaac cccatcaaag cttcctgtct taaagactta aagctttaag tctccctcaa

36181
tgccacgctg gggtacagtt acccactgga gaggcgaaag gtggaggggc tgatgatctc

36241
ctccaagaga cactctgtag ccctgagggc aggcttgaca gtttggggtg gtggtttagg

36301
agtcaggcaa gcctgatctc agacactcag gtcagtcatc tactgtgtga ccctggaaag

36361
gttacataac ctctctgatt tcaatgtgct catgtgtgaa aaggacaagt atttacctca

36421
aagggcagct gtgtgaatta aatgagatag atattcactc actcattcaa caaatgttta

36481
ctaagcgtcg attgtgtatc aggtactgaa ttaggtgatg cagagggcgg ggtgcctacc

36541
ttcatggagc ttgcactcca caagtgaagt acacctgcca tacgagcgtt atcactataa

36601
ggtgttcaat aaaagtagtt gtcatccttc tctctgggcc atgagaagaa ttcagaagga

36661
tttgaacacg ctggaacagt ggctaagtaa tatcttgggt taaaaaatca cagccaggtg

36721
tggcacacac ctgtagtcct aggtccttgg gcagataagg cgggaggatc atttgatccc

36781
agtaatttga ggctagcctg ggcaacatag tgagatccca tctctttaaa aaaaaatcgg

36841
ttgctcttat acaagctgga ggtcatggct taactgtaac atgtccaaga aggtatggag

36901
gtgttagctc actgaggact cagaatgact caacagtggg aggagactac aaacaaaaga

36961
aaagtaggcc tcatcctaaa tcatactaat agaattaaag cactcctgat ctgagcagga

37021
gagacaagga gtccactgct ctgatactag tggcagagaa ttcctgtagg caccacccta

37081
tagtttccag gaggaaaggg actttaagtg ttaccttata acaaatggat gagagcctga

37141
aagggaaaat catagaggac atattcatcc attcatccat ccattgatcc attcatccat

37201
ccatccatct atcattcctg ttattcatcc atctgcctat ccatttgtct gtccatcaat

37261
tgatttatcc acccttcctt tctttcatcc atccttccat cctttcatcc atccattcat

37321
caatccatcc ctccatccat ttatcaattc atttatccac ccatttatcc atctatccat

37381
tcatccgtcc atcctttcat tcatcctatc catccactca tccatccatc catccatcca

37441
ttcacccatc cttcctttca tccattcatt catcaaccca atccttccat ctttccatcc

37501
attcatccac cacttaccct ttcatccttt ccattcatcc ttccatccac tcatccatcc

37561
attcatccat ccttccacct tttttctttt cctttttttt tttttttttt ttgagacaga

37621
gtcttgctct gtggcccaca gtggagtgca gtggcctgat ctcggctcac tgcaacctcc

37681
gcctctctgg ttcaagcaat tatcctgtat cagcctcctg agtagctggg attagaggtg

37741
ctcaccaccg tgcccagcta atttttgtat ttttagtaga gatggggttt caccatgttg

37801
gccaggttgg tatcgaactc ctgacctcaa gtgatctacc ctcctcggcc tcccaaagtg

37861
ctgggattac aggcgtgagc caccactttt ggcccatcct tctatctttc cattcactga

37921
tccatctatc gatccatcca ttctttcatt ctttcatcca tccttccatc catcatcctt

37981
ccttccatcc attcatccat cctttcattc ttccatccat tcatccatcc atccatcttt

38041
tcacccaact ttgcagtcac tcatcataca tatagtgaac aaatgctttc tgccagtcag

38101
acactatgct agtcactgga gatactgaga tgaggtattg aggcacagtc cctgccccta

38161
ccctcccaga aggctttttg ccacaggaag aggaaagaaa ggtgtgtacc tagaggcagg

38221
atgaggaaca ggctgctgga agacagcaga caactgaaag atagccagta ttttccagcc

38281
aatgtgctgt cttaggaggt agtgagctcc ttgccactgg gagagggtga gcaaagagtg

38341
gaccacattg tagaggggat ttctgagtca ggaaaggccc caccatatgg gctccaagga

38401
gtctctgatt ctgtgggttt tattaggagc tttcaaaatc tcagctgagt atggggcaag

38461
ggcatttcag aaatgctgtc agggccacag ggaggatgtt tagtgcacaa aggccttccc

38521
tttgcctctc atggcatcac accattcagg cagctgcttt tggcacccac aagcaaggtt

38581
ggtgagacac cccccaccag gggcccccaa ggtgaagcag agccttcttc cctggggtga

38641
gataccatga gggtgtgacc tatgaggaca ggagaaacag gaacaagtgg aaggctcaca

38701
cacagaccaa gtgggtgtga aaaaggaagg agaatcggaa gtcaagcacc agggagggca

38761
cctgagagcc cctgaaggaa cccaaccata ggtgccaaag catccaggag ctttacagct

38821
cagccactac agccctagct gtgcaggagg ggaaaccaag tctcagaggg gaacctgagg

38881
tcacatgggt agacaatggt agagccaggg ctagaatgca tgtctgttaa cttctcttcc

38941
taatccaact cccagaaacc aaaatatttg agcagtgatg gtggaaactg agggcatgga

39001
agacattgtt aaatcattta taatgaaagc caccagccta accactgaaa tgctggaaac

39061
acttgagccc atcaaaagac tgctacaaac aaatcagaag tatttgggaa atcgggaaat

39121
tgactcccat gcagtgaata tgttgaaagt tacagcttct attaggtgtt tttggttttt

39181
gttttgttca gagacagaat ctcactctgt cacccaggct ggagtgcagt ggcctagtct

39241
cggctcattg caacctctgc ctcctgagtt caagtgattc tcatgtcttg gcctcccgag

39301
tagctgggac tacaggtgca tgccaccagg cctggataat ttttgtattt ttagtagaga

39361
cagggttttc cccatgttgg ccaggatggt ctcgaactcc tggcttcagg taatagacct

39421
gcctcagctt cccaaagtgc tgggattaca ggtgccagcc accaaatcca gcctgtatta

39481
gatgttctta agtgccaata agaaggaaga cagaaagggg aatagttcct atcctaactc

39541
tcctcttctt ccctccctgc ccccatccaa gagaaggcag gaaaccccac aaggggaggc

39601
ccaggcctgg tgggagaggt tctggcattt ctttggaagc ctagagaatg cccagggcac

39661
tgctggctgc agagctgaga tgggaaagaa gaggtcccct tgtggagagc acaggcccag

39721
gctgacacag gccagcttgt gggggtcaga gtgggagaga ggtgtttgga atgatgtgag

39781
actcaagtct ccccatcctg gcatttgcct gggccaggcc agaggagcaa tgaggccact

39841
gccctcaacc cccacatggc ccagttcaga ccccaggctc cttctcatgg ggcagctgag

39901
tggaaggggt ctttggggtc tgcactaggc ttagcaatga gcaaagccat ggccactgct

39961
ggggacagtg cctggcacat ggcaggctcc tgattatttt gtggaataaa agaatgaata

40021
aatgcccctg tggtgttagg aggcagaggg taggtataca aggtgggaga gcctttgaga

40081
gggaatcgga gtggcccctc ttctctgaag gactcagggc actcaagggt gacactcagc

40141
atcacatgac cgatgcattt ggggaaattg agctaaaaga ggcatggagg agctgcctgg

40201
gagagtgggt cccaggacga gaaatgagcc tgatcccatc actgccatct cagagagaga

40261
gacttgtcct agaagcagag agtagcttgg aaactggccc ctcacccagt ggttctagag

40321
gctgccagga ggcagagaca tggtatgaag gaaggaggca tcctaggcag aaaccaggag

40381
acctccaggt ctgcttggcc ccgtttggaa caaagacctg tgtccaggaa ccttgggctt

40441
ccccatgaga aagaaatgtt cggttcagaa gattttgtgc atccagctct gcctgtccgg

40501
gacctctgag ggtccatggc ctggcctcca gcctcctgcc tgctaaggat gccagggacc

40561
ctgaataatt caggagccag gacagcagga gaggcctcgc agggcccagg acacctgaca

40621
cgggctccca ggggaaagtg atgaattatt gacaggattc tggtgcccag ttgccgctct

40681
attgtgatca gtctgtgggc ccatctgggc tggaggcctt ttcctgccgg ctaattacgt

40741
ggggatctta gctctgccca gccgcccagc ccctcgtggg gccagacagc ctcctgtgag

40801
gggtgtcctc tttgccatgg tgacctggat ggccctgtaa ggcaagtagt cagaggacat

40861
ggagttagcc ccagatcctt tgcctgacag ccccagggaa actgaggccc agagaggcct

40921
cttgtccagg gtcacacagc aggttcagga cagtcaggtc ttcaccccag gcctcctgac

40981
acccgggcca gtgctccttc ccacagaaca catggcctca caactccatt tctagggaaa

41041
tgactcagct gtctaaggag catatgagcc cacccttcct caatcgtcct gggccccact

41101
ctcccaggca gctcctccat gctgacccat gcagaggagt aagaacctac tatgtgtgca

41161
gccaggatgc acaaaggcca gctgcggcgg gcagggtcgc ctctggggtc accacaaggg

41221
ccagagccag gggcttctcc tacctcttcc tgtcccagct tcttcccaaa gaatatctat

41281
agaagacggg ctgagggatg gcatcctaga agcagtgcca gggcctttgt tttgaaactg

41341
ttttcatggc aagcactgtg tttttgctta aatggtatgt tacagacctg tagaaagagt

41401
caaggtttat aaaactgctt ttctttatac tttacataag gctgagataa tatcaattgt

41461
ccatgtcaaa aaatataatt tttactttta tttgagagag gttggggggt gaactgttag

41521
gagttaaaac cccccaagcc actcttggag gtgtggcaaa ttgattcctt taatcttgca

41581
agctcctagc gtcccagtcc caccctccag gccatagaca agctctggct gtgcgaggct

41641
gtgcacagct tgaagggtgg gggactgcct ggacctgccc ctgaagccca tcctgcaaag

41701
gagactcgcc ctgtgtaggc tctccagatg gccagccctg ctcattatta gggagggagg

41761
aggggctggc atccgagtgc cggtgttggt agaggaattt cacatgagca gtctcctcac

41821
cactgtccgg tggaagtcgg agggctatag cagaaggagc caaaaccaca ctgctgccag

41881
gaggtggaat ctcccttggg tcctgctgag tgagcccaca tctgtctgac tccagagccc

41941
aggctcctca ctgtctacac cgcttccctt tagggatgga attaatctgc atgtggacag

42001
ggcttggacc agggtaggaa gagtagggga tttgcctgga ggccaatctt gctcagcaca

42061
ctgtgtgatt aaggcagtgg ctgaatggac taccagtgac agccccatca ctgtcaccac

42121
caccggagta tctagcaggg acttaaaagc acatgtcagg gaggttgttt cagggattcc

42181
tcctggaagg ggcgctggac aaggtctctc aggttcttcc caagtataag atctgagatt

42241
caggcaggtt aagcctagaa ggcaccagac gcctctgtga gcacttgcag ggggaatagc

42301
tccaccctgc cccctgggag tgtcttgtca cattgcagca cctctgcgga tcctggggag

42361
ctgccttggc tgttcttagg catctaattc tggagaaaga tgtgcctgat cgccccacgc

42421
tcaacaggtg ctcgacaggt cctaggggaa tcaaggcagc tgaatagcca tccacaaagg

42481
gtaatagtag agcagggatt ctcaaagtgt ctccccagcc agcagcttca gcatcacctg

42541
gaaacttgtc agaaatacac attctcaggc cctctcccac ccactgaatc agagccctgg

42601
ggtcggggcc agtggtgtga actgaagtcc ggtggaccca gtttggtgac ttcacattag

42661
aagcttgaag ttggccatgg cgggagtatt tatatctcag aaaccagcaa atgctacaga

42721
tgagcacctc tcctctccca ccagtgacac attttccagc atatccacag aagaggatat

42781
cccagccgtg catgttttca caagccctcc aggtgattct gctcatgctg aagtttgaga

42841
accactgatt tagaacaaaa aggggtgagg ctgcaaaaag atgagtgtat tttttcgtgc

42901
ccgtggtcta ctgttagaat gtctacatgg tacggaagct aaaagtcccc ttccctcttc

42961
attttataaa gaccaaattg agactcaggg gcagcagctc cagggctcct ggcccccagc

43021
ccagcacttc tgtctctggg gcactgcctg agctgggaga ggtgcatgca gctatggaag

43081
aaggcttcca tgggctgctc taagggccca gaagcccagt tcggctttag agtgaaggag

43141
tggcgtggtc agtttcatcc tcagggaggt ggggcacaat ggtggttggg gctctgagct

43201
ccaaagggga gcatttcata tccattcctc atggctgccc ctaccacttc ctcccctcac

43261
acagatggga agatttttaa aaaatcaatg ttcaccctcc acagacctca gggtggtaga

43321
gacatgaagc atgtctgagt cagaattcat ctgatacctc acctcaccca gatctaccat

43381
taattagctg tgtcccttcc ccttccatgg cctcactgtc ttcctctata aatctcaggc

43441
agcatcagat gatgcccaag gtcccttcca gctctcacac gccctggatg cttccctccc

43501
ctttgtgcct tcagctagaa atggtgtgtg tattctaatc cactctatgt ggaagcacca

43561
tgtaagaacg tctgtctgag ttccctgttc tctcccagag caacaaacag ccttctgact

43621
gtggggtgca atggggttga agtcaactcc atcagcattt attgggcacc cactgttgtt

43681
cattaattca gccagcagat attgagatct ctagtgtgct agaaatgtca aacagaggct

43741
agaataaaaa gcaccaccca tgcccttgag aggttcacag tttagaggca gtacatgaat

43801
cacgacaaaa cggactgctt tggagtgctg gctgtgtgct gggggctttg acaagaacac

43861
tcgcagatga tctcattcag tcctccaaca acaactctgt gaagtagggc ttatcagctc

43921
atcttatgag aaaaccgaca ctgagagagc ttaaggaagt tgcccaggaa gcaggtagct

43981
tgctagtcag tgtcagagct gggttcagat ccctgtctct ttgatgccag gactgtgctg

44041
ttaaccaaag cattgcaccg cctctcccct gctgtgcagt tccatgggct ctgccatcac

44101
acaggttcct gccatccagg aacttacagg ctgcagatgt ggaatggatg agtgagtgct

44161
gttggtgtgg gctggaaacc ttggtcatgg ttaggcgggt agaagccgga ggagctactt

44221
gtccatccag gaaactcagg tcctttccca gcctccacac tgagcatctg gaagcttctc

44281
tgcaagggct cagctaaagc tggatttcat gcacctttcc ccgcagtctg tagacatccc

44341
ctaagggtgc tcactgcccc ttggagctct cccaaggaaa tgggcctccc acaaacaacc

44401
atccacagtg ggacatgctg ccctggctgc aaccagtcct ggctcctggg ccaccttctc

44461
cagcccagcc cagagctgga gcaagcccac ctgagtcctc cccaagcagt cacagccctt

44521
gggatgtcag tcttgctcct caccctggtc tcttccatgt taccaccgtg ccccctctgc

44581
catccccagg ctcatcggga ccttccgcat ggtgctgcag aaggtggtag aggagagcca

44641
tgtggaggtg actgacacgc tgattgatga caacaatgct atcatcaagg tgggtatgcc

44701
ccacggagtt cctggacttt cccatatggg gccatctggg ggtctgttct ccctgcctca

44761
cacatggggt ggtctgggga atgcctctca tgcatggcga ggtgtcgcag gaggaggaga

44821
ctcaggtcag actctgctgg aatggctcaa tctgtggcca tggctggagg ccctgtggca

44881
tggcagggtc tgctgcccca cagtaggcac ccctgccctt cctacggtgg gaatgcacca

44941
actggtcctt ccatttggac ccagctcagg agtcactaaa gaggctcctt ttgtcatcca

45001
aaggccagac tgagccctgc tggcactcga gggcatgacc ttcactctgc acatctggct

45061
cgggtcctcc ctgggagggc agggacctca tttcctattg tttgtcacat cccagcactt

45121
ttgcgtgagc acgcgtgcac tagtgatgca cagtctagag gcacctgaca catgttctaa

45181
caaagaagga agcaacccta ccaggacagc ctggccccag gctctgctct gattcttcag

45241
tcctcttgag ctcagccgtg gccactcatg ggcagttggc atgatggtga ggaacaggga

45301
ccctgagtat gaatcttagg ctgctcacta actgtgtgac ttaggcaagc tacatatcac

45361
ctcaaagtga gcacaattac attatccacc tcccaggact attctgagga ttaaaggaca

45421
atacacagaa agtacttagc acagatatgc acaataaatc tataatattg ttagctatta

45481
tttcctgacc tcagtttacc tatgtataaa atgggactgt gccatggtcc cccagtgggg

45541
tcctgtgtaa tatatggccc tatgtagtgg ccaagagaaa cagcctcaga agccaggact

45601
gcagccacag ggagctagaa cagaaggaac cctcttctcc catgggcagg ggtggcaggg

45661
agggcttctt aaagttaccg gggtctcagc caccacagca aggggagaag gggtgcagaa

45721
taagctatgt atggacaccc atgggaaggc gggctgggag gagaacacag aaacctggat

45781
gaagagtgta gtgtgggaag tgagataaga gaattgggga gtgagcaggg atggacagac

45841
agcacagccc atgccctgga ttttcagaat cagacttaag atgtcagcag aggaaaggac

45901
tcacggatct cctagcccac ttgccaccca tctccgctac ccattgttat gaatgggaac

45961
aatgaagtcc tggatgggga atggattcgg ccacagttga cagcagggcc agcacggaga

46021
cccaggactt ccaatgccag agaccaccat tttcccataa caacatactt ggttccacca

46081
agagggtccc atttgttcca gaaaggacat ggggcttgga gttaggcagc ctgggctcag

46141
atcccagctc cagtacttcc tagctgtgtg acttaaagca agtaacttaa cctcctgata

46201
tgctaggtaa ggtaggttgc aatgttgaaa agatcaaatg agtgtacatt aaagcatctt

46261
agcatgatgc ctagcacagt gaggattcag aaaatatgtg cacctttccc ttcccttggg

46321
aaatctaagc ctgggtgctg gagcatccaa gcactgagtg agggccgcct gtctggggca

46381
caggaccaag tcacctctag accagtgagg aagggtgatc cctgtgcact gggggggaaa

46441
ctagagctgc aagaaagtaa tggctccagg acgcagagca ggaagcccaa tcatgactct

46501
ccactgctaa gcctgagccc ggttgagtgc tctacttttt gccagaggaa aaccctaggg

46561
cagctcccaa gattccctcc ctctccaggg taggaagggt gagtgtgagc ctgggccctg

46621
ggctcctctc ccggaggcca ctttcagctc attctgtcca tttccaacaa gccgatttct

46681
ggcgggccgc gcctcatgcc tgcaggcagc ccttgttctg aggagaggag gtggcctgat

46741
catggggatg ctgaacgaca ctctcggtta tgtagacagt ggactcgggg ggtgagtcca

46801
ggctcagttg tcctgggcag gccaggcccc tccaccttga gcaccaggga ggagtggaac

46861
caccagcagc gggacctgga gccaggtacc agtaagctga cccggtctgc acaagtcagc

46921
ctttcagagc ctctgttttc tcatcagcaa aatggggcag aggggatcat accatcctga

46981
cctcctccag tgaggcaagg gtgtggaagc gctgtgtaaa caccaccaag cagccacata

47041
tacggggtgg agattgctgt caccatccca gctgctcacc accgcctccc tcccttcaga

47101
ccagcctgtg cgtggaggtc cggtatcagg ccactgacgg cacagtgggc tcctgggacg

47161
atggggactt cctgggagat gagtctcttc aagaggaaga gaaggacagc caagagacgg

47221
atggactgct cccaggctcc cggcccagct cccggccccc aggagagaag agcttccgga

47281
ggtaacaggc aggacccctc tggctgccca ctgctcccaa gacacgggga agagacctgg

47341
ggcctggtcc tactgacagg cctctctagg cctagcbggg ctcagagtac agggctgagc

47401
ttctggagag acatccaagg ggtgggaaga tgtttctgta gccccccacc cagccgtcca

47461
cccccgaggt cactgggcag ggagcaggag actcagatgg agctgcaagg ccaaggcctc

47521
cccagtggcc ctgagggagg tggagctcta acacagggat ggggctagat ctcctgcctt

47581
tctcagagaa ggggagttgg ggataggagg gcccctggcc tctctggttc aagacccagc

47641
agtgtccacc aggtgccggc agcctgacct ctaccctggc ccagtgagga ggcccaagag

47701
agggcagctc ttcctgccag agtgaagcca aagatcctgg ctgggccctg gcctttcttc

47761
ctcttgagaa gggagggtac ccgggaaccc ccagaatcca gcgtcacgcc ctgcaagtgt

47821
cctgccacct atggatcaca ggaagctgga tccaggacag ctcattccac gtgcactatt

47881
tttacaaaac agaaaatgca attgtattac tattagagac caaggggaca gaatctgggc

47941
tagtctagta agatgttgtc catgggttcc taagtcacta ggaattatgt gttaaatgcc

48001
agtaagtcaa gggtgcatct gaaggaccag ggtgtgtttt gagaagggac cctccgtgcc

48061
actggaaaca tatccctgta agctccttcc acgctttcct ttccaagtaa agtttactca

48121
gtccctctgc tgaagaaacc ataggttcta aattagtgta attgaactga catactttta

48181
tgggacaaat atgttttctc ctttgcactt gaatgagttc acaccccctt aagcacccct

48241
cacacacagg tgcatgagtg cacacgtgtg cacatacaca tacacacaca cacacaagct

48301
tcagaaaccc tgggagccag atgagtaata gtaacaaggt caaagtgacc aggcctgcaa

48361
caaacatggc gggactgtct actccaggcc agccacgggc atggggcagc cccaggctag

48421
cttaaagcct gtcccctcag actcctggct ctttagcaga aaacccaggc ctgagtccta

48481
gctctgcctc ttactagtcg tgtgaccctt ggcaagtctc tgaccctctc tcctcacctg

48541
caaagaagga catagcaagg aaatccccct gccctgctgc tgggagagcc ggagggatca

48601
cagaggaaca ggtggcaatg gaggtgctga gcgctgccca tgtccaggct ggtgacagac

48661
aaacaggttt cttgtagcac aacaatgcaa agagtcagga atcgggttgg aaattgtgag

48721
aagaggagca gtgctcagac ggggagtgaa gggatgctga ctcagtgggc accacctggt

48781
cctcctcgac tgtctccatt cagaaaagag gttggcaggg ctggtccaga aaccagaagc

48841
cgggctctaa gaaagagctt ccagagaaca agatcggaag ccacacaagg gccatcagtc

48901
acagggaaag gaatgctgac cccaaatcag gagagctaag gcccattaag tcccatcttg

48961
actgtgccac tcattggctg agtgacactg ggcatgtcac cagcccctgt aggtcagtga

49021
caggaatggg ttcagcaagt tacatctggc tcccctccaa ctctgaggtc ctaagggacc

49081
catggatgct ccggacctgt gggtcacatc catgggaaac aacatcctgg gagcccttag

49141
cagccacgaa ggcaacctcc ctggggtggc gtagcaacac agagccagtt tctcactcag

49201
tcctaagaga gtgggccagg gtgctgatgg gggctctgga gagcttagag tcccagagag

49261
ccctaggcac caggaatctg gagataagag ggctcccccg acccttcctc acagcctggt

49321
ggcttcccca cctctcccca tcttcgtgtg gcccctccca gggtagcagc aagaagcggg

49381
agcaaaagga ggggcttcac cccggactgg gaattgggag agggtgacag ccgaagccag

49441
gcacccccac cctgcattgc aggggcagtg tgcaggagca cagtttccct gctgccactg

49501
gggctgccag cccaggtttg agagcacatt ggggacaggc atcgctgcta caccttctcc

49561
cgccaggcct agccatgcag ccagcaggcc tggttgtgga aaagaggggt tgagaaaaat

49621
tctagagatg ggccatttgc tggtgaggag aaggtggagc gggttcaaga acttggggtt

49681
ttcctgtagc ttaatcctgg ctgcccatat ggggccattg agttctgggt caaggagtgc

49741
tgaggtgagg agggggacct ggaagctggc cccgcagccc tagatgttgc atctcaccct

49801
tgtcacatag tgtgggttct gggaggaagc cagagagctc tccagaaggg acttggccaa

49861
ccttttatca ggaaaacacc tactccttaa agaggacaac accggggaag gggtgtcagt

49921
gcctcacctc tgaccccgtt aggagcccag gcaggcttcc cctgcatctg ctccctgccc

49981
tccatcctct cctgggaagg ccaatcccct tatagatcag ggtattcaat aaccacagtt

50041
ccctcttgtt cctgctttag ccacaatgag caagaggaaa atcccgttgc tggcaagcag

50101
cagtgtctca ccggccatct tgaccgttag ggtccggcgt ggggatcagc cgctccctgg

50161
ctgatggggt gaaatgaagg cctgctgggg gctgcgggga ggtagactga gtgggcagga

50221
aacagcctca gcccagacag gccccgggca gcccaggctg gaatcttcca cggatggagg

50281
ggaggctgat gccaggagat cctctgggca ctcctcacct ctccctccag ggcctgggtc

50341
caccccccag ccctgccctg cctggcctgc ttctctggga cttcacccac attcatcctg

50401
tcctcactct gggggtcaga tggttctaag caggggcagt gtggacctca ggcctcagct

50461
gctgtgacac tcactcctaa gaccctaaga atctgccatg aagttacccc gttcctcctc

50521
agggaatcag tatgggggct ctgcctgaat gaccaccaac cccaccgccc actgactctc

50581
tgccccaacg attccacctc ccctaggccc tggtcagccg catgccctct gagccactct

50641
gcccacttct ctagttcctg ccacgaagcc ctgatttctg ccggcttttt gcacaatgcc

50701
cccggtaatg tgccaggaag ctgtgctgtg tgacagagca caggctccac tcacagctct

50761
gctattggga acccccctcc ccatttgtga gatggggctc aaggatgcct cacagaagtg

50821
ccaggattga gtgaggtgca cctgcgagtc atccacccct gtgcctggca tgtggcaggt

50881
gctcagccag tgttcacttc cttcctcttc actgactcca tgttaccctg atgtcaactt

50941
ctaccccgag cagcacctga ccctcttgtt caggtgctgt ccaagcacct tctcagctct

51001
tgctccccac cctataccaa gggctctgca gaagctgccc acacaggagc cttactggcc

51061
caggggcagg tatagggagc tcatttactc aaagttcccc tcacctcccc aggctctcag

51121
tgttgcagag atgtaatgaa tccctaacct catgggcgct ccactctcag cagcacaaaa

51181
tcagtgttcc agacccttgc atggcagcgt atgcctgccc tagtctctgg agagaaagtg

51241
acttcggccc tgaccacact cacatgcaca cacatgtgta cacaagtgcc catgtgtttg

51301
cacacactca catgcactgc atgacaccag ggaggactct ggattctggg ctctgctgtt

51361
gatgctgtct ttaggagtca catcttagag aggacaaaga aagaaatccc agctttagtc

51421
ttgcagctaa actgtagaga cctgagcctt tcctcctgag tcccagtatt ctgcgactat

51481
ctcctcttct cattttctcc acctggcctg gctctcctgc cctccacgac ccccacctcc

51541
ttctgctgcc caaaccctct tctgctggtc tcctctctgc tgggtctcat ctgggaggag

51601
tttggggcag gagccacttt tctcattctc cttattgatc attcttccac tccagtggag

51661
gcctgcagaa gccaggtaac ttcctcctat gctggggcca gagggcagtg gggcacgtgt

51721
gcatggtggg gctctgagac agaggggcag agagtgggca tgcagaagtg tgtgcatgtg

51781
gggccagtac atgcagcctt accccaagag tgtttttaaa tcggtttcca cagcccctag

51841
agagctagaa aatcctctgc tgccttcctt ctccaggctg agccccagag ttgcagcagc

51901
tcccaaagct gctcagatga gccggggcag ccgggcgcac tgggattttg tgcttgagac

51961
acattcctcc tcctatgctg tgagctcttc tccgcttagt agtctcagct gatgtgggca

52021
gccgaggcct ggctgatgtt aacacctttg aattacagac tgacctgctt gcccaacgta

52081
aaggttagct ggccagcgct ggactgcagc tgtgctgtgt ctaggccttc aggtcttgag

52141
ccatcaggat atgcagtcaa gtctacctgg gcaaggcctg tgccagaaca gggtgtgagg

52201
agaggaataa tttgctaatt gttattcact ttcctgtctt catcctcatt gccacagcac

52261
tgggaaagca ttgagagaac attccagaaa agttttctgg aagcctccct aaagtgagat

52321
aggggggccg tttttccctg ctctgagccc tggagtggta gctcacttac cgccccacct

52381
acacccctag aactgccccc aaccacccgt gtgcactcca tagcaggacc cccagccctg

52441
cctcaccctc acagagcagg cttagcccac tgttccccta gaggccccca gagcctggga

52501
gctcccaccc cattggaggg gagcagggga gcaggggagc cggtgggcag aggagcaggg

52561
tggcccaggc cgggagggtg gccaggctca tctaaccctg tgttccctga ggaagctgcg

52621
acccacattg tggaatcatc agatcttagc ctggtagggg cgatgagctg aggccctgag

52681
gtatcagagc ttggggttgg aatagtggcc acccaggccc agcactgtgg gcccctccca

52741
tctcccccaa ggcagaaccc agggccatgg gacccctttt ctgcagacct aggcttgcta

52801
ccgtgcgaag ctgtggggtg agaggtctgt gggacaagga ggcccccggg gagcgtgcag

52861
gcccgtgggg ccggggctga ggccagtgtc tctggtccac agcccctcac acgtgtcccc

52921
ttgtctcctc atttcttccc cctactcagc aaaggcagag agaagaccaa gggaggcaga

52981
gatgacgagc acaagtaggt gtcccaggcg agggcagacg caacagcgtc tctggggaga

53041
cagaggcctc ctccccacag gctgtggagg gcgggatggg ctcggctgag agggctcagg

53101
agtgggctgt cgtggtagag ctggcacggg tcatggaggc ccagggaggc cttttcacct

53161
ggccacgggg gtgagggatg aggaggggtt agggtcgcgg gggaggtggc cagaccttct

53221
ggtttccact ctgggctctc gggggtgacc atcctcctct ccgtgtcttg ttcctcctcc

53281
actgttcagc ccccatcctg tggccttcgg gcttccctgg gagggagggg acagctaaag

53341
gctaagggga gaggggcatg aggacctcag ggatccctct cccaacaggg gcgaggtagg

53401
gccaggcagc tggaggcata aggaggagga actctgggta ccctttgcag ctgcaggtcg

53461
tgggtggagt tggagacccc cagaaagctt aggagaggcc accatttggg cggccctctc

53521
tatcttcatc tccccaaaag gcttcctgga aaaatgaggt cagggtgctg tctggagagg

53581
acaggagaag ggtcctgcag gtgggagggg ctggtcacaa gggtctggaa agattcgaag

53641
gctgggagtt gtgaatgggt cttgtaggca cccctagaag cacactgaca tctggaggac

53701
tctagcatta cgggatctca taagggcagt ggtagccaag gtggaccata ctggaggagg

53761
cctctggtta acacctgctc ttacagatga caaatctgtc tcagaacagg ggcagagctg

53821
gaaccagaag acagggaagc tgacttctga cccagagctc accatagacc caggaaattt

53881
agagaacttg actgtatcta aatttaatct aattctccaa acataccaat gagagctgaa

53941
aagccaggag tgtggtcttt tttatcttcc agataagcaa cctgagcccc agagatctta

54001
agagatttgc tcaaaactgt ggcctcaata tattaagaat tagttcatct gaagatatca

54061
tggaaatatc aggattgtgt gttgaggggt ctgaactgat caacactggt gtgggcttgg

54121
gatatccact ggcattaaga tcctggggaa ctcacagcct cattcattgc ttcaaaaaaa

54181
ggtatgagtt ctaactcgca tttgttacgc acaagcaaaa gcaatgatga tgcagtgtta

54241
actctgtagt gatggaggaa atggcgctgt gtaggaagag ctccagccca gagacctgaa

54301
ggatggagga gtttgccagg ttcccagtaa gggaagacac gtaggcagag catgtgtcaa

54361
ggctcagagc cagggaactg aatccagggt gggtggcgat gatggggaat gctgagctgg

54421
ggagtcctct tagggagtcc tcaagggttc aggtttctcc atagatgctt agatgtaaag

54481
ggcatatgaa tgagatacaa gcagcctgtc catccccagc ttctctgcct gagatcagcg

54541
atgctctaag gcccttcttg atgcccagct tcccagtctg tcccaggcca gacccacagg

54601
gacacagact ggcctgatcc ctttgactgg ctacagttgg agtaagaggt acctcacagt

54661
gccagcacat agtaggtcca ccaaaatact ggtttcctag cacttctctg tcctaatttc

54721
ttaccatctc taattagcac atgagataaa gtaaactggc atatagtatt gttattatta

54781
ttatgtgtag agcaatagga ctattgaaag aataggaaaa tgagatttct aagaagagat

54841
tgaacaaatt taaactcttt agcctggagg agagaaaact gtggagacag atttcaatct

54901
ctgaaatgtt aatgtgtggc aaagctggtt ggtatctatc tccactgaga agagataaat

54961
ggaaataaat ttaagttgaa gttaagttga agtagagaaa caagattcaa cccacgaaag

55021
aactcatagt gtgtgacatt ctgggatagg ctggtttggg gagatgagaa aacacccatc

55081
atcttccatg atgctgcttg cttgagcctt gcaaagggct gggccgccag caagaactga

55141
agagccagct tccctgacaa tcctggggtc aggacaagtg tgtgtgggtc ccccaagcct

55201
tctggtacaa cgtgggcaca tgtgcaaacg ggccagtttg gagacagggt ggttcttgta

55261
taaagggtca gcctatcctg cccacctatg gaaagctatt caaaaactaa ctgacattca

55321
acacactttc aaagacacct gtaaagacca aaattatgaa attccctgtg ccttggggca

55381
tggaaaattt ttaaaataaa cccatttagg ggcgcttgga taacatgctc cgaggttttg

55441
aaaattgggc tgtttgagca atgcaaagaa ggaccacaga ccctatttct catagacagg

55501
agtctttatc ctgattgatt acctgaggcc tgagctaatg agcctagtag ttccagttga

55561
agccagtcat ggggcagaag ccctgggcag tgaatggact cgacctgcag ctcatttatg

55621
gtcaggtctc tattagcttt cagaataatc cagagacctg aattaatgaa acactcgggt

55681
cactaaattt agtttggtga atgttcccaa gtcattatga atactaagct ctacctagga

55741
ccctgtgtgc accacacagc aacacgcttc taaatctggg ccataaaatg agcggagaaa

55801
tcatcagatt tatagtttac aataagtgaa ctaattttag catttttttc ctctagagat

55861
aaataccagt ctagattgta ggtgcatttc attctgacca tggtgaatgt agccacagga

55921
aactcaaacg gattctaaat cctcagaggg tcctgggata ctggcctccc cttggctctc

55981
acttctcaag ctttaatacg cccaagaata aggagccatt tgattgtaaa gtgagttttc

56041
actgagttga ttattggctt gttttctttg tctgtttctc accatatcct gtttttggta

56101
attgtagaac tcaactagac caaatgcaga attttacttt gaaaacaaaa aaaggccagg

56161
acaacggaca cctcaacagc aaattacatt ttttgaaatc taagtctttc agacaaatag

56221
ataatcttca aaattccctg attaagttga catttatttc aaaactctcc tttacagttt

56281
gccaagagaa gtaggcatac tgctttctgg gaactggtgc tgcaatcagg cagaaaggct

56341
ttttctatag tgaacttctg atgtgttact gatcagaaaa ttacaaaggc tagtggcagt

56401
gatgacatca tgctgtactg atcacaattc agattcattg aagagcaagt ctaggagaat

56461
cagaggtaca gagcctgtag taagaattct ggaaattaca tccttcacta cacatttctg

56521
catttttaat aaagggacaa agacaatatc cttttgagat attcccaggc acacaggagt

56581
gctaccagta ctaccacttc agacagctaa aactatgcag ggttggaagg gagagatttc

56641
tcctttcaat tgcttcaagg tgtagtagag atagttggac aagtatagtt tttgtttgtg

56701
tgtttgtttg agacagagtc tcactctgtc gcccaggctg gagtgcagtg gtgcgatcgt

56761
ggctcactgc aacctccgcc tcctagttca agcgattctc ctgcctcagc ctcccgagta

56821
actgggatta caggcatgtg ccaccacacc cagctaattt tagtagagac ggggtttcac

56881
catgttgacc aggctggtct tgaactcctg acctcaagtg atccacctgc ctcggcctcc

56941
caaagtgctg ggattacagg tgtgagtcac cgcaccggac caggacaagt atagtttttt

57001
aaagcctcaa tcatttcttt caaatctgtt tgtgttaaga aataaagtga ctttcaaatt

57061
caagggccat aagtgcccca gggatgcctc aggtcctttt ccacctgggt gagtccatgg

57121
gaccagcctc tgaaagccac tatttcttgc taccttgcac tccccccggg actcaggcag

57181
cagggccaga tcccatccca gcaggccggg cagccggctt ctccaggcag ggcctgcttc

57241
taacctacca tctcagagca cttcccctct ggggaagtgg ggaaggggca ggggagaggg

57301
aagtctgtgg ctggagcagg ctgcaatggc aaaggctaac tatgtaggtc acacatgcgg

57361
aagggccaag gactccaaga ataacacagc ctaggaatgg ccaagaagta atggtgcaaa

57421
gtcaaacgct gagccctgca ggagactcct gggtaattca ggagagacat agttgagcag

57481
cacggctggg caaaaaggaa tcccaagcac tgagacagga agtgacccac gaggaggccc

57541
acaaaaacta cacttctgaa gctgggccta tggcaggggt caggacagcc agcacccctg

57601
tccttggggc cagcaggtgg ggcaaaatcc cacaggatgc ttcagggcaa gccagccagg

57661
gtggtccttt ccccaccatc acacgattat ttctggtggg ttcattgatc tgttcaatgt

57721
tatgtcacca gcaatttaac atgcacagca gtcccttccc aaatgtttgg gtgctcaggt

57781
tctttttgaa tgagcccctt ctttgtaaac atgggtatga tctgtgagat tccacagatg

57841
acagcatcct gatctgtaaa ctatgctggc acacagacca tacctgtacc tatgggtgcc

57901
agccctgggg ccttttagct aaaatcccaa atggtcagga atggatggga ttcttgccca

57961
cagaaaagtg cagtcctacg gcatcgaggc aaaggacctg agatgcagta aaaatattgc

58021
tggcctagaa cacaggagct ttctgcttca atcccagttc tgccactcac cgtgtgacct

58081
cgcgattatt gtcccctctc tgagcctcag tctttttatt ggttgaatga ggagaagtat

58141
gtggccctca gaggattgcc aggaagatga aatgagcaga catctgcaga cattgcagac

58201
atctagaaag gcctttggcc ctatgtagtc tctttttggc ctgtatgtgt gtgtgtgtgt

58261
gtctgtgtgt gtgtgtgtgt gtgtgtaact cacctccccc atcagaaggg aggaagcttt

58321
tgaaaataat tccaaaggca tcagctttga ttttagagcc tctttctttc cctttcttct

58381
cattgtcgta tttcagatgg tatgctactg aagagtgcag acacatcagc cttcttccat

58441
tcctttttag gaattcaaag aacatgctaa tgttccctaa attgtgagct gctgccacgt

58501
gaaaagggtg attctcaatt gctccctcac tgggatatga acgtgctttg tcctgcatat

58561
gaacagtaaa gaaaggtcct ggggttggga tagggccagg tttggggaat aagattggcc

58621
ccacaatcct gaggagaggg gcttgaggtt tctaggtcat ctgcctgagg acagaaaggt

58681
tttccccaac ctcctattgc ccagcataaa gaacaaggat ctggggtctt agaaaccata

58741
gtcaagcctc cacagggaga tgtgtgaccc aaaaagggtg gactctgctg taagcgagct

58801
ccaggttgga gcctacacct ggctccacct ggacctacag gatgatgggg ccatacccag

58861
gaggagggag aacgggaagt ggagagagtc aggtatccac tcatgcaata tggatggggt

58921
aatggaacac tgcactttac cctctgctga tcctgctcct ggggcttcct ggtgccagga

58981
accacaggct cggctgcagg gacatcactg aaggacagtg aggacccctg ccccttttcc

59041
tcagccccgc tgactgcaag gcccttcacc tgggggcaca aggtcgcagc aagccagagg

59101
aagaggtagg aactatggag cctgccataa gttcctgggg ttgggggaaa ggggaatttg

59161
gcagtgagag gggacaggta gaaggggcaa aatccaggac cgaagataga tgggaaaggg

59221
cctatctccc cctttttcat ggggaccaag gagcatccca gaacacggag aggttggaga

59281
aagacaagtc aggctttgag caccagggcc atctgagaac tgaacagctc gtttcaacca

59341
catctcccat ctcctcatcg gcctctgccc ctgagtcctc tctggtccct gccccgccgt

59401
tctgatgctc tgtctccagt cctcgggctt tctctccaac cagctgagcc ggggaggatg

59461
agcgtgggga cactggcagg gctcggagct ctgaggagac tagactgagg ggctgggatc

59521
agactgaaaa gtccaagacc cagaggagct ccagttaaaa cggctctttc cggctcaaga

59581
ccacgttccc tgcttgctgg ggaccccatc cctctcctcc gtgtgtgaaa ggatggcaaa

59641
ggcggaagtg gaggggtctc tcactgccct gattccccct cctggctccc aatttgggaa

59701
gacagatccc gatctgtctc gggaccagta ggtgaggggc cgggtccatc tcccttctct

59761
gatgtgttct ctcatgtttg gctcttctgt gtttgtgtgt tttcctccat gcgtccctct

59821
ccctgcacct cattctggtg gcccccctca cagagccggg aggagcgtgt tctccgccat

59881
gaagctcggc aaaaaccggt ctcacaagga ggagccccaa agaccaggta ggacaggtgc

59941
cgcgtgagcc ccgcagcccc gcgcctcgcg gcgccctccc gccgctttcc agcccctgcc

60001
cggctgccaa aaggccctcc tgggataggt cgtcccaggg ccaggcccca cccagtgatg

60061
cgtggccctc taggaaggag acgccctagg gccgagggag ggaaacgggc agcgccctct

60121
gtcgggggtg cctggttaca aggctcctcc cgccctcgtt gctcccggtt cttccttctt

60181
cacgcagaag cccagtgttt taattagagc agagaatatc catcaagaaa cgctgtttgg

60241
ccaactccct atttctgggg ggaaaccgtt gtcccactag tacggggtcg gcggcaggcc

60301
tcgcccaagc gctctcacca ggctgcagcc tggcctttgg ggaggtcctg gggccgctgg

60361
agggcgcggc agggccgggc ctgggaggct ggagcagcag gtggcactgg gccctcccgg

60421
aggagcgact ggagagggga agacagctgc tgcagaggag gcgggaggcc tggaggaaga

60481
caaggggaga aatggagagg acaggggagc tgggaggggg ccatcttctc catcacgggc

60541
ccaccatcgg ggctcccggc tgccctcccc cagcatcccc tctgtggcct actggccctc

60601
aggctctctc ccccaccctc ttgcccccat gccaattcca gccgtgccct tcaccttctt

60661
aaatggagag agtacagctg ctggctgagg accaaaccca gcatccttgg gtggctgttc

60721
ggaatccaca tgtctgcatc tcattagatg aatacacacc aatgcattag gttctgaatt

60781
ccatcagctg tttgatatgg ataagttact tcctaagcct tcgtttctgt acctgtgaca

60841
tgagaataac gcccatcttg gcagggcaca gctctaagga ctagagatag tcatgtaaag

60901
tcctggtgtt gtgcctggaa cagagagtat ccacccaaca aatggtagct atttattgag

60961
aggtgcaaaa gtatggattc tttattccct accttcttcc ataagagata ttcagtgcct

61021
aagtaagtgg tatacaataa aagagcattc aattaaaata aaaaggcaag accagacata

61081
atggccattc aaatccaaga tcgggattag gtagaaaaac actgcagtta ttcaggccat

61141
aatattctaa gcggtagcaa ctaagtaaac ctcgaattta actctcagct ttctggatgc

61201
cagagtaaaa ggagaaatgg tcactatctc accatcagtc agcccaccta accagtcttt

61261
catcttcccc agatgaaccg gcggtgctgg agatggaaga ccttgaccat ctggccattc

61321
ggctaggaga tggactggat cccgactcgg tgtctctagc ctcagtcaca gctctcacca

61381
ctaatgtctc caacaagcgg tgagtggacg ggagccctgc aaccccagct gcccccaccc

61441
tgtcaggcag gacctggctt gccatgattg gaatttgggt agggaagaat cagggctcat

61501
ggacggcttc ttcctaacct aaccttaccc ttttctgctt ttccttgggt gtttttctca

61561
cctctctccc tgcaaaagca gagcacagca gctgcaggcc tgttctcagg tccttgaata

61621
cctcccagcc caaggaagcc acagacctgc ccaccccata tttgaaccta ttgaccccat

61681
gtctgtctct ctgttacttc tgcctttgat tagttctctg tgttgaggcc tctgaagaca

61741
actaatcctc actattcttg gcagtgcttg agtgtttaaa gaccatgatt ctgtccctct

61801
gcccactccc aggtctaacc actgccagtg tcctcctccc caacaagcag tccccatacc

61861
ccaggcctga tggtacattc tcttcctcag atctaagcca gacattaaga tggagccaag

61921
tgctgggcgg cccatggatt accaggtagg tgggcacctg gaggcctcat gtctttcaga

61981
ctctgctcta gtgggggatt ctagccggat gtgcattatc cactatactg aggcatggat

62041
ccaggggtca tagagaacaa caagctgaat ataagttccc aaagtaagct tgttcctggg

62101
aggcattcct agaagtatca tcagtagaga gatacaaacc caaagaaaag cttgagaact

62161
ctgcctatgc taatcaaagc ccttccagta tttcatgttc agtattggac ttcataaagt

62221
gagaagcacc tagaaaaacc ataaagagac caagaactac aaaaaagtat tcaaacagtt

62281
aaaataaggg cctttgaaga aagttttcct ggcatgattt ttaaattgtt gttttgtatt

62341
atttgattgc tggaagtaat gacgattctg tttatctctg gatggtgaga ctgtgagtga

62401
tttttttctt ctttttgctt ctctgtattt tctgagatta acacaacttt tttatttgtg

62461
tgcttctaag accagagaca aaagactgag acaaagagag gttgacagct gtaagaatgt

62521
gaatgtggcc aacagtgcag gcaggacagg tgatgagcat gtctggtggc tgctgggaca

62581
ccatctctca ggaagggccc agggaccctc cattgctcca gaccctccct tggaggctaa

62641
caggactcag ctataaatca gaagactgct gggctttcct aggattgagt tagaatgctg

62701
gctgctcaga ggggacaggg cttgcaagag atctcacctg gctgccactg cacttctgtc

62761
ctggggatgt tcggtctggg tatcagcacc aggccccaga atcagagtga gccccatcta

62821
ccagggtaga gctttatctc tgatgcctag ttccagaccc caagcacact aacccttctt

62881
tacggacaac cccacctccc ctcactcagg tgatgatgga aaggataaga tggcactttt

62941
ctatgtaaaa ggtacatctg gccatgtttt ctccagaata tacttcatct cccttcatct

63001
ttgttttagt tagtttccat ctactcaggc aactgtcttc ccaggtgcct gaaaaacagc

63061
cccaggcaat gtcaaacgga cctgcccctg tggttttaaa taacttcaag ccattggatt

63121
ccttaggggt ttgagaatgc cggcccctca cctctgccaa aacccaaaca caaagtgtcc

63181
tgagacttcc gagggctttt ccaagggatt gggctcaggg ctttgtttct ctgtgtgctg

63241
agaactggag aattccaaag aacaacgacc ccaactcagg tatcatgtca ctggcctaag

63301
aggtaaggac acatcaaaaa tagagtcatt attgttcatg aaacttattt ttgaaggttt

63361
attctatgcc aggcactgtg ctaggagcta tatatgtatt tccattgaag ttaatgtaat

63421
tcttcaacca cccaaatata ggtgttactg catttatagg taagaaagtg aggccccagg

63481
aaggtcagga acttgtccca ggtcgttgcc actaagttag ccaaggttag agccagggtt

63541
caaggccagg ggtgtctggc catagccata agagcaattg acttctctat atcaagcctt

63601
ctagacagct gctcccttcg ggtccctggt tcatcttcat cttgctactt agtgcttgtt

63661
ttccaaacct tttcaaactg cctcctacca gagactttta ttaactggac cagacattgt

63721
cccctccaaa gactttttaa accgaactga acaaaacggt tgttgtattt aacctggtag

63781
catagtgttt cccgacaagt tcattcacaa ttaaccttgc aaacatttga gtgagagcta

63841
tgaggatgca aatgtgaaat tattttcact tccaatacat acagtgtata atgcaataaa

63901
agcaggccgg gtgcagtgac tcatgcctgt aatcccagca ctttcagagg ccgagatgag

63961
tggattgcaa gaccagcctg gccaacatgg tgaaaccccg tctctactaa aaatacaaaa

64021
attagccagg catggtggtg gcgcatacct gtaatcccag ctacttggga ggctgaggca

64081
ggagaatcac ttgaacccag aaagtggagg ttgtagtgag tcgagaccgc accactgcac

64141
tccaacctgg gcaacagagg gagaccttgt ctcaaaagaa aattaaaaat aaataaataa

64201
ataataaaaa gcaataaaac cagatacgac ttcactctct tggagacttt gggtttgatg

64261
agatataaag accgcaggaa ggacacctcg ttggtgagat gtggggagac ttagctgaac

64321
tcagatccag gaagggttgt gagggctcag gaccattcta aaggttatgg cactgaaaga

64381
agcctggagg taaaaggacc gcggcgtacc catgctcttt gtttcttcca tttagaatgc

64441
acgtcacgtg taaactcttt cctgattatt gccatctcca aggcaagaaa ccacagtcac

64501
ccccctgtga atgtgcagtt tccccaccag agtgagcaac gcttggcact tggcagagat

64561
gttcttggtg gatcaagggg tcttgagtct ctttattacc atctcttcct ggcaccaaga

64621
cttaatacat tgtcacccaa catctctcca gttttcacct ccatttcatg cccctgccac

64681
tgacctgagg tccccagcct caactgcatg gttgtaccta ctttctacct ggtctccctg

64741
ccctcatatt gcctcctcca ctccaaactc catgccacca ctggagcaaa cttctgaaaa

64801
tgcaaatctg gtcatgtcac atctctgcca cctggaaaag tggggagtgg gtaatggatg

64861
ttgcagaagg acagtactaa agggcgcacc aactctcatc tctggctccc agcagatgtt

64921
cctgaagctg gatcaggtcc ctgggaagca ggtcacaaag cattattact ctcgggtttt

64981
cccaggacag gggtatagat ttaccactca gcattattcc ttgtgatcgc tttcatgaag

65041
ccactgggga gtatgtccct tatcttgaaa ggagatggtg gaatagtcag ctggtcagtt

65101
ggtcccagct gtggctccgt ttgcctcttc atcttccacc ctggaaaaat tgagtcctct

65161
gctgatgatt ggagagaagg atggccaagc ccctccccca gaaccctgga gaatgaccag

65221
ccatttttta ttttttattt caagtgcatc atttcccctt cctagagccc caggaggggt

65281
gggaggcagc aggaatggca ttccccttcc cccaacacca tgcgcctggt ggtctttctc

65341
cagcgccctc agcttcctct cggggctgcc cttcaaccag caatgagcac cctctggagc

65401
ttctcttccc tccgttgctc cttcaagcct ctgcccacct tcccctccac cctccgcctc

65461
tactgccaga gcttctgccc aggttgtcac cttcactggc tctgctacat ggaggaaggg

65521
agaaacgtat gaggcctgaa aagggggaca gggagaagta gcctgtctta tggccatgcc

65581
tcgagatgga aaacataaaa accaaccact ctcttggcag tgggaagagg acttgctgct

65641
ggcttatctt cggtagatgc caaaactatg tctgtccgct tcccagtcct gagttataga

65701
aagccttttt tattgttggt gggggcatta gttgtggaaa aattcatggg gtttttaaaa

65761
atctttggca aaaaagggtt cgtggaagtt aaaactctac aaactattgt gcaaagaagg

65821
acttctagtg tccgtttgct ctcttcatag taaacttctc agagctaagt tagttagtcc

65881
tatttccttt ttagctccct gaaggagcag tgaatattga acttctgtga agctccagat

65941
tctaagcttt tacttccgtc cctttgtcac ttcacgttcc aaacggaaat gtttgcttcc

66001
tagttcaagt gtcacttcat ttgtaaatat cccctttcct ggcaatgttc tcattaacat

66061
tggaatttct atttccttaa catgattact tctgatgtgt agatttttaa tcaccctcag

66121
gttatttttc agactttgat ggacactgga tgatcatttt agtggttatt ctttttcatg

66181
gaaagggaag ataattctct caagtaaagt cgtatttaga agttgcatca aagcacaact

66241
aaaatatgaa atctccaaga tgacaggcat gaaaagcaac cttcggagtc gcattagaag

66301
aatgtgccgg gctcagtggc tcacgcctgt aattccagca ctttgggaag ccaaggcagg

66361
tggatcacga gggagactga gaccatcccg gccaacatgg tgaaacctcg tctctactaa

66421
aaatacaaaa attagccgtg cggtggcagg cgcctataat cccagctact cgggaggctg

66481
agtctggaga atagcttgaa cccgggaggt ggaggttgca gtgagcctag atcgtgccac

66541
tgcactccag ccggggcaac agagtgagac tctgtctcaa aaaaaaaaaa aaaaaaaaaa

66601
aaaaaaaaag aagaatgtac agaggtccat gcttattcta gctggggaaa ggcttttctt

66661
gttaaaacac acgtttgaga gaggcaagtg aatcaatcat tctaagtatc atgcacaagc

66721
tccctacttg agagatcaac cgcttagctg aagggagatt ctgttggggt cactcacatt

66781
ttgtagagct ttctgctgtt taggatgcat tttgacacac atgatctcat ttaacctgca

66841
tacaacctta caggtagctg gtgtctctgc ttgtaactga aaaacacaag gctatgtggt

66901
catttgccct cacacctggc aacatgtcag gtctggggtt caatcccaag ttcagcaacc

66961
cccagtacat gcctctgtct atcttaacat ggccaccctg acaggaactg acacctccaa

67021
atccaaatga gacctgatgg cttaaaatga gggttcggga aaagtagtag tgatgtcaaa

67081
aattactggt gctctggctc tctctctctc tgtctctctc tctgtcctta tatcttttta

67141
gcttaaaaag ccaataattg gctggtcaca gtggctcgtg cctgcattcc cagcactttg

67201
ggaggccaag gcaggcagat cacctgaggt caggagttca agaccagcct ggccaacatg

67261
gtaaaaccca atctctacta aaaaaaaaat acaaaaatta gccgggcggg gtggcatatg

67321
cttgtaatcc cagctacttg ggaggctggg gcagaagaat cgcttgaacc caggaggtgg

67381
aggctgcagt gagctgagat catgccactg cactccaggc ctgagtgaca gagagagact

67441
cagtgtgaaa aaaaaaaaaa agccattaat catttgtggt aagctccaca aggaagaatt

67501
tgttgcaatc ccacctgtgc ctggctccag caggtttcca ggaaacattt gttgcatgaa

67561
tgaacaactg aaatagggct tcccaggata taagtaagat tgcagagctg gacgccacat

67621
aaaggacaca gcagagtgca cacaacatac aatcagtagg ctgaaaaagg cggctcaggc

67681
aggcaccaaa gccgcactgg ccatacaaac aaagaaattc agcaaacaat gtggaaaggg

67741
gggggagcca aattccagaa atgcaaagac gtatcagagg cctgcaggct tacatgagaa

67801
ttcctggagc aggaaattaa atgcaagtta atgaagactt tgaaagcttt attcctgagt

67861
gcatgaaacc tgtgacatgg gtttggcagc tctttctgaa gcagagccat cgacgctggg

67921
gaagaacgca gggcacttgg catcacctag gagctttaaa aatacagatt ccagcctggg

67981
cacggtggct catgcctgta attccagcac tttgggaggc cgaggcagac agatcacttg

68041
aggccgggag tttgagaaca gcctggccaa catggcaaaa ccccatctgt ataaaaaaga

68101
caaaaattag cccggtgtgg tagtgcatgc ctgtaatccc agctactcag gaggctgagg

68161
cagaagaatc acttgaaccc aggaggcaga gggttgcagt gagccgagat catgccactg

68221
cactccagcc tgggcaacag agtaagactc catcaaaaaa ataaaaatac agatgcctga

68281
gctgcatgtc caggattgga ttggattggt ctggaggtgg cctgggcatc agtgttttta

68341
atgcctctcc ctcccttcgg cccagcaagt taagtctagt gaacactgac ttagaggtta

68401
gccaactcat actcctctat aaatgaagac acttgaggca tagaaggaga aagagccagg

68461
atcacccagc agatgagagg cagtggtcag aatggagccc aggaggccag tgctggctcc

68521
cgggccctcc ctctgaccct gctgccccag cccctggacc cctgcgggac caggctccta

68581
ggctcaggca gctttccttc tggctccccc ttctcctgcc tgcaggtcag catcacggtg

68641
atcgaggccc ggcagctggt gggcttgaac atggaccctg tggtgtgcgt ggaggtgggt

68701
gacgacaaga agtacacatc catgaaggag tccactaact gcccctatta caacgaggtc

68761
agtggccctg tggggaaagg agcctctgta aatatggcag gagggtggcc ccagccctcc

68821
ccaggagaaa taggagtggc tggaagtcaa ggagcacaca gggctaccag caggggtgat

68881
ccaccctgtt acaaccccca ggacactgac aaacagagcc acatcttctg aatcctctga

68941
accccccagt ctagagcaca ggccgacact ggtctttgaa gcgtacacca cccgggtgct

69001
cctgggcaga ccccagcagt gcctgtgaaa gaaccccccc ccaccccact ccccaagagg

69061
cctggttccc actgtttccc aggccagagc ccaaggacag ggctgcctca ttccaaccca

69121
tggtggcact ggcaccatta gtaagcactt tctaccagcc aggcatgctc ctaaatgctt

69181
ctgaactgga ccatccaaag ttgtcactat caattccctt ttacacaagg ggacagtgag

69241
acttctgaag gcagaccttg tccaacctca cagtgccagc atcgcccttg gcgtgctagt

69301
ggggttctgc cctcttggct cggctccttc atggttgcct aaacttctgc gggcttctct

69361
ccagagcact ggccttgatt ttagggtgtg aaagagaaaa catttggtac ccactcctat

69421
tctttccagc catttgaggc cacatcaagg gtgagggacc tcagagacct tctactttaa

69481
tctccccatc ttacagagga ggatactgag gcctccatat ggaagggcct tgcccacaat

69541
ctcagagagt gttgctgata gagcaggggc caggctgccc acccagcttc cagcccaggg

69601
ctctggccac catcacaaat atggcacctt ggttcccagg ctccagatgg gaccccatca

69661
taatcagctc tggggaggga tgtgagaaat agagaaatac actcactcat caaaacccaa

69721
agaatgactt agaggcatga agaacagcga aagtgagact tttaataacg gtcttgcaag

69781
atggagtgtc tggtaggcag gcacccctgg ggcagtcaca acaggaattt atctcctagt

69841
gtgcaagtcc ctcccccact tccccattgg ttgagcacta tggggttaca atcttccctg

69901
acgtcgccta agtttcattt tcccccttac aaggttatac cccgctcccc ttcgatttcc

69961
ccacttaagt ttcgatttcc caataacaaa actttcttcc ctttcatggg ctgacccctc

70021
ctctacattc tgttcgctta ttgtgtcctt ctaggtgcat gagccgtgtg gtttgttgca

70081
ttcgcaggtt ggatgccagt acttagactt atcctgcctt gaaaatggac cattgaaaat

70141
gttttctcac caggatgccc aggcctttcc cagatgcctg atcacacatc agactaaccc

70201
agaagccaca ggcctgggcc ctgccatccc tttcctggag ggttccccag tctgtttctc

70261
ctggtggctc caggcagtga ggggtgccag gctgtcccaa gtaaggcagc tgagtcccgt

70321
accctgaggt gggtgagggc tgaggtgccc cctgtagctt gggggagggc atttctcagg

70381
cagctctgag agtcctcaga ctgtgcacct gcaggaagaa aacccaggcc cacctctgcc

70441
cttcagccca ggcctggccg aactctcctt tgtgaccaca aattgactct gctctcccag

70501
ctgctttccc acaggccccc cgagctggac aacctgctca ggacccctcc agccccaagg

70561
acattcagga ttgacatctc tggccttacg ttaggacaca tcctgactgg acaagtctcc

70621
gcctagataa gcatctatgt ccccaagaca ggcatggaga caggtccctg tggccccggt

70681
ggttacttga tagcagtgaa gccacttctg ctaacttaag ggatctccct ccaccaggcc

70741
cacacacctt ggctttcatt caaattactt cctctttccc aagggcacag agctgctctc

70801
cctactctgt ggctccccca gaaaactcct actcacccgg cagggcccag ctcaaatgtt

70861
cttgctactg agcagccttg cctgctctgt ctgggtcaga ggtcagcact cccctttctc

70921
tgcagtgtta atgtcctgga gttgaggttg gtcctccgtg tctctgtcct gctggtggac

70981
tggaggctcc cagtctcctg cctcgctatt tgttcagagc caggcatgta ctcggagggg

71041
ttcagtaaca ctcacccaaa ggaagacaca aacatccact gagcatctgc cgcacaccag

71101
acagtggcac gtggggcaac atggaggctg ccgagatgaa ggaggcacag tttccgccct

71161
gcgcaggtcc cctccttgtt tcagcctaga atctttctaa attccctatt tacttcctct

71221
aagactgact attcattctg ctcatctttg gacaatctta aatgtgtttc tgatcacatt

71281
tttgttcttt ttcacaaacc caaatagctc tgattttgtt tctgtttcct ctaaactagg

71341
gtttctcaaa ctcagcacta tggtatcttg gactggataa ttgtggtggg atcgtcctgt

71401
gctgtgtagg atgtgagcag catccctggc ctctacccag tagatgccaa tagcaactcc

71461
ccttagttac agctaccaag tttccagaca tgccaaatgt cccctgaaat cgccctcagt

71521
tgagaccacc attctaaact atcttactat gattccttcc agccccaaat cagcctttcc

71581
agccccaaag ctttgtttcc cttttcttct ctttctatgc cacattcctt ttcaatgaag

71641
gacatcctcc tcgtcgtggg aatgtattat ttctgactaa ttatctgagc tggtaggaac

71701
cttcctttgg ctccattaaa acaacagagg gaggtgggaa caatcaacat gacttaggta

71761
tctaagctat tacaaaagga aaatatgctc aggaaataac aggaatttga ttgcagacag

71821
ctcagagagt tcgggattct ggctctagct cagctagctc gctcccctgg ggctggcaca

71881
tctgcgggca cctggcctga tcaccctgcc tggccctgag cctgcctgtg tgcagggaag

71941
ctcaaaacct ttgcccttcc ggaacaagct ggccattcac aaaccagact aaggctcctt

72001
tcctgtgtgt cctgtgtgtg catctggccc cgccctgggc atcttgggag cgccaccatc

72061
cttcctcctg ctgaaaatcc acctctcccc tttgccttgg atccttctct ttctacagct

72121
caaagaacct ggcattgcac agcccaactc tgtctttgtt tttcttccag ccccttcttc

72181
cttgcctata aggtgttcta ctccagcata tgctaagtac aaccatgaag acccatgtgt

72241
gctcaaggac aggaactagg agtctgtcac ctctctctgg gcctttcctc attcccacac

72301
acttctccag tgacctcctt tttccctcca cccctccaca gtcagaccac ttgggttgtc

72361
ctcacttcct ccccccagtc acccctcaat ctctgcaggg tttctgcctc cagatgtcat

72421
tgacactgct ctcctcaagg tcaccaagga cattgctgtt cctgagtata atgtccatgt

72481
catcctcctc tcccttgatc acccagtttc tttcatcccg ctgcctgctg ctcctcttgg

72541
gggcccctca cgccactctc ctgcttcccc tgtctctcca gctccatctc cccggcctaa

72601
cttcttggct gaaaggctgt gtcttcttgg agccctgacc tgggcctgct tcccctccca

72661
tgctctcccc aggtatctcc tccatctcca aggtgtcagt taccatcttg tgctgacgat

72721
tcccaaatcc atatccccac ccgcctcccc agagcttcag aactctggcc agcacaccct

72781
gggcctgtta gtgtcatgca cagctgtcgc tgcttgctat gtgcttaccg tggtgcacac

72841
ctgtgttaaa gacttgacca gggtgtctca ttgcaacttc acaaccacac cttgaagccc

72901
cccaagtgaa tggcacccct ggagcagttc agcacgacag ccctggatca tatctccaca

72961
ttcataggat aataggtaaa ctgaggctca ggcaagaaag tgagtgatct agcagtaaca

73021
gccaggtggg gctggctctg aagctggctt taccctcagt gctcaagggc cagcccccag

73081
cagccaggag cacgttctct tcggacattt accccaagca cattggaaat atttctccct

73141
tctcccccac cacagttcac caaagcagca gcccctctac tcactgcccc acaccctcat

73201
cctcagcacc tgcacaccca ggccagggga agagatgggg actgcaaatg tgcatggcag

73261
cccacagcac caaaggacag tgcacaccca tggcatttca catcgactgc caactaagtg

73321
cttggcacac catggttcat ctgctctgag gcttgcgtta ttttacagtt tcacctctct

73381
gaatttggga tgtgtctcct aggcagcctt gtggcttcat ggcaatgtcc atgtggctta

73441
ttaaaccgta gtatatctta cagccagtag ccactttaga tttggtaaaa tatgttacac

73501
tgtctcatca gagcctcata acaagactct gaggtgggtg tcattatccc catttcacag

73561
ctcaaaaaac tgaggttcag agaatgtgtt gctcaaggcc acacagttaa gaaggtgcag

73621
agcggggact agaacccagg tctgcttgct ccctggccct gtgcctcttc tgagcacagt

73681
acaagggcat gggctgtccc acctactgtt ccaagttcct ttcccacccc acactagcca

73741
gcaccagccc cacctagggg atggggctct gcttcctacc acccaccacc agggtcaatc

73801
aggatcagat gagttgcctc tgctgctcct ctgaactttg gggctcaggg caaatgtctg

73861
gggtgcagac aggccctgcg aggagggagg ggcccaacac tgcctgggct gttgctgctg

73921
ccctcagtga cagcaggcct ggatccttcc ccctccagta cttcgtcttc gacttccatg

73981
tctctccgga tgtcatgttt gacaagatca tcaagatttc ggtgagtggg gagcagcccc

74041
tggccggcag ggccactccc tcaaactgca cctttgtgca gacttgagag gggccccctc

74101
tgtctagacc catgataaag aggcagcgcc gtgcctggac acacggctgg gcaagtaggg

74161
acaggctgga ttctggcccc cacccacccc tttcattgga tgcctctgaa tagtgcattc

74221
gcccgtaaac agtggccagc aagaaactgg cgtgggcagg aggagctgat gctgagcctc

74281
agtgagccac cccactctgc caacgccctc ccacttcacc acaaagctcg ggtcccacca

74341
ctgccccatg gaaagcctca cccttgctgg gcctgacggg tgggctgtgg ttctgcctga

74401
aaggtgattc actccaagaa cctgctgcgc agtggcaccc tggtgggctc cttcaaaatg

74461
gacgtgggaa ccgtgtactc gcagccaggt gagtacctgc gcatggccag tcagtcgagg

74521
tgtgcatggc tcagggagcg tggtgcacgg ggcccttccc actgtggcag ttcctgggaa

74581
aaggctggca aggaccacag tctggcgact gttagtacac acagccatct ggcctgcgga

74641
gaagtggcgc gcacagtctg tacacaaatg cagtgagcaa ctgcgcaccc agtctggtgg

74701
gttctcactc ataattaggt gagtaactct gcacagagcc tggaaggagc ttcatcacac

74761
gctctggagt gcatggcagg ctggtgcatc actggccata ggcaggctga ccagtagtgg

74821
tagaggatgc ggtgagggag acccgtcaca gcctgcagag aggctgcgcc cagactcctg

74881
cctcctgggc tggcacctgc tgagcagaaa agaacccctt tccacccctc acaggaccct

74941
gccgtcccct tttacagttg aggctcagag ccagggcttg ccccagccac acagctggcc

75001
gggggtgaag tcaggctgtg tgtccccaga gcctcactga gccacactat ccaatctgaa

75061
aggggtgatg ctggtcaatg ccagatgtag tgcggcggcc tctgagggac tctggtctct

75121
gaaaacactt cttacaagag ccccaggctt ttgggcagcc atgtgtgctc cgtggcgtcc

75181
tgtagggtaa cagcaatggt gttggcaagg gaaccccaag gggtggccca gagggcttgt

75241
gaggtgggcc aggcagagga agtgcctcag cctgccagat gacagctcac cacgtgggca

75301
ggttagggac caccctgtgt ccctgaagtg aatgcactgc tcagagtgct gtaatgaccc

75361
cattaggcgc tttgacagtg agaacataat ttcacccaat tgtcacattg ggccctcaca

75421
aaacagtaat gtaggcagca gcatttcttc ccattttgca catgagataa atgaggctaa

75481
gagaaatgaa ggggcttaga gataccacta aactagtagg ttgaacaaat tggcgatcgc

75541
ttgtggttca acctaagaga cgtccagctg gtgcacatta caactatgac ttagaccagg

75601
gaatctgagt ccaaaaccaa gattatacac ataaaaatca caagatcata gaacactcaa

75661
gctgcccaag acctgaaaaa catctagtcc agcctctgtg aagataaact gaagcccaag

75721
gtgatgaagg ggtttgtcca ccatctagga gtagcacccc tgtctccagc tcccaggcca

75781
gtgcctttgc caccacccca cacatgccat agccctcagc ggagggcagc cctgctgacc

75841
atcagtgcca tggggagcag ggaagagtcg gcctcctgcc atgttgcttt ccaggaagca

75901
tgcatagccg tggactactt gcttggaatg actggcatcc ctgaggataa gctcctccca

75961
gggctgagca gtggccctgg taccactggc aggcctgagg ccgagagcca agagaaagtc

76021
agggggtgga gaaaaaggca gatattagtc taatatggac ctctgggctt ctgggtagta

76081
aagtcctggt gaggaaacca ccagggcatc agtaagtgcc agatgttggg ctaagctcac

76141
tgtcccagca ggcctcaccc tcacgacccc atataggcat cattcccatt tcaccataag

76201
gaaactgagg ctcagcaggc ttaaacagct ggtccagggc cacattgtga gtaagcggca

76261
gaaacaggat gtgggccgag gtctccactt gggtaaccta gctcgagatt tgctgcttct

76321
gctgaatcca gccctgagcc tggtgccctc ccagggacag gagagcctga agtcacatgg

76381
gtcctggagt tgagacccaa tgtctttact ctgatatctc cagtttggcc tgaacttctt

76441
gatgagtcgt tggttccagc cagggcattg ttggacagca tgctcccaga gacactcctg

76501
ggtgctgctg ggaagctttg ggtggtgtcg atatctcttg gaactggaag gggtttcccg

76561
agagaacctc ttctcaccct ggcaggacca cattttgtca tttgtaccac cagatgcaac

76621
atcaggaaac tgtttactgt ttgctactct ctgttggggg tgaggacggg ccatacactc

76681
atcctcatag atcatagagg aagtcagggg catacactca tcctcataga tcataaagga

76741
ggtctgggat gcagcaactt ccccagctgg gctacccttg actggcaggt gtcagcccca

76801
ggctgaaggg aggtgaaatg atgtttcagg ctggtaagca tatagctcag gatctcatgt

76861
ggtccttgta tctctagcct gagatcacac agtattagga ctagaagggc ctcagaagtc

76921
atgagtcaag tgttaacctg atgtagggac ccccacagca ccatctctga ttggtcctct

76981
aaccttgctt agtcctccca gaaatggggc actcactact tcttatttta gatatcttca

77041
ctttctttag gtcatctcaa aatctgtcac cctgtaacct tcacccactt tcacacgtct

77101
ctctttcagg acaaaaagaa aaatagcctt taaatttgaa ggtaaatttt acattcctcc

77161
tgaaccgtat tctctttctt tgctaaatgt ccccaattca tctaaccatg cacacctcta

77221
tacatctacc cctgtatcca tccatccact cacccaccca tctacaaatc catccaccca

77281
cctgtccaca gatccaccca cccatccatg tatccatcca ttcacgcacc aatccatata

77341
tccattggtc cacccaccca cccatccgtg aatccatcca cccacccacc cgcctgtcta

77401
cagatccacc cactcaccca tatatccatc catccaccca cccacccatc catatatcta

77461
cccacccatc tatccacaga tccatccacc tacccaccca tccacagatc cacccaccca

77521
tatatccacc catccaccca cccatccata tatctaccca cccacctgtc cacagattaa

77581
tggctccttc tatccagtaa tccattcacc atctgtccgt ctatctctca gccggccagg

77641
cagctcacca cccatccctc tgcccattta tgcacccatt cattgagctt tctgtccatc

77701
tcctcatccg acacacatct gctctggcaa gacctgaagc tcctgggatt cctgggacat

77761
ggcccctccc tggaggcctg ccagcctggc tgaggttctc cagtgactcc tcatccacgt

77821
gccttcctgc cctctcacct tgcttgtccc tctcttcaga ctctactgtg gcattatctt

77881
ttctgagaca caggtggcct ggctattccc agaaaggcca acctctgtac acagccccta

77941
acatctccgg gagcccacca gggccacagg cttgcaggac acaggcctgg gctacggtag

78001
aaggtggaag aggagggagt gaaggaggga ggtgctgagt ccctgagagt tcagtgccca

78061
cctaacatcc cgggaagcag attcctaagg cacagtgatg cgcttccctt tgcttgccca

78121
ctgggcttaa agtaaacctg aaggggcaaa tccttcctaa agcgcctcct tccctgacat

78181
ccgtcctttc ctccacacag tcataggtca tgggacactg ggatgagact gacaatccct

78241
gtctttagga gactctcagt ctaaaatcag agccaaacaa tacccagatc agcacagtga

78301
gatgggaggt gtgcatggag agcacagaga acaaacacta aagagcccag gatcaactct

78361
tccgaggaag tcagggaggg ctgcatggag gaggagagac ttgagcaaaa tgagtagaag

78421
tttacaaatt gaatagggag aaagacaggt ggaggtggag agaacaggaa tgagggcatt

78481
ccaagctcaa agagcagcag atgcaaaggc atggaggtat aaaagggcat ataaaaccgc

78541
aacacctgtt cagcaaggag gaacacaggg ctgggtgggc tcagcagagt gagtcaggga

78601
gcactaaatc aggagcctgc aggccatgcc ttttgtcttc accccaaggc actgggaagc

78661
cccagagggg ctgaagatgg ggagcaggag catgagcctc cacctgggaa ggccctgtgt

78721
gcagctgtgt ccttcacagc tatgtgaagg ctggctgact ggggtggggc catagaagag

78781
gccacaggca gaaaaaccca attaggagga ggctgtcgtg cttccaagtc acaccactca

78841
tgggatatat gtccatgggc aggccatgca cccactgccc cagctccaga ggacctcaga

78901
ctctatcaca ccctgggcta gggacaggca gagctgtggc cccaggtccc gggactctag

78961
ggaccaagac agcatttggt tctgccaccc cttggcctgc cctgagcact gggagacgct

79021
ctgggtgggg gtgtctggtg cagtgcccac ccctcatcat tgcagagcac cagttccatc

79081
acaagtgggc catcctgtct gaccccgatg acatctcctc ggggctgaag ggctacgtga

79141
agtgtgacgt tgccgtggtg ggcaaagggg acaacatcaa gacgccccac aaggccaatg

79201
agaccgacga agatgacatt gaggggtgag gcccagctac cccagcccct ggagtctgag

79261
ccagcccttc cttcccccag ggagcccccg gtgagggttt gctgagagca cctgccaccc

79321
gtctccctca ccctgctctc gctcactctc ccaagcagcc ccactcttcc gaggcagggc

79381
aggggcaggg ggtgatggag gatggctgag aatatcagtc ctttgacatc ctttctgcca

79441
gtgagaaatg ggttgagaag agtcgatgct ggcagaccag aaccagcagc tgctgggtcc

79501
tgagtatagc agcaggaagt gctgggagag ccaaggtttc ttctggtgtg ccaattccag

79561
gcagctgata gcagctgttg agaaatattc tgtgaccttg tctggagtca gtgggtaaaa

79621
gtgctgggaa tcaatgaatc ctgtcttttg tgagctgggg gagagagagt ggctactgtg

79681
aagtttttgt ctacgaaaca aaagatacgg cacaaaacta taaaacactg acaataatac

79741
taagatcata tcccaatgta caatctacaa agcactcata tgttttagcg tgcttgagcc

79801
gatcatgttc ttgggaggtg ggtattatta cagccacctc aacagtgagg aaacggcagc

79861
tcagtgagat gggaagattt gcccagaatc ccacaagggg caagttccgt gaacacaagt

79921
gtctaatcct agccttgctc cctcagctgt cccttagaga ctgtgccagg acccaggagt

79981
gtgtagatgc caggatgggg gttggggacc tggacctggt gaccatggcc ctggctgtat

80041
gtgctggcag gaacttgctg ctccccgagg gggtgccccc cgaacgccag tgggcccggt

80101
tctatgtgaa aatttaccga gcagaggggc tgccccgtat gaacacaagc ctcatggcca

80161
atgtaaagaa ggctttcatc ggtgaaaaca aggacctcgt ggacccctac gtgcaagtct

80221
tctttgctgg ccagaaggta ctggggtatg aggtacagga ggctggggct gggtgacagg

80281
tatcacaagg gcaggctgat gggtgtgggg cctggggcag ctgggcaggt aagacaaggc

80341
tggaaatcat gttggccagg gacggactta gaggatcctc actgcctcct ggagtcctta

80401
gactgagagc tgcgcagggg gcatgagagg gaggagaggc tgggggtgtg ggaagagtgg

80461
agacaagtcc acacacaggc acgcacacac acatgcaccc actcatacac gcacgcatac

80521
caactcacac acgcacgcat accaactcac acatgcagac acgcacccac tcacccgtgc

80581
acacgtgcac ccacgaatac acacacacat gcacccattc acacacgcac acacacccac

80641
tcacacatgc acacatgcac ccactcacac acgcacacac acccattcac acatgcacac

80701
atgcacccac tcacacacgc acgcataccc actcacacgt gcacacatgc acccacgaat

80761
acatacatgc acccactcac acgcacacat gcacccatta acacacgcac acatgcaacc

80821
actcacacac gcacacatgc atccactcac gcacacatgc acccactcac gcacacatgc

80881
acccactcat acacacacat gcatccactc acacacgcac gcgcacccac tcacacatgc

80941
acccactcac acacgcacac atgcatccac tcacacacgc atgcacaccc actcacacat

81001
gcacacatgt gcccactcac gcacacatgc gcccactcac acacacacac atgcacccac

81061
tcacacacac atgccacgcc ctcacctgtg ctcccccttc caccagggca agacttcagt

81121
gcagaagagc agctatgagc ccctgtggaa tgagcaggtc gtctttacag acctcttccc

81181
cccactctgc aaacgcatga aggtgcagat ccgagactcg gacaaggtca acgacgtggc

81241
catcggcacc cacttcattg acctgcgcaa gatttctaat gacggagaca aaggtcagca

81301
gcgggagacc cggtgtgctg gggggcagag ggagtggcct gaagggaagg aatatgtgag

81361
atgccctctc ttcacaccac cgtcatcagc tctggtcctc agcctcacag gtgcttccag

81421
ggccttgcca gcagcccctg cctcaggggg agggtgagga tttgtggctc aggtcggctc

81481
agagctggcc tgagcccagc tgactggatt tgtcagctag tagttgtgtg acctgttttc

81541
ccatttgtaa agtgaaaata ataatgatta tatgatatga taattatagt atgatatgca

81601
cattatagca gtgtatatac tgcatttgta tataattaca gtgtgtgtgt atatatatat

81661
gatacctaat agtagtgcct atctgcagaa tcgcagggat tgactacctc ctaggatccc

81721
tgccctgtgc tgggttccaa ggacatagag tgagataaga atctattcct ggatcaaagt

81781
gctcactgtg tattgaggag atagatgtgc taccaaatgg tcaaaacata aggcagaaga

81841
cacaaaaggc cacatgttgt ctgatccatg tatgtgaaac atccggcaaa tccacagaga

81901
cagaaagtag attgccggtt tccaggtgct aaagggaggg gattgggact aactgctaaa

81961
taggtgcaga gtttcttttg agggggtgga actgctctgg aagtagatga tggtttatag

82021
cacagtgaat atacgaaaaa ccactgaaat gtacacttta aaagggtgaa ttttatgtca

82081
tgtgaagtat atctaaattt ttaaaatgct ataagtgtgt tttttaaaaa aaggcagaat

82141
aaaaaggaaa tgaaccaaaa aaactggatc atgagacccc tgtcagaggc ctgacaaatc

82201
ttagccataa gagaagggac ttgtgcctag gaattgggaa ggcttcgtga ggaagcagca

82261
tttcacaggc agagatggag agggatggcc ttcagcaagg aggggagggg tctgcactgg

82321
cagggtcacc gtggtgggac agagctgcaa aaatggcaca gggcccaagg tcatgctgcg

82381
gacttggaag gactggctct gtcctacaag tagactgttg acaattcctg ctctaagttc

82441
caggaagcag ggagctagac tttgccttcc cactgcttcc agctcaggcc cccgcaggga

82501
agaaatagac ccaagagagt gctccacccc agcgcagtgt aagaaggctg ccccacacct

82561
gaatggcaca catgaagttc tcagctcagc acccaggagc tggaggccag ggacccccaa

82621
aagaggcccc tcttccccag ggaaactgga tgtgacgctg ccccctcatt tttgttccca

82681
ctgccacagg cttcctgccc acactgggcc cagcctgggt gaacatgtac ggctccacac

82741
gtaactacac gctgctggat gagcatcagg acctgaacga gggcctgggg gagggtgtgt

82801
ccttccgggc ccggctcctg ctgggcctgg ctgtggagat cgtagacacc tccaaccctg

82861
agctcaccag ctccacagag gtgcaggtgg agcaggccac gcccatctcg gaggtgagac

82921
cccaggcact gtgctgtccc ccagggcctc cagctcagcc cccttctccc tgagtcacct

82981
gggtcccagg ctttgcctgt tgctgccctg tctacctgag gagtcatacc tcaggataag

83041
gcttctcccc aggaagcaga ggcccccact cagccccgca acaggactct gccctcgtcc

83101
actgcctgcc tgtgctctgt ctcacaacgg ccgccaggtc tcacgatggt gcctcccctc

83161
tgcccctctt cccagccacg gctgtccctg tggtgtctgc agccagccct gcttccatgg

83221
atatccaggc tggggggccg ttggggtgtg ggctgcctgg ccccaaagcc gggtgggatg

83281
cccccaccat ccacccccac ggcctgtctg tgagacggaa ggaggcctgg cccccgacct

83341
gccaccctta ctcaagctca ggaacgcttt gaactgcctc cccacagagc tgtgcaggta

83401
aaatggaaga attctttctc tttggagcct tcctggaggc ctcaatgatc gaccggagaa

83461
acggagacaa gcccatcacc tttgaggtca ccataggtga gtgctgggcc cacgggggct

83521
tcgggcctag gtgagtgctg ggcccacggg ggcttcaggc ctaggctgca ggtggtaagt

83581
gtgaggctct gcacctcagc cctgtcctca ctcttgtagg gaacgttgac ccctttcccc

83641
tgagaggcct caagcaccca caaaacacct ttgtgtgtgc atggggtgga ccacgcccca

83701
taaaggggcc aaccctcagc tccacctaca gggtgaggct gtgtttggga cctggggcag

83761
agggcaggga gaagcccttc ccggggctgg agaggagaga gtgggaactc aggccacagc

83821
ctgggccagg gctgggcctc gcactcaggc gtcatgagga ctccctgact ctcagcggag

83881
tggggacacg ggctaatgct ctctggctaa tgatgtgtca cgtctgagcc ccattccctg

83941
actctccctc tcccctttcc caaacccaag gcagcaccgg attggacggt gggaggggcc

84001
tggtggggaa tgcactctag gccttctggg cccattctgc tccaggcaac tatgggaacg

84061
aagttgatgg cctgtcccgg ccccagcggc ctcggccccg gaaggagccg ggggatgagg

84121
aagaagtaga cctgattcag aacgcaagtg atgacgaggc cggtgatgcc ggggacctgg

84181
cctcagtctc ctccactcca ccaatgcggc cccaggtcac cgacaggtgg gcccagcctc

84241
ccatcctcct gtggcctggc cctcccacct ccctgggccc ccaagacctc acctcccgcc

84301
tctgcccacc ccaggaacta cttccatctg ccctacctgg agcgaaagcc ctgcatctac

84361
atcaagagct ggtggccgga ccagcgccgc cgcctctaca atgccaacat catggaccac

84421
attgccgaca agctggtcag ggccaggcca ggggccagca ggggtggggt cctgggggag

84481
acggcgctgt cagagggcct tccctggaac acacaaagct ggtctgccca gggggctgca

84541
ggaacggccc cagcaggacc tctgttccca ttctcagccc caggtcccag ggcacagaca

84601
aggacaggag ccacctctag tcactcagcc tccagtgaat cctggggcag gagtgttggg

84661
ttccctgatt tttccagaaa tcttaaaagc aaggctaggg agacaggtgt ggtggctcac

84721
gcctgtaatc ccaacacttt gggaggccaa ggcaggtgga tcacctgagg tcaggagttc

84781
gagaccatcc tggccaacat agtgaaatgc cgtctctact aaaaatgcaa aaattagcgg

84841
ggcttggtgg cgggcacctg taatcccagc tattcgggag gctgaagcag gagaatcgct

84901
tgaacccgtg aggcggagtt tgcagtgagc caagatggcg ccactgcact ccagcctggg

84961
caaccgagca aaacttcatc tcaaaaaata aaataaaata aaataaaaca aaataaaaaa

85021
gcaaggctag ggaagggaaa tggggaaaag ggagaagcga gcagtgtctg aagctcagga

85081
gctgccccct cctcctctgc ccacccctct ccccccatga gccatgggca ctgactgggc

85141
gaggagtgca gctgttggca tgagacctcc ttctccccag cctggggaag cagggaccag

85201
cagataatcc cgcccttccc tgagctgttg ctgttccctg ttgaagttcc ctgaagctca

85261
gccagctcat attttataaa aatgaattaa aacctccaaa aaaatcaagg ctaatatgag

85321
gtctgctccc agccccctgc caatgtcctc cttgtcatcc ctgtcttgtg actataacca

85381
caattaaagc ccatagcctt tgcagtgtga cctgggtctg cagttatctg caaggcttcc

85441
ccctaaggag ctggggtaca agctgacctg tgtttcctgt gggacctggg tctcacagcc

85501
ctcccagtgc tctcagagcc agagccactc cctcttcccc caggcatctg ttcccatccc

85561
ctgccacagg ctccagcatt ctggagtgac gtcaggatct tggcacatcc agtcctaggg

85621
tttccctctg tctctggcca gccctgagcc ccgtagccgt gagttctgcc caggccctgt

85681
gagctcacca gagccacaga ctcacagccc agaggtggct tcttccttca ggaactgaag

85741
aacccccatg aacaccaaca tctccaggtt ctgagaacag aacctgggaa attgatgact

85801
tcctcatgat gaccgatact caggatggcc ctagcgagag ctcccagatc atgaggtccc

85861
tcactcccct gatcaacagg gaggaggcat ttggggaggc tggggaggcg gggctgtggc

85921
ccagcatcac ccacactcct gattcacagg aagaaggcct gaacgacata caggagatga

85981
tcaaaacgga gaagtcctac cctgagcgtc gcctgcgggg cgtcctggag gagctgagct

86041
gtggctgctg gtgagaaggg aggggcggca ggtgggggga ggatgaggcg gaactggaca

86101
aaggggaccc tgccagggct gggcagatga ggaagaatct acagagcccc tgctggtcag

86161
gctcgctaaa ccccggctcg ccctaccccc agccgcttcc tctccctcgc tgacaaggac

86221
cagggccact catcccgcac caggcttgac cgggagcgcc tcaagtcctg catgagggag

86281
ctggtgagga cgcaactgga cggcgggggc tggagggagg gcctggttgt gagaaggtgt

86341
cacaaccccc tttgtcatgg cccgagctgt cccccagttg ctgggttcac tgacaccccc

86401
tccttcgcag gaaaacatgg ggcagcaggc caggatgctg cgggcccagg tgaagcggca

86461
cacggtgcgg gacaagctga ggctgtgcca gaacttcctg cagaagctgc gcttcctggc

86521
ggacgaggtg cggcccaagg ggtcggggct ttgcctcatc cagggctggc tctctggggc

86581
ccctcaggat cagggggctc aatcaggagg ctagaccccc ttacccactg cccctggcca

86641
ccccccaacc cccagcccca gcacagcatt cccgacatct tcatctggat gatgagcaac

86701
aacaagcgtg tcgcctatgc ccgtgtgccc tccaaggacc tgctcttctc catcgtggag

86761
gaggagactg gcaaggactg cgccaaggtc aagacgctct tccttaaggt gctggagggg

86821
gcaggatgga tgggggcctg ggtcctttca ggggagcagc agcccccacc tggggctgga

86881
agcctgagtg acagggtggg gccttcaagc agcaggtgct cagagaagag ccaagaatgg

86941
gaaggacgtg ggggaagggg tggggaagga ggtgggggaa ggggtggggg aaggggtggg

87001
gaaggaggtg ggggaagggg tgggggaagg ggtgggggaa ggggtgggga aggaggtggg

87061
ggaaggggtg ggggaagggg tggggaagga ggtgggggaa ggggtgaggg aaggggtggg

87121
ggaaggggtg gggaaggagg tgggggaagg ggtggggaag gaggtggggg aaggggtggg

87181
gaaggaggtg ggggaagggg tggggaaggg ggcatgacgg ccccctgccc atcctcctgc

87241
ctccaccgga ccccagccca gcgggatggc tgtgaagggg cagggcagct ctgaccaggg

87301
cctctgccgg cccctgcccc ttccccacct cttgggccct ggcagccgtc aggctcctgg

87361
tgaccccatg cccaccccca gctgccaggg aagcggggct tcggctcggc aggctggaca

87421
gtgcaggcca aggtggagct gtacctgtgg ctgggcctca gcaaacagcg caaggagttc

87481
ctgtgcggcc tgccctgtgg cttccaggag gtcaaggcag cccagggcct gggcctgcat

87541
gccttcccac ccgtcagcct ggtctacacc agtgagtgag gacccctcac tcgaagcctc

87601
acctgggagg gggccggagg ggctgcccat cctggaacct caggctgccc ttccccacag

87661
agaagcaggc gttccagctc cgagcgcaca tgtaccaggc ccgcagcctc tttgccgccg

87721
acagcagcgg actctcagac ccctttgccc gcgtcttctt catcaatcag agtcagtgca

87781
cagaggtgag ggcctgggag gagggagtgg ctctggcttt gagagcacca gaagcctgtg

87841
agcctgtggg gactggagcc tgtggggcct gtgagcctgt ggggcctgga gccacaggtc

87901
agccagtgcc ccggtttctc aggggaagcc ctgcagataa ctgcagcaga cgcgggtcac

87961
actggaaagg ctacgggctt tagctgtggt tatattcaca agacagggac gacaaggagg

88021
acattggcag ggggcttggg ccaaacctca tattagcctt gattttaaga tttctggaag

88081
aatcaagaca cctgtcactc ctgcccccag gttccgtgga agctgagtga gtaggggtgg

88141
cttctgtttg tgcatctgcc cccccctctg tcacttgtcc cctgtctccc catcccatgc

88201
tgcaggtgct gaatgagacc ctgtgtccca cctgggacca gatgctggtg ttcgacaacc

88261
tggagctcta tggtgaagct catgagctga gggacgatcc gcccatcatt gtcattgaaa

88321
tctatgacca ggattccatg gtatgggtgg gctctggtgc cagggacccc agcagcacca

88381
cacctggccc ttgttccctg cactccacct gcgctgaggc tgtgccctca cctccgccac

88441
ccacctgcag agctccttgg ccaggtgctg gctgggaagc tgggagtggg ggctgacatc

88501
tagctcctcc tgcctgcttg cggcagcctg accccttccc aggccagcac atcctcacct

88561
cctgtctcct acagactgag ccctggaggt gtgccagcaa gtcctgctgt cactagcctc

88621
cccaccccag ggctccccga cccctgccct cacctaccac aaccagtaac agccttgcca

88681
tcctccgtgg aggttctgga gcagggagta agggattggg gtgacccccg agagttagcg

88741
agccaccttc tcacatacca cctcagctgc tgaggtgccc agatagccct ggactagagg

88801
taggaggacc tcatgtctag tcctgagccg ggcatctgcc atttactgac tgcttggcct

88861
tgaacaagtc tttggtgggc cctgagactt ggtttcctca tctgtaaaat ggggtgatca

88921
cacctgtccc ttacaacaac tcatggcgct gtggtaagga ccaaacgaga tcacaggtgt

88981
ggacagcaag caccaagagg cttctgggtt gtctgttgcg tcagggcaaa gctgacttca

89041
tgggccggac cttcgccaaa cccctggtga agatggcaga cgaggcgtac tgcccacccc

89101
gcttcccacc tcagctcgag tactaccaga tctaccgtgg caacgccaca gctggagacc

89161
tgctggcggc cttcgagctg ctgcaggtgg gactgcaggg aagaggggct gaggcctggg

89221
gactggaggc tgggagttgg ggcctagggc tgggggctgg accctgaagg ctggggcctg

89281
gggtctgggg cctgggggtg gggcctgggg gctggaggct ggggcctggg gctgggggct

89341
ggggctgagg gctggggcct ggggcctggg gggttagggc ctgggcgtta ggtcctgggg

89401
gttggggcct ggagctgggg cctgggggct ggggcctagg ggcctctctc ctacccatcc

89461
tgaccaaagc tgggggcgtg gtccttaggg ggtttccctg tctccccaga tcatggcaaa

89521
caactcatgg ggaaagagac cctgtccctg ggctccccag tgtgtgacct gtgaccccca

89581
ttccccagat tggaccagca gggaaggctg acctgccccc catcaatggc ccggtggacg

89641
tggaccgagg tcccatcatg cccgtgccca tgggcatccg gcccgtgctc agcaagtacc

89701
gagtggaggt gcgagggctc tgtgtggccc ttcccttttg gatgaggagt ctgaggaccc

89761
aggaggggaa gtggcttgtc atccccctcc caccaccatc accaggagcc agcagcagac

89821
ccaggctcct gccccagccc agggcctgcc cccatctgca ccaagtcgca ctcccatgtc

89881
ccaggaccat gcccagccct cctgtctgca cccctgaccc tgcacccctt ctccgggcag

89941
ccccaccctc atccctggag aacgcctgcc cctcctctgc tctcctggcc ctgctcccac

90001
cctttgaaat ctggggtgaa ctactgccca tcccactgcc cggttcccta ttggatggtc

90061
cagcaccccc atggctggct cccttgacta aggggctctc ttctctgcac ccaccctcca

90121
acctctccca ggtgctgttc tggggcctac gggacctaaa gcgggtgaac ctggcccagg

90181
tggaccggcc acgggtggac atcgagtgtg cagggaaggg ggtgcagtcg tccctgatcc

90241
acaattataa gaagaacccc aacttcaaca ccctcgtcaa gtggtttgaa gtggtgagtg

90301
caggccctgg cggaggacat cctgtggcca gtgtggctcc actcagccag ccggcttcct

90361
ctgccccttc ttggaggctc aggctcctgt cgccaacacc ccaggacctc ccagagaacg

90421
agctgctgca cccgcccttg aacatccgtg tggtggactg ccgggccttc ggtcgctaca

90481
cactggtggg ctcccatgcc gtcagctccc tgcgacgctt catctaccgg cccccagacc

90541
gctcggcccc cagctggaac accacgggta tggccacatc caccctgcca ccaagcctgg

90601
ctccacgccc cccagggaag ggctccaggt ctccgcccag tccaagccgc gaccagagtt

90661
tgctctttgg ggccgagggg gtgggcatag aagaaggtca ccctggtggc caaggaaggc

90721
tgcccaaggt gacgccagct ctacagccag agagggcaga actggagaca gcctgggggg

90781
gcctgagggc agaaagcccc ttgcgctggt tgatggagaa gacccaggcc tccccgccac

90841
ctccctccca ccggcctccg cagcttcccc ttatctcggg ctctcttctt ccctccccat

90901
gcccatattt tctcccttga ctgcctgtcc ccctctccct cagaaagttc cagaatcagc

90961
tttagttctc cgcaccttcc tgccccgcca atctcactgt tcctcttgct ccttcctctg

91021
cctgtctgtc catctatcca tctgtccagt caggcttctc cggcgctgcc gtgtgctgtg

91081
caatgggggc tcctcctctc actccacagg ggaggttgtg gtgactatgg agccagaggt

91141
acccatcaag aaactggaga ccatggtgaa gctggacgcg gtaaggcggg tggggtcagc

91201
cccctgctgg ctgggaacat gcaacttcgt gtgacacatc ctgtgaacca gactatctgc

91261
cccgagagaa aaggacacta agagcctcct ttggcatgtg actgtcgggg gctgagcttg

91321
attgtgtgtc caaacagctc cctcctaata ctatcctgga atgcacacgc gtgcgtgtgg

91381
tatgtaaatg tgcatgtgtg tgcgcatgtg tgtggtgtgc atatgtgcat gtgtgtgtgc

91441
atgcatgtga tgtatgtgca tttgtgcgtg catgcgtatg tgtggtgtgc atatgtgcat

91501
cgtgcatgta tgcatgtggt gtatgtgcat gtgtgtgtgc atgtatgtgg ggtatgtgca

91561
tatgcacgtg cgtgcgtgtg gtgtgcacat gtgcatgcat gtgtggtgta tgttcatatg

91621
cacgtgcatg catgcatgtg gtatgagcat gtgcatgtat gtgtgcatgc gtatggtgtg

91681
catatgtgca tgtggtgtgt gcatatgtgt gtgcatgtgg tgtgtaaatg catatgtgca

91741
tgtgtgcagt gtgcatgcat gcgggtggta ggtaaatgtg catgagtgtg gtatatatgc

91801
atatatgtgt gcatgtgcgc ttgtgtgcat atgtgcatgt gtgcatgtgg tatgtaaatg

91861
tgcatgtgtg catgtgtgca tgtggtgtat gtgcatatat gtgtgcatgc atgcttgcgg

91921
tgtgcttatg tgcacatgcg tgcatacatg tgggtgtgtg catgtgcact ggcatgtggt

91981
atgtgtgtat gagagacaga gtgagccatc acagtttatt ataatcacct gctataattt

92041
ttactccaac aaatgacacc ataggtaatg attccttatg agatcatcag tgtcctttcc

92101
aaagagtccc tggttttcca tcccagccat tcacaaatga cacttccctg gcctgggtca

92161
gaggaggatt tccaggtgga agctccttat tcctcctggc tttgggccta ggactgttca

92221
tctgccagag agagaactgc catctggggg ttgggtgtgg aagtggcgta caagctgtag

92281
accctacagg gaagggcaga acgtgggcca gcctggaaca cagcccactg ttcctttggc

92341
cacccaaaga aacatcctca ctcagaccct ttgcagactc accagtcaga gtgctcttat

92401
taatgcaaag ttggccttgc gggcacaggg gctgccagca cacagtaatt tccatctcgg

92461
ctcctccaca caccctgtgc taggccactg cctgccactc caggccccag tggctgattc

92521
tgcccctgtc tccttggttc ctctgcagac ttctgaagct gttgtcaagg tggatgtggt

92581
gagtgtgggg gccatgcagg ggctctgggg tgagagggtc ctttattggc aatgatgtca

92641
ggccaaaggg tccagcatca gggacagagc cagccccagc ccccgcatgc ttgggccagc

92701
acacctcccc taagatgcag tggaaaagag ctgggtgagt gcaggactcg gtgccagtcc

92761
tgcttgggcg agtggatcgc actggcaggt cacaacactc tgtggcctgt ggcaccttct

92821
ccataaaata aggccctgcc ccttggacat gggtggcccc acagagcctc atggagccca

92881
aggcttcctg ctgacagatg gcggaatggg tggaggctct cgggattgtc caggcaggag

92941
gagtccatgt aggactctgg acctggccaa cctgcaggct gaggaggaga aggagaagaa

93001
gaagaagaag aagggcactg cggaggagcc agaggaggag gagccagacg agagcatgct

93061
ggactggtgg tccaagtact ttgcctccat tgacaccatg aaggaggtga gacctcgggt

93121
agggtgaggg gaggtgaccc cctccacact cagaccctcc tgtccagctt ctttcccacg

93181
gcccccaaga gctggatccc aactccattc atgtgagttt gggatggttt tgtctcacat

93241
ccttgaaatc ctagctcaga actcaccttc caagatgatg gtcccatcta ccttccctgc

93301
ttggttttct tttgtcctca ttgactcatt ccacaaatgc ctcttgggta tatgcgatga

93361
gccaggctcc atactaggtg ctatgggagc caaaagatgc cacacctgcc ctgatgggcc

93421
tccggtttac tgggcaaaat ggacatgtaa acagagactt agagaggact atgtgataac

93481
aaaggcaaat catggcttgg gggaatcagg gaaggcgtct cagaggaggt gacctttgtg

93541
gaaaaggaga aacatgttct cagaggccat aagggaacaa ctgcttatca gtagtcctta

93601
cgactcttct tcataatgtt ttattttaca catcttggtc atcggcacgt gaatgattct

93661
tcccctatta cacatatgtg ggttccatct gtttggccag attgcaagtt ccagaaagcg

93721
catttctctg ctttcttgtt tgtgtcctct ccacgctgcc tacctagctc agggtgctct

93781
gactggccac ctgaccagga gggacacatg cctgcagttg tgtttcctca gtggggccag

93841
agctgatcca gccacatcct ctcccaggcc ctttctgtga cccaagctag gtgtgatatt

93901
tattagagca cacattaagc tgctgtagca agttagagtg aagtgaacaa gacagcagtt

93961
tatttctcac ataacatctc agagagtggg ggttaggctg gtatggtggc tcagtggtgt

94021
caaggactaa gatcctgacc tcttgtttgt cacatctgta aggttggagg tgactcaaca

94081
tcatgttcta attcaagtgc acaggaaggg ttaaagagga gatgaggcat atgcttttct

94141
ttttcagggc ccaatccaga agctgcacat atgacttcca ctcacattga tcagaatcta

94201
gtcccttagc tacacttatc tgcaaaggag gctgggaaat gtaatctttc acaaggtggc

94261
tgtgtgctca gcaaaacttg taaaaatagg agaacagatc attgaggaca actggtagtc

94321
tcgtctccca ccatcaagtt ggccaggctg gagctgcaag aggctgcctg ttgtcgtctc

94381
tactcctgca attttcacag actgccacca ggtggcggtg gcgacttagt tgaaacctgg

94441
tttctagttt ctagtaagat ttattctcgt ttccagtaag atggggtgtg ctgagtgaaa

94501
gaaaatatag tacattttct tactgttata cttttgtaca ttaaaacaat ttattaatat

94561
cactaaaagc aacattaaaa tgcactgtac ttttttaagt agaaaatgta aatatttatt

94621
gcaaggtgtt atttcttttt tttttaaatt atactttaag ttctagggta catgtgcaca

94681
atgtgcaggt ttgttacata tgtatgcatg tgccatgttg gtgtgctaca cccattaact

94741
cgtcatttac agtgggtatt gctcctaatg ctatccctcc cctctccccc agcaccacca

94801
caggccccgg tgtgtgatgt tcccctccct gtgtccaagt gttctcattg ttcagttccc

94861
tcccatgagt gagaacatgc agtgtttggt tttctgtcct tgtgacagtt tcttcagaat

94921
gatggtttct ggcttcatcc atgtccctgc aaaggacatg aactcatcct tttttatggc

94981
tgcatagtat tccatggtgt atatgtgcca cagatgcata aacccctaag taccactagt

95041
cacactgtac acattataaa ctttttttaa cccacttaag cagagcacat ggtggacttg

95101
aaatgcagta gggaagattt tctacttcta gtgcattaag actggtctgg gcccacaatt

95161
tggggtcaac agactcctcc ccaggaaacc caccttctgt ccttttcatc tcatcttttg

95221
gcagcaactt cgacaacaag agccctctgg aattgacttg gaggagaagg aggaagtgga

95281
caataccgag ggtgagccct ggaacctgga actctgcctc ctcctccccg cccctgggtg

95341
gtcagctctc ctgcccacct catcacctgc ttctcttttc cctcctgcca gccctcccag

95401
ccttagtagc cagggaagca gcatcagtaa tccatgggca gtactgggca ggctaaggcc

95461
cttgtccagg gaggctttta ctctgaccag ttcagcaccc acagtgatgg gcagacattt

95521
agagccacag aacatcagag ctagaaggga cctcagagct cattccatcc agcattttcc

95581
agactctttt ccatgaagaa aattgatgga tgttctagaa ggaacaaatt agttttggtc

95641
aaattagttt aggaaaagct gattgaaaca gcttgttttg gtgcaggact tttcataccc

95701
tttactgtgc aaatgttatt atacatctct aaaaggaaga cacagtataa aatatttccc

95761
cagcttattg gatcacagta ccctttcttc taaagcatgc cagcagcatc tgcaccaggt

95821
gctccactga atgaggtttg ggaaatgcta atacagagtg ttattattat ggacaagaag

95881
agggaagcta gtgaggaaag tgagtgggca aggaactgcg cagcaacagg cctccacccc

95941
caaacccatg ctccttcctg cccctctctt ccaaagggca tgaagacagt cttcagacac

96001
cttcccgggc ataaacccac tggggccccc agcacctcca tgaggcgggc atgctaggga

96061
gtattatctg catttgacag cacatggaca tccgagagtt aagttagtaa agcaaattag

96121
cgacagagct gggtctcgaa tccaggcctt cctgctctgc tcatttctgc tccacctcct

96181
tttctgcttc tggccaggcc tgaaggggtc aatgaagggc aaggagaagg caagggctgc

96241
caaagaggag aagaagaaga aaactcagag ctctggctct ggccaggggt ccgaggcccc

96301
cgagaagaag aaacccaaga ttgatgagct taaggtgaga gcctaggagc agacccttct

96361
agggtgtgtg ggggcgggaa gaggggggcg cagtgatcct gcaggtgggg caggacaaaa

96421
gccagagacc aggcagccgc cccctaacag cctggtctgt ctcaggtata ccccaaagag

96481
ctggagtccg agtttgataa ctttgaggac tggctgcaca ctttcaactt gcttcggggc

96541
aagaccgggg atgatgagga tggctccacc gaggaggagc gcattgtggg acgcttcaag

96601
gtcaggccag gagcacgggc ccagcctgag cacccgccag cccttgcccc ccccacaggt

96661
tcccccactc acctcccacc actgccccgg ccactgcctc cagaagccct ggactctccc

96721
atgactcagc agttaaaggg tgaaggccct gccacatcag ggtccagccc tcctggtgct

96781
gttagctatt ttgaatgcca cccttgccag gcaaacctac accctgaccc acatttgtct

96841
tgcccagggc tccctctgcg tgtacaaagt gccactccca gaggacgtgt cccgggaagc

96901
cggctacgac tccacctacg gcatgttcca gggcatcccg agcaatgacc ccatcaatgt

96961
gctggtccga gtctatgtgg tccgggtgag actcccgtcg ctttccctcc ttgcaagtct

97021
cctcatcctc ccatctggga gagagcaaag aagctgcata ctggccaggt gcaatggttt

97081
acgcctgtaa tcccagcact ttgggaggcc aaggcaggag gatcacctga ggtcaggagt

97141
tcgagaccag cctggccaac atggttaaac cccgtctcta ctaaaaatac aaaaattagc

97201
caggcacagt gccacgcacc tgtaatccca gctactgagg aggctgaggc aggaaaatcg

97261
cttgaacctg ggaggtggag cttgcagtga gctgagatca cgtcattgca ctccagcctg

97321
ggagacagag cgagactctg tctcaaagga aaaaaaaaag aagaagaagc tgcatactga

97381
cagccccaga ctgggaggca ccagggagat catttggtct agtctttatc ttttctagag

97441
gaagaagtca acgcccagag aggggtagcc acttgcctag ggtcacacag caagcctcct

97501
gaggggtcca gtgctcctgc ccctgccctt cactgtcata ggaccctcag gcagcctggc

97561
aggggcactg aagatgagca gggcatggga gcctgctcag gcagcccttc tccccattcc

97621
aggccacgga cctgcaccct gctgacatca acggcaaagc tgacccctac atcgccatcc

97681
ggctaggcaa gactgacatc cgcgacaagg agaactacat ctccaagcag ctcaaccctg

97741
tctttgggaa gtaaggcttc ttggtgccct cccctgccac acccctactt ctccaaccca

97801
gaacacctcc caccctagcc aatccttaag cccttctcct aactccaccc caccaggtcc

97861
tttgacatcg aggcctcctt ccccatggaa tccatgctga cggtggctgt gtatgactgg

97921
gacctggtgg gcactgatga cctcattggg gaaaccaaga tcgacctgga gaaccgcttc

97981
tacagcaagc accgcgccac ctgcggcatc gcccagacct actccacgta tgtggggcat

98041
ggggcagagg gcgggggcag tgtgcctgct ttgcctccac tctaaaatga gattcagatc

98101
ctggtgattt gagaggttag acattgtggt ttctgtccca ggccaggcct ctgcccctac

98161
agtccctggg cacagtcttc aggggacagg actgcagatc ccaaaacaag gagagggaca

98221
gtggattcca ggacagagga ggcaggacga ggagagacaa gtgggctagg gaaggtgggg

98281
gctagcaaga ggaggacaga aagagtcccc tggggatctg ggccagctct gccacttata

98341
ggctgtgtga ccctggccaa gtcccttcac ctctctggtt ttcagtttcc tcatgggagt

98401
ctctgaggtt ccagaggagt gggcacagtg aggggatgca gtggggctag gctggggaca

98461
ctgatatgtg gtccaaggcc cagggcagga aggttcagcc tccagcagcc ctagtgtctc

98521
aggtgagcct ggggcccagg gcaggaggaa tcaggctcac ttgctgatga gggcaacagc

98581
caactttaga gaactggcca cgaccagctg tcatccagga tggcttagtc ccacccagcc

98641
cctccaagcc tgtgtgtccc ctcccacaga catggctaca atatctggcg ggaccccatg

98701
aagcccagcc agatcctgac ccgcctctgc aaagacggca aagtggacgg cccccacttt

98761
gggccccctg ggagagtgaa ggtggccaac cgcgtcttca ctgggccctc tgagattgag

98821
gacgagaacg gtaatggggc actggatgca gccgcctgcc ccctctccag ggggtttcag

98881
aggccaggag gggcccacac ttccctgggg aacctcacag cctagcctgg ggtgtcctca

98941
gcctaaacct ggtcttagtg accctctgct catcacccca gagccccgtt cctgtctgcc

99001
cagcctctgt gcttccaccc ctcctacagg gcagccccac ctgctttctc tctgtccaaa

99061
tcccagtgag gtagagaggc tatctgcatc ccattctgca gataaacaaa ccaagatcct

99121
acttctagtg actcgcccaa ggtcatgtgg ctctttagag gcagagcgag ggcatcggcc

99181
caggtccatc tggctctaat ccttaaactc tccttacttc tctgtccatg aggcacttcc

99241
cagagaagca gagaattggg aggtgtctgt gctggtatct gatcactttc aggtgctggg

99301
acaggaagtg gattctcccc tccctgaccc ttctctcagc ccagcagggc tctccagtca

99361
acttccccaa gcagaggacc aagggcacag acctctcttg gccctgtggg gcagctgaga

99421
ccctgggcaa gccacttctc cttctgtgcc tcagtttccc caacagtgaa aaggaggtgg

99481
ggtagacagg tgatggcata gaggcttctt tgtgctccta agtccctagt cccagcaaag

99541
gtcttctggt tctgctgagc catgtgtgca gctgagccgc cggcacccac aggtcagagg

99601
aagcccacag acgagcatgt ggcgctgttg gccctgaggc actgggagga catcccccgc

99661
gcaggctgcc gcctggtgcc agagcatgtg gagacgaggc cgctgctcaa ccccgacaag

99721
ccgggcatcg agcaggtgac acttgcatgg ccaagactgg ggttcttggg tattggggac

99781
cagggatccc caacctgagt cagtaaaggt agaagccagg cctcacgctg tccgctgcat

99841
tccagaaagc ctggcaggca ccttcccacc aaggcccctc agggtaactt gaatggcaag

99901
ggtctttgct ttgagtgaga attacatcag ctcaggcaga gacctgggtt gtctccctca

99961
gaagctgtga ttggctattg gtgacatcat aggaattcct ggcatccaaa gatggaaact

100021
gatgaactgg gtccttgaca gaacaaaggt taggagggag aggagagctg atcttcctgg

100081
gcagagggag aaggccctgg gagatctgcc acaaccctct tcctcagggc cgcctggagc

100141
tgtgggtgga catgttcccc atggacatgc cagcccctgg gacgcctctg gacatctcac

100201
ctcggaagcc caagaagtga gcggcctggg gcccagcgct actcccttcc ggcccacccc

100261
acccacttcc caccacggcc caacccttcc tgcggggggc tcaggtccag atggccttgg

100321
ccagttggca tccctggggc ctgggtgtgg ccactgggcc ttatagggga gaaactgacc

100381
aaccaatcga tagagtttag ggcctgccct ggagagtccc cacgtgctaa ggcaggacaa

100441
cgccttccac cctgcatcag tgagcgagac aagccccaca cagcacactc cggtgcattg

100501
tatctacacg gtctacgcgc ccatacacat gcatctcatg cacacacaca cacacagcat

100561
agcactccca cggacaccca cacacatgcc cacactgacg cactccttca caacacacag

100621
aacccctggg agccggccct gcgtcatcct cacatccagg ctagtgtgat gttccgccaa

100681
gttttctttg gagtgcctgc cagtgatgaa tccaggagtg agtgcctgga agaggcagga

100741
ggtggtagag tgaaaagaac ccgggtttcc catccataaa gcggcaggtt caagtccagc

100801
tgtcagacag tgactggatt cagggccagc ttcagggatg gaggaagcca cacagggtcc

100861
cactcttgtt tccatgctcc tatgttgcca tcttgaaatt ctttatgaca agtgaccctg

100921
catttccatt tggcgctggc cccagcaaat catgcagcaa attctgccag gaatgtcctg

100981
gaaacctgag gccatgagtc agctgttcca gggcctgtca ttagggggca cccaactcac

101041
tgggccactc tgggctcgca gccctgtctg caatcccagg agagccatgc tcagatcaat

101101
ttttagtgaa tgactcagcc tcactcttaa tgattgaaat gaactacatc attcataatt

101161
acaattaaac cttgagggga aaatcctctt tggggacagg gacatacagc ttccatgggc

101221
ttccattgct ggctactggg cttaaatgca gacttctctt ggaactagca tctgagacag

101281
agggtggctt cctcccctca ccccaccccc accgcccaca gccatgtgcc tggtgggcct

101341
tctcactcat gcctctgctc ccccaacccc aaaccactcc tccagcccca gcctggccca

101401
ggccctgtgc tgaccccaag accccagggc ttctctccgc ctgccccatc ccagccctgg

101461
caccctggca taacccccac ctggggctgc taaccagcct tctctccctg ggcccaggta

101521
cgagctgcgg gtcatcatct ggaacacaga tgaggtggtc ttggaggacg acgacttctt

101581
cacaggggag aagtccagtg acatcttcgt gagggggtgg gtgagcagtc cctgcatggg

101641
agggactgag ctgggtgggg cttgcttccc ggggggcagg agaggaggca gagggaaggt

101701
ggctgtgggt gggagaggcc ccaccagcct ggctgcgggt ctggagatgt ggcgcccaca

101761
ggtggctgaa gggccagcag gaggacaagc aggacacaga cgtccactac cactccctca

101821
ctggcgaggg caacttcaac tggcgctacc tgttcccctt cgactacctg gcggcggagg

101881
agaagatcgt catctccaag aaggagtcca tgttctcctg ggacgagacc gagtacaaga

101941
tccccgcgcg gctcaccctg cagatctggg atgcggacca cttctccgct gacgacttcc

102001
tgggtgcaga gcagggcagg gatgggggtt caggatccag aactgagaag aggcaggggc

102061
cgggttggcg gggacaggga gagccctgcc ttggggggac aaggggtcat tgcttccagt

102121
ccatcagagc caggggtgtc cgacggggtt ccgcccccaa ggacccacct aaccgtccct

102181
aggcagatgt tctcagtgtc ataaccaggc tgacaacaag ctttggacac accaaggagg

102241
gggcagtcag tgatgatggg ggaggggaga ggctccctaa gggagtcggg aaacctccct

102301
gggcctcagg ttgcttctct gtaaagcagg gattctccct aaaactctaa tctgcatctg

102361
caaaagcttg tgggattagc aggactttga cagaatggat gcatggcagg gagtggcagg

102421
ggagacccca ggagagaccc tctggggtga aagaaggacc tgagtaaagc atgggggctg

102481
gggctgccta gcaagcccac gaggatgcct gcattgaggc cagttgctgg gagtgaggca

102541
ggaggatgag atgtgggctc agggaggtct gcactcagca aacaaggggc cgaggagccc

102601
agacccccac ccccaccccg ccccacccca gccctgttca ctctgagctg acactgaggt

102661
tgccacaggg gccatcgagc tggacctgaa ccggttcccg cggggcgcaa agacagccaa

102721
gcagtgcacc atggagatgg ccaccgggga ggtggacgtg cccctcgtgt ccatcttcaa

102781
gcaaaagcgc gtcaaaggct ggtggcccct cctggcccgc aatgagaacg atgagtttga

102841
gctcacggtg cgcacccctt cctgctcggg cagtaggcag ggctgggact ggctggggtg

102901
ccaagggccc agcacgcagc ctggacgctg ggacctgtct gtcctctgca gggcaaggtg

102961
gaggctgagc tgcatttact gacagcagag gaggcagaga agaacccagt gggcctggcc

103021
cgcaatgaac ctgaccccct agagaaaccc aagtgagtgc cctgccggcc cagcccctcc

103081
ccactctggc tcttggaggc gctggaacag gaaggagacg atccccagac accccatctc

103141
ttcctgggcc acagcctcat tacaggggag cctcctccct gccctctgcc aaccctgaat

103201
cccacaacgt ccctttgaac cagaggatgg gctaggaata ctggagagca ggaccttccc

103261
tgggaaaggc cccatctagc ggagagaaac tatgctcttc ccttcctagc ttttgcagaa

103321
gagccagctc cagtggtggc ctctggggcc atggccagcc ttgatggcca gaggggtgcc

103381
tagaactgca cacacagccc aggacagctt ccctcttggt cttggcccct cgccacaccc

103441
aatcccttct cctccctgtc cctcctctgc gctctctacc cttcatactc cagccggccc

103501
gacacgagct tcatctggtt cctgaaccct ctcaagtcgg ctcgctactt cttgtggcac

103561
acgtatcgct ggctgctcct caaactgttg ctgctcctgc tgctgctcct cctcctcgcc

103621
ctgttcctct actctgtgcc tggctacctg gtcaagaaaa tcctcggggc ctgagcccag

103681
tggcctcctg ggtctgatat ttcttacttc ttcctctgga ccaagggcta ggcaggcgcg

103741
tgcacacaca cacatataca cgcacacatc cacaaacaca aatatgcata catgtgcaca

103801
caaacacaca caagcatgta tgcacacatg tgccacgcac aagtgcatac acatgcactc

103861
aagcacacac aggcacacac ttaagcccac acaaacatgc acagcaactt tcaagctttc

103921
atgacagaat agactctcag aactagaaat gactatttta cacttttcca cattaagcca

103981
aagaggtgaa gtagcttgct caaggttacc cagcaaatta gggtagagcc gggactcaag

104041
ccaaggtttc caaatttcca atcctgtgtt ctttgcacac cacctctgct cccagccatg

104101
tttctcccag actgtaaccc aatttttttt tttttttttt ttttttggag acagagtctc

104161
gctctgtcgc ccaggctaga gtgcagtggc acaatcttgg ctcactgcca gctccgcctc

104221
ccgggttcac gccattctcc tgcctcagcc tcctgagtag ctgggactac aggcacccgc

104281
caccacgcct ggataatttt ttgtattttt agtagagacg gggtttcact gtgttagcca

104341
ggatggtctc gatctcctga cctcgtgatc cgcccatctc ggcctcccaa agtgctggga

104401
ttacaggcgt gagccaccgc gcccagccga ctctaaccca atttcattgg cagaaagaag

104461
ctgagctatg gacagggaaa agggaagggt gtggccaggg ttagccaaca ggtctggaaa

104521
tggctctcac ccgtgtgtga cctcccagtc cagggctgtt gttttctgcc cttcaggata

104581
ataattccat tcaactcaaa catttcatag ccaccatggc ctgaacaccc aactgcaggt

104641
gctcagagct ccccaggcac tggctcactg tgccattgcg ccaaacccag gaggtaggta

104701
ctgcttgtaa ccccatttta tacatgaaga aaccgaggtt gatagaggtg cctcacttgc

104761
ctgtgaaaac cattcaaaac caggtgccct gcacccaagc cccggctctg tgtccccacc

104821
aatactgagc tcagctctgg ggctgcacgc catgtcctct gggaggcagt agtttgaaaa

104881
tgcatatgca gtactttcac ttgtatcttg acattttaca aaacctattg tttttataac

104941
acaaacgaca gatagtgagg ctggccaggt gcttctcggc tgggaggctc tacagaaggt

105001
ggagtgggtc ttcatcctga gagtgggcag gtcggtgagg gcagcttgca ccccacaggg

105061
gctgctcaga ccctcagcag ggcccggtgg gaacagccat ttatgtccat cagaaaggaa

105121
gaggttgtga agcaccagtc ttaccaagga cgtggggcag cacatagaac gagctaaccg

105181
caggagcttc ctaacgatga gaactgcctg cagggccaag gctgccccat gctgcaagta

105241
gctcccatct aggccttagg aggagattcg ggccccaaag gtgctgcagg gaggatagag

105301
ttttgtaagc agcaagtcgg gtacttagaa atgggtttaa accctggctc cagcattcac

105361
tgcttttggg gctggggcca tggcagggct tttgggggtc cagaaggaca gaggatgggg

105421
tgcactggga ggcagctcct gcccactggc tgaccggctc ctctcttcca cttcccagcc

105481
ggcccgacac ggccttcgtc tggttcctca accctctcaa gtccatcaag tacctcatct

105541
gcacccggta caagtggctc atcatcaaga tcgtgctggc gctgttgggg ctgctcatgt

105601
tggggctctt cctctacagc ctccctggct acatggtcaa aaagctcctt ggggcatgaa

105661
ggccgccagc tcccgccagc cgctccccag ccctgccgca tttcctttca gtggcttgga

105721
ctctttccca tctcccctgg ggagcctgag gagcccagcg tccactcttc atgccttggg

105781
ccgagcctgc ctcctgcttg cgggggccgc ctgtcctcac tgccccaggc tgcggcttgc

105841
ccagtcccgc ccctctgacc cctgcctgtg ggctggggag ccttggatgg ggtggggacc

105901
tggaatgggt ctctcttgcc ccacctggct gaggcgccac ccttcttcag gcccaggctc

105961
cagaggaaga ctcctgaaac cctccccagg tcttccaagt acaggattga agctttagtg

106021
aaattaacca aggaccatgg gtcagtgccc agggctttaa aaagaatgaa cgagcaaaag

106081
gtatccccgc cgtgacccct gcagatagca ccggtctttg atccgcagca ggggccagac

106141
cctgcccaca agtcccagcg cggctgcttc tgccactgct gggctccact tggctcctct

106201
cacttcccag ggggtcgcct gtcctgcctg tgggtttcca tggcttccca gagctccctc

106261
tgccccagcc agcgcctcca ggcccagctg aggagctgtg agaagcagca gaggggactc

106321
cccatcccgg gcacaccctg tcctcccacc cctgccccct tgcccttcca gccctttcag

106381
ctgcagctgg gagctggccc gtcaagtgct gcccctgcct gtgtctgggt ttctgttggc

106441
tgtttttctt ttcttgagtg gtgatttttc tctaaataaa agaagtcaag cactgagctg

106501
acaggtctgc actggtcaag ctgagaggag cagccgcagg tgcggggcag aggcagcagt

106561
tctctaggct ggcagattca gtaccagcag ggctcccatg gcctttcccc ttcaagtggc

106621
ctctggtggc ccagggttca aggcaggcct caggcacagg gctgcccacc caggctgccc

106681
acaggaggag tcttacacca tagcccaaag ggcacaccag cctgggccca ggggccccca

106741
aagcaccgaa agaatccttc aggtctgggg ccagtctgaa ggcttaaggc cccacaaggg

106801
cccaaaagct ctagcctcca cccacagaaa ccagttcccc tgaaagcaag aaaggagccc

106861
cacgctactg gcctcggcct ctgactcaca ccactatctg agcctggggc aaagtcccct

106921
catgacacag aggtaggggc aagggcctgg tcttgctaga cctgacctct ttaaagagat

106981
tcagccacaa ctttaaaagg ctttaatcat aatgcaggac acaggtaact cctctggctc

107041
cttatttcga caggctataa agacagccct ggaaaatcca gagagcaggc ccaggtgcgg

107101
cccagtgggt gatatgagct ggctccggca cagacaccag catcaggcca gccctaacac

107161
atcagccttt ggcggtccag ctcattttgt gggtacccgc aacacctgag tgggaggaac

107221
ttgcagttca gagttgatct ggaaaagaaa gggtgaaagt cgttacattt ttcccagggc

107281
cctccttctt tgccaccctt gcgagccacg ctggctctcc catgggcctc caaagccctg

107341
cacgcatctc ctctccaaag ctgagagatg ctgaacaccc acagactgcc tccctgcagg

107401
agacacgcct gagccttctt gctcagcttc tgctccagct gtgacctctg gtagcgttct

107461
tcatctcccg cccgtccatt ctctgcagtc ttcccctctc ctctctccac gcacccatgc

107521
catccccaat ctagcctgcc ccacctcttc ctcccccagc ctcttgtata cagtagcatc

107581
tgtggaagcg ggaaccatac cgtccagaat gtctgggtcc tgtcacaggc caagggtcat

107641
tatgaggcca aggttcacta caacatccca ctttcagctg tggcctggga cctgggactg

107701
tgctggggcc acgcagcccc tgtggctgga cttggagctg gcctcagtca cctcacacgt

107761
gtgcaactaa cagctgcgtc acgaccttcc tggcctacag ccccagctgc aggtgcccac

107821
acccgcagag caggaaatgt cagcaatgga ctttttcctt cctcctcttg ccaggccatg

107881
gggaagttgt ccacaactat tgcagggttg ggcacagatg ggggccaggg aatatctgcc

107941
ccagcagagc ctccttcccc atgcgaggat gaccctccag tcatatccca ggcagggaac

108001
cggggctggt gggtggaaag agcccaggct ctggacgagt tgcaaactct gcaagttgtg

108061
attgtccttt gtgtgaaatg aggagcattg tttccgccct gtccacctca cacagcgggt

108121
gtgaggatgg aagaagagag cacagctgga ggctctgtag ctggggagct gctcctggct

108181
gtggcactgc ttcacacaga gcagtcccag ctggccactg gcaccagaaa ccacagtatc

108241
aaagagacac tgtcacacct gagctgtcct ggaggagact tcaggcaaga tctactcctt

108301
tggccagtag ttgtctcaag gtgccactct tgatttttta catcatatca caaagctccc

108361
ttgcctctga cggggagggg actcctcgtt ccctaatccc agctccagtg cccctgcccc

108421
acccgtgtct cccgctgccc ctccttggaa ggccccgccg cccaccttgg agttcagata

108481
ctgctgcagt agcgcc

Norrin Cystine Knot Growth Factor (NDP)

The NDP gene encodes “norrin cystine knot growth factor” (NDP). The human ND gene is located on chromosome Xp11.3. It contains 3 exons, encompassing kilobases (kb) (NCBI Accession No. NG 009832.1). NDP encodes secreted norrin protein that plays a role in retina vascularization of Wnt signaling pathway through (FZDA) and (LRP5) coreceptor. Mutations in NDP have been associated with Norrie Disease Pseudoglioma, an X-linked recessive syndromic hearing loss that is characterized by early childhood retinopathy. About one third of individuals with Norrie disease develop progressive hearing loss, and more than half experience developmental delays in motor skills.

Various mutations in the NDP gene have been associated with hearing loss (e.g., Norrie Disease Pseudoglioma). For example, the p.His4ArgfsX21, p.Asp23GlufsX9, p.Arg38Cys, p.Ile48ValfsX55, p.His50Asp, p.Ser57*, p.Cys93Arg, p.Lys104Gln, p.Gly113Asp, p.Arg121Gln, and p.Cys126Arg mutation have each been associated with Norrie disease pseudoglioma. See, e.g., Musada et al., Mol. Vis. 22:491-502, 2016; Chamney et al., Eye (Lond) 25(12):1658, 2011; Liu et al., J Chin. Med. Assoc. 79(11):633-638, 2016; and Parzefall et al., Audiol. Neurootol. 19(3):203-209, 2014.

An exemplary human wildtype NDP protein is or includes the sequence of SEQ ID NO: 20, SEQ ID NO: 21, SEQ ID NO: 25, SEQ ID NO: 26, or SEQ ID NO: 27. Non-limiting examples of nucleic acid encoding a wildtype NDP protein are or include SEQ ID NO: 21, SEQ ID NO: 22 or SEQ ID NO: 24. As can be appreciated in the art, at least some or all of the codons in SEQ ID NO: 21, SEQ ID NO: 22 or SEQ ID NO: 24 can be codon-optimized to allow for optimal expression in a non-human mammal.

Human Mature NDP Protein (NCBI Accession No. NP_

000257.1)

(SEQ ID NO: 20)

MKTDSSFIMDSDPRRCMRHHYVDSISHPLYKCSSKMVLLARCEGHCSQAS

RSEPLVSFSTVLKQPFRSSCHCCRPQTSKLKALRLRCSGGMRLTATYRYI

LSCHCEECNS

Human Mature NDP cDNA

(SEQ ID NO: 21)

atgaaaacggacagctcattcataatggactcggaccctcgacgctgcat

gaggcaccactatgtggattctatcagtcacccattgtacaagtgtagct

caaagatggtgctcctggccaggtgcgaggggcactgcagccaggcgtca

cgctccgagcctttggtgtcgttcagcactgtcctcaagcaacccttccg

ttcctcctgtcactgctgccggccccagacttccaagctgaaggcactgc

ggctgcgatgctcagggggcatgcgactcactgccacctaccggtacatc

ctctcctgtcactgcgaggaatgcaattcc

A non-limiting example of a human wildtype NDP genomic DNA sequence is SEQ ID NO: 22. The exons in SEQ ID NO: 22 are: nucleotide positions 1-87 (exon 1); nucleotide positions 88-468 (exon 2) and nucleotide positions 469-1719 (exon 3).

Human NDP Gene Sequence (NCBI Reference Sequence: NG_009832.1)

(SEQ ID NO: 22)

1
aagatgctcc gtggaaggga gccgagcggt gggcagaggc tgagtccccg ataacgagcg

61
cctcacattt ccgtggcatt cccatttgct agtgcgctgc tgcggccgca cgcctgattg

121
atatatgact gcaatggcac ttttccattt gacattctct ctctctctct ccctctctct

181
ctctccctct ctctctccct ctctctctct ccctgtgtcg cttaaacaac agtcctaact

241
tttgtgtgtt gcaaatataa aaggcaagcc atgtgacaga gggacagaag aacaaaagca

301
tttggaagta acaggacctc tttctagctc tcagaaaagt ctgagaagaa aggagccctg

361
cgttccccta aggtaagcag gaaaacaagc gctgccggct tgcctaggaa atcgcttctt

421
tccaaaccga gcatttcatc ctcctctcag acaaagagac aacctttaaa taccacttaa

481
atttgcatta ctttaatttg cattaatctg tagcatgcta gcattgtgtt tcttaaatga

541
acgggtcttt gaagtctgtg acagagcagg gagcctccta gaaaagcttg aaaatatctt

601
ttggtttgac ttaaagagat ttttcttttc aaactctctg cgtagttaga tgtaactttg

661
tgatggttct tatagttgac cccgtgaaag ggggctgcga agcagcaact tgccaacatg

721
gattcatgga gcccagtatc ttccccagca ccctcatccc acttacaatg ggggcactat

781
taacgcaggc aagactgcga gtttaaaagc gcactgttta cttttattac tacttatgta

841
tgctgctgat ctcctgccag ggctctgccg gagtgctcag aatgacttca aacaataggc

901
aacatttatt tctagctttc tgtgtcacgc tttgcaggaa tcctgctccc ttgcactctt

961
ctttcagcgt gcaggtcttc gcttccatag atgcattggg gagcaccggg aggagatgag

1021
gatggattta ctgtatgatt ttgattgggc aaaaagtccg aggaaatgca tgctgtttgc

1081
cttggactta ttgcaggggg ttatttttag tcatcagctc gtccctgcag catgatgttc

1141
aaggagtgac cgggaaagga tgctcccacc agcacagaga ccaggacctg taggaatgac

1201
tcctacctgc gggatattcc gaggtttctt tcaaactttg gaatacaagt tctctcttta

1261
aatgaacaat tgagctgtag gaggcctggg cataactctt tcttggggga cgggaagttt

1321
gattgtgtac agaatgttaa tgactcagaa cgcccagtaa ctgaggctca ttgtaataga

1381
caaacccaga taagcctcca tgagaggcag actcccatct ttactgagat tcaggtgcgg

1441
gaaaggaagc tatttggcaa gatgggagtc ccttgtacag ttctttgtaa ctcattaata

1501
acagatatgg ctgctgtgaa acatgtctct tttcatttct aatattagtg tattttaatt

1561
acaaggagct ggcattggca aattacccca acacataaga ttaaatacca ggtgcatttg

1621
aaaacagaga gatgactgaa atggggagtt gctgtgggtg tcaaccaaat acagcgggga

1681
cggcacaatg cttctcaact gagcgtttaa accagatgca aatatctgct cattttcttc

1741
tcatcagtct tactaattca aggaaacttt atggtcctgt ttgccagttt tcattgcaaa

1801
ttggtacaca gtttatgcaa aacttttctg attttctctg ataaccagcc caataagcat

1861
cgctgaatga aaatctgata tttgaatagg ttaatttaca actttggggt attcattagt

1921
caagaaagcc ataaaagaca ctatggattc cattgctgta aaattttatt gtaatttttt

1981
tttaaaaaaa ctgcggttag caaagcattt agctgaatca aaacaatttt cttagactat

2041
tattcagatc attacatgag agtatttgaa cacaaaatgc aatgttttgc atcatttatt

2101
ttaaaataca tttggttcag gtaacgggag aactggctga ggccttctta cgactgtgta

2161
ccaagcagct gacacccaca gatggaaatg tgcctgtgga gttttcaatc ttaattcgag

2221
ttccaatgac actgtcaagg gaaaaataaa tcatttttca atacatttaa caatttccaa

2281
ctcatttatt ttcctgggcc cttgaaaaat gtggtgagtt tcttggaatt atagccacca

2341
atggtggcca gcaatcttta ttttaagaac tcacaattca agtactatta ttctctggtt

2401
aattatttat ttcatcaatt tttaaataaa tatttattaa gcattttcta gatgcccagt

2461
gctatgctag tcccgatgga tgcaaaggtg aatgagacat tgtcccatac tctaattctc

2521
agtccatatg ccatctctag ttagattttg gaactgaaat gggcattgcc aatgggtaaa

2581
gtgggcaata actttcctgt tataaagaat tatttaaaac agctactggt ttctagattt

2641
acttgaaatg attctcactc atcagtgggt tttctttcca tttatgatta agggattccc

2701
ctttggcctt tttcaccaga tcctgggtac acgtcatttg cacagctaac acggctagat

2761
ctttccagcc tgggtagaag aatcccggaa aaagacagta gtttatcctt tctctgctct

2821
cctgagcacc ctgtggaaag gaccatatgc tgtctctatt ggggatgggt gtgagtcgcc

2881
tactcagtag ctaacatcag ggccacttga tgaatcatcg aattagaaac atgcatatgg

2941
aggaagatgc agtcactatc cctcaccact tacttgtccc acccccagta tcaaaacaaa

3001
tgacctctgg gcctggccta aattcaagag gcccctggga agaagctgtt ggaaactctt

3061
ccccaaaccc aggtctccat catagccaca cagtgttgct ttcaaataac ccagtatggt

3121
gttttatcac gtgtttaggt tactggggga aaaaaaaaac cctgaaaaca gcatcaccag

3181
ggtccttgac ttggtcctta tcagcagata atcccccgtg gttggattaa aatgcctctg

3241
actccctggg gtgcctgact caccctagcc agccctcagc ttcttggcca gcggccttcg

3301
agcccatcct cacctcttcc catgacggcc agtgactgct tctttgccca ggccctctgc

3361
actaggccag cagccagtgg gagcagaggg gatgggaagg caggtggaca gactgtgaag

3421
tgctaaggca gagcggggaa gcagggctgt gagacagggt gggtgagctc cagggcctgg

3481
gttgctgtgg cctgccctgg ctgtgatcag ctgtcatttc ctctttgtgt atgacactgt

3541
ggaacatatt aaaatttctc tgggatggta tgtttggaat tcctctgatg ccccacctca

3601
ccaacttacc cggacaataa aagcaaggtt gtaagccttt gaacagctgg ctggctatat

3661
atttcccttc tttctttcgc ataatctaat tcagaaaaga atccagctag actggcagtg

3721
ccatgtctgg gtacttgttt cctgcaagtc cttcctcctc cacctcctcc cgccagtcct

3781
ggaatcttcc tgggtggcat gtggcttttc ttttcttttg ctcaccactg ctcccagccc

3841
gccccctttt cccttcgcct gagctccttc ctttgtcagc tggctctttg ctctgcctgt

3901
tttccagaca gcttgggtcc tgttccatcc ggggagaaca gcccatggga tctccccatc

3961
tccatagtat tcccaggatg tcattcttgg caccagctct gccgggctga taggactggg

4021
gggctttttg tagtcccgag cctgaatcca ctcacagaga ggagcagcca catggcttag

4081
ctgccctttg ggctgccgag agcggggctg gagtgaccgg gttggcagga acgagcatac

4141
catcacagtg acccgaacat ctccggcaaa ggccttgggg tgggagcgct atgggaatgc

4201
ctggatgcac ttcggcctac attaagagaa atgtggttat tctctgtttc gggggagaga

4261
caagcggctt gaaacaaagc cctctggatc cttggcccct tccctgcccc ctttcccggt

4321
ctgtccttcc cacatccctc cctccccaaa cagaaagaaa gagagacagg acttctaatt

4381
tggccagcac agacccgaat gtctttatga aacccattta gtgaaagaaa gaggggagaa

4441
atatattctg ggttgatccg aactaaaaaa tgcatggggc tttggagatg gggcgggatt

4501
ttttctttct ttctttctgt ctcttaagag cagaacaaca gtttcgttga tgagttgcaa

4561
atggaaggaa gtggacctct caattagaga ttcccattta agagcctcaa tgtaaacctc

4621
cctgtgacat ccttaaaaga tgctgctaat gtccctggga ccaaaaggta ttaaacagca

4681
agccaccagg cggcttccta ttccttttct ttttctgggg gctttggtcg tctttttcaa

4741
attagctaaa attcattaaa ggacccaaaa ggaaaaattt aaagcagctg aattaaaatg

4801
agtctttccc tgttagcctg acaagaagaa aaaaagaaag gaagaaaggg aaagaaagag

4861
aagaaagaac caattcccct ccactaccac ttcttgggtt ttaatatgaa ttattccata

4921
caagtcccta ggctagagga tctatttaaa gacgcctggc agcatgaagg gagagggtaa

4981
aaatacaacc actcttttgt ccatcaaagg ttttctttgg gaggacatta agagcattcc

5041
tgttttcttg tctgcccctg ccagtggcaa tgttccagct ggtagtatcc actcctcgcc

5101
catcaggtca gcaatcatga acttctgtgt ttaatttcag gagaaaacaa agggtgggaa

5161
atccttccga aacccctatg tgtgtgcagc agggcagggg aggctggaac tggaatcagt

5221
actctcttgg ctgtgcaggt tgcatgctgc aaattcacac acccacacag ttgagttgtt

5281
gaggaagatt gtgccgatgg cattatttct gatgccagct tcccttgcat ctgcaaagct

5341
tttttcttgt gtctctggca gtcatttgct tgtcaccatt catgtgcact gtccccttca

5401
tcagaggttc tcagagcctg atggtcaagg atatgtcact agagtcttac ccccagaccc

5461
attttcaaca gtaagaacgt gaaaccctgg atggggtttg caatctgaag caactacttt

5521
cttgttagga agagtgctga ctcagaaaat tcaaagaatg ggtaacttcc gttggcgaca

5581
tatccccagt gctcataatc aggaattcat ccagttgggg tccatttcac cctcatggca

5641
aaatctggac ataaacattg actagtagct ttaaactggg tataagattt gcaacagata

5701
acatttttgt cttttctttt ttcttttttt tttccacaaa agctaagaat ttttcagaca

5761
atttgctctc ttccaaggcc tggatcaatc ccaacttttt cttttaagcc atgatccaac

5821
caattgcagt atcctttaaa aatgaaaggg caacaggcta agacattcaa gaaagttgat

5881
aagcbgtcag aaaatgctca agggtggcct ttctacagtg ccacaaacca acaacagccc

5941
taaacgtgga gtcctcttcc atcctttcat cagtagggaa taaaaatagg gagagagcag

6001
gtcaggggag aagtaacaaa agagaagtaa gaaggattat ttttgatgtt caaaatctgc

6061
tgctgccctt tcaatatttt caaatatcac aatttcagaa agggaaggat ccctttattt

6121
cacccactct ccctcccagg aaggtgtttg aagttgctgt ctttacctga aaaggaggtc

6181
aactcctcaa gtgaaaaaac atcccctatc ttcaactcga agtaaaatgg aggtacacac

6241
atttgtacct aattatgtgg gtacaaatat aatttgtatc cacaaactat aaaggatgta

6301
aagaatcaaa gaaatccaat ccttaatcaa agtccaattt ttctttaaaa cttgagagga

6361
tattttaggg ctcattgcat tgctgtgatt tcactgcccc ccaccaaatt atgaaaaatt

6421
actccttttc agaatttaaa tttttctttt gagatgtgga atccaaaggc agcagaatag

6481
tattgttaca gggaagctgg cagtcaaaag acatagacat agctgcagca tgcatggttt

6541
aagcaaatca agacaagcag aaaaccacca ccccaacaag ttcagggtta tcagcaatat

6601
agggacacgt atttttatgt gatttttatg agaaccttgc ccctttgaca tatgtctgag

6661
tctaggagca ttccggattg caacgggatt gaattcagta ttcaaatccc accattgggc

6721
agaaaaggca aattgaatgg ggaatggaaa gactgagttg ctcctattgt ttatgcccca

6781
ttcctaacta agggctctac agctgttagg tgagatcact acccaccatt ccaaagtgtt

6841
gttgcjggtg aggaggttca aacgcagctt tggaaacact ttgctgcact ctttgaagaa

6901
aggccaacat gctcatttgg ctctagggta aaagagagcc tgtaccctga gctaacattg

6961
gtcacctctc ctcctgaggc cataccacag ccagcagtac agcagcagaa caagtgttta

7021
gttgtttcag cacaggtatc cccagaacac ctggcacctt ttcttttcca cagggagaat

7081
gtacattcat gcattttggc aagactgagt cctctgagtt gggtgtctcg gaactctcct

7141
attttccttc taaagggtct tatgtaaggt gagcagtaga gbitgtctca ttcctcataa

7201
aaaatcccct tcctgggagg gagtgggtga aatgaaggga tccttccctg actgaaattg

7261
tgctatttga aaaaattgaa agggcagtgg cagattttga acttcaaaat gaatccttcc

7321
tcctcctcct cctcttttgt tacttctccc atgacctgct ctctccctac tttaattccc

7381
cattgaagaa aggatagaag aggactctgt gtttagggct actgttgatt tgtggcacta

7441
tagaaaggcc acccctaagc attttctgac agctcatccc catctcagtc acagctttta

7501
tttgggtagc tggatttaca gaaataatca aatccctaga ggaaaagact tcaacagaaa

7561
agtacctcct gacacttggg taacctgact tggtcatttc caatttatgc aagatttgta

7621
ttctaaaagt caattagtta tgtcaactgt taaaaactca gaatgagtct ttccattctt

7681
cagaatgact cttttctgat tatctgtggg ccatagaagc ccacagatac tcagcacagg

7741
atccaagtgc cataccaagt ggtcaactct tttagacgta agtctcagcc cagggcttct

7801
ggaatgtacc tcccctagca gagaagctct gtagtagata ctttaccaag cacagggcct

7861
cgctcttgac cccaagacta ctgattctac ttgcagagaa gacaactttt ctaatcaatc

7921
tttctcttct atcctgaacc agagtatcag agattgtccc attagggcac gaggatctgt

7981
ggctcaagct cagttaagaa ataagcgtct ttcaaaagaa aggtgcaaga gggtggaact

8041
cagcctatat tgtcattatc aaatgcaaga agtctaatcc tagcatgatt tattaatatt

8101
agcctttctt ctctccccgt ttatgctttg gtgggtactg gacagaaacc ccacaaattt

8161
taagacagtt ttaagagaaa tagtaactgg ttaaatatcc tcactacttc aaattattat

8221
tattattatt gatattactg ttaacttttg tttttttgag acagggtctc actctgatgc

8281
ccaggctgga gtgcagtgat gcgatcacag cccactgtag gctcaaccac ccatgctcag

8341
gtgatcctcc cacctcaacc tcccaagtag ctgggatgac aagcgtgtac caccatgcct

8401
ggctagtatt tttttattat ttttgtagag atgaagtctc cctgbittac ccaggatgat

8461
cttgaactcc tgggcttaag tgatcctccc aacactgcct tctaaagtgc tgggtttaca

8521
ggcatgagcc gctgcacttg gcccacttcc tatgattaac aggatattat taatttagaa

8581
actatttagt acatggcaag cactcagtca aatggttatt aacggcbgtt tttatttcag

8641
gccaccaata tagcttcatc aaggggcaaa tacttatagc ttgggcttca gtgttggatc

8701
agacaccacc ttagaagttt tttgcaatca ttaactcctt aagtaagaag ggaactcttt

8761
ttgtaggatt gctttgggga atatgtagcc ccaaggcagg ggctgtactc tgagaagctt

8821
gggtagagtt ggagactgtt agaaatggat agacacataa aagcatttag accaatctgt

8881
tcattttgca gatgaggaaa ttgagtccta gaaaaggcaa gtgacttgtt caagatcaca

8941
cagccaatga tgggagggta ggactcaggg cttgaggatc agtttcagaa tgcagtgaaa

9001
ttgttatccc atatttcttt caaatcagta tagggacacg gaacactaac aacataggcg

9061
accaatgggt ctagggagga aaagatgaaa gctgtaggta agtgggagtt tggataacaa

9121
tgagatgttt ttctggagtt cctgacaatg cctgaaaaaa aaagtcagga ttttaagctt

9181
cagtcaggct caaggtcgag tcctcccact ccagtccctc ctcagacagt aaaacttttc

9241
aagccaagga catacatata ggtgggggca tttgacagtt ggctcatctc cccaccctcc

9301
aaattattta tatttctagt ccttcagttt agcactccta tttaccccag gattgtaatt

9361
cattgcctct ttccctggcc atattcctcc atcctttttg tttctcccat ctcttttctt

9421
cctccatcac ccccactgct gagcttggct acacttggct agtagtgcag gttgggagaa

9481
cacagagtcc tatcacagac tggaggacta ttatttaatc acaagaatgt tgtctttttt

9541
ctcctaaggt agcactctgg ggacggtcat tgctgtcttt attccctcac ccccccacca

9601
cccctgcact ggattagaca catgaaatgt gcctatctct gagatgaaag gagcaagaac

9661
tgcttcctcc ccactgacct tttgcctgcc catccttgga gatacctgga gttggcaggc

9721
tggaggccta gcagcatttg cagtcagtgc cgctgcctct gggtcagccc aggcttggct

9781
ccttggctgc tactgatgtg ctgccagcta ggaatattaa aaaccattca ttgaacgcac

9841
aggatgcttt ataaaatcca acatgcbgtt tacagtttat aaattaactg ccttgggaag

9901
aggcatttga cttattctcc aaggcatcta gttgactaga tccaattgga atcctttgag

9961
ttcctgggaa ggggctactt aacacttcac actttctaaa ttagacctag agtttcttgc

10021
ttttctgatc ctagtactgt atgaagtttt atctagggtt atctagcaag ctttcttcca

10081
cttataaatc tttgatgttt ttgcaatttc tttgatagag gctttatgtt ctactatctt

10141
cactttattt atgcttcata ccataatttt ttaaaaaatt acaataaata tcaagtaatt

10201
ctggctgata tactgactcc attccaaggt cattatattt tatttgctta acttggtctt

10261
cttagaaatg atgcaatgaa tactggatac aaattagatg ttcagagagt ttatcaatgt

10321
gtctaaaaac catccaggaa aacaacaggc caagactctg cctgcagagt cagtgagcta

10381
gaagagggat cgaggatagg aactatattt ttcccctgac cctatctctt atctgctaga

10441
gcaaaaggag acacacagta ggtgctcaat aaatacatgt taaaaaatat ttgttgaaag

10501
aagccacaga agggaatatc agtatacatt agtattgaaa acagcctagg gggaaatatg

10561
gatactgaag caccaccctc ctgtgcctgg caagcaaggc aagaataagg ccattcttgg

10621
cacataccac ttagcctgtt gctgagataa cttgcgtgaa accagcactt taccctctgc

10681
cagccagaag gtcagcccaa gagtgagctg atctgtgggc acaacaccat ctctcaccca

10741
ggaggcbjgg cccgctgtaa gctctgctat attatttccc tgaggatgac aggtggggaa

10801
atctgggcac cagttgttct tttccactgg tatcatttgg aaggtagctc caaagtcggg

10861
cacgccagcc tacgtgcctc tcctgccggc agaggctcca cattggagct attagaatgt

10921
gggctctgta cgtcjgccaa gtccatgtct cagagactgt atccagagca tagcgtggcc

10981
acagggctac tgagttcagc aagagagtca ttctcttgtt caatccatta ttgcctgggc

11041
caaggttcta agtcttcgta ggcagcattt gattttatga cacgtcttaa aaaattaagg

11101
caaactggaa ttaatttagt tttgagaaaa caacagaagc tgctacaagg cagagataat

11161
tctaggctgc cagaaagtgg tgatctcagt ggtgtacatt ttcttaattc ctgattttcc

11221
tctttgtgag gtcttcctcc cactcccata ctttgcacat tctcacctat gcacaccctg

11281
agcaacacaa tgttgacaac ttgacttagc attgctcttt tcttaagctt tgttttcatt

11341
tcttcttcaa tacaacagtg ttggttcatt caatttgaac actcaaggca aaaaaaaaaa

11401
aaaaaatccc aggttatgtt ttcagaatct tacctttttg tttttgtttt gagggttctg

11461
tgagttttgt ggcatattta cattgttgct tacattctta tttcagaatt taagataaaa

11521
actgggcaac aactctcacg ttttctgagt gtgttgaaat gaaaaatctg tttcttagaa

11581
ttaatggtaa agcaacattt cctgtcaatc tttcattctt taatattact tctgggttca

11641
gctcaccatc tctaaagaga aagccagatg atcaagttac attgtatgtg acattaacta

11701
tctctttatc tgtgtaaatg tcataatatc tgcttgcaaa gtgttttatt catttttagg

11761
aaaaaatttt aaactgtgct tgcaattcag gatggtgcta ctaggtggca gtaatgtaca

11821
agaactatgt ggtcgccctg gaagagtatt tgactaagag actagcatgc cttcccgtaa

11881
ttataagaaa taaaaatata atatttttaa aatactcaaa ctggcacaaa cagtaaacat

11941
ccattaactt agttaccata tttaagctga gcttttaaaa gagaaagcct tattttttaa

12001
tgaaatttta aataaagtat acattcacaa gctcaaaaat ctaaaaatac gaaaagatat

12061
atagtgaaaa gtctttctct catgcctgtc cctcaactac cacaggtaac taattttgtt

12121
agtttcttgg gtatcctttc agagctttgc tatacaaata tgtgttttta tctctctcca

12181
ttttaactca aatcaataca tagagtttct gcatccttcc atatatagtt ggttagtata

12241
ttgttgtgtg aacattttag aatataatta accagtcccc tattaatgga tatttcatgc

12301
tgtttccaat tttatgctat ttcagccatg tgctcatgtg atttcacatg taggataatt

12361
cacagaagtg gaattgctgg gtctaaatta tatacatttg catttttaaa aggtattgcc

12421
agattggcct ctacagagtt tggaccaatt tatactgaac tttctccaaa atggacttgt

12481
tttcccacag ccttgccaat agggtgcatg atcagacttc ggaatctttg taaatctgat

12541
tggttgaaca atgtatttca aagtacttta attttcattc tcttaaatga gacttttatt

12601
ctcttaaatt ctcttctatc tttaagggcc ctttatattt cctttttctg tggagaaagt

12661
ggaaatgcca ataaatacaa cgatgcatac acatgtatag ggttttgtta ttgatgtagc

12721
ttgtttttgc catcatgctg tacatgatgt tctttaattt gctttgctca tttaaccata

12781
cctcctggcc atggctctga agagaagttg ctggcagtgc agaagaaggg ccaggactgg

12841
aatgtctgct tctctcttca tccttttgcc attgactcct gggggaaata tctgtagacc

12901
gaagcagtga aatctaatca attctctttc tgacactaat taaggcttca aagagacaga

12961
taaccacttg ggataattta gtcacagtga aacttgggaa atggtcagta atatttcatc

13021
ctctgaaagt ggaccccaag aaagttctgg ctctttgagt tgttgtcttg gtaattttca

13081
gggtaacgtg tataggaaaa cccagattat gcagatgaaa agaaaacaaa catgctcttc

13141
tgcatccttt gcagatttga aactttgggc acaggtttga tttatttcaa tgagatgttg

13201
ctattagcat gaacataaag tggtgcaaag ttgtgctgga atatggtctc gtcaactttg

13261
ggctcactgt ctgcatatgg agatgatagt aactgaatcc atagttatca agtggtggca

13321
ttttagaaca caaagggaca gcagatgcca tctctgtcaa ctccttccct ctacagatga

13381
ggaaacttgg gctagaggag gttgaatgac ttgtgtaagg cttccccagc taattaatgg

13441
cagtgccagg actcaagtcc aggtgggttc cctcattact ggtccttgcc cttcctgcaa

13501
tttataggac ttccctgagg cacatgtgct gaggctttgc tattgccagg gattctgtgc

13561
tctgaaacag ccctatctca cacacccctt tccacttagg atcccctacc tcacacttcc

13621
aagacagcta attgaggcta aatgggtctg atgccattct attagtgcaa aataaattgg

13681
cttatgccaa cttgaactcc taatcttgat tttatcaaca ctttgccctg tttattcaga

13741
ctgttcatga gtaggaagtt aaggaaaatg ttgcctatga acaaaatgat caaactttta

13801
tctgaaatac ctttgaaagt tttcccgaag ctttaattat catgttcctt ttgttttgga

13861
tgtaatagca ggccctccca attttcctaa atgtttgaaa atatttttga tactttctgt

13921
cttctgttgt ggttaaaaaa aagaaggcac cagtgttggc tatgcctggg gagttagtga

13981
ggtaatctgg agagatctct ggaccccagt cctttgtcca agaggtatgg tcaaaagaac

14041
aaagcaaatt tcagaaaaac cggtataata tgatcctatt ttaatggtaa gtctgttcca

14101
acaactgctt tctttttcga attacaccat gtgcccaggc tacaaaggct ctgcagaaat

14161
gtgactctgt tggcaaatac gcgtgtgata ccttaaccat gctggaggcc agttagcata

14221
atgbitattt cagatgcagt ttgtcatcag tgcbgggtgc tatggggctt aaaacaaaaa

14281
caggatgagc ctagagcaca gaagtggaaa attaggtggg tgggtgagta tggacttgga

14341
aatggaaaat gtgcttccct gtgggacatg gcttgtgttc attagtgctg acctgcctcc

14401
tctctagccc tgtaagctga cgctgacacc aaagcttgct gagaaactga atagaccctc

14461
ccgccccgac caaccaagga caaagatgag accacccaat tcggttacgt tgttgccaga

14521
acaacatgtt taatctttaa catgggttca aactattctt ggccctagga acatggactt

14581
cagcaattaa agtcaacatg tgcttccatt aaaccattgt gtccacctcc aaatggttat

14641
aaatatgtag cataagctat gggagttggg gtggaatgga tgacagcctt tgctaatgac

14701
gctctagaaa ccaatattct cctctcaaaa taacatggaa aaattctact taatacctcc

14761
tgggttccat tagtggttct gggtaaataa ttctggggaa agtaatttct gttttcattc

14821
cagctgtgca gcagatactg tgatgatgga ttgcaagtgc aaagagtaag acaaaactcc

14881
agcacataaa ggacaatgac aaccagaaag cttcagcccg atcctgccct ttccttgaac

14941
gggactggat cctaggaggt gaagccattt ccaatttttt gtcctctgcc tccctctgct

15001
gttcttctag agaagttttt ccttacaaca atgagaaaac atgtactagc tgcatccttt

15061
tctatgctct ccctgcbggt gataatggga gatacagaca gtaaaacgga cagctcattc

15121
ataatggact cggaccctcg acgctgcatg aggcaccact atgtggattc tatcagtcac

15181
ccattgtaca agtgtagctc aaaggtaaga ccaaggtctc tgtgaggaga gcatttccct

15241
cagaaacagg caagaagcca tatttctttg tcaggggatg gagaactaag atcatagccc

15301
aaacttaagt gatgtggctg gcccacaggg cttgtgggag aatgaggctt ttagaatttc

15361
cccccgtgct ttgcactgtt atcagtaaaa gtgcctaatc aatcatgtgc acacccatcc

15421
agtgggacag gtgtcctttg tccctggctg tgatgtttat gagtggtagt gtgcttttcc

15481
aaaaaagaaa aatggagttt acaagtcatc ataactctct agctccatca tcaataaaga

15541
ggaagagaat gcaaagaatg cgattgagca gtggaacata cttcttggag ggctctttaa

15601
agagattctt ggtgaaataa ctggctttgt ggtctgagcc tttcttcagg tgctacattt

15661
ctgttcaaat gatttcaaaa gataagatgg caatatgatc atttatcatt tttacattgc

15721
ttatccaaat cgttctcatt tggaaaagga tgcabitttc ttgcagaggc agtccgtgcc

15781
tcagtggtgt gcaagggaat atcatgctta aaaggccacc aagagtggcc agctacatgg

15841
accacccaga agggaggcac attgtagggt ggaacatacg agatctcacg actgtcactg

15901
cccctaaaca ggcacaatga atgaaatttg tccacacttg gtaaataata atttgtttag

15961
cccaacctca gagattttta catttagttt tgagatgaaa atcacttaaa cattctcgta

16021
tggcaagtaa tttttgaaat taccagtata attaagaatt ttttatagta tcaatcacca

16081
gaattaagac catataagcc aatccctcca ctctccattc aaaaacatta tgacttttgt

16141
atgccttgaa aatttccatt aatttctctg attatagctc agtgatgatg attcatttta

16201
gtttaggagg atcagaattc gagttaaatc attttaacca ttatattaat aagatctatg

16261
actgbjggaa aaaatagaga ttttccactt aataaaaact ttctggctct tatttgtgct

16321
tgtagaacca aaaaaaaatg gagtaaatag atgaacataa atttttgcag ggccacaatt

16381
ccttcttagg aaagggaaac taaaacaaat tgagaaaaaa catgagaagt gcttttacaa

16441
gtgtgattgc tcagaaattg tgggcccatg taaggttgac tgcagcaatt attagtttct

16501
ccttccctcc cccttcagaa acagacagca tgaatattta gtgattttat tccatggata

16561
atttctttcc gtattgagtt gtcctccata atcgtgattc ttttttaaaa aaaggaatta

16621
aaattatttc aaagaaagtg tcactatgat gatagaaagg aacaaagaaa taggagcatc

16681
tataaaaact agaaaacaat ctggaaagac tggacaaaat gatggaggag tactttggca

16741
acaatcacat taatctagcg aaggtcaaag aagagacatc atgaactcaa accgaagaaa

16801
ttcacatgtg aattctgagc atgagtctta gaaacagact ttagtgtact gttattcacc

16861
tttgtttctt ccagaaagcc atggcaaata acagcgcaaa attgtgatag caggagaaat

16921
gtttgtaatt tcatgggaac aatctgtttt caaacatccc aaactatccc aaatatagca

16981
atagttttat gtaaatggtg cttgcaatta taaacctttc ttccctggcc ataaaatatg

17041
cctggcaaaa tctcaactac ccagaccttt tctaggttag atttttctct atgtatccag

17101
gagcaaaact gttttcattt ggaaatgttc tataattctt aactcttaca ttctcgggct

17161
gatcttttct ctaatgggtc tcacttaatg aaattgtttg cctttagaga cttggataaa

17221
acatttagcc tatgtctaga aaagaggcaa caacaatcta ccctagcttc tttttacaaa

17281
gaaaagactg ggatagattt ttttgtctct ataaaaatta tcccttgaca tcatgttcaa

17341
gggtcattat ttattaaaca tgtgcctact gtttgcctgc caattgttaa tgctttctga

17401
ctcacattta tccattatct ggccttgtaa aggcaagaaa gggagaatgt gacccaggct

17461
cagggaaggg agtgtacctg cttgaacacc taatatatgt gtcaggcacc tcatattgta

17521
tattataatc attgccaaga aacctgtgat ggcaggcatt attattccca ttatcctggt

17581
aaggaaaact gaagcccaaa ataattagat tgcttgatat catatagcca gggagtggca

17641
atgtctgcct tacagcattc atcttcccac tacttggatc ttcatattgg aggaacacaa

17701
gtagaatgta ggagccatca catagaagtt caggctctgc ttctgatctg ctggcagtaa

17761
taatttatac tcagcaatgt ttctagaaaa aataaataat agtgaaagcc tttctgggag

17821
ctttcaatga gactgttcat cccagccctg aacttgcagc tggccagtcc taggtccctg

17881
ctgcccatct cctagcaatt ccggaaagga ctgagaggga gtcaggcaga aaagactggc

17941
cacagtggcc caccaaagag gacagtgtgg ccacagatta ggatgtgcct gatagtttta

18001
agtggtggca cctcctgggt ttgggtacaa aagatcctgg gagtagcagg ttcatttata

18061
atcttcatgg aagactaagt ttctctaaaa tttggagtaa aggctgtaga gcaaacaggc

18121
aaaagaccag ttgatagtgg aaacagactg cctggtggaa tctctatgag aactgaggca

18181
tgccaggctt tgaagtgaga gagacctggt ttccaattcc agctccatgg cttgccgaat

18241
gagtgacttt gaggaagttc agtaacttcc ttctttgtgc ctcagtttct tcccatgcaa

18301
aatagagctg tctacctgag ggtatgggta tgggtgttgg tgatttgtaa agcatccagc

18361
ggtgtccagc acataatagc catttaatag aagatattat gatcttgatg ataaagttat

18421
aaactaagca ggtgtttaga ctcaattttc tatttcagtc acaactgaga tctcaataac

18481
tgctgggatc tcctatagcc ttaaaagatt aggaaaatga accttattgt agttcttgtt

18541
aagcacaggg tggggcagaa gagcaaagta aatgtaagcc actgtgctgg gtgctaacag

18601
ggaggataaa agtaaaagag aaacagcccc gatatctgtc taaccttcct tcccagatga

18661
gtggaggaag gaggggctgg agggggatga gttttggact tgggccaggg aggggatttc

18721
aggaatggag ggtgggaaag caaactggca gggaagacct ggaaagtctc agttgggtga

18781
ggagtggggg atgctggccc caggccaggg catggaacca gggcatgact atctgaaccg

18841
gtaagggcca caggagcagg tggggaactg gaagagcaac aacaaaggat aaggaggaag

18901
aggtttggga gacaaaacct aggaaaagag gacctggtat gctaagggct gagtcctaac

18961
agcttcctaa caggaccccc aagccatctt ctactgctac ccaccaagct catggtgtga

19021
taggagaaat ggagggagtc aggaaaattg tgtttataat acaatagact tcttgagaga

19081
tataatttga tttttttaaa aggaacaaat ttatactgag tgcctaccat gtccaggtgc

19141
tgtggaaggt gctggagact ctaaagtgga aagaaagaaa aaagagacaa tttttttgcc

19201
ttcatgatgc ttacaagaaa atggggagag agggaggagg ggtgttctgt gcacaaagat

19261
cagtttgtat ctgtttgatt catgaccgga gtgaagggac cagtttctag ttggagtgag

19321
ctgagttccc atccaccctt tcaaagcccc caccatctct ctgctgcttt gttccctggt

19381
tgcaattttc ttggtgccct cagcctagca cagatctttt ggaggttgac ctgggtccct

19441
gaagatgagc ggagttatga ggctgcccgt ggggaaagaa tgggagaaga agcatgggtg

19501
aatcttgttc ctgaggttat agagggtgtt tcaagaggtg ccatggaaat aagggtgcat

19561
agtgttcact gctgcgaaaa aggcaaaata cttttccact cbitcggagt aaaatcgcaa

19621
aaatgctctt ctagggtggg acaggtgggt ctttattctg atgctaatgg tgacatctgg

19681
tcagtcaagg ctcttggaag attcagctct gcataagctt ggggatggtg aagctaatgt

19741
cccaagaagc ccacaagaaa aagttagact tgtatgtcta tggatatggt caggggtttc

19801
tgaggcaaat caatgtagat aaggaagtct gtgagttggc atatgcttga ggaaaacatg

19861
gtatcaggag gcaggtatta tactggttta ggtcagggct ttggtttcag atagaccttg

19921
gtttgattcc agctctgcat tttaccacct atgtgagttt gggcaagtta ctggaactct

19981
ctaaagcttg agtttcctta tctgtcctaa tagtgtagat cataacagta ctttcttgta

20041
gggttgttgt aaggatgaaa taactcacat tgcaagtgct caataaatgt tcttattagc

20101
gaaatgatgg ttatctagtg attcatctag agcacagccc tcaaacttga atgggtccag

20161
agacctgcta ctcaaagtgt gggcaccagc ccagtaggac tgacatcaac tggaatctga

20221
tgggaaatgc agaatctcag gctctaggcc agaactactc aatcagaact tgccttttaa

20281
caagatccta gatgattcac acgcacattc cagtctgaga agctctgatc cggaagagat

20341
caggagatgt tcaagtgctg aaacacaagt aaggcatggc agaagctaaa atgtgaagta

20401
ttgagagtaa accaggagag cagatggtta ttccttccat cccttaagga tcttatcttt

20461
caaacttctg ctttaccact tcaacacaca aaacagagat agatttcctt ctaggagtgt

20521
gtgtgtgtgt gtgtgtgtgt gtgtgtgttg agaacatcaa tggttcaata attgcttcat

20581
agtcttttct tccaggaaag agcatttgaa tttggctaca gagaatagat aggtgggatt

20641
ttattaggca gagcaaggtg gaaaggacat atttgggaga cagaagacat aagcaaaggc

20701
aagaggcagg agaattcagg gcactttctt ggactcctaa gtagttaagt ttgactggag

20761
tagggagtgg gtagtagagt gatgagaata gttgtaagta agactggaaa tacatgtgaa

20821
acctgggtca tgaagggcct tgactcctct tcaagatttt ggattttatt ctgaactact

20881
gaaggcattt attgtacatg tctgtgcatt cttcttgcac aaacagtcca gctcccaagg

20941
aagaggggcc cagcccattg gaggtggccc cacgtccttc agtgcctgga gttcttgtcc

21001
ttcagagtgg gcbgggggtg gagctggaca tcctgaaaac ttttagtgag attgcaatca

21061
gatgagctca tttacaaatg gccctacgct gttgacttgg tcattttatg gacagtgcta

21121
atggcccagt cagttaggcc tacgtttggt tcacctgtgt atacatcact tggatattat

21181
gtcccatatc attgttggcc cttctgagtt aagttcgttg gcacagattt actttgtcca

21241
cccagactga aactgcacct ctgaagactc catcacggaa ggtgactctg tgaataactg

21301
cttagtcaac ctaatagatg atctagatga gagattagca aatttaacac tactccaagg

21361
tgaggtatca agcagctctt cccacataca gggagatggg gggagaacag actaaggaag

21421
atcttggact ctctctctca ttagagaaat gggggtggga attagggact agcctgtgta

21481
ctactgacct atggcatagt ctctcaaaac ccatttcaga gccaggcaca gtggtacatg

21541
cctgtagtcc tggctacaca ggaggctgag gcaggaggat cccttgagct caggagttta

21601
aggctgtagt gtgctatgat catgcctgtg aataaccact gcactgcagc ctggacaaca

21661
tagcaagact ctgtctctaa aaacaaaaca aaacaaacaa acaatcattt ctgatagttt

21721
actttgcctg tcaaaatgaa gagcaggtag gatagaatca aaagctttaa aaaaatcaaa

21781
acagcttaca gctgctattt tctctctgcc tctgcgatca ttcagagaaa ataaattcac

21841
tggtctagtc caacttattc ttccctaagc cctgctgttt tttttttcta gtatttcata

21901
ttgccttggt ggttgctaag tgattgttgg atttagcccc agtatattct cagataacta

21961
tgccaataat ctataattac cagaattcat cttttctccc ttttggaaag atggactggc

22021
tatttttttc ttgtaaacct tgggtgttta attctgccct acaggatgat gtcagagata

22081
atagctggtg agtctttaat aataactgcg aattcctaca atattgtaag gtaaacgtca

22141
aaaggtttca tgcatatata tgtatctttt aatctttcat ttgaacagtt tcacttttta

22201
tgatcttgct gttggttctg gaattatagg acaaattttt cttttctttt cttttctttt

22261
tgagacaggg ccttgctctg tcactcatgc tggagtacag tggcttgatc atagcttcct

22321
gcagcctcta attcctgggt tcaagtgatc ctcctgcctc agctgccaaa gtagctggga

22381
ctacaggtgc acatcaccac gcctggttaa ctttttattt ttttttttag agacacggtc

22441
atgctatgtt gcccaggctg gtctcaaact cctggggtca agtgatcctc ctgcctcaga

22501
ctccaaagtg ttgggattat aggcatgaga caatacacct ggcccagggg atttttttct

22561
ccatcactta acatgaaatt caccaagcaa aacctcttac ataaccatgg gaccaataat

22621
ctcagattct ccattcccct ccccaccttg atattaggat tatgcagctt aatgagtcaa

22681
gctgtcccac cctacccacc tattactccc actcccagga taccaggagt tttgtatggg

22741
atacataaat gatccttttt tccattccgt taagctgtat gcaaattgtg tgtgtgctta

22801
tgtacatttt tctggggata actttggtag ttttcatcag attcttaaag gtgtctgttt

22861
gctaaagcca gattaagagc tactataaag aacacatagc ctccgttatt ccagcccaat

22921
ctttggaaat agagattatc agaatgggta catcctaata tttgccgcaa atgactctga

22981
agatgcggat gcaattacat aaatcccagg ctccttcaac atataaaccc agaagtgtga

23041
tttcagggcc ccagacatgc cctgtctcta cttcattctc ttgtcccaaa ttgcagcacc

23101
cagaatattt cttcctaagc attactcagg ctatcctatt ttcttattca gaaactatat

23161
tcctgttctt tagctatttc ctgcacaaat caatttcttt tttttttttt tttttttggt

23221
agtcatttta atttacttct tggtttcaat ttggattgac tttctgcatt ttgctactgg

23281
tagaattgca atgcattggg ccagtggtag accactacct gtcaggagaa atttcttttg

23341
ttctttggtt tttactcgca catcacagtg atgggcgtca ttcagtggtt ctaaaccctc

23401
agtacactta gaaatcacct aagaagcttt gaaaaccatg aaagcctggt ccctatctcc

23461
aaggatttta attcaatcga tctgaatgag gcctgggtgt tgacttaaaa aaaatgcaac

23521
atgcattgag ccactggtct aatctagcag gaattggcaa cgagtgtgag ggtctttcaa

23581
aagatgctgt tttacctggc taaggttgtg gcatgcccac agagtaacca cctccttttc

23641
tttccccaga tggtgctcct ggccaggtgc gaggggcact gcagccaggc gtcacgctcc

23701
gagcctttgg tgtcgttcag cactgtcctc aagcaaccct tccgttcctc ctgtcactgc

23761
tgccggcccc agacttccaa gctgaaggca ctgcggctgc gatgctcagg gggcatgcga

23821
ctcactgcca cctaccggta catcctctcc tgtcactgcg aggaatgcaa ttcctgaggc

23881
ccgctgctgt gtgtggcttc tggatgggac aactgtagag gcagttcgac cagccaggga

23941
aagactggca agaaaagagt taaggcaaaa aaggatgcaa caattctccc gggactctgc

24001
atattctagt aataaagact ctacatgctt gttgacagag agagatactc tgggaacttc

24061
tttgcagttc ccatctcctt tctctggtac aatttctttt ggttcatttt cagattcagg

24121
cattttcccc cttggctctc aatgctgttt gggtttccaa caattcagca ttagtgggaa

24181
aaagtgggcc ctcatacaca agcgtgtcag gctgtcagtg tttggtgcac gctggggaag

24241
aatttacttt ggaaagtaga aaagcccagc ttttcctggg acatcttctg ttattgttga

24301
tgtttttttt taccttgtca ttttggtcta aggttgccat tgctgctaaa ggttaccgat

24361
ttcaaagtcc agataccaag catgtggata tgtttagcta cgtttactca cagccagcga

24421
actgacatta aaataactaa caaacagatt cttttatgtg atgctggaac tcttgacagc

24481
tataattatt attcagaaat gactttttga aagtaaaagc agcataaaga atttgtcaca

24541
ggaaggctgt ctcagataaa ttatggtaaa attttgtaag ggagcagact tttaaagact

24601
tgcacaaata cggatcctgc actgactctg gaaaaggcat atatgtacta gtggcatgga

24661
gaatgcacca tactcatgca tgcaaattag acaaccaagt atgaatctat ttgtgggtgt

24721
gctatagctt tagccgtgtc acgggcatca ttctctaata tccacttgtc catgtgaaac

24781
atgttgccaa aatggtggcc tggcttgtct tctgaacgtt tggttcaaat gtgttttggt

24841
cctggaggct caaattttga gttattccca cgttttgaaa taaaaagagt atattcaaaa

Mouse Mature NDP Protein (NCBI Accession No. NP_035013.1)

(SEQ ID NO: 23)

KTDSSFLMDSQRCMRHHYVDSISHPLYKCSSKMVLLARCEGHCSQASRSEPLVSFSTVLKQPERSSCHCCR

PQTSKLKALRLRCSGGMRLTATYRYILSCHCEECSS

Mouse Mature NDP cDNA

(SEQ ID NO: 24)

aaaacagacagttcatttctgatggactctcaacgctgcatgagacaccattatgtcgattctatcagtca

cccactgtacaaatgtagctcaaagatggtgctcctggccagatgtgaggggcactgcagccaggcatcac

gctctgagcccttggtgtccttcagcactgtcctcaagcaacctttccgttcctcctgtcactgctgccga

ccccagacttccaagctgaaggctctgcgtctgcgctgctcagggggcatgcgacttactgccacttaccg

gtacatcctctcctgtcactgtgaggaatgcagctcc

Rhesus Monkey Mature NDP Protein (NCBI Accession No. NP_001253901.1)

(SEQ ID NO: 25)

MRKHVLAASFSMLSLLVIMGDTDSKTDSSFIMDSDPRRCMRHHYVDSISHPLYKCSSKMVLLARCEGHCSQ

ASRSEPLVSFSTVLKQPFRSSCHCCRPQTSKLKALRLRCSGGMRLTATYRYILSCHCEECNS

Rat Mature NDP Protein (NCBI Accession No. NP_001102284.1)

(SEQ ID NO: 26)

KTDSSFLMDSQRCMRHHYVDSISHPLYKCSSKMVLLARCEGHCSQASRSEPLVSFSTVLKQPFRSSCHCCR

PQTSKLKALRLRCSGGMRLTATYRYILSCHCEECSS

Chimpanzee NDP Protein (NCBI Accession No. XP_016799622.1)

(SEQ ID NO: 27)

KTDSSFVMDSDPRRCMRHHYVDSISHPLYKCSSKMVLLARCEGHCSQASRSEPLVSFSTVLKQPFRSSCHC

CRPQTSKLKALRLRCSGGMRLTATYRYILSCHCEECNS

Trio Rho Guanine Nucleotide Exchange Factor (TRIO) and F-Actin Binding Protein (TRIOBP)

The TRIOBP gene encodes “trio Rho guanine nucleotide exchange factor (TRIO) and F-actin binding protein” (TRIOBP), a protein that is expressed along the length of the stereocilia actin filaments and in the stereocilia rootlets of the inner hair cell. TRIOBP is important for the stability and rigidity of the stereocilia of specialized hair cells in the inner ear (see, e.g., Kitajiri et al. (2010) Cell 141: 786-798; and Zhao et al. (2015) Curr. Opin. Neurobiol. 34: 172-179).

Stereocilia, which are about 10-50 μm in length, are important for hearing and balance. Stereocilia play a mechanosensing role in hearing. By bending in response to sound, they form a structure for mechanoreception of sound stimulation.

The human TRIOBP gene is located on chromosome 22q13.1. It contains 24 exons encompassing ˜80 kilobases (kb) (Hirosawa et al. (2001) DNA Res 8:1-9; NCBI Accession No. NG_012857.1). To date, there are three known families of TRIOBP splice isoforms: TRIOBP-5, TRIOBP-4 and TRIOBP-1 (see, e.g., Kitajiri et al. (2010) Cell 141: 786-798). While TRIOBP-1 is ubiquitously expressed, TRIOBP-5 and TRIOBP-4 are expressed predominantly in the inner ear and in the eye. TRIOBP-5 gene (NCBI Accession No. NM_001039141), the longest isoform, contains 24 exons, and the translation start site for the TRIOBP-5 isoform is found in exon 3. The TRIOBP-5 protein has a molecular mass of ˜218 kDa. The TRIOBP-4 is gene encoded by exons 1-6 and is expressed from the same promoter as TRIOBP-5. The TRIOBP-4 protein has a molecular mass of ˜107 kDa. TRIOBP-1 (NCB1 Accession No. NM-007032) is encoded by exons 11a-24, has a molecular mass of ˜72 kDa, and is translated from a start site in exon 11a (see, e.g., Siepel et al. (2001) J. Cell. Sci. 114: 389-399).

Various mutations in the TRIOBP genes have been associated with non-syndromic hearing loss (e.g., profound, prelingual deadness DFNB28 (MIM #609761) (see, e.g., Riazuddin et al. (2006) Am J Hum Genet 78: 137-143) and age-related hearing impairment (see, e.g., Hoffmann et al. (2016) PLoS Genet 12(10): e1006371)). DFNB28-causing mutations have been predominantly found in exon 6 of TRIOBP, an exon that is present in both TRIOBP-4 mRNA and TRIOBP-5 mRNA. DFNB28-deafness can be modeled by generating TRIOBP-4/5 deficient mice, in which mouse exon 8, the ortholog of exon 6 of human TRIOBP-4 and TRIOBP-5, is mutated/deleted (see, e.g., Kitajiri et al. (2010) Cell 141: 786-798). Nonsense mutation (c.5014G>T (p.Gly1672*) in exon 9 of TRIOBP-5) and frameshift mutations (c.2653del (p.Arg885Alafs*120), c.3460 3461del (p.Leu1154Alafs*29), and c.3232dup (p.Arg1078Profs*6) in exon 6)) were found in Dutch families with congenital and moderate hearing impairment (see, e.g., Wesdorp et al. (2017) Hearing Research 347: 56-62). The nonsense mutation found in exon 9 was the first disease-associated mutation that was present only in TRIOBP-5.

Additional exemplary mutations in a TRIOBP gene that have been detected in subjects having hearing loss and methods of sequencing a nucleic acid encoding TRIOBP are described in, e.g., Shahin et al. (2006) Am J Hum Genet 78:144-152; Diaz-Horta et al. (2012) PLoS One 7: e50628; Gu et al. (2005) Clin. Genet. 87: 588-593; and Table 1 in Wesdorp et al. (2017) Hearing Research 347: 56-62. Methods of detecting mutations in a gene are well-known in the art. Non-limiting examples of such techniques include: real-time polymerase chain reaction (RT-PCR), PCR, sequencing, Southern blotting, and Northern blotting.

An exemplary human wildtype TRIOBP protein is or includes the sequence of SEQ ID NO: 28, SEQ ID NO: 30, or SEQ ID NO: 31, SEQ ID NO: 32. Non-limiting examples of nucleotide sequences encoding a wildtype TRIOBP protein are or include SEQ ID NO: 29, and SEQ ID NO: 33.

In some embodiments of any of the compositions described herein, the TRIOBP protein comprises a sequence that is at least 75% (e.g., at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%) identical to SEQ ID NO: 28.

Human Full-length Wildtype TRIOBP Protein Isoform5

(SEQ ID NO: 28)

MEEVPGDALCEHFEANILTQNRCQNCFHPEEAHGARYQELRSPSGAEVPYCDLPRCPPAPEDPLSASTSGC

QSVVDPGLRPGPKRGPSPSAGLPEEGPTAAPRSRSRELEAVPYLEGLTTSLCGSCNEDPGSDPTSSPDSAT

PDDTSNSSSVDWDTVERQEEEAPSWDELAVMIPRRPREGPRADSSQRAPSLLTRSPVGGDAAGQKKEDTGG

GGRSAGQHWARLRGESGLSLERHRSTLTQASSMTPHSGPRSTTSQASPAQRDTAQAASTREIPRASSPHRI

TQRDTSRASSTQQEISRASSTQQETSRASSTQEDTPRASSTQEDTPRASSTQWNTPRASSPSRSTQLDNPR

TSSTQQDNPQTSFPTCTPQRENPRTPCVQQDDPRASSPNRTTQRENSRTSCAQRDNPKASRTSSPNRATRD

NPRTSCAQRDNPRASSPSRATRDNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSPSRATR

DNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSPNRAARDNPTTSCAQRDNPRASRTSSPN

RATRDNPRTSCAQRDNPRASSPNRATRDNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSP

NRTTQQDSPRTSCARRDDPRASSPNRTIQQENPRTSCALRDNPRASSPSRTIQQENPRTSCAQADDPRASS

PNRTTQQENPRTSCARRDNPRASSRNRTIQRDNPRTSCAQRDNPRASSPNRTIQQENLRTSCTRQDNPRTS

SPNRATRDNPRTSCAQRDNLRASSPIRATQQDNPRTCIQQNIPRSSSTQQDNPKTSCTKRDNLRPTCTQAD

RTQSFSFQRDNPGTSSSQCCTQKENLRPSSPHRSTQWNNPRNSSPHRTNKDIPWASFPLAPTQSDGPRTSS

PSRSKQSEVPWASIALRPTQGDRPQTSSPSRPAQHDPPQSSFGPTQYNLPSRATSSSHNPGHQSTSRTSSP

VYPAAYGAPLTSPEPSQPPCAVCIGHRDAPRASSPPRYLQHDPFPFFPEPRAPESEPPHHEPPYIPPAVCI

GHRDAPRASSPPRHTQFDPFPFLPDTSDAEHQCQSPQHEPLQLPAPVCIGYRDAPRASSPPRQAPEPSLLF

QDLPRASTESLVPSMDSLHECPHIPTPVCIGHRDAPSFSSPPRQAPEPSLFFQDPPGTSMESLAPSTDSLH

GSPVLIPQVCIGHRDAPRASSPPRHPPSDLAFLAPSPSPGSSGGSRGSAPPGETRHNLEREEYTVLADLPP

PRRLAQRQPGPQAQCSSGGRTHSPGRAEVERLFGQERRKSEAAGAFQAQDEGRSQQPSQGQSQLLARQSSP

APSRQVTMLPAKQAELTRRSQAEPPHPWSPEKRPEGDRQLQGSPLPPRTSARTPERELRTQAPLESGQAGP

RQPLGVWQSQEEPPGSQGPHRHLERSWSSQEGGLGPGGWWGCGEPSLGAAKAPEGAWGGTSREYKESWGQP

EAWEEKPTHELPRELGKRSPLTSPPENWGGPAESSQSWHSGTPTAVGWGAEGACPYPRGSERRPELDWRDL

LGLLRAPGEGVWARVPSLDWEGLLELLQARLPRKDPAGHRDDLARALGPELGPPGTNDVPEQESHSQPEGW

AEATPVNGHSPALQSQSPVQLPSPACTSTQWPKIKVTRGPATATLAGLEQTGPLGSRSTAKGPSLPELQFQ

PEEPEESEPSRGQDPLTDQKQADSADKRPAEGKAGSPLKGRLVTSWRMPGDRPTLFNPFLLSLGVLAWARP

DLLNFKKGWMSILDEPGEPPSPSLTTTSTSQWKKHWFVLTDSSLKYYRDSTAEEADELDGEIDLRSCTDVT

EYAVQRNYGFQIHTKDAVYTLSAMTSGIRRNWIEALRKTVRPTSAPDVTKLSDSNKENALHSYSTQKGPLK

AGEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRARTPARTPDRLAKQEELERDLAQRSEERRK

WFEATDSRTPEVPAGEGPRRGLGAPLTEDQQNRLSEEIEKKWQELEKLPLRENKRVPLTALLNQSRGERRG

PPSDGHEALEKEVQALRAQLEAWRLQGEAPQSALRSQEDGHIPPGYISQEACERSLAEMESSHQQVMEELQ

RHHERELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRELSKTRSLQQGPDGLRKQHQSDVEALKRE

LQVLSEQYSQKCLEIGALMRQAEEREHTLRRCQQEGQELLRHNQELHGRLSEEIDQLRGFIASQGMGNGCG

RSNERSSCELEVLLRVKENELQYLKKEVQCLRDELQMMQKDKRFTSGKYQDVYVELSHIKTRSEREIEQLK

EHLRLAMAALQEKESMRNSLAE

Human Wildtype TRIODE Isoform5 cDNA

(SEQ ID NO: 29)

atggaggag gtgcctgggg atgccctgtg tgaacacttt gaggccaaca tacttaccca

gaaccgctgt caaaactgct tccaccctga ggaggcccat ggagcaagat accaggagct

caggagccct tcaggtgctg aggtgcccta ctgcgacctg cctcgatgtc cacctgcccc

tgaggaccca ctcagcgcct caacctccgg ctgccagtct gtggtggacc caggcctcag

gccagggccc aagaggggcc catccccctc agcagggctc ccagaagagg gtcccacagc

tgcccccagg agcaggagcc gggagcttga ggcagtaccc tatctggagg gcctgaccac

ttccttgtgt ggcagctgca acgaggaccc cggctctgac cccacctcca gccctgactc

cgccacccct gatgatacca gcaactcgtc ctctgtggac tgggacactg ttgagaggca

ggaggaggag gcccccagct gggacgagct cgcagtgatg atcccgagga ggcctcggga

ggggccgaga gctgacagct cccaaagggc tccgtctctc ctcaccaggt cccctgtggg

aggagatgct gcaggccaga aaaaggagga caccggcggt gggggccgga gcgcaggaca

gcactgggca aggctccggg gagaaagcgg gttgtccctg gagcggcacc ggtcaacact

gacccaggct tcctccatga caccacacag tggacctcga agcaccacgt ctcaggcttc

tcctgcccaa agggacactg ctcaggctgc ctctacacgt gaaatcccca gagcctcctc

tccccatcga atcacccaaa gggacacctc cagggcctca tccacccaac aggaaatctc

cagggcctca tccacccaac aggaaacctc cagggcctca tccacccaag aggacacccc

tagggcctca tccacccaag aggacacccc cagggcctca tctacacagt ggaacacccc

cagagcttcc tctccctcac gaagcaccca actggataac cccagaacct cttctaccca

gcaggacaac ccccaaactt cttttcctac ttgtactccc cagcgggaaa accccaggac

accctgtgtc cagcaggacg atcccagagc ctcctctccc aacagaacca ctcaacgaga

gaattccaga acatcctgtg cccagcggga caatcccaaa gcctccagaa cctcctctcc

caatagagcc acacgagaca accccagaac atcctgcgcc cagcgggaca atcccagagc

ctcctctccc agtagagcta cacgagacaa ccccacaaca tcctgtgccc agcgggacaa

tcccagagcc tccagaacct cctctcccaa tagagccaca cgagacaacc ccagaacatc

ctgtgcccag cgggacaatc ccagagcctc ctctcccagt agagctacac gagacaaccc

cacaacatcc tgtgcccagc gggacaatcc cagagcctcc agaacctcct ctcccaatag

agccacacga gacaacccca gaacatcctg cgcccagcgg gacaatccca gagcctcctc

tcccaataga gctgcacgag acaaccccac aacatcctgt gcccagcggg acaatcccag

agcctccaga acctcctctc ccaatagagc cacacgagac aaccccagaa catcctgtgc

ccagcgggac aatcccagag cctcctctcc caatagagct acacgagaca accccacaac

atcctgtgcc cagcgggaca atcccagagc ctccagaacc tcctctccca atagagccac

acgagataac cccagaacat cctgtgccca gcgggacaat cccagagcct cctctcccaa

cagaaccacc caacaagaca gccccagaac atcctgtgcc cgacgggacg atcccagagc

ctcctctcct aacagaacca tccaacaaga gaaccccaga acatcctgtg ccctacggga

caatcccaga gcctcctctc ccagcagaac catccaacaa gagaacccca gaacatcctg

tgcccaacgg gacgatccca gagcctcctc tcctaacaga accacccaac aagagaaccc

cagaacatcc tgtgcccgac gggacaatcc cagagcctcc tctcgcaaca gaaccatcca

gcgagacaac cccagaacat cctgtgccca gcgggacaat cccagagcct cctctcctaa

cagaaccatc caacaagaga acctcagaac atcctgtacc cgacaggaca atcccaggac

ctcctctccc aatagagcca cacgagacaa ccccagaaca tcctgtgccc agcgggacaa

tctcagagcc tcctctccca tcagagccac ccaacaggac aaccccagaa cttgtattca

acagaacatc cccagatcat cttctaccca acaagacaac cctaaaacct cttgtaccaa

acgagataac ctcagaccca cttgtacaca gcgggaccgc acacagtcct tttcctttca

acgagacaac cctggaacct cctcatctca atgctgcacc caaaaggaga atctgagacc

atcatctccc caccgctcca ctcaatggaa caatcccagg aattcatctc cccatcgtac

taacaaagac atcccctggg cctcgtttcc cctccggcca actcagagtg atggtccccg

aacctcttcc ccatctcgct ccaagcaaag cgaggttccc tgggcatcca tcgccctccg

gccaacccaa ggtgacaggc ctcagacatc ctctcccagc aggccagccc agcatgaccc

accccagtcc tcctttggcc ccacccagta caacttgcca tcccgggcca cctcttcctc

ccataaccca ggccaccaga gcacctcccg aacttcctca cctgtgtacc ccgctgccta

tggggctccc ctgacctctc ctgagccctc ccagcctcca tgtgctgtgt gcattgggca

ccgggatgcc cctcgagcct cttcgccccc tcgctatttg cagcacgacc ccttcccctt

cttcccagag ccccgcgccc ctgagagtga accgccccac cacgagcctc cctatatacc

acctgctgtg tgcattggac accgagatgc cccccgggcg tcctcgcccc cccgccacac

ccaatttgac cccttcccct tcctcccaga cacatcagat gccgagcatc agtgtcagtc

cccccaacac gagccccttc agctccctgc acctgtgtgt attgggtacc gagatgcacc

ccgggcctcc tccccaccac gccaggcccc agagccttcc ctcttattcc aggacctccc

cagggccagc acagagagcc ttgtcccttc catggactct ctgcacgagt gcccccacat

ccccacccct gtgtgcattg ggcaccggga tgcaccctcc ttctcatccc caccacgcca

ggctcctgag ccatccctct tcttccagga tccccctgga actagtatgg agagcctggc

cccctccact gactctctgc atggctcccc agtgctgatc ccccaagtgt gcatcgggca

ccgggatgca ccccgagcct cctccccacc ccgccaccca cccagtgacc tagcgttcct

ggcaccctca ccttcaccgg gcagctctgg gggctcccgg ggctcagcgc ctcccgggga

gaccaggcac aacttggagc gggaggagta cactgtgctg gccgacctgc ccccacccag

gaggctggcc cagagacagc cagggcccca ggcgcagtgc agcagcgggg gccgcaccca

cagccctggc cgtgcagagg tggagcgcct cttcgggcaa gagcgcagga agtccgaggc

agcgggggcc ttccaggccc aggacgaggg acggtcacag cagcccagcc aaggccagag

ccaacttctc cgaagacagt ccagccctgc ccccagcagg caggtgacca tgctccctgc

caaacaggca gaactgaccc ggcggagcca agcagagccc cctcatcctt ggagtcctga

gaagagacct gagggagatc ggcagctcca ggggtccccg ctgcccccca ggacatcagc

caggacccct gagagggagc tgcggacaca gagacctctg gagagtggcc aagcaggccc

aagacagcct ctgggggtgt ggcagagtca ggaggaaccg ccagggtccc agggccctca

tagacaccta gaaaggagct ggagcagcca ggagggaggc ctgggccctg ggggctggtg

gggatgtgga gagcccagcc tgggggcagc caaagccccg gagggagcat gggggggcac

ttccagggag tacaaggaga gctgggggca gccagaggcc tgggaggaga agcccactca

tgagctcccc agagaactag gaaagagaag cccactcacg agcccccctg agaactgggg

aggccccgca gagtcctcac aatcctggca ctctgggaca cccactgctg tgggctgggg

ggcagaggga gcgtgtccat acccgcgtgg ctctgagagg cgacccgagc ttgactggag

ggatctgctt ggccttctcc gggcaccagg agagggggtc tgggcccgtg tccccagcct

ggactgggag ggcctcttgg agctcctgca ggccaggctg ccccgcaagg acccagctgg

acacagggat gacctggcca gggctttagg gccagagctg ggtcccccag gcacaaacga

tgtccctgag caggagtcac acagccagcc agaaggctgg gccgaggcca ccccagtcaa

tggacacagc cccgcactgc agtcccagag cccggtccag ctgcccagcc ctgcctgcac

ctccacccag tggccaaaga tcaaagtgac aagaggacca gcgaccgcaa ctctggcagg

cctggagcag acgggccccc tggggagcag gagcactgcg aagggcccca gcttgccaga

gctgcagttc caaccagagg agcctgagga gtcagaacca agcagaggcc aagaccccct

gactgaccag aagcaggcag actcggcaga caagaggcca gcagagggca aggctgggag

cccgctcaag ggccgactgg tgacctcatg gcggatgccc ggggaccggc ccacgctgtt

caatccgttc ctgctgtctc tgggggtcct caggtggcga aggcccgatc tgctcaactt

caagaaggga tggatgtcga tcttggacga gcctggagag cctccctccc cctcgctcac

caccacctct acttcgcagt ggaagaaaca ttggtttgtg ctgacagatt caagtctcaa

atattacaga gactccactg ctgaggaggc agatgagctg gatggtgaga tcgacctgcg

ttcctgcacg gatgtcactg agtacgcggt gcagcgcaac tatggcttcc agatccacac

caaggatgct gtctatacct bitcggccat gacctcaggc atccggcgga actggatcga

ggctctgaga aagaccgtac gtccaacttc agccccagat gtcaccaagc tctcggactc

taacaaggag aacgcgctgc acagctacag cacccagaag ggccccctga aggcagggga

gcagcgggcg ggctctgagg tcatcagccg gggtggccct cggaaggcgg acgggcagcg

tcaggccttg gactacgtgg agctctcgcc gctgacccag gcttccccgc agcgggcccg

caccccagcc cgcactcctg accgcctggc caagcaggag gagctggagc gggacctggc

ccagcgctcc gaggagcggc gcaagtggtt tgaggccaca gacagcagga ccccagaggt

gcctgctggt gaggggccgc gccggggcct gggtgccccc ctgactgagg accagcaaaa

ccggcttagt gaggagatcg agaagaagtg gcaggagctg gagaagctgc ccctgcggga

gaataagcgg gtgcccctca ctgccctgct caaccaaagc cgcggagagc gccgagggcc

cccaagtgac ggccacgagg cactggagaa ggaggttcag gctcttcggg cccagctgga

ggcgtggcgt ctccaagggg aggctcctca gagtgcactg agatcccagg aggatggcca

catccccccg ggctacatct cacaggaggc atgtgagcgc agcctggcag agatggagtc

ctcgcaccag caggtgatgg aggagctgca gcggcaccac gagcgggagc tgcagcgcct

gcagcaggag aaggagtggc tcctggctga ggagacggca gccacggcct cagccattga

agccatgaag aaggcctacc aggaagagct gagccgagag ctgagcaaaa cacggagtct

ccagcagggc ccggatggcc tccggaagca gcaccagtca gatgtggagg cactgaagcg

agagctgcag gtgctatcgg agcagtactc gcagaagtgc ctggagattg gggcactcat

gcggcaggct gaggagcgcg agcacacgct gcgccgctgc cagcaggagg gccaggagct

gctgcgccac aaccaggagc tgcatggccg cctgtcagag gagatagacc agctgcgcgg

cttcattgcc tcgcagggca tgggcaatgg ctgcgggcgc agcaacgagc ggagttcctg

cgagctagag gtgctgcttc gcgtaaaaga aaacgaactc cagtacctaa agaaggaggt

gcagtgcctc cgggacgagc tccagatgat gcagaaggac aagcgcttca cctcgggaaa

gtaccaggac gtctatgtgg agctgagcca catcaagaca cggtctgagc gggagatcga

gcagctgaag gagcacctgc gtcttgccat ggccgccctc caggagaagg agtcgatgcg

caacagcctg gctgagtag

Human Full-length Wildtype TRIOBP Protein Isoform1

(SEQ ID NO: 30)

MTPDLLNFKKGWMSILDEPGEPPSPSLTTTSTSQWKKHWFVLTDSSLKYYRDSTAEEADELDGEIDLRSCT

DVTEYAVQRNYGFQIHTKDAVYTLSAMTSGIRRNWIEALRKTVRPTSAPDVTKLSDSNKENALHSYSTQKG

PLKAGEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRARTPARTPDRLAKQEELERDLAQRSEE

RRKWFEATDSRTPEVPAGEGPRRGLGAPLTEDQQNRLSEEIEKKWQELEKLPLRENKRVPLTALLNQSRGE

RRGPPSDGHEALEKEVQALRAQLEAWRLQGEAPQSALRSQEDGHIPPGYISQEACERSLAEMESSHQQVME

ELQRHHERELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRELSKTRSLQQGPDGLRKQHQSDVEAL

KRELQVLSEQYSQKCLEIGALMRQAEEREHTLRRCQQEGQELLRHNQELHGRLSEEIDQLRGFIASQGMGN

GCGRSNERSSCELEVLLRVKENELQYLKKEVQCLRDELQMMQKDKRFTSGKYQDVYVELSHIKTRSEREIE

QLKEHLRLAMAALQEKESMRNSLAE

Human Full-length Wildtype TRIOBP Protein Isoform4

(SEQ ID NO: 31)

MIPRRPREGPRADSSQRAPSLLTRSPVGGDAAGQKKEDTGGGGRSAGQHWARLRGESGLSLERHRSTLTQA

SSMTPHSGPRSTTSQASPAQRDTAQAASTREIPRASSPHRITQRDTSRASSTQQEISRASSTQQETSRASS

TQEDTPRASSTQEDTPRASSTQWNTPRASSPSRSTQLDNPRTSSTQQDNPQTSFPTCTPQRENPRTPCVQQ

DDPRASSPNRTTQRENSRTSCAQRDNPKASRTSSPNRATRDNPRTSCAQRDNPRASSPSRATRDNPTTSCA

QRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSPSRATRDNPTTSCAQRDNPRASRTSSPNRATRDNPR

TSCAQRDNPRASSPNRAARDNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSPNRATRDNP

TTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSPNRTTQQDSPRTSCARRDDPRASSPNRTIQQ

ENPRTSCALRDNPRASSPSRTIQQENPRTSCAQRDDPRASSPNRTTQQENPRTSCARRDNPRASSRNRTIQ

RDNPRTSCAQRDNPRASSPNRTIQQENLRTSCTRQDNPRTSSPNRATRDNPRTSCAQRDNLRASSPIRATQ

QDNPRTCIQQNIPRSSSTQQDNPKTSCTKRDNLRPTCTQRDRTQSFSFQRDNPGTSSSQCCTQKENLRPSS

PHRSTQWNNPRNSSPHRTNKDIPWASFPLRPTQSDGPRTSSPSRSKQSEVPWASIALRPTQGDRPQTSSPS

RPAQHDPPQSSFGPTQYNLPSRATSSSHNPGHQSTSRTSSPVYPAAYGAPLTSPEPSQPPCAVCIGHRDAP

RASSPPRYLQHDPFPFFPEPRAPESEPPHHEPPYIPPAVCIGHRDAPRASSPPRHTQFDPFPFLPDTSDAE

HQCQSPQHEPLQLPAPVCIGYRDAPRASSPPRQAPEPSLLFQDLPRASTESLVPSMDSLHECPHIPTPVCI

GHRDAPSFSSPPRQAPEPSLFFQDPPGTSMESLAPSTDSLHGSPVLIPQVCIGHRDAPRASSPPRHPPSDL

AFLAPSPSPGSSGGSRGSAPPGETRHNLEREEYTVLADLPPPRRLAQRQPGPQAQCSSGGRTHSPGRAEVE

RLFGQERR

Human Full-length Wildtype TRIOBP Protein Isoform6

(SEQ ID NO: 32)

MEEVPGDALCEHFEANILTQNRCQNCFHPEEAHGARYQELRSPSGAEVPYCDLPRCPPAPEDPLSASTSGC

QSVVDPGLRPGPKRGPSPSAGLPEEGPTAAPRSRSRELEAVPYLEGLTTSLCGSCNEDPGSDPTSSPDSAT

PDDTSNSSSVDWDTVERQEEEAPSWDELAVMIPRRPREGPRADSSQRAPSLLTRSPVGGDAAGQKKEDTGG

GGRSAGQHWARLRGESGLSLERHRSTLTQASSMTPHSGPRSTTSQASPAQRDTAQAASTREIPRASSPHRI

TQRDTSRASSTQQEISRASSTQQETSRASSTQEDTPRASSTQEDTPRASSTQWNTPRASSPSRSTQLDNPR

TSSTQQDNPQTSFPTCTPQRENPRTPCVQQDDPRASSPNRTTQRENSRTSCAQRDNPKASRTSSPNRATRD

NPRTSCAQRDNPRASSPSRATRDNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSPSRATA

DNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSPNRAARDNPTTSCAQRDNPRASRTSSPN

RATRDNPRTSCAQRDNPRASSPNRATRDNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSP

NRTTQQDSPRTSCARRDDPRASSPNRTIQQENPRTSCALRDNPRASSPSRTIQQENPRTSCAQRDDPRASS

PNRTTQQENPRTSCARRDNPRASSRNRTIQRDNPRTSCAQRDNPRASSPNRTIQQENLRTSCTRQDNPRTS

SPNRATRDNPRTSCAQRDNLRASSPIRATQQDNPRTCIQQNIPRSSSTQQDNPKTSCTKRDNLRPTCTQRD

RTQSFSFQRDNPGTSSSQCCTQKENLRPSSPHRSTQWNNPRNSSPHRTNKDIPWASFPLRPTQSDGPRTSS

PSRSKQSEVPWASIALRPTQGDRPQTSSPSRPAQHDPPQSSFGPTQYNLPSRATSSSHNPGHQSTSRTSSP

VYPAAYGAPLTSPEPSQPPCAVCIGHRDAPRASSPPRYLQHDPFPFFPEPRAPESEPPHHEPPYIPPAVCI

GHRDAPRASSPPRHTQFDPFPFLPDTSDAEHQCQSPQHEPLQLPAPVCIGYRDAPRASSPPRQAPEPSLLF

QDLPRASTESLVPSMDSLHECPHIPTPVCIGHRDAPSFSSPPRQAPEPSLFFQDPPGTSMESLAPSTDSLH

GSPVLIPQVCIGHRDAPRASSPPRHPPSDLAFLAPSPSPGSSGGSRGSAPPGETRHNLEREEYTVLADLPP

PRRLAQRQPGPQAQCSSGGRTHSPGRAEVERLFGQERRKSEAAGAFQAQDEGRSQQPSQGQSQLLRRQSSP

APSRQVTMLPAKQAELTRRSQAEPPHPWSPEKRPEGDRQLQGSPLPPRTSARTPERELRTQRPLESGQAGP

RQPLGVWQSQEEPPGSQGPHRHLERSWSSQEGGLGPGGWWGCGEPSLGAAKAPEGAWGGTSREYKESWGQP

EAWEEKPTHELPRELGKRSPLTSPPENWGGPAESSQSWHSGTPTAVGWGAEGACPYPRGSERRPELDWRDL

LGLLRAPGEGVWARVPSLDWEGLLELLQARLPRKDPAGHRDDLARALGPELGPPGTNDVPEQESHSQPEGW

AEATPVNGHSPALQSQSPVQLPSPACTSTQWPKIKVTRGPATATLAGLEQTGPLGSRSTAKGPSLPELQFQ

PEEPEESEPSRGQDPLTDQKQADSADKRPAEGKAGSPLKGRLVTSWRMPGDRPTLFNPFLLSLGVLRWRRP

DLLNFKKGWMSILDEPGEPPSPSLTTTSTSQWKKHWFVLTDSSLKYYRDSTAEEADELDGEIDLRSCTDVT

EYAVQRNYGFQIHTKDAVYTLSAMTSGIRRNWIEALRKTVRPTSAPDVTKLSDSNKENALHSYSTQKGPLK

AGEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRARTPARTPDRLAKQEELERDLAQRSEERRK

WFEATDSRTPEVPAGEGPRRGLGAPLTEDQQNRLSEEIEKKWQELEKLPLRENKRVPLTALLNQSRGERRG

PPSDGHEALEKEVQALRAQLEAWRLQGEAPQSALRSQEDGHIPPGYISQEACERSLAEMESSHQQVMEELQ

RHHERELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRELSKTRSLQQGPDGLRKQHQSDVEALKRE

LQVLSEQYSQKCLEIGALMRQAEEREHTLRRCQQEGQELLRHNQELHGRLSEEIDQLRGFIASQGMGNGCG

RSNERSSCELEVLLRVKENELQYLKKEVQCLRDELQMMQKDKRFTSGKYQDVYVELSHIKTRSEREIEQLK

EHLRLAMAALQEKESMRNSLAE

A non-limiting example of a human wildtype TRIOBP genomic DNA sequence is SEQ ID NO: 33. The exons in SEQ ID NO: 33 are: nucleotide positions 1-102 (exon 1), nucleotide positions 601-709 (exon 2), nucleotide positions 4319-4492 (exon 3), nucleotide positions 13440-13579 (exon 4), nucleotide positions 16223-16424 (exon 5), nucleotide positions 18776-18947 (exon 6), nucleotide positions 26198-29516 (exon 7), nucleotide positions 36311-36425 (exon 8), nucleotide positions 37412-38455 (exon 9), nucleotide positions 41655-41732 (exon 10), nucleotide positions 43908-44045 (exon 11), nucleotide positions 54785-54841 (exon 12), nucleotide positions 57890-57997 (exon 13), nucleotide positions 58114-58203 (exon 14), nucleotide positions 58563-58672 (exon 15), nucleotide positions 60626-61151 (exon 16), nucleotide positions 62167-62277 (exon 17), nucleotide positions 68683-68830 (exon 18), nucleotide positions 71087-71189 (exon 19), nucleotide positions 72041-72200 (exon 20), nucleotide positions 72275-72388 (exon 21), nucleotide positions 74663-74749 (exon 22), nucleotide positions 75614-75777 (exon 23), and nucleotide positions 76796-79569 (exon 24). The introns are located between each pair of these exons in SEQ ID NO: 33, i.e., at nucleotide positions 103-600 (intron 1), nucleotide positions 710-4318 (intron 2), nucleotide positions 4493-13439 (intron 3), nucleotide positions 13580-16222 (intron 4), nucleotide positions 16425-18775 (intron 5), nucleotide positions 18948-26197 (intron 6), nucleotide positions 29517-36310 (intron 7), nucleotide positions 36426-37411 (intron 8), nucleotide positions 38456-41654 (intron 9), nucleotide positions 41733-43907 (intron 10), nucleotide positions 44046-54784 (intron 11), nucleotide positions 54842-57889 (intron 12), nucleotide positions 57998-58113 (intron 13), nucleotide positions 58204-58562 (intron 14), nucleotide positions 58673-60625 (intron 15), nucleotide positions 61152-62166 (intron 16), nucleotide positions 62278-6862 (intron 17), nucleotide positions 68831-71086 (intron 18), nucleotide positions 71190-72040 (intron 19), nucleotide positions 72201-72274 (intron 20), nucleotide positions 72389-74662 (intron 21), nucleotide positions 74750-75613 (intron 22), and nucleotide positions 75778-76795 (intron 23).

Human Wildtype TRIOBP Genomic Sequence (NCBI Accession No. NG_012857.1)

(SEQ ID NO: 33)

1
cttccacctc ccgagcatcg ctctgattca ttgttaaaat aaagaggcca tgaccctggc

61
actcccaccc cggcagcccc tgtgcgtgga aacccagcca aggttagcac tgggcctcag

121
aaaagaggag ctggtagggg gaggcctaca ggaggggtag gggtcgaggg atccggggag

181
gaactggctg aatgcctgga tggagagggt cccgggtcca ttctctgggt ggggcatgtg

241
tagctgctta aggttttgat tattatatcc acatctcaag tgcattttag agaaggattc

301
tgcctattgg ttgtgggtag gggaggaaac gggagcagcg aggggcacgt ggagtagagc

361
cccctaccca cccccaggaa aatgagcggc gttctcctgc taggcgacgc tcctttatgt

421
ggccagacca ggagagaaac gcccaggacg ggcggggccg atgcgcccct cttccaccac

481
caggagtcgg gaggacgacc gcccggggag gatcagagac cctggggcca cggaaggacc

541
agtgggtagc cctctcccca ccgtgccttg ctgtcgcccc caccgcattc ccttctccag

601
gtctgatgat ggaggagcct tggccctggc tgtcccaggg gaggaggtga aattcctcag

661
ctctccacca agattggcca caaaagcctg atcccctgga acacagcagg tgaggatgga

721
tgtgggcagg tgacctgggg gcaccaaaag ctgcaggtgt tttgggatgt tgggttcctc

781
ccacccccca ccctccccct ggggctctgt gtgagtgggg aggccatctt taagtgattc

841
tcctgaccca gctccactcc agggcatgga tgttggtggc cttaggggca cccagaaagg

901
agaacccttg cacaagtaag ataccagggc ggccgggcgc ggtggctcaa gcctgtaatc

961
ccagcacttt gggaggtcga ggtgggtgga tcacaaggtc aggagttcga gaccagcctg

1021
gcccatatgg tgaaacctcg tctctaccaa aaatacaaaa aaattatccg ggcatggtgg

1081
cacatgcctg taatcccagc tatttgggag gctgcggcag gagaattgct tgaatccggg

1141
aggcagaggt tgcagtgagc cgagatcgcg ccactgcact ccagcctggg tgatagaccg

1201
agattctgtc tcaaaaaaaa aaaaaaaaaa agaaagaaag acaccagggt ttcagaaggg

1261
tatgatgctt cacacctgta atcccagcac tttgagggaa ggaggaggat tacttgaggt

1321
caggagttca ggagttcaaa accagcctgg gtaacactgc aagagccttt tttttttttt

1381
tttttttttt tgagacacac tgttgcccag gctggagtgc agcggggcga tcttagctcc

1441
actgcaacct ccacctcctg ggttcaagca attctcttgc cccagcctct tgagtagctg

1501
ggattacagg catgcgcacc acgcccagct aatttttata gttttagtag agacagggtt

1561
tcatcatgtt gggcaggctg gtcttgaatt cctggcctca agtgatctgc ctgcctcagc

1621
ctcccaaagt gctgggatta taggcgtgag ccaccgcacc tggccaagag cccattttta

1681
caaaataaaa aagaaaaaaa ttagctgggc gtggtggcgt acacctgtag tcccagttac

1741
tcagtcccag agactgaggc aggagaatca tttgagcccg ggagtttgag gttgcaagga

1801
gctatgatcg agccactgca ctccagcctg ggtgacagag caagaccctg cccccacctc

1861
cccaaaaaag acattagggg ccggatgcag tggctcacac ctgtaatccc agcattttgg

1921
gaggccgaag ggggcggatc acctgaggtc aggagttcac ctggccaaca tggcgaaacc

1981
ccgttgctac taaaaataca aaaattagcc aggcatgacg gtgcatgcct gtgatcccag

2041
atactactgg ggaggctgag gtagaattgc ttgaacccag gaggcggagg ttgcagtgag

2101
ccgagtgagc caagatcaca tcacggcact ccagcctagg tgacagagag agacttcgtc

2161
tcaaaaaaac aaaacaaaac aaaacgaaaa cacattagga tttctttttg gctaagttct

2221
gccacaaact tgctgtgtga ctttaggctg ttcacgtttg tcaaagacgt cgtcctcaac

2281
tctgaaaata cctggccagc tttttgcctc cctcgctgtg cttcccaagg gacctgtgcg

2341
agttggcagt atgatccagt gctcctcact tccacctccg agagagcagg gacacacaca

2401
gccctggatt tgaatcagcc actgcgacct tcagtgaccg aaggaacctc tctgagcctt

2461
agttgcctga tctaaaattg gcattaattt gatctacaat gcagctataa gacaaggaca

2521
ctcaaacttt ggggcgcact agaatcacct ggggaatcac tttttttttt taagacagag

2581
tctcactctt atcacccagg ctggagtaca gtggtgcaat cttggctcac tgcaacctcc

2641
gcctcctggg ttcaagtgat tctcctgcct cagcctcccg agtaactggg actacaggtg

2701
cataccacca tgcctggcta attttgtatt tttagtagag acagggtttg gcaatattgg

2761
ccaggctggt ctcgaactcc tgacctcagg tgatctgccc gcctcggcct cccaaagtgc

2821
tgggattata ggcgtgagcc actgcgcctg gccaggaatc gcttctttat tttcattttc

2881
atttatttat ttatttattt atttattttg agatggagtc tcgctctgtt gctcagtctg

2941
gagtgaagtg gcgtgctctc cgctcactgc tacctctgcc tcccaggttc aagcgattct

3001
cgtgcctcag cctcccaagt agctgggact acaggtgcgt gctaccacgc ccagctaatt

3061
tttgtattta gtagaggcgg ggtttcacca tgttggccag gctggtcttg aactcctggc

3121
ctcaagtgat ctgcctgcct cagcctccca aagtgctggg attacaggcg tgagccaccg

3181
ccctcggctg gaatcacttc tttaacatgc acagccccag acctcagtct cttggagatt

3241
ctaactgtgt gaattgggag agagaaaggg gaatctagat tttttttttt tttttttgag

3301
atgtggtctt gctatgttgc ctaggctgga gtgctgtaac tattcacagg tgcagttata

3361
gcacactacc acctcaaact cctgggctca agagatcctc ccacctctgc ctcccgagta

3421
gcttggactg caggtgcaca ccatcttacc cagctgaaat ctgctttttt tttttctcag

3481
tgcagtggca cagtcatggc tcactgcagc ctcgacctcc cagactcagg tgatcctccc

3541
aacttcagcc tcctgagtag cagggaccac aggcctgcac caccttgccc agctaatttt

3601
tgtatttttt gtagagacgg agtttcgcca gttgcccagg atggtcttga actcttgggc

3661
tcaaatgatc cgccgcccgc aatgggccca gctggaatct gcattttttt gttttttgtt

3721
ttgagatgaa gtctcactct gtcgcccagg ctggagtgca atggcgcaat cttggctcac

3781
tgcaacctcc gcctcctggg ttcaagccat tctcctgcct caggctccca agtagctggg

3841
attacaggca cgtgccatca cacttggctg atttttgtat ttttagtaga gacagggttt

3901
taccatattg gccaggctgg tctcgaactc ctgacctcaa gtgatcggcc cacctcggcc

3961
tcccaaagtg ctgggattac aggcatcagc cactgtgcct ggcctggtat ctgcattttt

4021
atgaacagcc caggagggtg taatgcagag tccttggcgt gcactttcag caacactgca

4081
gtaaggacta gaaatcgcac atcaaatgct ggcagagtgc ctggtgctta gtaggtgctt

4141
agtgagtgtt tgttgagtga ataaatgaac aggaatggat ggagaacagg aacccaaagg

4201
aatggatgag taaccttatt tccttggtcc ttgtctggaa actggggcaa ctggggctgg

4261
ggttcaggtg agtggccagc cagtcatctg gtctttgcct ccccctcatt tttgccaggc

4321
ctcacataga cggtcagcca ttggatcata ggaactgccc tggcctgact cacccaatat

4381
ggaggaggtg cctggggatg ccctgtgtga acactttgag gccaacatac ttacccagaa

4441
ccgctgtcaa aactgcttcc accctgagga ggcccatgga gcaagatacc aggtgggcca

4501
gttttccacg tggttggggt ggtttgtgat gggggcatgg gtgaaggact gggcctgtgg

4561
tgtccgctaa ctcgcagttg aacccagatg ctggacttcc tcctgtcgag agcctcggtt

4621
ttcccacatt gcagggaagt ggttgaacca tgtgaatgtt tcacaatctt cagtcacttt

4681
cctcctgctt atatgatacg attgttacca tagccttatc taatctgtta cttactttgt

4741
tattctttaa atcaacatct ttttcccctt ctattgaaac aaaacttcac atcatcaaca

4801
caagtagaaa actagaatta cttcctgtta agaagaagag gttaagaaga aaggtagagg

4861
ctgggcacgg tggctcacgc ctgtaatccc agcactttgg gaggccgagg tgggtggatc

4921
acccgaggtc gggagtttga aaccagcctg gccaacatgg tgaaaattag ctgggcatgg

4981
tggtgcatgc ctgtaatccc agctacttgg gaggctgagg caggagaatc acttgaacct

5041
gggaggcgga gattgtggtg agccgagatc gcgccattgc actccagcct gggcaacaga

5101
atgaaactgt ctcaaaaaac aaaacaaaac aaaacaaaaa agagaagaaa ggtagaaaaa

5161
gaaaaaacaa aacagaaatg tcgttacacc ctaacttgag agtgttttct ttttcttttt

5221
cttttttttg agacagagtc tcactctgtc gcctgggcta gagtgcaatg gcaatggtgt

5281
gatctcagct cactgcaatc tctgcctcct aggttcaagc gatcctcccg cctcagcctc

5341
ccaagtattg ggattacagg tgcctgccac catgcccagc taatttttgt atttttagta

5401
gaaacggggt ttcgccatat tggccaggct ggtcttaaac tcctgacctc aggtgatcca

5461
cccgcctcag cctcccaaag tgttgggatt acaggcgtga gccaccgcgc ctggcctcga

5521
gagtgttttc tatggaaggc tctgagcttg catcctgctg tctctttgtc aaaaagggag

5581
attagcagat gttagagaga tgttaagaat acaccagcat catctagaga ttttctttct

5641
ctctctcttt tttttttttt tttttttttt tggagatagg gtcttgctct gtagcacagg

5701
ctggagtgca gtggtccaac ctatagtaca tggctcactg tagcctcgac ctcccaggct

5761
caaatgatct tcccaccttg gcctcctgag tagcagggac tacaggcaca tgccaccatg

5821
gccagctaat tttcttgtaa agatgggatc tcactatgtt gccagggctg gtctcaaatt

5881
cctgggctca ggtgatcctc ccacctcaac ctctgtaact gcagggatta caggtgtgag

5941
acactgcacc tggtctcaag attttcttct tcaagttatt gaaggagtga agaagaatcc

6001
ttttttttct ttcttttttt ttcatttgag acggagtctc tctctgtcgc caggctagag

6061
ttcagtggct caatctcagc tcactgcaac ctccgtctcc tgggttcaag caattctcct

6121
gcctcagcct cctgagtacc tgggattaca ggtgcccacc accatgccca gctaattttt

6181
gtatctttag tagagacagg gtttcaccat gttggtcagt ctggtctcga actcctgacc

6241
ttgtgatctg tctgcctcgg cttcccaaag tgctgggatt acaggtgtga gccaccgcgc

6301
ctggccgaga ttttcttctt caagttattg aaggagtgaa gaagagtcct tttctgactt

6361
tgtgattgat gtagtctgct gccaagcccc catgcatgta aacacagagc acctgataca

6421
cacgcaatga gaaacctggg actcacgaac ctccgagggc ccttccaacc ttgaccacca

6481
tggcttcgtc attcccattg gggtctgaag gtcctctttt tttttttttt tttttgagac

6541
agagtctcgt tctgttgccc aggctggagt acagtggtgc gatctgggct cactgcaagc

6601
tcggcctccc aggtttatgc cattctcctg cctcagcctc atgagtagct gggacaacag

6661
gcacccggca ccacgcccag ctaatttttt gtctttttag tagagacagg gtttcaccat

6721
gttagccagg atggcctcga tcttcctgac ctcgttattc gcccacctcg acctcccaaa

6781
gtgctgggat tacaggcatg agccaccgcg cccagcttct accagtcttg atacctccaa

6841
taatagctct cttgtgctca cctgcaagtt caggttcagg gaacagatgc ctgggagtcc

6901
atctttcatg caaatgactt tcttccagtg gttgggaaga tggcaagaat ggaacaggag

6961
agccgtggat tcaggctcgt ctgagttcta gtctcaatcc caccatttcc cacccgagac

7021
cgtgggtcag ctcacaaatt catacgtact gaataggtgc ttaaaatgtg ccaggcatta

7081
tgctagatga tggggaaatc atgataaatc agaaaggcac agccaggcac agtgactcac

7141
tcctgtaatc ccagcacttt gggaggccaa ggtgggtgga tcacttggag tttgagacca

7201
tcctggcaac atggcaaaac cccatctcta caaaaaattt aaaaaattag ctgggcgtag

7261
tgggatgcgg ctatagtctc agttactcag gaggctgagg tgggagaatc acctgagact

7321
gggaggcggg ggcttcagtg agccgtgatc gcattactgt atttcagcct gggtgacaga

7381
gttggaccct gactcagaac agaacagaac agaacagaac agaacagaac agaacagaac

7441
agaacagaac agtacagaaa acagggagaa ggaggggaag ggggagggga agggggaggg

7501
ggagagagag gaggagagga ggagagaggg acacatccct ggcttgtctt catggggctt

7561
atattctagc aagagaaatg cacatgatta tttaatcttg gttgtgataa atgtataaag

7621
gaacagtaag tggcatgaag gtaaaggata gggcattagg gaaagtttct ccaaaaaaaa

7681
aaaaatgaca tttcagctgc ttagtaaagg ctgtgcaggc attagcatta gtgaaattgc

7741
aggaagagga gaggaaggaa ggagaatgtg caaaggccag cctggcacgg cagctcacgc

7801
ctgtaatccc agcactttgg gaggaagtgc ttggattgag gcaccgaagc aggaagatca

7861
cttgaactca ggagtttgag accagcctgg gcagcacagt gagaccccat ttctaccaaa

7921
aaaaaaaaaa aaaaaattag ccaggcagga tggtgcacac ctgtagtccc agctagtcag

7981
aaggctgatg tgggaggatt actggatccc aggagttcaa ggttgcagtg agccatgagc

8041
atgccaatgc actccagcct gggcaacaga atgagacctt gtctcaaaaa caaaacaaac

8101
aaacaggtca ggtgcagtgg ttcatgcctg taatctcagc actttacgag gccgagacgg

8161
gtggatcacc tgaggtcagg agttcaagac caccctggcc aacatggtga aaccccatct

8221
ctattaaaaa tacacaaatt agctacatgt ggtggtgggt gcctgtaatc ccaggtactt

8281
aggaggctga ggcaggagaa tctcttgaac ccaggaggca gaggttgcag tgagccaaga

8341
ttgcaccact gtactccagc ctgggcaaca gagcgagaat cctctcaaaa caaaacaaac

8401
aaacaaagaa tatgcaaagg ccctgaggca gaaaggaggc tgcacatcgg gctggagagg

8461
acaggcaaga ggggggcaca gaggagctat aggacaagga tggagaatgg ggggaggcct

8521
ggtctcactg gccttgtgcg gctttgtgga catgttgagg acttaggatt ctgaggtttt

8581
tttctgtttt gtttttgttt ttttttgaga tggagtctcg ctctgtcgca caggctggag

8641
tgcagaggcg tgatctcggc tcactgcaac ctctgcctcc caggttcaag cgattctcct

8701
gcctcagcct cccaggtagc tgagactaca ggcatgtact accaaaccca gttaattttt

8761
gtatttttag tagagatggg gtttcaccat gccgctcagg ctggtcttga actcctggcc

8821
tcaagcaatc tgccctcctt ggcctcccaa agtgctgaga ttacaagtgt gagccacctc

8881
gcccggccaa gccacggaag atttcaaata agggagtgac gtgctctgat ttgcattttt

8941
cacagtcact ctgattgctg ggcagagaga atggagggca gggtggtgag agtgaatcag

9001
gtgacccgcc aggaaaaggt gcacgtactc atcggtgcca gagatgattg gggctttgag

9061
atggaggcaa atggacacat ttccgaacta attgagcagg cacgtctaca ggatttgggg

9121
gtgagggagg ggagaaaccc atggctgact cctgtaattt cttcaggcag ggtacttggg

9181
ttgggaggtc tgtttggagt tgtctggggc atggtgtggg gtgtcggcag gatacagtgg

9241
agatgagggg gaagttagtg aattggtggg gctggagctc agagccagac catcacagga

9301
gatggaggcc tgcgagtctt caggatctgt cactgaccaa agtcttgctc acggatgagc

9361
ctatcatctg tggaagaaag tgtggaatga gatgagaaca ggcctgggtg gaggccaggg

9421
aatcagcaga gacagccaag aaggccagag gctaggaggc aaaccccaca gtgtgcccct

9481
cctccccagg agccaagacc agagatggtt tcaagagagg gggccaggca caatggctcc

9541
cgcctgtgat cacagcactt taggaggctg aggctaaagg atggcttgaa accaggagtt

9601
taagaccagc ctagttaaca aagtgagatc ccatctctac aaaacaaaaa atgaactggg

9661
tgtagtggtg catgcctgca gtcccagcta cttgggaggc tgaggcagga ggattgtttg

9721
agcccaggag attgaggctg cagtgcactg tgatcatgcc actgccacag caagactatc

9781
ttaaaaaaaa aaaaaaaaga tcagagaggg gcacgacatc aaatcctcca ctttcttgag

9841
cttccagttg ctctgatgat gatcaaggct gtgaaactct cctttggcaa atgcatgagg

9901
ggtgactgtt gtgtctccga gccaggccct gggacccaac tctgggcagg tagcagctcc

9961
ctgtgtatac cagatgtgat agtaaaaaac tgacactggg ccgggcgcgg tggctcacgc

10021
ctgtaatccc agcactttgg gaggccgagg cgggtggatc acttgaggtc aggagtttga

10081
gaccagcctg actagcatgg tgaaatcctg actctactaa aaatacaaaa atacaaaaat

10141
taacagggtg tggtggcgga tgcctgtaat cccagctact cgggaggctg aggcaggaga

10201
atttcttgaa tccgggaggc ggaggttgca gtgagccgag atctggccac cgcactccag

10261
cctgggcgac aagagcgaaa aactccatct caaaaaaaac aaaaaaacct cctgggcccc

10321
agaagatggc aactgcctct tccagcctct tccacctgcc tgcctgtgca ctcctctgcc

10381
actctggacc tattccatgg tgccacgtgg tcaggcattg aaggaatggg tgggtttttt

10441
ttccatcacc ctcagatgct gctgctgggg ttggggcggg tcttccctgg ctgactctgt

10501
ctgcctcacc cactctctcc ccatctctct gtcaccacag gtctccaggg accaaattta

10561
gcccattttt cctccaagga ttctggaccc ttggccatat ttgcctctag ctttaggtca

10621
acagatttct aacatggagt caaaaaatct gtatgtttaa aaaaaaaaaa ttggctggga

10681
gtggtggctc acgtctgtaa tcccagcact ttgggaggcc gaggcaggtg gatcacctga

10741
ggtcaggagt tcgagaccac cctggccaac atggtgaaac cccgtctcta ctaaaaatac

10801
aaaaattagc tgggtatggt ggcggacccc tgtagtccca gctactcagg aggctgaggc

10861
aggacaattg cttgaacccg ggaggcagag gttgcagtga gctgagatcg cgccattgca

10921
ctccagcctg ggtgacagag tgagactctg tctcaaaaaa aagaaaaaaa aaaaaaaggc

10981
cgggcgtggt ggctcacggc tgtaatccca gcactttggg aggccgaggc gggcggatca

11041
cgagatcagg agatcgagac catcctggct aacacggtga aaccctgtct ctactaaaaa

11101
tacaaaaaat tagctgggca tggtggcggg cgtccatagt cccagctact cgggaggctg

11161
aggcaggaga atggcatgaa cccgggaggc ggagcttgca gtgagccaag atcacgccac

11221
tgcactctag cctgagcgac agagtgagac tccgtctcac aaaaaaaaaa aaaaaaaaaa

11281
attgaggcca ggcacagtgg ctcatgcctg tgatcccagc actttggccg aggcaggcag

11341
atcacctgcc atcaggagtt cgagaccagt ctcgccaaca tggcaaaccc ctgtctctac

11401
taaaaataga aaaattagcc gggcatggtg tcgggcacct gtaatcacag ctactggggt

11461
ggctgaggca gaagaattgc ttgaacccag gaggcgaagg ttgcagtgag ccgagactgc

11521
accattgcac tctaacctgg gctataagag cgagactctg tctcaaaaaa aaagcccttt

11581
acaaatatta actcgtttaa ttctcagaac acccctagga ggtgggtcct gctatcctgc

11641
cggttttgta gatgaggtaa ctgaggcaca gagaggataa gtcacgtggc ccaggtcttg

11701
gtcgcttctc agcctccatt tccgagagga gaaaacaatg ctccgaaagg ggaagtcatc

11761
ggcctgaggt caccagccgg gaaccggagg agccaggatg gggcccgagg tccatctgag

11821
gccagagcca gtgctgaccc gccagacagg aaatcagagc tggggactga ccgtggggcc

11881
cactcaagtg ggtggtgtgg ggtggtgacg ggggctgggg tgaaagccag gatgaggtgt

11941
cacattaggc tagggttcct gctgggcctg gcggggcaga gacccctggt tgatgcctgg

12001
caagtctctc ctcatttctg ctgtgctgtc ccctgggtgg ccaaggcgcc aggcccggct

12061
gtggatctga cacctcctgc tgccgagctc tgatcagaat ctggctgcag ggcagggggt

12121
gaaactgaat cccaccaggc ctcccctggc ctggatgtca cggcagacat cccaacccca

12181
cttcttggca ctgcctgacc ccagcagtgg ccttcttgga acctggagag cctgtgccca

12241
ccctgtggtg ccgaccaggc tgctgccttg gccctgggct ctgggctcca gggtccccag

12301
ggatcccagg cccaggctct tgcccctccc ggctctcagg tgagctgctg ggatcgggtt

12361
cctgcggttt catgtctttc attgttcttg gctggggccc ggcttatgaa actgtaatga

12421
ggggcccctg ctcccgaagc cggcccctct aaggtttcca ctgcctcggc ggctgctgcc

12481
accacagccc ggagtcgggg cctgggaggg cagcagtgtg ggggcctgag ccggagcccc

12541
ccggggacga gggtgctgac agtcgacagc caccaccacc accagagccc gcagcccagg

12601
taatccgaga ggaggcgggg cgcagggtgc catggccgct gtctcccacc accaggggag

12661
ggaactgccg ctctccagag gtggggagga attggggggg gccctggagg tgagcagccg

12721
ttcccccctg gtgagcccag caccagacca gccttcacag gtgtggcctt gccaaaggtg

12781
gagggagaga ggagtgggca gctggctcta gcccccgccc ttttcctggg gccttgaccc

12841
tccagccctg gatcccctgc ctctccttta gtggggcaaa tctcttctgt cctccaagac

12901
cttgctttcc catctcctct accatcaaac tgcctcttcc tccctcagac ctctcccttc

12961
tctcagccag cctaatcctt cctcctcgcc cttgtctttt ggccgcaaaa gaccctggtg

13021
gatccttcta tccacctcgt tctggggcgc acgcacatac atgcatgtat acatgaagtt

13081
gcactcatgc aaacgtacag atcggtgtac ccgcgggacc tgcgtagaca cgcatgcgca

13141
agagctcgct ccacctatgt gcacacatgt gcccccaata ccaggccttt atccacacac

13201
atacctgctc caaggcccat atgtgtacac tcacgtgtgc aggcacacac caggtacctc

13261
agccagccct cggcttgagt cccaaggggt gcttctagcc tgatgggcag ctccttgaga

13321
agtgcaggat cccccgagga gatgcctgga gactcccacg ccaccgggag gggctgtgca

13381
gggggagggg agcccccacg tgggcgctga gctgtctcct ctctccaacc ctggcccagg

13441
agctcaggag cccttcaggt gctgaggtgc cctactgcga cctgcctcga tgtccacctg

13501
cccctgagga cccactcagc gcctcaacct ccggctgcca gtctgtggtg gacccaggcc

13561
tcaggccagg gcccaagagg tgggtagagt cccagggccc aggaagggct tcatggggtg

13621
gaatgccctc acccttccca tttgcactcc ttccccaagg cagcacctgt ctctaatggc

13681
tgctggcatg ggtcacgtgg tcagtcctct aaacctaggc acaggtgggt ggtgggcatg

13741
ctccttgggc ccacaggaag aactcagatc acaccaccct gtttgcactt cagtggctga

13801
gcctcccctc cccagtcctg gctgtctctc ccaggggccc tgcccacccc ataacctccc

13861
aagaccgagc tcagctttgc cccagggtgt gtggctgctg tacactcacc ttgcagtggg

13921
catggccaca gcctactcac atttcctggt tccctttgca cagctttaaa agattaaaca

13981
gtccctgcac ccaggggcac ctgctgtcac ccacctacgt gggtgtgcac tgctccaggc

14041
tctggggttc cttccaccct caggcctgag tggcagtccc cctttaaggt catggtacct

14101
tgggaggcca tggtctgaga gtctagaaac ctgggttcca gcttcagatc catccctgat

14161
gggtcttgag caagttactc tgtctttctg tgtctcagtt tccctctctg taaaataaga

14221
gggattgaat taaatcagca ttgtgctggg atcattcatg tgctcctcac aggtaggcat

14281
attaaaacaa acaaacaaac aaaaaaacag cctgggtgca gtggctcatg cctgtaattc

14341
cagaactttg ggaggccaag gtgggcggat cacttgaggt caggaggtcg agaccagcct

14401
gaccaacatg gcgaaaccct gtctctacta actatacaaa aattagccag gcatggtggc

14461
aggtgcctgt aatcccagct gctcgggagg ctgaggcagg agaaccactt gaacccggga

14521
ggcagaggtt gcagtgagtt gagatcgtgc cattacactc cagcctgggt gacacagcga

14581
ggctccgtct caaaaaaaaa aaaaacaaca aaaaaaaaaa acaaaaaaaa acccacaaaa

14641
aaacgaaaaa aaaaacaaag acagctttgt tatcaagtat gtttcagaaa gtctgggata

14701
aatgaagttg aatagctttc ctgcaggact tgtcagagcc tttagcttgc ctgcgtgcat

14761
cgtggctttt gggtaacgga agtagagaag tatgtcattt gactacagag ctctttttta

14821
tggccatcac ttattatcat cgtgtaggcc agtctgtggg tcactctttg gggatactgc

14881
cagcgctaag ccttcttgag cctgtgactt cttttaaagc agagccttct ctgcagctcc

14941
ctccctcagc atctgggcta gtgaacccgt caatgcctgt ggagccatgc tgcctctcac

15001
atcctcgtta gccaagcatg agtctgtctt cttagactta ctgaacttgg ggtcagtaga

15061
ctaagactaa gacttaaagt tggggctggg gcaatagttt tggttcataa cacagctctg

15121
ccctttccta tctcggtgac cttggccagt ctcttgacct ctctgagcct cagtgtcttc

15181
ctctgtgaaa tgggaattat tattattatt attattttga gatggcatct tgctctatca

15241
cccaagctgg agtgcaatga cacgatgttg gctcactgca acctcagcct cccgagtagc

15301
tgggattcca ggcatacacc accacacccg actaattttt gtatttttat ttatttattt

15361
ttgagataga gtctcgtgct gtcacccagg ctggagcgca atggcacgat cttggctcac

15421
tgcaacctcc acctcctggc ttcaagcgat tatcttgcct cagcctcctg agtagctggg

15481
attacaggtg tgtgccacca ccatgcccat ctaatttttt tatttttagt agagacgggg

15541
tttcaccatg ttggacaggc tagtctcgga ctactgacct caggtgatcc acccaccttg

15601
acctcccaaa gtgctaggat ttcaggtgtg agccactgcg cccggcctaa aatgggaatt

15661
attatactta ctttaaaggg atgctgttgc tgggcgcagt ggctcacgcc tgtaatccca

15721
gcactttggg agtccgagac gggcggatca cgaggtcagg agatcgagac catcctggct

15781
aacacggtga aaccccatct ctactaaaaa atacaaaaaa ttagccaggc gtggtggcgg

15841
gcgcctgtag tcccagctac tggggaggct gaggcaggag aatggcatga acctgggagg

15901
cagagattgc agtgagccga gatggtgcca ctgcactcca gcctgggtga cagagcgaga

15961
ctctgtctca aaataaataa ataaataaat aaataaataa ataaataaat aataaaatta

16021
caaaaaaaaa agggatgctg ttttagctca atgaggcaat ccatataaaa agtctgacac

16081
agaggcagct ctcaccattg gctccctttc ccacaccagc gtgtgggccc caggctccct

16141
gtgtgagtga gtgcatatgc ctgggtgggg tgggggatgc tcctaactcc ccattacttt

16201
ttgggtctgt ctcctctccc aggggcccat ccccctcagc agggctccca gaagagggtc

16261
ccacagctgc ccccaggagc aggagccggg agcttgaggc agtaccctat ctggagggcc

16321
tgaccacttc cttgtgtggc agctgcaacg aggaccccgg ctctgacccc acctccagcc

16381
ctgactccgc cacccctgat gataccagca actcgtcctc tgtggtgagc caggagtggg

16441
agtttggggg acaagagtgg ctcacacctc catctgcagc cctgggtccc acctaaacct

16501
ccaggccagg gctgagcctc acaccaggga atccgacgag gtcctctgga ccattagctg

16561
gcagctcggg ccaccccggc gaacccctgg agagtgggga tttctgcaca ggctggccca

16621
gggcagctgg ggtctggctg tgaaaagaca gggaaaggag tttcagccga caggagctct

16681
gggtgaatca ccagcaggct cgggctgcca catgctctca gatcccagag tgttgggttt

16741
ggtgtctagc gcaagagtgg cacagggccc cagggccctg ccctcgacac acagtgctga

16801
gtcccatggc cagccctgga atagatttcc aagagacaga ggaaagggag caggctgcgg

16861
gggtcattta accacgaaaa gagaagagcc agcagtcttt cctccagcat ttgcattttg

16921
aggggctgcc gcagagcaga agagacaggc ttgtcccagg agacccccca aaaggaaaat

16981
gacagggggt ggtgataaga ctcagaataa aacaacccag cctcacacgc ttcatggcca

17041
gctccatgct aagggcttgg tgggtgtggg ctcaggggag actcaccaca gcctcagaag

17101
tggagatttc agtcgcccca tatggggctg aggctcagcg gggggagcaa cttagtggag

17161
gccacacatc tgggaagtag tggggctagg atttgaaccc acttttctct ggcccctggg

17221
gctacctcac acagtcccac atgcggaact ctgggactct gggcaaagct cttggcttca

17281
atggatgtac atgcctccta ggtccgttga agatgagcga cttggcactt agcacctgct

17341
agagcccagc acagtgccag gcaaacagca catgctttta atttaattga ttgattgaag

17401
actgggtgcg gtggctcacg cctgtaatcc cagcactttg ggaggccaag gtgggcggat

17461
cacctgaagt caggagatcg agaccagcct ggccaacatg gtgaaactct gtctctacta

17521
aaaatacaaa aattagcagg gtgtggtggt gggcacctgt aatcccagct acttgggagg

17581
ctgagacagg agaatcgctt gaacccggga ggttgcagtg agcttagatt gcaccattgc

17641
actccagcct gggcaacaag agcaaaactc cgtcttaaat agagaaaaaa aaaaaagttg

17701
attgattgag acagggtctt gctccattgc ccagactgga atgcaatgat gtgaacatgg

17761
ctcactacag ccttgacttc ctgggctcaa gtgatccccc cacctcagcc tcctcagtag

17821
ctgggactat aggcatgcac aaccatgcct agttattatt atttttttta attttgtaga

17881
gacagggtct cactgtgttg cccagcctgg aagtgctttt tactgaggcc atggagcgga

17941
gtctacacca cagaaggtgt ggcaccactc actgtcacct cttggggaca gaacttgaca

18001
gtttaggaag tgctttttat tttttattta attttattta tttttgagat ggagtcttgc

18061
tctgtcacct gggctggagt gcagtgccac aatctcagct cactgcaacc tctgtctccc

18121
aggttcaagc gattcgcctg cctcagcctc tcgagtatct gggattacag gcgcccacca

18181
ctatgcctgg ctagtttttg tatttttaat agagacaggg tttcaccatg ttggccaggc

18241
tggtttcgaa ctcctgccct caggtgatcc acctgcctca gcctcacaaa gtgttgggat

18301
tacaggcgtg agccactgcg ccctgcaggg aagtgctttg tttttttttg ttttgttttt

18361
ctttttgttt tttgagacag agtctcactc tgtcacccag gctggagctc agtggcgcga

18421
tctccactca atgcaagctc cacctcccag gttcacacca ttctcctgcc tcagcttccc

18481
aagtagctgg gactacaggt gcccgccacc acgcccagct aattttttgt attttttagt

18541
agagatgggg tttcaccatg tttcccagga tggtctcgat ctcctgacct cgtgatccac

18601
ccacctcgtc ctcccaaagt gctgggattg caggcgtgag ccacagcgcc tggccaggga

18661
agtgcttttt aatgccaatt cccttccctt ccttctgccc ctctcatttg gagagtatat

18721
gtcctgcagc cttttttctc ccgcaaacat actttctcct ccccttctct ggcaggactg

18781
ggacactgtt gagaggcagg aggaggaggc ccccagctgg gacgagctcg cagtgatgat

18841
cccgaggagg cctcgggagg ggccgagagc tgacagctcc caaagggctc cgtctctcct

18901
caccaggtcc cctgtgggag gagatgctgc aggccagaaa aaggagggtg agtccttctg

18961
ccaggttggt tcccatggtg atggcctggg gccccccaga tagccatctc actggccatt

19021
tgggactctg ggcacggctt actttggtgg cctgagtgtt aataatagta acagtttgca

19081
tgtcatgatg gagcagccac aatgagttat gctacccact ttaattatta ttattattat

19141
ttgggatgga gtcttgctct gttgcccagg ctagagtgca gtggtgtgat ctcggctcac

19201
tgcaaccttt gcctccccag ttcaagcgat tctcctgccc cagcctccca agtagctaag

19261
attacaggct cccgccacca tgcccagcta atttttgtct ttttagtaga catggggttt

19321
caccatgtta gcccagctgg tctcaaactc ccaaccttca gtgatctgcc catcttggcc

19381
tcctaaattg ccgggattac aggcgtgatt acaggcacgc ctagcctgtt attattatta

19441
ttattactat tattattttg agataagagt ctcacactgt tgcccagact ggagtgcagt

19501
ggtgccctct tggctcactg caacctccgc ctcctgggtt caagagattc tcctgcctca

19561
gcctcctaag tacctgggat tacaggcacc cgccaccaca cgtggctaat ttgtgtattt

19621
ttagtagaga cagggtttca ccatgttggc cgggcttgtc tcaaattcct ggctggggat

19681
tacaggagtg agccactatg cctggcctta gccaaggagt ttggacttct ctaaatagta

19741
gggagccacc gaaggttttt gaggaggaaa gtcatgtaat taaacctgtg cctcaggaag

19801
ttccctagat caaagatgca aaggatgaat tggagcaggg aggggttgaa ggatgagaaa

19861
ccagttaaga gactgttgca ggcactgtag caataactgg ttcaggcatg aatcactggc

19921
ggatgcaaaa tccctagggt gataatttgt cagcaaacag gatagtcatg gtttcaaagt

19981
attgtgtccg gaattggtgg gttcttggtc tcactgactt caagaatgaa gcggcagacc

20041
ctcgcgatat tacagttctt aaaggcggcg tgtctggagt ttgttccttc tgatgttcgg

20101
atgtgtttgg agtttcttcc ttctggtggg ttcgcggtct cgctggctca ggagtgaagc

20161
tgcagacctt tgtggtgagt gttacggctc ttaaggagac gcgtccgcag ttgttctttc

20221
ctccctgtgg gttcatggtc tggatggctt caggagtgaa gctgcagacc ttcgtggtga

20281
gcgttacagc tcataaaggc agtgtggacc caaagagtga gcagcagcaa gatttattgc

20341
aaagagcgaa agaacaaagc ttccacagca tggaagagga cccgagcggg ttgccagagc

20401
tggctggggc agcctgcttt tattctcttg tctggcccca cccacatcct gctgattggt

20461
ccattttaca gagagccgag tggtctgttt tgacagggcg ctgattggtg catttacaat

20521
ccctgagctt gacacaaagg ttctccacat ccccactaga ttagctagat acagtgtcca

20581
cacaaaggtt ctccaagtcc ccaacagagt agctagatac agagtgtgga ttggtgcatt

20641
cacaaaccct gagctagaca cagggtgctg attggtgtgt ttacaaacct tgagctagag

20701
acagagtgct gattggtgta tttacaatcc cttagctaga cataaaggtt ctccaagttc

20761
ccactacact caggagccca gctggcttca cccagtggat ctcgttctgg ggctgcaggt

20821
ggagctgcct gccagtccca tgccatgcgc ccacactcct cagcccttgg gtggttgatg

20881
ggactgggcg ctgtggagca ggggcggcgc tcatcgggga ggctcgggct gcacaggagc

20941
ccacggaggc ggggggaagc tcaggcatgg cgggctgcag gtcccgagcc ctgcccggtg

21001
ggaaggcagc taaggcccgg cgagaaatcc agcgcagcgc tggtgggcgg gcactgctgg

21061
gggacccagc acaccctccc cagccgctgg cccaggtgct aagcccctca ttgcccgggg

21121
ccggcagggc cagccggccg ctccgagtgc ggggcccacc aagcccacgc ccacccggaa

21181
ctccagctgg cccacaagcg ccgcgcgcag cctcggttcc cgctcgcgcc tctccctcca

21241
cacctccgtg caagctgagg gagccagctc cggcctcggc cagcccagga aggggctccc

21301
acagtgcagc ggtggcctga agggctcctc aagtgccgcc aaagtgggag cccaggcaga

21361
ggaggcgccg agagtgagcg agggctgtga gggccgccag catgctgtca cctctcagta

21421
tcacccctca gattctgcat cgattactga gagaaaggca cccttaggct ggggagagcg

21481
ggaagatacc actttcacca agaggctgct cagcatcccc agagtggggc aaaccaacat

21541
aatatgcccc ctgatatgat gcatggggtc aggggagggg atgctggggt gggcacagaa

21601
tcccttccct tctaaatcgt cctgctgaaa atgcattgcc tacacctaac cccagtgaaa

21661
catcagacaa acccgaattg aaagacattc tgcaaaatga ctgggctcct cataggacaa

21721
aaagcggcta ggggactctt cttgattaaa agagactaac aggatgagga cgtggaatgc

21781
catgtgtgag cccattggga tctgggacag gaggacacag agctgtgaca ggcattactg

21841
ggacaactgg ggcttgtttt tttttttttt tttttttgag atggagtctt gctctgttcc

21901
ccaggctgga gtgcagtggc gcgatctcag ctcattgcaa cctccacctc ctgggttcaa

21961
gcgattctcc tgcctcagtc tcctgagtag ctgggactat aggtgcctgc caccacgccc

22021
agctgacttt ttgtatttct agtagagaca gggtttcacc atgttgagcc tgatgggatc

22081
cgggacacgc ctatagtccc agttactcgg gatgctgagg caggaggatc gcttgaactt

22141
gggaggtgga ggttgccgtg agctgagatc gccccactgc actcccgcct gggcaacaga

22201
ataagactcc atctcaaata aataaataaa taaataaata aataaataag ggccatggtt

22261
gtggggtgag gaggggacag agaaggagag aggtttagga ggcagacttg atggtacttt

22321
ggacaggagg atacacagtc acagctcctg gcctgggtgt ctgggtagat ggtgtgccct

22381
ttgctgagag caggtggctg gggagcggat gggcccagcg ctggctgtgc tgtgtgggat

22441
ttgcgagccc tgaggaagag gttttgaggc ttcagatgct cagggaagca ggggatggag

22501
atgtggcatc ttcaactgag gagcaatgtt cactcaggca ctcagcagac gtttacttac

22561
tgcccacaag tcaatcatgg ctgaatagat gaggcagcaa tgagaacagc agcagcatta

22621
cagcagtgac ctgttttttt gatgttccag gccttgtgct aaataaatgt cttgcacaga

22681
atcactctgg gctccccgat ccctcactcc tggtctgcct ccttcctcac gggccactcc

22741
acctcgctct cctttgctga ggccgcctcc tctgcttcac ttttaaatat ctgatgcccc

22801
acatcccagt cctgggcccc ttctgtcttc tccctgcaca cttagctgct tggctttcgg

22861
tactgtctgg gaaaaaccat gactccggag tccacatctc tggccttgat ttctcccctg

22921
aacctgccaa tttatacaac ccagccctct actgcgttaa tcacacctca ggccccacac

22981
tgcactcact gtttcactca tccccccccg cccttttttt tttttttttt tttttttttg

23041
agacagagtt tcactcttgt tgcccaggct ggagtacaat ggcgcagtct cggctcactg

23101
caacctccac ctcccaggtt gaagccattc tcctgcctca ggctcccaag tagctgggat

23161
tacaggcatg caccaccacg cccggctaat tttgtatttt tagtagagac ggggtttctc

23221
catgttggtc aggctggtct cgaactcccg acctcaggtg atccgctgat ccgcctgcct

23281
cggcttccca aagtgctggg attacaggcg tgagtgaccg tgcccggccc actgctacaa

23341
tactattaac taagctacag acgtgatggg attcaccagt ttttctacta atatcctttt

23401
tctgttccag gatccattcc aggatcccac attgccttta gtccctctcc tcatctcctc

23461
cgtctcctcc aatctgtgac aggtttccca tctcttccag tttcccctga aggctggggg

23521
cacagcgatc tgctcacctt tgactttaaa aaaagtctcc ctggatgaac aatgacattg

23581
gccccagagt gcccaggctt gggggctact gcaaccatcc aggagagaaa tagtggtggc

23641
ttggagtagg aagtgggtgt agatgagaga aacaggtgaa tatggaatgt atttatttta

23701
tttttcgtag agatgggggc tcactatgtt gcccaggctg gtctccaact cctgggctca

23761
agcaatcctc ctgcctcagc ctcccgaaat gttggaatta caggtgtgag ccactaccag

23821
gcatgaaacg tattttagaa tgccatggga catcagccac cagcaatttt ttttgttttt

23881
tgttttctga gacagagtct cgctctgtca cccaggctgg agtgcagtgg ccagatctca

23941
gctcactgca acctccacct cccgggttca agcaattctc cagcctctgc ctcccgagta

24001
gctgggatta caggcatgca ctactgcatc cggctaattt tttttttttt tttttgtatt

24061
tttagtagag atggggtttc accgtgttag cagggctggt atcgatctcc tgaccttgtg

24121
atccgcccgc ctcggcctcc caaagtgctg ggattacagg catcagccac tgctcccggc

24181
tgcatccagc taatttttgt atttttagta gagactggtt tcaccatgtt ggccaggctg

24241
gtctcgaact cctgacctca gatgatccac ccgccttggc ctcccaaagt gttagcatta

24301
caggcgtgag ccaccgtgcc tggcaacctt gcaaattttg aattccctgc taggtgctgg

24361
gaactcagac tttcaccaac accagcccag agaggctgga cgaggcagtg gctgcaaagg

24421
gagaggacag gggatcttaa gaaggcgtga agggagggga tctgcatgaa ggcaactgtg

24481
gctacttttt tgtttcgttt tttgttttaa gacaatgtct tgctctgttg cccatgctgg

24541
agggcaatgg cacattcttg gctcactgca acctccacct cctgggctca ggcactcctc

24601
cggcctcagc ctcctaggta gctgggacta caggcacgta ccaccaggcc ctgctaagtt

24661
ttaaaaaact tgtagtagag acagggtctc gccatgttgc ctaggctggt ctggaactcc

24721
tgagctcgag tgatcctccc accttggcct ctcaaagtgc tgggattaca ggtgtaagcc

24781
accacaccca tagttgtggc tcctttaaga tgaggccatg atacccttta ctcttcacct

24841
aaagcagtag ccaagggaca tgtacatagg ggtgctcaac acctgcttgg tgaccgaggg

24901
attgagcggg gtggagggtg acacaccaag gtcatggcaa ctctgtcatg aggctaggag

24961
ttgcaaagag ggtcactact gaggacagtt acattaatcc tttaggccag tgcttctgaa

25021
actataaggt gtacaaatca ccagacagtt ttgttaaatg cagatccaga agcagtgcat

25081
ctgggctggg acctgagatt ctgcatttct ggcaaactcc cagctaccag tttataaaag

25141
gttgtccatc cctgcacctt tcctatcctc atggcagccc taggagaagc ctcagggtag

25201
gaacatttgg atacaaaaaa acaggggctt tctagagctg tcgcacagga aacaggctca

25261
ttagaacctg tctctactaa aaacacaaaa atgagctggg catagtggtg catgcctgta

25321
atcccaacta cttgggaggc tgaggcagga gaatcatttg aacccaggag gcttaggttg

25381
cggtgagccg agatcgcgtc attgcactct agcctgggtg acagaacgag actctgtctc

25441
aaaaaaaaaa aaaaaaaggt cgggcatggt ggctcacgcc tgtaatccca gcactttggg

25501
aggccgaggt gagcggatca cctgaggtca ggagttcgag accagcctgg ccaacatggt

25561
gaaaccccgt ctctactaaa aatacaaaaa ttagctgggc atggtggcgc atgcctgtaa

25621
tcccagctac tcgggaggct gaggcaggag aatggcttga acctgggagg cggaggttgc

25681
catgagccga gatcacgcca ctgcactcca gcctgggcga cagagcgaga ctctgactca

25741
aaaacaaaac aaaacaagaa atggggggaa ttccttggat tctgattgaa ggaaatagaa

25801
ctgggaaggg aagactgtca ggtggctgct gttgggccca cctctccctc cctggggtca

25861
cacaggccat tgtcaacact tctctccaca aatttgcttc ttctctgtct tgtccgtgga

25921
tccccagacc ctgtggcctt ccagttcttg aacccatctc ttgagtgagt cagggtctca

25981
atttcaaatt cttgacctca gcttgagaga ggcatccaag cccttgtcta atcagccttg

26041
gtcagagagg tggagtcact tggtacagac agtgagacct gtaggaggag ggtgtggggt

26101
ttgccctaat cactggtcct aagggacaaa gaaaggtaga atatgagagc tgcctggacc

26161
tctcccctta ccttgagccc ctctcttctc tctccagaca ccggcggtgg gggccggagc

26221
gcaggacagc actgggcaag gctccgggga gaaagcgggt tgtccctgga gcggcaccgg

26281
tcaacactga cccaggcttc ctccatgaca ccacacagtg gacctcgaag caccacgtct

26341
caggcttctc ctgcccaaag ggacactgct caggctgcct ctacacgtga aatccccaga

26401
gcctcctctc cccatcgaat cacccaaagg gacacctcca gggcctcatc cacccaacag

26461
gaaatctcca gggcctcatc cacccaacag gaaacctcca gggcctcatc cacccaagag

26521
gacaccccta gggcctcatc cacccaagag gacaccccca gggcctcatc tacacagtgg

26581
aacaccccca gagcttcctc tccctcacga agcacccaac tggataaccc cagaacctct

26641
tctacccagc aggacaaccc ccaaacttct tttcctactt gtactcccca gcgggaaaac

26701
cccaggacac cctgtgtcca gcaggacgat cccagagcct cctctcccaa cagaaccact

26761
caacgagaga attccagaac atcctgtgcc cagcgggaca atcccaaagc ctccagaacc

26821
tcctctccca atagagccac acgagacaac cccagaacat cctgcgccca gcgggacaat

26881
cccagagcct cctctcccag tagagctaca cgagacaacc ccacaacatc ctgtgcccag

26941
cgggacaatc ccagagcctc cagaacctcc tctcccaata gagccacacg agacaacccc

27001
agaacatcct gtgcccagcg ggacaatccc agagcctcct ctcccagtag agctacacga

27061
gacaacccca caacatcctg tgcccagcgg gacaatccca gagcctccag aacctcctct

27121
cccaatagag ccacacgaga caaccccaga acatcctgcg cccagcggga caatcccaga

27181
gcctcctctc ccaatagagc tgcacgagac aaccccacaa catcctgtgc ccagcgggac

27241
aatcccagag cctccagaac ctcctctccc aatagagcca cacgagacaa ccccagaaca

27301
tcctgtgccc agcgggacaa tcccagagcc tcctctccca atagagctac acgagacaac

27361
cccacaacat cctgtgccca gcgggacaat cccagagcct ccagaacctc ctctcccaat

27421
agagccacac gagataaccc cagaacatcc tgtgcccagc gggacaatcc cagagcctcc

27481
tctcccaaca gaaccaccca acaagacagc cccagaacat cctgtgcccg acgggacgat

27541
cccagagcct cctctcctaa cagaaccatc caacaagaga accccagaac atcctgtgcc

27601
ctacgggaca atcccagagc ctcctctccc agcagaacca tccaacaaga gaaccccaga

27661
acatcctgtg cccaacggga cgatcccaga gcctcctctc ctaacagaac cacccaacaa

27721
gagaacccca gaacatcctg tgcccgacgg gacaatccca gagcctcctc tcgcaacaga

27781
accatccagc gagacaaccc cagaacatcc tgtgcccagc gggacaatcc cagagcctcc

27841
tctcctaaca gaaccatcca acaagagaac ctcagaacat cctgtacccg acaggacaat

27901
cccaggacct cctctcccaa tagagccaca cgagacaacc ccagaacatc ctgtgcccag

27961
cgggacaatc tcagagcctc ctctcccatc agagccaccc aacaggacaa ccccagaact

28021
tgtattcaac agaacatccc cagatcatct tctacccaac aagacaaccc taaaacctct

28081
tgtaccaaac gagataacct cagacccact tgtacacagc gggaccgcac acagtccttt

28141
tcctttcaac gagacaaccc tggaacctcc tcatctcaat gctgcaccca aaaggagaat

28201
ctgagaccat catctcccca ccgctccact caatggaaca atcccaggaa ttcatctccc

28261
catcgtacta acaaagacat cccctgggcc tcgtttcccc tccggccaac tcagagtgat

28321
ggtccccgaa cctcttcccc atctcgctcc aagcaaagcg aggttccctg ggcatccatc

28381
gccctccggc caacccaagg tgacaggcct cagacatcct ctcccagcag gccagcccag

28441
catgacccac cccagtcctc ctttggcccc acccagtaca acttgccatc ccgggccacc

28501
tcttcctccc ataacccagg ccaccagagc acctcccgaa cttcctcacc tgtgtacccc

28561
gctgcctatg gggctcccct gacctctcct gagccctccc agcctccatg tgctgtgtgc

28621
attgggcacc gggatgcccc tcgagcctct tcgccccctc gctatttgca gcacgacccc

28681
ttccccttct tcccagagcc ccgcgcccct gagagtgaac cgccccacca cgagcctccc

28741
tatataccac ctgctgtgtg cattggacac cgagatgccc cccgggcgtc ctcgcccccc

28801
cgccacaccc aatttgaccc cttccccttc ctcccagaca catcagatgc cgagcatcag

28861
tgtcagtccc cccaacacga gccccttcag ctccctgcac ctgtgtgtat tgggtaccga

28921
gatgcacccc gggcctcctc cccaccacgc caggccccag agccttccct cttattccag

28981
gacctcccca gggccagcac agagagcctt gtcccttcca tggactctct gcacgagtgc

29041
ccccacatcc ccacccctgt gtgcattggg caccgggatg caccctcctt ctcatcccca

29101
ccacgccagg ctcctgagcc atccctcttc ttccaggatc cccctggaac tagtatggag

29161
agcctggccc cctccactga ctctctgcat ggctccccag tgctgatccc ccaagtgtgc

29221
atcgggcacc gggatgcacc ccgagcctcc tccccacccc gccacccacc cagtgaccta

29281
gcgttcctgg caccctcacc ttcaccgggc agctctgggg gctcccgggg ctcagcgcct

29341
cccggggaga ccaggcacaa cttggagcgg gaggagtaca ctgtgctggc cgacctgccc

29401
ccacccagga ggctggccca gagacagcca gggccccagg cgcagtgcag cagcgggggc

29461
cgcacccaca gccctggccg tgcagaggtg gagcgcctct tcgggcaaga gcgcaggtga

29521
gcccgggggt ggggtcagcc aggtgggctg gggaggaggc tcggcagcag gacaggtgaa

29581
gggttagggt gccaaaagaa agtgttcaaa tccccctggc ttgccattta ccggctgtgt

29641
gaccttgggc aaatcgctcc atttctctgt ttctgcatat tgggagtttt ctgttttgtg

29701
tgtgtgtgtg gttaagtgat gtcatgcaca gcccagtggt taacagcaaa gactgcagtc

29761
aggagggctg agtccaaatc ctgggtcaaa gccacatgtc aactcgtatg acctgatata

29821
gtgagttaac ctacctgagc ctcagtttcc tcatctgtaa gggaggggaa catgagcaca

29881
ttcattcaaa taagggtgaa ctgtcttttt attttttatt ttttgttttt ttttttgagg

29941
tggagttttg ctcttgttgc ccaggccgga gcgcaatggt gcaatctcgg ctcactgcaa

30001
cctccacctc ctgggttcaa gcgattctcc tgcctcagcc tcccgagtag ctgggattac

30061
aggcacgtgc caccacaccc ggctaatttt tttgtatttt tactagagac ggggtttcgc

30121
catattggcc aggctggtct cgaactcctg acctcaagtg atccacccgc ctcggcctcg

30181
caaagtgcta ggattacagg agtgagccac cgtgcccggc caaaatgaga gtgaactctc

30241
aaaccctttg atccagactc atgggttttt tttttttttc ttccgtgcat gagggagaag

30301
aagaaagtac ccatgatttt ttcctgcctt ggcaaagaaa actcatgggt ccctatgcat

30361
ttcagaaaac agttatgtca atttaaaatg tatggccagg gccgggcacg gtggctcatg

30421
cctgtaatcc cagcacttgg ggaggccgag gcgggcggat cacaaggtca ggagatcgac

30481
agcagcctgg ctaacacggt gaaaccccat ctctactaaa aatacaaaaa attagctggg

30541
catggtggcg ggcgcctgta gtcccagcaa ctcgggaggc tgaggcagga gaattgcttg

30601
aacctgggag gcggagcttg cagtgagccg agatcgtacc actgcactcc aacctgggtg

30661
acagagtgag actccatcta aaaataaaaa taaaataaaa atgtatggcc agagctacct

30721
attttaagaa agaaagctca cagaattatg gatttttagc agtcaaacat cctgggacac

30781
ctgaagtcca ggtgtctttt gagtctcctt ggtcagcagc actggccccc tggaagggga

30841
gcatttcctc ctgatcaggc tgaggtttct ctccccagaa gttccagccc tcgagttttc

30901
aagaatcaga gctagaattc cattagttag ggtcaagaga acaacagcaa caaaaagcag

30961
tctggaagtc tcaaaacttt ccatgtatat aattcaacga atttttagtt tatttaccaa

31021
gttgtccaac cattgccaca atctaacttt agaacatttt catcacccta aagggtatgg

31081
aatattttgt atctaaaatt cctctttgct gctccttggg aaagttttct cctggatttg

31141
aatctgcatg agaaacctta tcagtcttgg ctgggtgcag tggctccctc ctgtaatccc

31201
agcactggag cttgcagtga gccaagatca tgccactaca ctccagcctg ggtgacagag

31261
tgagactccg tctcaaaaaa aaaaaaaaaa aaaaaaatta gccgggcata gtggcacacg

31321
cctgtagtcc cagctactca ggaggctgag gcagcagtat tgcctgaatt tgggaggtgg

31381
agtttgcagt gagctgagat tgcgtcattg cactccagcc tgggcaacaa gagtgaaact

31441
ccatctcaaa aaaagaaaaa aaagaaactt tatctcttgt tcttcaaatt tccttttcca

31501
gtaagcttga tcatttaata tccagatgac aaccgtgtgg tctccagcat tagtataatt

31561
ctttctttgg ccttaaaaac aaaaacccag agcagtttta ggtttacagc aaaattgagc

31621
agaaagtgca gtgttccatg cacagcctct cccactacca atatcctgta ctagataggt

31681
atgcttgttt ccagctcctg gcctcaaggg atcctccttt cttggcctct caaagtgctg

31741
gtgagccact gtactgggca gtagggtgat acatttgtta caatccatga acctacacta

31801
tgaaatcacc caaagtttag ggttcactct tggtgatgta cagcctatag gcttgaatga

31861
atgtatgaca agtatccacc attgtaacat catggagtag tttcaccctg aaagtcttca

31921
gtgtctttaa cttttttttt tgtttggaga tggagtctcg ctctgtcacc caggctggag

31981
tgcagtagtg caatcttggc tcactgcaac ctctgccttc tgggttcaag cagttctcct

32041
gcctcagcct cccgaggagc tgggactaca ggagcatgcc gccacatccg gctaattttt

32101
ttgtattttt agtagcgaca gggtttcacc ctgttgccca ggctagtctt gaactcctga

32161
gctcaggcaa tctacccacc tcggcctccc aaagtgctgg gattataggc gtgagccacc

32221
gtgcctggtc tgaccttttt tttttttgaa acagggtctt gctttgtcac ccagcagtag

32281
tgcagtggcg tgatcatggc tcactgcggc ctcaaactgc caggctcaag cgattctctc

32341
acctcagcct cctcagtagc tgggactaca ggcgtgtacc actataccca gctaattttt

32401
ctactttttg tagagatgga gtctcacttt gttgcccagg ttggtctcaa actcctggcc

32461
tcaagcaatg ctcccacctt ggcctcccaa agtgtctttg acctttttat gattactatt

32521
tcttgtctaa tgtcaatttt cctaactttg tcttaactaa taactcagca gggacattaa

32581
ggtctttaag ccaaagttaa ttaattttct ttcctttttt ccaggataat ttcagagaga

32641
taaggtgttt atattaataa tagaaatgag aaatatgttt acacttttat taaccatttg

32701
tttttacacg atcactccta tacatttaat tctactctct ttgaaatagc ttatttacct

32761
tttagggaag ttttcataat tttactgaat aattaaaatt tttcctctta tctggcacct

32821
tttccaagta gaaaaccatt catcctctga atatggaaaa ttttaaaact gtgcagtgtg

32881
tgtgtaaggg acagactgga gcttatgagc gggtggctgt aggagtgtgc ttttattttc

32941
tcctatttcc tcatcgatat gtatttattg agcatctact ctgtccaagc attgtcccga

33001
gtctggaaaa tttttcttaa agggttgtca catcaaagca ttgggagttt tggcttgatc

33061
ttaatttttt tttccttaga tgcctttggc atctcttaga gtcacgtagc atcctgtggt

33121
catttgaatt caaaacctag ccttcactgg atttgctaga cttgatggct ttgctccttt

33181
aattctctct ggaggtcgaa gaacccatct aagcttccga aggaaacgtt tcctttgtca

33241
tgcttggtgc ggccacatca accctcggga acaggtggcc ccgaggagac gctgttgctt

33301
cagcatcgga caagccaggt ctctgttggg gtttcagaat cttcttgagt ccctcactct

33361
tttctctcag ttctacatgg gggaaaaaag gaaggcgagt tctcaggagg aatgctcatc

33421
aagcaagctg gagttcgtat ggaaaatgca tccatccgga agagaacaca caagtgcctt

33481
gcttccctgc accgggtgtt tccactattg tcctcctggt cctccccatt agggaggaac

33541
agcccactgg gtcacgtctg ggctcttgct tcatcgaagc tcctataccc cagttcgggg

33601
gaaaattcac tctaaggcct tcagctctca cagagtaagg aaacgcactc acctccaatt

33661
agattacaaa ttggctgggt gcagtggctc atgcttgtaa tgccaagact ttgggaggtc

33721
aaggcaggtg gattacctga ggtcaggagt tcaaaatgag accagcctgg ccaacatggt

33781
gaaaccccgt ctctactaaa aatataaaaa ttagctgggc atggtggtgg acacctgtaa

33841
tcccagctgc tcagcaggct gaggcaggaa aatcacttaa aaccagaagg cggaggttgc

33901
agtgagctga gattgcacca ctgcactcca gcctgggtga cagagcgaga ctccatctca

33961
aaaaaaaaaa aaaaaaaaaa gttacaaaca gcctgcccag ggagccctca agctcagaaa

34021
cacttcctcc agggaacttt ggttcctctc cgaaccagct gccaataact gctaacaact

34081
aacattattg tgctttatgg ctctgattct aatgacattg gcaaaagaca tgaaacaaca

34141
aaaaactcca accccatact ttttttttga gacaggatct tgctctttca cccaggctgg

34201
aatgcagtgg catgatcatg gctcactgca gcctcaacct cccaggctga agcgatcctc

34261
ccacctcagc ttcccaagta gctgggacta cagccacgta ccaccatgct cggctcatta

34321
aaaaaatttt tttttcctag aacaaggtct cattctgttg ccagggctgt ctcaaactcc

34381
tcgactcaag tgatcctctg acctcagcct ccccaagtgc tggaattaca ggtgtaaaga

34441
cactgtacct ggcctcccaa ccccatatat atatatatat attttttgag acagggtctc

34501
actatgtcac ccaggctgga gtgcagtggc gcgatctcag ctcactgcaa cctccacctc

34561
ctggggtcaa gcgatcctcc tgcctcagcc tcctgagtag ctgggattac aggcacgtgc

34621
caccacgcct ggctaagttt tgtattttta gtagagattg ggtttcacta tgttgaccag

34681
gctggtctcg aactcctgac ctcaagtgat ccacccacct cagcctccca aagtgctgtg

34741
attagaggca tgagccacca cacctgggct aatttttgta tttttagaga ctaggtttca

34801
ctatgttgtc taggctggtc ttgaactcct gagctcaagc catccgcctg cctcagcctc

34861
ccaaagttct gggattacag gcgtgaccca ttgcgccctg cccaatccca tacttttgaa

34921
ggtgtcgttc cagcatggct cctcaggcac aggcccacca cagacagcag ggcctatgga

34981
ggcctgagca gagtttcctc atacttccct ttttgctgcc tcactctggg tccaccacag

35041
ggtggccttt ttcaggcttc tcttcctggt tcagttcatc gaccaaagac atggctccat

35101
ttgctaactg agacccaacc aaaataaaca ttcatggagt ggttgggcct tttgttgtga

35161
ccccttaggt agaggaaggg agagatatgc ccaggttctg tttggtgttt ctacctgtca

35221
atagagatac cacgttaatc attaacagcc atgcctccca gttagtaagc aagacaacta

35281
actggaacta gactttttac acaagttaga gatgatcttc atcggatgcg tcaacaatgc

35341
ctgaagccca gtgtcttaga aacaacactt gcccagggtc aggcgtggtg gctcatgcct

35401
gtaatcccag ctacttggga gattaaggca gagaatcact tgaacccggg agatggaagt

35461
tgcagtgagc cgagatcgcg ccactgcact ccagcctggg tgacagagcg agactccatc

35521
tcaaaaaaaa aaaaaaaaaa aagacacttg cttggacagt ttatgttggc ctctctgaag

35581
ttgtcaggga gaatgtttct ttcttctgat cttgctcaga gctcttttgc caacagctag

35641
gatggcctgg agttttcaag gctaagcgct gggattctgt tggttaacag tgatgggagg

35701
gaaaaaggaa aagaaatcca aaatttacaa tatggacagg aaaaggcaga aagaatggaa

35761
cacgggggca cacagcagtc tggctctgtc gtcccacctc gtgggctgcg atcatgatac

35821
aagtgcttgg cccctggaac ataagaagca ctcaataaat gctttgtcat aatgattatg

35881
tgtgcccagt gcctggtaca cagtaggtgc tcaataaatc ttaattcccg caaagaccag

35941
tctaaccttt gtctgggggt ggctcttggg ctgctggtgg ggtggtggtt agtcatagga

36001
agtactggat gagacaggag agggccatgg ccagggccag atccccctcc ccacccaacc

36061
gcctctactc cccacttttc tcgtcatgtt cgcaagagcc tcatgaggca gaatagagca

36121
gtgttaacca tccccatttt tcagaagggg aaactaaggc cctgagagtc atcctcactt

36181
agggcccttc aacgagcttg cagtgggtcc ctggctgtcc cacatctcct cctgttggag

36241
gtgggagcag aggggctggg gtgctgggag tgggacagtc cctcagagga gtggctgcat

36301
ttgctcatag gaagtccgag gcagcggggg ccttccaggc ccaggacgag ggacggtcac

36361
agcagcccag ccaaggccag agccaacttc tccgaagaca gtccagccct gcccccagca

36421
ggcaggtgag cactgccagc tgtctggggc cccgcacccc aaggggcggc cactgcctct

36481
tccctcccgc tagaagccag gcagggggct tggacaggaa ggtcctctat gaaagggtcg

36541
gagtccaatc atggggatcc agctctcccc tctccccaac ggccagcagc tcttggcaaa

36601
atgcacaaga ccccacatta atcctttgaa gatagcccct ctcccacgct atccccttcc

36661
tttactaagc actgctgtct tttttttttt tttttttttt tgagatggag tcttgcactg

36721
tctcccaggc tggagtgcag tgggacaata ttggctcact gcaacctctg cctcccaggt

36781
tcaagtgatt cttctacctc agcctcccaa atagctggga ttacaggcgt gtgccaccac

36841
acccaactaa ttttcgtact tttagtagag acagggtttc accatgttgg ccaggctggt

36901
cactcctgac gtcaagtgat ccgcccacct tggcctccca aggtgctggg attacaggcg

36961
tgaaccacgg cacctggcca atactgctgt cttgagcaga tttcagggaa agccttgaag

37021
caagaatctg gctctaaggg ccctctcttt cagggtaatt tgtatcttta accaaaccca

37081
gagggctagg cccgcctcag tggaatgggg tattggtggt ggaggttctg gcacctgata

37141
gcccaagttg gaatcagtat ctttgagagg ggtgagaagc caagaacggg ggcaggtctt

37201
tgcagatctt tttctggaac tgaggaaagc gggtgaaagg gaggagctga ccccggaggg

37261
gtggggcaga gaccctgtgt actttttggc ctgctttgat tcaggctgct gtgtggacac

37321
agccttgact ctctgggggc ctaagaaagg cagagctggc agccaggtcc ccagagagag

37381
agcctcacct accccctcac ctcatcccca ggtgaccatg ctccctgcca aacaggcaga

37441
actgacccgg cggagccaag cagagccccc tcatccttgg agtcctgaga agagacctga

37501
gggagatcgg cagctccagg ggtccccgct gccccccagg acatcagcca ggacccctga

37561
gagggagctg cggacacaga gacctctgga gagtggccaa gcaggcccaa gacagcctct

37621
gggggtgtgg cagagtcagg aggaaccgcc agggtcccag ggccctcata gacacctaga

37681
aaggagctgg agcagccagg agggaggcct gggccctggg ggctggtggg gatgtggaga

37741
gcccagcctg ggggcagcca aagccccgga gggagcatgg gggggcactt ccagggagta

37801
caaggagagc tgggggcagc cagaggcctg ggaggagaag cccactcatg agctccccag

37861
agaactagga aagagaagcc cactcacgag cccccctgag aactggggag gccccgcaga

37921
gtcctcacaa tcctggcact ctgggacacc cactgctgtg ggctgggggg cagagggagc

37981
gtgtccatac ccgcgtggct ctgagaggcg acccgagctt gactggaggg atctgcttgg

38041
ccttctccgg gcaccaggag agggggtctg ggcccgtgtc cccagcctgg actgggaggg

38101
cctcttggag ctcctgcagg ccaggctgcc ccgcaaggac ccagctggac acagggatga

38161
cctggccagg gctttagggc cagagctggg tcccccaggc acaaacgatg tccctgagca

38221
ggagtcacac agccagccag aaggctgggc cgaggccacc ccagtcaatg gacacagccc

38281
cgcactgcag tcccagagcc cggtccagct gcccagccct gcctgcacct ccacccagtg

38341
gccaaagatc aaagtgacaa gaggaccagc gaccgcaact ctggcaggcc tggagcagac

38401
gggccccctg gggagcagga gcactgcgaa gggccccagc ttgccagagc tgcaggtaag

38461
gaggtttcca ccctcccaag ggtagccaga aagtcagccc cactcagcca agtctccttg

38521
gaaaagcctc cccttggagt agcctaagct cctgcatccc cctccaggct cagacctcag

38581
cctccctgct gaccacaacc catcccgatc accaaactgg cccaacaatg atgatgagca

38641
acacagtttt aagcgtttat gggccaagcc ctgatctgaa tgtttgacgt gtgcttttcc

38701
catttagtct ccttagcaac caggtgagaa atacactatt tacagataag gaaactgatg

38761
cgcagggtga agccacttgc tggtggggca tgggcaaaac ccaggtctgc tcagtgcaga

38821
ccacactgag gcctcaagca agatgctctg gccagggcct attcccctcc tggctccacc

38881
atacctggtt tatgttgtgt ctggtggcac acacctgacc ccacctggga ctgtagccag

38941
tgtgggcatg ccccttcccc tggtggtact caggtacctg agtccaggac agcctcgctt

39001
accctctctg gcccctacag ctcctctcag acacagagaa gagggtgcat caatgctcac

39061
tgggttcagc tagctgccaa gacaggctgc ttaaatgagg gtcgtgtgca aagtgggccc

39121
agcgccgggc acacagtagg tgctcgccct tcccctgctt cactggtgct ttggtgctgc

39181
cttgaagccc agaacattct tcatctgaag atggtgggca gggagggtct tggaggccag

39241
aatcctgcac cctggcaata gctcattggg aggacggcat gtggttttga acaccagcct

39301
ctctctctct ctgtaagatg gaccaaccac ttctctgacg ggcagcgctg gggtgccgtg

39361
ggggttcctg cttgtttctc caaagcctcc tcatctccta gatgcaaagt ccaacgccac

39421
ctgccccagg atgagcaggg cttccaggca tcagggtgca ccccgtgctg ggcccagggc

39481
cttgccatat gtgcctcaag tggataggag gcagctgcca cttgacagat ggggaaactg

39541
aggctcagac tccttaggca tttgctgggg gtcacacatg cataggtcgt gagaaatgag

39601
atcaaagcat ccactccaaa gtttgtgctt ttatttttat ttatttattt acttattgag

39661
acggagtttc gctcttgttg cccagactgg agtgcaattg cacaatctca gctcactgca

39721
acctccgccc cccaggttca agctattctc ctgcctcagc ctcccgagta gctgggatta

39781
caggcatgtg ccaccatgcc cggctaattt tgtgttttta gtagagatgg ggtttctcca

39841
tgttggtcag gctggtcttg gactcctgac ttcaggtgat gcatccacct tggcctccca

39901
aagtgccggg attacaggtg cgagccacca tgcccggcct aagtctgtgc ttttagccac

39961
cacgtcacaa agctcctgag cccatgggag gactggagaa ccctctcccc tgtatttccc

40021
tgtggctttg atgagttgac cctccaatca actcaatgcg tggacatcag agaagcaggg

40081
ataagtcagc tcgtcctgcc ctcagattgc tgtcaggctt gttaggaagg cacacagaca

40141
gctcaaggag gacacggtgc tgtgtcccgg ggcatgctgg gtgccacagg ccggccaggt

40201
caagaaggaa gttagaaaga ttcttcagtt tcatggtgaa gctcagggtt ctcaggaggc

40261
taggagatgg tggctgggaa gggatgggag caccatgtac tgaaaggaat ttcacagatg

40321
acaaaacgag taaccaccag gtcctgctgg ggctccagct gctcctctct atgaaaatcc

40381
ttggcttggc acagctgggt gcagtggctc acatctgtaa tcccagcact ttgggaggct

40441
gaggcaggca aatcacgagc tcaggagatc gacaccagcc tggctaacac ggtggaaccc

40501
cgtctctact aaaaatacaa aaaattagcc gggcgtggtg gcgggtgcct gtagtcccag

40561
ctacttggga ggctaagaca ggagaatggt gtgaacccgg gaggtggaag ttgcagtgag

40621
ccgagatcac gccactgcac tccagcctgg gtgacagagc gagactccat ctcaaaaaaa

40681
aaaaaaaaaa aaatccttgg catggcactc aaggccggct tcccttcctt ccactccgga

40741
tttgcctcat tggtgctgag ctggctgcag ggcctgtgag cacatatccc tgcctttgca

40801
catgctcttc cctgttcagc caccaaacgc ctgttcattg tcgaagtctt aggtcaggct

40861
ccctgtcctg agaagccttc cctgaacagt cactcctagt aatggtcccc ttctgggctt

40921
ggcagttttg cttccatttg tccatgcaac atccatctaa tagggttgtc atttccccat

40981
aagctccaca caggcaggat ctctacctgc tttatctctg taactctagc tctggcccag

41041
ggcctgacat aaaggagggg acagctcagt ggatgcatgc aagatggagg acacaggggt

41101
cagtgggtga acaatgaatg aatggagggt gaatgtgtga atggatgatg gatcaatgat

41161
gcatgttgaa tgaataatag acatcttttg gatggatgac agatgggtga tgatggatgg

41221
atagctgggt gatgaatata tggtggtggt ggatatatga tggatgttgc ttaggtgatg

41281
gatggatgaa ctttgggtgg aatatgaatg gatagatgtg gcatgggtgg atgaatgtca

41341
gatgatagat gttggagata tgggtagatg gatgatggat ggagagaggg atatgtaggt

41401
attgggtaaa tggatatgtg atggatcaat ggagggtaga tacatgaatg ggtgatagac

41461
aatggatgat gggtacatga gagggtgagt catgtgatag acactggatg gttggatgga

41521
tacatggatc tactgatgct ggacgttaga tgggtgttgc atggacagat gatagaatgg

41581
atggatgagg tggacagatg catgcatcct ggagaataag ttgggctaag ctgtgttctt

41641
tttttaatct ccagttccaa ccagaggagc ctgaggagtc agaaccaagc agaggccaag

41701
accccctgac tgaccagaag caggcagact cggtagctgg gtcatgggtg tgggtacata

41761
cggtggggaa gggaggggga agcaggttgg agatgggctt cattcctcag aagagcccta

41821
gaatcaacca gaccaaagtt ggcattgcca tggggtcatc tatgtgcatg gtggggcctt

41881
aagaagaggg gctctgcagg agccaccttc tggcttgggg acctgggtag gtgggcgatc

41941
ctggggtcag aaccctaggc catgcttctc atttgctggg actgaaaagg tcaatgtctt

42001
tccctgcgca aatgatggtt tggccccagt ggtctctgtg ggaagagatc cttccggttt

42061
gaaagggcca ggccaggctg aaagagcagg gcttccacga gcaggagcca gagagctgag

42121
gatgtaccca gtcagccagg cctggagggt ctccagggtc ctggaggcgg gagagatatg

42181
tgcgggggtg ggacccacgg atgctgctct gaggcctggc tgcagctggt gagcacaact

42241
ctgcccgccc ctccccgtga cctaccaaac agactgttct cgtcaccctc agcctccaga

42301
gaggtgagat cagagttgag ggccgtgggg cagtgggagg tgggggagga ggagacagac

42361
tgtttggggc tgtgttttcc ggtcctgctc ttcctcccgt tgcctcctga agccaggggt

42421
ggcagggagc gtccattggg cagcatagcg ccccccaagt agggccctgc cgtgagtcaa

42481
agctggggga attctgccca aaccctcact gtgcagatga ggaaatggag gcaggggagt

42541
cgtcccaggt tatacagtca gtggctagct ggactgggac tagaacccag ggcccaggaa

42601
ccacccagcg ctctctctgc acctccacct ggcacccatg ctgcccccgt ccctgccccg

42661
atttcttgcg tggcttcgaa cggcagtgct gtaacttcga gcagtccagt cttcccatct

42721
gtggaatggg cggggacagg ggacactggt cgctaaaggc gctgccagcc ctcccaggga

42781
ctctgacaac tttgctcttc ctctttctgg gttatttctt catatcctgg agccagagta

42841
gtgaacgagg cggaaacagc aatgccgggg tgcccctcta gtctccatga aacgggcccg

42901
gcccatcaac gtggaaaata tctcaaccta cccccacccc taggcagcct tgactggtca

42961
gaactgataa ccacctcatt catgcattct ttcacacaca cttagtgagc accttctgta

43021
tacccaggtg tgggtcacag gtgagtcgga gcgccatcaa agagttcagt ctagtgagat

43081
ggttgcatgc ctgtggtcag gactgtgatg gggaatgtgg tagcagggtc gggggcaccc

43141
ctacccccaa agccctcctg gacctgtgct ttgatgcttc aagttccact tccaaagagt

43201
ctgcagattc cagagcgagg accctgggct ctctcctacc ttcccagtaa cccatgtgtg

43261
gctttggaca agtgcctctg cttcacaggg gccttggttt ccccaacgag gatgactcca

43321
aagagggagc atttgggggc tctgctagga atgtgtgtag aagtccacaa ctcattccct

43381
ttgcttaagc tggggtcaca aacctaacgc cctgaaggcc aggcaggtaa caatggtgag

43441
aaggtggggg ggcaccgagg gcacttgtgt gactcctcgg ttccagatag ctgttgccat

43501
ggggaagacg ggcccagagt ttccacatct ttcgatattt caagaaacac tggagatatg

43561
tatttatatg tgaaatctct aacctaatgt gaaatactct gaaaacacta tgtgggcaga

43621
aacatacctg tggtctgcac cccctccagc tggcgcccgt ggtttgactt tagggtgatg

43681
acgtgcacac cttcaaaggt gctgagccct gggagccttg tcagtccaac acgatgtagt

43741
gtgaacaagt taaccagctc gtctcggcag ttctgggagg agagaaagat gggaaccctg

43801
gggctccatg gtggggggca ccacagaatg ggcaggggag gctgtagcca ggggtgcccc

43861
catcctgcca aagggacctg gggccaacac tggaccctgt ttgacaggca gacaagaggc

43921
cagcagaggg caaggctggg agcccgctca agggccgact ggtgacctca tggcggatgc

43981
ccggggaccg gcccacgctg ttcaatccgt tcctgctgtc tctgggggtc ctcaggtggc

44041
gaagggtagg ctggctccag tggggactgg aggggtgagg gtggatagag acggggatgg

44101
gagggaggag ggggctgtta agcaaaggag agagagtggg ggctgaggag gaggcaccta

44161
gggccgtcgc atgacaggag aggtgggagc agagctctta agctcatcct ggtctcagca

44221
agcgagtggg tttcccactt ccggggcagg cttgggggct gctttcagct tttggagtga

44281
ggggtgatgg aataatctac acagctgaaa gcttccaatc agcagcctct cgccagccct

44341
gggccaacgg ggagccaggt atgggggaag ggaaggcgag cttataagtg gctctgggat

44401
tgcaaagtgt gtctcagacc tgggcctgag ccagtttcac aaacatctgg cgttacgtaa

44461
cccatcccct gcccagagag gcctggaaac actcaagcct ctggctgggt tttccacaag

44521
ggcaggcagc tgagacccgc tccctcccac ccgcttcaca gcaggacaga aggggcctgg

44581
ccatctccag cagccacagg ctggctcatg gggtctcttc tctctttgag aggctgactc

44641
tcttactcac cgctgttggc tctgagtcca gcactaggct gggcacctca gagacagtgt

44701
gcccatttta cagatgaagg gactgaggcc cagggaggtg agctgacttg cctgaggtcg

44761
cacagcttgg ggtataaagg agctgatttt cctcattctc agatgagaga agggttgtag

44821
ccaaacttac tgagcctcgg ttgccacatc tgtctattag gaaaaagtct gtggagactc

44881
agggctgcag agagggctca gggagatcag gatgcatgga ggttgcgggg ctgttgtcga

44941
aacactaact ttcccatcca cttcagaatt tccttttttt aaaaaattaa gacggagtct

45001
cgctctatcg cccaggctgg agtgcagtgg caccatctct actcactgca acctctgcct

45061
cccgggtcca agtgattctc ctgcctcagc ctccagagta gctggaatta taggcgtgcg

45121
ccactgcacc cggctaattt tttgtatttt tagtacagac agggtttcac catgttggcc

45181
aggctggtct tgaactcccg acctcaggta atccgcccac cttgacctcc aaagtgctag

45241
gattattggt gtgagccacc acgccaggcg tttttttttt ttttttttta aattaagata

45301
gagtctcgtt ctacccccag actggagtgc agtggcacca tctcggctca ctgcaacctc

45361
tgcctcccag gttcaagcga ttctgccatc tcagcctccc gagtatgtgg tactacaggc

45421
gtgtgccacc acacctggct aatttttata tttttagtag agatggggtt tcaccacgtt

45481
ggccaggctg gtttccaact cctgacttca agtgatccgc ccgccctggc ctcccaaagt

45541
gctgggatta caggcgtgag tcacccagct gagcccagaa tttcctttcg ctgctctttg

45601
tggttaaggc accgagggtg agcaggcaag catggttatc tgagtagtgt ggtaccttta

45661
agccatgggc aggaattacc ttgtctaact aaaggtcacc aacacacagc acgtctggca

45721
ggagggggca ggtaagtcct tggtagagcg aaggaggagc gaagcaggga aagcactctg

45781
gggtaatgat gctggctaac cagcacttat tgtatgccta ctacatgccc agctctgtgt

45841
tcactgcatg gcgccaccta attgcatttg atccacactc ccaggtgcag ttagacgcct

45901
actgtccatt ttacagatga tgaagtgaag ctcagagagg gagggtcact tgctccaggt

45961
cacacaggga gcaaggggca gaactgagat tcagaccctg ctctggctga cctcagagcc

46021
cagtgcttcc aacacgcccc ctacaccact gccttcacat cctgatctct ctgagccctc

46081
ctgcagctct gggagtcccc acagattttc cccattagaa agatgcggca accgaggctt

46141
ggtgaggttg gctacagtgg ttctctcatg tgggagtgag ggaaatgaag agctagggat

46201
ggaactgcca gcagggcctc ccagttacac agagcagatt taaacttctc ttgggctgaa

46261
gcagtgaaat tagcccaagg ccaagagcca gaaagcctgg agtcgagttc tggcttggca

46321
cctaacttgt gtgcccttct ctgagcctta ccttattatt ctcagtagag taacggtttg

46381
agactggata acctcgaagt ttggtagctc tggtctttgc cagtttaata actcacccct

46441
gggtccctga ggctgtgctg tctctgacct gccaggatga gttgtggttt cttcattggt

46501
gcattcattc attcgagccg tgcttacgga ggatgtgctg tgggcttagg ccctaggctg

46561
gtttccaaga tgtagacaaa aaacattcca gccctggcca ctggagccca gttaggtaag

46621
gacactgaca tgtaactgat gagaacagtg tggtcaccac tttagtgggg aaaggtacag

46681
atgtagggag cactgggcca gcagttccta agtctgctgg ggacactttg gcttcctttg

46741
gtctgagact tcaaggaaga aattttccag gccaacaagc attgggaggg ggaaggggag

46801
aaagagagag agaatgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgct

46861
gggtgtgtgt gagtgtgtgc tgggtgtgtg tgtgtgtgtg tgctggggta cagaagacag

46921
gaagagaagt gttccaggca cagcagagaa ccatcagggg gtagaaggac ctgtcttatc

46981
ctgggaattc ctagtagtcc agtgctgtgt atcttttttt tttttttttt ttctgagatg

47041
gagtctcgct ctgttgccta ggctggagtg gaatgcagtg gtgtgatctt cactcaccgc

47101
aacctacgcc tcccaggttc cagcgattct cctgcctcag cctcccaagt agctgggatc

47161
acagccatgt gccaccacgc ccggctaatt ttttgtattt ttaccagaga cggggtttca

47221
ccatgttggc cagcctagtc tcgaactcct gacctcaggt gatccacccg cctcggcctc

47281
ctaaagtgct gagattacag gcataaacca ccgcgcccag cctccagtgc tgtgcatctc

47341
tttatttact tattgtattt tgcaaaattg accaaagtat gtgtctctcc agcctgtcaa

47401
atgagaatct ggaaggccag gatgacaggc aggagccagg ttgtgatggt tcctgactgc

47461
ctagaagagg aatgtagcac tgatctgtca gcattggtga tgtgtggaag aactttgagc

47521
agggaagtgg tctggtcact gtgttgcggg tactaggagg agtcgcaggg gccagaaaag

47581
cctggaggag gctggtgctg ttaggtgccc agggcactgg accaggaccc tggtggtagg

47641
tgaggtctcc tgcgtgttca ttcactctcc caaggactga ctgcctgagt gaggtgcaag

47701
ggtagggtga gaaaactcag cccggggtgc cagaaggcca gtttctagag ttagatggac

47761
ttaaccttgg cctcattcct catggtggag agactcctgg cagcaaatgc tgggaaagaa

47821
cttcagctcc ctgggcctcc atttctttat ctgcaaaatg ggaacagtaa ttataaaagc

47881
aataattttt ttttttgaga gggagtctcg ctccgtctcc caaggtggag tgcagtggca

47941
caatctctgc tcactgtaac ctctgcctcc cgggttcaag cgattctcct gcctcagcct

48001
tttacatagc tggattacag gcgcctgaca ccacgcccgg ctaatttttg tatttttagt

48061
agagacgggg tttcaccatg ttggccagtc tgctcttgaa ctcctgatct caatgatcca

48121
cccacctcag cctcccaaag tgttgggatt acagacctga accaccgcgc ccggcaaggg

48181
caataatttt tgaaccccaa atcaagatga cagaataatt gaaatgccaa ttattccaag

48241
cttccctgcc tccttgccta aggatagcta atgagggata aagaggttgt cctaggtgcc

48301
ttacttgaat taacacttaa tccttccagc aacctcatga ggtaacagca ttaccccatt

48361
ttacagagag tgaaattgag caccgagagg tgccttgctt aaggtaacac taggctggaa

48421
tccccgtgcc acacgaactt cctagtgcat ttagcaacca attccaccac ggtccctact

48481
cacctgcagg aaaagagcat ctaacaaacg gcccagcgtt ctgggaacct gagcaacggg

48541
tgcacgccca cacctgaaaa accccaaacc aaaaaagacc catttgtgag gagtgggcat

48601
ttgggagaga ccctgccatc caagaactca ctttgtgtcc agcttactcg ctaggaattc

48661
cgcctcttcc tgtgtgacct cgggcaaatc ggctcacccc tctgagcctc cgttttctca

48721
ttagcaaaat aagacctccc tcccaagtct gtggtgagga cgaaaatcga ctcttggcga

48781
gtgggacccg ctgagtcgtt agtactgggt gctttgcccc ggtccccgcc aaatcacggc

48841
gccgagccct agcggaccca tcgctccggg gccgggtcgg gaagcgcagc ctgggcgagt

48901
cgtgcccacg cccggccgcc cgcatcctcc gcccccgcgc cattgccgga gtcacctgca

48961
ccctgggccc ttccttcctc ccagcgcgcc cgcggcccgg gcccgcccgc cctccggccg

49021
ccaccgccct cccttccctg cggccccatc cgcccacccc gccgtcccgc cgtcccgccg

49081
ccccgccgcc ctagcgcgcc cgtcccgttg cggcaggtcc cgcccccggc ccgtctcgcg

49141
cttccattgg cccgccgcgg cccccgccgc tgtttgtctc ggcttccccg ccacccattg

49201
gcccgctcgg gtcctcccag gaagtttgaa aaaaaaaaaa aaaaagtttt atgggcggat

49261
ggaaggggcc ggggcagcgt cggggaaagg aagggccgga ggcgcggcgg cgggcggccg

49321
agaggggcgg cggcggcggc ggcggcgggg ttcccgcgcc gcggagcccg gcccgagagc

49381
cgcgtccacg ttcctgcctc ctgctcccgc cgccctgggg cgccgccatg acggtgagtg

49441
ccccagtcag ccgcccgcgc ccgaggccgg gagaagggcg acgacccgag gcagagccca

49501
gcctctcccc tccggggcag ccccctcctc atttcccgaa ggcgagagga gggctgggcc

49561
ggaagacggg gccacctccg aagcgctttc ggccagaccg gcctcaccct tcccgcaggc

49621
tcctcctcgc cttccctcgc ccactcgccc ccgggagccc aggcgaccct gaggggacgg

49681
aacgacccgt ctcgggcgcc ccctcctcac acttgcggca ccagtcacgg gtggattcgg

49741
ggcgaccctt tcccacctcc cctccagccc cctagacgaa gacccgattc cccaaggcgg

49801
ccaggggccc cagggaggag cggaggtggg cctgggctgg ggaggggcgc tcgtgggtgc

49861
ggatgggtcg cgctgacccg ggcctgggca agccagccct ccgtgtggcc gctggcccga

49921
ggtcgggtgg gcgagaagtg gccggaccgc cccacccaca gcccgggagg cagtcccggg

49981
acgtctgaag cagcgggata ccacgtcttc ctgggcttgc actttgcagc ggtcctgggg

50041
ccttgggaca agcctgcgag tctgagtagg gggcatgatg gcaggggttt gcctttctca

50101
tgggggtgag ctgtacccaa gccccatcaa ttacctgtgc catagttagc atattgagcc

50161
tcacagctgg gttcgctgga ctccccactt cacagccaga taaactgagg cttggggagg

50221
ggcgctggtg agttgcccga ggtcacccca agtataagag aaggagtagc tcctttccct

50281
gtccttctgg cccactgacc gtgatgttcg ggaagggagg ggtggggctg cttttggttt

50341
ctggctagtg cttcagggag gctctgacag cccagtggcc ctcctggggg aggatgagca

50401
gggtgtgtgt gtgcacaggc ggcagtaggc ctctttcagg ggagtggaga ccctgcggag

50461
gagtgggtgg gctgctgggg gcgggctggg ctgctggggg gcgtggcacg cctagcccct

50521
gccctgtgag tgtgatggcc tggacttcct cggcgtcctc ctggacatcc tgccacctcc

50581
ctgctggccc ttcctgtcgt cagcagcctc cccttttctg tcaggagcag aagggatgtg

50641
gggggaggag ctgagtcagt gtcctggggc caggaggaga gaagttgcct tgcccaccgg

50701
gtgcctgccc ggccctcagc cgggtgcttt cacgttacca gatttgatcc ttgaaggttg

50761
gtagtaacat cttaatcaaa cagatgagga aaccaaggtg tggcgaggtg aagtgtcatg

50821
ccccaggtaa ctcagtgagt cccaggctaa gccagaattt gtatccaggt ccgttccagc

50881
tttctttcac agttgcctgt cctgggggca gcacgtgctg agcaagggta aggctgccgg

50941
aagcagcgtg tggggtgctt ggaagatgga cagcacatcc ctgctggtgg cagcagcctt

51001
cctgagggag gtgtcctcct gtgattatag ggccttgtca ggtggagatg gactagcgag

51061
gagacagcag tgtggacaga aacgggtggt catgtttgag aagtagcaag agcgtaggga

51121
aggggtctgg ggaggagggc ctcactgcta gggcttggac aggggcaata gagagccatg

51181
aaagctttta gagcagagag gaggctatga tcaccattaa tagtgttcat tgagttcatc

51241
ctggctgcca tgcagacctc agcctgctct cagctggtgc tcctcctgta cccacctcac

51301
accctcctcc cctggccccc gtgccctgaa tcagggatcc atacagagca agtggcacag

51361
gtgtgtgagt gtgtgaggct ccggggcttc agggagttgg gattctcttc cacccctttt

51421
gcctttgcct gggtgcagct ttgctcccgg atcagccttc cccctcgcct gctgggcatc

51481
aaattatatt tggtcccttg tttactgtct ctttcctaca gtccaccagg gcaggggcca

51541
cagctcttgg tcacagctaa tttcctggcc tagaacagtg cctgataact ttaaaaaaaa

51601
attttttttt ctgcaaacac tccctgagcc cctatctgtg ctgggtcctg gcaggtaaac

51661
agtgtatgtc cctgactgtg agttgcatct aatctagcct gtgaaggata agtaaagggc

51721
ctcaagatag tcacggatgc aacagaggcc tctgagaggg gccatgggag ggcaggacgg

51781
gggcggctgg tggtgcggtg agtggcatga actgtgaagg gacctcagag gtggccatta

51841
agctgggtct taaggcctga gtagccgctt gcctagtcat cggaggagga ggaagcatag

51901
tgtttcaggc caaggacatg gcacatatga agggcccgga gtcctggtgt gttgtgatcg

51961
gcaaggaata tgcagtggta taaacagggg cccctcagca aggggaggcc aggctggaag

52021
agtgtgatga ggcttccctg ccatcctgag gcagctggac tttgttttaa agccacctgg

52081
agaccgggtg tagtggctta tgtgtgcctg taatcccagc attttgggag gctgaggtgg

52141
atggatcact tgaggtcagg agttcgagac cagcctggcc agcatggtga aatcccatct

52201
ctactaaaaa taaaaaaatt tgctggacat ggtggtgggt gcttgtaatc tcaggtattt

52261
gggaggctga ggcaggagaa acgcttcaac ccgggaggtg gaggttgcag taagccgaga

52321
tggcgccatt gcactccagc ctgggcagca gagactctgt ctcaaaaata aagcaagcca

52381
cctggagccg tccctggaac tgttaagcaa gcctgggata ccaagccttt ttgagtgagt

52441
cccgccagcc cgagggtgtg tagaggggtt gtgtgcctgg ccaggtagga ggcggggctg

52501
tgagaacctg ccagtactcc cgaaaggcgg aaggagaaac tgagcttcta gcaggtgaag

52561
aagaggtagc tgggcctgaa gagccctgta tgaaggggca tcgtgggaga tttagatgat

52621
cggacctttt gaccctgggg acaggtttcc ctgccagttt aaaaactcac attggttggc

52681
cgggcacatt ggctcacacc tataatccca gcatttttgg aggccgaggt gagcggatca

52741
cttgagctca ggagtttgaa accaacctgg gaaacatagg gagaccccat ctctacaaaa

52801
aaaaaaaaaa aaaaaaaatt agctgagcat ggtggagtgc ttatgtcgtc ccggctactt

52861
ggaagctgag gtggaaggat cgcttgagcc caggaggttg agtcagcagt aagctgtgat

52921
cacaccacca cactccagtc tgggcagcag agcagggccc tgtctcaaca aaacaaaact

52981
caaattggtg accttctatc cccaaggtca ctgtgtcatg gcgtgcctga catggtatgt

53041
gatgtgtctg tactgggctc tggaggatca ctaggtttct ccttgtacag acacgttcag

53101
tcctgtcgga agctgcggga ggggaggacc gccccgtcat ttgccacatc aggcagccag

53161
gactcagaga ggggatgtga cttaggaagg tcacagtgac tccacttccc aggcagccct

53221
agaggttcca gcctgacagc ttgtcattcc tgccccaatc tcccagccct ggcccaggga

53281
ctttcgcctg ggactgccca gtggtgccag ctctgtgggc ccaggaagcc tggctcctcc

53341
gggctaggtg ggggtagggg agatggccca aaaagcacag aaatttagac cagggggtag

53401
atatttcctc agcaagtttt tcctgagcct tgctgtggtc aagccccctg caaggccctg

53461
gggccacagg aggtcccaga ctgaggggaa gtggagccag gtgtggtcac caatcttcat

53521
tcttagcttg ggatcgccct gggcagcctc cgtctcaggt ggaagacggg gtgggcagaa

53581
tacagagcag cgggacaaac gcagccccag gggttctcgg ccgtgagcag agcctgtgtc

53641
tctcccttag acaggtatac agggaggggc tgggatgcca acctactggg tcccccgact

53701
gtggctgtgg aaggttctgg atcttcagct gtcccaagcc ccggttggtc cacttcctat

53761
acctgagaag gggctccgtg ggtggagagt gggtcgggag aggtggccag gcagggtggc

53821
tgtggtttcc agctgccact gtcaccgccc actccactga gccatgccac ccgttctctg

53881
caggcaacca gacaccttgg cctggtgagg cctcgatgta ggggctgata ggtaggctca

53941
gagccatggc aaccggtggc cacctcctcc ctgccggcgc caggagcgga gactgcagag

54001
ggaccgggac ttagatgaga gaggtctccc cagcaggaag ggagggtctg gtggttggca

54061
cccactagat gagcatggtc agaaaaatat caggatgagc aacttcttta tctaggcctg

54121
ggtgggggtg cctggcacag gtctccatgg gacatgctgc agctggtagc ccccagaccc

54181
cggggctgtg cccccctggg cggcacccag aaggtagggc ttgccaggac tgacccttcc

54241
caaagagatc taggcgggga ccagagggtt tctgacccca gcctgtgact ggctccacct

54301
cccatagtct cctggagccg aggaaaggac aggactggcg ggcccatggg agggtccgtg

54361
gggcacttgg tcctcgtcag agggaggaac tggacagttc gcgcagtgct gctggtctgg

54421
actgccctct gagctctcag ggggtctcta tgcaggcaga gtcctcccag cccctctctc

54481
ccattcttgg gcgaggggtc ggctggagag aggcccctgg gacatctggg tgtgtgtgcc

54541
agccacccag cccaacttct tggctctctg agtgccacta tcaggaaagg ggccagggct

54601
gcctcagtgg ctgggaggcc tgcttggact tgggggttac ctagggcctt agccctcttg

54661
gctggcttcc caggagctcg gtcccacagg acttggggac agggtgggtg cagcacgctc

54721
ccctcaccag cccccattgg cttcctgctg gacccaactc acctccctcc tcatctcccc

54781
acagcccgat ctgctcaact tcaagaaggg atggatgtcg atcttggacg agcctggaga

54841
ggtaagagga ctgaggccgg aggggaggaa gctggcttgt gctgctgctg ggcccctggg

54901
cagcccagga gtgggggtgg ggctggggct ggtgtgagaa ccctgggggt ggggctggga

54961
ggggtggagg ctgcccatta ggcttctgcc tcctggagca gtctgcagtg tgtaaaaggg

55021
atcacagcaa ggggccgtct agcccctcac acccagtgcc ccatcccttg atctcatcaa

55081
gagtctcttg gccctgccac ctcagtagga gcctgggtgg gagtcaaggg tcttgggtgg

55141
aagggctcgt agaagctgtc tggcccgaga cacagattcc taaagcctgg tctgaggggg

55201
gtggggctca gggcgcaggt gctggggttt cacccacctg gatccccact ggttgagtca

55261
aagcctcctc tagtcctcag tggccacgtc tgtgacatgg gcataatgga taatggtgat

55321
tctttctaga gtggataaca aggtcagaga gatcaagcac gtacaggtgc cacaaagctc

55381
ctggcactta ctgtgggctc agctaaagac ccttcccttc ctctggcata tgtgtccttg

55441
gaaccagcag ggacagtggc tgtttcctca gctctgttct ttcggctgcc aggctggctc

55501
cctgcccaca ctgcctgggc aggagcgtct ccccacccct gccctgcatg cgcctgctgc

55561
tctggtctgc gtgcagcctg catgccggag agggctttga gccagagggg atttcattgt

55621
gtttccggcc cacatgtttt attccctcca gcccacagcc ttccctaccc gctgcctgcc

55681
cgctgtccct ggtggctgct ctctaggctc acacaaagcc cggcaccccg ccagtgaccc

55741
cttcctggcc tccccaccca gggtccccgg agggcagagg gattacaggc cccacccaga

55801
gctggccatt agtcatcctc tatcacaggg ttctggaatg tccgaactgg aagggccctg

55861
ggaattcagc cagcccaacc ccttggtgca cagacaggag acgggcccat gagggtgttg

55921
gtctcttcca ggcctaggag cacctggggc agacccaggc tcagaactca gcgcacctga

55981
ggcccatgga gctccaccca gcttccatct cagacagtca taggctaggc ctggaagagc

56041
taaagaaacc tcttggcata gaacccctgt cctactttac agagaggcaa ttgaggtctg

56101
cagcagcaac tccgtttact tagtgagagg aaaatgcttc taagaggcct ggcctcccag

56161
aacaaaccca gcaacctggt tggtgtccat ccctatgcca agggccatga cagccatcca

56221
cacaagagag gatgggcgcc gctcgcctca ccagaaggtc taggcacttc tttttttgtt

56281
ttttattttt gttttttttt ttctgaggca gagtttcact cttgttgccc aggctggagt

56341
gcagtggcgc aacctcggct cactgtgtct tccgcctccc gggttcaagc gattctcctg

56401
cctcagcctc ccgagtagcc gggattacag gcatgcgcca ccatgcccat ctaatttttt

56461
tttgtatttt tagtagagac agggtttctc catgttggtc aggctggtct cgaactcctg

56521
acctcagatg atccaccctt ctcagcctcc caaagtgctg ggattatagg cgcgagctac

56581
cgcgcccagc tatagggact tcttagtagc cctactttat ggttcagaag actgaagctc

56641
agaaaagtgg agacacttgc ctaaaggcac acagagagaa agggaactct tggatacaaa

56701
actccttttc tcagggaggc aatgtggaaa gaagcagaag gtatcgtcgt tgcatgcccc

56761
ttgagaactt accatcttct tgaggagaga aaactaagta cttgaaacaa ccaacagcac

56821
agacagggct tggtgatgtg agggaaccct gggagggctg gggaccgggt gatatgcact

56881
gaccctggca gtgggcgggc cgcgactggc attccagtgg agtgaccaga agcccagagg

56941
tgggctgggc ttggcatact atcaggctgt tctggcgccc ccaccccttt cctacatgtc

57001
ctgccaatct aaccccagct ggagcagaga caggcactgc aggaaggcac ccaatcacaa

57061
atcctaaact tacagcttag ggcgctctca cctgctgcgg atgtgggtag ccagcctaca

57121
gttcaagaag cagaccgtgc atctgggcgc ggtggctcac gcctgtaatc ccagcacttt

57181
gggaggccaa ggcaggtgaa tcacctgagg ccaggagttt gagaccagcc tggctgacat

57241
gatgaaaccc tatctctact aaaaatacaa gaaattagct gagcatgatg gcgggcgcct

57301
gtaatcccag ctactcggga ggctaagaca ggagaatcac ttgaactcag gaggaggggg

57361
aggttgcagt gagtggagat tgcaccattg cactccagcc tgggcaacaa gagcaaaact

57421
cctccatctc aaaaaaaaaa aaaaaaaaag gcagcagatt gtggctggca ctcactccta

57481
ctccagggct ccatccagtc ctacttccca ggggaccatt gtccctgacc atggtgatga

57541
tctgggggaa tatggaaaaa gacgtaacgt cctggccccg ctgagtccct gacttgctta

57601
cacaggtcat cacccctccc tgtctgcact gggtccgggg tgcctgagga gccttggcaa

57661
tcttaaaagg agctccaaga aggaaaggga gggtgtggtt acggagggga aaccaatcca

57721
tttcacagat gctacccctg aggctcagag aggaaatgga ggggccaggt ctcaaattgg

57781
cattttccgc ctccccaccc ctcctgtgtg cagcatagtg agtttggcag ccacacagga

57841
cacctgtaca atcacacaca ctggctcttt cattccatcc tccttgcagc ctccctcccc

57901
ctcgctcacc accacctcta cttcgcagtg gaagaaacat tggtttgtgc tgacagattc

57961
aagtctcaaa tattacagag actccactgc tgaggaggtg aggccatggg tgtactgatg

58021
aacccccgga agggcctggg gtggcctggc tgggttcact ggggtgggtc acaccagggc

58081
ccacacggac catagtgggc cctcttgctc caggcagatg agctggatgg tgagatcgac

58141
ctgcgttcct gcacggatgt cactgagtac gcggtgcagc gcaactatgg cttccagatc

58201
cacgtgaggc tgtgtgcagc ttgggggctg gtggtgggca gcatggctgg aggtccctgg

58261
gggaggtttt ggtgttgaac atggctcacc atggagactg gatcccttca ctcatttacc

58321
cagaggccct atcttcagag ccagagctgt gatgccaaca cttagcatat ctgggggaga

58381
cgctggagcc agcagggctc ttcccaggcc aatggaaggg aggttttgta ccccctgccc

58441
accccagact caagacctta gatgcatcct gggaaggaag ggccaccctc cctggggtcc

58501
atagtgggga gggagtcatg cggctggcca tgtggcaacc tacccatgcg gtggccttgc

58561
agaccaagga tgctgtctat accttgtcgg ccatgacctc aggcatccgg cggaactgga

58621
tcgaggctct gagaaagacc gtacgtccaa cttcagcccc agatgtcacc aagtacgtac

58681
taagctggac tggggccttg agggaggcac ttacccttgc gtccccgagt gggtttctag

58741
gtactcacct gagggctgca cctttctggg ccctcgtttc tctgtcaaca acatgggaag

58801
agagtagtga gcattctcgg tatcatccag aagtacactg agggtttgag gtttgatctg

58861
tcttctcaaa tgtgatgggg cctcttctct ttggaggaga tgcctgtgag tcaaaagccc

58921
ctgccaggtg gctgttctgt ctctgtgtct gtgccgtggg ggccgtgtct aagcctgtgt

58981
taggaagggg tggttaggta gttcagcctt ggcgcccaca cctcccggga tggggagctc

59041
actccttctg gaggctgcca cgggcactgg ggcaggaggg ctgagttacc gagtggcaga

59101
gccccccaca gtttataccc agatgcccat ggcgggctgg gacttggagc tgctgggcag

59161
cgggaacaga gtgtggtatt aaagggggct gggctgggtg tagtggctca cacctgtaat

59221
cccagcgatt tgggaggctg agatgggagg atcacttgag ctcaggagtt caagaccagc

59281
ctgggcaata tagtgagacc tcgtccctac aaaaaattta aaaatcagct ggccgtggta

59341
gggtgcgcct gtcagctgag gtgggaggat cacctgagcc cggaggccga gtcccccaga

59401
ctggccacac cgcggctatt cagccttagg ccagaggctt tcctgtctag gtttcagagt

59461
ccccatctgt cacgttagca tgtcatgtct gtacatgtgc caggatgtgc ccagagcact

59521
ttgtgaactc tgaagcactg tgcagttgga ctgttattta gcatctaggc ccagctgctt

59581
taagaaagaa accccgggca cagtaacttc atcgagatag atgttcatgt ctcccttcag

59641
aacagccccg aggtatgcag tcctggcctg gtggggctcg ctctgccgtt tcaggggagc

59701
cacctgccac acccactcgg cagcctatag tcacatggct acaagtagct gtgggaatac

59761
tgcgagtgta gtttttggca gggtgaccac gtacccagct atgactgtgg ataaagagaa

59821
ttgccatagt tgttcagagt ctctgcaact tgtgttctgt gcaccccgag gtcccgcctt

59881
caccccatca gcagtgactg ggcatccccc ttgccactgt gagcctcggg aacctgggac

59941
attggtctcc tacatcacct cattgatcac catttgcaaa aagccccctg cctgctttcc

60001
acgttcgccc accctgtcct cacatccatc ctgtgagagg cgtcgctgtc ccacattaca

60061
gatgaggtca ctgaagctca aagagggcaa agagaccagt gtggtggttc acgcctgtaa

60121
tcccagagct ttgggaggct gaggtgggag gagcacgtga gcccaggagt tcgagaccaa

60181
cctgggcaat atattgagac cccatctcta tcaaaaattt aaaaaattag ctgggcgtgg

60241
tggtgcatgt ctgtagtccc agctactcca gaggccgagg caggaggatc acttgagcta

60301
aggagtttaa ggctgcagtg aactatgatc acaccactct acttcagcct gggcagcaga

60361
gtgagaccct gtcccttgaa aaacaaaaac aagaacgggg gcgagggaag ccgggcatcc

60421
tggtgggtcc ctgggctgtc aagaggtgga gctgggatgt tcctggggtc tgttaaccag

60481
gaagctcagg tcgggctgct tccttccctg gggtctgtct ccagcccctg gcacagggcc

60541
tggcacacag gtgtcgctcc aaaagtgctc attgtgggac tgcaggggtg aggacccacc

60601
tgacgtggct ctgctggtgc cctaggctct cggactctaa caaggagaac gcgctgcaca

60661
gctacagcac ccagaagggc cccctgaagg caggggagca gcgggcgggc tctgaggtca

60721
tcagccgggg tggccctcgg aaggcggacg ggcagcgtca ggccttggac tacgtggagc

60781
tctcgccgct gacccaggct tccccgcagc gggcccgcac cccagcccgc actcctgacc

60841
gcctggccaa gcaggaggag ctggagcggg acctggccca gcgctccgag gagcggcgca

60901
agtggtttga ggccacagac agcaggaccc cagaggtgcc tgctggtgag gggccgcgcc

60961
ggggcctggg tgcccccctg actgaggacc agcaaaaccg gcttagtgag gagatcgaga

61021
agaagtggca ggagctggag aagctgcccc tgcgggagaa taagcgggtg cccctcactg

61081
ccctgctcaa ccaaagccgc ggagagcgcc gagggccccc aagtgacggc cacgaggcac

61141
tggagaagga ggtaggcacc acggctggct ctctaggagg ccccttgccc cagcgcccct

61201
ccagtccctg cattcatgcc ctggcatttg tcttgcactc ctacagtgat ggggagctca

61261
cccctgatct gctgtgagtg tgcaccccac actcctgcga actagaatct tcttccttag

61321
accttagtag tttggtttgg ttttgttttg ttttttccta gttctgccct tagcagccat

61381
agagaagaga agtgggaaga gaagggagag acctgccagg ctcacacctg taatcctaac

61441
attttgggag gccaaggtgg gagggtccct tgaagccaag agtttgagac cagtctgtgc

61501
gacatggcaa aaccccatgt ctacaaaaaa atacaaaatt tagctgggcg tgctggtgca

61561
tacctggagc cccagctact tgagaggctg aggtgggagg atggctggag cccgggaggc

61621
agaggatgca gtgagccaag atcaagccac tgcactccag cagtctggca atagagcccg

61681
actttgtctc agattaaaaa aaaaaaagaa gaagaagaag ggcgagaccg tttattgttc

61741
atcttctgcc cgtggcctcc ctgcctgcac tgactcgtgg aatcctcaca gcggcctcta

61801
cccctagggt ggacttcagc agttttactg acgggaaaac tgaggctcaa agatgtttcc

61861
tctgtcacct ccatgatgtg taaacatctg tgaccacagt ttccttttcc tatccctgtc

61921
tagccttctc tgggccaagg ctctcccagg tcattgacct ggccatccag gaaacagccc

61981
agcgtgtccc ctggctacat ctcactccag ggctgcttgc ccttctcaaa ccctgaggca

62041
ttcctaagcc ttccagggac gctgggcttg tatccgtgtg gagctggaag cctgcgggct

62101
cctcactgcc ttccaccagc cctgccccag cttccaggtc ccactgacca cccttctccc

62161
tcgtaggttc aggctcttcg ggcccagctg gaggcgtggc gtctccaagg ggaggctcct

62221
cagagtgcac tgagatccca ggaggatggc cacatccccc cgggctacat ctcacaggta

62281
aggccggggg gctgtttttc agggggaggg ggcagatttc tgcttgccgt gttatcagga

62341
aacagctgag attttgggag cccttcctgt gtgtgctgga acctgtgtgg ggcatttgac

62401
atgcgtcatc tcatttactc tccccacagc tggtgggcgt gatcactgtg cccgttttac

62461
agacaaggcc actgagctct gagaggttat gtgacttgcc caaggtcacc ccgcctgcag

62521
gtctcaaagg tgggatttga gcgagggtcc ggctgactgc agagcctgtg tgtgagtccc

62581
cgtgtgacac tctgcacttg gacccttgcc ccggggaagt ggggggctag tggccccgag

62641
agtcactccc tgaacacagg gaaatcctgc cgaggcccac tgggccaagg ccccacacaa

62701
ggaggtctgc aggacagggg agcctccagt agccctcaga gaatgcaccg tccgcctagg

62761
acagcggttc tcaacggggt ccattttgtc ccccttgggg acatttggct gtgtctggga

62821
atacttctgg ttgtcacaac taggacaaac taactctcta gaaaaaacgt gtgtgtgtac

62881
acatatataa gtttattata aattttacca ataaaaacaa tgcttagtac acaatttaca

62941
aataaaaata tataatttta ttgtgaattc cgtacagcaa atggattttt ctcagaatgc

63001
tttcagtgat tttttccata ctcttgtatc cacaactgat taacaaaggg ggttgttcta

63061
acgtgtgctg gttgacattt ttgtttatgg taatgagtaa gatgagaaga catttgtcga

63121
aactttactg gtccatgttg tcagctactt ctttgctaga tcggatagta gttttctatt

63181
gagaatattt gagaatattc tattaagaat atttttgcaa ttttttgttc tatttacaat

63241
gtaatggtta tagatgtgag atacttctaa gtttaatctg cattattagc attttcttat

63301
cacttgctta agtctagaca atcaacaaaa caataaatca agccctgatg tgtaatgttt

63361
accaattctg cagtgtaaat actcccgctg tggccaatgc tgcattacca gcacaaagtc

63421
cctggacaga gagttgggaa gagatgtcac actattcact aggatttcca ccatgcggat

63481
acagtagatg tgattggccc caagagcacg cataatacaa cacagtgaaa tatttaggaa

63541
gtaataaatt tgagtatcta ttgccttgtc tttaacatag ttaatttaaa gtatataaat

63601
ttaattgtta atggctgtgc ttaacaacta catcacagaa ttactaaaaa tttgacaatc

63661
agctgtctgt agttatcaca ccattatcta aagtagaaaa gaaggggcca ggcgcagtgg

63721
ctcacgcctg taatcccagc actttgggga ggccgaagtg ggcagatcac gaggtcagga

63781
gaacgagact aacctggcca acatggtgaa actccgtctc taataaaata caaaaaatag

63841
ccgggcgtgg tggtgcgcac tgtagtccca gctacttggg aggctgaggc aggggaccca

63901
ctggaaccca ggaggcgcag gttgcagtga gccgagattg cgccacggca ctccagcctg

63961
gcgacagagt aagactccat ctcaaaaaaa aaaaaaaaga aagaaaagaa aagaaggctg

64021
agatctaggc cctaggcagg aggagccttc taaaaatttc caaggggagg tcacgtcatg

64081
agggggctct caggaaggca ttggctgggg catgagaagg aaggctggtt ggtgcgtatt

64141
gtggatgcct ccagtgctga gctaatagtt agaagctctg gcctggtacg gtggctaatg

64201
cctgtatctc agcactttgg gaggtgaggt gggtggatca cttgaggtca aatgttcgag

64261
gccagtgtgg ccagagtggt gaaaccctgt ctctactaaa aaaaaaaaat acaaaactta

64321
gcagggcatg gtggtgggcg cctataatcc cagctactcc agtggctgag gcaggagaat

64381
cgcttgaacc cgggaggcag aggttgcagt gagctgagat cctgccactg cagcctgggt

64441
gacagtgaga ctctatctaa aaacagcaac aaaaaacaaa acaaacaaaa aaagagaagc

64501
tcattccaca gacttttgga ggtttggggt cagacagtga catcaggaaa gtgatgttgg

64561
agtggagggg gcttgggaga gggccaggtg taaggcatta ggaaatggct gaaggagggt

64621
gaatgtcaag ggtctggagg gaggagaatt tgggactgga tgaccagatc tacggaaggc

64681
agaggggcct ttgggggccc tgaggctggg gctgctgctc cagggaagcc cggagaccgt

64741
cctggggcca agtagtggat ggagtttcca ctgatagagg agcaggcagg ggaattgggg

64801
tgggacgcag agggtgaggc tgggggctta ccttgtcctg gggaggggca ggggaggagc

64861
cagtgttgtg ccctgtagcc tcccaccctg aggcagagaa gggagctggg ggcccaacac

64921
cccagctgag gcaggtggga gggcctccga ggcccccagc cagggggctt ctgcctgcgt

64981
gctctgctct aagaagctgc aggggctgct ttctgggtgg gtggggctgg gacccattcg

65041
tacccaccta taatcagagt ggcttcatct tcctccattt tattttattt taattttttt

65101
agagatgagg tcttttactg tcacccaggc tacagtgcag tggcacagag gctcactgca

65161
gcctcgaact ctagggctca agcagtcttc ccacctcagc ctcctgagta ggaaccacag

65221
gctacaccac catgcctggc taattaaaaa aatttttttg tagagacaag gtctcactat

65281
gttccctggg ctggtcttga actcctgggc tcaagtgctt ctctcatgtt ggcctcccaa

65341
agtgctgggg gtacaagtgt gaccactgca ctggcccacc tttgtccgtt ttactcatag

65401
agccagcttt agatttcctt tagataaagg ctctgccact acaatgacgt ttaaaaggca

65461
ctgctttggc ttctcagctt actggtggca aaactgaggc ccacagaagg gtgtgacctt

65521
tgagctatag gcagacctgt gtctggagtt caggcggtct ggtccccagg tgccccattg

65581
ggtgcaccaa agtctgtcag tgtttggtcc cgttagggtg ggatgggcac ggggagcagg

65641
tgggagggga gaagggaata actggggagc agagctgaag accaggcagg tggaggagtg

65701
accccagatg cggaaggcag cagagaagaa gagctgagtc atctgtatcg ccctcaggca

65761
cgggaggagg cggatggaaa ttcggtggac ctggaggagt gacagctggg agggattccc

65821
cagctggtat ctcgggctga gtgggtgccc ttccttcagg ggttgggggc ttgctgctgc

65881
acgacagctg tcgggtggtc tggggcttca cccactggac atctggtaaa gagaaccttt

65941
ccccactatt gcagtgggga cagaggcatt tctttatcta ctttgatgtc catgtcaaag

66001
gtggcagcca ggatcaggac accttgggcc actcaggaag gtaggtgaga gaggccctag

66061
gagcccctgt tcgtcagctg agtcccacct cctgatgtca gcccctgcac ccctgagctg

66121
ctgggtctgc ctgcctggtc tggccctctt cagaagagca gtgcccaccc ccacattgct

66181
gggctcccca ctggtggatg ctggcgtacc gtctccctct gtgcacaggg ttcccgtgcc

66241
cagggagcct cgggggctgg tcctgtgagg cctgctttac ggatgccaag actgaagctc

66301
agagggggcg aggggtttgt tcaggttcac tccaaggcgc agccagggtg aagaccgcct

66361
ctgaggtcca aagtcatgtt ctgttgtcct aagccaggag acacatagag ggcaggaaca

66421
gaagccaggg gacagacacc cctgtcgcca catgaagctc ttggccctcg ctcctccatc

66481
aaatcgtccc caggtgtggc tgctggagag gcggggaggt ggcctttgcg tgggggagac

66541
agtccctcat ctggtcctct gtgccttagt ttcttccctg gctcttcttc cccttccctt

66601
tttaatgacc ttaaacattt ttttaattat ataaaagaaa tgtttacatt ttcaaaaata

66661
atttaaacaa attgaaaggc tggaaatcaa caccctcaca ctccttctgc tgccagctgc

66721
caccccaggg tcctgtcggt ggctgctgcc gcctgcctat cagtttctgg tggcagctgt

66781
aacctgtaac cacagctacc taaataatgc acatgtatta cctcacgctt ctgtaggcga

66841
gaagtctaac gcgagtcttg ccgcgctgca gccaaggcgt gggcaggact gtgttcctct

66901
gcaggcaccc gttgtatccc ttgcctgctc cagcttctgg tggccgtccg cgtcccttgg

66961
ctctcggccc cttccttcat cttcaaagcc tgcagagggg aagtcgagtc cttctcctgc

67021
cacgtcactc tgaccatccc ttcctggtca cacctccctt gaactcttcg cttctgcccc

67081
cttcgtccac ttttaaggac ccttgtgatt acactgggct tgagggataa tctgggataa

67141
tctcccgatt ttaaggtcag ctgattagca accttgattc cctctgcagc ctgaattcct

67201
ctttgccatg taacatgatg tagtcacaga tcctgggagt aagatgtgga caactttgag

67261
gggctatcat tctgccccct acaatatcct ccctaccttt tctgtgtttt ctgtgttttc

67321
cattcactgg gacggacagg tctgcacgtt tgttcccgtg agtgagatca taccacgtgt

67381
atgtcagaag ccaactttca ccacctcatt ttgggatctt tttccacagc atccacacaa

67441
aaactctgtc tagcagctgc ctgtgtccca ttgtcaagct cgatcccatc atttattcaa

67501
gagttcccct gatagggatt tagattgttt ccagttttca tctgttacca acctggctgt

67561
agggaatacc cttgttccaa aagtctctgt acacatacga ctttctgtgg gatcatttct

67621
gggagtgaac ctactaggtc aaccagtggg gtcgcaaaat gtgatgatgc caccggacca

67681
cccccaacac acaccgttgt ggcggacact cccagcagtg ggtattatta gtctgagata

67741
cttgcccatc ttgtctacta agcattattt tgtattacat catcagtttc agctcattta

67801
ctgagcacct gccacatgtc aggccctggc ctagaccctg gggactgcgc cagtcagatg

67861
ttctcagtct tcagggaatt tatggtttgg cagaggtaga accttttgag gcaggggaga

67921
ggctgcccag agacagagct aggagagaca tttaaactgg gctgcaggtc agtaaattac

67981
ccagggaggt aaagttgcca aaaaaacatt ccaggccggg cacagtggct catgcctgta

68041
atcccagcat tttgggaggc caaggccggc agatcacaag gtcagaagtt caagaccatc

68101
ctggctaaca cagtgaaacc ccatctctac taaaaataca aaaattagct gggcgtggtg

68161
gtgggcacct gtagtcccag ctactcacga ggctgaggca gaagaatcac ttgaacccag

68221
aggtggaggt tgcagtgagc tgagattgct ccactgcact ccagcctggg tgacagaaca

68281
aaactctgtc tcaaaaacaa aaacaaaaac aaaaaaacca caaaattcca ggcagtggga

68341
atagctaaag ctcagaggtg tgaacgtgct gcaaccgtaa ctgtgagatt gcttggcaga

68401
gaaaggccag ggatgagaac gtaaaggtca gccatgggaa cggggacttg actctgtagg

68461
acgaggaatc cctggagggc ttgaggcagg agcgacaagg tgaggtttgt gaatgaggag

68521
ccgtggggtg ggggtgggag caggagcagg tgcagactgg aggtgctggg acccaggagg

68581
aggtggtgta cctgcccctg agccttctcc tctggaggct ggggaagggc cgctgtccag

68641
aggaacgggg cagcctgtga caccctggcg tccggcccac aggaggcatg tgagcgcagc

68701
ctggcagaga tggagtcctc gcaccagcag gtgatggagg agctgcagcg gcaccacgag

68761
cgggagctgc agcgcctgca gcaggagaag gagtggctcc tggctgagga gacggcagcc

68821
acggcctcag gtatggaccc tggggggggc acagtgggct gggctctgag cctctgtgct

68881
gaggttcctc ctagccaaac tggggaggat tttatcaaat aagatgtagg ggtctcagtg

68941
ccacatttgg ggtaaagggt cagcaggtgt tagaagctcc aagaactggc ctgtagccct

69001
acttaaaaag ggaaactgag gcagtaaaag ataccctccc cacccccaac accaccacta

69061
ccataggtgg tgactcttcc tgctcagggg cctgcagcca ccatagagtc tgcctaaagg

69121
cacatgctac ccacgtgcgt gggggagagg ctgatcagct gcatcccctg tcctcatagg

69181
agtgcctcct ccctgggcac atgggccaga ccctggggag agcaggggaa ggtgtgagca

69241
ttgtccatgc cagctgtgtg ccaggcactg ggccccacat gtttcccaca ggagcaccct

69301
tcatcctgga caattccctc ccctcctgcc accgcacacc tgctgtgtgc ctggcacatt

69361
cctaggcatc actaggggtt tgcagaacaa tagaaatgct ggccaatgtc acatgatctg

69421
aagctcacaa cctgccagtg ctgtgccaag tgctcatgca ctcgaaccca gccttggggc

69481
cagtgtgctc tgcatttcag gaagatcgcc tttgcagccg cgtgtgttag agaccccttc

69541
cccctcagca gagtctggac ttcgccctgt aatctggcac taaggtttct gctgtgaaat

69601
ggataaaaat cacacttaag tggaataata aagaccataa atagcctcat gtccgttcag

69661
ggtggggatt gccaccaaaa gatttaccag aggcccggtg cagtggctca tgcctgtaat

69721
cccagcactt tgggaggctg aggcgggcag atcacctgag gtcaggagtt cgagactagc

69781
ctggccaaca tggtgaaacc ccatctctac taaaaataca aaaattagct gggcgtgatg

69841
gtgggcagct gcaatcccag ctactcagga ggctaaggca ggagaatctc ttgaacccag

69901
gagacagagg ctgcagtgag ctgagattgc accactgcac tccagcctgg atgacagagt

69961
aagactccat caaaaaaaaa aaaggccagg cactgtggct catgcctgta atcccagcac

70021
tttgggaggc cgaggcaggt gcatcacgag gtcaggagtt caagaccagc ctggccaaga

70081
tggtgaaacc ctgtctctac tatgaataca aaaattagcc atgcgcggtg gcaggcgcgt

70141
gtaatcccag ctactcagga ggctgaggca ggagaatcgc ttgaaagtgg gcggcaaagg

70201
ttgtagtgaa ccaagattgt gccactgcac tccagcctgg gtgacagagt gagactccgt

70261
ctcctgggtg acagagtgag actccgtctc ctgggtgaca gagtgagact ctgtctcaaa

70321
aaaaaaaaga aagaaaaaaa ggagagaaac tttcaatgtt cagaagtttc ggattttaga

70381
attgtgggta aaaccatggg tggccctgag tgggaaaaaa aaagcctcgg tctcagtcct

70441
taggagctca caatctgaga ataaagccag caggagctaa tgttggggca tttactctga

70501
gccatgcttt gttctaaatt cttcacacac cttccaataa ccccatggag gaaaggtact

70561
gttgttatcg atccctgttt tccagataag ggatctgagg cacaaggggt taagtcacct

70621
gtgcaaagtc acatcggttt atgctgactg tggagcctga gctcttgacc acgaggctgg

70681
tcaaagcaga taggccttgt ttgagagccc tcagagtctg cagggggggt gtactaggtg

70741
gggtcctacc tggaaatcac tagaacagga ggtaccaatg gtcagaccct gagctgtctc

70801
cccagtaggg tccatccaac aggattatct tcccttaata gatgggctga gagaggttga

70861
gagcttaccc caagccactc agtttatgac acaacctggg ctactctaga ctcctggttc

70921
ggtgctcttt gcatagcact ccttggtcca agtccatagt acttgcatag tactatgtgg

70981
agtccacata gtactccacc agtacatgtg gcgtctcaga gctggtggca cttggtgctg

71041
ctgacccccc tccagtctct cttgtgcctc tctgccctgc ttccagccat tgaagccatg

71101
aagaaggcct accaggaaga gctgagccga gagctgagca aaacacggag tctccagcag

71161
ggcccggatg gcctccggaa gcagcaccag taagatgatg ccggggccca actgcccacc

71221
ctgatggtta tgggttgagg aactttgctg aggccccttg gcagcggaca catcagtttg

71281
cccctagctg agattcctgc tccagtctca tggatgcaag aaacagaagc agaaggtcct

71341
caggcagacc ccatgccagt cctcacagac agtccttcag gcagcttctt gtcttggctg

71401
gtcccagcct ccacccacct cttcacccct ttagtctccc ctggagctgg gctgcagtgt

71461
cactgttgac cactaggcct ctccctgccc cagagcacag ttttggaatg ttgaggtttc

71521
aggggcttta actttaaaga tgggcccctc cagccgggca cattggctca tgcctgtaat

71581
cccagcactt tgggaggctg ggatcaggag ttcgagacta gcctggccaa catggtgaaa

71641
ccccatctct actaaaaata caagctagct gaatgtggtg gcgggagcct gcaattctag

71701
ctacttggga ggctgaggca ggagaatcgc ttgaacccag gaggcagagg ttgcagtgag

71761
ccaagattgt gccattgtat tccagcctgg gcaacaagag tgagagcaag actccatcta

71821
aaaaaaaaaa aaaagatggg ctcctccaag ccaccctcac ttagggtaaa cacctgtagc

71881
ccagagaagc tgtcactggt tcacagcccc acagcaggct aaaggcaaac ctagagaggg

71941
aaccccagag tcctgggatg ctttaagtct acctgactgg actccaggct tggcaggagc

72001
aagacaacct atgctctcct ctgctcctcc tctggggcag gtcagatgtg gaggcactga

72061
agcgagagct gcaggtgcta tcggagcagt actcgcagaa gtgcctggag attggggcac

72121
tcatgcggca ggctgaggag cgcgagcaca cgctgcgccg ctgccagcag gagggccagg

72181
agctgctgcg ccacaaccag gtgggcctgg ccccaggttg gggggacacg ggtgggtccc

72241
ggcacccctc ccctgaccac cgtgcctctc ccaggagctg catggccgcc tgtcagagga

72301
gatagaccag ctgcgcggct tcattgcctc gcagggcatg ggcaatggct gcgggcgcag

72361
caacgagcgg agttcctgcg agctagaggt gagtgtcctc actagcacca ggcagcccag

72421
tggttctcgg ggcccggggc tatggggcac ccccgccata ggctgggtat cacctgtggc

72481
aggaaagcca agtctcccag tggctgggcc agcctgacta ggctagaaca cctactgtgc

72541
atccagtagc cagcattctg ccctcccacc tgcattgtgt cacctacctg ccgtgtacca

72601
tagcaaatca ctccactttt ctgagtccca gtagctcatc tgtaaaatgg caccagcacc

72661
ttccttactg ggaaatattg gggtaagaaa atatgtgtgt atgtgtgtga tgccagtatc

72721
actgtagtat tttctttctt tttctttctt tctttttttg agacagagtc tctctctgtc

72781
acccaggctg gagtgtagtg acacgatctc agttcactgc aacctctgcc tccctggttc

72841
aagcgattct cctgcctcag cctcccaagt agctaggatt acaggcctgc accaccacac

72901
ccagctaatt ttttatattt ttggtagaga caagtttcac tatgttggcc aggctggtct

72961
cgaactccgg acctcaagtg atctgcctac cttggcctca caaagtgctg ggattacagc

73021
atgagccacc acacccggcc ttagtattta tttctttact tttttttttt ttttgagaca

73081
gagttttgct gttgttgccc aggctacagt gcagtggcgc gatctcggct caccacaacc

73141
tccgcctccc aggttaaaac gattctcctg gccgggcgcg gtggctcacg cctgtaatcc

73201
cagcactttg ggaggccgag gcgggcagat cacgaggtag gagatcaaga ccatcctggc

73261
taacacagtg aaaccccgtc tctactaaaa atacaaaaaa attacccggg cgtggtggcg

73321
ggcgcggtgg cgggtgcctg tagtcccagc cactccggag gctgaggcag gagaatggca

73381
tgaacctggg aggcggagcg tgcagtgagc cgagatcgtg ccactgcact ccagcctggg

73441
tgacagagcg agactccgtc tcaaaaaaaa aaaaaatatt aaaaaaaaaa agcgattatc

73501
ctgcctcagc ctcccaagta gctaggatta caggcatgtg ccacctcgcc tggataattt

73561
tgtattttta gtagagacag ggtttttcca tgttggtcag gctcttctcg aactcccaac

73621
ctcaggtgat ccgcccactt cggcctctca aagtgttggg attacaggcg tgagccaccg

73681
tgcccagccg atattttatt tctctttttt tttttgagac ggagtcactc tgtcacccag

73741
gctggagtgc agtggcacca tctcggctca ctgcaagctc cgcctctcgg gttcatgcca

73801
ttctcctgcc tcagcctccc gagtagctgg gactacaggc acccgccacc acacctggct

73861
aattttttgt atttttagta gagacggggt ttcaccatgt tagccgggat ggtcccaatc

73921
tcctgacctc gtgatccgcc cgcctctgcc tcccaaagtg ctgggattac aggcgtgagc

73981
caccgctcct ggccccaata ttttatttct tcaacaaaca cttaggtgag gctcactctg

74041
tacctagaaa ttctggaagc cctttttgtc tgttaactca tctaatcttc ctgacagctc

74101
catacattag ctactatgac tgtccccatt tacagatgag gaaactgagg cacaggaagg

74161
tcaagtacct taccaaagct tttatagctg gactgggatt tgaaccaggc agtctggctc

74221
cagtctgagc ttttaagcct ccccagtcct ggctgaactt gtttcctcct tggtcaagtc

74281
agcagcacct agccctcggg gttggggagg ggttaatgag gtgccttgtg gagtggttca

74341
gcctgctcag gtttatgtag ggcttctttt catccatctc actcccgagg tgagagcctg

74401
gtgctgcatg agggctgcag cagacttgac cgtgagatat ccactcacac gggctggaca

74461
ggggtgagag taagggaagg caaagcaggg gaatcggaga gggcttcctg gaggagtccg

74521
cctccaggat gtagagggtt tttgtgcaga taggggctgc attctagggg cctgaggcag

74581
agagaacccg ggctgcaggg cactatgggc cagggtagct ctggcttctg gccctgggtc

74641
agtccagcac ctatatcccc aggtgctgct tcgcgtaaaa gaaaacgaac tccagtacct

74701
aaagaaggag gtgcagtgcc tccgggacga gctccagatg atgcagaagg taggtccttc

74761
cgctgggctg ggggccgtcg gggactctgg agccatctgg atgccatcct gtgagcacct

74821
gctctgtgcc aagccctcca ctcgcttcat ccttcctcag gctctcctgt gcttctccca

74881
tgtaggtgtc atcatcccca ttcactgaca gggaaactga gactaagaaa ggggaagtga

74941
cttccccaag gctgtacttg gcttctgttt atttagcatt atttaattta ttgattatta

75001
ttgagcacct actatatcct gggcactgtg ctaggtgctg ggaagacaga tgtgaacaaa

75061
ataaccccaa atctctgctg tggggagctt gcactccagt gagaataacc acgttgctag

75121
gagttgggtg ggtcagggtt cagcccaggt ctgagtctgc agcccgcctg gcccaccctt

75181
ggctgctatg tcactgcctg gtgcgctctg tcagtttggg gcaggaagtg gacatgttgg

75241
tggctctgta agtgcacgtg agccagaccg tgtttaccgc acttgaagaa caggtggcgt

75301
gaactcacag gaagggcccg agcacccagc caggctgacc tggttctcat cccagccact

75361
cactgccctg cggtcttggt caaaatcttc tcccccgaaa caggatgagg atgacaatga

75421
cgcctgtgtc cctgggtggt accagggagg tgggaggggt aagcccagaa cccacggcca

75481
tcttggggag ccacctggag ggatgaagcg aggtatctgc ggggaggtct ggctgctggt

75541
gctgcccatg tgcccggttg gcagggctgg agggagagac ttcatgccct catacctgcc

75601
tcctgccccc caggacaagc gcttcacctc gggaaagtac caggacgtct atgtggagct

75661
gagccacatc aagacacggt ctgagcggga gatcgagcag ctgaaggagc acctgcgtct

75721
tgccatggcc gccctccagg agaaggagtc gatgcgcaac agcctggctg agtagaggtg

75781
gatgccgagg cgtgtgccct gcagggtggg caggggctga ggctctccca cacccgggac

75841
tccctggacc accccagcca ggccacttcc ttcttctggc ctccaattcc cgttctgtaa

75901
aaaggacaat gaaaccagca acacggggtt gttgcagaga tcccatcaga cccgggccac

75961
aggctgcttc atcagcttaa gcctgttcct ccagagctgg gcggcacagt gcagagccac

76021
agcctactca gtgcaccccc cttcttgggg ctggaggcaa atgcagcgtg cacatccctg

76081
acccccacag tgaatctcca ctgagcttca cacacacaca tcgcacgctg aggccgggct

76141
tctatcccag ttagtcttaa cactccttct tgacttagca gggctcaaag tggttggttg

76201
gttggttggt tggttggttg gttggttggt tggttggttt tggttgcttt gagaaaggtc

76261
ttactctgac acccaggctg gagtgcagtg gtgcaatcac ggctcactgc agcctcaacc

76321
tcctaggctc aagggatcct cccacctcag ccttctgagt agctgggacc acaggccctc

76381
accaccatgc ccagataatt tttgcacttt ttgtataggt ggggtttcgc cgtgatttcc

76441
caggctggtc tcgaactcct gggctcaagc aatacacctg cctcagcctc ccaaaattct

76501
gagattacag gtgtgagccg ctgcacctgg ccaaagtgtt cttatttttg ctttttcaac

76561
gccacatcta cctggagcat cctctttctg ataagtcctc atggacttcc tatggcatgc

76621
aggagaggcc accctatggc tgagctgctt gggaaggagc caggaagagc ggatctggct

76681
gtaccttagg ggctgagagg tggtggaagg acccactcag cacccttgct tggccttggg

76741
gtggcctcgc agcccctcag cccaggcctc agccctgccg caccttgtct ttcaggtccc

76801
gcccagctgc agaccctcca ggctggagga ccagccgccc tccttccctc ctggatggaa

76861
gtaaaaagcc aagctttctc cccaccctct gtgggccaca cgtgcacttg cacccaccac

76921
acacacacac acacacacac acacacacac agacacacag acacatacgc acacacgtgc

76981
acacatgtac acacggatac acacacacac acacacactg catatctgag cgcgcccctc

77041
gcactgggtc tcaccttgca ccttcttcag gattttatat gtgaagagat ttttatatag

77101
atttttttcc tttttttcca aaacacttta tactttaaaa aaaaaaaaaa aaagcaattc

77161
ctggtggctg tgtgcctcca accctggtcc ccctctgtct ccagccaccc tctgcttggg

77221
cttctgagct ggtggccctg gcccagaggt ctggcggagg cccaggcagc agccatggcg

77281
gggtgtctct acaggggaga ggcgggagcc tgccaccctc ttcctgccct acctcctact

77341
aacacttcct gccccatttg gacccgtacc atggggctca ggacagaggg agctagcagc

77401
tggcctccat ggccccacag cctccttcga ggctgtgctg ggtgcagaac cgccagagcc

77461
acccaaaagg tgtttctctt ctgctccctg aacctcttaa cttaataaaa cgttccagca

77521
gctctggtgt cctagatggc tggcagaaca ggaatggaga ttggggtttc ttgaagtggc

77581
ttccccactc acaccctacc cacaccccac ccttcctaaa gcagcggcct ctaggcttct

77641
gagggtgggg ctgaaaatcc aaggtctccc ttagtacaga ctgtgacgcc cccagtgtgg

77701
cttgcaggct agtggcagcg gaagcatgtg ggaaatagca agtccagtcc caccccaacc

77761
tactgaacca gcgtctgcat tttaacaggg tgccccagtg attcacgtga ccttcaaagt

77821
ctgaggagcc ctggagtagg gcccagggcc caggcctgag agagaggcct ggggctaaga

77881
ctagccctga ccatgacctt gggcaagtca cacccctcac tgagcctcag tttgcttctc

77941
catcaaatgg gtgtttttct ttcagtccca gtcctctcct gaggcttttc ccagaggtca

78001
tgcccagccc tgggcagggg tgagggcagg gttgtggctg ccaggcacag gtccagcggg

78061
ctgggagtcc tcaccatggc tggctgtgct gattatggtt gcatggggct gggaagaggt

78121
cccatttctg agccacagaa acaggccaca tccagtaggg gtcctggaag gctgtgagaa

78181
cccagaggag accctgaccc agcctgcagg tagaagactg cctttggagg cagctttgaa

78241
agatgactct tccagatgga agaatcagga agggccttcc cacgtggagg caccagcagg

78301
agcaaacgtc cctggtgtgt tcaggcaaag agccacagga gagtgacctc gtggagtggg

78361
aagagattgt ttcccattcc cttgccaggg attggttgag gaatggacaa ggcttgcagt

78421
tcacgcaagc cagtgaaatg cgaggggaag tcttgggagt ggggtggagg aggtcatctg

78481
ggaagggtgt ccttggtctt aaaaagaggc acaagaggcc gggcgcggtg gctcttgcct

78541
attatcctag cactttggga ggccaaggca gggggatcac ttgaggtcag gagttcgaga

78601
ccagcctggc caacatggtg aaaccccgtc tctactaaaa atacaaaaaa ttagccagac

78661
gtggtgccaa gcacctgtaa tcccagctac tcaggaggct gaggcaggag aatcacttga

78721
acccaggagg cagaagttgc agtgagccaa gatcgcgcca ctgcactcca gcctgtgtga

78781
caagggcgaa actccatctc aaaaaaaaag ggggagggtg gcgcaaggag aggacacctc

78841
tctcctggcc ctgtcgccat cttccctcat caatagctaa aaatggcaaa gaagaaagag

78901
ccaggacccc gtgccatcaa atcctccggc cttgtgctgc cctgtctcgg cactgcttgc

78961
cttaggagat caggagtgtt cctagccact gggagatggg atgcctgcca ctggcagctc

79021
tgccgtccat cctcaccatc ccaccgtccc cccaagacag ctctccatcc catcctctgc

79081
ctcccttcta gcctcaacct aactcagggc tcccccgtct cacacctggg ttgcaggaac

79141
atcctcttca ccaacccccc tcccatccct cctcagggct gcctagggca gctacaaaaa

79201
ccaggccagc ctctgaaagg tgctccacat ctcattaaaa accgtgaaat cgcactgccc

79261
cactatcaga atagctcaga ggagaaggtc tgccagtacc aagtgctggt ggggatacgg

79321
agaagagcag ctcccaggcg ctgctggtgc aaatgtgctt tgttgcaccc acggcaggaa

79381
actgaccagc ttctcatcaa gttaaatacg catctaccct atggcctagc atttccactc

79441
ttgcttacac atccaggaga aatgagtcct tacatgcaca aaaggatgag taccgtaata

79501
ctcacatcag caaataaaca atacagctgt gtgtcagtag tagaatgaat aaattgtggt

79561
cgattcata

Stereocilin

The STRC gene encodes stereocilin, a protein that is normally expressed in the inner ear and is associated with the stereocilia of specialized hair cells in the inner ear (see, e.g., Verpy et al., Nature 456: 255-258, 2008; and Zhang et al., J. Med. Genet. 44: 233-240, 2007). Stereocilia, which are about 10-50 μm in length, are important for hearing and balance. Stereocilia play a mechanosensing role in hearing. By bending in response to sound, they form a structure for mechanoreception of sound stimulation.

The human STRC gene is located on chromosome 15915. It contains 29 exons encompassing ˜19 kilobases (kb) (Verpy et al., Nature Genetics 29(3): 345-349, 2001; NCBI Accession No. NG011636.1). The gene is tandemly duplicated on chromosome 15915 in a telomere-to-centromere orientation, with the tandem copies located less than 100 kb apart on the chromosome. The coding sequence of the second copy is interrupted by a stop codon in exon 20, meaning that it is a “pseudogene” that encodes a nonfunctional truncated protein. (Hereinafter, references to “the STRC gene” mean the gene that does not have that stop codon in exon 20, while references to the “pseudogene” or the “STRC pseudogene” denote the gene that does have that stop codon in exon 20.) In some examples, the full-length STRC protein is a full-length wildtype STRC protein. The full-length wildtype STRC protein expressed from the human STRC gene is 1775 residues in length, and contains a signal peptide and several hydrophobic segments. When the signal peptide is cleaved off during processing of the wildtype protein, the resulting mature wildtype stereocilin protein is 1719 residues in length. In some embodiments, a full-length STRC protein can include a heterologous signal peptide positioned N-terminal to an amino acid sequence of a mature wildtype stereocilin protein.

Various mutations in the STRC gene have been associated with hearing loss (e.g., non-symptomatic sensorineural hearing loss). For example, a homozygous 1-bp insertion was identified in exon 13 in a consanguineous Pakistani family with autosomal recessive non-syndromic sensorineural deafness-16 (DFNB16) (Verpy et al. (2001). Another example found in a family with DFNB16 includes both a 4-bp deletion in exon 5 and a larger deletion encompassing exons 17-29. The two deletions were inherited from the father and mother, respectively. The 4-bp deletion was predicted to result in the translation of 5 out-of-frame amino acids and a premature stop codon in exon 5.

Additional exemplary mutations in a stereocilin gene detected in subjects having non-symptomatic sensorineural hearing loss and methods of sequencing a nucleic acid encoding stereocilin are described in, e.g., Verpy et al., Nature 456:255-259, 2008; Verpy et al., Res. Systems Neurosci. 519:194-210, 2011; Hofrichter et al., Clinical Genetics 87:49-55, 2015; and Mandelker et al., J. Mol. Diagnostics 16:639-647, 2014. Methods of detecting mutations in a gene are well-known in the art. Non-limiting examples of such techniques include: real-time polymerase chain reaction (RT-PCR), PCR, sequencing, Southern blotting, and Northern blotting.

An exemplary human wildtype stereocilin protein is or includes the sequence of SEQ ID NO: 34. Non-limiting examples of nucleic acid encoding a wildtype stereocilin protein are or include SEQ ID NO: 35 and SEQ ID NO: 36. As can be appreciated in the art, at least some or all of the codons in SEQ ID NO: 35 can be codon-optimized to allow for optimal expression in a non-human mammal or in a human.

In some embodiments of any of the compositions described herein, the STRC protein comprises a sequence that is at least 75% (e.g., at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%) identical to SEQ ID NO: 34.

Human Full-length Wildtype Stereocilin Protein

(Signal sequence shown in bold)

(SEQ ID NO: 34)

MALSLWPLLLLLLLLLLLSFAVTLAPTGPHSLDPGLSELKSLLSTLDQAPQGSLSRSRETTFLANISSSFE

PGRMGEGPVGEPPPLQPPALRLHDFLVTLRGSPDWEPMLGLLGDMLALLGQEQTPRDFLVHQAGVLGGLVE

VLLGALVPGGPPTPTRPPCTRDGPSDCVLAADWLPSLLLLLEGTRWQALVQVQPSVDPTNATGLDGREAAP

HFLQGLLGLLTPTGELGSKEALWGGLLRTVGAPLYAAFQEGLLRVTHSLQDEVFSILGQPEPDTNGQCQGV

FFLTLSLLGNLQQLLLWGVRHNLSWDVQALGFLSGSPPPPPALLHCLSTGVPLPRASQPSAHISPRQRRAI

TVEALCENHLGPAPPYSISNFSIHLLCQHTKPATPQPHPSTTAICQTAVWYAVSWAPGAQGWLQACHDQFP

DEFLDAICSNLSFSALSGSNRRLVKRLCAGLLPPPTSCPEGLPPVPLTPDIFWGCFLENETLWAERLCGEA

SLQAVPPSNQAWVQHVCQGPTPDVTASPPCHIGPCGERCPDGGSFLVMVCANDTMYEVLVPFWPWLAGQCR

ISRGGNDTCFLEGLLGPLLPSLPPLGPSPLCLTPGPFLLGMLSQLPRCQSSVPALAHPTRLHYLLRLLTFL

LGPGAGGAEAQGMLGRALLLSSLPDNCSFWDAFRPEGRRSVLRTIGEYLEQDEEQPTPSGFEPTVNPSSGI

SKMELLACFSPVLWDLLQREKSVWALQILVQAYLHMPPENLQQLVLSAEREAAQGFLTLMLQGKLQGKLQV

PPSEEQALGRLTALLLQRYPRLTSQLFIDLSPLIPFLAVSDLMRFPPSLLANDSVQQGYRGSEENSLEEDK

GLRPMTPRSLAAIRDYSPGMRPEQKEALAKRLLAPELFGEVPAWPQELLWAVLPLLPHLPLENFLQLSPHQ

IQALEDSWPAAGLGPGHARHVLRSLVNQSVQDGEEQVRRLGPLACFLSPEELQSLVPLSDPTGPVERGLLE

CAANGTLSPEGRVAYELLGVLRSSGGAVLSPRELRVWAPLFSQLGLRFLQELSEPQLRAMLPVLQGTSVTP

AQAVLLLGRLLPRHDLSLEELCSLHLLLPGLSPQTLQAIPRRVLVGACSCLAPELSRLSACQTAALLQTFR

VKDGVKNMGTTGAGPAVCIPGQQPIPTTWPDCLLPLLPLKLLQLDSLALLANRRRYWELPWSEQQAQFLWK

KMQVPTNLTLRNLQALGTLAGGMSCEFLQQINSMVDFLEVVHMIYQLPTRVRGSLRACIWAELQRRMAMPE

PEWTTVGPELNGLDSKLLLDLPIQLMDRLSNESIMLVVELVQRAPEQLLALTPLHQAALAERALQNLAPKE

TPVSGEVLETLGPLVGFLGTESTRQIPLQILLSHLSQLQGFCLGETFATELGWLLLQESVLGKPELWSQDE

VEQAGRLVFTLSTEATSLIPREALGPETLERLLEKQQSWEQSRVGQLCREPQLAAKKAALVAGVVRPAAED

LPEPVPNCADVRGTFPAAWSATQIAEMELSDFEDCLTLFAGDPGLGPEELRAAMGKAKQLWGPPRGFRPEQ

ILQLGRLLIGLGDRELQELILVDWGVLSTLGQIDGWSTTQLRIVVSSFLRQSGRHVSHLDFVHLTALGYTL

CGLRPEELQHISSWEFSQAALFLGTLHLQCSEEQLEVLAHLLVLPGGFGPISNWGPEIFTEIGTIAAGIPD

LALSALLRGQIQGVTPLATSVIPPPKFAVVFSPIQLSSLTSAQAVAVTPEQMAFLSPEQRRAVAWAQHEGK

ESPEQQGRSTAWGLQDWSRPSWSLVLTISFLGHLL

Human Wildtype Stereocilin cDNA

(SEQ ID NO: 35)

atggctctcagcctctggccoctgctgctgctgctgctgctgctgctgctgctgtcctttgcagtgactct

ggcccctactgggcctcattccctggaccctggtctctccttcctgaagtcattgctctccactctggacc

aggctccccagggctccctgagccgctcacggttctttacattcctggccaacatttcttcttcctttgag

cctgggagaatgggggaaggaccagtaggagagcccccacctctccagccgcctgctctgcggctccatga

ttttctagtgacactgagaggtagccccgactgggagccaatgctagggctgctaggggatatgctggcac

tgctgggacaggagcagactccccgagatttcctggtgcaccaggcaggggtgctgggtggacttgtggag

gtgctgctgggagccttagttcctgggggcccccctaccccaactcggcccccatgcacccgtgatgggcc

gtctgactgtgtcctggctgctgactggttgccttctctgctgctgttgttagagggcacacgctggcaag

ctctggtgcaggtgcagcccagtgtggaccccaccaatgccacaggcctcgatgggagggaggcagctcct

cactttttgcagggtctgttgggtttgcttaccccaacaggggagctaggctccaaggaggctctttgggg

cggtctgctacgcacagtgggggcccccctctatgctgcctttcaggaggggctgctccgtgtcactcact

ccctgcaggatgaggtcttctccattttggggcagccagagcctgataccaatgggcagtgccagggagtt

ttcttccttactctttccctcctaggtaaccttcaacagctgctcttatggggcgtccggcacaacctttc

ctgggatgtccaggcgctgggctttctgtctggatcaccacccccaccccctgccctccttcactgcctga

gcacgggcgtgcctctgcccagagcttctcagccgtcagcccacatcagcccacgccaacggcgagccatc

actgtggaggccctctgtgagaaccacttaggcccagcaccaccctacagcatttccaacttctccatcca

cttgctctgccagcacaccaagcctgccactccacagccccatcccagcaccactgccatctgccagacag

ctgtgtggtatgcagtgtcctgggcaccaggtgcccaaggctggctacaggcctgccacgaccagtttcct

gatgagtttttggatgcgatctgcagtaacctctccttttcagccctgtctggctccaaccgccgcctggt

gaagcggctctgtgctggcctgctcccaccccctaccagctgccctgaaggcctgccccctgttcccctca

ccccagacatcttttggggctgcttcttggagaatgagactctgtgggctgagcgactgtgtggggaggca

agtctacaggctgtgccccccagcaaccaggcttgggtccagcatgtgtgccagggccccaccccagatgt

cactgcctccccaccatgccacattggaccctgtggggaacgctgcccggatgggggcagcttcctggtga

tggtctgtgccaatgacaccatgtatgaggtcctggtgcccttctggccttggctagcaggccaatgcagg

ataagtcgtgggggcaatgacacttgcttcctagaagggctgctgggcccccttctgccctctctgccacc

actgggaccatccccactctgtctgacccctggccccttcctccttggcatgctatcccagttgccacgct

gtcagtcctctgtcccagctcttgctcaccccacacgcctacactatctcctccgcctgctgaccttcctc

ttgggtccaggggctgggggcgctgaggcccaggggatgctgggtcgggccctactgctctccagtctccc

agacaactgctccttctgggatgcctttcgcccagagggccggcgcagtgtgctacggacgattggggaat

acctggaacaagatgaggagcagccaaccccatcaggctttgaacccactgtcaaccccagctctggtata

agcaagatggagctgctggcctgctttagtcctgtgctgtgggatctgctccagagggaaaagagtgtttg

ggccctgcagattctagtgcaggcgtacctgcatatgcccccagaaaacctccagcagctggtgctttcag

cagagagggaggctgcacagggcttcctgacactcatgctgcaggggaagctgcaggggaagctgcaggta

ccaccatccgaggagcaggccctgggtcgcctgacagccctgctgctccagcggtacccacgcctcacctc

ccagctcttcattgacctgtcaccactcatccctttcttggctgtctctgacctgatgcgcttcccaccat

ccctgttagccaacgacagtgtacagcagggctacagagggtcagaggaaaacagtttggaggaagacaaa

gggttaagacccatgactcctcgcagcctggctgccatccgggattacagcccaggaatgaggcctgaaca

gaaggaggctctggcaaagcgactgctggccoctgaactgtttggggaagtgcctgcctggccccaggagc

tgctgtgggcagtgctgcccctgctcccccacctccctctggagaactttttgcagctcagccctcaccag

atccaggccctggaggatagctggccagcagcaggtctggggccagggcatgcccgccatgtgctgcgcag

cctggtaaaccagagtgtccaggatggtgaggagcaggtacgcaggcttgggcccctcgcctgtttcctga

gccctgaggagctgcagagcctagtgcccctgagtgatccaacggggccagtagaacgggggctgctggaa

tgtgcagccaatgggaccctcagcccagaaggacgggtggcatatgaacttctgggtgtgttgcgctcatc

tggaggagcggtgctgagcccccgggagctgcgggtctgggcccctctcttctctcagctgggcctccgct

tccttcaggagctgtcagagccccagcttagagccatgcttcctgtcctgcagggaactagtgttacacct

gctcaggctgtcctgctgcttggacggctccttcctaggcacgatctatccctggaggaactctgctcctt

gcaccttctgctaccaggcctcagcccccagacactccaggccatccctaggcgagtcctggtcggggctt

gttcctgcctggcccctgaactgtcacgcctctcagcctgccagaccgcagcactgctgcagacctttcgg

gttaaagatggtgttaaaaatatgggtacaacaggtgctggtccagctgtgtgtatccctggtcagcagcc

tattcccaccacctggccagactgcctgcttcccctgctcccattaaagctgctacaactggattccttgg

ctcttctggcaaatcgaagacgctactgggagctgccctggtctgagcagcaggcacagtttctctggaag

aagatgcaagtacccaccaaccttaccctcaggaatctgcaggctctgggcaccctggcaggaggcatgtc

ctgtgagtttctgcagcagatcaactccatggtagacttccttgaagtggtgcacatgatctatcagctgc

ccactagagttcgagggagcctgagggcctgtatctgggcagagctacagcggaggatggcaatgccagaa

ccagaatggacaactgtagggccagaactgaacgggctggatagcaagctactcctggacttaccgatcca

gttgatggacagactatccaatgaatccattatgttggtggtggagctggtgcaaagagctccagagcagc

tgctggcactgacccccctccaccaggcagccctggcagagagggcactacaaaacctggctccaaaggag

actccagtctcaggggaagtgctggagaccttaggccctttggttggattcctggggacagagagcacacg

acagatccccctacagatcctgctgtcccatctcagtcagctgcaaggcttctgcctaggagagacatttg

ccacagagctgggatggctgctattgcaggagtctgttcttgggaaaccagagttgtggagccaggatgaa

gtagagcaagctggacgcctagtattcactctgtctactgaggcaatttccttgatccccagggaggcctt

gggtccagagaccctggagcggcttctagaaaagcagcagagctgggagcagagcagagttggacagctgt

gtagggagccacagcttgctgccaagaaagcagccctggtagcaggggtggtgcgaccagctgctgaggat

cttccagaacctgtgccaaattgtgcagatgtacgagggacattcccagcagcctggtctgcaacccagat

tgcagagatggagctctcagactttgaggactgcctgacattatttgcaggagacccaggacttgggcctg

aggaactgcgggcagccatgggcaaagcaaaacagttgtggggtcccccccggggatttcgtcctgagcag

atcctgcagcttggtaggctcttaataggtctaggagatcgggaactacaggagctgatcctagtggactg

gggagtgctgagcaccctggggcagatagatggctggagcaccactcagctccgcattgtggtctccagtt

tcctacggcagagtggtcggcatgtgagccacctggacttcgttcatctgacagcgctgggttatactctc

tgtggactgcggccagaggagctccagcacatcagcagttgggagttcagccaagcagctctcttcctcgg

caccctgcatctccagtgctctgaggaacaactggaggttctggcccacctacttgtactgcctggtgggt

ttggcccaatcagtaactgggggcctgagatcttcactgaaattggcaccatagcagctgggatcccagac

ctggctctttcagcactgctgcggggacagatccagggcgttactcctcttgccatttctgtcatccctcc

tcctaaatttgctgtggtgtttagtcccatccaactatctagtctcaccagtgctcaggctgtggctgtca

ctcctgagcaaatggcctttctgagtcctgagcagcgacgagcagttgcatgggcccaacatgagggaaag

gagagcccagaacagcaaggtcgaagtacagcctggggcctccaggactggtcacgaccttcctggtccct

ggtattgactatcagcttccttggccacctgctatga

Human Wildtype Stereocilin cDNA - Codon Optimized

(SEQ ID NO: 36)

atggctctgtctctgtggcctctgctgctgctcctgttgctgcttctgctgctcagcttcgccgtgacact

ggctccaacaggaccccactctctggatcctggcctgagctttctgaagtccctgctgagcaccctggatc

aggctcctcagggcagcctgagcagatccagattcttcaccttcctggccaacatcagcagcagcttcgag

cctggcagaatgggagaaggacctgtgggagaacctcctccactgcaacctccagctctgcggctgcacga

ttttctggtcacactgagaggcagccccgactgggaacctatgctgggactgctgggagatatgctggccc

tgctcggacaagagcagacccctagagatttcctggtgcatcaggctggcgtgctcggaggactggttgaa

gttctgcttggagcactggtgcctggcggacctcctacacctacaagacctccatgcaccagagatggccc

cagcgattgtgtgctggctgctgattggctgcctagcctgctcctgcttctggaaggcacaagatggcagg

ccctggtgcaggttcagccttctgtggatcctaccaatgccaccggcctggatggaagagaagccgctcca

cactttctgcagggactgcttggactgctcacacctactggcgagctgggctctaaagaagccctttgggg

aggcctgctgagaacagttggagcccctctgtacgccgcctttcaagagggactcctgagagtgacacaca

gcctgcaggacgaggtgttcagcatcctgggacagccagagcctgacaccaatggacagtgtcagggcgtg

ttctttctgaccctgagcctgctgggcaacctgcagcaactgcttctgtggggcgtcagacacaacctgag

ctgggatgtgcaggcactgggctttctgtctggaagccctccacctccaccagcactgctgcattgtctgt

ctactggcgtgccactgcctagagcctctcagcctagcgctcacatcagccccagacagagaagggccatc

accgtggaagctctgtgcgagaatcacctgggacctgctcctccatacagcatcagcaacttctccatcca

tctgctgtgtcagcacaccaagcctgccacacctcagcctcatcctagcaccacagccatctgtcagaccg

ccgtttggtacgccgtttcttgggctcctggtgctcaaggatggctgcaggcctgtcacgatcagttcccc

gacgagttcctggacgccatctgcagcaatctgagcttctctgccctgtccggcagcaatcggagactggt

caaaagactgtgcgccggactgctgcctcctccaacatcttgtcctgagggactgcctcctgtgcctctga

ctcccgatatcttttggggctgcttcctggaaaacgagacactgtgggccgagagactgtgtggcgaagcc

tctctgcaagccgtgcctccatctaatcaggcctgggtgcagcacgtttgtcagggccctacacctgacgt

gacagcctctcctccttgtcacatcggaccttgcggcgagagatgtcctgatggcggcagctttctcgtga

tggtctgcgccaacgacactatgtacgaggtgctggtgcccttctggccttggctggctggccagtgtaga

atctccagaggcggcaacgatacctgtttcctggaaggactcctgggaccactgcttccatctctgcctcc

gcttggaccctctcctctgtgtcttacccctggacctttcctgctggggatgctgtctcagctgcctagat

gccagtctagcgtgccagctctggcccatccaaccagactgcactatctgttgcggctgctgaccttcctc

cttggacctggcgctggcggagctgaagctcaaggcatgcttggcagagccctgctgctgtcatccctgcc

tgacaactgcagcttctgggacgccttcagacctgaaggacgcagaagcgtgctgaggaccatcggcgagt

acctggaacaggatgaggaacagcctacaccaagcggcttcgaacccaccgtgaatcctagcagcggcatc

tccaagatggaactgctggcctgcttcagccccgtgctgtgggatctgctgcagagggaaaaaagcgtgtg

ggccctgcagatcctggtccaggcctatctgcacatgcctccagagaacctgcaacagctggtgctgtctg

ccgagagagaagctgcccagggattcctgactctgatgctgcagggaaagctgcagggcaaactccaggtg

ccacctagcgaagaacaggcccttggcagactgacagcactcctgctccagagataccccagactgacctc

tcagctgtttatcgatctgagccctctgatcccattcctggccgtgtccgacctgatgagattccctccta

gtctgctggccaacgactccgtgcagcagggatacagaggcagcgaggaaaacagcctggaagaggacaaa

ggcctgcggcctatgacacctagatctctggccgccatccgggattacagccctggaatgaggcccgagca

gaaagaggccctggctaagagactgctggctcccgagctgtttggcgaagttccagcctggcctcaagaac

tgctgtgggctgttctgcccctgctgccacatctgcctctggaaaacttcctgcagctgagcccacaccag

attcaggccctcgaggattcttggcctgccgctggactcggacctggacatgctagacacgtgctgagaag

cctggtcaaccagagcgttcaggacggcgaggaacaagtgcggagacttggacccctggcctgttttctga

gccccgaggaactgcagagtctggtgcctctgtctgaccctacaggccctgttgaaaggggcctgctggaa

tgtgccgccaatggaacactgagccctgagggcagagtggcctatgaacttctgggagtgctgagatctag

cggcggagccgttctgtcccctagggaacttagagtgtgggcacccctgtttagccagctgggcctgagat

tcctgcaagagctgtctgagccacagctgagggctatgctgcctgtgctccagggcacatctgtgacacca

gctcaagccgtcctgctgttgggcagactgctccctagacacgatctgtccctggaagaactgtgcagcct

gcacttgctgctgcctggactgtctcctcagacactgcaggccattcctcggagagtgcttgtgggagcct

gtagctgtctggcccctgagctgtctagactgagcgcctgtcaaacagccgctctcctgcagaccttcaga

gtgaaggatggcgtgaagaacatgggcaccacaggcgctggacctgccgtgtgtattcctggacagcagcc

cattcctaccacctggccagattgtctgctcccactgctgcccctgaaactgctgcagctggattctctgg

ctctgctggctaaccggcggagatattgggaactgccttggagcgaacagcaggcacagttcctgtggaag

aagatgcaggtccccaccaatctgacactgcggaatctgcaggctctcggcacacttgctggcggaatgag

ctgcgagttcctccagcagatcaacagcatggtggactttctggaagtggtgcacatgatctaccagctgc

caaccagagtgcggggaagcctgagagcttgtatttgggctgaactgcagcggcggatggccatgcctgaa

cctgaatggacaacagtgggccccgagctgaacggcctggactctaaacttctgctggatctccccatcca

gctgatggacagactgagcaacgagagcatcatgctggtggtggaactggtgcagagagccccagaacagc

tgctggcactgacacctctgcatcaagctgctctggccgaacgggcccttcagaatctggctcccaaagaa

acccctgtgtccggggaagtgctggaaacactgggacctcttgtgggcttcctgggcaccgagtctaccag

acagattcctctccagatcctgctgtcccacctgagccagctccagggattttgtctgggcgagacattcg

ccaccgaactcggatggttgctgctccaagagagcgtgctgggaaagcccgaactgtggtcacaggacgaa

gtggaacaggccggcagactggtgtttaccctgtctaccgaggccatcagtctgatccccagagaagcact

gggccctgaaacactcgagaggctgctggaaaagcagcagtcttgggaacagagcagagtgggccagctgt

gtagagaacctcagctggccgctaaaaaggccgcactggttgctggcgttgtcagacctgctgccgaggat

ctgccagagccagtgcctaattgtgccgatgtgcggggcacatttcctgccgcttggagcgctacacagat

cgccgaaatggaactgagcgacttcgaggactgtctgactctgtttgccggcgatcctggactgggaccag

aagaactgagagccgccatgggcaaagccaagcaactttggggacctccaagaggcttcagacccgaacag

attctgcagctcggccgcctgcttatcggactgggcgatagagagctgcaagaactgatcctggtggactg

gggcgtgctgtctactctgggacaaatcgacggctggtccaccacacagctgcggattgtggtgtccagct

tcctgaggcagtctggcagacatgtgtctcacctggacttcgtgcacctgactgccctgggctacacactg

tgtggactgcggcctgaggaacttcagcacatcagctcttgggagttcagccaggcagccctgtttctggg

aaccctgcatctgcagtgctccgaagaacaactggaagtgctcgcccatctgctcgtgctgccaggcggat

ttggccccatctctaattggggacccgagatcttcaccgagatcggcaccattgccgctggcatccctgat

ctggccctgtctgcactgctgagaggacagatccagggcgtgacaccactggccattagcgtgatccctcc

accaaagttcgccgtggtgtttagccccattcagctgtccagcctgacatctgcccaagccgtggctgtga

cccctgaacagatggcatttctgtctcccgagcagcggagagctgttgcttgggctcaacacgagggcaaa

gagagtcctgagcaacagggaagaagcaccgcttggggactgcaggattggtccagaccttcttggtcact

ggtgctgaccatcagctttctgggccacctcctgtga

A non-limiting example of a human wildtype stereocilin genomic DNA sequence is SEQ ID NO: 37. The exons in SEQ ID NO: 37 are: nucleotide positions 1-142 (exon 1), nucleotide positions 445-1230 (exon 2), nucleotide positions 1319-1343 (exon 3), nucleotide positions 2111-3368 (exon 4), nucleotide positions 4325-4387 (exon 5), nucleotide positions 4489-4605 (exon 6), nucleotide positions 4748-4914 (exon 7), nucleotide positions 5570-5756 (exon 8), nucleotide positions 5895-6010 (exon 9), nucleotide positions 6292-6424 (exon 10), nucleotide positions 6777-6959 (exon 11), nucleotide positions 7264-7302 (exon 12), nucleotide positions 7486-7653 (exon 13), nucleotide positions 7817-7882 (exon 14), nucleotide positions 8364-8489 (exon 15), nucleotide positions 9467-9525 (exon 16), nucleotide positions 10598-10721 (exon 17), nucleotide positions 10826-10938 (exon 18), nucleotide positions 13402-13537 (exon 19), nucleotide positions 13955-14151 (exon 20), nucleotide positions 14350-14440 (exon 21), nucleotide positions 14649-14805 (exon 22), nucleotide positions 15390-15559 (exon 23), nucleotide positions 17250-17405 (exon 24), nucleotide positions 17787-17929 (exon 25), nucleotide positions 18119-18267 (exon 26), nucleotide positions 18509-18605 (exon 27), nucleotide positions 18694-18841 (exon 28), and nucleotide positions 19041-19238 (exon 29). The introns are located between each of these exons in SEQ ID NO: 37, i.e., at nucleotide positions 143-444 (intron 1), nucleotide positions 1231 to 1318 (intron 2), nucleotide positions 1344-2110 (intron 3), nucleotide positions 3369-4324 (intron 4), nucleotide positions 4388-4488 (intron 5), nucleotide positions 4606-4747 (intron 6), nucleotide positions 4915-5569 (intron 7), nucleotide positions 5757-5894 (intron 8), nucleotide positions 6011-6291 (intron 9), nucleotide positions 6425-6776 (intron 10), nucleotide position 6960-7263 (intron 11), nucleotide positions 7303-7485 (intron 12), nucleotide positions 7654-7816 (intron 13), nucleotide positions 7883-8363 (intron 14), nucleotide positions 8490-9466 (intron 15), nucleotide positions 9526-10597 (intron 16), nucleotide positions 10722-10825 (intron 17), nucleotide positions 10939-13401 (intron 18), nucleotide positions 13538-13954 (intron 19), nucleotide positions 14152-14349 (intron 20), nucleotide positions 14441-14648 (intron 21), nucleotide positions 14806-15389 (intron 22), nucleotide positions 15560-17249 (intron 23), nucleotide positions 17406-17786 (intron 24), nucleotide positions 17930-18118 (intron 25), nucleotide positions 18268-18508 (intron 26), nucleotide positions 18606-18693 (intron 27), and nucleotide positions 18842-19040 (intron 28).

Human Wildtype Stereocilin Gene (NCBI Accession No. NG_011636.1)

(SEQ ID NO: 37)

1
gccctgccct cacctggcta tcccacacag gtgagaataa ccagaactca cctccggtac

61
cagtgttcac ttggaaacat ggctctcagc ctctggcccc tgctgctgct gctgctgctg

121
ctgctgctgc tgtcctttgc aggtaagaag aacagtgagc agaactgggg atgaggagga

181
gggtggctgg aaaaagactt taagaatatg gaggtgaacc tgttagatag aaggacaaag

241
gagagaggca gagacttgtg caaaagggaa aaatgagggt taagaaaagc aggccaagac

301
ttactgtagg ccagtgaaag gggttcagct caccatcccc tcacctcatc tttagatcca

361
ggtagggaac tgtgctcagg ggcagggttg agtttgggct ctgtgttcct ctccttcagt

421
gacctctggt ttctctcctt acagtgactc tggcccctac tgggcctcat tccctggacc

481
ctggtctctc cttcctgaag tcattgctct ccactctgga ccaggctccc cagggctccc

541
tgagccgctc acggttcttt acattcctgg ccaacatttc ttcttccttt gagcctggga

601
gaatggggga aggaccagta ggagagcccc cacctctcca gccgcctgct ctgcggctcc

661
atgattttct agtgacactg agaggtagcc ccgactggga gccaatgcta gggctgctag

721
gggatatgct ggcactgctg ggacaggagc agactccccg agatttcctg gtgcaccagg

781
caggggtgct gggtggactt gtggaggtgc tgctgggagc cttagttcct gggggccccc

841
ctaccccaac tcggccccca tgcacccgtg atgggccgtc tgactgtgtc ctggctgctg

901
actggttgcc ttctctgctg ctgttgttag agggcacacg ctggcaagct ctggtgcagg

961
tgcagcccag tgtggacccc accaatgcca caggcctcga tgggagggag gcagctcctc

1021
actttttgca gggtctgttg ggtttgctta ccccaacagg ggagctaggc tccaaggagg

1081
ctctttgggg cggtctgcta cgcacagtgg gggcccccct ctatgctgcc tttcaggagg

1141
ggctgctccg tgtcactcac tccctgcagg atgaggtctt ctccattttg gggcagccag

1201
agcctgatac caatgggcag tgccagggag gtgagtgtgg ccagggctgg gactgggatg

1261
tggcagggca aggaaagtga aattggggta gttttcttcc ttactctttc cctcctaggt

1321
aaccttcaac agctgctctt atggtaagta acaggagacc agttctgagg gattgggcct

1381
ggaaaatctg gaggtgaaga gctgaagacc tcagcctcta gagaggaaaa ctgatgggag

1441
gagtgtagtt tagtggtttt ggggtgtgac tgtctgggtt ggtgtcccag ctccacctct

1501
tcctagccat atgaccttga gcaggttaca tagtctttct atacctcagt ttccccattt

1561
ataaaatgag aatgataata ttagttacca cagagttgtt gcacccggtt aaatgagttg

1621
atactgtgta tgcaaacgac ttaaaaccgt gctggcacat agcgcttaat aatgttagct

1681
agtaaagatg ggatttggaa aataaggaca cagctggatt cctctacccc cttactactt

1741
cagtacaaca atgccagaca gtagttagac atattgagtt gctgagcaga tttcctaaca

1801
tgaggcccgc tgagggttgt gtttaagcta tctaaaagca tacgaagaaa ggagacagaa

1861
gggggccagg tggacagaaa gaattccaac tggggcttct cctaggtgat tttggacctt

1921
ggcagggcag ctttctcttt tttgccccgt tgcagcattt caaccagtaa cgcctaaact

1981
ctcagggacc tcgcttgtag aaaagcctat gcttgccatg ccccttgagg gctctgagtc

2041
agggtcagaa tcttcagctg gaggaaatgt gaactgacca gatcctgcct gctcctccct

2101
ctgcacccag gggcgtccgg cacaaccttt cctgggatgt ccaggcgctg ggctttctgt

2161
ctggatcacc acccccaccc cctgccctcc ttcactgcct gagcacgggc gtgcctctgc

2221
ccagagcttc tcagccgtca gcccacatca gcccacgcca acggcgagcc atcactgtgg

2281
aggccctctg tgagaaccac ttaggcccag caccacccta cagcatttcc aacttctcca

2341
tccacttgct ctgccagcac accaagcctg ccactccaca gccccatccc agcaccactg

2401
ccatctgcca gacagctgtg tggtatgcag tgtcctgggc accaggtgcc caaggctggc

2461
tacaggcctg ccacgaccag tttcctgatg agtttttgga tgcgatctgc agtaacctct

2521
ccttttcagc cctgtctggc tccaaccgcc gcctggtgaa gcggctctgt gctggcctgc

2581
tcccaccccc taccagctgc cctgaaggcc tgccccctgt tcccctcacc ccagacatct

2641
tttggggctg cttcttggag aatgagactc tgtgggctga gcgactgtgt ggggaggcaa

2701
gtctacaggc tgtgcccccc agcaaccagg cttgggtcca gcatgtgtgc cagggcccca

2761
ccccagatgt cactgcctcc ccaccatgcc acattggacc ctgtggggaa cgctgcccgg

2821
atgggggcag cttcctggtg atggtctgtg ccaatgacac catgtatgag gtcctggtgc

2881
ccttctggcc ttggctagca ggccaatgca ggataagtcg tgggggcaat gacacttgct

2941
tcctagaagg gctgctgggc ccccttctgc cctctctgcc accactggga ccatccccac

3001
tctgtctgac ccctggcccc ttcctccttg gcatgctatc ccagttgcca cgctgtcagt

3061
cctctgtccc agctcttgct caccccacac gcctacacta tctcctccgc ctgctgacct

3121
tcctcttggg tccaggggct gggggcgctg aggcccaggg gatgcbgggt cgggccctac

3181
tgctctccag tctcccagac aactgctcct tctgggatgc ctttcgccca gagggccggc

3241
gcagtgtgct acggacgatt ggggaatacc tggaacaaga tgaggagcag ccaaccccat

3301
caggctttga acccactgtc aaccccagct ctggtataag caagatggag ctgctggcct

3361
gctttagtgt gagtgctctg ccagagggaa agctcctaga acagtgagaa ggccctccag

3421
gggaattcct cgaatactca gaggcagtag tgtggggtag tagttgaagc acacagctct

3481
agagtcagac aggcttggat tcatatcttg gttctgtgac cagccttgaa tgagttattt

3541
aacttctctg agcaatattt ttctcgtctc atttataaac tagggatgat aatggtatat

3601
gagataatac atgcbgtggg cttagcacag tgcatgatac acaaacatgc aataaatatt

3661
accttgttat tcttttgggc tctttgactc tctcactttc tgcaccagaa agaaaaagga

3721
tcaagttaga ggactctaaa tttttcccct agagagtgag aattggaggc tggcagaata

3781
caggaagata aggtaggaat gagaaagatt cagggacact accaatcaga agactttggt

3841
tctaggttca actgtgccac aaattagtgt gatcttaggc aagcaatttc atttagtttt

3901
tctgggcttc agtttttagt ctgtagaatg gaggggtgag aatatgttaa acaccataat

3961
taattcactg agtgcctatt atatgcaagg cactttgcta ggttctgtag gatatataaa

4021
gatttcttac tccatgttgg ggccaccttt ttcaaaccct gggcccagta aaatggaatt

4081
agatagtctc atagtatttg gttcaggtct acaagtatta attgagccaa ctatggacct

4141
ggcatgggag agggtacaag agaaattaga gatatgatcc cggacctaaa agagcttaat

4201
atctgaagaa tcacacttga gatgatggac aagcatccca gcaagtggag ctggaatgcc

4261
tgggggagct gcaggagaga cagagaagac agctctgttg gcatattgtc tttcttccca

4321
ccagcctgtg ctgtgggatc tgctccagag ggaaaagagt gtttgggccc tgcagattct

4381
agtgcaggta acaggtggag ggcacatggg tgggcbgggt gacagccatg gctggaggtc

4441
cctgccccgt gaggtgaggc catacccacc atgacctcct attcgcaggc gtacctgcat

4501
atgcccccag aaaacctcca gcagcbggtg ctttcagcag agagggaggc tgcacagggc

4561
ttcctgacac tcatgctgca ggggaagctg caggggaagc tgcaggtgag cactgagaaa

4621
ggggagcaag ggcacctgga gcctagtgtt cagagggctt gctttagtgg gaggaggaac

4681
tccagagagg aaatggcagg gatactgagc atctccagag gcagaatcca ttcctgtgcc

4741
cctacaggta ccaccatccg aggagcaggc cctgggtcgc ctgacagccc tgctgctcca

4801
gcggtaccca cgcctcacct cccagctctt cattgacctg tcaccactca tccctttctt

4861
ggctgtctct gacctgatgc gcttcccacc atccctgtta gccaacgaca gtgtgtaagg

4921
ttcttgcact actcctcctg ctcctgtcac ggtcaggcca accgcatcca cctggagcag

4981
ccccttccgg agctcctctc tgtttttttc tttcatgcca gataggcaat gtgccaacat

5041
cgtagcaagg tttgagagag gcacatctca cgcctgagtg tgaaaaccca atcattatgc

5101
taatgaacta caaaaggatc agagagctcc tctctattaa aaccagggag aggatgggcg

5161
tggtggctca tgcctgtaat cccagcacgt tgggagcccg aggcaggtgg atcactaggt

5221
ccgcctagtg agttcgagac cagcctggcc aatatggtga aaccccgtct ctattaaact

5281
acaaaaatta gccaggcatg gtggtgggcg cttgtagtcc cagttactct ggaggctgag

5341
gcaggaggat agcttgaacc tgggaggcag aggttgcagt gaaccaagat cgtgccactg

5401
cactccagcc tgggtgacag agcgagactc cgtcttaaaa aaaacaaaaa acaaaacaaa

5461
acaaaaaaac agggagagtc tccttcctat ctagacagca gggctacaga gggtcagagg

5521
aaaacagttt ggaggaagac aaagggttaa gacccatgac tcctcgcagc ctggctgcca

5581
tccgggatta cagcccagga atgaggcctg aacagaagga ggctctggca aagcgactgc

5641
tggcccctga actgtttggg gaagtgcctg cctggcccca ggagctgctg tgggcagtgc

5701
tgcccctgct cccccacctc cctctggaga actttttgca gctcagccct caccaggtat

5761
gagaatcatc ttctttactt gactggccca tcttctgcta gtggggacaa agagtcaatg

5821
gcatgtctct cagtggcccc tccctgcaag aaccctatag tgaccccagt gcgagctaac

5881
cttccccatc tcagatccag gccctggagg atagctggcc agcagcaggt ctggggccag

5941
ggcatgcccg ccatgtgctg cgcagcctgg taaaccagag tgtccaggat ggtgaggagc

6001
aggtacgcag gtgagttgtt gtgggatcag taaccaaggc aagagtggaa gaggtagaga

6061
gaggaaggca cagcbgtcac gcbgggtcgg tgttctagga agaaaggggc aagagagtag

6121
gcagtggcct caggcagcat agagttccag gagagaggtc tatagatggt gcccctgtgt

6181
agtggtgtag tgtcagagtg cccagtgtat gtacccatac catctgctgc caggcctgcc

6241
ttagtgctag tcttggggac cacacaaagg tcagcttcat gccctcctca ggcttgggcc

6301
cctcgcctgt ttcctgagcc ctgaggagct gcagagccta gtgcccctga gtgatccaac

6361
ggggccagta gaacgggggc tgctggaatg tgcagccaat gggaccctca gcccagaagg

6421
acgggtgagc ccctcagcac aagcctacaa gactttaggc ttcccctggg tctgtgtgga

6481
tggctttccc attgtgtcaa cttgagcaca gtggtgccag cccccatccc acttttgcaa

6541
cctccattcc ttactccatg gccattctta cctgttacca cctcttcctg gcccttctct

6601
atctggtctg tagcacccca aacataccct ttgccatttt gaacctaatc tactccagtc

6661
caatccctag ttccaaaccc tagcccaggc cctgggaaat tcagatgtgg gattagagag

6721
gaagttcaag gttcatctgt cttttctctc cagtcctaaa ccttctttgg ttacaggtgg

6781
catatgaact tctgggtgtg ttgcgctcat ctggaggagc ggtgctgagc ccccgggagc

6841
tgcgggtctg ggcccctctc ttctctcagc tgggcctccg cttccttcag gagctgtcag

6901
agccccagct tagagccatg cttcctgtcc tgcagggaac tagtgttaca cctgctcagg

6961
tttgcctgtc tcactccctg gcatgtaccc tccatccccg cttgagcccc agtcaagaga

7021
atcccattca gggataaaag cagcccctcc tttccctggg tgaacagtag aggtaaactc

7081
tgtctgcagg aggacgcctt cattcccttt cctcagatca agaagggacc tgagtcactg

7141
aggatggtta ctagggatgg ttaagaggca gcgggaagtt ttggagggtt tgccttagga

7201
acccacttag gacctggctg ctgggtcctg agagcbgttg ttttcggtcc catcccaaca

7261
caggcbgtcc tgctgcttgg acggctcctt cctaggcacg atgtgagtag cagcaacttc

7321
tcagcctccc gccagaggtc tctatcctct tttaacctgg ctcctgcatc tgcccctcct

7381
ctctctccgc tcccctcata cttactgcct tgctgcattg tgattgttgt cttccccaac

7441
acccttccct tcttcttcag gcctcttgtc tctcttgctc tttagctatc cctggaggaa

7501
ctctgctcct tgcaccttct gctaccaggc ctcagccccc agacactcca ggccatccct

7561
aggcgagtcc tggtcggggc ttgttcctgc ctggcccctg aactgtcacg cctctcagcc

7621
tgccagaccg cagcactgct gcagaccttt cgggtatgag agtggcaagg aggatgagat

7681
aatcagggat accggctctt tctggttggg aggaaggcat cttccctgag gccagggaag

7741
gcctttcata cctccccact tacacacaca cacacacaca cacacacaca cacacacaca

7801
accaattctc atgcaggtta aagatggtgt taaaaatatg ggtacaacag gtgctggtcc

7861
agcbgtgtgt atccctggtc aggtaagtgt gagatctccc aactgagctc ctctccccat

7921
tctggggcag tttcatatgg ctggtgctac ctcccacact accctgcagt ggccctgaga

7981
gttctggtta gctctgtgcc cattagcagc cctccccagt gccagatgca ggacagcatg

8041
atccactcac attgtcctag actaatgtca aagctggaag ggcctgagaa atcttccagg

8101
ccacccaccc tgctttcaga tgaaaagacc aaggcbggga gaagctaagg gactttgttt

8161
gcctggtgcc taactagcag caacacttga ccacagcagc ctgcagtgtg aggctcttag

8221
gcgtttattg ctacagtggc aaatgccatt ccacttctgt cctagctttg gtccctttcc

8281
acccccatgg ttccttttct ctgagtgcta agtacagact ctctcaccta tcactacact

8341
gctataccca tcaccgccag cagcctattc ccaccacctg gccagactgc ctgcttcccc

8401
tgctcccatt aaagctgcta caactggatt ccttggctct tctggcaaat cgaagacgct

8461
actgggagct gccctggtct gagcagcagg taattctccc cacttaattt cagaacttcc

8521
tccctcaatg tagtctacct tctttaccta tcccttagcc ctatttggcc agcttatccc

8581
tactatcctt tatttgattg tttgagatac agtctcactc tgttgcccag gctgcagtgc

8641
agtggcatga tcagagttcg ctgtaacctc aaactcctga gctcaggcaa tctttctgcc

8701
tcagcctcct gaatagctag gacgacaggt ggttaccacc atgcctggct aatttttaaa

8761
tttttttttt gttttttgag atgaagtctt gctctgtcac ccaggcttga gtacagtggc

8821
acaagcttgg ctcactgcaa cctctgtctc ccgggttcaa gcgattctcc tgcctcagcc

8881
tcccgagtag ctgggactac aggcactccc cacaatgcct ggctaatttt ttttttgttt

8941
tagtagagac agggtttcac catattggcc aggctggtct cgaactgctg accttgtgat

9001
ctgcctgcct ctgcctctca aagtgctggg attacaggtg tgagccacca tgcccggcca

9061
atttttaaat tttttgtaga gacagacaat acaaaaatgt ggacactatg tggagacact

9121
atgttgaggt actatgctgt ccagattggt cttgaactcc tggcctcaag caatcctcct

9181
gccttggcct cccaaagtgc tgggattaca gacctgagcc actgcaccca gccccctagt

9241
atctcttata atgtgacttg cttttctttt tctttctcct tcccttttct ttcatttctt

9301
tctcactctc gagagaagag tgggcatctg ggagagtggg aggctggtgg gtcccacaga

9361
gtgaggaggc aggactgggt ccaaggcagt cctgcctctc cactctaggg ggtatccttg

9421
gacagtgtct cttctgggaa ggggctcgtc tttctttctc ttgtaggcac agtttctctg

9481
gaagaagatg caagtaccca ccaaccttac cctcaggaat ctgcagtgag taacttgtgt

9541
tgagcagtgc gctgaattcg accaacattt ttttgagtgc ttactatgtg ccaggcacca

9601
tgtgatatgg aatgggggat atagggatga atgatgcata gtccctgcct cgtggacgtt

9661
ctcctagcac ctccctttgc cctcctttcc ttccacagtg ccatgcctat cctgactaga

9721
gccaaaggac tcagaaaacc tggattcagg ttccagtcct gtcacctact tgtcctcttg

9781
ggcaagtcat ttaacgtccc tgtgtcagtt ttcccttctt taaatgagaa ttacaatggc

9841
accagcctca taggtagtta ctgtgaagat taaatgaggt aggtcatgta agatatttaa

9901
cacagtgttt ggtccattgt aaagtcccag tagtcatttg ctactgttag tttacttcag

9961
gatgacttca gaggcactgg ccaagcaaga ataaatagga ataagaaggt atcactttac

10021
ttacacccac attagaagaa caatgggctt cagaatcttt tttttttttt ttttttcgag

10081
acagtcttgc tctgttgccc aggctggagt gcagtggcgc gatttcggct cactgcaacc

10141
tctgcctccc aggttcaagc gattctcctg tctcagcctc tggagtagct gggattacag

10201
gaatgtgcca ccatacccag ctaatttttg tatttttagt agagatgggg tttcaccatt

10261
ttggccaggc tggtctcaaa ctcctgacct caggtgatcc acccgcctca gcctcccaag

10321
ggcttcagaa tctaagacat ggctctagtt tcagtttacc acatttctag cagaatgatg

10381
ttgggaatgt cacctgactt ccataaatcc ttattttctc ctctgataaa cagcagtgat

10441
gttatgggga gctgatgaga tatctatgta aaaacatttc tcaaaccata aattacggtg

10501
gatgaacatc tgtacttgtg ttgagagtac tgatatcaag gagcaaacag gctgttgtat

10561
gtgttgaatg agcctctccc cactcacaca cccacagggc tctgggcacc ctggcaggag

10621
gcatgtcctg tgagtttctg cagcagatca actccatggt agacttcctt gaagtggtgc

10681
acatgatcta tcagctgccc actagagttc gagggagcct ggtgagaggg ggtgcctgga

10741
ctttagtggg agcagggagg ctgggaccct aggtatagaa cccagctcct atgttctgct

10801
ctggcctcac actgcttccc tacagagggc ctgtatctgg gcagagctac agcggaggat

10861
ggcaatgcca gaaccagaat ggacaactgt agggccagaa ctgaacgggc tggatagcaa

10921
gctactcctg gacttaccgt aagtactgca gctagagata ttggcccctc agaaagctca

10981
atctggggtg aagatctgcc cttagggaat gccctggagg aggtagtttt tctgtctggt

11041
agttccctga cataatttat agcccaaagc agaggatttt attcaaagtt gctctatgta

11101
ttgactggtt cccagaatat gctccagcac agggcagctg agggtggcaa cactgtattg

11161
aagcctgcca agtaatctta caataaccta gtccacatta attgagattg agacagagca

11221
tctgaagtga gggaggcaat gctccaaatc tgccccagag gattgtagtt tgctcagggc

11281
actgtgttct tagtgcattc agaggagtag atcgagagaa aaatatatga aaaatgtgat

11341
aaataccttc aaatacctga ggggctatca agtagaaatt agattgtcat atttatgagt

11401
ggccccattg ggcaagacta agagtagtta acggagatca gatttttaca tagtataaga

11461
aaaactaagg tagtgagttc ctggtccttg gagcbgttcg agcctaagcc agatggcccc

11521
atggcaggaa tgttgtagag cacgttcata tacaggttgt gggaagaaaa ggctatagga

11581
acccaaggct cctccctacc catggagaaa tttattagta tgttactcat atgctgcttt

11641
tctcatttta cccctaccac caccccgttg ccatccgcac tgtaagtcag gataggaaaa

11701
tgcbggtgtt acagtcttcc tggggaatat ggagctgaag tggagtaaaa gcagttgact

11761
tcattcctac ttttttcttt tttttctttt tttttttttt tgagacagag ttttgctgtg

11821
tcaccaaggc tggagtgcag tgacgtgatc tcggctcact gcaacctcca tcttccaggt

11881
tcaagcaatt ctcctgcctc agtctcccga gtagcbggga ctgtaggtgt gcaccaccat

11941
gccaggctaa tttttgtatt tgttgtaggg acgagctttc accatgttgg ccaggctggt

12001
cttgaactcc tggcttcaag tgatctgccc acctcggctt cccaacattc ttatattttt

12061
ataggccttt ccacagattt cagctcttgt atgacttagc ccagttccag aactggtaat

12121
cctaggtagg gtacaggtta tcacctctga tttcgggtaa aagggattta tttatttatt

12181
tgtttattta tttatatttt tgagacagag tctcgctctg tcacccaggc tggagtgcaa

12241
tggtgccatc tcggctcact gcaacctctc cctctggggt tcaagcaatt ctcctgcctc

12301
agcctgctga gtagcbggga ttacaggcgc gtgccaccac acccggctaa tttttgcatt

12361
tttagtagag acggggtttc accatgttgc tcagggtggt ctcgaatttc tgaccctgtg

12421
atctgcctgc ctcggcctcc caaagtgctg ggattacagg catgagccac tgcgtccggc

12481
ctgtttttac ttttttttaa tgccattcag atctgtttaa atatgtgggt tctgtgagat

12541
aatttagaat cccaaggtta cagatgaggt gaaagatcct agaccatgca tcaaaaaact

12601
tgagtttctc atttgtgaaa gaaggataag agaaacacct attttgtctg ggtgcagtgg

12661
ctcatgccta taatcccagc atttggggag gccaaggtgg gtggatcacg gaggtcaggt

12721
gttcaagacc agactggcca acatggcaaa acaccatctc tactaaaaat acaaaagtta

12781
gcbgggcgtg gtggcacgtg cgtgtaattc cagctattcg ggaggctgag gcacgagaat

12841
tgcttgaacc tgggaggtgc gggttgcagt gaactgagat cgcagcacca ctgtgctcca

12901
gcctgagtga tggagtgagg ccaggtcttg ttgtaggatc aaatgagata acacctgaaa

12961
gaactttgta aattgtatag cacgtacaaa caagaaggga cctcttcaca agcagaggaa

13021
gggtggtcct gtggaaaaaa acgggaattg ggagtgagag acctcaacat ttgatctctg

13081
tgaacctcag ttttttaatc tataaaatgg ggaaatgtta atggtactta atatttggag

13141
cttttgagtc cattagatca ggtaggattg ttcgttattt ttttttttta ggaagactag

13201
aaatatgttg ctcccttttt ctcccccact caagcttgat ggtgggaatt ggccctggag

13261
ctgtttacta tcagttcctg tccagcttca ctaaatttgg tctggggtca catcttagct

13321
gcggactgtg gggttttgtg gtcccttctc gacttggccc agctccacct gaatcctgtt

13381
gttgtcaaat tgctgtaata ggatccagtt gatggacaga ctatccaatg aatccattat

13441
gttggtggtg gagctggtgc aaagagctcc agagcagctg ctggcactga cccccctcca

13501
ccaggcagcc ctggcagaga gggcactaca aaacctggta agagtccacc ctaccagact

13561
cagatttgct gccctgggca attcttgctc ctcagacaat gctctctgac tgtcccccaa

13621
ccctctactt cttgctttct tgctgccaaa cagattcctg tctacaaggc ctggcccctg

13681
ttttgcctct gggttctgtt ccttgataat atgcttcacg ttacttgtcc atacctcttg

13741
gagtccgaga aatctcttgg agtccacctc tcagtctttc tgcctgctcc tatctgggct

13801
cattgcttaa ggaagtgaac aaaggtagtg agcatcatag ggtgctgagc tgggagcagg

13861
agggagggaa ggttaggggg cttggtgtct tgatcaaggt gtctggtatt ctgagtcaga

13921
agtgcattgt ccaagttctg atgctcttct ccaggctcca aaggagactc cagtctcagg

13981
ggaagtgctg gagaccttag gccctttggt tggattcctg gggacagaga gcacacgaca

14041
gatcccccta cagatcctgc tgtcccatct cagtcagctg caaggcttct gcctaggaga

14101
gacatttgcc acagagctgg gatggctgct attgcaggag tctgttcttg ggtatggacc

14161
ttcgagaact tcagattcta actcattcta tacccagtcc ctcagccacc atcatcagtg

14221
gcagcctgtt ccatattctt aaggtcccct ggagccctgt gtccgaaatc ctagcatgtc

14281
ctcttttccc cttccttttc ctcacagttc cctcagctcc ccagcccccg attttcttcc

14341
tgtccccagg aaaccagagt tgtggagcca ggatgaagta gagcaagctg gacgcctagt

14401
attcactctg tctactgagg caatttcctt gatccccagg gtgagatgaa ggaagaaggg

14461
aagggagtaa atgcatagag gggactggtg agctggttat ggggacccgt ggccaaagag

14521
ggcaaaggat atgaagccta gatctggggg gagactgcaa aacagagaca ggactttgga

14581
cttagagcta tagcagcagg tcctgatctg tccagatctc cccactctcc ttctaccttc

14641
tcatgcagga ggccttgggt ccagagaccc tggagcggct tctagaaaag cagcagagct

14701
gggagcagag cagagttgga cagctgtgta gggagccaca gcttgctgcc aagaaagcag

14761
ccctggtagc aggggtggtg cgaccagctg ctgaggatct tccaggtgaa actacccaaa

14821
tacttatatg tccagcagga tgtacaggga gtatcaaacg gtctgggttc tacatgtgct

14881
cttccctggg actgggtttt ctaatttata aagcaaagag tttagaggga tgatcttcaa

14941
gcctcttgta gttctagaat tctgtagttc tgggagtttg taaactatta agttttcttt

15001
tagcccagaa cttccatttt cctgctctct cgtgtctgct ctagactcag ctctagctcg

15061
gctaagtgtg gagctctctg ctggggagat ccctagaagc tttgaaggag acattgtgag

15121
gctggagaac tgggttcaaa ttcagtgcta ccattaaatc tctgaataac atcctcagtc

15181
ttccatctat aaaagtcttg gcatctccaa tcacttcttg ttctattatc tcctaagccc

15241
tatacatatt actctgtaat actcctttga tccctatttc tcacagtgct ctatcctcca

15301
aaggttggaa gactcactct atctacagat atctctctgg gcatatttta ttactgcgct

15361
gacctcctgg ccctgccttc ccccttcaga acctgtgcca aattgtgcag atgtacgagg

15421
gacattccca gcagcctggt ctgcaaccca gattgcagag atggagctct cagactttga

15481
ggactgcctg acattatttg caggagaccc aggacttggg cctgaggaac tgcgggcagc

15541
catgggcaaa gcaaaacagg ttagggatgg agagccaact ggggttggcc atgaggaagc

15601
tatttgggtg tgatgtagga cacaaagaga atggagagtt ggatgagagg tgggggaagc

15661
aagagataga agagttagaa gatttgggtc acaagtagga ggtgaaggga gataaatatt

15721
gaggaaagag agctagtata atgaatagag ggacgaaagc agtggttacc aaattttaat

15781
gcatatcacg atcatcaagg gaacagattt ttttctttat ttttttttct ttcttaaaaa

15841
aataatggca tgcttcggct gggtgcagcg gctcacgcct ataatctcag aactttggga

15901
ggccaaggcg ggcagatcac gaggtcagga gatcaagacc atcctgtcta acacggcgaa

15961
acacggtctc tactaaaaat acaaaaaagt tagccgggca tggtggtgca cacttgttgt

16021
cccagctact tgggaggctg aggcaggaga atggcgtgaa cctgggaggg ggagcttgca

16081
gtgagccgaa gtcaagccaa tgcactccat cctgggtgac agagcaagac tccatctcaa

16141
aaaaaaaaaa aaaaaaaaaa ggcatgcttc atgaatttgc gtgttatcct tgcacaggcg

16201
ccatgcaaat ctctgtatca ttccaatttt ttggggtatg tgctgctgaa ctgagcatgg

16261
gaacagtgcc agtgccagat taccatgctt cactgactta ataaaaacct ttggggaggc

16321
tgggcgcagt gactcatgcc tgtaatcaca gcactttggg aggcggaggc aggtggattg

16381
cttgagccca ggagttagag accagactgg gcaacatggt gaaaccctgt ctctactaaa

16441
aatagaaaaa acattagctg ggtgtggcgg cacatgcctg taatcccagc tactcaggag

16501
gcbggggtag gagaatccca tgagtgcagg aggtggaggg tgcaatgtgc caagatcgca

16561
ccactgccct ccagcctggg tgtcagagca agaccctgtc tcataaatta aaaaataagc

16621
ctctggggga aagagtctag acatctgcat ctcctttttt tttttttttt tttttttttg

16681
agacagagtc tcactctgtc acccagcatc caggctggag tgcagtggtg tgatcttggc

16741
tcactgtaac ctctacatcc tgggttcaaa cgatcctcct gcctcagcct ctcaagtagc

16801
tgggactaca ggtgcaccac acctggctaa tttttgtatc tttggtagag atggggtttc

16861
actatgttgc ccaggatggt ctcgaacttc tgggctcaag caatcctccc acctcagcct

16921
cccaaagtgc tgggattaca gcbgttagcc actgtgctgg gccctaggca tctgttttaa

16981
taagcgtctc tgtgtctgat gcacataaaa gtgtggaact catggactag agttagtttg

17041
ctcttctttt ccactgattg taatgtcttt caaaacacct tagaggaact gtaaggcaac

17101
ggtctcattt tatagtggag gaaactaaag aaaaggcaaa tgatttacct agagttatac

17161
agctaagggc agaggcaaga cttaaaaccc agcagtatga ctcccaatcc actgcttttc

17221
cactcacatt gttcctgtct ttctcctagt tgtggggtcc cccccgggga tttcgtcctg

17281
agcagatcct gcagcttggt aggctcttaa taggtctagg agatcgggaa ctacaggagc

17341
tgatcctagt ggactgggga gtgctgagca ccctggggca gatagatggc tggagcacca

17401
ctcaggtaac acttttcctc ctccctacgg cttcccaaac acccatccca cagacccagc

17461
cctatagatc atctaaagcc caaggaattt ttttcctgtg accctacctg gtccttcttt

17521
ctatcttttg ttgatacccc atactagtga ccttcaggac tctgatttat tcactctgag

17581
gccctggaca cataatactg tctcctacct cttttcctgg aggcttcctc tttttctttc

17641
cttttctttt ctgagtcctc agccttcccc atgactcctt aggtcttaat agtaacagaa

17701
tataacccag taacacctat cacttccctg tccattaatt ctccataact ttcctccttc

17761
ccctcttctc ccacccccca ccccagctcc gcattgtggt ctccagtttc ctacggcaga

17821
gtggtcggca tgtgagccac ctggacttcg ttcatctgac agcgctgggt tatactctct

17881
gtggactgcg gccagaggag ctccagcaca tcagcagttg ggagttcagg tcatttgtga

17941
aggggctgag ggtggtggtg ctgaggtaaa ggtggactta ctggggaaag aaggatcatg

18001
aaggtctggt cccatggagg aagggaactc atttgaagcc atctcttcct ttgtctcatg

18061
accacagccc ctttcactga agccgaattc ttcttccttc cttcctactg ttctacagcc

18121
aagcagctct cttcctcggc accctgcatc tccagtgctc tgaggaacaa ctggaggttc

18181
tggcccacct acttgtactg cctggtgggt ttggcccaat cagtaactgg gggcctgaga

18241
tcttcactga aattggcacc atagcaggtg gggagctggg ccactgctgg tgcaagttgg

18301
tttggtttct ataccatggg tggactggat ggaagactgc cctgcaattc ttaaggtggg

18361
ggcctgaggg tgtttaaata aggggctaga gacatattgg ggaaggtcta tgatagggca

18421
ctttgggagt agttagagaa ggtctatagg tttgaagaga gggaaggtca gtctaagaca

18481
atgtttggat gccacttgct tcaacagctg ggatcccaga cctggctctt tcagcactgc

18541
tgcggggaca gatccagggc gttactcctc ttgccatttc tgtcatccct cctcctaaat

18601
ttgctgtaag tattaatgga ctggggtgac cacaggagag ccagggccca atggggacta

18661
catgcatgca ctgattccta cccctgccct caggtggtgt ttagtcccat ccaactatct

18721
agtctcacca gtgctcaggc tgtggctgtc actcctgagc aaatggcctt tctgagtcct

18781
gagcagcgac gagcagttgc atgggcccaa catgagggaa aggagagccc agaacagcaa

18841
ggtgagttcc cagctgcaca gcttgatcct ccatctcctg acccagaatc aaacccctaa

18901
tttggtgctg tctggctctt agagtgcacc cagggagatc cctggagtga aggagtctac

18961
aggcagagcg ctaatttcca agtatcaatg ctcctggaga gctgagttgt gatattactc

19021
ccattccctg tctattatag gtcgaagtac agcctggggc ctccaggact ggtcacgacc

19081
ttcctggtcc ctggtattga ctatcagctt ccttggccac ctgctatgag cctgtctcta

19141
cagtagaagg agattgbggg gagagaaatc ttaagtcata atgaataaag tgcaaacaga

19201
agtgcatcct gattattttc agaagctgat gaggaata

The nucleotide sequence of the human STRC pseudogene is shown in SEQ ID NO: 38.

Human Stereocilin Pseudogene 1 (STRCP1)

(SEQ ID NO: 38)

1
gccctgccct cacctggcta tcccacacag gtgagaataa ccagaactca cctccggtac

61
cagtgttcac ttggaaacat ggctctcagc ctctggcccc tgctgctgct gctgctgctg

121
ctgctgctgc tgtcctttgc aggtaagaag aacagtgagc agaactgggg atgaggagga

181
gggtggctgg aaaaagactt taagaatatg gaggtgaacc tgttagatag aaggacaaag

241
gagagaggca gagacttgtg caaaagggaa aaatgagggt taagaaaagc aggccaagac

301
ttactgtagg ccagtgaaag gggttcagct caccatcccc tcacctcatc tttagatcca

361
ggtagggaac tgtgctcagg ggcagggttg agtttgggct ctgtgttcct ctccttcagt

421
gacctctggt ttctctcctt acagtgactc tggcccctac tgggcctcat tccctggacc

481
ctggtctctc cttcctgaag tcattgctct ccactctgga ccaggctccc cagggctccc

541
tgagccgctc acggttcttt acattcctgg ccaacatttc ttcttccttt gagcctggga

601
gaatggggga aggaccagta ggagagcccc cacctctcca gccgcctgct ctgcggctcc

661
atgattttct agtgacactg agaggtagcc ccgactggga gccaatgcta gggctgctag

721
gggatatgct ggcactgctg ggacaggagc agactccccg agatttcctg gtgcaccagg

781
caggggtgct gggtggactt gtggaggtgc tgctgggagc cttagttcct gggggccccc

841
ctaccccaac tcagccccca tgcacccgtg atgggccgtc tgactgtgtc ctggctgctg

901
actggttgcc ttctctgctg ctgttgttag agggcacacg ctggcaagct ctggtgcagg

961
tgcagcccag tgtggacccc accaatgcca caggcctcga tgggagggag gcagctcctc

1021
actttttgca gggtctgttg ggtttgctta ccccaacagg ggagctaggc tccaaggagg

1081
ctctttgggg cggtctgcta cgcacagtgg gggcccccct ctatgctgcc tttcaggagg

1141
ggctgctccg tgtcactcac tccctgcagg atgaggtctt ctccattttg gggcagccag

1201
agcctgatac caatgggcag tgccagggag gtgagtgtgg ccagggctgg gactgggatg

1261
tggcagggca aggaaagtga aattggggta gttttcttcc ttactctttc cctcctaggt

1321
aaccttcaac agctgctctt atggtaagta acaggagacc agttctgagg gattgggcct

1381
ggaaaatctg gaggtgaaga gctgaagacc tcagcctcta gagaggaaaa ctgatgggag

1441
gagtgtagtt tagtggtttt ggggtgtgac tgtctgggtt ggtgtcccag ctccacctct

1501
tcctagccat atgaccttga gcaggttaca tagtctttct atacctcagt ttccccattt

1561
ataaaatgag aatgataata ttagttacca cagagttgtt gcacccggtt aaatgagttg

1621
atactgtgta tgcaaacgac ttaaaaccgt gctggcacat agcgcttaat aatgttagct

1681
agtaaagatg ggatttggaa aataaggaca cagctggatt cctctacccc cttactactt

1741
cagtacaaca atgccagaca gtagttagac atattgagtt gctgagcaga tttcctaaca

1801
tgaggcccgc tgagggttgt gtttaagcta tctaaaagca tatgaagaaa ggagacagaa

1861
gggggccagg tggacagaaa gaattccaac tggggcttct cctaggtgat tttggacctt

1921
ggcagggcag ctttctcttt tttgccccgt tgcagcattt caaccagtaa cgcctaaact

1981
ctcagggacc tcgcttgtag aaaagcctat gcttgccatg ccccttgagg gctctgagtc

2041
agggtcagaa tcttcagctg gaggaaatgt gaactgacca gatcctgcct gctcctccct

2101
ctgcacccag gggcgtccgg cacaaccttt cctgggatgt ccaggcgctg ggctttctgt

2161
ctggatcacc acccccaccc cctgccctcc ttcactgcct gagcacgggc gtgcctctgc

2221
ccagagcttc tcagccgtca gcccacatca gcccacgcca acggcgagcc atcactgtgg

2281
aggccctctg tgagaaccac ttaggcccag caccacccta cagcatttcc aacttctcca

2341
tccacttgct ctgccagcac accaagcctg ccactccaca gccccatccc agcaccactg

2401
ccatctgcca gacagctgtg tggtatgcag tgtcctgggc accaggtgcc caaggctggc

2461
tacaggcctg ccacgaccag tttcctgatg agtttttgga tgcgatctgc agtaacctct

2521
ccttttcagc cctgtctggc tccaaccgcc gcctggtgaa gcggctctgt gctggcctgc

2581
tcccaccccc taccagctgc cctgaaggcc tgccccctgt tcccctcacc ccagacatct

2641
tttggggctg cttcttggag aatgagactc tgtgggctga gcgactgtgt ggggaggcaa

2701
gtctacaggc tgtgcccccc agcaaccagg cttgggtcca gcatgtgtgc cagggcccca

2761
ccccagatgt cactgcctcc ccaccatgcc acattggacc ctgtggggaa cgctgcccgg

2821
atgggggcag cttcctggtg atggtctgtg ccaatgacac catgtatgag gtcctggtgc

2881
ccttctggcc ttggctagca ggccaatgca ggataagtcg tgggggcaat gacacttgct

2941
tcctagaagg gctgctgggc ccccttctgc cctctctgcc accactggga ccatccccac

3001
tctgtctgac ccctggcccc ttcctccttg gcatgctatc ccagttgcca cgctgtcagt

3061
cctctgtccc agctcttgct caccccacac gcctacacta tctcctccgc ctgctgacct

3121
tcctcttggg tccaggggct gggggcgctg aggcccaggg gatgcbgggt cgggccctac

3181
tgctctccag tctcccagac aactgctcct tctgggatgc ctttcgccca gagggccggc

3241
gcagtgtgct acggacgatt ggggaatacc tggaacaaga tgaggagcag ccaaccccat

3301
caggctttga acccactgtc aaccccagct ctggtataag caagatggag ctgctggcct

3361
gctttagtgt gagtgctctg ccagagggaa agctcctaga acagtgagaa ggccctccag

3421
gggaattcct cgaatactca gaggcagtag tgtggggtag tagttgaagc acacagctct

3481
agagtcagac aggcttggat tcatatcttg gttctgtgac cagccttgaa tgagttattt

3541
aacttctctg agcaatattt ttctcgtctc atttataaac tagggatgat aatggtatat

3601
gagataatac atgcbgtggg cttagcacag tgcatgatac acaaacatgc aataaatatt

3661
accttgttat tcttttgggc tctttgactc tctcactttc tgcaccagaa agaaaaagga

3721
tcaagttaga ggactctaaa tttttcccct agagagtgag aattggaggc tggcagaata

3781
caggaagata aggtaggaat gagaaagatt cagggacact accaatcaga agactttggt

3841
tctaggttca actgtgccac aaattagtgt gatcttaggc aagcaatttc atttagtttt

3901
tctgggcttc agtttttagt ctgtagaatg gaggggtgag aatatgttaa acaccataat

3961
taattcactg agtgcctatt atatgcaagg cactttgcta ggttctgtag gatatataaa

4021
gatttcttac tccatgttgg ggccaccttt ttcaaaccct gggcccagta aaatggaatt

4081
agatagtctc atagtatttg gttcaggtct acaagtatta attgagccaa ctatggacct

4141
ggcatgggag agggtacaag agaaattaga gatatgatcc cggacctaaa agagcttaat

4201
atctgaagaa tcacacttga gatgatggac aagcatccca gcaagtggag ttggaatgcc

4261
tgggggagct gcaggagaga cagagaagac agctctgttg gcatattgtc tttcttccca

4321
ccagcctgtg ctgtgggatc tgctccagag ggaaaagagt gtttgggccc tgcagattct

4381
agtgcaggta acaggtggag ggcacatggg tgggcbgggt gacagccatg gctggaggtc

4441
cctgccccgt gaggtgaggc catacccacc atgacctcct attcgcaggc gtacctgcat

4501
atgcccccag aaaacctcca gcagcbggtg ctttcagcag agagggaggc tgcacagggc

4561
ttcctgacac tcatgctgca ggggaagctg caggggaagc tgcaggtgag cactgagaaa

4621
ggggagcaag ggcacctgga gcctagtgtt cagagggctt gctttagtgg gaggaggaac

4681
tccagagagg aaatggcagg gatactgagc atctccagag gcagaatcca ttcctgtgcc

4741
cctacaggta ccaccatccg aggagcaggc cctgggtcgc ctgacagccc tgctgctcca

4801
gcggtaccca cgcctcacct cccagctctt cattgacctg tcaccactca tccctttctt

4861
ggctgtctct gacctgatgc gcttcccacc atccctgtta gccaacgaca gtgtgtaagg

4921
ttcttgcact actcctcctg ctcctgtcac ggtcaggcca accgcatcca cctggagcag

4981
ccccttccgg agctcctctc tgtttttttc tttcatgcca gataggcaat gtgccaacat

5041
cgtagcaagg tttgagagag gcacatctca cgcctgagtg tgaaaaccca atcattatgc

5101
taatgaacta caaaaggatc agagagctcc tctctattaa aaccagggag aggatgggcg

5161
tggtggctca tgcctgtaat cccagcacgt tgggagcccg aggcaggtgg atcactaggt

5221
ccgcctagtg agttcgagac cagcctggcc aatatggtga aaccctgtct ctattaaact

5281
acaaaaatta gccaggcatg gtggtgggcg cttgtagtcc cagttactct ggaggctgag

5341
gcaggaggat agcttgaacc tgggaggcag aggttgcagt gagccaagat cgtgccactg

5401
cactccagcc tgggtgacag agcgagactc cgtcttaaaa aaaacaaaaa acaaaacaaa

5461
acaaaaaaac agggagagtc tccttcctat ctagacagca gggctacaga gggtcagagg

5521
aaaacagttt ggaggaagac aaagggttaa gacccatgac tcctcgcagc ctggctgcca

5581
tccgggatta cagcccagga atgaggcctg aacagaagga ggctctggca aagcgactgc

5641
tggcccctga actgtttggg gaagtgcctg cctggcccca ggagctgctg tgggcagtgc

5701
tgcccctgct cccccacctc cctctggaga actttttgca gctcagccct caccaggtat

5761
gagaatcatc ttctttactt gactggccca tcttctgcta gtggggacaa agagtcaatg

5821
gcatgtctct cagtggcccc tccctgcaag aaccctatag tgaccccagt gcgagctaac

5881
cttccccatc tcagatccag gccctggagg atagctggcc agcagcaggt ctggggccag

5941
ggcatgcccg ccatgtgctg cgcagcctgg taaaccagag tgtccaggat ggtgaggagc

6001
aggtacgcag gtgagttgtt gtgggatcag taaccaaggc aagagtggaa gaggtagaga

6061
gaggaaggca cagcbgtcac gcbgggtcgg tgttctagga agaaaggggc aagagagtag

6121
gcagtggcct caggcagcat agagttccag gagagaggtc tatagatggt gcccctgtgt

6181
agtggtgtag tgtcagagtg cccagtgtat gtacccatac catctgctgc caggcctgcc

6241
ttagtgctag tcttggggac cacacaaagg tcagcttcat gccctcctca ggcttgggcc

6301
cctcgcctgt ttcctgagcc ctgaggagct gcagagccta gtgcccctga gtgatccaac

6361
ggggccagta gaacgggggc tgctggaatg tgcagccaat gggaccctca gcccagaagg

6421
acgggtgagc ccctcagcac aagcctacaa gactttaggc ttcccctggg tctgtgtgga

6481
tggctttccc attgtgtcaa cttgagcaca gtggtgccag cccccatccc acttttgcaa

6541
cctccattcc ttactccatg gccattctta cctgttacca cctcttcctg gcccttctct

6601
atctggtctg tagcacccca aacataccct ttgccatttt gaacctaatc tactccagtc

6661
caatccctag ttccaaaccc tagcccaggc cctgggaaat tcagatgtgg gattagagag

6721
gaagttcaag gttcatctgt cttttctctc cagtcctaaa ccttctttgg ttacaggtgg

6781
catatgaact tctgggtgtg ttgcgctcat ctggaggagc ggtgctgagc ccccgggagc

6841
tgcgggtctg ggcccctctc ttctctcagc tgggcctccg cttccttcag gagctgtcag

6901
agccccagct tagagccatg cttcctgtcc tgcagggaac tagtgttaca cctgctcagg

6961
tttgcctgtc tcactccctg gcatgtaccc tccatccccg cttgagcccc agtcaagaga

7021
atcccattca gggataaaag cagcccctcc tttccctggg tgaacagtag aggtaaactc

7081
tgtctgcagg aggacgcctt cattcccttt cctcagatca agaagggacc tgagtcactg

7141
aggatggtta ctggggatgg ttaagaggca gcgggaagtt ttggagggtt tgccttagga

7201
acccacttag gacctggctg ctgggtcctg agagcbgttg ttttcggtcc catcccaaca

7261
caggcbgtcc tgctgcttgg acggctcctt cctaggcacg atgtgagtag cagcaacttc

7321
tcagcctccc gccagaggtc tctatcctct tttaacctgg ctcctgcatc tgcccctcct

7381
ctctctccgc tcccctcata cttactgcct tgctgcattg tgattgttgt cttccccaac

7441
acccttccct tcttcttcag gcctcttgtc tctcttgctc tttagctatc cctggaggaa

7501
ctctgctcct tgcaccttct gctaccaggc ctcagccccc agacactcca ggccatccct

7561
aggcgagtcc tggtcggggc ttgttcctgc ctggcccctg aactgtcacg cctctcagcc

7621
tgccagaccg cagcactgct gcagaccttt cgggtatgag agtggcaagg aggatgagat

7681
aatcagggat accggctctt tctggttggg aggaaggcat cttccctgag gccagggaag

7741
gcctttcata cctccccact tacacacaca cacacacaca cacacacaca accaattctc

7801
atgcaggtta aagatggtgt taaaaatatg ggtacaacag gtgcbggtcc agctgtgtgc

7861
atccctggtc aggtaagtgt gagatctccc aactgagctc ctctccccat tctggggcag

7921
tttcatatgg ctggtgctac ctcccacact accctgcagt ggccctgaga gttctggtta

7981
gctctgtgcc cattagcagc cctccccagt gccagatgca ggacagcatg atccactcac

8041
attgtcctag actaatgtca aagctggaag ggcctgagaa atcttccagg ccacccaccc

8101
tgctttcaga tgaaaagacc aaggcbggga gaagctaagg gactttgttt gcctggtgcc

8161
taactagcag caacacttga ccacagcagc ctgcagtgtg aggctcttag gcgtttattg

8221
ctacagtggc aaatgccatt ccacttctgt cctagctttg gtccctttcc acccccatgg

8281
ttccttttct ctgagtgcta agtacagact ctctcaccta tcactacact gctataccca

8341
tcaccgccag cagcctattc ccaccacctg gccagactgc ctgcttcccc tgctcccatt

8401
aaagctgcta caactggatt ccttggctct tctggcaaat cgaagacgct actgggagct

8461
gccctggtct gagcagcagg taattctccc cacttaattt cagaacttcc tccctcaatg

8521
tagtctacct tctttaccta tcccttagcc ctatttggcc agcttatccc tactatcctt

8581
tatttgattg tttgagatac agtctcactc tgttgcccag gctgcagtgc agtggcatga

8641
tcagagttcg ctgtaacctc aaactcatga gctcaggcaa tctttctgcc tcagcctcct

8701
gaatagctag gatgacaggt ggttaccacc atgcctggct aatttttaaa tttttttttt

8761
gttttttgag atgaagtctt gctctgtcac ccaggcttga gtacagtggc acaagcttgg

8821
ctcactgcaa cctctgtctc ccgggttcaa gcgattctcc tgcctcagcc tcccgagtag

8881
ctgggactac aggcactccc cacaatgccc ggctaatttt ttttttgttt tagtagagac

8941
agggtttcac catattggcc aggctggtct cgaactgctg accttgtgat ctgcctgcct

9001
ctgcctctca aagtgctggg attacaggtg tgagccacca tgcccggcca atttttaaat

9061
tttttgtaga gacagacaat acaaaaatgt ggacactatg tggagacact atgttgaggt

9121
actatgctgt ccagattggt cttgaactcc tggcctcaag caatcctcct gccttggcct

9181
cccaaagtgc tgggattaca gacctgagcc actgcaccca gccccctagt atcccttata

9241
atgtgacttg cttttctttt tctttctcct tcccttttct ttcatttctt tctcactctc

9301
gagagaagag tgggcatctg ggagagtggg aggctggtgg gtcccacaga gtgaggaggc

9361
aggactgggt ccaaggcagt cctgcctctc cactctaggg ggtatccttg gacagtgtct

9421
cttctgggaa ggggctcgtc tttctttctc ttgtaggcac agtttctctg gaagaagatg

9481
caagtaccca ccaacctgac cctcaggaat ctacagtgag taacttgtgt tgagcagtgc

9541
gctgaattcg accaacattt ttttgagtgc ttactatgtg ccaggcacca tatgatatgg

9601
aatgggggat atagggatga atgatgcata gtccctgcct cgtggacgtt ctcctagcac

9661
ctccctttgc cctcctttcc ttccacagtg ccatgcctat cctgactaga gccaaaggac

9721
tcagaaaacc tggattcagg ttccagtcct gtcacctact tgtcctcttg ggcaagtcat

9781
ttaacgtccc tgtgtcagtt ttcccttctt taaatgagaa ttacaatggc accagcctca

9841
taggtagtta ctgtgaagat taaatgaggt aggtcatgta agatatttaa cacagtgttt

9901
ggtccattgt aaagttccag tagtcatttg ctactgttag tttacttcag gatgacttca

9961
gaggcactgg ccaagcaaga ataaatagga ataagaaggt atcactttac ttatacccac

10021
attagaagaa caatgggctt cagaatcttt tttttttttt ttttcgagac agtcttgctc

10081
tgttgcccag gctggagtgc agtggcgcga tttcggctca ctgcaacctc tgcctcccag

10141
gttcaagcga ttctcctgtc tcagcctctg gagtagctgg gattacagga atgtgccacc

10201
atacccagct aatttttgta tttttagtag agatggggtt tcaccatttt ggccaggctg

10261
gtctcaaact cctgacctca ggtgatccac ccgcctcagc ctcccaaggg cttcagaatc

10321
taagacatgt ctctagtttc agtttaccac atttctagca gaatgatgtt gggaatgtca

10381
cctgacttcc ataaatcctt attttctcct ctgataaaca gcagtgatgt tatggggagc

10441
tgatgagata tctatgtaaa aacatttctc aaaccataaa ttacggtgga tgaacatctg

10501
tacttgtgtt gagagtactg atatcaagga gcaaacaggc tgttgtatgt gttgaatgag

10561
cctctcccca ctcacacacc cacagggctc tgggcaccct ggcaggaggc atgtcctgtg

10621
agtttctgca gcagatcaac tccatggtag acttccttga agtggtgcac atgatctatc

10681
agctgcccac tagagttcga gggagcctgg tgagagggga tgcctggact ttagtgggag

10741
cagggaggct gggaccctag gtatagaacc cagctcctat gttctgctct ggcctcactc

10801
tgcttcccta cagagggcct gtatctgggc agagctacag cggaggatgg caatgccaga

10861
accagaatgg acaactgtag ggccagaact gaacgggctg gatagcaagc tactcctgga

10921
cttaccgtaa gtactgcagc tagagatatt ggcccctcag aaagctcaat ctggggtgaa

10981
gatctgccct tagggaatgc cctggaggag gtagtttttc tgtctggtag ttccctgaca

11041
taatttatag cccaaagcag aggattttat tcaaagttgc tctatgtatt gactggttcc

11101
cagaatatgc tccagcacag ggcagctgag ggtggcaaca ctgtattgaa gcctgccaag

11161
taatcttaca ataacctagt ccacattaat tgagattgag acagagcatc tgaagtgagg

11221
gaggcaatgc tccaaatctg ccccagagga ttgtagtttg ctcagggcac tgtgttctta

11281
gtgcattcag aggagtggat cgagagaaaa atatatgaaa aatgtgataa ataccttcaa

11341
atacctgagg ggctatcaag tagaaattag attgtcatat ttatgagtgg ccccattggg

11401
caagactaag agtagttaac ggagatcaga tttttacata gtataagaaa aactaaggta

11461
gtgagttcct ggtccttgga gcbgttcgag cctaagccag atggccccat ggcaggaatg

11521
ttgtagagca cgttcatata caggttgtgg gaagaaaagg ctataggaac ccaaggctcc

11581
tccctaccca tggagaaatt tattagtatg ttactcatat gctgcttttc tcattttacc

11641
cctaccacca ccccgttgcc atccgcactg taagtcagga taggaaaatg ctggtgttac

11701
agtcttcctg gggaatatgg agctgaagtg gagtaaaagc agttgacttc attcttactt

11761
ttttcttttt cttttttttt ttttttttga gacagagttt tgcbgtgtca ccaaggctgg

11821
agtgcagtga cgtgatctcg gctcactgca acctccatct tccaggttca agcaattctc

11881
ctgcctcagt ctcccgagta gcbgggactg taggtgtgca ccaccatgcc aggctaattt

11941
ttgtatttgt tgtagggacg agctttcacc atgttggcca ggcbggtctt gaactcctgg

12001
cttcaagtga tctgcccacc tcggcttccc aacattctta tatttttata ggcctttcca

12061
cagatttcag ctcttgtatg acttagccca gttccagaac tggtaatcct aggtagggta

12121
caggttatca cctctgattt cgggtaaaag ggatttattt atttatttgt ttatttattt

12181
atatttttga gacagagtct cgctctgtca cccaggctgg agtgcaatgg tgccatctcg

12241
gctcactgca acctctccct ctggggttca agcacttctg cctcagcctc ctgagtagct

12301
gggattacag gcgcgtgcca ccacacccgg ctaatttttg catttttagt agagacgggg

12361
tttcaccatg ttgctcaggg tggtctcgaa tttctgaccc tgtgatctgc ctgcctcggc

12421
ctcccaaagt gcbgggatta caggcatgag ccactgcgtc cggcctgttt ttactttttt

12481
ttaatgccat tcagatctgt ttaaatatgt gggttctgtg agataattta gaatcccaag

12541
gttacagatg aggtgaaaga tcctagacca tgcatcaaaa aacttgagtt tctcatttgt

12601
gaaagaagga taagagaaac acctattttg tctgggtgca gtggctcatg cctataatcc

12661
cagcatttgg ggaggccaag gtgggtggat cacggaggtc aggtgttcaa gaccagactg

12721
gccaacatgg caaaacacca tctctactaa aaatacaaaa gttagcbggg cgtggtggca

12781
cgtgcgtgta attccagcta ttcgggaggc tgaggcacga gaattgcttg aacctgggag

12841
gtgcgggttg cagtgaactg agatcgcagc accactgtgc tccagcctga gtgatggagt

12901
gaggccaggt cttgttgtag gatcaaatga gataacacct gaaagaactt tgtaaattgt

12961
atagcacgta caaacaagaa gggacctctt cacaagcaga ggaagggtgg tcctgtggaa

13021
aaaaacggga attgggagtg agagacctca acatttgatc tctgtgaacc tcagtttttt

13081
aatctataaa atggggaaat gttaatggta cttaatattt ggagcttttg agtccattag

13141
atcaggtagg attgttcgtt attttttttt tttaggaaga ctagaaatat gttgctccct

13201
ttttctcccc cactcaagct tgatggtggg aattggccct ggagcbgttt actgtcagtt

13261
cctgtccagc ttcactaaat ttggtctggg gtcacatctt agcbggggac tgtggggttc

13321
tgtggtccct tctcgacttg gcccagctcc acttgaatga tattgttgtc aaattgctat

13381
aatagaatcc agttgatgga cagactatcc aatgaatcca ttatgttggt ggtggagctg

13441
gtgcaaagag ctccagagca gctgctggca ctgacccccc tccaccaggc agccctggca

13501
gagagggcac tacaaaacct ggtaagagtc caccctacca gactcagatt tgctgccctg

13561
ggcaattctt gctcctcaga caatgctctc tgactgtcct ccaaccctct acttcttgct

13621
ttcttgctgc caaacaggtt cctgtctaca aggcctggcc cgttttgcct ctgggttctg

13681
ttccttgata atatgcttca cgttacttgt ccatacctct tggagtccga gaaatctctt

13741
ggagtccacc tctcagtctt tctgcctgct cctatctggt ctcattgctt aagaaagtga

13801
acaaaggtag tgagcatcat agggtgctga gttgggagca ggagggaggg aaggtcaggg

13861
ggcttggtgt cttgatcaag gtgtctggta ttctgagtca gaagtgcatt gtccaagttc

13921
tgatgctctt ctccaggctc caaaggagac tccagtctca ggggaagtgc tggagacctt

13981
aggccctttg gttggattcc tggggacaga gagcacacga cagatccccc tacagatcct

14041
gcbgtcccat ctcagtcagc tgtaaggctt ctgcctagga gagacatttg ccacagagct

14101
gggatggctg ctattgcagg agtctgttct tgggtatgga tcttcgagaa cttcagattc

14161
taactcattc tatacccagt ccctcagcca ccatcatcag tggcagcctg ttccatattc

14221
ctaagggccc ttggagccct gtgtccgaaa tcctagcatg tcctcttttc cccttccttt

14281
tcctcacagt tccctcagct ccccagcccc cgattttctt cctgtcccca ggaaaccaga

14341
gttgtggagc caggatgaag tagagcaagc tggacgccta gtattcactc tgtctactga

14401
ggcaatttcc ttgatcccca gggtgagatg aaggaagaag ggaagggagt aaatgcatag

14461
aggggactgg tgagctggtt atggggaccc gtggccaacg agggcaaagg atatgaagcc

14521
tagatctggg gggatactgc gaaacagaga caggactttg gacttatagc tatagcagca

14581
ggtcctgatc tgtccagatc tccccactct ccttctacct tctcatgcag gaggccttgg

14641
gtccagagac cctggagcgg cttctagaaa agcagcagag ctgggagcag agcagagttg

14701
gacagctgtg tagggggcca cagcttgctg ccaagaaagc agccctggta gcaggggtgg

14761
tgcgaccagc tgctgaggat cttccaggtg aaactaccca aatacttata tgtccagcag

14821
gatgtacagg gagtatcaaa cggtctgggt tctacatgtg cttttctctg ggactgggtt

14881
ttctaattta taaagcaaag agtttagagg gatgatcttc aagtctcgtc tagttctaaa

14941
attctatagc tctgggagtg tgtaaactat taagttttcc tttagcccag aacttccatt

15001
ttcctgctgt cttgtctctt taaacagctg actcagctct agctcggcta agtgtggagc

15061
tctctgctgg ggagatccct cgaaggagac attgtgaggc tagagaactg gtttcaaatt

15121
cagctctgcc atgaaatccc tgaccaacat cctcagtctt ccatctataa aatgagggac

15181
ttggcatctc caatcacttc ttgttcaatt cacttctaag ccctatacat cttaacctgt

15241
aatactccct cgatccctac ttcccacagt gctccatcct ccaaaggttg gaagagtcat

15301
tccatctaca gatacctcct ggccctgcct tcccccttca gaacctgtgc caaattgtgc

15361
agatgtacga gggacattcc cagcagcctg ctctgcaacc cagattgctg agatggagct

15421
ctcagacttt aaggactgcc tgacactatt tgcaggagac ccaggacttg ggcctgagga

15481
accacgggca gccatgggca aagcaaaatg ggtcagggac ggagagccaa ctgaggttgg

15541
ccatgaggaa gctgtgtggg tgtgatgtag gacacgaaga gaatagagag ttggatgaga

15601
ggtgggggaa gcagaagata aaagagttag aagatttggg tcacaagtag aaggtgagga

15661
gagataaata ttgaggaaag agagctacta taatgaatag agggactaaa gcagtgatta

15721
ccaaatttta atgcatatca caatcatcaa gggaacagat ttttttcttt tttctttttt

15781
tttctttctt aaaaaataat ggcatacttc atgaatttgt gtgttatcct tgcgcaggcg

15841
ccatgctaat ctctgtatca ttccaatttt tttttgtata tgtgctgctg aaccgagcac

15901
gggaacagtg ccaatgctgg attaccatgc tagactgact taataaaaac ctttgcggag

15961
gctggacgga gtggctcgtg cctgtaatca cagcactttg ggaggctgag gcaggtggat

16021
tgcttgagcc caggagtttg agaccagact gggcaacatg gtgaagccct gtctctacta

16081
aaaatagaaa aaaaattagc tgggtgtggc ggcacatgcc tgtaatccca gctactcagg

16141
aggcbggggt aggagaatcc cctgagcgca ggaggtggag ggtgcaatga gccaagatca

16201
caccactgca ctccagcctg ggtgtcagag caagaccctg tctcataaat taaaaaataa

16261
gcctctggga gaaagtctag acatctgcat ctgctttttt tttttttttt ttttttgaga

16321
cacagtctca ctctgtcacc cagcatccag gctggagtgc ggtggtgtga tcttggctca

16381
ctgtaacctc tacatcctgg gctcaaacga tcctcctgcc tcagcctctc gagaagctgg

16441
gactacaggt gcacaccact acacctggct aatttttgta tttttggtag agatgaggtt

16501
tcgcbgtgtt gcccaggatg gtcttgaact cctgggctca agcattcctc ccacctcagc

16561
ctcccaaagt gcbgggatta cagctgtgag ccactgtgct gggccccagg catctgcatt

16621
ttaataagcg tctctgtgtc tgatgcacat aaaagtgtgg aactcatgga ctagagttag

16681
tttgctcttc ttttccactg attgtaatgt ctttcaaaac accttagagg aactgtaagg

16741
caacggtctc attttatagt ggaggaaacc aaagaaaagg caagtgactt gcctagagtt

16801
atacagctaa ggtcagaggc aagacttaaa acccagcatt ctgactccca atctactggt

16861
tttccactca cattgttcct ctctttctcc tagttgtggg gtcccccccg gggatttggt

16921
cctgagcaga tcctgcagct cggtagactc ttaataggtc tgggagatca ggaactacag

16981
gagctgatcc tagtggactg gggagtgctg agcaccctgg ggcagataga tggctggagc

17041
tccactcagg taacactttt actcctccct accgcttccc aaacacccat cccacagacc

17101
cagccctata gatcatctaa agcccaagga attttttcct gtgaccctac ctggtcattc

17161
tttctgtctt ttgttaatat cccatactag tgaccttcag gactcttgat ttattcactc

17221
tgaggccctg gacacataat actgtctcct acctcttttc ctggaggctt cctctttttc

17281
tttccttttc ttttctgagt cctcagcctt ccccatgact ccttaggtct taatagtaac

17341
agaatataac ccagtaacac ctatcacttc cctgtccatt aattctccat aactttcctc

17401
cttcccctct tctcccaccc cccaccccag ctccgcattg tggtctccag tttcctacgg

17461
cagagtggtc ggcatgtgag ccacctggac ttcgttcatc tgacagcgct gggttatact

17521
ctctgtggac tgcggccaga ggagctccag cacatcagca gttgggagtt taggtcattt

17581
gtgaaggggc tgagggtggt cgtgttcagg taaaggtgga cttgcbgggg aaaggaggat

17641
catgaagtta tagtcccatg gaggaaggga actcatttga agccatctct tcctttgtct

17701
catgaccaca gtccctttca ctgaagccga attcttcttc cttccttccc actgttctac

17761
agccaagcag ctctcttcct gggcaccctg catctgcagt gctctgagga acaactggag

17821
tttctggccc acctctttgt actgcctggt gggtttggcc caatcagtaa ctgggggcct

17881
gagatcttca ctgaaattgg caccatagca ggtggggagc tgggccactg ctggtgcaag

17941
ttggtttggt ttctatacca tgggtggact ggatggaaga ctgccctgca attcttcagg

18001
tgtgggcctg agagggtgtt taaataaggg gctagagaca tattggggaa ggtctatgat

18061
agggcacttt gggagtagtt agagaaggtc tataggtttg aagagaggga aggtcagtct

18121
aagacaatgt ttggatgcca cttgcttcaa cagcbgggat cccagacctg gctctttcag

18181
cactgctgcg gggacagatc cagggcgtta ctcctcttgc catttctgtc atccctcctc

18241
ctaaatttgc tgtaagtatt aatggactgg ggtgaccaca ggagagccag ggcccaatgg

18301
ggactacatg catgcactga ttcctacccc tgccctcagg tggtgtttag tcccatccaa

18361
ctatctagtc tcgccagtgc tcaggctgtg gcbgtcactc ctgagcaaat ggcctttctg

18421
agtcctgagc agcgacgagc agttgcatgg gcccaacatg agggaaagga gagcccagaa

18481
cagcaaggtg agttcccagc tgcacagctt gatcctccat ctcctgaccc agaatcaaac

18541
ccctaatttg gtgcbgtctg gctcttagag tgcacccagg gagatccctg gagtgaagga

18601
gtctacaggc agagcgctaa tttccaagta tcaatgctcc tggagagctg agttgtgata

18661
ttactcccat tccctgtcta ttataggtcg aagtacagcc tggggcctcc aggactggtc

18721
acgaccttcc tggtccctgg tattgactat cagcttcctt ggccacctgc tatgagcctg

18781
tctctacagt agaaggagat tgtggggaga gaaatcttaa gtcataatga ataaagtgca

18841
aacagaagtg catcctgatt attttcagaa gctgatgagg aata

Clarin 1 (CLRN1)

The CLRN1 gene encodes “clarin 1” (CLRN1), a protein that is expressed in hair cells of the inner ear (e.g., inner ear hair cells, outer ear hair cells) and in the retina.

The human CLRN1 gene is located on chromosome 3q25.1. It contains 7 exons encompassing ˜47 kilobases (kb) (Vastinsalo et al. (2011) Eur J Hum Genet 19(1): 30-35; NCBI Accession No. NG_009168.1).

Various mutations in the CLRN1 genes have been associated with Usher syndrome type III (e.g., Usher syndrome type IIIA (MIM #606397) (see, e.g., Fields et al. (2002) Am J Hum Genet 71: 607-617, and Joensuu et al. (2001) Am J Hum Genet 69: 673-684) and retinitis pigmentosa (see, e.g., Khan et al. (2011) Ophthalmology 118: 1444-1448). Usher syndrome type III-causing mutations have been predominantly found in exon 3 of CLRN1. Usher syndrome type III-deafness can be modeled by generating CLRN1-deficient mice (see, e.g., Geng et al. (2017) Sci Rep 7(1): 13480). Exemplary mutations CLRN1-associated with Usher syndrome type III include: T528G, M120K, M44K, N48K, and C40G.

Exemplary mutations CLRN1-associated with retinitis pigmentosa include L154W and P31L (see, e.g., Khan et al. (2011) Ophthalmology 118: 1444-1448).

Additional exemplary mutations in a CLRN1 gene that have been detected in subjects having hearing loss and methods of sequencing a nucleic acid encoding CLRN1 are described in, e.g., Fields et al. (2002) Am J Hum Genet 71: 607-617, Joensuu et al. (2001) Am J Hum Genet 69: 673-684, Adato et al. (2002) Europ J Hum Genet 10: 339-350, Aller et al. (2004), Clin Genet 66: 525-529. Methods of detecting mutations in a gene are well-known in the art. Non-limiting examples of such techniques include: real-time polymerase chain reaction (RT-PCR), PCR, sequencing, Southern blotting, and Northern blotting.

An exemplary human wildtype CLRN1 protein is or includes the sequence of SEQ ID NO: 39, SEQ ID NO: 41, SEQ ID NO: 43 and SEQ ID NO: 45. Non-limiting examples of nucleotide sequences encoding a wildtype CLRN1 protein are or include SEQ ID NO: 40, SEQ ID NO: 42, SEQ ID NO: 44 and SEQ ID NO: 46.

In some embodiments of any of the compositions described herein, the CLRN1 protein comprises a sequence that is at least 75% (e.g., at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%) identical to SEQ ID NO: 39.

Human Full-length Wildtype CLRN1 Protein Isoform D

(SEQ ID NO: 39)

MPSQQKKIIFCMAGVFSFACALGVVTALGTPLWIKATVLCKTGALLVNASGQELDKFMGEMQYGLFHGEGV

RQCGLGARPFRFSFFPDLLKAIPVSIHVNVILFSAILIVLTMVGTAFFMYNAFGKPFETLHGPLGLYLLSF

ISVALWLPATRHQAQGSCGCLVMILFASEVKIHHLSEKIANYKEGTYVYKTQSEKYTTSFWVIFFCFFVHF

LNGLLIRLAGFQFPFAKSKDAETTNVAADLMY

Human Wildtype CLRN1 Isoform D cDNA

(SEQ ID NO: 40)

atgccaagccaacagaagaaaatcattttttgcatggccggagtgttcagttttgcatgtgccctcggagt

tgtgacagccttggggacaccgttgtggatcaaagccactgtcctctgcaaaacgggagctctgctcgtca

atgcctcagggcaggagctggacaagtttatgggtgaaatgcagtacgggcttttccacggagagggtgtg

aggcagtgtgggttgggagcaaggccctttcggttctcattttttccagatttgctcaaagcaatcccagt

gagcatccacgtcaatgtcattctcttctctgccatccttattgtgttaaccatggtggggacagccttct

tcatgtacaatgcttttggaaaaccttttgaaactctgcatggtcccctagggctgtaccttttgagcttc

atttcagttgccctttggctgccagctaccaggcaccaggctcaaggctcctgtggctgtcttgtcatgat

attgtttgcctctgaagtgaaaatccatcacctctcagaaaaaattgcaaattataaagaagggacttatg

tctacaaaacgcaaagtgaaaaatataccacctcattctgggtcattttcttttgcttttttgttcatttt

ctgaatgggctcctaatacgacttgctggatttcagttcccttttgcaaaatctaaagacgcagaaacaac

taatgtagctgcagatctaatgtactga

Human Full-length Wildtype CLRN1 Protein Isoform A

(SEQ ID NO: 41)

MPSQQKKIIFCMAGVFSFACALGVVTALGTPLWIKATVLCKTGALLVNASGQELDKFMGEMQYGLFHGEGV

RQCGLGARPFRFSFFPDLLKAIPVSIHVNVILFSAILIVLTMVGTAFFMYNAFGKPFETLHGPLGLYLLSF

ISGSCGCLVMILFASEVKIHHLSEKIANYKEGTYVYKTQSEKYTTSFWVIFFCFFVHFLNGLLIRLAGFQF

PFAKSKDAETTNVAADLMY

Human Wildtype CLRN1 Isoform A cDNA

(SEQ ID NO: 42)

atgccaagccaacagaagaaaatcattttttgcatggccggagtgttcagttttgcatgtgccctcggagt

tgtgacagccttggggacaccgttgtggatcaaagccactgtcctctgcaaaacgggagctctgctcgtca

atgcctcagggcaggagctggacaagtttatgggtgaaatgcagtacgggcttttccacggagagggtgtg

aggcagtgtgggttgggagcaaggccctttcggttctcattttttccagatttgctcaaagcaatcccagt

gagcatccacgtcaatgtcattctcttctctgccatccttattgtgttaaccatggtggggacagccttct

tcatgtacaatgcttttggaaaaccttttgaaactctgcatggtcccctagggctgtaccttttgagcttc

atttcaggctcctgtggctgtcttgtcatgatattgtttgcctctgaagtgaaaatccatcacctctcaga

aaaaattgcaaattataaagaagggacttatgtctacaaaacgcaaagtgaaaaatataccacctcattct

gggtcattttcttttgcttttttgttcattttctgaatgggctcctaatacgacttgctggatttcagttc

ccttttgcaaaatctaaagacgcagaaacaactaatgtagctgcagatctaatgtactga

Human Full-length Wildtype CLRN1 Protein Isoform C

(SEQ ID NO: 43)

MQALQQQPVFPDLLKAIPVSIHVNVILFSAILIVLTMVGTAFFMYNAFGKPFETLHGPLGLYLLSFISGSC

GCLVMILFASEVKIHHLSEKIANYKEGTYVYKTQSEKYTTSFWLTKGHS

Human Wildtype CLRN1 Isoform C cDNA

(SEQ ID NO: 44)

atgcaggccctgcagcagcaaccagtttttccagatttgctcaaagcaatcccagtgagcatccacgtcaa

tgtcattctcttctctgccatccttattgtgttaaccatggtggggacagccttcttcatgtacaatgctt

ttggaaaaccttttgaaactctgcatggtcccctagggctgtaccttttgagcttcatttcaggctcctgt

ggctgtcttgtcatgatattgtttgcctctgaagtgaaaatccatcacctctcagaaaaaattgcaaatta

taaagaagggacttatgtctacaaaacgcaaagtgaaaaatataccacctcattctggctgactaaaggcc

acagctga

Human Full-length Wildtype CLRN1 Protein Isoform E

(SEQ ID NO: 45)

MPSQQKKIIFCMAGVFSFACALGVVTALGTPLWIKATVLCKTGALLVNASGQELDKFMGEMQYGLFHGEGV

RQCGLGARPFRFSCYFLDPFMGLPTGVPHLLSLPCSTSCRREHTSERVQEPAGCFSAVRSKLHAGPAAATS

FSRFAQSNPSEHPRQCHSLLCHPYCVNHGGDSLLHVQCFWKTF

Human Wildtype CLRN1 Isoform E cDNA

(SEQ ID NO: 46)

atgccaagccaacagaagaaaatcattttttgcatggccggagtgttcagttttgcatgtgccctcggagt

tgtgacagccttggggacaccgttgtggatcaaagccactgtcctctgcaaaacgggagctctgctcgtca

atgcctcagggcaggagctggacaagtttatgggtgaaatgcagtacgggcttttccacggagagggtgtg

aggcagtgtgggttgggagcaaggccctttcggttctcatgctattttcttgaccccttcatgggactccc

aacaggggtaccccatttactcagcctgccctgctcaacctcttgcaggagggagcacacgagtgaacgag

tgcaggaaccagctggctgctttagtgctgtgaggagtaaactccatgcaggccctgcagcagcaaccagt

ttttccagatttgctcaaagcaatcccagtgagcatccacgtcaatgtcattctcttctctgccatcctta

ttgtgttaaccatggtggggacagccttcttcatgtacaatgcttttggaaaaccttttga

Human Wildtype CLRN1 Genomic sequence (NCBI Accession No. NG_009168.1)

(SEQ ID NO: 47)

1
aggagatact tgaaggcagt ttgaaagact tgttttacag attcttagtc caaagatttc

61
caattaggga gaagaagcag cagaaaagga gaaaagccaa gtatgagtga tgatgaggcc

121
ttcatctact gacatttaac ctggcgagaa ccgtcgatgg tgaagttgcc ttttcagctg

181
ggagctgtcc gttcagcttc cgtaataaat gcagtcaaag aggcagtccc ttcccattgc

241
tcacaaaggt cttgtttttg aacctcgccc tcacagaagc cgtttctcat catgccaagc

301
caacagaaga aaatcatttt ttgcatggcc ggagtgttca gttttgcatg tgccctcgga

361
gttgtgacag ccttggggac accgttgtgg atcaaagcca ctgtcctctg caaaacggga

421
gctctgctcg tcaatgcctc agggcaggag ctggacaagt ttatgggtga aatgcagtac

481
gggcttttcc acggagaggg tgtgaggcag tgtgggttgg gagcaaggcc ctttcggttc

541
tcatgtaagt agcaattgca tttgagttat ttaatgcttt aggcagactc ttcccagtgt

601
tgcgaggaat tatatttgag aattttgccg tgtttactgc aggacttttt aaatcggtgt

661
gaaccatatg aaaaacctat gactctgagc aatttcttct tcctagtttt tattatttta

721
tacttgcttt ttattataat atagagttaa ttcattgtta cataattaag gtttttggaa

781
atattggcaa ttaagatgct taagtattaa tatttatgta aaaaattatg gagtcttttt

841
aaaaaagtaa acttggggaa ataggaaagc tgtaaagaat gatctttatg ctttttgttc

901
tttataaaaa gaaccaaggt catgggctcc gtatttaacc aggttgccac ctttctcatg

961
attttgtttc ctgctcccca ctccctccca ttattcctgc taagaccttt cctgctgcta

1021
aatattcagt tttcattttt aactaatttg gaatcatttg gctatagaaa tttaaaatga

1081
tctgcbgtgc taactgggaa agaaatggat gcctatttag tatagaacat tttaaactga

1141
ttgacctgca aatcatgtag agaatatgag agagattttc ttgttgtgat ttttgtgaaa

1201
tggaagtgta atccacagta tttataacct gtttatctta agaagagaat ttttaaaaat

1261
taccatgtga ataggcaact cattaaatga aaattaatag gaagtcattt gttatatctc

1321
ttacaacaca cattcagaag ttattattat ttcagaaggg ctggtttgga acaaccttat

1381
gaagacacag tcagtaaatt actgcataaa tcactcttca ggaaaggagg ttaccaactg

1441
aagcatttaa aatgaattat tattttgccc aggttttttt tttctttcta gtataggtag

1501
aaggctaaat taattgaatt tattattaac atatgcagtg cctaattaaa tttcagtgct

1561
ggtctattta tatttctgca acattcctta tatcttctta gcagtcattg gacaccaacc

1621
ttcagctcac ataggttact aagtgatatg aattttcata gggctccaga aaatttccaa

1681
gaattggttg ttagcttttt aattgatgaa gtggatacca gttcttttca ctgaatggct

1741
tttattcatt aaggtaatgg ggcbgttaga gttgcttagt tttcctgggg aaggggaagg

1801
aagaaaacaa agcagaatgt catgtgatat gcaactgtat taaaaaaccg aaaaggaaaa

1861
aagttgagag agatgattta accgtgagtc accggcagcc aaagcgtgag taaagcttct

1921
cacagatgaa tttagacaaa agcggagaag gtactggtga attttctgga gcctttacat

1981
tttctacagt gaaatggaga taaactttac tcatgccata ggacatgttt caaaacaata

2041
ataagatgtt ttctgaacac ttactacata ctaagcactt tatatgcttt gtctcattta

2101
atccttacac agccacattc ttctggggtt tagcgaatga tttttgtggt tgtgtcctat

2161
gcttgtcctg tctaaggatg aagttgttct aattgggtgc ccctcctttt gctttctgtg

2221
aggacttgca gaactggtgg ggtttaaaca gtaccctcac ttatctcaca gaatttcatt

2281
agctcccaga tacccctgac attctccccc tagcctagtg aagaaaatct tccatttact

2341
tgttcattct gcagtgacag ctccatcaat atacaataga ctatacatat taagtgtact

2401
gtatatacta tacatgttaa aaatctcatt cattttggtg aggcccagct aagaatactt

2461
acagtagagc tttttttttt ttcctaagca taaaagtatc tttttcaatg cagcatgaga

2521
cagagttggg aaaaccaaaa taaatagatc caatggactc cccaaagagg ataatattca

2581
tttaaataaa cacccctctc agtgttaaaa ctttctaatc aacatgcctt tgggacacat

2641
tgcaccctca aagtttacac tcccattgca acgcagcttt gtggttcacg ttttttccat

2701
tcagaatgtc attaccctgt caatgatgtt tcatcaacgt ttgcttggat gagaatcctc

2761
tgatattctt cctgatagaa atgtataagc cctgttcata taaatgaata aaagatctaa

2821
ccttactttc tcagtagtgg cttccttgga gcaaaaagca gggacctcca gagagctcag

2881
gtggatgact cttttctgtt tcttccagag ctcaacttac aattagtgca caattcattt

2941
cccagaatgt cttctttctt attgtgcctt tagaaagtta ttaagcaaac atttgaattc

3001
acagaatctt accagtgtaa gaggaatgga aaaggtaact tatcaaggta acaatcactt

3061
cgtggccagt tttttcggct cactgcaact acccctcctg ggttcaagcg attctcctgc

3121
ctcagcctcc caagtagctg ggactacagg cgtgcaccac catgcccagc taattttttt

3181
tttgtatttt tagtaaagac agggtttcac catgbgggcc aggctggtct catggcaagt

3241
tttctttgtg ttgtcatgtt attatcaatt aataggaatt tatatttcag ttctgttagg

3301
tggataaaca ctattttgca tacctaaatg tttcatttat atcagcactg gccaataaaa

3361
atatactata agcaggccgg gtgcagtggc tcacgcctgt aatcccaact tttgggaggc

3421
caacactttg ggaggacaca gggtcaggag atcgagacca tcctggctaa cctggtgaaa

3481
tcccgtctct actaaaaata caaaaaatta gccgggcgtg gcgggggcgc ctgtagtccc

3541
agctacttgg gaggctgagg caggagaatg gcacgaaccc gggaggtgga gcttgcagtg

3601
agccgagatc tcgccactgc actccagcct tggtgacaga gcaagactct gtctcaaaaa

3661
aaaaaaaaaa aaaaaaaaaa aaaaaatata tatatatata tatatattac aagccacaag

3721
ccacatatgt acttttaaat gtcctagtag ccatattaga aaacaaaagt aaaaaggaat

3781
agatgaaatt aattttaatg atttttttaa acccaagata tccaaaatat tatcatttta

3841
acatataatt aaaaatttat tgagatgttt tacattgttt ttttttttct tgacgctgtc

3901
ttggaaatct agagtgtatt ttacatttac attacatcta attcagtcta gccacatttc

3961
acatgctcat ttttttgtgt gtggttttat ggagcagaga gtttaatagg caagaaagaa

4021
aagagaaggc agaagaaaat ggctcccctg tacagagacg cgggggtggg gcgctccaaa

4081
gccaaaagag gaggtcccta agtatggtag acaccagcca ggaatatatg cagtgtctgg

4141
aggaggggat gtctgatttg catagggtca catgctcatt tttatggcta ctgtattggt

4201
cagtacagat ttagatgggg atttgctctg aacaagttgg tgattgatgg tgttcatatt

4261
ttaattgaat ttttcctggg ttctgctgta cacttgtatg tgtgttagtt tcatgtgcaa

4321
tgcttgtgtc acttttaaaa cccagatata tggcataaca tgagaatgaa aaatggacca

4381
gaaaaatagt ttggcaatgt agtcatgttt gttcctatta aatgttccct attgaccact

4441
ctatctcttt taattataac aagaatctgc cctgccagca tgcccagtta cgctgggaaa

4501
acttctgcct catttactct ggctgattct catccactta tgggtcagtg gttcattttc

4561
tagaggtcac cagcattcat acctagcata caatttcatt cattataatg aaggaatgtt

4621
ttcccttcaa agagacacaa ctagtgggct taatttttct tgatatgtca cctgtaaaat

4681
tttaatgatg atgtttaaac tctaaatgta gccatcaaga caaaaactgc aaattttgag

4741
cctcagtgtg tgtgggtggg tttctgtttc ggtaatttga aacattgcag aatatcatca

4801
aaatatgata cccaagaatc atatggtatc aatcattcct agatatactg atctattcat

4861
tgccaagata gttcaatgag ctggcaaaaa catatggaat tattttctta aaatgtgaaa

4921
aataaaattt aaccaatcat gtatcacagc ttgcaacttt agtcatactt tgaaaagcat

4981
tttaatttgg acctcatgat tgaaaattta taaaaagctg aacagaaatt agttcacttc

5041
atattttaga aaagcagagt ttctttacta aatgaggcat ttgacccaaa ttggagagaa

5101
aatgttgaaa ctacttctgt gagcaagcag gtggcttctc aaacacatgt tgggatgaaa

5161
tggttgggcc tcagggtctc agtgcctgtc actgagagtt ggcactctct atctccatgg

5221
tctcctccaa gtgtgactct tgtctcttgc tgacctgacc tgccccaagt gactcactgg

5281
tcatgaccct gcacaccttg cgtctctcct atcaccctgc cgatggcaga gctacaaagg

5341
tctttgatgt agctctgtct gatatcctgt gtttccccct atggtctgtg tggaagcagg

5401
tatgggggtg tgtaaagggg aagcctatga agttcatctg caaagactac ctggttaggg

5461
gaggagagga agaagctata tgcaccattt caccagcaag catgggctct tctgcctttt

5521
agcttagggg tcctgttgtc tagtctcact cacctattaa aacagtccag caaatagagg

5581
ttttgtttac ctcccattaa aaaaaaagca attaatggaa tagaagataa taatgtatga

5641
gaagcactat tgtgaaagaa aaaccttcaa cttctctcag ccaaataatt gcttcctcct

5701
ctgtccttcc cagaccttga tgtttgctct attatttcaa aacaactata ttataaatat

5761
ttgagaatgt gtatttccct gcaaggagat cttaatcccc aagaaggcag gagctgtgta

5821
ttattcatcc cagtgctcct tcaaaccagg gcctcagaca gtgcatggcc caaagaggta

5881
cttaataaac gtttggtaaa ctgacactat tgaaattaag caacctggat ttgaggtggg

5941
tctctgccac tcacaagaga ttacgctttg agaaaattcc atcacttcat tgattttcag

6001
ttcttgcatc tgtatatggg agacgatact aggtgatttc tgacatctct caccgtttaa

6061
atgctctgtg atctatacaa cgaggggctc gcbgttctag acaagttcct tccagcttta

6121
cagttgcata acccttctaa tcttagtcac atgatgactc cactgacaga tttttggcca

6181
ccatcattag acatgctgag ttacgtgtgc ctttgctctg atcctcaaaa ctcatgattt

6241
ttaaagtttt ctgaaatatc taccatttat caggatccag atggatttca tgaccaaagt

6301
ggatgtttct tttctctccc attacaatct tttacttttt gtgtgggaaa ttgcatgtta

6361
aagaaaggga aattgaagaa tgggatgctt tggaattctg gcaagatgga ttagtgggtt

6421
ccagaaagta ggggcagcca caaataccga aataaatgag atcgtattat tgagaaagca

6481
caaatggaag aaggtcaaaa gcaagaagaa gctgacatcc tgcttcctcc aatttttgct

6541
ttctctgttt ttccaagaaa ctcctcttcc aagccttgct gaaaaactcc actttcctaa

6601
atctaacttc ttaaactgat aatggcaaga agttaggaat gaccaatatg tttaacactc

6661
caagagtatt tgttttgttt tgttttgaga ctgggtctca ctctgtcgtc cagcctggag

6721
tgcagtggtg tgatcacagc tcactgcagc cttgacctct cctgcccaag gaatcctccc

6781
acctcagcct cctgagtaga agggaccaca ggcatgtgcc actacacctg gctaactttt

6841
aaaaaatttt tttgtagaga tggggttgcc caggcaggtc tcaaactgct gggctcaagc

6901
aatcctcctg cattggcctc ccaaagtgct ggaattatgg gcataagcca ctacgcctga

6961
cctctccaag ggcattcttt acccagaaga ggaacttggc agaacttatc ctccaattgg

7021
tgaggaatat ggagaaaatg actttaagca aaggaacttc tggttctgcc tacctaatcc

7081
agaaaaagaa gttttatttc tcccttcccc tagtaactat cttcccatat tcacataaaa

7141
aagtacagaa tcaacattgt tcaagaatta taattttact tgtaagcaca tgtgcacacg

7201
cacacccata taccttcctt ccctttaaat catcccacac cctaatagta gtaaaatcat

7261
tgacccgagc atacctggga gaggaagagg agtctgacag gggcaggttc taagtggcac

7321
tcctggaact taaccctggt gtatatgaac tttacctatt gaaggatgac tcctcaactg

7381
ttctcacaat ttgctgctct gctttctttt ctaatttctg aaggtgactc atcttcccca

7441
aggactttca gacttctcag aagaaaaaaa tattgggtgg gtctctgcca ctggcaaaag

7501
attagacttt gagaatcata aaagtatatc agtatatact cattaatatt gaattactat

7561
aattaatatt atgatattga tataatgata gaatgatatt gataaaagca atattcaata

7621
atgaatatta tttcagctgc ccacttattg ggtgcctcat aggtgccagg cattttgtat

7681
gtattatcta caacccttac atgggacata ttatgatgct gtttctcttg aagaaatatg

7741
gaaactggaa acagagaggt caccacaatt ttccaaagtc acatagctaa taggtagcag

7801
acttgggatt caaattcata tgcatatggt aaatcatgct cttcctctgc tacattttgc

7861
ccccttagaa tatgaaaaag ggatacaaag agatgaagaa aatatgtaag attatccttc

7921
aatttcacta tcttttttaa agtttttttt attatacttt aaattctgaa atacatgtgc

7981
agaacatgca ggtttgttac ataggtatac acgtgccatg atggtttgtt gcacccatca

8041
acctgtcatc tacattaggt atttttccta atgctatccc tcccctagtc ccccacccac

8101
cgacaagccc cggtgtgtga tattcccctc cctgtgtcca tgtgttctca ttgttcaact

8161
cccacttatg agtgagaaca tgcggtgttt ggttttctgt tcctgcgtca gtttgctgag

8221
aatgatggtt tccagcttca ttcatgttcc tgcaaaaggc atgaactcat tttatggctg

8281
cataccattc tatggtatac atgtgccaca ttttcttaat ctagtctatc attgatgggc

8341
atttggctta gttccaagtc cttgctattg tgaacagtgc tgcaataaac atatgtgggc

8401
atatgtcttt atagtagaat gatttataat cctttgggta tagacccagt aatgggattg

8461
ctgggtcaaa tggcatttct ggttctaggt ccttcaggaa ttgccacact gtcttccaca

8521
atagctgaac tagtttacac tcccaccaac agtgtaaaag cgttcctatt tctccacatc

8581
ctctccaaca tctgttgctt cctgactttt taatgattgc cattctaatt ggagtgagat

8641
ggtatctcag tgtggttttg attagcattt ctttaatgac aagtgatgat gagctttttt

8701
tcatgtttgt tggccgtata aatgtcttct tttgagaagt gtccgttcat atcctttgcc

8761
cactttttaa cggggttttt tcttgtaaat ttgtttaact tccttgtaga ttctggatat

8821
tagtcctttg tcagatgggt agattgcaaa aattttcttc cattctgcag gttgcccgtt

8881
cactctgata atagtttctt ttgctgcgca gaagtttttt tagtttaatt agatcccatt

8941
tgtcaatttt ggcttttgtt gccattgctt ttggtgttta gtcatgaagt ctttgcccac

9001
gcctatgtcc tgaatggtaa tgcctaggtt ttcttctagg atttttatgg ttttaggtct

9061
tatgtttaaa tctttaatcc atcttgagtt aatttttgta taaggtataa ggaaggggtc

9121
cagtttagtt ttctgcatat ggctagccag ttttcccaac accatttatt aaatagggaa

9181
tcctttcccc gttgcttgtt tttgtcaggt ttgtcaaaga gcagatggtt gtagatgtgt

9241
ggcattattt ctgaggcctc tgttctgttt cattggtctc tgtatctgtt ttgatacaag

9301
taccatgctg ttttggttac tgtagacttg tagtataatt tgaagtcagg tagcgtaata

9361
cctccagttt tgttcttttt gcttaggatt gtcttgacta ttcaggctct tttttggttc

9421
catatgaaat ttaaagtagt tttttctaat tctgtgaaga aagtcaatgg tagcttgatg

9481
ggaaaagcat tgaatctata agttactttg ggcagtatgg ccattttcat gatattaatt

9541
cttcctatcc gtgagcatgg aatgtttttc catttgtttg tgtcctttct tatttccttg

9601
agcagtagtt tgtagttctc cttgaagagg tccatcacat cccttgtaag ttgtattcct

9661
aggtattttg ttctctttgt agcaattgtg aatggaagtt cactcataag tttgctctct

9721
gtttgtctgt tattggtgta taggaatgct tgtgattttt gcacattgat tttgtatcct

9781
gagactttgc cgaagttgct tatcagctta aggagatttt gggctgagac gacagggttt

9841
tctaaatata caatcatctc atctgcaaac agagacaatt tgacttcctc tcttcctatt

9901
tgaatacgct ttatttcttt ctcttgcctg tttgccctgg ccagaacttc caatactgtg

9961
ttgaatagga gtgttcacca cctattttaa gaatagtatt gaagcctcac aaaagctggt

10021
tctcatgtaa ccatctgaga atatttggcc ttatgacttg aattcattca ttgccttttt

10081
atttcacatt ttagtgatcc tgatgtctaa atcttaatct ttgatccttg caaggtaaaa

10141
tagccaagtc aagcctgttt aataatattg gttgaggaag tcacatgctt atgatcaatc

10201
tttgggttat gtaattatat taccttaatg ttggcagttt aggtgtaagg cagagatatc

10261
tgatcacatg tgtggttagc taatttaaga tcactgccaa ctaaaatctt catggtatga

10321
tcttcaaagt tagctacttt gaccacagca atgatttcac cacagcaatt aacaaaatgg

10381
cagactcttt cctgaggtgg catgaacagt tttaaaacaa agtcaaggac caaaagaaaa

10441
gcaggcacat ggcatttgat tcatttcaaa aactagtatt gtattaagag ccaaggggat

10501
agaattgtag catcaattaa aatcttgttt gaaaaaaaat aaaaacaaac gtccattttt

10561
atctctcaaa tatattaggg ttttcataaa gttataggtg tatttttaaa aaaacaaaac

10621
tcatatacat tagactgaaa aatttgcctg tcatctcatc atgcagctaa atgcaattgt

10681
ctatggcgag atacactctt attagaggta tgatagcact aactaatagc aaactttgta

10741
cctggtagtc taatttatgc agggttcata tttcgctccc tctcagcatg ctgtaactgt

10801
ggcaaagcca ttctcaggag ttattacccc aacataatca tacccctgtg gattaggagc

10861
agttaaatgg gtcctgttat cagagacaca tatgtgccac agccgcbgtc atccctaagc

10921
caccgtgggt gattaagact cactgatggg actacctctg aataggcttg agtgaggtgg

10981
atacacttca gctgagagaa attcaggtaa ggggctgaga aaatcagatt ttgaatggtt

11041
ttatcatacc atcaggtctc cttttaagtg ctggggtcat ggatttcatt caacctgacc

11101
acatagcctt tggaagcttg gctcaatacc tgagtgtgag attatgggtg atattaaagg

11161
agatgaatgc attgagctga tgtcagagaa tgtcttttac tggattttca taatgactgg

11221
ctgcagatgg gctgagggga aagtcagatc aagagcattt ctgtaagaag aaagaaatct

11281
tccctcttat tctctttcaa gaaaatgaat agctgagcac caagaggcca aatacttttt

11341
taaaaaacac atccttttat gtagagaagg acaggttgag acgaaaaaca ggacctctga

11401
aactgtcttt atagctttaa tctaggaaga aattgcggca ccattgctga catcattatc

11461
agaggctgcc ttagttctga gagcttcaca gatggccttt tctgcatttt acatctggcc

11521
agatgaaggc aaaaaggttg atgaaaccaa aactattaga tcagtggtcc ataactctgg

11581
ctgcacttta gaatcatctg gggagtcctt aaaactactg atcctgaggc tccatcccag

11641
accaattgaa tcaggatctc tgggggtggg acctgagcat tggaatgctt taaaagttcc

11701
tcagggactc taatgtgcag ccaaggctga gaatgactga ggtggatggt ggccaagaca

11761
ggtgaggcca agagttagaa gcccttactg ttagggaagg cagaagccac aaggaggagg

11821
ggagggggaa ggagcagtat ttagcatttc ttccacacag ttggggggtt ttctgatcaa

11881
aattaggctg ggatctttcg cttccatttt catgaaggtc ttatgctttg tccacagcca

11941
cctggcctca gggcaatgag caatctgatt gatgaatttt cagtaagaaa ctgagcacac

12001
ttggctctca gccccagtgg cttcccctgt ttccaaatct gcccaccagt tacaggagcc

12061
tgctcaccaa ctggttgggt taaagaagtc ggctctgtcc ttggcaggga ggccttcagc

12121
tgtctggccc tgtctgtgac tgcgtgggtg aagctgccta atttggggaa cttgatggaa

12181
gatctaagct atgttctcta acagttttat cagaaataaa gttaactttt gacctccatc

12241
tgcctgtctc ctgtggaagg gctctgctcc ttccaaagag actctcaggg gttctcctta

12301
gaggtgtgtt atcagtccaa agatcatttt agaccagcca ttacagagga tgtccaagaa

12361
attgcacaag ggaaatagaa gtaagaatga gagcaatata tcagatagta aggaaagtat

12421
gtgactggtt tcaaataagt aattaaccat aaatccaaag ttcctgcatt agttatagca

12481
atagtcatcc acctggtcag gaaaaaaaaa gtaaaagact gagctgcaag atagaaagtt

12541
tgcctgaatt ccacgtactt caaggactac tatggaggat tccttggtcc caatgcagag

12601
acatgtactc tgaccaccca tgggccaaat ccctcttacc caccctcagt gattcctcct

12661
gggacctcac tacattgagt tcttacattc cccactcttt tcgggggaaa tataaccctt

12721
ctgctcttct catgatgtta aaaatattta gacaattact taaaatttac aacaatcttc

12781
cacataaatg atctcactta tgtttcttgt gagctctgtg atttatttct attatcatct

12841
atgctgatag ttaaggaaac tgagatatcg agaccaacat gcatagtaaa tggcaaaacc

12901
agatgaattt taaactttcc taactccaaa agccacatcc tgcccaaccc gccatgctgc

12961
cgctcagtta atgcctggct gtttgtctcc ccattggccc ctctacccat tgtgctttga

13021
tggcacactg tattccaact gcctgagact cctggttaat gccattacgt acagacttag

13081
gttgaattta ctaggatttt taagatttgt aggataagag atatgactgt tagactggaa

13141
tcagcaatag ataaaaggtt aacaaagttt cagaataaaa tataatagaa aaccccagca

13201
gatagaagta aaatgaatgg taagacaact gaaatgaaag ccatacattt agaaatatca

13261
aataaaacac agattaatgg cagacaataa aggaacatac ttagcagtta gtaaaaacac

13321
tttttacctt attcttatta ccctccagta accttttttt tttttttttt tgagacaaag

13381
tctcgcbgtg tcitccaggc tggagggtag tgatgtgatc tcggctcact gcaacttctg

13441
cctcttgggc tgaagagatt ctcctgcccc agcctcctga gtagcbggga ctataggggc

13501
ccatcactgc acctggctaa tttttgtatt tttagtagag acggggtttc accatgttgg

13561
ccaggctggt cttgaactcc tggcctcagg tgatccaccc gcctcagcct cccaaagtgc

13621
tgagattaca agcgtgagcc accaagcccg gctgtaacct attgaaaata acattacttg

13681
acatgtgaga caaattattt gtaagttaaa gagtttatgt gccttcaatg ctcccaccct

13741
tccctcccct aaaaagatta ttgagtgccc atgatgtgcc taagccttct ggtagactct

13801
gagaatgtga agagagttag aggatacttg ttcaacaacc cagaatctag cagaagtgtt

13861
ttgaaatgac cagccacttg ggagagctat gctagcatat cattcaggat gggctgggtc

13921
atgttttaat aacaagtaag tttgaacttt ataggtttga aacaaaaaag atgtgtttct

13981
tgctcacagt tcatattttt tggagattgg ctggagcttc attccaggat actgccacca

14041
tctggaatgt tgacagttac cgtaacagag aaagagttgt ggaggcbgtc acactggcaa

14101
ttaaattcgc tgacctggaa ctgacacatg ccacctccac ttatatttta ttggccaagg

14161
cttgttacac agccacatct aacttcagag aggtcaagat gagcaaatcc taccacgagc

14221
tatagatgga tgagtagcac tcattattat cacaattatt ttatttgtta taaaaactcc

14281
aagaaggaga ggtactctat gtgaggaata ggcataggaa aatcagaggg aagttcttaa

14341
agatgagcta gatttcacta gatggcattg aagaaacatt ccaagtaaat gaacagcata

14401
agcaaatgca tgaagaactt attgtggtcc tagtacagac gatgcgtgag agtgtggagg

14461
agggaaaagg taagactgga gaggaaggca ggaaccagaa caggacagac tgtgttcact

14521
gtcaggcagt taagtctatc ttgtaggcaa catgaagcct tttaaggaag gcaagcagct

14581
atgtgacagg acagaagatg gattggaaga aaatcaaaag agaagtgggg accagtcata

14641
aggctcctcc aatatttggg gatccaaacc aaagcactgg cagagaaata gaaaggaagg

14701
gaaatatttc caaaatattc aaaacagaaa ccaagagaac ttgatgacag aagatgaacc

14761
caggtttcta ctgaatggac agttgttaca ttctctgaga taaggaatac agaaggaaaa

14821
agttgagagg gaatatgaaa ttatttttaa tcatgtttaa tttgatcact tgtggaacat

14881
caaccagaga tgtccatcag ttacaccaat ttgtaggttt tgagagaggc ctgaggtaga

14941
ggcagagaag tgggaatcag cagattagcg gcagtagttg gaaccataac tgaagatgag

15001
atttcccagg gaggggagtt gaacaggaag gtagacaaag gctgagtgca gtggctcata

15061
cctgtaatcc cagcactttg ggaggctgca gtgggtagat cacaaacaag atcaggagtt

15121
caagaccagc ctggccaaca tggtgaaacc ccgtctctac taaaaaaaca caaaaattag

15181
ccgggcgtgg tggcacacac ttgtaatccc agcctcagga ggctgaggca ggagaattgc

15241
ttgaacccgg gaggcagagg ttgcagtgag ccaagatcgt gccattgcac tccagcctgg

15301
gcgacagagc gagactccgt ccccaccgac cccctaaaaa agaaagtaga caaagatgtg

15361
tcctagaaaa cactaatatg aatgggtaga gaggggagac ttgtcaagga gatcgagggg

15421
agagtcagtg aggtgaaacc ttagaggata gaccttcacc aaggaagtaa cagtcaacag

15481
gcctaaatgc cacagagatg tcaaatgaga gacactggaa atggttcttt gaatattaca

15541
gccagaacat cacaggagac catttccaaa gcagtcttga tgaagtggtg gggaagggag

15601
gtccctgaag gagctaagga gggactggga gatcatgacc cagagataag tgttgcaggt

15661
ataaaaggga aagactgaga tcaggaaata gccacaggat ccctaaggcc aggcttcggg

15721
tggggtggtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tataaaatgg gaagaccttg

15781
agtataattc tgtactaaga agatagagca gtagagagga aaaggctgaa gacagatggg

15841
agggtaaata gtgaattaga aaggtctgtg caaagatgag aaaggatgag tctgaaagca

15901
cagggagaag ggccagcctt ggacaggaga aaacatttct ttcactaaga ataaagggaa

15961
ggttgggtat acaccacaaa gaaggtgtag atgggtggca atggagttct gtcaagttga

16021
gggcattcca tgatagcctc acctttctct gtgaaatgag agagtttagt ttacaagata

16081
tttctgagca cttcataagc caggttcata gactgaaaga agtggaggtg gagtgtgata

16141
ggtccttaag aataggggaa gtttggaata tctgacaagg gacagagagg aaaaaactag

16201
aaaaggcttt gcagaatgtg ggcccacaga tcagaggcta aggggtcccc atttgtgcag

16261
gagagtaagg gcagggaggc aaggctcaca gcccaaaata tagagcccct caccaaatga

16321
ctgcaggagg gcagctttcc tatgagagca tccctatcac tgttttcact ccgagtcatt

16381
aacttacgac ttactcagct ctgtttcgta atagcagact cgagtaatga gggtatgaca

16441
gcctctctct gcatgccaag gtatgcagcg tggatttcct ttttcgcttt ctctctcctg

16501
tggcttaggt gccttctgtt ctgctaccag gatagagaac ccagtgacta gtttcttcta

16561
gctctctttt tctgactagg tatcttgtca gaaatttctg cttaccagac ttcatggaga

16621
gggaatcaag ctttgaatca gggttgaaaa agtagagctt aatatatata ttacaaaatg

16681
ccactcacgt tcttgaggtt accttgtatc tataccacaa ctagcattct tttagaaagc

16741
accattaccg aagtaatccc tttcctggga attcacccaa aaaggttatt cccacttatc

16801
ccccatctcc aaaataaaaa agaaaaatgt gtgtgcttag agatgttcct ggaagcatga

16861
gctgtaatac tgaaccaata gaagacgaac taacagattg cagggcatcc gtttggcaaa

16921
aaacttatgc agttatctaa atgatagtta tgaagacaat atgtataaca cattatattc

16981
tgagtgaaaa gaacagaagg tgatttcaaa actgcattgg gataatagta atataggaaa

17041
tagtgagatg aacaaagatt tcaaaggaac aaaaataaag aaaaattttg ctttttatat

17101
tggtaggcgt atgggtgaaa ttccaatttt aattttaatt tcatagttat aaaattgttc

17161
ataaaaaaag gtcccccata gacagttggg ctttgggaca aactaacaga aacagagtag

17221
gaagaaaatt catcttcctt caatcccctt tctctgctta aaacaaaaca aaaaagagct

17281
ttgtcatgtt caggtgtgca acgaattctt tttccaaatc tggaacttta catctgctat

17341
taaacaggag tcagtttcca tgtaacatgt tgacaatccc ccaagtgtgt tggaataatt

17401
ttttttaatg aggagatttg aaattccatt tcaattgcca acctgcctct ttcaacttct

17461
aaaaacaaag taaaacaaaa caaaaacaca ctgggtccta tcaccccctc ttgctactac

17521
tattttatct ccattgccct gaattctttc caaacttctt tccacccagc tttgatttgt

17581
tttcagtcgg gtttattgag gcataattta cgtacagtaa aattcatcct tcttagattt

17641
agaggtctat gcattttgac taatgcatat tggcttataa tgactaccac aacaaagata

17701
tagaacacac ccatcactcc cgggttctcc ctgtcccttt tttggtccat ctcctctcct

17761
acccccaacc ccttggcaac cactgatctg ttttctgtcc ttatcatttt gctttttcca

17821
ggatgttgta tataaggaat catgcagcat gcagcctctc gagtctgact tcttccagtt

17881
agcacagtta tttaagatct atccgagtta ttgtgagtag cagcatcttt tttattgctg

17941
actagtattt catcacatgg atgggccaca acttgtttat ctgttcacct gtcaatggat

18001
actaagttgt ttccagtttt tggcaaatat gaataaagta aacatttgca tacagatttt

18061
tgtgtggaca catgttttca attctcttag gtaaatactg agcaatggga ttgctgggtt

18121
atatgttaag tctatgttca gttttctaag ttctgaaaca attggatatc tatatgcaaa

18181
aatacaaaat taaccttgac tcaaacttgt accatacaca aaaaataacc tgaaagagat

18241
cacaggtgta aatgtaaacc tagaactaaa aacttcaagg agagaaacat agcagaaaat

18301
atttgtgacc ttgcattagg caaagacttc ttagatttga catttgaaac atgatacata

18361
aaaaatcttg ataaattgga gttcataaaa ataagaacta ctcttcaaaa gacactgata

18421
agagaatgaa aatacaagcc acagacagag aaaatatttg tgaatttctt atctgataaa

18481
gggtttgtat ccagcatgca taaagacttt tcaaaactca ataataaaca atccaataag

18541
aaatgcacaa aagatacaaa cacatcatcg aaaatgacct atgaaaggca aataagccca

18601
caaaaaaatt ctcaacatca ttagacactt gggaaatgca aattaaaaca acactgagat

18661
aaactacata tctattaaat ggctaccact ttaaaaacct gtcaagtgcc agccagaatg

18721
tggaacaagt aggactctct tacattgcta gtgggaaggt gaatggtaca gccactttgg

18781
aaaacactcc gcagcttctt atagttacac ataggacctg ggggtagagg atggattgac

18841
tgtaaagggg caaaacttcc tggtaggggt ggggaaagtt tttagaaggg tgaaattgtt

18901
ctatatcttg attattgtgg tggttacaca actgtctgca tttgtcaaaa ctcacagaac

18961
tgtacactaa aaaggtatat ttttatgctc tgctaatttt actttaatct taaaaatagg

19021
aaggaaaaaa taaaatcaat gccactgtgc gactttgggc aagttacttc acttctctgt

19081
gccttggtct tttgaaatct atacattaag gataaaataa taccttcctc atactgttag

19141
aattaaatgt gctaatttat gttttatata tataaagtac ttggccgggt gtggtgactc

19201
acacctgtaa tcccagcact gtgggaggcc gaggtgggca gatcacttga ggacaggagt

19261
tcaagactag cctggtcaac atggtgaaac cctgtctcta ctaaaaatac aaaaattagc

19321
tgggcttggt ggtgcgtgct tgtaatccca gctacttgag tggctgaggt gggaggatca

19381
cttgaactcc agaggtggag gctgcagtgg gctccaccca ctgcctgggt gacagagcta

19441
gactccatct cgaagaaaaa ataagtactt gaaacatagc aaatgtttta taattattgg

19501
cttttttttc ttattgttat tacttgcatt attgcbgttt gaagaagttt ggtgataatg

19561
gagagaaaag ggcaattagg ggtctgggat ggtttaagta tgaggagacc gagacacatt

19621
gactcagagt gaagaaatca aagataagag aatgaaagaa agggagggta attctgaacg

19681
cacagacaaa gttatgttac taacgtggca tcggcbgtgt gttgtaataa ataactccct

19741
ttcacttgtc aatagctaat caaatacttt ctggagacca gaagtgactt gctggatcaa

19801
tgacaactcc tccacagatc aaaatgttca aatccttttt ctgtgttgta atcctaaatc

19861
taaaagaaca gagagaccaa gcaaatctac ctcccaacat cattaaagtg acaactctca

19921
gtatttattt gaatggtctg ctctcagctt caaccaagga aaagtcaaat tagtgttggt

19981
cagaaaacag aagggtgtta cgagagttct ggctggtcat tacagacttg gggatttttg

20041
attaaaagaa gaagaagaag aagaaacctg ataaagtgta aatatagcaa gcagggatta

20101
gtgtcctgct gggtcatgtt ctcacaacag tgagaatttc agagatttca taagaattaa

20161
actgctccac atgacaattt attttacctt ctggcttttc caggaggcaa atcagtgcaa

20221
cttctttctg cctttgtttc aatttggtaa caaccctcaa ttttaggaca ggctaaacct

20281
agccacccta tcagagatga tgaagtagcc atctttttaa caggtgggga gatgaatgga

20341
atcagggttt gtttgtttgt ttgtttaata actgctagta aaaaccaagt caatagctga

20401
ctgagtgtaa gggaggctcc agaaggcagg ttattgtagt atagatgtga ctcgacttat

20461
gatgatgtta cttcccgata aacccgtcat aagttgaaat atcgttaaat tgaaaatgct

20521
tttaatacac cgaatctacc gaacatcata gcttagctca gcctacgtta aatgtgctca

20581
ggacgcacat tgcctacagc tgagccaaat cacctggcaa cacaggacac tgtagagtat

20641
cggttgctgg cccttgtgat gctgtgactg actgggagct gcgcttagtg cctctaccca

20701
gcattgagag tttcttatcg cttattacta gcctgggaaa agaccaaaat tcaaaactca

20761
aagtgcggtt tctaccgaat gcttataact ttcagaccat catgatgttg aaaaatcgaa

20821
ccatcgtagg ttgggatcca tcctataaga cgagctacac tgccggaagt gtaagactgc

20881
tatgctgccg gaagatgggg catagtggac aactgcaagt cctgacaaca ggaggtcagc

20941
atctgcgacc tttaacatcc acattgacac taccacagtc ttccaaacag agctgatgat

21001
atagtttgga tgtcgtccct gcccaaatct catgtcgaat cgtaatcccc agtgttggag

21061
gtggggcctg gtgggaggtg attgggtcat gggggcagag ttcttatgaa tggtttagca

21121
cggtcccccc ttggtactgt atagtgagtg agttctcatg cgatctggtt gtttaaaagt

21181
gtgtggcacc tcccctctct ctctttctcc tactctggcc atgtgaagtg ttggctcccg

21241
ctttgccttc caccatgatt gttaaattcc cagaggtctc cctagaagct aatgctgcca

21301
cgtacagcct ggagaactgt gagccaatta aacctcatct ctttttaaat tacccagtct

21361
caggccgggc gcggtgactg acacctgtaa tctcagcact ttgggaggct caggcaggaa

21421
gatgatttga ggtcaggagt tcgagaccag cctggccaac atggtgaaac cccatctcta

21481
ctgaaaatat aaaaattagc caggcatggt ggcgggtgcc tgtaatccca gctacttggg

21541
aggctgaggc aggagaatcg cttgaacctg ggagtcagag gttgcagaga gccaaaatgg

21601
agccactgta ctccagcctg ggcaatggag tgagaccctg tctcaaaaaa tatatatata

21661
ttacccagac tcaggtattt ctttacctga gactatgaga gaatggacta atatagctga

21721
agaattttat tttattttta aaaaactttt acgtttgggg gtacctgtaa aagtctgtta

21781
cataggtaaa ctcctgtcat gaggatttgt tgtacagatt ctttcctgct cctccccctc

21841
ctcccaccct ccatcctcaa gaagatccca gtgtctgttg tttccttctt tgtgttcgta

21901
agttctcatc atgtagctcc cacgtataag tgagaacatg cagtatttgg ttttctgtcc

21961
ctgtgttagt ttgctaagga tgatagcctc caactccatc tatcttcctg caaaagacat

22021
gatctcattc atttttattg ctgcatagta ttccatggtg tatatgtacc acattttctt

22081
tatccagtct gtcattgatg ggcatttagg ttgattctgt gtcttcagaa ttgtgaatag

22141
tgctgcaacg aacattcgtg tgcttgtgtc tttatagtag aatgatttct attcttctgg

22201
tagtaatggg attgcbgggt caaatggtcg ttctgctttt agctctttgc agaatcacca

22261
tactgctttc cacagtggtt gaactaattt acactcccac taacagtgta taagtgttcc

22321
cttttctctg caaccttgcc agcctctgtt atcttttgac tttttaataa aaaccattct

22381
aattagtgtg atggtatttc attgttgttt tgatttgcat ttctctaatg atcagtgatg

22441
ttgagctttt tttcatgttc gttggctgca ggtacatctt cttttgaaaa gtgtctgctc

22501
atgtcctttg cccacttttt aatggggttg tttttctctt gtaaatttaa gttcctcata

22561
gatgcbgggt attagacctt tgtcagatgt atagcttgca aatattttct cccattctgt

22621
aggttgtctg cttactcttt tgattgtttc ttttaccatg cagaagctcc taagtttaat

22681
tagatcccat ttgtcaattt ttgcttttgt tgcaattgct tttggtgtct ttgtcatgaa

22741
atctttgcca ggtcctatgt ccagaatgat attgcctagg ttgtcttcta gggtttttat

22801
agttttgggt tttacattta aatctttaat ccatcttgag ttgatttttg tgtttggtgt

22861
aaggaagggg tccagtttca atattctgca tatggctagc cagttatccc agcattattt

22921
attgagtaag gagtatctcc tccgttgctt gtttttccca ggtttgttga agatcagatg

22981
gttgtaggtg tgtggcctta ttttggggct ctctatcctg ttcatttggt ctatgtgcct

23041
gtttttgtac cagtaccatt ctgttttggt tactgtagcc ctatagcata tttcaaagtt

23101
gggtaacatg atgcctccag ctttattctt tttgcttaga attaccttgg ccatttgggc

23161
tctttttggt accatatgaa gtttaaaata gttttttttc tagttatgtg aagaatgtcg

23221
ttggtaattt gataggaata acatgtaatg atattgattc ttcctatcca tgagcatggg

23281
atgtttttcc atttgtttgt gtcttctctg atttcttcaa gcagtgtttt gtaactcata

23341
ttgtagagat tattcacctc cttgcttagc tgtattccta ggtattgtat tctttctgta

23401
gtaattgtga atgggattgc ttttctgatt tggccctcag cttggtattg ttggtgtata

23461
ggaatgctag tgattttttg tatcctgaga ctttgctgaa gttatttatc agctgaagga

23521
gcttttgggc tgagactagg gggtttttta gatatagaat catgttctct gcaaacagat

23581
ttagtttgac ttcctctctt cctacttgga tgccctttat ttctttctct tgcctgattt

23641
ccctggccag gacttccagt accatgttga ataggcgtgg tgagagaggg cattcttgtc

23701
ttgtgccagt tttcagggag aatgcttcca ccttttgccc attcagtacg atgtttgtgg

23761
tggtttgtca tatatggcta ttattatttt gaggtgtgtt cctttaatac ctagtttatt

23821
gacagttttt aacatgaagc agtgtttaat tttattaaaa gtcttttctg cctctgttga

23881
gatagtcatg tggcttttgt ctttagttct gtttatgtga tgaatcacat ttgttgattt

23941
ccttatgttg gaccaacctt gcatcccagg gatgaagcct acttgattgt ggtggtttag

24001
ctttttgata tactactgga ttcagtttgc aagtattttg ttgaggattt ttgcattgat

24061
gttcatcacg gatatcggcc tgaagtttct ttttttgttg tgtctctgtc aggttttggt

24121
atcagaatga tgctggcctc ctagaatgag ttggggagga gttcctcctc ctcaattttt

24181
ttggaatagg ttctgtagga atggtaccag ctcttcttta tacatctggt agagtttggc

24241
tgtgaagcca tcaggtcctg ggatttttta gttggtaggg tatttattac tgattcccta

24301
aatagaccga taatgatttt agaagtggag tcggtttttt cctggtccag tcttgggaag

24361
gtgtatgtat ccaggaattt atttagctct tctaggtttt ctagtttgtg tgcatatggg

24421
tgttcatagt agtttctgat ggttgttttt atttccgtgg gatcagtggt aacattctct

24481
tcatcatttc tttttttttt tttttttttt ttttttgaga cggagtctcg ctctgtcgcc

24541
caggctggag tgcagtggcg cgatctcggc tcactgcaag ctccgcctcc cgggttcacg

24601
ccattctcct gcctcagcct cccgagtagc tgggactaca ggcgcccgct accacgtccg

24661
gctaattttt tgtattttta gtagagacgg ggtttcaccg tgttagccag gatggtctcg

24721
atctcctgac ctcgtgatcc gcccgcctcg gcctcccaaa gtgctgggat tacaggcgtg

24781
agccaccgcg cccggcccat ttctaattgt gtttatttga atcctctctc ttctcttctt

24841
tattaggcta gctagtggcc tatctatctt attaattttt tcaaaaaacc agctcctgga

24901
tttcttgatc ttttgaatgg tttttcatgt atcaatcctt cagttcagct ctgattttgg

24961
ttatttcttg tcttgtgcta gctttggggt tgacttgttc ttgcttctct aattctttca

25021
gttctgatgt tagtttgtta gtttgagatc taactttttg atgtggacat ttagtgctat

25081
aaatttaact cttaacactg ccttagctgt gtcccagaga gtctggtatg ttgtatcttt

25141
gttctcatta gtttgaaaaa acttcttgat ttctgtctta atttaattat ttatccaaag

25201
tcattcagga acatgttgtt taatttccat gtaattgcat ggttttgagc gattttctta

25261
gtcttgactt ctatttttat tgtaccgtgg tctgagggtg tttgatatga ctttggttct

25321
tttgcatttg ctgaggattg ttttatgtcc aattatgtgg ttgattttag agtatgtgcc

25381
atgtggtgat gagaagaatg tatattctgt tggttttggg tacagagttc tgtagaggtc

25441
tattagatcc atttggtcca atgttgagtt cagatcctga atatctttgc taatttcctg

25501
cctccatgat ctaatactgt cagtaaagca ctgaagtctc ctactactat tgtgtgggag

25561
tctatgtctc tttataggtc tctaagaact tgctttatga atctgggtgc ttctgtgttg

25621
gatgcatata tatttaggat agttagatct tcttgttgaa ttgaaccctt taccattatg

25681
taacgccctt ctttgtcttt ttttttcttt gttggtttga agtcttcttt gtctgaaatt

25741
aggattgcaa cccctgcttt tttctgtttt ctgtttgctt ggtagatttt cctccatccc

25801
tttattttgg acctatgggt gtccttacat attttatctt tatctatcca tccagccatc

25861
cagccatcca ttcatccgta tcatttttaa ccaataagga cttttaaaag cgcaaccaca

25921
acaccattaa cataaccaat aaaatctata acaatgataa aatatcatct aatactcagt

25981
ccatgtccaa ttttccctcg ctatctcaaa atcgtcttct tagaaatggt ctgttcaaat

26041
gagatcacat ggacagagga aggcgaacct cacactgtgg ggactgttgt ggggtggggg

26101
gaggggggag ggatagcatt gggagatata cctaatgcta gatgacaagt tagtgggtgc

26161
agcgcaccag catggcacat gtatatgtat gtaactaacc tgcacaatgt gcacatgtac

26221
cctaaaactt aaagtataat aataaaaaat aaaaataaaa aaataaaaag tgaaaaaaga

26281
aaaaaaaaaa aaaaagaaat ggtctgttca aatcacaaac cagattcaga aacaatagcc

26341
atacattaca ttttattaat atgtctctta aatttctttt aatctattac agtctttgga

26401
atttttatgt cttcgtttat ccttccaatt attaaaaaaa aagtattttt gtattcattg

26461
aatagacaat gcttgcagaa aagtaaaaaa aaaaaaattt agtacaaaaa ggtacatagt

26521
gagcbgttcc ttagtctccc ttcccagaag caatgttacc acttttgtac aaatagtctc

26581
tgcctagaca cacatgccag tccctaaggt ggctgtaaca aggtggttaa gagtgagaac

26641
atgaattcaa attcctatta tgccactcac taagtataaa tcttggtcat ggtacatgcc

26701
tctgtgcctc agtttttaat aatggtacct acctcatagg gctgttgaga gaattaaatc

26761
agataagtgc ttaaataact attaatattt attattattc acattccctt ttggcttttt

26821
tcccaaatag cagagtggtg cacatatgtc ttcatttatt tggcttgttt tttcacctca

26881
catcacattt tgatgaataa ttccatacat gttgttatag atttgcttca ttctttgtaa

26941
tcattgacta atattccatt gtatgaatat gctactgcta aacatgtacg ttatttccaa

27001
cctcttatta tcaagaaatg ctgcaatgaa tatccttgta atactttagt ggattcatgt

27061
gcaaaaatat tcataggata aaatcctgaa agttaaattg ctgagctaaa gggtatgtgc

27121
attttaatgc tttatagatt gcccagctgc ctcaaaggag gttataacaa tttacactcc

27181
caagaaaaat gcacaagggt ccccatttcc ccatacccta gctaacacag gatattgcta

27241
aatgctttca tctttgtaaa catgatgtat tgaaaatggt atctcaaagt tttaatgtgc

27301
atttttctga ttgtgagaag ataaaggaaa tgtagtacaa ctaaacatca gcagtcaaat

27361
gacctggcca tgactcctga gtgaggacac tggtaaacac catcaggatc caaacacctc

27421
tgtatttacg aagaggatgc tccctattgg atagcactaa gcttatttca tgtatgtaca

27481
tatgtagtta gttaattaca tccagcggtg gcaaagggct tgttctgacc caatgaaact

27541
ttctctcctg gcccccttcc agcatgtggt caggagtaga gtgttgtggc catgaggcat

27601
gcatttgtac agatgactac ttactcctcc ttgaaacatt tttttccatt tgcttccctg

27661
ctgtctcact catgggtctg ctcctaattc acaaatcact cttttcccag tcttcttggt

27721
tgggttttct cctcttctgt gcttgtagac atgggggagc cccagggctt ctctcttgaa

27781
ctacagcttc tccctgggtt catctccttg ggatgtctgt tccaatgggt ttaaatacta

27841
gggctaggac tagggagagg tcattgaggc acttagcaca taaagtttaa ggaaacattc

27901
tttatcaggc ccatgcaagt gcaggactgg ccctggaggg tgactaccac cttacctttt

27961
ccaccctagg caccttgttt gccttaccct agccccagtc ctctttaaca ccccagtctt

28021
ctccctggac ctccagaaac ataaatccta tttgacattt ctacttggag gttttaaggt

28081
aactcaaacg taaaatatct aagacagaac tcttgcatca cttcccatcc tggggcccaa

28141
gcctgtctct tctactagtc tatctcagtt aacagcatca ccatttattc agttgctcag

28201
gacaaaaaat ttgaagtaat ccttgactct tctttttttt tttttgagac ggattctcac

28261
tctgttgccc aggctggagt gcagtggtgg gaccttggct cactgcaacc tctgcctcct

28321
gggttcaagc aattctcctg cctcagtctt ctgacctcgt gatccactcg cctcggcctc

28381
ccaaagtgct gggattacag gcgtgagcca ccgcacccgg cctggattct tttttttttt

28441
tttaaacaag tcctatcttc catctccaaa atgtatccca aatctgacaa cctctcccac

28501
cgtaggccag cccccatctc tcccctctga aaatagcctc ccttagatct ctggacattt

28561
gttcttcccc acccccttgt gatcactatt cagcattcag aatgatcttt taatattatg

28621
aaggagactg tgttcctctc ctacttaaaa ttctctagtg gcttcctaat aaatttagaa

28681
taaaaagcca actcctcgcc atggtcacca ggccaggatc cagtgggtac aacaatctgt

28741
tcccagcaca ataatcccac ttctgcctcc ccaccattca ccaggctcca ctgcactggc

28801
tcattcctgc ctcagttgtg cttcttttcc ctggaaagtt ctttctgtag atctttaaag

28861
ggtgatttcc ttctcaacat tcaggtgtca gctcgtttca ctttcctgac catgcccatc

28921
cactcagaga tcactcaaaa tcccattacc ctattttatt tctccatcat atgtatcact

28981
atctgaaact atcttgttgt tgatgcaggc tattttcttg accccttcat gggactccca

29041
acaggggtac cccatttact cagcctgccc tgctcaacct cttgcaggag ggagcacacg

29101
agtgaacgag tgcaggaacc agctggctgc tttagtgctg tgaggagtaa actccatgca

29161
ggccctgcag cagcaaccag gtaggggtgc ctgcaacccc agggccccag agggtgtgtt

29221
acaatgctct cgtagctctg ccatctgtgg acagcagtgt gttgtcagct cagtgggccc

29281
tttgcttcat catgtagggt ggctgccctc tgcctgtgag ggcaaagggc cagggtgaca

29341
gtctttttgg gtacccacaa tttgtgcatc ctgaattctt gtttggtgcc caagaagaat

29401
ggggtcacac agatgaactg aaggatggtg aatgcagaga attagcaatg aaagtggctc

29461
tcagcagaga gagaagctga aaagggaatg ggaagggcag gtcactctcc cctgaagtca

29521
agtcacatct ctccaatgtc cagccaccat ctctgaagtc aagtttcctc tctctgatgt

29581
ccagccactt ctcctctcta ctggctgagt ctggggtatt tataggcaga ggataggtgg

29641
tggggcaggc catacataat tttggaaaag gcaacattct attggtaaaa agacattatt

29701
cataaagaac caattgggaa agagcgggca cacagggatg gaagttctca ctttgggctg

29761
caggtttcag gcttttcagc tcaaaagtga ggtttttcca gggacctgcc ccgtctgcct

29821
aaaatttcta cacttctgtc attgataccg ctggataaca gctctcctat aaagttcagg

29881
ggcttaaaac aaaaatttac taattcaccc ggacagttct tgatagggtc tctcctaact

29941
gttgcagtta catagcaact gggttggagt catcttttct gggcttgaca tccaggacag

30001
cttcttccct tgtgtgtctg gtgcctcagt gctcctccag gcagcctttc tctccagaag

30061
agtagcctgg acttcttggc aactcaagct tccaaaagaa aaaaaagcag agactgctgg

30121
ttctcttatc aaacaggcct ggaactggca caatgtactt ctgctgccat attcaggagg

30181
tcaaagcaat cgaaggccaa tccaagttca aaggcattgg agaaaaatga gaagtgtcac

30241
ttaaatgaga agtgacacat gcgtaaaagg gggaaaagca ttgattgtgg ccatttttgg

30301
agataagcta tcacgtttat ttgtttgttt gctttctaat ggtctgtctt ctcccattag

30361
gttataagct ctgtgagaca acaggaatct tgtccatctt gttttatggc tctacttcca

30421
acacctagaa taatgcctgg cacatagtag gtgctcagtg aataacttaa gcacttgata

30481
catgtttggg gaactaaaat gaacagaatt aaacttcccc agattggtcc tgccagattt

30541
gctgatgcca agcatgctga tgcctcacca gatgaaagaa gccctaaaat gtagggtttc

30601
gctttctctg caaacaagaa aaacttgccc tgaacacaaa atctagaaat agatttggcg

30661
tgttttctac attgaaatat ttcccgtagt accagaaatt attttcccac agctttgtgc

30721
tacattaaaa tattgaagtt gactgaaaat atctccattc tttaatcttg gtgtagacta

30781
gaaacaattt ttttgtaaca aagtaaatat gaaaacttcc taatatttga actccccaga

30841
tatccccaga tatctccaaa cttaaaatat cattgcaagt taagataaat ttttttaaat

30901
gactaccgag aaaggtcatt aaaggcttgg ttattaaaat gtacagattt gggttataaa

30961
gccagaactt atttgtttaa atcattacat atgaccaagc acagaaaata aattacctca

31021
aatctcctct ttgctaattt ttactggtaa actctataaa atgatcctat ctttaaacct

31081
ttttgtaaac cccttataag ttagtaagtg agaatgtatt catcagaagg attttagtga

31141
tgtttgaaat taaaaaagag agatttgatt tttaaaatta tacttgcaga ctactgctaa

31201
tgaaacttct tctaacccta gttttgtctt atcttcagtt tttccagatt tgctcaaagc

31261
aatcccagtg agcatccacg tcaatgtcat tctcttctct gccatcctta ttgtgttaac

31321
catggtgggg acagccttct tcatgtacaa tgcttttgga aaaccttttg aaactctgca

31381
tggtccccta gggctgtacc ttttgagctt catttcaggt aagtacaaaa ttctacctct

31441
gaagacaaat gtgcttttca atatgtcaaa aagaccgtct acctaaatat aaagttataa

31501
tcttaacata tatacatgga tgcacactgt agtattatac ataataacaa aaagtgtgga

31561
aataccacac ttgctcaaca gtagggaatt caataaatac tttatggaca tctatatgaa

31621
taactgtgat gctgacatta aattatattt ttgaagatgt aatcaagagg ataaacgctt

31681
gtctcaaaaa gttacatggg aaaagcagta tgtaaactta tataaacatt gtgaacctaa

31741
tttgattata tatataaaat atagggaata tacatataaa atacatatat gtatatatgg

31801
gggctatata tatatatata tgaaagagat agatagatag atagatagat agatagatag

31861
acagacagac agacaataca gactccaatc tgttggtcgt ggttgtctct gacccatgac

31921
actatggggg acttttattt ttgctcatac ttttcaatat ttcttagtgt tcaataatgt

31981
gctattattt atacataata ataaaaataa ataaatggca tcaaaaaaga gtaaagggcc

32041
agtgttccgc ccacatatga gcagccatat tcaagcctgt agacactttg tgtagcctaa

32101
tgctaggtgt atctgggcaa ggataaactc taaagccaga aattagttca tcaataaaca

32161
tgtgctactc aatagctagg gctgatggaa aagaatataa aacccagtct gtgccaaatg

32221
gtgcttacta tctgcaagtg ggagaaggag aaagacgaga aaatgaaaaa tgtgtgtata

32281
atttatatgt agcbgttctg taggagatct ctgacttcac cccattctaa ctttgcaaaa

32341
agatccaaca ctttgtcaga ttcctgggag gcaagtaatt ttattgatgg tttcatggag

32401
ggatacagaa cgataacaac tcacacaaag caaacaatgt aatgaaaatc tctattcgac

32461
tgtttctttt tctcctgaag ttgccctttg gctgccagct accaggcacc aggctcaagg

32521
tactttcttg ctcttgacac tactcccttc tctcatacaa ttcaacccca accacaaacg

32581
tgtatagatc tctctctcta taaaacaaag gcctgtagtt aacaggaggt cacttgcagt

32641
gtagcctctg ttcattgtta cttgtgcaca ctgcttaggg tctcacccca tccacattct

32701
gctaatcaca ttattcaccc atccaatgta gatctctcca gtggagattc tgctaatatt

32761
ttctttagat ttgtcacaag tatataatac agttttaaat tgtacagatg attatcctat

32821
aacagaagag tctaagcctt ttacatcttt gtatctctaa cgaaagcatt cagcatgaag

32881
ctctgtacac agcagacaat tcaatatgaa tttgctgact tgaaacagca agcctagaaa

32941
ggagatgtta acttggtcac ttagacagaa caggtttcag caatcagaat tcagatgaca

33001
tggaactggt agaacaggcg ctttgaagca ataggacatg agccagtgag gagagggatg

33061
gaatatcata aacaaaggcc aagggctttg caatcagagc tgaagagcca agagcacagg

33121
ctcagggtgt gggcagactg aatgagaaag tgattcaatc acatgtgaaa gtccagatga

33181
gaagagagag ttgggattac ttctgctcac caaacatcca aaaccaaaca ggtggatccg

33241
ggtggtgtgc tgttttactg atgaccatta cacagaattt taacagaagg aatgtaaagc

33301
agtggttctc aaactggagt tcccagatga gcagcgtctg catcatctgg aaacctgata

33361
aagcagcaaa ttctcaggcc ctaccccaga cccactgaat cagaaacttg ggggtctggg

33421
ggaagatggc catctgtatt ttaacaatct cccttcagga gattctgagg ctggctcaag

33481
tttgaactac aggtagttgg ttcaacaggt gttggtggac tgacaaacaa aaagagactc

33541
cgaggtaact ccaagatggt aatgtcagaa agcagctacc acccctaggg cttgggggaa

33601
ccaacaaaag agtttggcat tgccagaacc tagaatcttg aggagaggcc ccagagcatt

33661
gtgtctcaga ccttgaggac ttggcactgg gacaccatga ggggtttctg ggtgtgggaa

33721
agggctggaa actccccagt tgctgccacc agggagaact acaagtgaag tggaaggtgt

33781
gggcctttct cccttttctt ttctcgtctt ctctctcccc ctggtgctca tgtttgacag

33841
aaaacagctg aaaaggcaga actagtttgg ggagtcttga cctggcatca taaagcagag

33901
aaaagcaaag ctggagtgaa ggtgagacac aacagctcat tagcagcaac agccgtctag

33961
cgctccagct tctgaatgaa attctgaaga acagcgcact tggaagacaa attatttgac

34021
agttctgaca gacgaccaaa ctaacagcat ttgaaaagca agatgactca gagaatacag

34081
aatttaatcc aaatcccaga tcctatctct gcctttggcc aggcctaatg caaggagaac

34141
ctgagcacac aaatatatgc aggaatgatc aggacctgtg cctgcattct attctgtctc

34201
acccaccttc aaatttgttg taaaaacatg ggctcaataa aggtttgtga atcagggaag

34261
gaagagaagg ggagaaagga agggaaggag ccagctccag atctgtgtct tgcagaggat

34321
aaaggccagt gtttttagat cacccagtgt ttttctaagc ccccaatact tattttgaaa

34381
tatcaaaatg ttcaataact aaaaaaaaaa ccgttacaac aataaaacat gtttgagggt

34441
cagatggact ggcagtttgt gacctctggg gataaacagg tcactttgga atcacagact

34501
tcctcattcc ccttaaatct catatggtac ccagaagccc ttggaacttt ggaaggtgtt

34561
tattcacagt tgtaatgtcc atgcagaccc tggctctaag acccaattgt gtaagggtag

34621
gtttgtagcc cttatcccaa acattctaag tgtgagccaa tgcgtcacac actcagaggc

34681
cagagactgt attggggtcc tttatttcac gtacgagtca cattccatta agagacccca

34741
gaagtcagct ctcttccact gactggttct cttcccttgt ttctcttgcc aatgtgtgct

34801
gcccaggtgg cagtgctcac tgtcagcaga gaagaaaaat gctttcctcc ttggacctct

34861
tttctctttt tctcctccct actcacattc aggttcccta agcttccccg ctccttgtgc

34921
tgaagtcatt ctatggtcat ttcttcaact gtctacttcc ctgctggatg ggcacccaag

34981
acttggcatc ctggggcatg tagaaagggg aaagggaagg gaagggaaaa gaagtcctcc

35041
caattgtcta tctggacctt tccacactgc ccagagtact gctatgggca tctccttatg

35101
tctcccgatg tggtgcatgc cagaccctgc aggtagaaaa ggaaagaaag caacccattg

35161
gaccaggcca gcaaaggctt cagtcacaca gctggctcat acttatggct tcatattctg

35221
ttgcctcttg aaccagacat ttcttccact ctcataacct ccagtttagc tcgtattcct

35281
cagcattctc catgtaatat tgttgcatga aacccatgca agtcagccaa tttgctcttt

35341
ctcatcttgt catttataaa ttgatgctga gaagtctttt tcccaaggtt tttagtaata

35401
ccttcatcat cccccatagt tcattttggg cagtgattcg cttctttgac tgtacattag

35461
aatcatctga agaactttct aaaactactg atctcaggtc tcacacaaca ctaattaaat

35521
tatagtctct ggtggggtag ggcttgggca ctgctatttt accttaagct ctctggagtc

35581
attctaattt gtagccagtg ctaagggttg caatataagt gaatatattt cacgtatttg

35641
tcaaacattg actgagtgcc cattatgtgc cagccattat aataggcact ggtgatccca

35701
cagtgaatca ggcacacaat gctgtcttca cggagcttgt tgtctagtgg gagagtcaaa

35761
caaaagtgta tatcaataat taagtgatta cagattgcaa taattacaat aagggtgata

35821
aacaggttgc tataatatac aatagtattg cctttcacca gacatttctt aaagaggtaa

35881
atcatctatc agacaccttt taaaaatctc atctaatttc aaaagtgtac ataaataatt

35941
aagtgattac agtttgcaat aattacaatg agggtgataa acaagttgct atgaaagaga

36001
aagatagcag agatctggct ttgagatggt ggtcagggaa gactgctcca atagctgagt

36061
tctaaagcta agaaggaact gagaaccttc acagaacgtc ccaagtagaa gagaaagcac

36121
actgaagact ctagggaaag aggtctgctt gttgtaggaa ccgaaagaag gccaatgtgg

36181
ctaggtgctg ggtagtgagg ggaaatggca caaggaaaaa atgaggttag agagatcagt

36241
tgataccagt taatgttgga ccctaaacat taaccatggt aagtctttta gaattgattc

36301
taattgcaat gaaaaccttt tgaaagattt taaaaagata tctgatagct gatttacctc

36361
tctaagaaat gtctggtgaa agacaatacc atcacattgg agatggaaaa agatgaatgg

36421
attctaaaaa cattctgaaa gtacattcaa aatgtttttc aggtagctta tgcaactaat

36481
aaatagtggt ggcattctgg gtaagacaag ggaggagcag gcttgcagtt tagggcaaga

36541
aaggggtggg gagaagagct cagcactaaa atcatgtgtt ccatttgggg cacatcgagt

36601
ctgagttgct atgagaccac caagtggaga tgccaagtaa atagtcagtt acatgaatct

36661
ggagttcagt gaagaggtct agaagaaaga tgtatatttg ggcattattc ggatatagat

36721
attatgtaaa gcaataaaat tggatgagat cacctaggga gagaatgcac atagataaaa

36781
actgacctag gaccacttca tgtctaaaac accaaaagca atgtcaacaa aagccaaaat

36841
tgacaaatgg gatctaatta aactaaagag cttctgcaca gcaaaagaat cagagtgaac

36901
aggcaaccca caaaatggaa gaaaattttc acaacctact catctgacaa agggctaata

36961
tccagaatct acagtgaact caaacaaatt tacaagaaaa aaacaaacaa ccccatcaaa

37021
aagtgggtga aggacatgaa cagacacttc tcaaaagaag acatttatgc agccaaaaaa

37081
cacatgaaaa aatgctcacc atcactggcc atcagagaaa tgcaaatcaa aaccacaatg

37141
agataccatc tcacaccagt tcaaatggca atcattaaaa agtcaggaaa caacaggtgc

37201
tggagaggat ctggagaaat aggaacactt ttacactgtt ggtgggacta taaactagtt

37261
caaccattgg ggaagtcatt gtggcgattc ctcagggatc tagaactaga aataccattt

37321
gacccagcca tcccattact gggtatatac ccaaaggact ataaatcatg ctgctataaa

37381
gacacatgca catgtatgtt tattgcggca ctattcacaa tagcaaagac ttggaaccaa

37441
cctaaatgtc caacaatgat agactggatt aagaaaatgt ggcacatata caccatggaa

37501
tactatgcag ccataaaaaa tgatgagttc atgtcctttg tagggacatg gatgaagctg

37561
gaaaccatca tcctcagcaa actatcgcaa ggacaaaaaa ccaaacaccg catgttctca

37621
cccataggtg ggaattgaac gatgagaaca catggacacg ggaaggggaa catcacacac

37681
tggggactgt tgtggggtgg gaagaggggg gagggatagc attaggagat atacctaatg

37741
ctaaatgacg agttattggg tgcagcacac cagcatggca catgtataca tatgtaccta

37801
acctgcacat tgagcacacg taccctaaaa cttaaagtat aataataata aaataaaata

37861
aaataaaaaa acaaaaattg atgtaggacc aattcctgaa gaacactgac agttaatttt

37921
ttggtttagg aggaggagaa gccagcaaac gacactgagt agcaatatcc aaagaaaaag

37981
aggaaaaagg aaaactggga gattatgagt gtcccagagg gaatgtttca agattaccat

38041
cagcagtgag ctttgtgtaa aggtggcctc ctgtaataga ggtgcgggca ggagaaggca

38101
gaatagggaa aagggggtga aaaagcttcc ctcaagattt ataatacagt ggaagagaga

38161
gacagagaga gagaaagaga aagagagaga gagaacttaa ggaggtagag gaagagagag

38221
aaccaaaaaa gagggagctg agtatagaag caattagatt catagttttt agttgcggca

38281
gtgatatttg agtgggggcc ttttatatat tccattctag gtgtttccca gttgatggga

38341
gagggtctta cctagatctg catgtaaaag ggagtaggcc agctggcaga cttgacatgg

38401
atcagtggta gaacatccta gcagttctgt gaatactctc tgagaatgac atgaaaggta

38461
ttggttcagg ccttttggag gtgataaaaa ccaccaaaat gtggacttat tgcaaattgt

38521
atttgttacc atttgcaatg attataatta ttctcttata tataggcttt cttacatata

38581
gcttctctta cacatagcgt catgagttat gccttctctt acatatagtg tctgctatga

38641
gttatgccaa gcagggcaaa caaaattgct gcctttcttt aaaaagagga cgctcctagt

38701
atgggcctaa ttaattatga taattacagc tatggcatgg aacataagca cattcatata

38761
cacaaagaca ataaaataaa gaacagttca aaaacagaac agttacatta tatatcagtt

38821
tcagtatgaa taataccctg gactctgaaa tatgtctggg gcacattatt ctgtaattgg

38881
tggtgaaaaa aaatctgcat cttatctcta cgccaatcct tatgaaggag ctgtttttca

38941
ggagttcgag aaagagacac agggatgtcc agtcatcaaa gccgcagagc ctgaggaaga

39001
ataaaggatt tgtggcagga aaacccagta atgaatgtat tctgctagtt tctcagcata

39061
gaacttagaa aagaggccac agaaggaaaa gagaagtaat gttagacagc tgatgttggc

39121
aatgggcaaa gaatttcatt ctcatatgca gggcagtggc taaaggggca gtgttgtgag

39181
gaatcacatt ccaggtcatt catgtccagg gtgtggtagg aggactgtgt ttcatttatt

39241
ttgtacatgg cccagctatg accttgtgca aggaaatgct taatcatttt ctatcacagt

39301
tgcaaagaga ttcttatcct actcagaatg tacgtcttct cttctgtttc atttacagtc

39361
acaacccaag tccttgcttt gacctccaaa gcaccacttg atgtatccac ttcagaaaca

39421
cacacagaca gctcacctct ttctatccct taccttcctc ccctcttcac tcaaaccacc

39481
tacttccttt gcattcactc ttccttcagc ctgaaataat cttcctccaa atatctacct

39541
tctcactccc tcacttctct caagatacac ttaaatgtta tattccctat gaggcctccc

39601
ctggccatcc ctccccagcc ttcctatccc ccctctctgc tttattttat tctccttaat

39661
atatatcaca ctctgataaa ccattgaatg tacttatcaa gttattgcct ctctctccct

39721
ttccattgtc tccatcactg agagctctgt gaagaaaagg atttgtacct gtttcattta

39781
gtgctgtacc cccagttccc acaacagcgc aacaggcact caataaatag ttgttgaata

39841
agtgaataaa acagaagtag ctgcatattt tctggtaaca aatgatattc ttctgaaaat

39901
gtcatatttt cagacatatt tccgaaaata aattcaaatt agataaacat tgtattttta

39961
gaccatttct tctttgcatt aatcatcctt ctcaataata taacatttgt aaaacttagg

40021
ttagatatgg gctcttcaac tttccattac agaagataaa gtgaaaaggc tagacccaat

40081
ggtgttattc cttcatctac atctatcctt tggaaacaca tgaccaaatt gcttgccatc

40141
acaatctcaa aatctaccct ttggtattaa ctcacttcac ttgtccctct gtcccttttt

40201
agatggtagc catcggtctc tggagcagtg tagagtcaga acaacttcta tttggggaag

40261
aaatcattgc tggtgacctt actttcaatt actaactttc tagtgacatt tacataattt

40321
tagagaaaat taacacctac acttgtaaag ttgtggcttt cccacaccta tttatcatct

40381
ctcaatattc cttgaaaagg aaattatcaa tttatcattc tatattggca atgaaatgcc

40441
cctaatatct gtcacctata agacaattga agatgatgtg ttgaaagctt tctgaaaatg

40501
ctgatcatta ctttaaatgg aattgaaatt ccagtttatt atttccaaaa atatgatctt

40561
actgatcata ggataacatt tcataacatt tcagagattt cttccccttc gaggagccaa

40621
acccatagga cctctggact cccacagatc ctggcaggga gttcccactc ataaaagcac

40681
aggtgccctc agagtcattc agggatgaag aagcaaccct cattggccat gtcctacgtt

40741
ccccatatag taaggactgg aggagaccag tgctcaattc tgcagtctca gacagctgtc

40801
agaggagagt catgaatgtg cagtgtctag cacattacaa acgtttgtta attgactgat

40861
cattcatggt gtgacagccc tataactcag ctatcctatt cagtcagaaa ttaactcagt

40921
aatcaaagtc attaaaagga agaaaaaaaa aacctacagt accagacaga tggtggggaa

40981
atcagacaga tgaaaggaaa aatggctgta ggtcattgag taagacactg ggcagcaaaa

41041
cctgggcctt gtgcctggtt atactccaca ttatagctcc agcaaggttt ggcaggattt

41101
ccacagtcct ggcttattct aacctttctt gggagcagga gcagtgttgg tcagatagac

41161
agacacataa ggaatctgtc caactggcac cgtgtgaatt tgggctcttg gtgtacatgg

41221
ataactggga aaaagaggag agagacatgt aggactgatc ctaccgtttg tgaagtcttg

41281
ggcaagagta tgaatgaaaa cccacttctc ttcccctgcc tggctccact gcacacagta

41341
aagagcctca agcataggtg tgtggacatt gcaccatgta tccaagctct gaccatgcct

41401
cttgaaacag ctattcctca gccaccctct gaccatggga ggaatgaccc aggagaaatg

41461
accacatagg tcttgaaaat gggctcaggg ctatttacga agtcaattcc ggggtcccag

41521
gagtatggac taaaatgtga gtcaggcatg ccagatgggt atgttctatt gacttcaagg

41581
attcctcatg ctgtgggaag gaacctctcc agaagagaga cagagcagaa ccctctaaat

41641
gtggggcaca aagcaggagc ccctcttgct ggattcaaag ggtcatactg gaagagtgta

41701
ggttgagtct tattctcaca tcactcatat cacttacaca cttcttttat agccttagca

41761
gccatgccac aaagagaaac tcttcatgca tatcttttgg tccataagtc ataaatagtt

41821
atccttgatc ccatgtcttt tttagagcca tggacagaga gaagcaaaaa tataccaagt

41881
tcacactgag ttgtctccct tcatatctct tagcagtcac tgaaaggtta tgagactcag

41941
gcbgggtttc tatcctctgt ccctgaaacg acaacgttga cctcgtgatc aaccctagaa

42001
tccagagcaa gatctcagac tgtcctctct actaccagac agcacacttt gttttggggg

42061
ctgtgtgctt gaaatattag ctatggcaaa aggctttgag tcttatgaca ccccaagtaa

42121
cttttacttt aggaatttga aatacagcct tgctgtaatg ctgtctcctt aacaaagcag

42181
tacctttgaa atatttaaca acttgaaaag gaaaccgagc ttgaattttc ctttcaggtg

42241
ctcaggaaat aatgtttcac ttctgtctga aattcaccat ctcctcagac aaagaaggct

42301
cttatggtaa aaggaatggc attttctcca caattttcga ataaaagata aagagaaaac

42361
agcactgcag cctttttgtt aggatctaac aataaagaaa taatacggtt ttgccagggg

42421
agagctctgg ttttaagctc agaatacaaa aataggctga caaaatttta caaaggaata

42481
ttctcagcta ccactctgag gatggtagaa agtgaaattt caagaaaatt atattatttg

42541
attatttgat gatgattaag ctgattggcc agtcctatgt gaaattctaa agtagaagaa

42601
atgtgatgtt gtcttttctg ctcacctctc ccctcattcc tacccccaaa tctctgcctc

42661
taccccaaac ccagcctgac ctttgggaaa ggaatggggg ctgtcacttg caccgtagct

42721
cctcctgcct gcagtactct ccccccacag tccagcctcc ctctgctcag ctaacttttc

42781
ctatagctcc ttctggctac ttctaaggaa ccttccataa tgctgcccac cctctcagta

42841
acagcccctc tactatccct tgattacatg cactgtaatt ggttagtaat tgattttatg

42901
tcctctgcca aattatactc catgagagca aaaatcatga gtattatctt taatgtttaa

42961
atctccacaa ctatccccca tataagtcta gagaataaat gaatgagtga attaatgaat

43021
agaaactcaa gccattatgt tgccactcct aggatatttg gattaacttt aactgaagag

43081
taaaaagcat ttacctgtcc taaaggagac ataaaattag tgggagagta tttggagaaa

43141
aaaaagacac tgtaatacat tcttttgtgt tgcctaccct gatgtagtca ggtgtccctg

43201
atatggggtg ggctgaggat ttgaaataaa atacctaatt tgacattgta agtggaggaa

43261
tcaggatttg aaaccaaatt ggtttgacct aaatcaagct attatgataa ggacttgcaa

43321
gaaaaaagga atccataaaa accatatgaa tagctaccaa ttagtaagca tttatatgtg

43381
tcaattacaa agccaaatgc aaatcatgct ttatttatat tagccacctt ttatagatga

43441
agaaattgag acctgaatat taaaattgcc tacttttaca tagtaagtaa aggaatcagg

43501
gtttgaaccc aaattggttt cacctaaggt agaaaaccat cccagcaagt ctcctattaa

43561
ctggaaccct attgtggtgg cctgagatat aacagtagct gtggaagcgc tgtagagtcc

43621
tggccatcct atgtgctcct gatctggtcc ctcctgccac ctgcttctgc tccctgtgcc

43681
atccacccat ctggaagtct cccagtgtcc atcttcgggg gagacactca ccagagtttc

43741
cagcttccag ccagtatgga gtgcccctgt cccacagcaa tctcaccgaa atcacagcta

43801
catctgttaa aattaggcta ccaatgagtg atagatgagg gggaaaaata ataatagtgt

43861
actaaacaaa acaaatgttt atttttctca cacataaaaa tctagaggtt gaagtccagg

43921
gctggtccag aggctccaag gatctgggat ttagactccc tctttcttgt ttttccacag

43981
catatggctt ccatttctgg ggccacattg gtccaaaatg tatgcbgggg ctccagccat

44041
tgcatccata tttcagccac aggaaggagg aagtggggaa gaaaggacag gcccctaata

44101
cctgtatagt tcaagaagac tatcccgccc atacttccca accaccctta gttgaacaat

44161
gcbgtcttaa ttcaagacac tcacatgtct agccaaaaat ctgaattctg ttacaaacaa

44221
ggagaataga gatgtgcgcc acctcaatac ctcatccata gctacctttt cctttgtgca

44281
gctgtggcca agtgaaagct gaaggagctg tggtaaccct tctgaaggga ggctggggcc

44341
tttcacaaga ggctgcatga ttgacattta tcctgcatgg cctgtgaagt acagagaaat

44401
attttctctt gaagccacat catagcagtg gctgctttgt agcctgattc caccattatg

44461
cctttaaagt gcctagcaat tcagccttca catcatgcaa agaggaatat ctcccagtct

44521
ttgtaagatc agcttaattc taaccacctc cttacctccc actgcactcc tacacgcaca

44581
cacaaatctt cttcactcag agcagaacca taacccaagc cctaccacct agagactgaa

44641
gaatcaggct catgattaca aatatgcaat aattttttgt gtggataatg tcaatgggga

44701
tgatggtaag agaattcctt ggtttacaca ttgaccctct tccctgtccc ttacaatcag

44761
gaaatatttg tcccaacacc ttgtttcttc tgttgcaggc tcctgtggct gtcttgtcat

44821
gatattgttt gcctctgaag tgaaaatcca tcacctctca gaaaaaattg caaattataa

44881
agaagggact tatgtctaca aaacgcaaag tgaaaaatat accacctcat tctgggtcat

44941
tttcttttgc ttttttgttc attttctgaa tgggctccta atacgacttg ctggatttca

45001
gttccctttt gcaaaatcta aagacgcaga aacaactaat gtagctgcag atctaatgta

45061
ctgaaaggca aacctttcta taattttaca agggagtaga cttgctttgg tcacttttag

45121
atgtggttaa ttttgcatat ccttttagtc tgcatatatt aaagcatcag gacccttcgt

45181
gacaatgttt acaaattacg tactaaggat acaggctgga aagtaaggga agcagaagga

45241
aggctttgaa aagttgtttt atctggtggg aaattgcttg acccaggtag tcaaaggcag

45301
ttgactagaa tcgacaaatt gttactccat atatatatat gtgtgtgtgt gtgtgtgtgt

45361
gtgtgtgtaa gatgtcttcc tatcaaaaag atatcaaagg cacatggaat atattttaat

45421
aaaaacaaat aatatctcta atatatccac acatttgttg ccagatttca gaaaactgag

45481
ctgcaatcgc tttcctaaaa cagtagtgta ttaaatgaac atctataaaa tgtatcaaca

45541
cacattttaa aaaatttgtt taaagtatac tcttaggcca ggcgtggtga ctcacacctg

45601
taattccagc acttcaggag gccaaggtgg gaagatcatt tgagttcagg agttcgagtt

45661
acagcctggg caataaagtg agaccctgtc actaacaaaa ttaaaaaata aaataaatat

45721
aaaatatagg ctttaaaaaa gcatagtctt attaaccatg tctgttggtc aaaatctgca

45781
aactctaaaa gaagaaaaga agaaaaaacc aagcttaggg tatttttcct cccgtgcctg

45841
agtcccaatt acattcacga cagtactttc aatgaacata attgttagga ccactgagga

45901
atcatgaaaa atgatctctg cttagtacat ttgatgcaaa atgacttatt aggggctgtt

45961
tttctagcta tagtgtctcg agtactaata tgcaattatg aaaattatat taaatctggg

46021
attatgacgg tatcactgta tcatcttggt cttgttctgg ctgtcaccaa gcatgaccca

46081
ggtcaacttt ttttttcccc tgaattaccc atcaaattga tctgcagctg actaaaggcc

46141
acagctgagc ctggaactga cccttccttc atcctcaacc tgctgtcctc cagaaagcac

46201
caaggaaaaa gcagagaatg acagcaaaca gatcactagg cctctgacca caggtgctga

46261
gtactcagca gccctcatat aataggtttg aaagtactcc ttaaaataaa acactgtttc

46321
cctttggaac tatttacaag gatgaaacaa ccgtatacct gagaaataac ttgctctggt

46381
gtcaattcgc tattcgccag cagacatcag aacacaccga gtttccagat gctggttttt

46441
ccccttaaat caggaaatac acctggacaa tttctagaag actacaattc agtctagcca

46501
caaaggggat tttttttttt tggtaacagg ctagagcccg gttctgtaag tctttagctg

46561
aaatggtcca gtacaaaagc actggaaatg agtgggctag gaggacaagg accgtctcct

46621
gcgtgaggag ttggttggag gtccccaagg ccaggtaccc cctgcactct tattggattc

46681
ctctctgtct tcttggagtt ttgaaaaact ccttcgaaca ccaggctttt ttctttagaa

46741
aacaagtctc caatcgttct ctgttccgta gaaagagaaa gaaaacctgg agcagctgct

46801
gaaaaatcta atgaggaact aagaggcaaa cccacca

A non-limiting example of a human wildtype CLRN1 genomic DNA sequence is SEQ ID NO: 47. The exons in SEQ ID NO: 47 are: nucleotide positions 1-544 (exon 1), nucleotide positions 28764-29180 (exon 2), nucleotide positions 31239-31418 (exon 3), nucleotide positions 32481-32519 (exon 4), nucleotide positions 44799-46433 (exon 5), nucleotide positions 44799-44935 (exon 6), and nucleotide positions 46128-46837 (exon 7). The introns are located between each pair of these exons in SEQ ID NO: 47, i.e., at nucleotide positions 545-28763 (intron 1), nucleotide positions 29181-31238 (intron 2), nucleotide positions 31419-32480 (intron 3), nucleotide positions 32520-44798 (intron 4), and nucleotide positions 44936-46127 (intron 7).

Transmembrane Channel-Like 1 (TMC1)

The TMC1 gene encodes “transmembrane channel-like 1” (TMC1). TMC1 is a calcium-dependent chloride channel and interacts with transmembrane O-methyltransferase homolog in the stereocilia of hair cells. Mutations in TMC1 may lead to non-syndromic sensorineural hearing loss. For example, a D572N mutation in TMC1 has been associated with deafness (Kurima et al., Nat Genet 30:277-284, 2002, and Wei et al., J Transl Med 12:311, 2014).

The human TMC1 gene is located on chromosome 9q21. It contains 24 exons encompassing ˜314 kilobases (kb) (NCBI Accession No. NG008213.1). The full-length wildtype TMC1 protein expressed from the human TMC1 gene is 760 amino acids in length.

An exemplary human wildtype TMC1 protein is or includes the sequence of SEQ ID NO: 48. Non-limiting examples of nucleic acid encoding a wildtype TMC1 protein are or include SEQ ID NO: 49.

In some embodiments of any of the compositions described herein, the TMC1 protein comprises a sequence that is at least 75% (e.g., at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%) identical to SEQ ID NO: 48.

Human TMC1 Protein (NCBI Accession No. NP_619636.2)

(SEQ ID NO: 48)

MSPKKVQIKVEEKEDETEESSSEEEEEVEDKLPRRESLRPKRKRTRDVINEDDPEPEPEDEETRKAREKER

RRRLKRGAEEEEIDEEELERLKAELDEKRQIIATVKCKPWKMEKKIEVLKEAKKFVSENEGALGKGKGKRW

FAFKMMMAKKWAKFLRDFENFKAACVPWENKIKAIESQFGSSVASYFLFLRWMYGVNMVLFILTFSLIMLP

EYLWGLPYGSLPRKTVPRAEEASAANFGVLYDFNGLAQYSVLFYGYYDNKRTIGWMNFRLPLSYFLVGIMC

IGYSFLVVLKAMTKNIGDDGGGDDNTFNFSWKVFTSWDYLIGNPETADNKFNSITMNFKEAITEEKAAQVE

ENVHLIRFLRFLANFFVFLTLGGSGYLIFWAVKRSQEFAQQDPDTLGWWEKNEMNMVMSLLGMFCPTLFDL

FAELEDYHPLIALKWLLGRIFALLLGNLYVFILALMDEINNKIEEEKLVKANITLWEANMIKAYNASFSEN

STGPPFFVHPADVPRGPCWETMVGQEFVRLTVSDVLTTYVTILIGDFLRACFVRFCNYCWCWDLEYGYPSY

TEFDISGNVLALIFNQGMIWMGSFFAPSLPGINILRLHTSMYFQCWAVMCCNVPEARVFKASRSNNFYLGM

LLLILFLSTMPVLYMIVSLPPSFDCGPFSGKNRMFEVIGETLEHDFPSWMAKILRQLSNPGLVIAVILVMV

LAIYYLNATAKGQKAANLDLKKKMKMQALENKMRNKKMAAARAAAAAGRQ

Human TMC1 cDNA

(SEQ ID NO: 49)

atgtcacccaaaaaagtacaaatcaaagtggaggaaaaagaagacgagactgaggaaagctcaagtgaaga

ggaagaggaggtggaagataagctacctcgaagagagagcttgagaccaaagaggaaacggaccagagatg

ttatcaatgaggatgacccagaacctgaaccagaggatgaagaaacaaggaaggcaagagaaaaagagagg

aggaggaggctaaagagaggagcagaagaagaagaaattgatgaagaggaattggaaagattgaaggcaga

gttagatgagaaaagacaaataattgctactgtcaaatgcaaaccatggaagatggagaagaaaattgaag

ttctcaaggaggcaaaaaaatttgtgagtgaaaatgaaggggctcttgggaaaggaaaaggaaaacggtgg

tttgcatttaagatgatgatggccaagaaatgggcaaaattcctccgtgattttgagaacttcaaagctgc

gtgtgtcccatgggaaaataaaatcaaggctattgaaagtcagtttggctcctcagtggcctcatacttcc

tcttcttgagatggatgtatggagtcaatatggttctctttatcctgacatttagcctcatcatgttgcca

gagtacctctggggtttgccatatggcagtttacctaggaaaaccgttcccagagccgaagaggcatcggc

agcaaactttggtgtgttgtacgacttcaatggtttggcacaatattccgttctcttttatggctattatg

acaataaacgaacaattggatggatgaatttcaggttgccgctctcctattttctagtggggattatgtgc

attggatacagctttctggttgtcctcaaagcaatgaccaaaaacattggtgatgatggaggtggagatga

caacactttcaatttcagctggaaggtctttaccagctgggactacctgatcggcaatcctgaaacagcag

acaacaaatttaattctatcacaatgaactttaaggaagctatcacagaagaaaaagcagcccaagtagaa

gaaaacgtccacttgatcagattcctgaggtttctggctaacttcttcgtgtttctaacacttggagggag

tggatacctcatcttttgggctgtgaagcgatcccaggaatttgcacagcaagatcctgacacccttgggt

ggtgggaaaaaaatgaaatgaacatggttatgtccctcctagggatgttctgtccaacattgtttgactta

tttgctgaattagaagactaccatcctctcatcgctttgaaatggctactgggacgcatttttgctcttct

tttaggcaatttatacgtatttattcttgcattaatggatgagattaacaacaagattgaagaggagaagc

tagtaaaggccaatattaccctttgggaagccaatatgatcaaggcctacaatgcatcattctctgaaaat

agcactggaccacccttttttgttcaccctgcagatgtacctcgaggaccttgctgggaaacaatggtggg

acaggagtttgtgaggctgacagtctctgatgttctgaccacctacgtcacaatcctcattggggactttc

taagggcatgttttgtgaggttttgcaattattgctggtgctgggacttggagtatggatatccttcatac

accgaattcgacatcagtggcaacgtcctcgctctgatcttcaaccaaggcatgatctggatgggctcctt

ctttgctcccagcctcccaggcatcaatatccttcgactccatacatccatgtacttccagtgctgggccg

ttatgtgctgcaatgttcctgaggccagggtcttcaaagcttccagatcaaataacttctacctgggcatg

ctactgctcatcctcttcctgtccacaatgcctgtcttgtacatgatcgtgtccctcccaccatcttttga

ttgtggtccattcagtggcaaaaatagaatgtttgaagtcattggagagaccctggagcacgatttcccaa

gctggatggcgaagatcttgagacagctttcaaaccctgggctggtcattgctgtcattttggtgatggtt

ttggccatctattatctcaatgctactgccaagggccagaaggcagcgaatctggatctcaaaaagaagat

gaaaatgcaagctttggagaacaaaatgcgaaacaagaaaatggcagctgcacgagcagctgcagctgctg

gtcgccagtaa

A non-limiting example of a human wildtype TMC1 genomic DNA sequence is SEQ ID NO: 50. The exons in SEQ ID NO: 50 are: nucleotide positions 1-113 (exon 1); nucleotide positions 56102-56223 (exon 2), nucleotide positions 94568-94677 (exon 3), nucleotide positions 106121-106263 (exon 4), nucleotide positions 126797-126864 (exon 5), nucleotide positions 166909-166956 (exon 6), nucleotide positions 172743-172914 (exon 7), nucleotide positions 178718-178843 (exon 8), nucleotide positions 218319-218409 (exon 9), nucleotide positions 220644-220725 (exon 10), nucleotide positions 230050-230156 (exon 11), nucleotide positions 232986-233084 (exon 12), nucleotide positions 250613-250755 (exon 13), nucleotide positions 266539-266683 (exon 14), nucleotide positions 267323-267517 (exon 15), nucleotide positions 270086-270265 (exon 16), nucleotide positions 270391-270552 (exon 17), nucleotide positions 283582-283710(exon 18), nucleotide positions 294343-294410 (exon 19), nucleotide positions 299042-299281 (exon 20), nucleotide positions 305069-305194 (exon 21), nucleotide positions 308651-308729 (exon 22), nucleotide positions 308831-30882 (exon 23), and nucleotide positions 314151-314551 (exon 24). The introns in SEQ ID NO: 50 are: nucleotide positions 114-56101 (intron 1); nucleotide positions 56224-94567 (intron 2), nucleotide positions 94678-106120 (intron 3), nucleotide positions 106264-126796 (intron 4), nucleotide positions 126865-166908 (intron 5), nucleotide positions 166957-172742 (intron 6), nucleotide positions 172915-178717 (intron 7), nucleotide positions 178844-218318 (intron 8), nucleotide positions 218410-220643 (intron 9), nucleotide positions 220726-230049 (intron 10), nucleotide positions 230157-232985 (intron 11), nucleotide positions 233085-250612 (intron 12), nucleotide positions 250756-266538 (intron 13), nucleotide positions 266684-267322 (intron 14), nucleotide positions 267518-270085 (intron 15), nucleotide positions 270266-270390 (intron 16), nucleotide positions 270553-283581 (intron 17), nucleotide positions 283711-294342 (intron 18), nucleotide positions 294411-299041 (intron 19), nucleotide positions 299282-305068 (intron 20), nucleotide positions 305195-308650 (intron 21), nucleotide positions 308730-308830 (intron 22), and nucleotide positions 30883-314150 (intron 23).

Human TMC1 Gene Sequence (NCBI Reference Sequence: NG_008213.1)

(SEQ ID NO: 50)

1
cagaaactat gagggcagaa cccagcaatc tgtgctttct ttcacaagcc ctccaggagt

61
tgctgaaatt taggaatcat tgccccaaaa agtggccctc ataatgatgc caggtaagga

121
aagacaacat tattacctat gtgtggtgtg ttaacattct ttatgaaaca tgtgtgaaga

181
cctaaatcga agactttctc catgagatat tccctaatca cattagtgaa ataaaactat

241
atttcctcta cttttctact gctacagaaa tctcccccag ttaggatagt cccagtttcc

301
tatttatctt tgtttttctt gcagtgcaca gcatgtcacc cagtaattga taagtttttt

361
tttttttgag acggagtctt gctctgtctc ccaggctgga gtgcagtggc gcgatctcgg

421
ctccccaagt agcbgggact acaggcgccc gccatcacgc ccggctaatt ttttgtattt

481
ttagtagaga cggggtttcg ccgtgttagc caggatggtc tcgatttcct gacctcgtga

541
tccgcccgcc tcagcctccc aaagtgctgg gattacaggc gtgagccacc gcacctggcc

601
taattgatat gtttaaatgt taaaattaaa tgcaatgatt tcctaaaata aacaaatgtg

661
ggacaattta ttgcactctg ttcaaattcc cattttgaag tggaattcaa acaaacatga

721
cagtaaaggg ggacagtgag cacagggaca agagaaaagg agaaagggaa gaaatacaga

781
gaactagata ggaggaagtg tcaaagactg atgggtgtaa gccaccttta cctctggata

841
ttggttttcc tttgaattgt ggtatgtggt catattgctt attagttata acatacagct

901
gtcagaagag tttttcaatt aaaatttcaa atgtaatatt aaaactgttt ggattccttc

961
ctactgggca ctggacactg tctgtggagc tgctggaaca gcgctgaata gggtcatatt

1021
ttaaaggaac tcagcctagt gcagtttctc aaccttagca ctattggcct ttggggcctg

1081
ataatccttt tttgtgaggg gctgtcctgt gcactgtagg atgtttagca gcatccttgg

1141
cttctactca gtagatgaca gtatcaaccc ccttccccag aagtgacaat taaaaatgtc

1201
tccagacttt tccaaatgtc ccctgaggag caaaattgtc tccagttgaa aaccactggg

1261
ttagtgggag aaacagataa gacagaagtt ctccatacac catgataatg ccatgatgcc

1321
atagggctgg caggagtgaa gggaagagca tctcacaaag actcgggggg atgcagggag

1381
gaggaaaaat taggaaatga agtgggctga gttgcagtta gcctgtgggg aaaatgaagg

1441
agaagggata aggaagaaga ggaggaagga gggaggaaga gtgaggagta atagggaatt

1501
atagttgacc ttgaacaact tggggtttag ggatgccgac ccttgcgtag tcaaaaatct

1561
gagcttaact tttgactacc ctcacacttt cctaacagcc tactgttgac cagatgcttt

1621
accaataaca taaacagttt attaacacat attttgtatg ttttatgtat tatacactgt

1681
attcttacaa taaggtaagc tagagaaaag aaaatgctat taagaaaatt gtaaggaaga

1741
aaaaatatat ttactgttca ttaaggggaa gtagatcatc ataaagctct tcatccttgt

1801
catcttcaag ttgaataggc tgaaggagga gggggagaga gaagagactg gccttgctgt

1861
cttaggggtg gcagggatgg tagaggtgca ggaggtggaa ggggaggcag gaaaggcagg

1921
cacactcggg gtagctttcg ttgaaagaaa tcttcatatg agtggaccca tgcagttcaa

1981
acctgacttg ttcagagtca actgtacttg ttccaggcta agaacagaga ataaaaaaaa

2041
aatgtataga ggcctgaaac agcatattat attaaaagaa ctcaaagccg gtaaatgctt

2101
tgctactgaa gcataaagtg agaaaggggc atcatgggct ctgaaattgc agccacaagt

2161
ctacagaaca catttttcat agcccaaggt cagtcttcta ttaccctttg cagtgaggtt

2221
atcatcatcc attttcactc gtcagtgctg gggagcccat taaatacttg ccactatact

2281
tggtcccaac agttaataga ctgtagcatc ttttatttct tcacctagcc tgaaatcagt

2341
tgagcttttg cagaatctta gatatgtcgt ttttttcttc aggtttagaa tggggcactt

2401
aaaaagatgc atagtacttg aaaatagaga aagaaaatag catgtagaaa tttgtgcctt

2461
tattctgccc aaacgtctca aaaaggaaaa aaataatttt aagggtaaat attgtcatca

2521
atttatctga gctcttttga cttcctttga gcctgaaaaa caggatcagt gtctttttag

2581
tatttaccat agtgcctgat atgtagaagg tgtttgacca atgtttatta gataaatgtt

2641
cacttttatt actagtaata ttaaccacat tttaatagag actaataata catgataaac

2701
ttctcaagga tgcgatctca tttgatcact ataacaaccc aatgaggtaa gcgaggaata

2761
gttgttaact ctaatacatg ttatatctta tccttgaccc agtattaccc cagtcatgcc

2821
ttcctttccc tgcaatgaaa gaaaaccgat aaacacaaaa tgttgtatcc catataagca

2881
ttcattctta tggtagataa gtaaatggaa aagataggta tgcattctca atttttttaa

2941
gtcctagaat tataaaacag taaagaagtg agaagagaga gaaatcttaa gggaccaacc

3001
tcttgatttt acaggtgaga aaactgaggc cacatagcca tttagtgcag agccaggatt

3061
ataaaccaga tgtttggaat cctatgtggt ggtggacacg aggatatact aattagcgtc

3121
gttaccggaa aattccacat atctctaagg agcagatcac cacacacctg cacagcccaa

3181
gcctggattg tggaggtttt tcttgtagag tttgtctttg atagaaagat acggtccaga

3241
aggccggctt caaggacata agaaagggca tattcaaaac aaatacatgt atgcctattc

3301
ttttaaaccg gtacttaaca atagtatcca ggtgtccaaa tataatagct tatctgtttt

3361
attttttcca gaaaaggaaa caaggtctta gagaggttac attttgcata ggattttgtt

3421
agccaagtca gcatctgttt gcatcttaaa aatgagtcat acctattcct tgtaagtagg

3481
acaggagggc agctggaatt tcccagctca ctccttgtca ctgcttcctg cctctgctgc

3541
tctttgtcct ccacagcacg cttcattggc taaaaagtga accagatact acattacctc

3601
agggcagttg taagtactga gtcagatgcc ttaggcttgt gtgatgggaa gtttagggcg

3661
agaccaatgt cttgctttaa caacagtgtg aataagttaa tttcttttga gattttatta

3721
ctcaatattc cacccagaaa gaaacacaga tgacactcag ccaatcaaag gccatctggg

3781
actgacaaac gcagagcttg ttgtagatga caaggctcag tggatggatc atcactgaaa

3841
gaaagggaaa cagtttgaac tgttgtatct ctctccttgc tcacatgaaa aacaaaaaaa

3901
tccttggcca gttgcggtgg ctcacgcctg taatcccagc actttgggag gcccaggcgg

3961
gcagatcact tgaggtcaga agttctggac cagcctggcc aacatggcaa aaccccgtct

4021
ctactaaaaa tacaaaaatt agccgggcgt ggtggcacac acctgtattc ccagctactt

4081
gggaggctga ggcatgagaa ttgcttgaac ctgggaggtg gaggttgcag tgagccaagg

4141
tcgtgccact gcactccagc ctggatgaca gagtgagact ccgtctcaaa aaaaaaaaaa

4201
aattccttaa ccacagacta agtaagcatt attgcacaga gtgtcattcg ctaatcttgc

4261
ttgtgcctga actttgaaag caccagcccc ttgctttggg ggcbgggggc gtggggtgta

4321
agtgtgtgtg tcctctagaa gaagacaaca ctgagaacag aaggagagga tcttggagat

4381
ttgttaattt cctattgcag ttagccttgt ctggggctct cactttagca cttaaaataa

4441
catactcctt tgcacagatg ttattttttt ctcttcatgt gtacaacttg aattatccaa

4501
tggccttgct ttgaggatat tcatcctatc ttattgatcc tgtcactgtg taggacaatg

4561
gagaacacag taaaaaaccc tcaatggata ctacttacac taaattaact ctatgaattc

4621
aaaatttgaa gatgctactt aatcatgtaa gcctggttct ccaaaacttc atctgccatg

4681
ggaaaaatca aagcttgtaa aatgattaaa cttgtaaagg aattaaactc taggattcac

4741
tcattttata attggtattt tcaccctaag agctttcttt ttcctctctg gtgtttaaaa

4801
acaaagtaaa accagacaaa acaagattaa ctaaattaaa acccctgtga ctttaaaaaa

4861
tgtagccaag aataatgtgc aagtgtctag ttaggccaat agatatcctt aacatacgtg

4921
agcbgggaac acaaatgagc atgaagggca aggaagagca ccaccccctg cttcttttcc

4981
tgctcctgtt cttgcagagg gtcaggcttg gagaccacat atggtcagct caacactcaa

5041
gtccaccaag cagcccatga ggaactcttc cttccagagt tgtgcacacc atgcagtgtg

5101
gtccacctgc agaagcacac aacaggcgct gcctgggcca gaggtccatt caggccatgg

5161
aattggtctc aatgccattt aggcatgaat ccagggtcct gggtaccaga cgcatggtct

5221
aggtaggggg tgtcatgtac taggtgagca tggggttccg ctgggcatgt tcccttgtct

5281
tgtaggatgt tagctctgag gggcgtggct ggaagaaggc tagccttgag ccctctaaaa

5341
ggcagggctc agggcaaagc tcccagttgc tcaggcctgt gggtaatact gcttaaaaat

5401
ccccttgaga acttctttaa aatgcaaata tctcgattct tttgtagttc aaaagcatga

5461
tgattgggtg ttcacaggca tgtgtaagac gtgacaccct ctgaacctcc ttatgacccg

5521
gtacattacc tgtctgacct gaaaaaaaaa tgcaaatttc tggattctac ccgcctcccc

5581
gcactccgac attacgatgt agcagctctg tggtaggatc caggaatctg cctgtgtaat

5641
cacaggttga tattctggtg tttcctggtt ttgctctgct gatttggggg atgtttacca

5701
gcaggagagc agcctctttc ctctgccctc ctcccttgct gccctcccca gaccccagtg

5761
actcacgctc ctcctgctcc tcctgttgct ggcctctctg ttgtggttgc cagcgctact

5821
ttgcagacgc tgcctgctcc ctgcacgcca acacagattc tgtttccctg cgaccgctgc

5881
tgctgttgtt tgttccgtcc ctggtttatt gtaggagagc tgattgttct gttgccactg

5941
ctaccaagct gcaaacacca ggctcacggt gcaaggggaa ggggcttctc ctctgggtgt

6001
tctgcctcta tcgcctaggc tctcaggctt tgttgccaat ggcactgcga gaccctaaac

6061
tatggccttg tgattcccac atctccattt agttctttct tttgttctct aagatctgag

6121
aaggagccca tgtctttcag tgttcctgtt ttcttgcgat acttcccccc tccccgactc

6181
cagaatttag ggcaaccttc tgcbgtggtc tgaatgttta tttctctcca ccccgccaaa

6241
cttatatgtt gaaatcttaa cccctaaggt ggtggtatta gaaactgaag cctctgggag

6301
gtaattaagt tataaggaca aagccctcat gaatgggatt actgttctta taaaaaaaag

6361
gccccagaga gctagctagc tccttccacc atgtgaggac acaacgtgaa ggtgctgtct

6421
atgaggaagg gtccctcacc agacaccaat catctggcac attgatcttg aacttcctat

6481
cctccagaac tgtaaacaaa taaatttctc ttgcttataa accataagtt catgattttt

6541
tttttttttt tgagacggag tttcgctctt gttgcccagg ctggagtgca atggtgtgat

6601
ctcggctcac aacaaactcc gcctcccggg ttcaagcgat tctcctgcct cagcttccca

6661
agtagcbggg attataggca tgcgccacca tgcctggcga attttgtatt tttggtagag

6721
acagggtttc tccatgttgg tcaggctggt ctcgaactcc tgacctcagg tgatccaccc

6781
gcctcggcct cccaaagtgc tagggttaca gatgtgagcc actgcacctg gccaagttca

6841
tgatttttgt aattagcatc caaaatggac taaaaccccc atcctcctga aggttctgaa

6901
tctgaggacc caagacttgg ctctcagcct taatgtcctg ctcccactat tttcaggggg

6961
cccaatataa atttcctgag tttttgaggt ggttgggctt gcagactgac ctttagtatg

7021
ccctttgtta catttacaaa atagattgct tacagggtta gacaaataca gttgaccctc

7081
tgtatccctg ccttccatat ccatgggtca aaattatttg gaaaaaaaaa tgtgtctgta

7141
ttgaacatgt atagattttt tttttgtata tttcctaaac tatatcgtat aataactact

7201
tacagagcat tcatattgta ttaggcatta taagtagtgt agttatgatt taaagtatgt

7261
gagagaatgt gcacaggtta tacagaaata ctacaccatt tttttttttt taatcaggga

7321
ctgaagcatc ttttcagcta tgactttggt atccggtggc gggtggggcg gtgggtgggt

7381
cctggaacca ttcctccatg aataccaagg gataactcta attgctaaat cgtttcctat

7441
ttttgtgaac tggtaaagga ctgcatgaga aaggccaaaa attaaagaat aatatgctta

7501
ttcaagcccg gtgtggtggc gggcacttgt agtcctagct acttggaagg ccgagatggg

7561
cccaggagtt tgaggctata gagggctatg gttgcacctg tgaatagtca ctgcacacta

7621
gctcgggcaa catagctaga ccctgtctct aaaaaagaaa aattctgctg taataaacct

7681
gcacgcataa aatgatgtct atgtgtctat atagtgtgta tatacatatg tgtttaggaa

7741
atgtgtatat atgtgtgtgt gtttgtgtgt gtggatactg tattagttaa gacaaaaaaa

7801
tctggcttca tatgttataa aataatgtct ggagctatcc actcaagtgt gctttcttgt

7861
ttctctgttt tttttttttt cctatttcat tcagtggttt tcactgcctt tgggaaaaag

7921
tgacacagca aaacacttag aagaatcaaa tgtttatcct ttgagaatgt ggtctgtaca

7981
taagagaaaa catttagaat caaattatga gactaaacca gtttccctca cctgcagcta

8041
gataaaaatt tctaagagga aggagagaat caggaaagat tgaagacttg actccctgat

8101
aagggttctg cccgagttct gagaatggag aataaaagac accctccccc tctctaatag

8161
attttgtcag tgaaggtcag agaggcccac gaaatcaggt ctggggagca aggtaaaacc

8221
cagaatttct acatgatcat gttaaagagg gaataaagga atatcattat agtgtatctg

8281
ggcaggtggg catgagacag cctgattgag ttcctgaaat cccaggtcgg tgtgggagca

8341
gcagaatatt ttaggtggct gagagctcca tagtttcttt ctttctttct ttctttgaga

8401
tggagtctca ctctgttgcc caggctggag tgtagtgacg cgatctctac tcactgcaac

8461
ctgtctccct ggttcaagta attatgtctc agcttcctga gtagcbggga ttacagatgt

8521
gtgccaccac acctggctaa ttttttttta tttttagtag agatgggatt ttatcatgtt

8581
gcccaggctg gtctcaaact cctgacctca agtgatccac ctgcctcagc ctcacaaagt

8641
gcbgggatta caggtgtgag ccaccagcag tcccagctac tcaggaggct gaggcagaag

8701
aatcgcttga acccgggagg tggaggttgc agtggaccga gattgtgcca ctgcactcca

8761
gcctggtgac agagcaagac tccatcttaa aaaaaaaaaa accttctcaa ggtattttct

8821
gtgcttcttg ttttctcttt tgtatttttc atctttatat ctttgtgttt cattctggat

8881
aacttttagt gacctgtctc ctagttcact aattctcttt ttagctatgt ctagtattat

8941
aatttgttta ttgaattatt aagtttaggt atcaaatttt cagctttagg atatctaatt

9001
tgccacttgt tttctgccat gatttttttt ttttttttga ggtggagtct tactctgtca

9061
cccaggctgg agtgcactgg tgtgatcttg actcactgca agatctgcat cccgagttca

9121
catcattctc ctgcctcagc ctctcaagta gcbgggacta caggcgcctg ccaccacgcc

9181
cagctaatta ttattattat tattattatt tgtattttta gtagagacag ggtttcacca

9241
tgttagccag gatggtctcc atctcctgac cccatgatcc acccaccttg gccttccaaa

9301
gtgctgggat tactggcatg agccactgca cctggcttct gccataattt ttaaccttga

9361
gttttaccta cttaaacata gcaaacacag ttgtttatat atttatctaa taattccagt

9421
atcaggagcc tctggagtct acttttgtct actttcattg ttttttgttt tttaaattta

9481
cattaacagt gtctagtctg tatttatgcc tggttacttt tgattgtgtg ctagacattg

9541
tttttggcaa ataatttttt aaacacaata tgtacaaatc atatgaagcc tagactggtg

9601
ttttgttcac caaaaaagat tttaaattac ttcagttacg ttcctaggga cactattaac

9661
tcaggatgat gttaattgaa gtttcagatt tgatattttc caggtcaact ggaccaactg

9721
tccctgctat atgatttatt tcctaaagca atatcaagtt cagctctgca cctctcttat

9781
atactatgga gctctcagtc acataaaata ttctgctgct ctcacactgc cctgtagttc

9841
ataagaggaa cagtttactg ttaatccgta ttactcttac atctagggtg tagctctttg

9901
agctaccagt ccaaagtgaa gaataattta ctgaattcct actttgtctg gctctaggca

9961
ctgatttttt ttaccctctt ggccacctat cttcaattgg aaaatgccct caattcaaaa

10021
atgctccaag tgccaagctt tcctatctga attcccattt tttcctgtat ctggctggca

10081
attcattaga atcctgctag ccctctgatg cttctaagat tttcatcttt tatttttatt

10141
tatttattcg agatggagtc ttgctctgct gcccaggctg gagtgcagtg gtgtgatctt

10201
ggctcactgc aacctccatc tcctagggtt aagtgattct cctgcctcag cctcccaagc

10261
agcbgggact acaggcatcc accagcatgc ccggctaatt ttgtattttt agtagagatg

10321
gagtttcacc atgttggcca ggctgatctt gaactcctaa cctcaggtta tctgcctgcc

10381
ttggccttcc aaagtgttgg gtttataggc attagccacc atacccagcc tgaagttttg

10441
attaaaaatg ctttactggg ctgggcatgg cagctcacgc ctgtaatccc agcactttgg

10501
gaggttgagg cgggcagatc acttgaggtc aggagttcga gaccagcctg accaacatgg

10561
tgaaacccca tctctactaa aaatacaaaa attagccagg tatggtggtg catgcctgca

10621
atcccagcta ctcaggaggc tgaggcagga gaatcgcttg aatctgggag gcagaggttg

10681
cagtgagccg agatcgtgcc actgtactcc agcctggaca acaagagcga gactccgtct

10741
caaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaactt taccggaatt

10801
aaagcccagt catcttgaag ccatgatcat gacgcbgtgg aagaaccggt gaggtaggat

10861
gagacatatt ctcagatgct atgctgattt ggggcbgtga tgattttgga ccatagacta

10921
tgatgaggct tcaaaaagag tgcaatagtg tattttaatt tctttggtta gattcaaatt

10981
aatcttcaga aagacaaaat gcagatgtag tcttgttaga gcttgctgat gagactaaat

11041
tttccaagtg tttgaggaat gcctaacagg ggaaaggcaa agcaaactat ttttaatgac

11101
cttatggctc tgaattgcta aaagggagtc agtccaccag gctcaggcta cttggagtag

11161
aggatcctgt ttcagtgaca aactggctca tcccttaatc tgccataaaa tgatggctta

11221
gcatacatgt aggagcbggg gctaagggag aaggaggtgc tgtgttttgc agaagaagct

11281
acattctgta gtaaggcctg actcttccct ggccttggag gggaaatact tgtgagacag

11341
tggccaggat cagctgaagt gccctctctt cttgctttgc ctatgggaca ctgagcccct

11401
ttttgtggaa tatattcatc cagagaaccc tcacacctta taatgcataa agtgataaag

11461
gcttggagat ctggagaaac ccaaggtgcg atccctggct ctagaagaaa ctctgggcag

11521
ccagcatgat ttacttttct ctgctccaaa gactggagga taaattaaag gaaaagaggg

11581
tatgacccag caatccactg gtgcgagttg ttgctttaag caaagactac tgcttctctt

11641
cctgattttc ccctgaccat actctcccag aggtgtctcc cagcaaccac cagagttgtg

11701
gttaagtaca cctagccaat ccaataaatc taaaggagat gcagtccaca caaccttgca

11761
tgacttgtca tgtgagttac tgttctggag agacaaactc aggctggaaa cttatttgag

11821
atagcttatg aaaacaaaga taatttatga taaggataca ggcactctca tacaatctaa

11881
ggtagaaaaa cagctaagca tcagaacaaa ctggaccaaa gacttaaaca cttctgctcc

11941
tttgtgtaat tggtttcatg cgtttctctc tctcccttcc tctctctctt ttctctctgt

12001
ggactaggtt tttctacttt tcatatacaa attttaaaaa tacaatttct ggccaggtgc

12061
agtgactcac gcttgtaatc ccagcacttt gggaggccga gggaggtgga tcacttgagg

12121
ccaggacttt aagaccagcc tggccatcat ggtgaaactc catctctatt gcaaatacaa

12181
aaattagccg ggtgtgatgg tgcacgcctg taatctcagc tacttgggag gctgaggcag

12241
gagaatcgct taaacctggg aggcagaggt tgcagtgagc tgagattgtg tcactgcact

12301
ccagcctggg taacagagtg agaatctgtc tcgaaataaa tgaataaata agtaaaataa

12361
acaataaaaa taaataaaga caattttaaa aatttcccaa cattaagtgt cagcaatttg

12421
gagagggaca gctgtctctt gttctctctc ttctccaatt ctcaattcct aggtctgatg

12481
ctttccctgg ctcaactgac tatggttgtg gggtagggcc atgaaacaga aatatcacat

12541
taggatccaa cctttaatta tgtagatgga cagcagttta cagaaaaagt ggtggggagg

12601
tggagggagg tgctgaacag acattctaaa agggctccac caaagaaagc tatttgttat

12661
atttatgaac attctggaaa attctttcaa ttgtgttcat gaataaatta tgattggtta

12721
aaagctaaca cacatgtaga ttatataact tctaaaattt gtatttggta tctgaatcta

12781
tatattattt tggcatgtat agaaaaatcc cagatatttc aaaggctatc attagaaaaa

12841
cgttaatgaa aaggttaatg gaattctata tatttagttc ctgtgagaat gtccagttta

12901
actttcttaa tcaactgatg aagaaacaga actgaaatca caagattata aagatatttt

12961
aacgatgcat ttaggttttc attctaaatg ctgaaaaaag gtatccctgc aaatactggt

13021
taagaaatta agaagtccaa aacccaataa tgtagttggc agcctgttat aaagatttag

13081
agtattcaaa gataaaggca aataaaaaga ctacttttta taccagagta gaaacagttt

13141
attttcatga tcactactct tacttcaaat atatctatta tctaagttga tgcttgcaaa

13201
aagtcctgat tcttacacaa aggcagtcga ttcatggatc tcttagagag agagaaaaaa

13261
aaaaagctag ttgggtgtgt tacagttata tgaatcatgt aggatgctgc ttaacgctat

13321
atttatcatg gatgaaggca tgttttcagg ggaaactatg agtctaccta aagttaccca

13381
gttcacctct gttccaaggg actcatcttt tcagcatttt gtttagcatg ttacaaagta

13441
ccccgatgtc ttctaaacta ttaggattgc aggaggaaac tctcccagag ctgctagaag

13501
tcatccttga aagtttggat ttctcccgaa aacttgtatt tctatcattg ttttaactat

13561
cttcttgaat cctcttgatc ctgacctaca tgtcctcttc ccttgattgc atttaaattt

13621
agctgcatat aaccttgctc ttttccttct aatccaacct ataaaccata tcaggggagg

13681
atatgtgatt tgtcaatttt gttgcctcac ttcctcctca agaactttca gtggctccat

13741
tttacctctg agattaaatt gcagccactc atcctgagtt ttggtgttcc acaatctgac

13801
atatctagtc agctttgtgt tctagtgtgt ttgtgttgct ataaaggaag actgagacta

13861
gatagtttaa taagaaaaga ggttgatttg gctcacaatt ctgcttgctg gaagattggg

13921
catttggtaa aagccttagg ctgcttctat tcatggcaga agagtaagcg gagccttcat

13981
gtgtggaaat catagggcaa gggaggcagc aagggaggtg tggagaggtg ccaggctctt

14041
tttaacaacc acttctcatg ggaactaata cagtgagaac tcactgactc tttctacagg

14101
gagggcatta atttattcgt gaatgattct cccccatgac caaaatacct ctcattaggc

14161
cccacctcca acattgggat aaaatttcaa catgaggttt gaagggggga caaacatcca

14221
aactatagca ttctgctttg gccccctaaa acttatgtcc ttctcacatt caaatacaat

14281
catttcttcc taatagtccc taaaagtctt aacttgttcc agcataaact caaaagtcca

14341
aagtccaaag tatcacctgc gactcaaggc aacttcttta cagctgtgag cttgcaaaaa

14401
taaaaaatga attatattct tccatgatac aatggttgta caggcattga gtaaacattc

14461
ccatttccct aagggagaaa ctggccaaaa gaaagtggta acaggtccca tccaagtctg

14521
aaacccagtg cggcagacat tctttttttt gaggcagagt ctcgctccgt cacccaggct

14581
ggagtgcagt ggtgcgatct cggctcactg caagctctgc ctcctgggat cacgccattc

14641
tcctgcctca gcctcctgag tagcbgggac tacaggcagc tgccaccatg cctggctaat

14701
tttttgtatt tttagtagag acggggtttc actgtgttag ccaggatggt cttgatctcc

14761
tgacctcgtg atccgcctgc ctcagcctcc caaagtgctg ggattacaga cgtgagccac

14821
cgcgcctggc cagacattaa ttcttaaaac tccaaaataa tttcctttga ttccatatac

14881
cacatcctgg gcatagtagt gtgaggggtg ggtcctaagg ccttaggcag ccccactctt

14941
tggctttgct gggtgcagcc cacgtgactg ctctcacaga ttgaagccca atgcctgtgc

15001
ctttttcagg ctgcagttgt atgttgctgg tggctctata attctggggt ctggagggtg

15061
gtagccctgc tcccacacct ccaatagata atgcccaagt agaggctgtg tgtggttgat

15121
ctgaccctat ggcagacttc tgcctgcctt cccaggtgtt ccaataaatc ctctgaaatc

15181
taggtggaag ctgccaagcc tccaacattc ttgcattatg ggcacctgca gatttcacac

15241
catgaagcca ccaaggctta ccacttacac ccacctaagc agtggctcaa acagtacctg

15301
gggccattgg agccatggat ggagccagag tggccaggat gcagacagca gcatcctgag

15361
gcagcacagg gcagtggtac cccaggcttg tcctgcaaaa ttattttgtc ctcctaggcc

15421
tctaggcttg tgatgggagg agcagcctca aaggtttctg aaatgccttt ggggcctttt

15481
ttttccaaag tcttggctat tagaacctag ctcccactta gtcatgctaa tatctctcta

15541
gcaagtgttt ggctgcatcc ttgaattcct ctcctgaaaa cactctttct tcatctacca

15601
cagggccagg ctgtaaatct tccaaatttt tatgctttac ttggttttta gttacaattt

15661
acaactttag gtcactcatt tgctgccata tctagtttac aatcatattt acaattaaaa

15721
gcagtgtaaa ccaaaaagta tctgagacag gtctcaatca atgtaagggt ttattttgcg

15781
atggttaagg accatggccc atgacacagc ctcaggaagt cctgagaaca tgtgcccaag

15841
gtagttttgt gtagcttggt tttatacatt ttagggagac agaagttaca gacaaaaaca

15901
taaatcaata catgcaaggt atacattggt ttggcccaga aaggcaagac atctacaagt

15961
gggggcttcc aggtcatagg tatattcaaa aatttcctga ttggcaatgg ttgaatgagt

16021
taagctctgc ctgaacagtt gaagtcagct tgagttaaga taaagaggtt ggctgggcac

16081
tgtggctcat gcctgtaatc ctagcacttt taggaggctg aggtggtcag attgccacct

16141
gggcaatctg tttgagatca gcctgggcaa catgatgaga ccctgtcttt ccaaaaaata

16201
aaaaaattag atgggcatgg tggagcacac ctgtagtcct tgctactcga gagactgggg

16261
caggaggatt acttgagccc aggaggcaga ggttgcagtg agctgagatt gcaccattgc

16321
attccagcct gggtgacaga gccagaccct gtctgaaaaa aaaaaaaaaa aaagtgaaag

16381
tcaaggttct tgtcatgtgg atgaagcctc caggtagcag gcttcagagt gaatagatga

16441
tgaatgtctc ttattagaac ttaaaaggtg tcagactctc tggaaaaaac ttggtaaggg

16501
agagattctc tacagaacac taacttcctc cacaagagac aacattgcag ggccttttca

16561
aaatgtcaaa taaatatatt ttgggataaa atacttgtat tgtattgtat tgtattgtat

16621
tgtattgtat tgtattgtat tgtatcgtat ttttgagaca gagccttgct ctgtcatcca

16681
ggctggagtg cagtggcacg atctcggctc actgtaacct ccgtctcccc agctcaagcg

16741
attctcctgc atcagcctcc tatgtagctg ggattacagg tgtccaccac catgcctggc

16801
taattttttt gtatttttag tagagatggg gtttcaccat gttggccagg ctggtcttga

16861
actcttgacc tcaagtgatc tgcctgcctt ggcctcccaa agtgctggga ttactgggat

16921
tacaggcatg agccaccaca cctggacaat aaaatacttt tatttccttt aggtcttgct

16981
atgtcatgtg atgctatatc agagtcgggt tcaaatttgg tatcttattg ctacaaagag

17041
tctgtcttgt cagtcatatg atctctgttt taatgttaat gctggtcatt tgtgtctaaa

17101
ctccaaaggg ggagggtgta ataaggcatg ttgggtaccc tctcatcttg ctatggcatg

17161
agctagtttt tcaggtttct ttgggatctc cttgaccaag gggtccattc agttgattgg

17221
gggagtttga attttaattt tgatttccag cagccacgcc acttcttgaa tgctgtgttg

17281
cttagaaatt tcttctgctg ctgggcatgg tgactcatgc ctgtgagagg caggcacttt

17341
ggaaggctga ggtgggcaga tcaattgggc tcaggagttt gagaccagcc tgggcaacat

17401
ggcaaaaccc catctctaca aaaaatacaa aaaaaaaaca acaacaaaaa aacaaatcag

17461
ccaggtgtgg tggcatgtgc ttgtagtccc agttactcgg gaggctgagg tgggagaatg

17521
acctcagcct aggagatgga ggtttcaatg atcctagatc gtgccactgc attccagcct

17581
gagtgacaga gcaagatcct gtctcaaaaa caaaacaaaa caaaacaaaa tttccgccag

17641
atatcctagg tcatcactct taactgcagc cttccacaaa tccatagggc atggacacaa

17701
cacagccaag tttttttttc taaagcataa catggaaccc tttgctctag ttcccagtaa

17761
gtttctcatt tccttctgag acctgctcag ccttgccttt actatctata tttctatcag

17821
cattttggtc aaaaccactt aactaatctc taagaagttc caaactttcc ctcatctgcc

17881
tgtcttcttc tgagccctcc aggttcttcc aacctctgtc caatgccctg ttccaaagtt

17941
gcttccacat tttcagttgt ctttacagca acatttcact acttggtacc agtattctga

18001
ctttgtccat tttgcattgc tttaaacgaa taccggagga tgggtcattt acaaagaaag

18061
gggtttattt ggctcacagt tctgcaagcc tgtacaagaa gcatggtgcc aggatttgct

18121
tttggtgaag gcaaggaagc ttccattcat ggcagaaagt gaaggggagc ctccatgtgc

18181
agagatcaca tggcgagaga ggaagagcgt gagaggaggg gaaggtacca tggtcttttt

18241
aacagaggta caggcttttg agggaactaa cagattgaga actcgctcac tcccacccct

18301
gccagggagg tcattaatct attcatgagg gatccaccca cataacacac acatctcact

18361
aggccccacc tccaacattg ggatcaaatt tcaacatgaa gtttgggagg gcgaacatcc

18421
aaagtacagc accttgtttc ttgttgtttt ctaatatttg ttctttatcc caggaaatgg

18481
ggggtaggaa ggtgagttct tggtgtactc taagcagtca tgctcagcct gtactatcaa

18541
attttattcc atttattctt ctgttgaggc ttgcatgact tccctaaggt acaatggcag

18601
agatagccac atgggtagta aaatcagggg cagacagacc agctttctgc caggaattta

18661
cctcagggaa attcctcatc tttgactttc ctcgttctga cttttttttc ttttaattcc

18721
acctcctctc caaacctggc actattcctt tccgatcttt atccttgtcc ttactgtttt

18781
gaagttggct cttatgcctg tttgtctttg caatctgtct ctgcgtcgcg tgttggtagt

18841
catttatttt tgtccctagt catgattccc agaaccttgc tgtggtcatt ttgatgcccc

18901
accctttgac tattacaaac caggagagct catgcaagtg gccacatgct gtagtggtta

18961
agagcacagg ccccgtagct gaacttgaaa ctcagcatga caacatgctg gctgtgtgac

19021
taaggcaaat taaatgacca ctctgtgtcc ttattttctt atacataaaa tggagctaca

19081
atagtacctc ctcataggga tgttgtgaag cttcagtgag ttaatacaga tataatgatt

19141
agttatctgc ctccattaaa tccaatcatc aatactaccc agctttatta aaacttctga

19201
cttttgtttt ggatgtggcc aggtcctgaa ctgaattgtt ttttccaggt caaatttaaa

19261
tctaccctcc tttccttttt ctcaatgcca aattgttctt cagtttccat ctctagcccc

19321
ataatctttg atttctcttg cccacatgga tggttacctt ttctgaaatg tcatagctct

19381
tacagtgcta gccacctatt ttgatgccaa atctttacac caaccagtgt tatcacttaa

19441
tcaattctta catctatgtc ttaacttctc caaccaaact taagacttgt tggtgccaag

19501
aatcaaatct catacttttg agttattcaa accatacaga acagtagata ctgaataagt

19561
atttgtctga atgaattgtt tgaataactt aaagagccta gaagcggctg ggtgcgatgg

19621
ctcatgccta taatccgagc actttgggag gctgaggcgg gccgatcacc tgaggtcagg

19681
agttcgagac cagcctgaca aatatgatga aaccccgtct gtactaaaaa tacaaaaatt

19741
agccgggcat ggtggcatgc acctgtaatc ccagctactc aggaggctga gacaggagaa

19801
tctcttgaac ccaggaggtg gaggttgcag tgagccaaga tcacaccatt gcactccagc

19861
ctgggcaata aaagcaaaac tccatctcaa aaaaaaaaaa agagcctaga agctttccag

19921
ggtggtcttg ggggtattgg ctttagaaga ggaagcttga tagatgaaaa tttccagatc

19981
aacggcattt tatgtacttc tcagaaacaa ggtatgacta gactgaaaga tctgaagtca

20041
ggaagaaact tcttggtatc agtctgtgcc cttaggaaga agtgaggtca taagctctat

20101
tagcacacat agctgaaaaa ctgaaagagg atgtaagaga aaggattgtt aaaaaacaaa

20161
aacaaaaaaa cacaaaaaac caaaaataaa aaatctgggt gaggtatttg caatactaga

20221
gccaaagaat ttgacctaag aggccgggcg tggtggttca catctgtaat cccagtactt

20281
tgggaggccg aggtgggtgg atcacttgag gccagaagtt tgaaactaac ctggccaact

20341
tgttgaaacc ccatgtctac taaatacaca caaaaaaggg cccggcgcgg tggctcgtgc

20401
ctgtaattcc agtactttgg gaggctgagg tgggaggatc acctgaggtc aggagatgga

20461
gaccatcctg gctaacatgg tgaaaccccg tctctgctaa aaatacacaa attagccggg

20521
tgtggtggca tgtgcctgaa gtcccagcta cttggagggt gaggcaggag aatcacttca

20581
acctaggagg tggaggttgc agtgagctga ggtagcgcca ctgcactcca gcctgggcga

20641
cagagcaaga ctctgtctca aaataaacaa ttaactgggt gtggtggcac acacctgtaa

20701
tctcagctgc tcctgagcct gaggtgggag aatcacttga acccgggagg cagaggttgc

20761
agtgagctga cattgtgcca ctgcgctcca gcctaggggg gagaaaaaga aaaaaaagaa

20821
ttctgatcca ggcactgact cattgagcaa gtcatcttta ctgttcaggc ctcagctttc

20881
ttcctttgtt tttttttgag acagagtctc attctattgc ccaggctgga gtgcaatggc

20941
atgatttcag ctcactgcaa cctctgccgc ccgggttcaa gcaattcttc tgcctcagcc

21001
tcccgagtag gtgggattac aggtgcctgc caccgcgccc agctaatttt tgtactttta

21061
gtagagatgg gggtttcact atcttggcca ggcbggtctc gaactcctga cctcatgatc

21121
cacccacctt ggcctcccaa agtgctggga ttacagatat gagccaccgc acccagctag

21181
gcctcagttt tctaatgtgt aaaatgaaaa tatgcactag accttcactt gtttttttct

21241
atgtgataat tttttttaaa aaaagaaggt gtcatgttac attttatctt tatgtttaca

21301
tttcatcttg taaggttgcc tttgagcctt gacacagtga tttttctcat tcaactagtt

21361
tctctcccat ctcaactagt gacctcacca tccactaatt gtttaagcca gaaattggga

21421
acttttcctt ggttcctctt ccttgtttac ttcttccatc taccccatga gcaaatccta

21481
tctgttcttc cttaaattta gttcccagat ctatctcctg catctcaggt ctatgtactt

21541
cttcccatct cccctgctac tagtctgtcc agagctacaa ccacttccct tatagattat

21601
tggaataacc ttcttattgg tcttcatatt ttcactctga ctcccctctg atcaattttc

21661
tgcaatgcag ccagaattat cttttaaaaa tgtaagtttg agccaggcac agtggctcac

21721
gcctgtaatc ccagcacttt gggaggccaa ggtgggagga tcacctgagg tcaggagttt

21781
gagatcagcc tggccaacat ggtgaaactc tgtctctact aaaaatacaa aaattagctg

21841
ggcatggtgg tgggtgcctg taatcccagc tacttgggag gctgaggcag aactgcttga

21901
acctgggagg ccatatatat ataaagtttg atcacaccac tgtcctgctt aatctttttt

21961
tattttttaa cttttaaatt ttttaagaga agggtctctc tgtgttgccc agactggtct

22021
ctaattcgtg ggctcaagag atcctctcat cttagcctcc caagtagctg ggaatacagg

22081
catgtgccac cacacccagt gactttcctt cctaaaatgc ttcaatagtt tctttttctt

22141
tttctttctt tctttttttt tttttttttg agatggagtc tcgttctttc acccaggctg

22201
gagtgcagtg gcgtgatctt ggctcactgc aacctctgcc tcccgggtta aagtgattct

22261
tctgcctcag tcttccaagt agcbgggact acagcatgtg ccaccacacc tcaataattt

22321
tttgtatttt tagtagaaat gggtttcacc atgttggtca ggcbggtctc gaacagctga

22381
gcttgtgatc cacccgcctc ggcctcccaa agtgctggga ttacaggtgt gagccactgc

22441
acccagccac ttcaatagtt tctttttgtg cttaacataa agtttaaatt catgtccaga

22501
gcctataagg tgtcatatga ccaggcccct caaggtatat ccacttcact caagccatgt

22561
ttgtctcatc ttaattcttc aaacacccca cattctttcc taactcaagg tctttgagct

22621
tgctgcttct tccaggtgga ctgatcttag cccttccctt tgttgttgat tttttaactt

22681
tttttttttt ttttttgtga gaaagtcttg ctcttgtttt ccaggctgga gtgcagtggt

22741
gcaatctcgg ctcactgcaa cctccacctc ctgggttcaa gtgagtctcc tgactcagcg

22801
tcctgagtaa ctgggattac aggcacctgc caccacaccc ggctaatttt tgtattttta

22861
gtagaaatgg ggttttgccg tgttggccag gctgatcttg aactcctgac ctcaggtgat

22921
cctcccacct cggcctccca aagtgctggg attacaggca tgagccagcg ctcccagcct

22981
ttttaccttt ttttttttta atttcaatag gtttttgggg aacaggtagt ttttggttac

23041
gtgaaaagtt ctttagttgt gatttctgag attttagcac acccatcacc tgagcagcgt

23101
acactctacc caatgtgtag ctttttatcc ttcacccccc caagtctttc cctgagttcc

23161
caaagttcat tgtatcattc ttatgccttt gcattctcgt agcttagctc ccacttacga

23221
gtgagaacat acaatatttg gttttccatt cctgagtctc caattccacc caggttgctg

23281
tgaatgccat taatatgttc ctttttatgg ctgagtagta tttcatgata tatatataca

23341
cacacacaca cacacacaca catatataca cacacacatt tatatgtgta tatatacaca

23401
tatatatata tgtcacattt ctttatccac tcattgattg atgggcattt gtagccctgc

23461
cctttgaatg gctgacttct tcttatgctt cagaattaat actttgtaat tacattaata

23521
tgtttttttt aaaaaaaaac cttttacata tatattggtc tgtcacaata atgtataaca

23581
atattatagt ttctgtttta atgacttaac tttggcaaac tggtcaatga tttcattaaa

23641
actgatcttt ttaaaaataa tcagcttcaa tagacagttt aaccagattt gtcaactttt

23701
tgtttttggc acagtctcac tctgttgccc aggatggagt gcagtggtgc catcttggct

23761
cactgcaacc tctgcctcct gggttcaagt gattctcatg cctcagcctc ccgagtagct

23821
gggattagag gcacctgcca ccatgcccag ctaagttttg aatttttagt agagataggg

23881
tttcaccatg ttcgccaggc tggtctcgaa tgcctgacct caagtgatct ggctccctcg

23941
aactcccaga gtgctgggat tacaggcgtg agccaccaca cccggtctcc ataaaaaaat

24001
cttaaacaaa aggatatggt tggtgaaata caaatcctat tgcgcagtaa ttttcacaaa

24061
ttttaaaatt gacaatacct tcgcttcttt cagatcaatt atagtggctt tcaaatgtca

24121
tcgctcaaaa aagttcaaat gtcatcgctc aaaaaaaaaa caaaccttca ctagaaaatt

24181
aatcataaat tgatggtaca gactgggtgc agtggctcac aactgtaatc ccaccacttt

24241
gggaggccga ggtggatgga tcacctgagg tcaggagttc aagaccagca tggccaacat

24301
ggtgacaccc cagctctact aaaaaaaaaa aaaaatgaaa aaattagccc ggcgtggtgg

24361
tgcatgtctg taatcccagc tacttgagag gctgagacag gagaatcgct tgaatgcaga

24421
aggcggaggt tgcagtgagt cgagatcata acactgtaat ccagcctggg caacagaggg

24481
agactcctca aaaaatataa aaataaataa attgatgtta catttggaaa aactgctgaa

24541
attttcttct tctgcaaaaa gttagaaaaa accactgaat gattgaaaac attgacatta

24601
tttaattctt tgctttagag caagtactca gttcttgatt gaagtgattg agggattcaa

24661
acattgtcct tttgttttct tccggtaacg tcagaccagc atattttgtt attgctgctg

24721
gctgttttct tcaaaatttg ctttgaaaaa gatgtaaatg gccatttcct tatacttgtg

24781
attaaatatt tgttggcctt tccaccagtt ctctgcactg atcttcaaga aaaaatttta

24841
aaacctgcac acaaaatttt aaagactgaa cacagaattt taaagcatgc acatttttca

24901
aagcbgtttc tatctctttg gaagtttgtg tctgattaag ttcatctaag acttcactcc

24961
aggaaaaaag ttaacccaga aaagataaat agcctcagca gagagaaaaa tctactgatt

25021
ttcttgtgtc tacattttgt tttagatagc ataatacttc aaaagttggt actcatttct

25081
taaactttac tgtgtgcata gcttcaaaat gaatactttg ttgtgtgtgg gaaagccttt

25141
tcattgttat acttacaatc ttcagcatgg tccatccgtg aatctttttt aaaattgata

25201
aaaaggccag gcgcgatggc tcatgcccgt aatcccagca ccttgggagg ccaaggcaag

25261
tggatcacct gaggtcagga gtttgagacc agcctggcca acatggtgaa acctcgtctc

25321
tactgaaaat acaaaaatca gcbgggtgcg ttggcgtgcg cctgtaatcc cagctactca

25381
ggaggatgag gcaggagagt ggtttaaacc tgggaggcgg aggttgcagt gagccgagat

25441
tgtgtcactg cactccagcc tgggcaacag agcgagactc cttctcaaaa aaaaaaaaaa

25501
aaatggttaa aaagatgaaa taaaaatttt ccaagttccc ctcaaccccc ctaaaaaaaa

25561
atcatacatg aagaaacatt tccaaaacag tggagtttgg agattgattt gcacaagcac

25621
aaatgaggat ttaggataaa tttctttgac ttttacctga acactacagt cagtcttggc

25681
catagtttca gcattgccat gtccttggtc atgatagagg ttcatgtcca gcatatcaca

25741
attcagtcat atggtgacta ttatgtgagt tcaggagtgt ttatcctaga aatagaaaga

25801
cacccaggaa tgactccttt ctttcaaatt tgctgttctc aaaatgaaca tacttaagga

25861
ctttacattt gatcagggta taaaccactg ggaagactaa gtgctcagaa aaagaaccaa

25921
agacttggag ataggaacag agcctgaaat gaacagaaac tattctatac cccccatgaa

25981
cctagaaaca aatgtgtata gctaagcgta ttagtccact cgggatgctt taacagaata

26041
tcaataaact ggaatgcttc acagtaaaca tttatttctc acagttctgg aggctgggaa

26101
gtccaagatc tggtatctgc tgaggttcct cttactggtt tgcagatggc cgtcttcttg

26161
ttctatcctc acatggcaga gagcagagaa cagaccatct cttgtgtctg ttcttagaag

26221
aacattaatc ctatttatga gcactctacc ttcgcaacca aaaggcttca tctccaaata

26281
ccatcacttg gagatttagc cttcaacaca ggaattttgg gggtacacaa acattcaatc

26341
catagcactg agtctgtatg tgttgggaac tgattgataa attggaattc ttcaaattaa

26401
cttacatgta gaatacagta tttattaaag gataagtaaa aagaaatgtg ttaatttata

26461
gtgtatttat tattattaaa agtctatagg gcbgggcaca gtggctcatg cctgtaatcc

26521
cagcactttg ggaggccaag gtggggtgga tcacgaggcc aggagtttca agatcagcct

26581
ggccaagatg gtaaaattcc atctctacta aaaatacaaa aattaattgg gcatggtcag

26641
gcgcacgcct gtaatcccag ctacttggga ggctgaggca ggagaactgc ttcaatgaac

26701
ccgggaggtt cattcaagat cacgccactg cacttcagcc tgggtgacag agtgagactc

26761
tgtcttaaaa aaaaaaaaaa aaaagtctac agtaactgca attgtttaga atttaagcca

26821
acaagatatg ttttcttttc cgggagttgt attttttatc actgattgtc tacaattgac

26881
agtgcatgtc aaaaagcaga cttgtcgtgc tgcagtggct cacgcctgta atcccagaac

26941
tttgagaggg cgaggcagga ggattgcttg agcccaggag ttggagacca acctgggcaa

27001
catagtgaga tcccatctct aaaaaaataa aaataaaacc actcattttt gtcaatttta

27061
ttactgcttt taatttttct aaagacgatg tgctgctcca gctctgggta cacacatgcc

27121
cacgagagca agctcatgag agaagaaact acatcccctc tatccaccta tatttctaac

27181
gccttgcaca gtagctggca catagtggac atgaaataaa tatttgtgga ataaataagt

27241
gaagaagaat tttagaatac tttataagaa acaataaatc ttcagagatc aacatttcaa

27301
attagtaact ttatttacaa acctctcttc tgggttttat tatttactac aagtgcttgc

27361
aagacctgtt attgtacact catgtattcc tatcaaaggt aatcatcaga cattatattt

27421
cattaaataa tttaatggtg ctttctgttc tttattcatt aatttttttg tgtgtgtgtg

27481
agaatggagt ttcactatgt tgcccaggct ggccttgaac tccagggttc aagtggatcc

27541
tcctgccttg gcctcccaaa gtgctgggat tacaggcatg aaccaccatg tccaacaatg

27601
ttttctgctc tttagtaagt ctagccatat taaattttat gtgttttttt tttctttttt

27661
gagactgagt ctcactctgt cacccaggct ggagtgcatt ggcgcgatct ccactcagtg

27721
caacctccgc ctcccagttt caagcaattc tcttacttca gcctcctgag tagctaggat

27781
tacaggcacg taccaccaca tctggctatt tttttttttt ttttttttga gacgaagtct

27841
cactctgttg cccgagctgg attgcagtgg catgatcttg gctcactgca acctccacct

27901
cctgggttca agtgattctc ctgcctcagc ctcctgagta gcbgggacta caggcatgtg

27961
ccaccatgcc cggctgattt ttgtatattt tttaacagag atggggtttc attatgttgg

28021
ccaggttggt ctcgaactcc tgacctcgtg atccacccac cttggcctcc cgaagtgctg

28081
ggattacaga tgtgagccac cgagcccggc ctaatttttg tgtttttggt ggagatgggg

28141
ttttaccatg ttggccaggc tggtctcgag ctccggacct caggccatcc acctacctcg

28201
gcttcccaaa gtgctaggat tacaggcgtg agccactgtg cccagctcat attacatttt

28261
aaatggaggt agaatatcaa cctgaattca ctaagagaat gcaggacaaa ttgccctgat

28321
atcctgacac aaaggtgaag caggactttt ttgtaatttg aggatttaaa agcatggttg

28381
ctccaggcca ggcgtggtgg ctcctgcctg taatcccagc actttgggaa gccgaggcag

28441
gcggatcatt tgaggtcagg agttggagac cagcctggcc aaaatggtga aaccctgtct

28501
ctactaaaaa tacaaaaatt agcbgggcgt ggtcaggcgc ctgtaatccc agctacttgg

28561
gaggctgagg caggagaatt gcttcaagga acccaggaag cagaggttgc agagcccata

28621
tcgtgccact gcactctagc ctaggtgaca gagcgagacc agcctggcca acatggtaaa

28681
accccgtttc tactaaaaat acaaaaaatt agcagggcaa gctggcgggc gcctgtaatc

28741
ccagctacac gggaggctga ggcaggagaa tggcgtgaac ccaggaggcg gagcttgcag

28801
tgagctgaga tggcgccact gcactccagc ctgggcgaca gagggagact ccatctcaaa

28861
aaaaaaaaaa aaaaaaaaag tatggttgtt ccagtcctgg gaaattgaaa tagggggtaa

28921
aaaggctggt gggtgtggta ggcagaataa ttacttcttc cctctcccaa gatgttcagg

28981
tcctattccc catcctattc cctggaacct atagctagat tgccttatgg ggcaaaagga

29041
atttttcaag tgtgactaaa tttagaatca tgagttagag agattatcct ggattatctg

29101
tgtgggttta atgtaatcac aggggtccct agaaagaaaa gagggaagca gaaaagccaa

29161
aggagatgga atgatgggag ttgagatcag tcagatttac agatgcaata ttgtttccta

29221
taaattctgt ggtgaaagaa atgctatatt gttgctggct ttgaagatgg aggaaggggc

29281
tgagagtgaa ggaatgcaag tgaccttaaa ttggaaaaga caagaaaata attggccctg

29341
tagaggttat aaaagaaggg tggtccttct gacacactga ttttagtccg atgagattga

29401
ttttgaactt ctgacttcca aaaactgtaa gacaatacat tagtgttatt gtaaaccact

29461
acatttttgg taatttgtta cagcaatagg aaacttatat agtgggccct gggatccatc

29521
tgccctagcc gtttatctaa aacaaaagat cttataggga aagcaaacaa acaaacaaaa

29581
aatacagaaa caaagcaaaa caaagcaccc ctatgctctg agcttgggcc tggtaagggc

29641
actatgagcc catgatttag catgttgctg ggaaatctcc ttccccctgt tgagttgcca

29701
gaatcgtgga agcagatggt gtgggggatt caggctcctc cactgctttt ctcagccaga

29761
cctttgagga gagcttggct gaagtcttcc aagctttatc cccttgtagc cattgttttg

29821
agccatctca aacattaagt agctcttgag ggttgaattg agtccttcct aaagacagac

29881
taaagtccta gtctccagga cctgtaaatg ttcccttatt tgtaattagg atgtttacag

29941
atgtaatcaa attaaaatga ggtcataccg gactagggtg ggctctgatc caatatggcc

30001
ggcatcctca taagaagagg agaagagaca tagacacata gggaaaagac cgtgtgatga

30061
tggcagagat tagagtgatg tgtttacaag ccaaggaatg tcaaatattg ccggcaatat

30121
cagaaactaa gaaaaaggca tggcacagat tgtctctgag agcctctcag agagtatggc

30181
cctgctgaca ccttagtttc agaggtctag catccagaac tctgagagaa cagatttgtg

30241
ttgttttaag acacccacca tgtggtaatt tattacagta gcccttaaac taacacagtg

30301
accttgtgtc ttctgccaga gggatttgat cacactggtg aggaagggtc ctggtccata

30361
ataacccaaa tttctgccag ggaagaggag attgaaaggt cccagtgatc ttggcctatt

30421
tacttgggag ctcttccaca gaacaaatga actcctgaag atgagctgct acaaggattc

30481
tgtgctttgg acagaattgc acttgtctct tccccctgct gtcactccct gactaggaaa

30541
ggtccaagct gtgaaggaat cccccccaga agagacttgt aagcattaaa gacctgtgga

30601
aaactaagag ggagggtgga tagaggagtc tggagaccga ctaaccttct gagctgctta

30661
ttgcctgaag tgggggtgga gtgggctgca aacactgttg tatttggggg acacatcaca

30721
gatgcttatt tgcaccttgg actttgtcag gacactctgg ttacagcaca actttgtgaa

30781
catggatcac aagatacttg gaaaagcagt gtttgcatta atcagattag gattagctaa

30841
aattttaatt aaagaaccag agagtacttc agaggcaagg agatgatagt tacctgggat

30901
tacttgctat ttgtgaaacc aaccagctga ccacttgtgt tgtttgtccc aaggtataat

30961
aataactaga tgtttgcata ttgtgattgt ttctgttcgg atttaatggc tgatctattt

31021
atcatattaa aagagggatc aagttcaaag atttcaatgc tctttatctt ctttctatat

31081
atgatattta tttttaaatg tccatattaa atatacatat atacacacga ttctcagaat

31141
tacgaagaat gtgcbgtgta gcattcaatt atatatataa tttttttttt gagatggagt

31201
ttccctcttg ttgcccaggc tggagtgcaa cggcatgatc tcgggtcaca gcaacctctg

31261
cctcccaggt tcaagtgatt ctcctacctc agcctcctga gtagcbggga ttacaggcat

31321
gtgccaccat gcbgggctaa ttttgtattt ttagtagaga cggggtttct ccatgttggt

31381
caggctggtc tcgaactccc aacctcaggt gatccaccgg cctctgcttc acaaagtgct

31441
gggattatag gcgtgagtca ccaagcctgg ctccaattct gtatattttt aaatgtaagt

31501
ataaagatca aagatacaaa gtatattcac atatcagttt ccatgttgtt attattatta

31561
ttatttgcca ttttaaccat ctccagatga agaaaactga atgtaaagtt aaatatctcc

31621
ttaactttta ctctatttaa aaagagactg aattatttgt gaggtaaccc agttgtagct

31681
gttctactct tctctactgc tagattttgg aagaaccaaa aaggaataaa gcaaagcatg

31741
acacagaaga gaaagcagaa ttatactgta gtagtatgct catattttat cagagtttgc

31801
ctgtactttt gctgattttt ttttctccta gcttggacat tttaaaggct tattttaaat

31861
ttatctcttc tgtattaaca ggtgagaagt ggacaaatca atgtataaaa actactatgg

31921
ctatcatcat ttagaatttt gtcttaaaag taattggatt tctggggtcc tagacacata

31981
atgattagag atcatgccac cagttctata tggagccatc tcaattcatc ctttctcaat

32041
ttatcctttc caggcatttt tcttgaaact gcctaagtac tggcgtctcc ctacgactat

32101
tatatctgaa aacacattca gttttcaaac cagctgaatt ttatgcctga ctattccttt

32161
taacttatac caatgaaaat cctttaataa attcactcac aattgctcca ctttctcaaa

32221
cagagcacaa agcatctaac aatatttctt catgattgat agcatacaca ctcttgactt

32281
catattcttc aaaatcttgg tatttttata agcattagtg cctttttttt ccccagtcag

32341
aagcactgac ggatttattc tattgggtgt tgtcttctgt ttggtcttta gcttttctta

32401
gctgtgatcg tttattgctg aataattaag ggcaattctt tcccactgaa atacttttca

32461
agttaaacat tttttcctta aatttttgcc ccaggctact tctagatcca gcgttgttcc

32521
agcttactga gcattccaga gggctaaggt ccaagttagc caaggtttta aaatgttgac

32581
catgtggacc tgaattcttt ccagttacat atttgcatac ttttaacagg agtggttatt

32641
tctcgtcaaa agacagaacg ctggaaatac cagggcaaaa ctatgtgttt ttttcttggt

32701
gatatcttga tcttagcatt ttactctctc ttcctggttt ctagcttgac ctttgtattt

32761
tagaggagag taatagagta acagtgcact gagaagcaat gggacatgac agaatagttt

32821
cagcagtgaa agtcagggaa gctggtttca accattcatt cacaagctta aaggactttg

32881
gtatctgact ttgtggatgc cactttctca tctgtaaaat aagggggttg gatcgtgtga

32941
tttataaggg gctttcttac tttctaacat tccatattct ataaagacag ttaaagtctc

33001
cagagagtaa agaatgtaga aaattcctga aatttactca gctcctttat tcctaaatat

33061
ttttgaattc tgaaattatt attattatta ttttttgaga tggagtctca ctctgctgcc

33121
caggccaaag tgcgatggca caatctcagc tcactgcaat ctctgctgcc caggttcaag

33181
tgattctcct gcctcagtct tctgagtagc tgggattaca ggcatgtgcc accatgcctg

33241
gctaactttt gtattttcag tagagaaggg gtttcaccat gttggacagg gtagtatcaa

33301
atttctgacc tcaagtgatc cacccgcctc ggcctcccaa agtgctggag ttacagccaa

33361
agcacctgac ctgaattctg agttttgatt ctgttttttt tttttttttt ttgagacaga

33421
gttttgctct tgtcacccag gctggagtgc aattgcacgt tctccgctca cagcaacctc

33481
catctcccgg gttcaagtga ttctcctgcc tcagcctccc aagtagatgg gactaccacc

33541
gtgcctagct aataattttg tgtattttag tagagatggg atttcactgt gttagccagg

33601
atggtcttga tctcttgacc tcgtgaccct ccctccttgg cctcccaaag tgctgggatt

33661
acaggcgtga gatactgcgc ccggcccata ctcacagatt tctttgtgat attatctcat

33721
ttgttttcac cacacccaga tgatgtggat ggtaggagaa atcccatgcg aataagtgga

33781
atatgttagt aactgcttcc ttgggtcctt ttgcctctgg acttaactct ttttttttga

33841
gacggagtct tgctctgtca cccatgctgg agtgcagtgg cgcaatcttg gctcactgca

33901
acctctgcct cccagattca agcaattctc ctgcctcagc ctcccgagta gctgggatta

33961
caggcatgtg ctgccacgcc tggctaattt ttttgtattt ttagtagaga tggggtttca

34021
ccatattccc caggctggtc tcaaactcct gaccttgtga tccacccacc ttgaccaccc

34081
aaagtgctgg gattagaggc atgagccact gcacctggcc tggacttaac tcttaaatga

34141
tgttacccag gaaaaccaat ctatgactaa ggcaaaaaaa aaaaaaaaaa aaaaaaaaaa

34201
aaaagttgca cagagaagag tggaaatatc agtaaatcag aagctaggca ggcctaatcc

34261
ctaatccact tggtgacctt ctgcaaaaca cctttctgtt agccttttca cccgtgaatt

34321
tttttttttt tttgagacgg agtttcgctt tggttagcca gactggagta caatggtgcg

34381
atctcagctc actgcaacct tcgccttctg ggttcaaggg attctcctgc ctcagcctcc

34441
tgagtagctg ggattacagg aacctgccat cacacccaga taatttttgt atttttagta

34501
gagatggggt ttcaccgtgt tggccaggct ggtcttgaac tcctgacctc aggtgatcca

34561
ccttcctcgg ctgcccaaag tgctgggatt acaggcgtga gtcactgtgc ctggcttact

34621
tgtgaaatta aagcttcaac ttttactcct taggaacgtc tcacaaattt ccacacataa

34681
atctaaagta gacactcctg cttgccaaaa gcatactctc taaaacattg gttctcagac

34741
ggacatagtg gctcatgcct gtaatcccag cactttggga ggccgagacg ggtggatcac

34801
ttgagatcag gagtttgaaa ccagcatggc caacatcgtg aaaccccatt tctactgaaa

34861
atacaaaaaa aattagccag gtatggtggt gcgtgcctgt aatcccagct actcgggagg

34921
ccgaagcagg agaatcactt gaacctggga ggcggaggtt gcagtgagcc agatcccgcc

34981
actgcactct agcctgggag atagagcgag actctgtctt ggaaacaaac aaacaaacaa

35041
acaaacaaaa aaattggttc ttgagcaggg caatttcacc tccaagggga catttgacaa

35101
tggcbgggga catttttggt tgtcacatct ggggttgggg agtgaagtgc tattggcatc

35161
taatacgtag aggccaggga tgctgctgaa catcctgcag tgcacaggac agcccctgac

35221
agcattaaac agtccaaaat gtcaattgtt ttttgaggtt gagaaacgct ggtctaaaag

35281
aaatgacagg acaggtggct tggctcatgc ctatcatccc agcactttgg gaggctgagg

35341
cgagtggatc acctgaggcc agtagcttga gaccagcctg gccaacatgg tgaaacctct

35401
tctctactaa aaatacaaac aatagccggg cgtggtggcc cacacctgta atcccagcta

35461
ttcagaaggc caaggcagga gaatcgcttg aacccggggg gcaaagattg cagtgagcta

35521
agatcatgcc actgcactcc agcctgggtg acagagtgag actctcaaaa aaacaaacaa

35581
acaaaaaaac agaaatgact caaatgttta cagtgattac ttctggatgg gattatgata

35641
attgtttctc tactgttcta aaaaactttc tgttctttcc aaatgtttaa tattgagcac

35701
ttattttaca atcattaaac aaagaaatga caacaactgt taaaaaaaaa ttcttaagaa

35761
ctgaaaggca aacaccacca ccactaaagc catgtccccc agatctaggt tgtgagtcac

35821
atgataccga cttcagaggc agcatgtctc aaggcctctc caatgtgtgt cagggacagc

35881
agtgggagta gggccctctg agtcagcctc tttgacctgg gatgctgcag gagatcttag

35941
caaacattca agattttcac tgagtcattt gcctgtggca ttgatctgct cactcaagtc

36001
ttccggtgtt ttggtgtgag ggaggctaaa gaggaaaaac agcbgtttag tttctcattg

36061
atttgtattg tcattgagca atacctggag cccaagtgga tgtcttttat tctgtggcct

36121
ccacagctgg gtcagtgtgg aaggcttcag accatgagaa attgttcctg ggagtcaatt

36181
attttaataa gtgagatatc agagtatatt cacagaaaga ggcttccctg gcactgtaag

36241
ggcagccagg aataaaataa aaatgcttct tcagtgaaga taattgtcca aattgaagac

36301
ataggaaata tttctaattt gcctgtgtat ttggtgaaca tttctctctc tctctctctt

36361
tctctctttc tctctctctc tctctttctg tctccataaa tgaagacatg ggaaaatcta

36421
ttaaaaatta aattaaaatg caacactttt acataaacaa aattcccaat cactctcctt

36481
actttacctc agcccaacca aatgtgagtt aaatctcttc cctttcccat gggacactag

36541
catcttggtg gcccagctca gtagctaagc atagagtaat gagtttgtta aataatttca

36601
attacattgt ttttgagatt ccagggtcac agggaaattc tgacctgaat tatctggatg

36661
aactctcaca attgtgcact gccttgttca aatttgggaa gtgctgagaa gcactcatcc

36721
aaggggtaga tctggacttc agctcatgca gcataataga atttcaggct cagtgatttc

36781
taatctgtta ccacttgcca ttttctactt gaagagggca gacaccttca ctgatctctg

36841
tttctatttc atcttttgaa aaatcgggat gataatggtt atctggttta catgctttta

36901
catgcttgtc aggagttatt ttaaagcact ttacaaatat aaaaatgtac aataaaattg

36961
cagagtcgga tgcagcaacc cctgtatcct ttgaggaatc tatcacaatt catacccctc

37021
ccaagccaac ttttctggta ctactctgga aaattgtgct tatacagtta aaatttttat

37081
tttcaaaaag ttgtgtaatt ccctttttca accatttttt tttgttataa gaaatgcaat

37141
taaaaacata cttttctttc caaatagaag agcctattct gccttataag aattgtttga

37201
aagattgaag gacaaatgaa gtcatacaac ttctctgata ccatattgaa ctcaaatgaa

37261
cacattttga ggtaagaaat gagcctggaa gatttttctt tttttttttt ttgagatgga

37321
gtcttgcttc gtcgcccagg ctggagtgca atggcgcaat cttggctcac tgcaacctcc

37381
gcctcctggg ttcaagtgat tctcctgcct cagcctcctg agtagcbggg attacaggag

37441
tgctccacca ggcctcacta attttttgta tttttagtac agatgggttt tcaccatgtt

37501
ggccaggttg gtctcagact cctgacctca tgatccaccc gccttggctt cccaaagtgc

37561
tgggattaca ggcgtgagcc actgtgcctg gcaagagata gaatttttca caaaaataac

37621
tcataccaga aactttgtag gcccccaccg atgcccataa tctttaggaa acaaactcta

37681
gtgtcaccta tttcctgata ccttctgtaa cgaccaggtc atattctgag ttcctacagc

37741
actcagtgtt tctcatcgga gctgtagcaa tggagtaata aatggcactg ctcaggaaga

37801
gagaattcag aaagaaaaga gcagggccta gaaaaggaac aaacttatcg gatgtgtaga

37861
gaaagaatct gcaaagcaag taataaaatc cagaaaaacg tggtatcatg gtggtcacaa

37921
aaaaaagagt ggttaaattt tcgaaaatgg agacaaacca ctcaccatga tcgtgccatc

37981
tgaatagaaa cacagaaatg atgacaaaaa aatggctaaa gaaagaaggt caacaaccat

38041
gtccaatgct ttggatatta agaagtgttc agatggattt agcaagtaga aagtcactga

38101
cacttggtgc acaaccagac ctcaatgtat ttaggaggaa actgttattt tggaacaatt

38161
gaaagctttc atttggctga gaaatatcaa ctcattctta aataggtatg ttagaaggag

38221
cctctgggcc tgatatctcc ttgattacaa ggaaaatgaa taatagttgc gtctgataac

38281
catgacatat cacccctatg tttgcttgta gctttcagca gctcagaaca ttgttgaaaa

38341
cactcattat cccaatatcc ccaacaggga agtgttaaaa cctgccttgt gcaactgtca

38401
atctctgatg attagataaa aacaattatg tcatgagttg tagctattgt tatttacttc

38461
ccaagagcca gattacacag gtatctgatt gctgaagcaa tgtctggatg taccacgaaa

38521
ttccacatgc atgtacagta taaacacctc tggctatcac cttatctaat tttgatcaga

38581
tacaggttaa tcccctcctg tatctttata tgtcctgaat ttgcctcatc cacctgaact

38641
ttgccataat ttactctcaa tttgtatgtg tctgtgatgg agttgttgtc attttccttt

38701
tctttttctt ttttttgagg ccaagtctct ttctgtcacc cagactggag tgcaatgacg

38761
cgatctcagc tcactgcaac ctctgcctcc cgggttcaag taattcccct gcctcagcct

38821
cctaaatagc tgggactaca ggtgcatgcc accatgcctg gctaactttt tgtattttta

38881
gtagagacgg ggttttaccg tgttagccag gatggtctct tgatccgccc gcctccgcct

38941
cccaaagtgc tgggattaca ggcatgagcc accgcgcccg gcctcatttt ctctatctgt

39001
ctgcttaatc aggttttgca agtttcacat ttcctcaact aaacttcatt ttaccaccca

39061
agcaaacttc attataatta ttttattttt ctgatgacat cagatttctg taggggtacc

39121
tattagctag agatacttag attttatttt cccagcatgt gactatttcc cattctatac

39181
aacacaatgg caagagcagg agtatgtttt tggacaatta aagagagaaa aggccgggcg

39241
cggtggccca tgcctgtaat cccagcactt tgggaggctg aggtgggcag atcatgaggt

39301
caggagatca ggagattgag accatcctgg ctaacacggt gaaaccccat ctctactaaa

39361
aatgcaaaaa attagccggg cgtggtggtg ggcacctgta gtcccagcta ctctggaggg

39421
tgaggcagaa tggcgtgaac ccgggaggca cagcttgcag tgagccgaga tcgtgccact

39481
gcactccagc ctgggcggca gagcgagact ccgtctcaaa aaaaaaaaaa aaaaaaaaaa

39541
gagagagaga aaataactca gcttcattta gatttctatt attcttctct gatccatata

39601
gtggatgttc acagaagtgt aggaaccaaa actatgcaag ttaaactgtt aattttagaa

39661
gtttatagca gtgatgtgga aggctgacca aagttggcgc tttggtctca ctataagcca

39721
tagtaataaa tacattaaca atgtccacaa acaacagtag acaccattta gtaagggctt

39781
gctccaagcc aggcactgtt ttcagcttaa gtctcacagc cttgtgaagt agattctgtc

39841
ccatcttaga gcaagttggt ctgaggatcc tcaagggtaa ggtctcttgc caaaggtcag

39901
cagaggtagt gagttcagaa ctgggattta aatccaggct gttctatttc tattccacaa

39961
ttctgcctca actgcttctc tacattttag gcacacgttt gaatactgaa aatttgggtc

40021
acagagttgg agatgtttct tcttctaggc cccaaaccgg agcggggtgc agtggctcaa

40081
gcctgtaatc cgcactactt gggaagctga ggcgggagga tcgcttgagc tcaggagttt

40141
gaagatacag tcagctatga tcctgccact gcactctagc ctgggcaaca gaacaagatc

40201
ctatctctaa aaaaaaaaaa aaattaaaat tttaacacaa gggcccaaac aagtcaacag

40261
taattacaac atgatcttta ctactgtcta ataacatctc acagtgcttt aaacatacgt

40321
agttaccatt ctgtccactt ggttgcctgt aatattaact cagtaagtag gaatacttcc

40381
tgccctgact aatatactca taaatatatg ctctaagtca agggtcttgc aggttctgat

40441
ttaaaaaaca caattttttt gagggtcact ggctttacat tatctcattc ttttcaagtt

40501
cctttgtacg taaaacatcc tatgctcagt tatatgatct gttcaacctc ctgcttgaca

40561
gatatgaaaa cagtgctctc atgtaattta tgtaatttac atttttacat atttagcagt

40621
acacctttgt gctatgttat attgtttgag aactaatctg tttttctgat ggctggaagt

40681
ctaagtgaaa agattataca tgaaaataat tcatgtttat tatcactagg agaaagtaag

40741
acaatttagt ttgattcaca agcatttgaa tccctattgt gtcagacatt gtattggaaa

40801
ctggggatac aaggaagata taacctcatc tctcagagtt ccctagttat cccatacata

40861
tatacaatta ttatttgtca attaaatttt ttttaaaaat ttagaaagga gtttccaagt

40921
aagaaaaatc atagcgaaat ggtataattg gtataataac agttaattag ctatagtatg

40981
aaaatacaga ggaagatcta actaagttgg ggattattaa agaaaattta aattagctgg

41041
gtgtggcggc agacgcctgt aaccccagct acttgggagg ctgaggcagg agaattgctt

41101
gaactcaggt ggtggaggtt gcagtgagat gagatcactg ggtaacagaa caagactccg

41161
tctcaaataa aataaaataa aaaataaaga aaattggaca gagatgtggc atttgaactg

41221
tctttcagat taagaagaaa gttactagtt agccaattca aatataagat ttacaaacat

41281
agagtacagc atgagcaaag gtgtggaggt acaaaaagaa taatgttttt gaggggagaa

41341
tagcaagtac tctgggggtg gccaaagttt gagttgtgtg gttttggtgg tggatggaga

41401
tgcaggaaga ttaggaagta gattgagatc agattgagaa aggtcttcca gaccagatga

41461
aaaattttgc catatttagg caatagggag ccccagaaat tgttcaacca tcatcagctt

41521
tacatttcac tatggtaatt tggcttcata agaagcatgg gttggagatt gataagagca

41581
gactccaagg ggccaattca ttaaactcaa ctgccaataa tgcaagagac aatgaaagcc

41641
agaatgaaca cagtgaccat ggatgccaga ggcatttcta ggatttttgt agaggactta

41701
agagaccatt tgggagggga ggaaggcaga agataagggg aaagaaggag ttgatatctt

41761
tgatgactga tggcactttt gctaagatga agaataaatg gtagcaagaa taaattgact

41821
gggcgcagtg gctcatgcct gtaatccaac cattttggga ggctgagatg ggtggatcac

41881
ctgaggccag gagctcgaga ccagcctggc caacatggtg aaaccccatc tctactaaaa

41941
ataaaaaaaa ttagcbgggc atggtggcgg gtgcctgtaa tcccagctat tcgggaggct

42001
gaggcaggag aatcgcttga acctcgaagg tggaggctgc agtgaacgag atcaagttat

42061
tgcattccag cctggacaac aggagcaaaa ctctggctca aaaaaaaaaa aaaaaaaaaa

42121
aaagtataaa ttgggggagg ggaggagata taggattcct attggaatgt attgagtttg

42181
agattccagc ctggacatat ggcactcttg aattgtttcc taggcgatca tatcactgtc

42241
ttgatgatat ctttaatcac acatatcact tgtggggaaa gaagaaactt caagagtttt

42301
acacaccaat cctttacttt gccatctaga caaattatat ttttaccaat gccatttttt

42361
gttgttattt tgtgggttct gcttaaaact tcccctatat ttttctaatt atggtaacct

42421
agggaaaaca tcaaattatg ttgataaaat tggctacaat ctggctctaa tgataatagc

42481
ttagaatcat gaagcagcaa tattttatcc tgagagcaaa caaactttat cctgaacaca

42541
tgtgttcttt tgccttattc atctaatatt acttgaaact tttatttttc cactttgaat

42601
agtagattct gccaagtgtt ttaaaagctt ttctcttttt aggggaggag gggaacagct

42661
tttctccctt ttgtctgata actgaggagt gaagatttaa ttggtgagaa aaatatacac

42721
actataaacc tcagaatgtt cccactgctt ttaatgtttg atgtgcctga cagattaccc

42781
tttcaaaaca gataatagga taggtggtgc tggaaaaaaa cttttccatc caagacaaaa

42841
ccacatggac attgaaaaga actggcattt gcctagacat ttagtggggg acatgtcctt

42901
agggcacaga ttccatagtg aaaggctctt ctcccccttc cacacactcc agctctctct

42961
agaaggtata atggaaagaa ctctgagcaa gaatcaggaa gttggccttt gttcctgact

43021
gtgccacttt gtggaactgg gcagaactta cctcattctg tgctttagca gcttcatttg

43081
caaaaattaa tgattacctc aaatgatttc tgattttagc caaaattaaa tacagtagtt

43141
ttaaaacaac tgctacatat taactactta cgtatgtaat tttgcactca aaataaatta

43201
tattatggaa aagaaactca acctatgtta accatccctg tactgatgag gaaactaaga

43261
cttaggaaaa agaagtgatt tactcagtat tgggcagtta gtgagcattt ttgagccaag

43321
gtcttacttt aaccagagac ctttgcataa tattgtactg ttactaaaca ctttctatta

43381
tttgactaga ggaacacaac atattgatgc atttgaaaca ataaaataat aaatattttt

43441
ccttaccctc ggcagaaaca ggatgatgag aaacattgac taaaaattta atcaagcctt

43501
aaggacaaat agtatcacag ttttgaatag gagattgggt accttggaag taattatgaa

43561
gaggtgtttt aactcagcag taggctcttt cttattcctg ctaggaatga agaagcacaa

43621
attgaaagtg aagaaggagg aaataaaaca ctgactctat gtgtaagaaa ggtgacttgc

43681
aaattatgag gcagttagga aaatgtttat tttttcttat tttataggct gtatatattt

43741
gagaattaat aattgtcctt tggagggtgt gtgtgtatgt gtatgttgga gctttgtgtg

43801
tgttttagtc cattttccta ctgctatgtg aagaaatgcc cgagacggta atttataaag

43861
aaaaagaggt ttaacggact caccgttcca catggctgtg gaggcctcac aatcatggtg

43921
gaaggtgaag gaggagcaaa ggcacatctt acatggtggc aggcaagagc gtgtgtgcag

43981
gggaattgcc ctttataaaa ccatcggatc tcacgagact tattcactat cacaaggaca

44041
gcatgggaaa aacttatccc catgattcaa ttacctccca ccagctcccc tcaagacaca

44101
tggggattat gggagctaca attcaagatg agatttgggt ggggacacag ccaaactgta

44161
tcagtatgcc tgtgtgtatg catgtgcacg tatataaatt ttttcactag tgactgatgg

44221
accatctata aaataaacaa aagagaagag acagggtctc actttgcctc ctaggctgga

44281
atacaatggc atgaccatag ctcattgcag cctctaattc ctgggctcaa gtgatcctcc

44341
cttctgagta gcbgggatta caggcacgtg ccattatgcc caactaatgt tttgtttgtt

44401
tgttgtggag atgggagatg ggagtactgc tatgttactc aggctggtct tgaactcact

44461
cctggcctta agtgatcctc tggctttagc atcctaaacc actacaatct taaaaaggac

44521
cagtttcctg gattacctct ctccctccat catccactat ctgccgtcaa ctctatagag

44581
tcaagggcta tccctgcctt ttcaatagaa gccctcaaga agtcactcca tagggactat

44641
cttgggcttt gggaagtgta cagggttggg gtgggtggga aggtgaggag gaaaggccac

44701
tgtttcaggt ggggttggag ggagatggaa aatggaccac agaggttcag agaacaggcc

44761
ctttgtggaa agggggagac caaataatgc tgcgttgtga aaggtgaaac aggctgcaaa

44821
cagaaggagc ccacaggaag ccctgctctg agcagctgaa cattctgggg tcctcagact

44881
ccgataaaaa agcacattta gcctacagct ttatgccctt cctcctaccc ttgtggactc

44941
tgccacagac atgccctcca gattgattct atccacttgt ctctagtcta ctgctactat

45001
tttagtctaa ggccttctcc ccgctttcct gggttatggt cacagactcc tatctgagtt

45061
cccagcacca ggtgcccagt tgttttcatc tcttaacaca ttccacatat tatagcaaga

45121
gagatctttc tcaaatgcaa atcagacctt gttgcatccc aatctcaacc cctttagttg

45181
ctcttctctt tgccctcatg gtcaagttca agctctctag tgtgggggca gatgttcctt

45241
tataattttt ctgcttatgt ctcctgcctc aggcctcaca attctccacc tcacagatga

45301
tgtctcagcc atgatgagtt cctctcaaat cctttaggtt tcagagatgt catttcccct

45361
gggaacattt tcctgactcc tcgttccaag catatgtctg tctttatgtt cccatagcac

45421
ctgatcattg gatcatggta gggtttatca cggtctcgta tttgtctgct tacttgtctg

45481
tattcttcac ttctcaaata tgtcttcttt gttcatcact gtaactcctt tccccagaat

45541
gttctcagat atttacaccc atcttccccc tctgtgaagg gaataaatgg atatataaca

45601
ctgtattagt ccattctcat gccactatga agaaatatcc aagactgggt aatttataaa

45661
gaaaagaggt ttaaatgatt acagttctgc atggttgggg agaactcagg aaacttacaa

45721
ttatggcaga ggcacctctt cacggggtgg cgggagagag aataagtgca agtaggagaa

45781
atgccagatg cttctaaaac tatcagatct catgagactc actcactatc acaagaacag

45841
cacgggggaa accgcccccc atgatccgat tgcctctacc tggttccacc ctagacatgg

45901
tgattatggg aattaaaatc caaggtgaaa ttttggtggg gatacagagc caaaccatat

45961
taagcaccat cctcaaaata gccttccagc tgaagacagc taaggcactc atgtagtctt

46021
attttgtctc agacaaataa ttttaccttt gaatcattgt tcattaatct agattttaac

46081
ctgaggccct aaaaattgtt tatcatcttc tgggagatct tactcctaga tggtgtttta

46141
ttccacaggt taaatttaaa cttgggccaa atctccatcc ttgtggcctg tgagtactga

46201
atttgggact gaaagcctgg gactaactgg aagtgtggaa aaggaggagg gtgtggcgct

46261
gccctcaatg attttttttt ttttttagga tttctggtgg aaaaggagag acactcagga

46321
atccccagat aaacatggtt tagcttttgt agtcagatcc tttccccaaa tttactgctt

46381
ctttctccac cacttctcaa ccccccaaac tgaacttgcc tcttcaacac actcccttgt

46441
gccctataga cagtcacaag cttgacctat agagagcatg tatttcttga ggcaacgaag

46501
gtaggaaacc ctattctaaa atgtttctta cacttttggc tctgtctaaa ttctccattt

46561
ttcaattaaa atggaaacga gattagaatt ctattctagt tatgaatata atcagaacac

46621
aataaagcag aaagattgct tcaggctctt ctgttaacgt tacatttatt caacaactct

46681
ttatggggac ttgctatgag tgaggcacca ggctaggcac cgcagctaca aaggtgaaga

46741
gaacataggc tcttcttcaa agaaacttac actgtaagct ttatagttat gaaatcatga

46801
ttgcttacct taaatgttct tgacctacat tcttagatat tttgagtctt gagaaatttg

46861
tttatttttt tcattattat acaatgtcaa ttagctcagt ggaatccaag atgttcggct

46921
agccttctga tccaagatag tggaccaaac atttgtattt actcattgtg cccctccata

46981
cttctctgaa ataaaagtgt agatcttcaa aattaaacat atctataaag caaagggaac

47041
agaaggggac attatcagca gattagacat tccaaaaatt ttttagaaaa taaaagctaa

47101
attgaatagt aagacacgga attattagat gtgtttggaa aaccaacagc atgaacaaga

47161
taatccaaga aaaacaagtt gtcccttggt gaaaatggaa ggaatttgag aaatatagaa

47221
gtgaactaaa caataaatac agtcatccct tggtatctgt tggggactga ttccaggacc

47281
tccctcagat accaaaattt ggatgcccaa gtctctgata taaaatggta cagtatttgc

47341
atacagccta tgcacatcct actgtatact ttaaatcatc tttagattac ttataatacc

47401
taatacaatg taaatgcttt gtaaatactt gttatattgt attgtttagg gaataatgag

47461
aggaaaaaaa gtctgttcat gttcagtaca gatgcaactt tttttttttc cagaatcttt

47521
ttaacctatg gttggttgga atccacaaat gtagaacccg gctacagaga gctgactgta

47581
attaaaacca acagcttcta tttggtatac tgaaagagaa ttgggaaatc attaaatcca

47641
taaaataaga acaggatgga gtgaaaaaag ctggactctg tgacgaaatg gacatatgta

47701
tggataagaa tcaggaaagt tttcataaag gaagtgccaa actgagctag ttggccaaat

47761
gaactattct ccaggtggat ggggcagggc atttaggcag aggaagcaac aaagcacaga

47821
gtgaagccca ggaaactaca ggtagctgca gggagatgac ggggctacag tgtgcatgga

47881
gagaggccaa catggtgagg taggcaggag gagctcctga agggctccaa cctgggaagc

47941
caggctaaag agatggcatt ctatcttgtc agtaataaga agcattgaca ttttgtagag

48001
atgatgaatt gaggaaggga tttatgtggt catttgtggt tctggctgat ccccctgagt

48061
gctgtctgct agaaggattc caagggttaa gtcctgaggc gtgaagaaga accgatctgt

48121
aagatagctt aactaaggtg gtagcattgg gataagggtg tggggtgtgt gtgtgagggg

48181
gatacaaagt tattaaggtg gtagaattga tggcaacatt catcttgaca gagaatacag

48241
gatgaggagc agatttcaga ggaatataat gagccctttt ttagatcttt gtgaatgttc

48301
agaaatggca gcbggtgttg cataattgca aaattagggc ttagttagtt attggcttct

48361
gagaacgtaa ctgcagtttt tttctttccc tctgccccac tctttgaaag ggggtggggc

48421
tcaaagagta gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtggtaaa tacttatata

48481
caaatttctt tagatttttc tttatctcct tcactccttt tcaacatttt ggctggttgt

48541
tctgatatta ccaaggtaat ccacaattat ggcaaatatt caaacaaaac aaattataga

48601
aagtccagaa aaaaaaactc tgaaatacct tttccagaga ccaccatcat gaacagtttg

48661
gtctacagaa ttacaaatct tttgaagtat atagtatatt cttttatgtg gccattcatt

48721
atattttatg ggatcttagt attattgctt ttaaattcat ttcttatatt ttaaatttga

48781
aatacttcaa aatatgcaga aaagtagaga aaataacatt aacaccatat acttaccatg

48841
tagatttaag agaaatctac actttgccaa atttcctttt tttttttttt tttttttttt

48901
ttttttgaga cagagtcttg ctctgtcacc caggctggag tgcagtggtg cgatctcggc

48961
ttactgcaac ctctgcctct tgggttcaag caattctcct gcctcagcct cctgagtagc

49021
tgggattaca ggtactcacc accatgcttg gctaattttt gtatttttag tagagatggg

49081
gttttgccat gttggccagg ctggtctcga actcctgacc tcaaatgatc cacctgcctc

49141
ggcctcccaa agtgctggga ttacaggcat gagccaccgc acccgaccaa atctccattt

49201
ttgtaaataa tttttcagat atagaaaact acccaattat ggcbgggcat ggtggctcat

49261
ggctataatc ccagcacatt gggaggccaa ggcaggcgga tcatttgagg tcaggagttc

49321
gagaccagcc tggccaacat ggtgaaatcc cgcctctaca aaaaatataa aaattagccg

49381
ggcatggtgg caggtgcctg tagtcccagc tacttgggag gctgagggag gaaaatcact

49441
tgaacctggg aggcggaggt tgcagtgagc tgagatagca ccattgcact ccagactggg

49501
tgacagaaca agactctgtc tcaaaaaaaa gaaaagaaaa gtaagaaaac tacctgatta

49561
ctattacttc tctctttctc tctctctctc tgtgttctag aggtttgcag tatcctgaag

49621
ctggtgtgaa tcaacctcac gctttttttt tttttctttt tttttgaggt ggagtctcgc

49681
tctgtcgccc aggctggagt gcaatggtgc aatcttggct cactgcacct ccacctcctg

49741
ggttcaagtg attctcctgc ctcagcctcc cgagtggctg tgattacagg catacaccgc

49801
catgcccagc taattttttg tatttttagt aaagatgggg tttcaccatg ttggccaggc

49861
tggtctacaa atgtatctat ccataagcaa taccgtatat agtaatattt ttattattct

49921
attatttcta ttgaatgttt atattcatag tatcacactg tacacatcct tttgcaattt

49981
gctttcttta gaagcaacaa tatatttttg agatttatca tgttgctttg tgtagattgc

50041
ttactttttt tttttgatgg agtttccctc ttgttgctta ggctggagtg caatggcgta

50101
atctcggctc accgcaacct ctgcctcctg gattcaagag atcctcctgc ctcagcctct

50161
tgagtagctg ggattacagg catgtactac cacactcggc taattttgta tttttagtag

50221
agatgggctt tctccatgtt ggtcaagctg gtctcgaact cccaacctca ggtgatctgc

50281
ccgcctgggc ctcccaaagt gctgggatta caggtgtgag ccactgtgct tggccaatta

50341
tttacttttt aatttatttt atgatacaca atttgtctct ttatctcact ttattttttg

50401
attttttttt ttttaaacca ggatctcact tggtcaccca ggctggagtg cagtggcgtg

50461
atctcggctc actgcatccc ctgcctccca ggtgcaagca attctcctgc cttggcctcc

50521
tgagtagcta ggactatagg gtgtaccacc acatctggtt aatttttgta ttttagtaga

50581
gatggtattt tgtcatattg gccaggctgg tcttgaactg ctggcttcga gcaatttgcc

50641
cgccttggcc tccaaactct ctttattttt tagatattgt taacggtact atgggcagta

50701
tccttgaaca tctctctttg tataaatgtg aaagacattc atagacatgg gactaaagga

50761
ggtgcccata gtcaaccatg ctaggcattg acaaatggct tcctaaaggg gtaatacctg

50821
tgtacattgc cactagcaat ttgtacactt tcttgattcc tttcactctt gtcaaaactt

50881
actctttttt aaatttaaaa ttattggcca ggccatggtg gttcatgact gtaatctccc

50941
agcactttgg gaggctgagg caggtggatc acctgaaatc aggagtttga gaccagcctg

51001
gccaaacatg gtgaaaccct gtctctacta aaagtagaaa aattaactgg gcatggtggt

51061
gggtgcttgt aataccagat actcgggagg ctgaggcagg agaatcgttt gaacctggga

51121
ggtggaggct gtggtaagcc aagatcacac cattgcactc caacacaggg gacagagtga

51181
gactctgtct caaaaataaa ataaaataaa ataattgtca atattgttgg ttatgaaatg

51241
ctatctcatt attgtttaaa gaggcatttc ccttgataac tagtgaggtt gaattttgtt

51301
ttccagatgt gcatgagcca ttggtttttt tctgttatgc attttctatt catatacttt

51361
gaccacatga tatgtgcctg gtcataaccc atcaaactct tctttctctc agatacttca

51421
ctttatggaa atctttttca cgtttatccc tcaaacccag aattttgagt gtcatacctg

51481
ttctaacata aatttgagga aaatgaaggc taattcagaa taaagaacta tataagcaga

51541
tggacagtgt gttctcctct aaataggggt gctaggataa gaggcggtag gataaatgca

51601
cagcctcaaa atccaccacc cactaaagac ctcacagtac atgatgacat tagcatgctg

51661
tgccagcatt tctacctacc acgatgacct ggaatgaagg acaaaagggg caattgttaa

51721
gtcctgtgcg taaactttgg aagagaacat accttgcttt aaaccattaa gggggcaggc

51781
aatagattcc tgtacagggt ggcttagcca aaagtggctg gtcttgttct catttatatg

51841
gtttataatg attctaaatc attctcggag aaaaacagac tcatttcatc tccctttaat

51901
taggatttct gttactgcaa tattttagtg gcatttatgt caaatgtttt cttttgagaa

51961
cttctccctt ttactgtctt ttttctttta ttttaaactt ttattttagg ttagggggta

52021
catgtgaaaa ttggttacat aggtaaactc atgtcaagag ggtttgttgt acggatgatt

52081
catcacccag ggattaagct cagtactcaa tagttatctt ttctgctcct ctccctcctc

52141
ctactttcca ccctcaagta gaccccagag tctgttgttt tcttctttgt gttcataagt

52201
tctcataatt tagctcccac ttatatgtga gaacacgcag tatatgattt tctgttcctg

52261
cgttagtttg ctgatgataa tagcctccag ctccatccat gttcctgcaa aagccatgat

52321
cttgttcctt ttaatttact ttttgctatt ctgattagag agtggccatg ctccatgctc

52381
catatggata ttctttggaa acaaagcatt tttgaaatgg taggattggg gctagtaaaa

52441
gagaacagaa agaattgtga acagggtctc ctccagtaca gatggttaaa gaacacaaat

52501
agggaagtgt gatgagtgac ctccatttaa ttgggcgccc aagctcttgg ctgctccagc

52561
atgggttgcc atcctgactg atcccttggc tcagaaacag atatggtgct atcaggaaag

52621
caaggccaat atctgaatat tgcagcagag actgctccca tttcagaaag caacccagat

52681
taaagttgat gattcagttt caataaatgc ttcctttttt ataaaaggca tttaacatca

52741
ctctttcccc tggtaatatg gaattagctt ttgggatcaa ctggaaaatg tcagagggcg

52801
attgtaaaag gccacctgct aaccacagga agcbgggctg atacagaatg ccaggttaac

52861
ttaaggtcga taatggttac ttccttgtca ctttttacat gcatccttgc tctgcagtgg

52921
gggtcataag aagtaagatg catgcaaggt gaatttctag aagtcagctt ctctgagaag

52981
tattctctga ccatacattc ctactagtcc ccacatacgc tgctgatctc cccatcttca

53041
cccccattgt tgaaattgct ccctcattgt aactgttcac tcatctgtct ccaccataaa

53101
gcttaggctc ctagaaagtc aggaccagag ctagtacagt gccccatgtt cttatggaat

53161
gattttagtg ccttgagttt ggtgtggtga ccagagctgg tggccaactg tcgtgaggcc

53221
ccagtccttc tttttgtcat gctttccctc ccagcccctc cttgaccact ctttcacctc

53281
catctttcta cttatataga gacaaataat aagatgcttg tacaaagggt gtacttgtat

53341
tatcccattt gtgttgatat tccacaacag caaattaggt ttttttgttt gtttgttttt

53401
tgatggagtc ttgctctgtt gcccaggctg gagtgcaatg cgtgatctcg gctcactgca

53461
acctctgcct cccgggttca agtgattctc ctgcctcagc ctcccgagta gctaggacta

53521
caggcaccca ccaccaagcc cggctaattt ttgtattttt agtactgacg gggtttcacc

53581
atattggcca ggcbggtctt gaactcctga cctcaggtga tctgcccgcc tcggcctccc

53641
aaagtgctgg gattacacgt gtgagccact gtgcctggcc tgataaggtt taaagattaa

53701
ataccatgtc gttaaatttg caaatctctc gaataggaaa atcaggaaca atgacaacat

53761
tcggagcttc ccagaaggta acaactatgg ggagttttgt gggcatctga gagaagcaca

53821
cacacagatg gtttgccttt cattggtcca ttcttgccca gaaggcgaca ctaactgaaa

53881
caaagaagcc tcatatgaga aggacatggg gtcacagcag cttttggggt ggccctgggt

53941
ccttgatctg gtctttctct ggctcatttt gtattgctca ctttgttact tcacaatcca

54001
gggcttgtga catttttctt ctctggagtg gaaatgacag agctgcagaa cacaagtttc

54061
tgattggttc ctatgagtca ggaaagaggg ccagttgaaa ctgggctcac acacacacac

54121
acacacaaac taggctcaca tgtgttttcc catcagctaa acaagttttc agaagtacag

54181
aaataactcg ttggggaagg ggacccagga caatgacaat gtttttgatg gtaatgtctg

54241
cagaagtaag gcaggtttcc tctgtgcctg aaaagatggc accatttgag gagatggcat

54301
actcgtggtg gaatcttcat taagatgtca aactaagctg taggaaatca actctagaaa

54361
acagctctaa tgtgagaaaa catatatcca gttttataga gcaagagctg tgatcatggt

54421
gacatttaac aactgtatta gttggccaag agggtaaaaa tatacttgac ctcttagagc

54481
accataaata ctctcagctt gtgggccaac tgtgtcatgg tcttttttct agcccctcct

54541
ctttctccct tccttcttgt ctctctcctc ctctctcttc cctccccttt ctcctttctg

54601
accctctttt ctcttctcta tcttctcgaa ccttcccttc ctcctctcct ttaggtgctc

54661
agcacctctt tgattcaata aacatttacg gagctccttc ttgtgccaac gactgtacac

54721
agagcbggga tgtcaagatg aatcagttac atttcctgcc caatgccaag ggatggcttg

54781
atgggttttg accagcccct ccctggactc ccaatttctt tttttttttt ttcttttttt

54841
tttttagacg gagtcttgct ctgttgccag gctggagtgc agtggcacga tctcggctca

54901
ctgcagtctc tgtctccctc ccaacttcaa gcgattctcc tgctcagcct ctcgagtatc

54961
tgggattgca ggcatgcgcc accacaccca gctaattttt ttgtattttt agtagagaca

55021
gggtttcacc atgttggcca gggtggtctg gatctcctga cctcgtgatc cacccgcctt

55081
ggcttcccaa agtgctggga atacagtcat gagccaccgc gcccggtgcc ctggactccc

55141
aatttctacc tcctggaacg tgctttactc accagccttg gtgttattct gcaatatggc

55201
caactgggat ttttttcaat cttacagaaa ttattctcgg aaatgtttgc tatttttttt

55261
taatgaagct acagcataca atttaaggat aaataatgta cttactctgc agctattgtt

55321
tcaagtcaaa tccgctgatt actcctccaa aattcttttc ttaataaaat ctctgaccct

55381
ttcctcttcc tgttagaact tctggagcta ccattgttcc tcctcttggg ctgctcataa

55441
cctaggggag tcacagtgaa attacttgct ttaaaattct ttaatcactc tgcgagttgt

55501
taggaaaagc tgacacatct gatttggaaa ctcccactcc agtggactgt tgtgcctcag

55561
cacacaggga cgggtggagc aaaggaacaa gaagccaaaa actctcaggg cacttactat

55621
gattgtgtaa aagagagact catcaattaa cacaggtact ggcaagtgca cttcataatg

55681
cctccatttc tagacagatc aaaaacagtg tgccctgtca ataaatgctg agtttctgta

55741
gcagcctgat tgagatcagc taacctttag gccaaaagcg ggattcttcc ttgctgaagc

55801
ttttggcaaa gcatattgag cttcatgcca gggattagat taactcttgc aaaactggtt

55861
caccaggaac aatgactcag tgtttttttt ttagtatccg gcatattgtg tggagcagct

55921
ataaatatat ttacaagctg gagtttcaag ggaggggagt aatagcttgc tgaaaaacat

55981
gccaactgag ttatgggtct tcacgcagcc agcatgctgt gttttgggct ctgcctcttg

56041
taatttttag aaattaatta gtttattctt tatttatatt tatttattta tttattttca

56101
gatgggatct tactctgttg cccaggctgg agtgcagtgg tgcgatctcg gctctctgca

56161
acctccgcct cccaggttca agtgattctc ctgcctcggc ctcctgagta gctgggattt

56221
caggtatgcc tcaccatgcc tggctgattt ttgtattttt agtagaggca gggtttcacc

56281
atgttggtca ggctggactt gaactcctga cctcaagtga tccacctaag ggtactggga

56341
ttacaggcat gaaccactgc acccggcctg ttggttgtaa ttttattttc ctcctcaagg

56401
actttgagca cattatcttc tctttaataa cttgtttcca ccctcctttg tgcacgcgcg

56461
cacgcgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtatttt ctgatctccc

56521
tacgggggca gagagtctca agcaggtatg tccatgttat taacatactg tctgcttatt

56581
aactaactgc accaatgatg aaagccaact gacaaacaag tgatgctctt atccctcctt

56641
cgcaagcaat gaatctgaaa gccaagagaa gttttccttt caacaggaag tgttttggag

56701
tccgaacaac tctgcattta gacagtgcag cttttagtta cagatcttgg caatggggca

56761
ggcagaggga gcggcaacta cagactttgc cgtaggactg ttttctatgg agtgtgtgtg

56821
ctctgacgag ctagtgacag gagggaggtt acaaaagcat ttactgaaat aaggatttct

56881
aatagaggag ctttttaaaa gtattaaata tgctaatgtg cctagggcat agtcaacaaa

56941
gagttataat acatgtcatt tttcatattt atcaaggaaa ccatgtcacc cgcagccttt

57001
ctcaatttct ggcattctga gaaacacact gtagtggtgc ctgagggtct ggggaaagaa

57061
gaatagaatg aatggggcat ctcagaatcg taaactcccc cagttgtagt tcctttcgat

57121
gttggtcgtt ggatgaattt ccagtttcta ctattgtggt tggattgggg agagtagctc

57181
aaattgggaa ttgctttttg aggatctagg gcttctggaa ttctcccagt ttctttttac

57241
ctctttatgc tatcttgtct actttgaaaa atcagtagca tccatttgat tgcagagctg

57301
aatctttcta tacagtgagg agttgtaatc acattactta taacctgctt atttaacttt

57361
ttaaaggtgc aagtcattgt aacctaagta tttactcaca ctgatcctta atatactccc

57421
ctttcttatc tgcaagcttc tttctctggt ttctcctaac tctgttactg ctcatgagtt

57481
taaaactttg tcttctcagt tcctggcttc acctgtttgg tctctgctct ccaggactct

57541
gccttggaaa tctgactcac acttctatat gtccctgggg ctcaacttcg ggcctggcgc

57601
cagaatcacc caggctccaa gcaagccttg tagactccac tcagtccttt gactcaagga

57661
aatctccact tctaaatggc tctccggttg attctgatgc cagtccaggg ttgagaacca

57721
ccgctttagc ttctagacac acagccccct cccctttttc ctggagcccc tcttgggtca

57781
tgattctatt ttccctattt ctgtactcag aagggataaa aatggaagtg tatgtgaagt

57841
tgctactacg tcccaggtgc tttaaatatg ttattttatt caatcttcac aacagtctta

57901
tgcagtctct atttttattt taagaatgag gaaaacaata cttgggtgca gtggcttatg

57961
tttgtaatcc cagcactttg ggaggccaag gtgggtagat cacttgagcc caggagttca

58021
agaccagcct gggcaacatg gcataaccct gtctctacca acaatacgaa aattagccag

58081
tctcataacc tggtctataa ataaataaat agataaaaat ttaaaaataa aataatttaa

58141
aaagaaaaga atgaggaaaa caagattcag agagccttgg tcatcttccc aaaggtgcac

58201
aattaagaaa tggctaagca ggggttctga ctcagatctg tcagcatcta cagctttgct

58261
atttaaaaga gcgtggtccg tggactagca gaatcagtgt cacctgggat cttggtagaa

58321
acacaaatac ttgagtgcca tctcagacgt actgaatcag tttcttcagg ggtagggtcc

58381
aggaatatgc attttatgaa ggcctctaaa tgtttctcaa agtttaagaa gcatggggaa

58441
ctatatcttt tcctactata tagtcttatc tctttccttg tttctttact ccaaagtatt

58501
gccttatttc tttcccagaa acctcactat cagctcactg tgcagcctta ctcatatctt

58561
cctcaaccag cagttttatt acacacaccc ttctcatttc ctcacattgc tcatggtatc

58621
tgactgagta cagggatcca acctggcttt gggttttgca ctgtcttgcc tcagtctctt

58681
aatttcttcc tatgtacatt ttaagatatt gaagacacta acttccaaac ctcttctcta

58741
aatctgacag tgaagcagtg tgtgtgtgtg tgtgtgtgtg tgcatgccag tgcatacacc

58801
acacatacaa gcacatacac agagttaagt ttggtcacat ttacttcatt aattgatata

58861
taccacaact gagaaaaact tactggcatt ctgctccaag cttgaattcc cagacgaaaa

58921
acaaacaagc aaacaaacaa ctcctcctta cacaaaaata tctagtggcc ttggaaaatt

58981
ccatttaaca ttaaattgtg tctcttcaaa gtgaagcagg gtgggcagat ttttgaacat

59041
gaatctactg ataacacaac acctcttcaa aactagaatc tcattcaggg ttaaatgatg

59101
tccaagtcaa acctgagatg ctagcatgat gccccatcct cagtcagagg tttcagggtg

59161
gcaaacaact tttgctcact ctcctctgcc tctctctata tttgcagaaa gtccagcttt

59221
cactgcaaaa gttcgataac tctgtaaaac agtttgatcc taacttcaaa agaattttta

59281
tgctatttgg aatacataaa aaatgaattt attccaatac tttagcccca taaataatgc

59341
ataatgattg gtgaaagatt agcattttgg agttcaagta cttaaagctt tcttggatgg

59401
ataatgcatc acccttaact agcataaggg gaaatagaag gttgacaagg aaaacttaat

59461
ttagggttct ttatttattt ttctctagtt atgtttacct tcccaggttg ttttattaat

59521
gccacttttc acaaggatat ttcatgaata aatatcaggt tgtatctctg gccatctgtg

59581
atgatcacgt ttttattttt aatgagttgc tcatggatta tatcctaact ggaattgcag

59641
tcagtatatt gagatgcatt gactccattt ctgtctttca ttcttctttc tcaatgtatt

59701
ctcactggat tagcactctt agccctgagg actcttgggc cagttttatt actaaaagaa

59761
gaattacagt tttgctacac agtgaccttg caagaagtat cagcacagct caatttcaaa

59821
ttctcctcaa atatcaaata tgttcttggt atattttgct tagcagttta ttgccttctc

59881
atctccactg tttttcctga gtaacagctc agaaatctat aaataaaact taataatggg

59941
gagtgactca aaagtctggt tatttttatt agtaaactat tttaggggtg aacacttcac

60001
attttacatt ctcatgctcc acagtgctga aaatagtctg aatttttttt gtgtgttagg

60061
ttgatgagaa tatttttgag atgactagca gaaaacagaa tcattaaaac agtgctatca

60121
gttttcatgt tgaataactt tacaggaaat gatagcatct ttttttcttt ttttgagacg

60181
gagtttcgct cttgttgctc aggatgaagt gcaatggcgc gatctcggct caccgcaacc

60241
tccgcctcct gggttcaagc gattcttctg cttcagcctc ccgagtagct gggattacag

60301
gcatgcgcca ccatgcctgg ctaattttgt acttttagtg gagatggggt ttctccatct

60361
tggtcaggct ggtctctaat tcccgacctc aggtgatcca cccgcctcag tctcccaaag

60421
tgctgggatt acaggcgtga gccactgtgc tcagccgata gcatcttaac aataaacatg

60481
caaagatttg taaatgttgg caaacagcaa gaaaaacata tttagaaaat tgtgctatgc

60541
tttaatgtcc tgtctgtacg ataatttact tagctcccta ccttcccccc agcccaccag

60601
aatgtttaaa ctgaaattta aagcacagtt gatcttggct tggataggca gcctgcatat

60661
taactgagga tttagttagt atccaggagc agatctactt ctcaaagtga gattcacata

60721
gcccccttgg aagctttcaa atagattgac tagcctttta aaattcctct tctccccttt

60781
cttattgccc ccgccttgtc tagctgtatg ctaacttgct gcatagaatc ctgaatttct

60841
ggatttctac atttctagct caatgaatgg ggtaaatcaa aacttaataa cactcttgat

60901
tttgaaaagc ttcagtgctt catgtaagac tttttgagaa aagatcattt tcatttattt

60961
ctgttttatt tctagcttaa tgattaaatg taagcbgttc aatacctttt tcaatatccc

61021
acttgttaaa cccacactaa acctcagaaa tattgagtca gtgatctaaa tttccattca

61081
aaatttccac aaagcagaag cataaatgtt ttcattgtca ttacaaataa acagacaggg

61141
ctgggcgcag tggttcatgc ctgtaatccc agcagtttgg gaagctgagg taggcggatc

61201
acttgaggtc aggagtttga gaccagcctg gccaacatgg tgaaacactg tctctactaa

61261
aaatacaaaa aaattagctg gattggtggt gtgtgcctgt gatcccagct actcaggagg

61321
ctgaggtagg agaatcactt gaacctggga ggcggaggtt gcaatgagct gagattgtgc

61381
cactgcactc cagcctgggt gacagagtga gacttcatct caaaaaacaa aaacaaaaac

61441
aaaaacaacc ccttcccctc cacgaaagaa aaccccaaat aaacagacaa atgaaagcaa

61501
tgaaaacagg aaaataattt tgacacctac ttctgggatg ttatgttatg ctttgcattg

61561
gttctattta ttagacatgt tcccatcttt attatttaag agcagataaa ataacctcac

61621
tacattaatc tcttttgctc tgcctctttc catatgattc ttcactagca gttcccaaaa

61681
caaaaaaatt gtgcaccaaa atcccaactg agactcaatt gtttgctgac tcaacaactc

61741
taatgagaaa tcttatacaa gagcttttgt ttcaaaagga agtgccagga aaattttgct

61801
tccctcaagc aatggcatgt tttctttttc tggacagtga gaaccatgta attaaacata

61861
ttttcctttg tgctttggct gtcaggaaac tcagagccaa acttgtagcc caagttttat

61921
ggctatgtaa gacattatgg cccatatatc tggactcttc ctttctcctt ggtattgatc

61981
ttcagtcttg gctttagttt acaaaatatg ccattataaa aaataacagt atctgtaggc

62041
tgtctgaaat tattatggaa aaagtagtgt acaaataaat gaataagtca attgtttgaa

62101
aaacaatgca tttgtatcag aaataacttt gtgagtggtc ttcaggttcc tagtctattt

62161
cattttgata tatatttctt gtgggtttac cacgtgccag acaaagatgt tcctggcagg

62221
ggggttaata atgttaacag tactcagtct ttctagtgcc ttacaggcta tagaaggaga

62281
aagaaataca aaacaaacta aaataggtat tcaattgcaa caaaagcaac ttgatgtagg

62341
ggtacagggg aaggaataat tcattctaca ggcctttaaa agataaagag gtatttcaaa

62401
ggcaaacaat ggagagaaga tcattctaag ctaaggaggt tgcatgaaga aagcataatg

62461
tcactacttt tttttttttt tttgagacag ggtctggctc tgttacccag gctgtagtgc

62521
agtgatgaga tcacaggtca ctgcaacctc caccttcagg gctcaaacca tccttccaca

62581
tcaacctccc aagtagctgg gactacagct gcatgccacc atacccagat aatttctttt

62641
attttttgtg gaaacagggt tttgccatgt tgctcaggct ggtcttgaac tcctgagctc

62701
aagtgatctg cccaccttgg cctcccaagg tgttgagatt acaggcatga gccaccgcac

62761
ccagcataat gtcatcaaat tgaagtgaga aatgggaatg tcactaccaa ccataagtaa

62821
taaacaatag attatcatta actttgctcc tagagaaaga caagtttatt tagaggtgag

62881
gcgagtagaa tttttttaag ggaacttctg ggtaatttaa caccatgatc cttctcgaat

62941
gccttacaac gtaaaaatgt agttctcctt tttcttttct tttctttttt tttttttttt

63001
ttgagacagg gtctcgcttc gttgcccagg ctggagtgca gtgacacaat cttggctcac

63061
tgcatcctcc gccgcctggg ttcaagtgat tctcctacgt cagcctcctg agtagctggg

63121
attacaggcg tgcactacca cgcctggcta atttttgaat ttttagtaga gatgaggttt

63181
tgccatgttg gccaggctgg tcttaaactc ctgacctcaa gtgatctgca cacctcgacc

63241
tcccaaagtg ctgggattac aggtgtaagc caccatgcct ggccattttt cttgataaag

63301
gggtgtcatt ggggcttctc ttactcctgt cactcatcat gggtgccatg tctttttttt

63361
ttttttttga gatggagtct tgctctgtcg cccaggctgg agtgcagtgg cgcgatcttg

63421
gctcactgca agctccacct cctgggttca cgccattctc cggccgcagc ctcctgagta

63481
gcbgggacca caggtgcctg ccaccacgcc ctgctaattt tttgtacttt tagtagagac

63541
ggggtttcag cgtgttagcc aggatggtct caatctcctg acctcgtgat ctgcccgcct

63601
cagcctccca aagtgctggg attacaggcg ggagccactg cgcctggcct gggtgccatg

63661
tcttaattga caaccacaat gaagagagga aggaaagagg aaagaataag acaatacaag

63721
aagaaaaggg aaggaaaagc caatgacaga cattaactgg attttcccac aaagagaggt

63781
catgaggatc aagagcatac agaagtttgc aaaataaaga gtttctctgg cttggagttg

63841
accaaaataa gagaaaggtg aagcgagtat aatgtacgga gacttctcct gggagaagtt

63901
gtcagtggag aagttattgg gtcatatagt gatggtgtgc agataggacc tggtggtgag

63961
ttgacgagga gccattgcca ttcagccatc aagaatcatg atgtgtgttg tgtaggaatg

64021
gagaggtgag tgtggagtgg atggggcgta gatggagaag caggaggatt cgtcatgcac

64081
cctgaggctt gccagtattg atgtcagact tcctccgacc gtgttgccac cctggactgt

64141
ttgactttgg tagctatttt aaaacagcaa gaagagctgc ttgagaagaa cctgggggag

64201
atttcacaac cagcagctgc atcgaatctc cctggatgtg tgcttttgga aacaatttac

64261
acaagggctg atttcaacat gcactaatat atacagttta gctggcattt tatatggaaa

64321
ctttaataaa atggttctaa ttagtgctta atttacatag attagagagt tctacaggcc

64381
cacacagtag ggcttgggga ttttatgtca tttgatggag atgccagttt gattcagata

64441
aagaaccaat tttagggaat actgctgaag tttgcccgac acaaatgaag gagttgtagc

64501
ttgcatttct tttacccact cttgttcagt ggcttgaact agctttctgt ctcttccaca

64561
agatttagga caagatggat ttctgtgtca gcatgtagta ggagagcttt gattttctag

64621
ttctgtcctg tgtggatctg tatgtagctc agattccccc acaatctagg tcagagaagc

64681
tgctagcctt ggtgcaaagt tttcaaaaag gcttctattc agagagatga ataaggaaaa

64741
actcacaccc tacgtgcgaa ggttgcttaa tgagaggtgt gagatggagc tcagttgcca

64801
cttatctctg tagttgggta ccgttgtgca gtctgtgcac tgcccagcca tttgcagtga

64861
ccccaaagag gatcatctgg tcatcttgcg gggagagact gtgagttcct gccatgtcac

64921
ttggtataac atgagaaaac tcaaaactct aggcagatct ttgcacctgc cctacttttc

64981
tacctgctct cacaatcttc ttgagggtga ccagagtcca agtaactaag tgtaattcaa

65041
tgtggtgaat gatatgattg ctacacagga gtatctatta aggctttcaa aatgtaaaga

65101
ggaagtgact cattcttcct ggtggtggtg gttgcatcaa ttggtgtagt ctattgcctc

65161
tctcccatca acaagggaca tttggcaaag tctggagtgt gtcaactgtg gggtggtggt

65221
actaccggca tctagtggat agaggtcagg gatgctgctg aacattttac aatgcccagg

65281
acagccctcc cacaataaat tatctggccc aaaatatcag tagtgctgcc attgagaaat

65341
ctggttatgt aacagataac tttttttttt tttttgacat ggagtttcac tcttgttgcc

65401
caggctggag tgcaatggct tgatctcgac tcactgcaac ctctgcctcc tgggttcaag

65461
tgattctcct gcctcagcct cctgagtagc tgggattaca ggcatgcgcc accacgccca

65521
gctaattttg tatttttaat agagacgagg ttttaccatg ttggccgggc tggtcttgaa

65581
ctcctgacct cagatgatcc acccacctcg gtctcccaaa gtgctgggat tacaggcatg

65641
agccactgtg cccagccaac agataacttt ttaaattctc agcbgtttaa cccaacaaat

65701
aattattttc ttcctcaagc tgtatgtcca gcatgggttg gcaacatagc cctgtttttc

65761
ctagtccctt caagaagtct attgatggaa gatgcatttt tatgtgggct tctaccacca

65821
ctatgagagg gggaaggaaa tttgttggat tgtaccctga attttaaaaa gcttctgccc

65881
agaattgaca tatattcttt ccaattgcat tttattggcc acaatccatc atatgaccat

65941
gcctgaattc agagggagta ggtggagaat acatttttaa tttttaattt tttttttttt

66001
tttgagacag agcctcactg tcttgcccag gctggagtgc agtggcgcca tctcggctca

66061
ctgcaacctt tgcttcccag gtttaagtga ttctcctgcc tcagcctcac aaatagccgg

66121
aattacaggc atgcaccccc atgcctggct aaggtttttc atatttttag tagaaatggg

66181
gtgtcaccat gttggccagg ctggtctcaa actcctggcc tcaagtgacc catcctcctc

66241
agccttccaa agtgctggga ttacaggtgt gagccattgt gcccagagag agtgcatttt

66301
tgtcttgtac ccagaaagag gagagagtga gaataatcat gaactaccct aatgactatc

66361
atgctgatgg taatggtggt tgtaggatgg tgtgagaatt taaagacggc ttcactcctg

66421
tcactttgct tacttactgc tgtataacaa actgccccaa acttcaggga tgaagctaac

66481
aaaaaaatca tttaatttgc tcatgaagtt gcaatttgga tagggctgtg tagaacagct

66541
cctctctata ccatggggca tcagttagga cagctcaaaa cctgggagta actcaaaggc

66601
tgggggctat aatcatctga atgcttgctc actcctgtgc tctcatgtca ggcagtggat

66661
gctggctgta gacagagacc tcagcbgtgg ctgtcagctt gaccacctac tcccagcctc

66721
tacatgtggc tgtttggctc ccttacagta tggtggctgg gttccaaggc agaaagtaaa

66781
tgctgccagt ttcttaaagt ctgtctgcaa attggcacag cattctttct accatattct

66841
attcatcaag gagttgtaga ggccaatttt aaggggaaga aaaatagacc ctatgtttca

66901
atagcaggaa ggtcaaagaa tgtggaggcc ccagaaaact gcttcccagg taagtgacag

66961
gatagaaaaa caagattttt tttttttttt ttgagacagg gttttgctct tgttgcccag

67021
gctggagtgc aatggcgtga tctcggctca ccacgacctc tgcctcctgg gttcaagtga

67081
ttctcctgcc tcagcctccc gagtagctgg gattacaggc atgcgccacc cagttaattt

67141
tgtactttta gtagagacag ggtttctcca tgttggtcag gcbggtcttg aactcccaac

67201
ctcaggtgat ccgcctgcct tggcttccca aagtgctggg attacaggtg tgagccacca

67261
tgccaggcca gaaaaacaag acttctttag gtggagtttg gggaatgagc tttctggaca

67321
agtaaacggc atgcatcaag gcacagaaac atcagagctg catttgaata aattctccta

67381
gctggtctta cctcctagct acttacttct actgttgaca tcaaccttat aaacttgcta

67441
gaggctcagt gtggggaaac aaacaaacaa agcctcatga aacgttttga tccaattaga

67501
aaatgtctat taaatacatt gtgtttcaca aatgtgaact attaatacaa tctgggtttg

67561
ttccgattta attgtctaaa attatacata attcatcttg ccaacaaatg aaattattga

67621
aaaattaaaa atatcaccac caattttttc tattaaatgt atatttttgt aatgatagct

67681
taagtttcat ctcagtttga gatttagtac actgtggcat tcactctggt tggggttcat

67741
ttggctctga gcttcaaggt tcaatttaga cttcaaagca tgtcggactt gacctgaggc

67801
acgtttttaa caatcaggtg cagtttgtaa ggttatgggt tgaggaatag cataaatggg

67861
ccatcctttt tctgattttg agaagagaat gactactaat acccaggtgt gttcttgtct

67921
ttcttgagtc aattctaaca gcattggctg tgggttataa aaccataaaa ttttacagcc

67981
aaaaacaact ttaaaggtcg tttagatgga acttcttcat tttgcagatg aggaaactga

68041
gaatcagaga caaagtgacc tcagggcatt acaacttact attactatat tgaaagagga

68101
agggaagctg gtgcaagttg agggacccac tgatgaactg cagggtatcc aatgttgccc

68161
ctgtgtttgg gctgagggag aagcagcttc ttagcttctg ctatgctgac ttatcttgtg

68221
atctctgtcc cagcccttgg ctgcctctcc tccttgtccc caggcctgca ccattccatc

68281
tgcctcctga ttattcactg acagctgcct tttccctcac cctttgttct cagtttttaa

68341
aaatccaatg gggagaagct tggattcaaa tgatagcatt ttcagctcat gaaaaattct

68401
ataacaagtg tatttgaccg tttgatctct ggcttctccc acacacttgc cctttatact

68461
ctgacagcca taagcttcat ttccttgaag cagattgcaa tttcaatgga aaggaaataa

68521
ttgtgtagct ttcaagctga gttcagttct aaaaaggact gagcaaagct caatcctggg

68581
ctattgtaga atcttagtca ctgaatcagg cagtgaaaga gctctctcca agcttcatgg

68641
ttatgatctt gaaaaacacc agagctaggt tcaaattcca gccataccat ttcctaactg

68701
tgtgattttg gcaaatcaca caaatactta aaattctttc gactcggttt cctcttctgt

68761
aaaatgggaa cactaattaa tgctcacctc aaaaggttgt tcattcattc aacacatatt

68821
cgttgggtgc ctcctgtgtg tcaaactgtt tcagtccagt gaggaagatg gacatgaatc

68881
caagagtcac caaaaaaatg taaagtggca cctgtgatga gtcacaaagg ggaggtatat

68941
gagaaagtgt gtgacagtat ctaacaggtg agggcattat ataatttatt gttgcaaaca

69001
ggacattttt gagcatgtaa gagggtgtgt taattgtcct ggaacaacag gcataaatca

69061
ggactttctg ggcaaactca ggccctaccc cactcttacc tacccttagt ataagaggga

69121
aggttgggaa aggctttcct ggggaaggga agaagaaact gagatccgcg gaataagtga

69181
ggattcctag gcaaaaagag gaagacagag tggtttaggc caagagagca aacagtggtg

69241
caagactcta aggcaggaca aagcatggag cctgcagaga acagacagaa ggtcagtgtg

69301
atgaagatgg gaggggtgcg tggctttaaa cacaggcccc ttgcttgttg gtttgccctg

69361
taggtgttaa gaaatgaggc tatatcaagg tgaattttaa gtagaggtgg cacctctact

69421
taagaccaga cttgcagctt taaacatcag tctggctgca aggcagaatg gattagcatt

69481
gagtagtagt tctggccttg gctttccaga ggaaacttct aaacaatatc aaagccttgg

69541
tgtcacccac agagatcctg atttaattag tttaggttgg ctcccagtag gttataaagt

69601
gtgtcaggat tgagattcac tgtagaagga agtgtgaata tggagaagaa taattacaag

69661
gctattgcag tagcccgggt aagaagtgat ggaataggtt catggcagtg ggtttctgaa

69721
gcagtggttc tcaaactgta gtggatttga gtatcacctg gaagtcttat ttatttatta

69781
gagatggtct cacactgttg cgtaggctag agtgcagtgg tataatcata gctcactgca

69841
accttgatca gccttcatct cctaggctca agcaatcctg ccacttcagc ttcctgagta

69901
gcbgggacta caggcatgga ccaccatggc tatttgtttg tttgttttta atagagacag

69961
ggtctcactc tgttgcccag gcbggtctca aattcctggg ctaaagcaag cctctctcct

70021
tggcctccca aagtgctggg attatagcca ctgcaccttg gcacggaaac cttgttaaaa

70081
tgcagatatc tgggtatcat tgatttagta ggtcgtggat ggggcctgag aatttgcatt

70141
tctgacaaat tacctggagg cgctagttgc tagtttagag atcacactta gcatctagtg

70201
ggtagtggtc agggatgctg gtgaatatca tacaatacac agaacagccc ttttgctgat

70261
cactgatcga gcaaaaaaac catctgatgt ggtagataac atcaacagga tttgatcagc

70321
agggtaaagg acaactccag gactcttaca gttttctgaa tttcacaact aaatgacgag

70381
tttcactatt cattgacatt caggagacag ccctacagac ctgagaagat ggtgaagtca

70441
aagctacaca tatatttgag ggttaccttt gaaacagcta agaggataca tcaagcagga

70501
acatatatgt ggaacctgga agggaagatc attacagata taaacttggg gatcattaaa

70561
gccaggaact tatcaatggc atcagtcagt tctcttttct tttactctta tcattggtgt

70621
caaagctctg gcctcttttt gttggttcca ctcaggtgcc gtgatcctcc agcctcagca

70681
ccttgcbgtg agctctcctt gggaggctgc ctctccctcc tccttcagaa tttaccccct

70741
acttctcctt tgggtcccac ctctcaggct tggtcatgtg tggcattagc aagcaggtgt

70801
gcgtgtttcc ttctgaagca caaatcaaag ccatggttat gtatctgtgg gattatttgc

70861
taaatggcca cctctcctgc tagattctaa gttgcctgca gtgactggag aacatcccta

70921
ggtatcagat gctcaatgtc ttacacttat ggaaccgtca aagacagctg ttaaatgtcc

70981
aatgggtcag ttagggagat ggtggttgtt aaaactgtga tgagttctca ggaagaggga

71041
gaagcagtta cctttgtgaa gcagttgttg gtatttactt agtaatgaga ttaaatttcc

71101
taggacagtg ggtgtgtgaa ccagcaatag cgccatctgc tggaagtaag tgatacaaca

71161
actattatct tgactaggct cagggcbgtt aaaacagtat tgctctggga gaaaagaatc

71221
atttttttta aggttaaaaa tgtgagtaaa attctttaga gtgaagatag aatttctttt

71281
gaaatggttg gaaaaattgg ataattattg aaaatagtgt tcagttttca aagaggagag

71341
aaaccttcaa gtcactgtaa ttaagagaag ttttattgaa agaacacatg gaataaggaa

71401
gttagatatc tccacccaaa accagcattt cagaaaacag aaacaggcaa aaatctggcg

71461
gagtgtggtg gctcatgcct gcaatcccag ccctttggga ggccatggtg gaaggatcgc

71521
ttgaagccag gagtttaaga atagcctggg caacatagta agatccccat tttctttttt

71581
cttttctttt cttttctttt tttcttttct tttctgagac agagtgttgc tccttttgcc

71641
caggctggag cgcaatggca tgatctcagc tcaccacaac ctcccgggtt caagaaattc

71701
tcctgccttg gcctcctgag tagcbgggat tacaggcatg caccaccaca cctggctaat

71761
ttcgtatttt tagtagagac gtggtttctc catgttggtc aggctggtct tgaacgcccg

71821
atctcaggtg atctgcccac ctcggcctcc caaagtgctg ggattacagg catgagcccc

71881
cgtgcccagc cccaagaccc ccatttctat tttaaaaaaa aaaaagaaga agaagaagga

71941
aaagaaaaga aaaatggaaa caggcgaaaa cctaggcttc tcaaagactg aagggtattt

72001
tggaactgac tggatattgc tcatctctgg ctggttgtgt tgcagcctcg ttggtggcaa

72061
gtgcagaccc tcagtcagtg acctcctttg ttgctcttcc atcaaagggc ccccttctcc

72121
tgcccaggca tggtgttact aatatggcga tggtaggggc aggggctgca tctatgacgg

72181
ggagaggtat gagagtatac tcatcattct gctgttgtct ttgttagttt gtttctaatt

72241
tctattgttg gggagaaaga taaattcttc cctaacctct tgggatcttc acctgggtct

72301
aagaattaaa tcactgtaag acaggttaac aggagaaaaa tatatgagtt ttattgattt

72361
ttacatgtac gcggagaccc tcatgagaca gcagaagacc tgaagaaatg gacaaagcag

72421
aaagctctaa taccttttag acagagaaac cataaattca tgaagagctg acaagacaaa

72481
ggggtttggg ccagtggcag taaattgtgg gaattcacta gggaggtgta aagatagagg

72541
aagataaggg atagtttaga aagtttattt gtacagctcc attgcagcat caactcccag

72601
tcaatggtga taagagttat tttcttattc tggtacaggg agggcaactt tcttaaataa

72661
atctttttgg cttacgacag gtagaagagg gcagatcaca tagccctttc cggcatctgc

72721
tgtttctcag gtgactttag ctcaaaataa tcaacatgcc acatcagcaa attttggggt

72781
gacatggcct gtttcgctat gataatggga aagaaatcag actttttaac tttgaattag

72841
aaaacacaaa ctttgactat gtcccacaat ttatgtgact gatttcatat tctatcacat

72901
ctattttata ttctctcata ttctcctcat gaattttccc ctagaatgtt gggggaattt

72961
tgaaatgact tggggggcat gctacaattc gaaaaggaga gagacatact ctccaattct

73021
ctccctgcct gcctcacaat gtgcagctct cctctgcttc ttcttcttct tttttttttt

73081
tttgagacag cgtctcactc tgtcacccag gcttgagtgc agtggcgcaa tcttggctca

73141
ctgcaagctc cgcctcccag gttcaagtga ttcttctgcc tcagccttcc gagtaggtgg

73201
tactagaggt gtgtgccacc acgcccagct aatttttgta tttttagtag agacggggtt

73261
tctttatgtt gaccaggcta gtctcgaact cctgacctca ggtgatctgc ccacctcagc

73321
ctcccaaaat gctggaatta caggtgtgag ccaacatgcc tggcctcctc tgcttctgat

73381
tcaactgctg ctaccgatag acttactgaa ggatttgaag ccaaatggta ttaattttgg

73441
tcagttactt ccctgtatct ggtgtcctca ctagacagaa cttctgtgta tggctacttc

73501
atagaccccg accagcctac atattgtttg ctctaaggtc tagtgccctc tcttatttca

73561
ctaagataca gccactgttg gtgggggagt cacataacat ggaacataat cactgtatca

73621
gttcaggtgc tcttgattca agtggattta attatgaggg aatttattcc ttacataatt

73681
actaagtcta gcattagagt ggcctgcaga tgagggttga tccagtggct cagtgatggc

73741
cagaacgctg tttacttttt ccattctgct atctatgggg ttggcttcat cctgaggttg

73801
ttttcctttc tgtcacaggt tttacatcaa tggggtaaac tagtttacat tgtggtaaca

73861
agcaactctc aacttttttt tttttttttt tttttagact gaatcttgct ctgttgccca

73921
ggctggagtg cagtggtaca gtcttggctc actgcaactt ccgcctcctg ggctcaagtg

73981
attctcctgc ttgagcttcc tgagtagctg ggattacagg catgcaccac cacgctggct

74041
aattttcgta tttttagtag agatggggtt tctttttttt ttttttttct ttttgagaca

74101
gaatcttgct ctgtcgccca ggctggagtg cagtggcgtg atctcggctc actgcaacct

74161
ctgcctcctg ggttcaagcg attcttccgc ctcagcctcc caagtagctg ggactacagg

74221
cgcatgccac cacgcccggc taatttttgt atttttagta aagacagggt ttcaccatat

74281
tgaccaggct ggtcttgaac tcctgacctc gtgatttgcc cgcctcagcc tcccaaagtg

74341
ctgggattac aggcgtgagc caccgcgccc agccaactct caactctagt agcttaagac

74401
aacaaagatt tatttcttgc tcttactgtc tgcccatctg tatcaccttc tctgcaggac

74461
ccagtttaat ggagcacaca cagaaaaagg tgctggtcac tagggccaag ggaacaatgg

74521
ctctggaagg tttttcttga acaattcagt gttccagtct tggagcaata catcttattt

74581
ctactgttaa atccatggcc agaactaatc atgttgtccc actcaccaca aagccatatg

74641
cagccccacc atgtgctcag gaaagaggaa tgggaagcat ttgatgaaca gaaataatga

74701
cttcaacaat tgggactatc agttcacagt ttcaattgta aaaaaaaaaa aaaaaaaaaa

74761
agacagaaat agaaaaagaa caattgaaag tacttgcttt ctcatccacg aaaaaagttg

74821
gtcaaagcct cttagtgtaa gtctatagca gatgatgcct gataaggaat tgtacatacc

74881
gttcttcgtg aaaaccaaga gtaccatgta tgtaacatag ttgctttggg cttcttatag

74941
cagttaagag tgtatcagca ggcctccatg gtatttgaat gttaaaagct ttcattcccc

75001
ctggaagaaa acacatagct aactaaagaa agaaaaaaga agggaaaaag aacaaagaaa

75061
aagaaccact agagtctctg aaaagagctt atgagatacc tgactgtctg cgccttctaa

75121
gtatgtacca tgaaacctta gattcctacc tcattttgtg atggtgtaga aggcacattg

75181
gccaccagca acccttgtaa atatttgcgg atttgaattt cacaaattga aacccagact

75241
gctgagggct ttgctgctaa cgtcaaagag ctggggcaac taccacaaaa ccacatgtgg

75301
gagacttttt agatgaggag ataggaaatt cctaataaga aaagtttttt tgtaaaatac

75361
tttctaatgc tggctcttta gagaagcaca ttttacatgt gcaatggtgc aaagtcctag

75421
cactaagatt tcttcactca cagaaagaaa gaatgatgca ggtgctgttc acatgcggcc

75481
ggaaccatgc ccttgccaag caggtcagcg gggcacaggg actgcgctcc tcatgatagt

75541
gcagattggc tcggaagtac tcaattctgt ggagtcacag cgccctctga cagatttcag

75601
tttctggaaa aggaagggcc cccttcaggg tacctgctgt tcaccttcca ttagattaag

75661
gttgaagagc gagtggccat ttgtaggtac tggtatgaga tgttcctagc tacccgcatg

75721
tcagccccgg gaaacggcaa catttcccac ccttcttacc ctgggtcctg agtaggaata

75781
aaagttagtg attcttaggg gcatattgag agctggcaat gatacctctc acaaatccat

75841
cccccagaga taaggggtcc cccatgcctt tgatgtattt gggagcbgtg ctgtatgtgt

75901
tctctttggc tccccagtgg agaataataa caataacaac cgcgtactaa tacaacccag

75961
atgtcagcac agaccctctg ttctctgtct tccctgagat atctgtatct tctcagggat

76021
tactgtcggt tcaggcctgg ctcctgcttt cagcttgtgg gaaaactcac tccatcttca

76081
ttccataacc tcacatctcc tatgccagtt cccttctctg tgctccatgc tgaaccaaat

76141
gccacactca tcccctttgc tttgaattat atgaaaaaaa gaaaaaaccc tcatggggac

76201
tttatgtgta acagtcttca ctgcacattt gataacacag atgggggttt atatcctagc

76261
agagcagata ttgtcaatgg aaaatggaaa caaaacaaaa cacaaaagac aatcttcagc

76321
catcactatg tagcttggct atcatctttt gctttctcct ttacttctgg agtcccccca

76381
cataccctca gaaatggaga tagactctac atcaatctct gctctgggaa atctactcac

76441
atatccaaag gcaaactaac aagctcttgc tccgacaacc catcgacttg gggtctcatc

76501
cctccctgcc taccagtctc tgtgactgaa aggggcccat acagagactt attttcccag

76561
gaacgtgaat gatatccttc tcctgttcct tgaccttggg aggcagattt gattatggtc

76621
agctttgatt caaagtaagt tttttttttt ttctccctta ggagaatgtt gtgaggtgct

76681
gattgttctc tgcttcataa tcgtatcact tattactgat aatctttttc tgcccccaga

76741
ggttgctgaa gaatgtagca tatacagtgg acacagagcc ctgataatac aattactaaa

76801
ttctccaagg ttgagggcct ggtcttaggt catgagatta ctgatccttg ccttctgcct

76861
gctaggaagg cccaactaat ttcacagtct ttatcagtga accatagtaa agggggacca

76921
gaagagaaaa aggttatgtc ttttgggaaa atgccaaaat catattgtga aaatccttcc

76981
tactgttctt ctcatgggag ggggaggact ttggacttgt ttctctcctt ttcctgtaca

77041
tttggggatg tcagaaccgt ctgtttcctc atctacacgt ggttagatgc cgacaacaat

77101
ctcttctctt aaaattgctt actattagac cagcagagtg tttggtatta attgagcaag

77161
gaggaatttg taggaaaggc ttggcttaac taggagaggg aatgccaggg agaaatctgt

77221
atttcccact attttttttt ctttttttga ggcacagttt cactctgtcg cccaggctgg

77281
agtacagtgg tgcaatctca gctcactgca acctccgcct cctgggttca agcgattctc

77341
atgcctcagt ctcccgagta gcbgggatta caggcgtgtg ccagcacacc cagctaattt

77401
ttgtattatt agtatagatg gggttttatc atgttggcca ggccggtctc aaactcctgg

77461
cctcaggtga tctgcccacc ttggcttccc aaagtgctgg gattacaggc atgaaccacc

77521
acacctggcc atttcccact attttgttga taaagacatt tggatttccc tgcattaggc

77581
agatgtggaa gaagatggaa gcgatgaaaa ccttcttgcc aaaatctccc aaaagacctg

77641
gccagtgggt gagcagatct cagttacaaa aagcctatag gttgaatttt ctaagaaaag

77701
gcctggggag gaggtaccag gagtccaaat tgaagttcga ttttcattat cacagatttt

77761
catatctctc tatctccctt tttttgtttt tggtgagaca gagttcaaga ccagcctggt

77821
caacatggtg aaaccccgtc tttactaaaa atacaaaaaa ttagccagcc gtagaggcgg

77881
gtgcctgtca tcccagctac tcgggaggct gaggcaggaa agtcacttga acccaggaga

77941
tggaggttgc agtgagccga gatcatgcca ttgcactcca gcctgggcga caagagccaa

78001
actccatttc aaaaaaaaaa agaaagaaaa agaaaaaaga aaaaaagaaa atgcactttt

78061
tgcbgtcagt aaaagttaag caaaagtctt gctgagagac tgatatttaa ataactatta

78121
taatgcaatg taaaattact gcaagagata tgaacacagt gctcaggaag cttagaggaa

78181
ggagaaacca agtccttagt gatggaaggt gggctgtcaa ggaaggcttt gtggaggttg

78241
tgtaattgta ggatgagggc catgtagtag gtcgacgggg ccctcgtgtg ccaggtggaa

78301
ggaagccatt taagtctttt aagctgagtg gtggcatgat tacaagtgca ctttagaaaa

78361
atctctatgg cagcaatgtg gaggatgaag taacaaaaat atacactttg gttcattttg

78421
ttctaaatgg caactttacc tttaactgtg tacagagctt actgactata ctcaagcaac

78481
aaaatgcaca cttggaaatc ctgtgtcacg tgcctatact agctttgtcg ctgattcagc

78541
atatacacat cctccagtgt gacaggattg tgtatggaaa caggtaagac tggtgaatac

78601
taggctgtgt tcaagtgtag agtctcatga ttatcaccaa tactgbgggc tctccctctt

78661
ttagatgagt ttttctacca tatctttggc tttacaaaat atattaacac agtttcataa

78721
tagatctctt ggaatatggt cgtttggtgt taagcattct atctggcaaa atgaaaaata

78781
agatggtaag agttatccta caaaaatcct aatgttctca agctactgct gaaattcttt

78841
ttctagtaat ttacaaaaaa gtccccattt tcttgtagaa ataagccaat taaaaaaaga

78901
aaaaaattaa aataaaaaat taaagttctt aatgataaat tatattaaaa tttatttcct

78961
gttttaccct atatcctatg agcgtggttc tcaaacttcg ttcagtgcat accagaatca

79021
tcatgtgcgc ttgttaaaca gaggtctggg ttccaccccc agagcttctg attcacttca

79081
tggaatctga gaactggcat ttctgacaag ttcccagggg atgctgaggc tgctggtcca

79141
gggaccacac actgagaaat attgttctga aataataaca gctaattttt gttaggcagt

79201
ttctgtgttc caaatacagg ttgaatatcc cttatccaaa atgcttgggg caagctgggt

79261
gcagaggctt attcctgtaa tgtcagcact ctgggaggct gaggcaggag gattgcttga

79321
gaccaggaga ttaggaccaa cctaggcaac atagcaagac actgtttcta cacacacaca

79381
cacacacaca cacagacaca cacacacaca cacacacaca aattgccagg catggtggca

79441
tatccctata gtcccagcta cttgggaggc tgagggagga ggatcacttg aaacaaggag

79501
tttgagacta tcctgggcca catagtgaga ccctgtctct acaaaaaata tttgaaaaat

79561
tggccaggtg cggtggctca tgcctatagt cccagcactt tgggaggctg aggcaggtgg

79621
atcatttgaa gtcaggagtt caagaccagc ctggccaaca tggtgaaacc ccgtctctac

79681
taaaaacaca aaaattagct gggcagtagt ggtgggcgct tgtaatccca gctactcagg

79741
aggctgaggc cagagaatcg cttgaaccca agaggtggag gttgtagtga gctgagatcg

79801
tgctcctgca ctccagtctg ggtgacagag tgagaccctg tctcgaacaa aacaaaacaa

79861
aacaaaacca aaaaaaccaa aacaaaaaac atattagctt ggcatggtgg tgcattcctg

79921
tagtttcata tgtgatctca ctactgcact ccaatgtggg tcacagagca ggactcaaat

80041
gaaaacaaaa ccaaaaccaa aattcttggg accagaagta tttcagattt cagattattt

80101
tggattttga aatattggca tgtatctaat gagacatctc agggatggga cccaagccta

80161
aacacaaaat tcatttattt ttcatataca ccttgtatac atagcctgaa ggtaatttta

80221
tataatattt taaataattt tgtgcacctg tcacgtgagg tcaggtgtgg aattttctac

80281
tgtggtgtca agtcaatgct caaaaaattg cagattttgg agaatttcag atttcagatg

80341
tttggattaa atgtgcttag cctggacctt acttgttgta gctcgtttaa tcctcatggc

80401
aatgctagga cacaggtggt tttagtataa tattattaca aatgaagagc ctgagacttg

80461
agaaagtaag acaacacact ccaggtcact cagccaatta gtggtgagca agaattgaac

80521
ccagatttga tatgcgaatg acttgctgtg attctcctat tggtgatttt tttttttttt

80581
tttttttttt ttgagacagg gtcttgctct gtcacccagg ctggagtgca gtggcatgat

80641
ctcagctcac tgcagcctct gcctcccagg ttcaagcgat tctcctgcct cagcctcctg

80701
agcaactggg actacaggca tgtgctacca tgcttggcta atttttgtat ttttagtaga

80761
gatggggttt caccatgttg gccatgtgga tctcgagctc ctgacctcaa gtgatccatc

80821
cgcctcggcc tcccaaaatg ttgggattat aggcgtgagc cactgcaccc ggccccttat

80881
tggtgtattt ttatttccca agtatgacac ctgttcagag actttggaac cctgagaaca

80941
ttttgttggt gtgttttgtg actaatattg cctttttctg agatgaatgc tgttctttga

81001
aaaaacattt gtatttttag atagaaatgt acttcatccc cagtgaatat ttctgacttt

81061
agagaaattg ccaaacctgc tgactcataa caaaaataaa gagcatctac tattcagttt

81121
atggctttta gttttgggag gtggtaggag gaaggataga ttaccaccca ctatagatca

81181
ttttattttc attttatttt aatgccattt accagtattg tgtatatgga ggtggtcttg

81241
agagctttgt ggagattatt ttttcaatag tacagatggc tctgataaat atttaaggca

81301
tcttgggaaa caagaatacc atcctgactc aggagaaatt ggtcacgtaa atcactttgt

81361
ttcaagtgct ttggcctctg agcatctcaa atggacacat acttcattgg cttattaact

81421
cattgccgga gtcactgaag gcccaaacta caacttcatg cctgaccaca caccaaggct

81481
tttttattgc ttagttttct ggctctttgc ctattctgct ctccctaccc ataaccatgt

81541
gagtatcatg tccagcaaac taacttactc cttctctctc cccactacac acacacacac

81601
acacacacac acacacacac accacactcc acacgcacac atacacagag catttttcat

81661
gggtatgttg tcagacagat ttctctgttc tgaaggctca tctccttaga gaaccttacc

81721
gtgtcaatgt tgcatttagt ttagtttagt gttgttgttg ttgttgttgt tgttgctgtt

81781
tttaaatctt gctctgttgc ccacagtggc gcgatttcag ctcactgcaa cctctgcctt

81841
ttgggttcaa gcaattctcc tgccgcagcc tgctgagtag ctgggattac aggcccccgc

81901
caccatgtcc agctagtttt tgtattttta gtagagacgg ggtttcacca tgttggctgg

81961
tcaagtcttg acttcctgac ctcgtgatcc acctggcttg gcttcccaaa gtgttgggat

82021
tacaggtgtg agccactgcg accggcbgtt tttttttttt tttttttttt ttttttcttt

82081
tttgagacgg aatttcgctc ttgttgccca ggctggagtg caatggtaca atcttggctc

82141
attgcaactt ctgcctcctg ggttcaagca attctcctgc ttcagcctcc caggtagctg

82201
agattgcagg tgcccaccac catgcctggc taatttttgt attttagtag agatgggatt

82261
tcaccatgtt ggtgttgtat ttagttttaa cactgttatc ttctcagatt gtaatgagag

82321
aacaggctat catcacttgg tgataaaatt tcctgtaatt ataatctcat tctcaaagat

82381
aaaacattga tacctaatgt gcttttaact ttaatgccaa tttatcacaa tggaagacat

82441
ttcaaataaa tactgttttt ttgttcataa ggtcttaaaa atcttgaata taactgcaaa

82501
aaagcattac atgttaaaag aaatcacaaa attagttaag aaaggagcca aactgaaaga

82561
agattatatt tctatgccct tgaatcttta caaaatttag taaaaactat taatatagaa

82621
ttatttacaa gagacttctc tatttaccag cccaatatct tcacatttct acaatctaag

82681
gggaggtgat tgtggccaga aaagtttctg ggctctggta ttgcagtttt cctgcactta

82741
ccaccatccg gcatgttata tattttactt atttttcttg cttattgctg tctctttcca

82801
caagttccat gagcagagac agtttatctg tgttttttac ggctattctc aatgtctgta

82861
acagtgtcta acgtactata gtcattaaag aaatgctggt tgggtgaatt cagaaataaa

82921
ttagtaaata ggtgaagcat gttggtttaa tattcatcat cagaacttaa aaacagttta

82981
aagaacctca actgagtttt gtacaataag tagtgacaag gtgggacaga ggtaatttct

83041
ttgtatctct gaggctttcc atttcatgag gaacatagaa taatatgtgt ttccaaatgc

83101
agtgttcaat atctgaagag tatatatcat cagtatagaa aatagacaac acatgttaaa

83161
gggaatgtaa aaattctaga tgatttttaa ggtatgtatg gtttaatcaa ttgtttatat

83221
gctattctct tctcttaaaa tgaaataatg cgaatgaaaa aataaacctt acaggtagtt

83281
tctgggaaat tcagacaaca aaattgtcta acatacgcca aaaacaatat agcatttaat

83341
gatgacatgg attccgaaag acaaatcact gctcatcata ttacaaggaa tccaaacaac

83401
tgaggggtta tcatttatct atagttgcat aacaaattac cctaaaattt agcagcttaa

83461
aacaacaatt tattatttca taaatttctg gggatgagga atccagaagc agattcactg

83521
ggtggttctg gctcaaagta tcttatttgt ttgctagggc tgcbgtcaca gaacacaaca

83581
gcacaggtgc cttaaataac agaaacatgc attctggagg ccagaagtcc aagaccaagg

83641
tttcctctga ggtctccgtc cttggattgc agatgcttgt cctcttgctc cctcttcaca

83701
tggttgtccc tctgtgcaca tgcacttctg tgtctctttt tgagtgaaaa tttataagca

83761
ttccagtcag attaattttt tttttttttt tttgagatgg agtctcactc tgacacccag

83821
gctggagtgc agtggtgcaa tcttggctca ctgcagcctc cacctccctg gctcaagttc

83881
ttctcctgcc tcagcctccc aagtagctgg gattacaggc atacaccacc acgcctggct

83941
aatttttgta tttttagtag agacgtggtt ttgtcatgtt gcccaggctg gtctcgaact

84001
cctggcctca agttatccac ctgccttgtc ctcccaaaat gttgggatta caggtgtaag

84061
ccattgcacc ctgccccagt cagataaaat tttaatctca ctttaactta atcacttctt

84121
tgaaggccct gtctccaaat atagtcacat gaattagggc caagctgtat ggcttcattt

84181
aaccttaatt acttctttag aggctctatc tgcaaatgcc tccacattct gaggtggtgg

84241
gggggttagg atgtcaacat atgaatttga gggggcacaa tttagcccat agacacctgt

84301
catgaggttg tagtcagctg tcagttgggg ctgcaatctc atctgatgga ttaactgggg

84361
aaagatgggc ttcccagctc actggtgtag ttgttggcag gcctcagttt cttctcgctg

84421
gagacttcag ttcttgccat cggcttctcc acaggttgtc cagattacct aatgacatag

84481
cagctggctt ccccaaaagc atggaatggg ggttggggat gggataagag agagagaatc

84541
caagacagaa tgcacagtct tcttataact taggtttaga aataatatat cagtacctct

84601
gccacattct gttggtcaca cacactaacc ctggtaaaac atgggagtga accatacagg

84661
gggaactggg gtcattggtg gtcatctttg aggctggcta tggtaattag gtaaaaataa

84721
aaattcagtc tgcagaaacg tatgtactta tgttacttaa aatattttaa ccaattagtg

84781
aaaaatgact ttgaagtatt tttagctgct ataataattg agtaggaatt attttttctt

84841
ggattgagtt atatttacta taaaaatact tacttttttt gtcaaacaca tttataagtg

84901
ctgcaaatat tagtgaccaa tggtctattg ctctaaataa aaagcaccag gagttagtat

84961
agtagttgac tccagcctct ggtgctagac tgcctgggtt tgaatattta cttttgcact

85021
tacaacttgt aacaacttga acaatttatt caatctctct gttccctagt tttctcatat

85081
gtcaaatggg agaaacaaat aacatctgct tcatatggct gttatgaagg ctaagtaggt

85141
ttatatatat gtatgtatgt atgtatgtat gtgtgtgtgt gcatatatat atatatatat

85201
atagagagag agagagagag agagagaaag agaacttaga atagggcctg gcacagagaa

85261
tatgataaaa gaatattatt tgtttcctct ttttatcatc cagaacatgg tgtaatgccc

85321
aatacattgt agatactcaa taaatgtttt tgtatgatcc ctaaacattg tctgtaagga

85381
atttacaatg gagtttacag taaaaggtgg tacatggtag gtaccatgga agcattacaa

85441
acagatgacc atgtgaatct gaaagaagca cagattgatt tcttcgtcat aaaacatggt

85501
tgtatttgag ctaaagctta gaactaatga agattattgc caggcgtggt ggctcacgcc

85561
tgtaatccca gcactttggg aggccgaggt gggaggatca caaggtcaga agatcgagac

85621
catcctggct aacatggtga aaccccgtct ctactaaaaa tacaaaaaat tagctgggtg

85681
tggtggcggg cgcctgtagt cccagctact caggaggctg aggcagaatg gtgtgaaccc

85741
aggaggtgga gcttgcagtg agccgagatc gcgccactgc acttcagcct gggcgagaat

85801
gcaagagtct gcctcaaaaa aaaaaaaaaa aaaagagtat caatgtatca aaatcattat

85861
tttaggctgg gcatggtggc tcacatgtgt aatcccagca ctttgggagg ctgaggtgag

85921
agatcacttg agcccaggag ttcaaggcca gcctgggcaa aatggtgaga ccctgtctct

85981
acaaagaaaa aaaaaagatt attattcccc aaataggaaa taacataagc aaacgtcccc

86041
tatttccccc acgatggagc tggagcatgg tgtatgagaa ggagagtcag agggagcaag

86101
aatgaagggg tcaggttggt accaggtaat gaaatcattt taacataaga ctacatgatt

86161
tggacttcat tgtgtggtca cttcggagca ttttagcaac aaaataatgt cttaggaaga

86221
ttaatctggt ccaattgtaa agtaaattga gattcaggct tcaggcttgg cttgatccag

86281
gattcaaata aaatcaccaa gaatctgtat ttcagatctg ctttttttgt gtggctctgc

86341
ctgtggctcc ataagaagca cagaaaaaag agaaatggtc tgttaaacag aaaaagtgaa

86401
aaagcttcac tcccagaaaa tatcttcttg catctcatcg gcctgagttc actcatgttc

86461
gtattcttca acaaattatc atgtccagga tatgaaacgg ctgcttggat ccaggcacac

86521
tgataacgct gataccacac ctagaaaaag aaatgaattt cattcaaatt ccattctact

86581
attttaaggt ttcatgtcta gatggctgga gattaagtgt tgcagtccag gcgtggtggc

86641
ccacgcctgt aatcccagca ctttgggagg ccgaggtgga cagctcactt gaggacagga

86701
gtttgagacc agcctggcca acatgatgaa accccatctc tactaaaaat acaaaaaata

86761
gccaggcttg gtggtgcgtg cctgtaattc cagctactcg ggaggctgag gcaggagaat

86821
cacttgaatc caggaagtgg aggttgcggt gagccaagat ggcactactg cagtccagtc

86881
tgggtgacag agacttcatc tcaaaaaaaa aaaaaaaaag taagttttgc aattaggaga

86941
catgcctata atgtttattt agtggtgata cgtatggttt agtcctttaa ttatagtgtg

87001
gtttaaatgc aaatttaaag taactcaaat acagctattt tttctcacat catagggaga

87061
ctataaagtc cctcagtaat cattcttcaa atagatattt ttcttctttc atctactgcc

87121
ttcacgactg cagtcacttt ctccaacagt cttttctcca aataaaaaca aaaacaccac

87181
taccaccact accaaaaatc tcaagtacct gctatctctg atctttctca tctgctaata

87241
ttctcttcct cccttactcc cctcctcttt tcttcctttc ctccttcccc atctctccat

87301
ctcacacctc cctctcttcc tacctccctt tctttcaacc ttttcccctt ctattcttcc

87361
ttccctcgct tcctccttcc cttccttcct tccttccttc cttccttcct tccttccttc

87421
cttccttcct ttttgctatt aaaaattcct caaactggct gggtgtggtg gctcatgcct

87481
gtaatcctag cactttggga tgccgaggtg ggtggatcac ttgaggtcag gagtttgata

87541
ccagcctggc caacatggtg aaaacccgtc tctactaaaa atacaaaaat tagtagtgta

87601
tggtggcacc gcacctgtag tcccagctac tcagaagggt gaggtgggcg aatcacttga

87661
acccaggagg cagaggttgt agtgagccga gatcgttcca ctgcattccg gcctgggtga

87721
cagagtgagt gagactgtct caaaataaca acaacaacaa aaacaaactg gcaatgcagg

87781
acttccttga aagacagagg aaaggaaaag attaagagaa gttataccaa aactcttttt

87841
aataggtagg cagggaaaaa attgggaacc tttatacatc aataatttta ttctcataat

87901
acttggaaat catgactagc tgttgctctt cttcaacatc taactattat catttccaca

87961
tctgattcaa gcacttcctt tttacatgtc tttttttttt ctttgcctga aatattattt

88021
ccttccatca aattaacctt tctgcccacc tggcaaccct ctcttcttca agccttactc

88081
atcaagaagc cttccctagc aacagggaag gctctgctac caatcccacc tttatgctct

88141
ctggactacc actttgtctt gtacatttct attaaattgt aacttttcat ttttgttaca

88201
catctattga ctctactgct cagtgaacta tttgagacca ggacaccatt ttgcatacct

88261
agcacaatac ctaccacata gtagacattt cataaatcct tattgattga ataaatcaat

88321
gatgaataac atttttataa atttcatttt gtatttgagt tgaagctcca agtattacac

88381
cctgttagag attttaaact tgatttttaa aatattggac tagagcttaa aagaagatta

88441
tattagtcag gggtctcaag agaaacagaa tcaataaagt atacatttat tatataattc

88501
attataagaa attggctcac atgattgtgg aggctgacaa gtctcaatac ctacagtcgg

88561
caagctagag acccaggaga acctatggtg tagtccaggc tcattccaaa ggcctaagaa

88621
ccaagcgagc caatgatgta gttctagtgt gaaaacctgc aggctctaga cacaggaaga

88681
agccaatgtt tcagttaaag tccaagggca ggaaacacca aggtcccagc tcaaacatag

88741
tgagacagaa ggaattctct cttactcagc cttttgttct attcaggctt tcaacagatt

88801
ggatgaggcc cacccacaat ctgctttacc cagtctactg atttagatgt taatctcatc

88861
cagaaacacc ctcacagaca cacctagaat aatgtttgac caaatgtctg ggcaccctgt

88921
tacccagtca agtggatgca taaaattaaa caccataaag actaaagcct gtagatgaat

88981
atctggtaac acctcacaga ggagagacct aaagctgtga taacgtctct gaagccaaga

89041
gagaaaggct agaaaaagca agatctggga tatttcctta gaatccttgc ctgaaggcca

89101
agaagatgag gaagttaatt ttctcatcca gagtggtggt atcgagctag aaaattgtga

89161
agatctttct agttctaaaa catctgttac ctccttacct tggggtttca agactgggta

89221
aatggaaata ctaagataat tggatgatgt aagaagattt tggatgggaa caatatcttg

89281
ttatgcacca gttgtatgga aactacttat ttataagatt taaaattcta cgtatattcc

89341
ttcaggaaat gttgtcggct ttctacaaga tgcagcttta attgtattat tgggaaccat

89401
cattgattat taggttcttt ggagaaattt ctttccttca attagaagca cccatgaagg

89461
atatgaagaa gagttggtca aagaactata agaagatcat agaatgtact gcactataga

89521
agccaaagga agaggtaaat caagaggcaa gaaatgatgg aaaggtattt tgctatagag

89581
aggtaaaggt tgataagact tgggaaaaag gccatcggat tttacgatta ggatattaag

89641
gacaagtttc agccaagtca tgagaaactg agcatcagtt aggtccctgt tgtttgatat

89701
tatgacaatg tggtggattt agtaattaga gtctttcaaa attgtctgtt agtgctttgc

89761
agcttggggg catgagcaga gaaggtaggg ggcaggagga atggggagca tgtctgtggc

89821
tgagagttga aggcttgaat ggtaagagta ggcttgagga ttgtggcttg ttagaaaaga

89881
cagcattaaa atatctgaac atgggacttt gtttttagaa aggatacaaa tgaagttaaa

89941
agccagaaga aggtcttggg tgggattttc aagctgcatt ccttggagtc ttgaatcgtg

90001
gattagagaa aagaccaccc tgtgttgatc tcagtagctt ctcctgttaa acatcacagc

90061
acatgtgctt tgaccagttt tgtatattaa ggctctatgt ggctatcttc tgtcccgctc

90121
tgtcccccac ggccattctc tttccttcac catgctgctc tatgacccgg gaggctgacc

90181
tatatggacc atatcagtgg gctgctttgc cctcctgctt ctgtttggat tttgcccttg

90241
gggagcactt gcatgagctt gcagggaggg agaatgagag gcaaggtata atctgctgtg

90301
acctacaggg tcatcaggat cctttcccct tcaggcctag agttggtaat aatgcccagc

90361
tttcttaggc ccttgaaatt tctctatacc ctgctatatc tgttcaattg cctacataac

90421
ttaaccagtg tatgcttact actcactgca gccttgatct ccctggctta ggtgatcctt

90481
ccacctcagc ctcttgagta gcbgggacta caggtgtgca ccaccatgcc tggttaattt

90541
tttgtatttt ttttgtagag acagggtctc accattttgc ccaggctggt cttgaactcc

90601
tgggctcaag caatcctccc accttggccc cccaaaatgc tgagattaca gacaagagcc

90661
accactcccg gcccaaacat tttttttttt tgtaaaaagc caggcagtaa atatttttga

90721
tctgtgagtt atacaatctg tgttaccacc acttaactct gctatctcag tgagaaaaca

90781
gccatagatg ttaagtaagt gaatgaatgt agcbgtgttt caataaaact ttatttacaa

90841
aaacaggcag tgagctttgc ttttggccca taggctataa ttgaaagacc catgatctag

90901
gacaagaagt tttccatcta ctctatgaga gtggttctca atctgggata atttagctcc

90961
ctaagggaca tttgttaatt taagacattt ttggttgtca caactggagg agtagtgcta

91021
ctggcatcta gtggataaaa tccagggata ctgctaaaca tactgcaatg cacaagacag

91081
cccccacaac aaaaattacc ctgcccaaaa tatcaatagt gctgaggttg agaaatgctg

91141
gtcttgaaga tgttaaaaag attgtcagtt tgttcatcat atcgctgtgg cttggcgaaa

91201
agaatcacag agttaatttt ataactatga aggattgtta ggagctgagt ttttttctag

91261
ttcttatttt ttaattattt tatgatactt ttcataaaaa gtggtgtaag ttgtgtttat

91321
tcagaaatgt gatttttttt tttttttttt gatggagttt cgctcttgtt tccgaggctg

91381
gagtgcaatg gcgggatctt ggctcactgc aacctccgcc tcccgggttc aagcgattct

91441
cctgcctcag cctcctgagt agcbgggact actggccacc atgcctggct aatttctgta

91501
tttttagtag agatggggtt tcaccatgtt ggccaggctg gtcttcaact cccgaactca

91561
gatgatccac ctgcctcggc cttccaaagt gcbgggatta caggtgtgag tcactgctcc

91621
cagcccagaa attgatggtt tctttagcaa ttttgtcacc catcaagtcg ttagtcatat

91681
taatcctcca taacttagtc tttttgcccc ctgattatct tttgggtggg cagtgaaagt

91741
attcatacct cttttagcaa aacctatctc ttcttggatt tcctttgctt gctgattaag

91801
aggaaggact atctgtgaaa gactcagatg tggctcaatg gaatgaatgt gagaatggta

91861
tgagtgtggg tggtgggtgc tgtgggggtc ggagatgagt ggctgaacca tccaaaaata

91921
agaatactga caagcgtgtt ttcttgtgtg tgtgtgcgtg ttgtgggagg agtgtaactg

91981
atgtggctag acaggattaa cgaaagtctc aggagttgag agagactggg gacattttac

92041
caatggcgag aaggaggaag gatgacagct gggaaaatta gtgattggaa aaggtaggct

92101
gggcagtgtg gccatgagct agtccttttc attatattct tctggggctc tatgtttaaa

92161
actagatact ttaacatttc agaatgagaa agagaggaaa ggatggtaac tgatatgggc

92221
tattatactg tgaattttaa aggagcctat atattatcct aaaactattg aacctgagca

92281
gaactgcaac gttggtattc ttgaactgaa ctgatatttc ctttgactaa tgtccttgtt

92341
caatgaccag agaccatgac actccccacc ttcaccccca cacattgttt gtttgtgtcc

92401
agtttgaaga acaatgacac atggaggtca gtgtttggat gatgtcataa ttttgatcag

92461
ctggaaagcc tggagtggcc ttgaagagat gcttaacttt tggaaatcac ttctttattg

92521
caaccaaagc tattaagttt aaaggtccat aaagatgaga taaacagtca taaaggcctt

92581
ttgaaattca tacttagtgt gttaaatgga tttaattgct gttagttaaa tgtggtgatg

92641
ttaaagcaat gtctatacac tggcaaaaat cagatcatca actgcttaat gagggacacg

92701
tcttgagaaa aacagtggaa gaaatgctgc ttatatgtaa tttgtgatta atttttgcaa

92761
ggttttcaag ggaataactt ggccttaaaa tattacagtg aaaaacagct ttatacttgg

92821
gtccaatctt cttaaaatta gagttcattt ttgctattag acacctttta ttacaggata

92881
actttttctt cccccttgga gacagagtct tgctctgttg cccaggccag aatgcagtgg

92941
cgtgatctcg gttcactgta accaccgcct cccaggttca agtgattctt gtgtctcagc

93001
ctcctgagta gcbgggatta cagtgcctgc caccatacct ggctaatttt ttgtatttta

93061
gtagagacag ggtttcatca tgttgctcag gctggtctga aactcctgag ctcaggcaat

93121
ccacccgcct tggcttccca atgtgctagg attacagatg tgagccactg agcccagcca

93181
gttataggat agcttctaaa cttacaatcc ttgaaatatc attttaggat aattctgatc

93241
ctgcatacca gtgaaataag tataattgaa atattaaacc aaatttggct tcaacattaa

93301
accaaaatta aaccaaatta agccagtatg ttaaatacat agtttaatct taattctagt

93361
taatattttt catttcctat gtgtcaggca atatactaaa caacttacat gtattactat

93421
tttaattctc ctggtaaact ggaggggtgt gcaattattg tcatctccat tttatagatg

93481
aagaaaactg agtcataaag aggttatgta cttggctgaa agtcacacag tcagtgatac

93541
tgttggaatt tgcacccaga caatttaatt ttagagccta ttttcaacca ctctctgaga

93601
ctgctttcct tttctgtact tttgatgata aatgtgaaaa gataattttg agggcattat

93661
ggtgtattgg atcttaaaaa cccaggtaat aagtcccatc tatagtacaa ataagctgcg

93721
tgatcttagg gaaatcacat aactgcttct gtaaaatgag agattacatt aagttatttc

93781
caaaatgtct tttcgacttc aatgtggtga ttccatagta atgtataggt ttttaaaaaa

93841
ccatatcctt caatcaaatg gtcatccttt agcattaagt tgtttggaat agatactccc

93901
caaattcaca gaataatttt ccagcctctc tttttgcttt gacacctttc ttattttttt

93961
tttttttctt cgagataggg tctcactcag tcgctcgggc tggagttcaa tggcacgatc

94021
ttggctcact gcaacctctg cctcccgggt ttaagcaatt cttgtgcctt agcctcctga

94081
gtagcbgggc tacaggcgtc cgtcaccaca ctcagctaat tttttttaat agagatgggg

94141
tttcaccatg ttggtcaggc tggtctcgaa ctcttgacct caggtgattc ctcggcccta

94201
gcctcccaaa atgctgggat tacaggcgtg agccaccgtg cccgctattg accccatttg

94261
ttgatgctta gggatgaaag tggaaactcc actgctaaaa cagagaatat tacttgagtc

94321
attcctctgt catatatggg atgtttgcca gcatggaaca ttcacagaaa ttataactgt

94381
aaaggcccta gcaatgattt aatgccgtct cttcacatta tagttgggga agctcaaact

94441
gtgacagggt cagggacagg taaaattcac aaagttggtt tacagcagaa ctgtgctaca

94501
gttatctgga ttcagatcca agtcccctcc aaatgaatca caaccacttc tacctttata

94561
attccaggcc atgaaagatc actgttttag tctgcgtggt gcagtggaac agatagacct

94621
cggtttgaat ctcagctcta ctgtttacta gacatgaaat ggggaaatct aaaatgagta

94681
agtatacaca gaaacacaca ttacatacat atatgtaatg ttcaggatca ttacactgaa

94741
ctttagggct tagtactaat gtacaatcaa ggttgtgtta gtactgagca gtatatcttt

94801
tattgttgaa gtccaataag aacagagcag atatcaacct aatttgtaag tgatgcattt

94861
tcctaaacta aatgcccaat aatggaatgg gctagaatat tgcaggacag ggctgtgaat

94921
ggaggaaagc agttggaaaa tcaatccttt taaaggcaca aaaggatgaa tgaaccacat

94981
tcccaagaac ctgctcccac ccactgctgt tcccaccccc gctgtagttg gtagcatgtt

95041
cacaaggaag gagctggcta gctttcatgg gagccacatc atccatcaaa tcacattagt

95101
gttgttgatt tgaatgttgt ttcctttgta ggtctgcttg ctttgacttt gtaaaattgt

95161
ttagtcttgc cattattata taaggactat aatcataagg catttatatt tcattttgta

95221
ttatgtattt aagcaaaatt aagttaaaaa ttagacagag atatatagga tgatttttcc

95281
ttcaagagtt attcatttat ttccttttgg atatgaaaaa cgcttatgca gtcctgtatg

95341
tggtctctct ctctttttat ttttatttat ttattttttg agatggagtc ttgctctgtt

95401
gcgcaggctg gagtgcaggg gtgctatctc ggctcactga aacctctgcc tcctgggttt

95461
aaatgattct cctgcttcag cctcctgagt agcttggatt acaggtgcca gccaccatgt

95521
ccggctaatt tttttgtatt tttagtagag acggggtttc accatgttgg ccaggctggt

95581
cttgatcctg acctcaagtg atccgcttgc ctcagcctcc caaaatgctg ggattacagg

95641
catgagccat tgtgcctggc ctgtggtctc tttttaaatg tttgagattt tctctgacca

95701
tcacatgatg gcagccgcaa gttgtaaata tattaaatga gataatacca aatggcataa

95761
gaccactgtg aattcagtga tgttccaaaa taacttgtat tttattcatc acacaggcat

95821
ttatataaat taaaaaataa tagcacctga aaacatgaaa ataattgtat tcaaggttat

95881
ttactgcagc atgattttta agagaaaaga ctggaaacaa cccaaatgtc cactaatcga

95941
gactgtgtga acccaagatg ttatagctgc atcacacagc tgagagaagg aataagatct

96001
atttctactc actgccagtg gtaatctcca ggaagcgctg ttaagtgaaa gagcaaacta

96061
gagaaaatgt gaatagtggt taccatttac ccaagaagtc tatgtgtggt gtgtgtgtgt

96121
gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt atgtgtgatt tctagaggga cagaggaaaa

96181
aggtgaagac aaggatagga gcgagacttc tctgggtaca tctttttttt tttttttttt

96241
ttttttgaga caaagtctca ttttgttacc caggctggag tgcagtcgct tgatctcagc

96301
ttactgcaac ctctgcctcc ggggttcaag tgactctctt gcctcagcct ctcgagttgc

96361
tgggattaca ggtgcccacc accacgcccg gctaattttt gtatttttag tggagactgg

96421
gtttcaccat gttggccagg ctggtctcct gaccttaagt gatccaccta ccatggcctc

96481
ccaaagtgct gggattatag gtgtgaacta ccatgcctgc ctgtctggat ctctttttag

96541
tacatttgac tttgaagcca agttagtatt ttccataatt aagaaaaaaa tagaataaaa

96601
aaggaacaat ttctaaaaag gaagtcaaaa gaaacacatt aaactaactg taagttgagt

96661
tggtagcata accacacaga cagaaattat ttcaagtgac tttaacacat actgatgtga

96721
ctgtgcatcc ctatcgagat agaaataaag gtaaatataa ataaaggtaa aaataagcaa

96781
gatataaata aagttaaaat gaactgcaac aatcctgaat agttttcaat aattatatca

96841
taaatagtaa ttttggtatt gttattttaa aacagttata tttataatac atatgttaat

96901
gtaatcatgt ttatgcttat cataacatat ggatgcacag ctattaggat aatgtataaa

96961
catgattatg ttaatgccat tagggaccaa gatttcagag aaaaacaaag aaaaatataa

97021
aattaaagaa gccagtaaaa atgttatctt aaatttaaac tggaaacctc agtataaact

97081
cataatgtgt tttcttttaa aaaattattt tcaaattcag tctcctgaat agaactcgca

97141
acaattacca agccagtagc aacgacaata aacagcccta gtgcccagat ggtgctctcc

97201
aaatgccatt ttccactaaa aggaatgagg gctccttgga gaattggatg ttttcagata

97261
cagagcagaa cacatacaaa aagttcctgg aacatttgtc atactgaaaa gcagatacac

97321
tatgaaagac tatagtaatt gtatcaaaag aactcaggag ccaccatgaa gaggccccca

97381
gtgtccagaa atggaataat gtgaacatta agaataataa atcttaattt gtcaagatac

97441
aaatttaatc atatcgtaga tactcatagc agcattattt aaaataatga aatattagac

97501
acaacttaaa tattcaaaac tagcagtgtg cccttatata tagaaatgtc atttaaacct

97561
tgtagaagag aagtttatga tttaggaaga tgtttacaat atgctgtaaa acacacacaa

97621
caagtcataa aatattatgc atgcagtata ttccagttta ttttaaatga tctaggtata

97681
aatatccata aaaagaaaac tgaatgaata aatggtgaaa tgtgaatagt tgctatatct

97741
gtgtggcagg attacaggtg gttgtattct agtttctctt tatgttccaa tcttctacag

97801
ttagcatgta taattttata tttttttaat acaaaatatg ttatttaact agtatttact

97861
aaacaaaaaa ttaaaaatta atatatttta taaaaacaaa agcatatgaa tagaaaagta

97921
cattattttt taggttatag acaatgcttg tacctgtgtt tagggatttg atcctccagg

97981
taggaaacta cagatctaat ttaacttatt taattaatta attaattaat taatttattt

98041
atttatttac tttgagacag agtctcgctc tgtcaccagg ctggagtgca gtggtgtgat

98101
ctcggctcac tgcaacctcc acctcctggg ttcaagtgat tctcctgcct cagcctcctg

98161
agcagctggg actacaggca tgtgccacca tgcccagcta atgtttgtat ttttagtaga

98221
gacggggttt caccacgttg gccaggatag tctcaatctc ttgaccttgg aatccaccca

98281
cctcaccctc ccaaagtgct aggattacag gcgggagcca ctgtgcctgg cctaatttaa

98341
aaaattttta agtcaccaaa aagcaaagtg acatgctcaa gtccattatt gccaagcaaa

98401
gaaaaaaatg tcaaaagtac aaaatgtggt tatgttttaa aaattagatt attattatta

98461
agataggatc tggctctgtt gcccagacgg gagtgcagtg gtgtactcat ggctcactga

98521
agccttgact tcttgggctc aaatgatcct ttcacctcag cctcctgagt agccgggact

98581
ataaggcagg caccaccatg cctggctaat taaaaaaaga attttttttt tgtagcaatg

98641
aggtctcact atgttgtcca ggctgatctt gaatgcctgg actcaagtga tcctcctacc

98701
tcagcctctc aaagtgctgg cattacagtc ctgaaccacc atacctagcc agatttctat

98761
tactttgaca tggtcctgga tacttcatct atgtgtgcaa aatttcgtac ttatctctta

98821
aatctggaga aaaatggcca aatttggtat agttgaattt atcatggggt gattaataag

98881
tgactaaaga ttgaccttca aggatctgaa gatctgacca gtgtagattt atagtaatta

98941
tagtaattac atggtacctc caggtatttt ctatacattg ccgtagttag ctatgaaagg

99001
atgtaaagaa taaaggcaat tgactatttt aaagaaatta acctcagaag gagattcttc

99061
acctaaatgt ccctgcaaat attattgctt tatgctctga gttagctgaa aatgagttta

99121
ctatgcctgg tgtaaacact tgcaccaccc acctgtgtca aagaactttt cactaactgc

99181
atcatgactg attgacgtca gtctacttgg caaccaagtg agccacttag aagaaggctc

99241
cccttatgag gttaatttct ttaaaatggt gaattgccct tattccttat gtcttttcat

99301
aactgattac acaaatgtat agaaaatacc tcttgagata caatacaatc tgtaactagt

99361
catcagagaa taacacgtta ttgtaacaca gatttagctt ggccataaag ggcatattta

99421
catacacatt gaaaacaact ttaataaaat gaaaaacata tatccttgga ttcttagcaa

99481
tttaacagca atgctctcag gggatcaagc tactatttat tgactccccc tgtgtgcctt

99541
acacgtaatt actgaccctc acaacatccc tgggagttag tgtcttacag gagacctttg

99601
acatttgtga gaggacatcg tgaatatttt ccaagtcctc aatccaaaag tgtggacata

99661
gctgttggtt ttcctgaatt gtatttcttt caagaatcaa atgttgcttg tgaatattct

99721
catgtaagat taaaaaaaat cttttcctga ctcttagaac tttagtttta tctctgcttt

99781
gagagccact ttaataagca aactaaaatc actctacaga aaggctgtac agcaaatgag

99841
tagagaacaa aagctggcta aactgggcag tcagctaaga tcactcagtg tctgagaatt

99901
tgttctagaa aatcaccctc cgagaatcat gcagattgtg cttaggcttc cttcatatat

99961
tcatactctc ctcgggtgaa cataaattgg cacatttata aggaaatttt attattatat

100021
actcaaatat ttttaaacat ataaatagtt tgtcttgtta attctacctc ttggaatcta

100081
tcctaaggaa aataatcata agatatctgc aaagaattat ttgaatgttg ataataattt

100141
tatctataac aataaaaatt tgcaaggtgg cagatatcag tttatgtctc tgagctccaa

100201
atccaccctt gtttatcttg ctttgtgtga atggagctgg accctgtgga tctttctctt

100261
ttgcaaattt gggggatatt caactttgtc aattgagggc actggagaga ccctgcaatg

100321
gaatagaggc tccaggtgca cctacaggcc atctttccct accagcagcg atttcagagt

100381
aacttcagcc tgtccatacc ctccagcaat ggtgggtcac ttctatagat gaactctggc

100441
ccacccgcag caccaagcaa aggaaggtca ctcctgtaca ccagcttcca accactctca

100501
tccaccagtg atgatagatt gcttttatgg atcaatgcca gcctttgcac tcagtcgttt

100561
ctttgttcct gcaggctgcc tgtggtagtt actatctctc tgaagaggtc tgaatctcag

100621
ccttggggca aggagggctt gtcctcatcc ttagtgcctt tactgttctt cttcctcagc

100681
ctagaaataa tagctccttt taaaattctt gatgcctggg cctcttagag tcctccttta

100741
tatatctttt agtaggtaat ttttggaaca ttaaattttc cctgttcaaa taattatcat

100801
agtttttgtc ttccacttgg accttgaatg atacaaaagt taaaggctca acaataccag

100861
acttgttaaa taagtaggga gctatccaca cactggcata aaattgtttt gattatctat

100921
tattcccttg gtgaggtgac ccagaccctt gtttgaaagc gttttattgg ctgggtgtgg

100981
tggttcatgc ctgtaatccc agcactttgg gaggctgagg tgggcagatc acctgaggtc

101041
aggagtttaa gaccagcctg gccaatgtgg tgaaacccca tctctactca aaagtacaaa

101101
aattagctgg gtgtggtggc gggtgcctgt aatcccagct actcgggagg ctgaggcagg

101161
agaatcactt gaacccgggt gtcggaggtt gcagggagcc gagattgtgc cactgcactc

101221
cagcctgggt gacagagcga gactccatct caaaaaaaaa aacaaacaaa agaaaaacaa

101281
caacaacaac aaaagaaaaa acaaaaatga aagaaagggt tttatttgtc ttctctctct

101341
ctccctgttt tttttttttt tctttttttt ttttttgtct catctttgct gtaattgctc

101401
atttgctagg gtcattggac acagagatac caagatgtct tcagaaatca tgaatattcc

101461
ccaagtcctc tatcaaaaag tgtggacaga gctgtcggtt ttcctggggt ttagacatgt

101521
tctttcttgc ttctgttgtg tagtaaccct agctcctcaa ggaaatcgtg gtctatgggc

101581
tctgccaaac agtaattcct ttctttgctt gctggctcac tggcttgagg aactcaaagt

101641
aatcctttgg taatttcagc ttccaggtca gtggggacat taatgtgttt cttggtagaa

101701
atgtcactct actccaagaa ataagatctt taatccagaa aacctgagtt ttcagggaca

101761
gaatgcacaa acttttatgg tcattcactg ggagttctaa tgagcaggtt cgatcatatt

101821
tctattcttt agttcctcga cccatgcatt ttagctactg ggcggcgaac catgtatcag

101881
ctgttagtgc tgtgtgtatt ccatatcatg aaggtaattt cccaggccca caacgttttc

101941
ttcccaagct ggtgccgtaa ctgagccttt accaggctat tccatcattt taggtgtttc

102001
tagggtatag agtaaatgat aagaccagtg actcccatga taaatgtgca ccatggtgaa

102061
cttcctttgc tgtaaaatgt catcttggtc ctagtctata tcgtaagggg caccatactg

102121
atagaccagg tactggtgag cccttggatg gtggtactgg tagaggaact gcaggaagaa

102181
aaggtaaatc catactcaga atatgtgttg attctggtaa ggacacgttg cttttccctc

102241
caagacagat ggttccgata gatggttgtg tagctaccct ccctgaggaa cggtactatg

102301
tcaaggtctt ggcatcagat tccgtggctg acaggttgga aatttagcat tgacagtagc

102361
tgaattatct tttgtaagtg ggagctcaaa tatgaccatg catagcacca tagtgattgc

102421
agcactagag acactattta tgggctttcc tgcacaagaa ctggggtggc taaagacggc

102481
ccggctaaaa ggcaggatgg atcatcctga gcacatggtt gttgagagtc ttctttgcag

102541
tcgggcggta gtgtgagatc tgctttgtgt ttatttccgt agggttgtcc acatacattt

102601
ttttccccac accttttctc tgagcttcaa atcttttttt cttgtcctgt cgaaatggcc

102661
aagccattca ctactgctta gaagccagtg catacttaag gatctggtct tttcttccat

102721
atgaaatgaa taactaagtg tgttgctcat agttttcccc actgggagga tttcccttta

102781
cctctcttct ttggggccac ctcaagtgag gatgaaatgc aacagcagac tatctctggc

102841
tagaggcaat aaatcacact agcccaatta tgcaccaggc ctgagctgtt tcctccacta

102901
ctgattgttt gtaggtagca gttgtgggag cttctgtgga acagattcag gtggtacagc

102961
tgctcaaact cataactcac ctgcaatgtg ttctgaaaat gtgtggctta actgcatcta

103021
ccctaaaaga acaagttggt gagtgatgag atgagtggga agtagtgagg atgacctgga

103081
ttttccattg aggaagtggc caagtcctgc ggacaaattg tacctaggaa aaggtacaaa

103141
aacaggagaa tggatcatgc gttcagtatt ggaactgatg actattaagt tgctgtgggc

103201
atctgaatat agatgttgtg atggttttaa aacatgtctg aaaattcttt gacactgttt

103261
ccatcaagag gtgatgtctt tgtctcctcc ccttgaatct aaatgggcct ttgtgacaga

103321
tctgatgaat agaatgcagg aatgtgatgt ccaaggctag tttagaaaag accatgtttg

103381
tttctctgga gacacttgct ctgggagcta ttagtgtcct tccaccaaag ccccccagga

103441
acacccctgc agctaaacaa attggattta ttgcttattg tagcaagaca gaacattcac

103501
cagggggaac cataggttat ctcagtaaga gggttttaga aagaacctat tataagattt

103561
gggctttggt tgggtgattt gggggaaggt ttaaggaatc aggggtggcc aggcacggtg

103621
gctcacgcct gtaatcccag cactttggga ggccgaggca ggtggatcac gagatcagga

103681
gatctagacc atcctgacta acacggtgaa accccgtctc tactaaaaat tcaaaaaatt

103741
agccgggcgt ggtggcgggt gcctatagtc ccagctactc aggaggctga ggcaggagaa

103801
tggcgtgaac ccaggaggcg gagcttgcag tgagctgaga tcgcgccact gtgctccagc

103861
ctgggtgaca gagcgagact ctgtctcaaa aaaaaaaaaa agaaaaaaaa aaaggaatca

103921
ggggtttggt ctagattgaa tgctctcaga aaatgggagt aattctaggg ttgtatattt

103981
tataggtggc atagtgacct tgttttgtct gtccttacac aaatgatgaa gtaggctgat

104041
tttgtttcat tttatcttgg tcgcagagta actttgtctg aggttggtgt tctataagat

104101
tgtatatgtc caacaagaga atgacatggc ttagctgtga atgtcagatc agttctggat

104161
atgagaggct gatattttct ttttgagctt tcagttgtca tgtaaggagt gtggctacca

104221
tgaggccact gcatagagtg attgtatacc tatatataag agagatggtt tggagttcaa

104281
gcccccagct agtcaagtct tcccagccca ggagacagat gttcgaatga aggagactta

104341
ggtaatttca gccccagtca ctgtctgacc acaactgcat gagagaccct gagggagaac

104401
tgctttgctg aacccagtca acctccagat ttgtaagtaa aataaatggt tatcattgat

104461
tgaagtcact gttctagggt ggtttttcct acagtaatgt cattgataca ggtgtctggc

104521
aggcagttgg ctctagaggt ctggagctaa ggagaaagat ctggcttgga gatgtggatc

104581
aggaagtcct tttacaagga gaaaagtgct tgaagtcatt tgagtggatg acatcacctg

104641
aaagataata tacattgaga aagaaaaaaa taaaaagcca acaatagcac ctttagtaac

104701
aacactgaag agagcaggaa gaaataaaga aacatttgca aggagacaga gaaggagtga

104761
ataaggtgat caaatggcat ccatccaaga gatgatgtcc aggaagccaa gaatgagagt

104821
atttcagaaa gaagagtgtt gtccacagag ttaaatgcta tggagagaga tggagtaaga

104881
caagattgat tagcaccaat gagctttcat tgttgacaaa tgcagtttga gggaaactgg

104941
gggctaggga gtgatggggc agagaccaga atgcagtggg gtaaggaggg gtaagaagat

105001
gagaagaatg ccaaatctgt gctgtttgcc acatcatggg ccctctctcc atactattta

105061
tgtgtgtata atttttttct acaatttaat aatgcattaa accatcacat cacatcacat

105121
cacaaaccca acaattccac aatagcatgg gtagatcata ccctggtgta tttttaatgt

105181
tatactttaa ccggtagttt tgagtcataa atgtactact atgttgttgg tttttttttt

105241
ttttttgggt ctgtcattat agtaataact ttaaatctct tattgtttat ttctcttgca

105301
attaaaatag ttcatcattt aaaatagtac ccagtgttca gtgtccattg gtgccttgta

105361
attacttcag aaaaacagtc tcagtttaaa agttataaac tcttaatgcc tctctgcagg

105421
aggaatagct tccttctgcc agagcggtct ggggagcatt attctagtca taccctgcta

105481
attcattggc ttgattgtca ggggtcctga tctagttcac cctcctggga ggctggtgtg

105541
ggaccctgct tatcccagtg ggggtcaagg cctccttgac aacagtgaat gggttgctag

105601
gaggctgcgg aaagaaattt ctctagttcc atccacaagt agatcccact gcagtggcct

105661
catttggctc ctctaatcct ctctttccca ccttctttca gggcaagtct caccctattt

105721
tcttcattac ttgcttgtgg tttccttgcc ggagatgctt ggaggcaagc attatgacaa

105781
ggatgggcgc gggtgggagt aaggccttta aacgaagagc tacatttcaa agaacttcaa

105841
atgtgtattt caaatgtcac ttccaaatga ggttgtacac acagacagaa acgcaattaa

105901
cagatttgga agaggccacg tagcatgcat ttgaaactcc tgttgcattc cttggctatt

105961
cttgtctgtg gcatcttttt aacaaatcct gtagttacct tgtaaatacc atcatagaat

106021
atattgtatt taaaaaacat tctttactca gatatgaaag ttgaaaaggt actattattt

106081
ttaaaaatct gtattggatt tttttttttt catattttag gatgccagaa gcctcaaaaa

106141
tggaaaaccc cctgtgcttc acatctgaaa atctctgctg ggggcagcaa ctttgagcct

106201
gtggggaagg aactgtccac gtggagtggt ctggtgaatg cttaaggagc tgcagaaggg

106261
aaggtagtga ggagacagtt aaatattgag cacgttttgg tgcctagcat tgtactggcc

106321
tttcacatgc tatgtttaat cacgcaggat tgtatggaat gggattgtac agaatgaggc

106381
ctgggtttgc taaatcctgg gggagattgt ctaagcbgtc acttgaaggg aaaactgtag

106441
catgbgggac ttaaaaacag cttgggatgg agtttgaggt agggcgagag ggaaaaagat

106501
cttggcagat acattctgaa caaatacttg tgtcatcctc aactgtatag tttttatgac

106561
ttttcctgtg ttcatctggt tggcagatga atgcaaaatg ccttttagct tcatggaagg

106621
cacacatgaa tcatggctat gtgataaaca gaagaagcca cgtttcggag ggtttctggt

106681
gtgtgtacgt gtgcacttgc atgtgtgtgg gcacaccctt gtgccaaatg gaccaccagt

106741
ttaaatcgat tttcaacagg gcagatttca tatgcttctt tagtgtggcc caagtcaatc

106801
tatttttaga aggggaaagt agagcatgtt ctgaaagttc ttttcttctg ccatcaggga

106861
ttgtagtact ttttatttat agtaatttca ggtctctaaa tacttcaagc aaaattaatg

106921
aggcaaacaa aaaaaattag gtaccagata attggatcat gtgttatttt atagagagct

106981
ttatttatct tgcctttgga aagtataatt tgtatttttc aaaattatga ttagatctaa

107041
ttctttttca agatttactt aaaataaata tttctgccta ggcacaagac tgtgtatagc

107101
acaactggcc ttgtattatt gacttgatga tgcaaagaaa aatatataag aatcagtttt

107161
ttttaaatgt gttaatattt atcataatgg aaatagtctt actaattagc aataactaga

107221
aaaatgtcta ctatttattg agccactact atatgccata ttctttacct atgttcattt

107281
tctcttctat attcaaaata atcctataag gtgtgcttta tgatcaccat ttgttccaat

107341
agggtctcaa ggacgttagg taattattcc tatgacattg agcctatgaa tggcagagct

107401
gggagtttga acctaagtct gatgactctg aagcttatag tctttctata agcttcttca

107461
gtctgaagct gcccctcaaa gtcatggcaa taactgagaa tagcattcag ttttacagct

107521
aggaaggtag ttgtagttgt gtttattatt caatactgtc catattcaaa gaaccattca

107581
ttgagcttct attttactcc agtcacggtg ataaataatg cagaatctag agatcaaaga

107641
taaaatggcc ttgccctcaa ggaacccatg agctagttgg gaaaactaat aggaatatta

107701
atgattataa tgcagaatgt taggtgcaat gagagaggta acaaggtact actggggcct

107761
gacaaaggcc accgtttctg tgtgtgtgtg tgtttatgtg tgtttgggaa aaggcaaaag

107821
acacttgaga taaagggaac aacatagaca aaatcaaagg cttgagagca tataacttat

107881
atgagacata gcaaattgtt tgctttaact agaaaatagt ggttatgtgt ggcagactat

107941
gagaaatgag aatgtaagtc cttgagaatg ataactttag aaattctaca tttgggatga

108001
tcataacctt ttaaaattgt ctcaatatga tagatatttt ccttctgttt tggggtatct

108061
gtctttttat tttttatttt tttgaggtgg agtctcactc tgtcacctag gctggagtgc

108121
aatggcgtga tcttggctca ctgcaacctt cacctcctgg gttcaagcaa ttctcctgcc

108181
tcagcctcct gagtagctgg gattacaggc gcctgccacc atgcctggct attttttgta

108241
tttttaatag agatggggtt tctccatctt ggccaggctg gtctcgaact cctgacctca

108301
gatgatccac ctgcctcagc ctcccaaagt gctgagatta caggcatgag ctaccacgcc

108361
tggcctgggg tgtccatctt ttaaagacac actgtaagaa tcataatatt ttcccaaaga

108421
agaaatgtaa ttagtacaca attacatgtt aaaactaggt gttattggta attaaaattt

108481
aaaaaaatta acccaaccaa ataataaaac taatgaaaat atttaatatt ggtaagaaca

108541
agatgcgata agcatatttg tgttttgctg attggtctat aaagtggttc aaaacttttg

108601
taaactatat ataagctatt ttaaatgttt atgccctttg attcaatagc actaggtttg

108661
gtactttata ataggaaagt tattagaaat atttactgca gggtttcttc aatgatgagt

108721
tgtaagaatc agcctaagta gctatggtac atcactttga tgcaacttaa tgtgtcatta

108781
aaaatcatgt ttatgaataa cattccagat gcatttaata caattctagc tgaaaaaaag

108841
atactgaaac attttgtgtt tatatatgtc tgcatatgta tctatatata tccctctccc

108901
tgtcaatcta taaattaaaa actatacatt aaaaactgca aattaaaact atatactaaa

108961
gaaagaaact ggaaagaaat ccacagaatg ttaataatca tggtcattgt gttgagtggt

109021
aggactatgg gtaatttttt ctttctattt ttatacattt ttcacttttt tttttttttt

109081
caatttgagg cagagtctca ctctgtcacc caggctggag tgcagtggaa cgatcttggc

109141
ttactgcagc ctctgcctcc gggttcaatc aattattcta cctcagcctc cagagtagct

109201
ggaattacag gtgcacacca tcacgcccgg ctaatttttg tatttttggt agagacaggg

109261
tttcactatg ttggtcaggc tagtctcaaa gtcctcccaa agtgctgggc ctccaaaagt

109321
gcbgggattt ggcctcccaa aatgctggga ttacaggtgt gagcaccaca cccggcccat

109381
ttttcacatt tttaatgatg tttttaactt taaaagtaaa aatttgtaat ttaaaatttg

109441
tttaactttt acaaataaaa attacaaatg caaattaaaa ttgctatata tttttgttac

109501
tggacaagaa aagatgcatt atagagtctc gttttatttt gttttctgat aaatctattg

109561
ctggggagca tgtgcgtaat tcgttttaaa aattctcagt gttaactaga tttcttttgg

109621
gatagctctg ctgaactgga atgagatctt cttccccaga gccacttgct agtttgattt

109681
tctagaaaga gagaaattat agaaagctac aatctacaaa ttgctatgta ctacagtcta

109741
ctaaatagta taatacttta ttttgcaaac tatatctctc agagtacaag gctccacagc

109801
tagtcttgca ccaaatatat gaggttcttg aatagtcatt ttctcaaagt tctcatctct

109861
ttacaaagca agttgagggg ggaagcagag agagcactct ggtgcttcca aaagcatcag

109921
ccatccacac tctgcctatt gaaaacacca aatctgagca tgtgtgtcat tgtccaggaa

109981
taaacaatca caaaaaggca tcaatgaggc ctataaaaac aagagcgcat gcaagaagat

110041
gggattgtta tgaaacagga gcacaaggct actaaaagag ggcaagccta aaggaaaagt

110101
caccagggtg agatggaaat agatatagga agaatagtga acggtggcaa ggaagtaaag

110161
gaatacaaaa gtaataaaat atccattgca ttagtccgtc cttgcattgc tgtaaagaaa

110221
tacctgagac tggataattt ataaagaaaa gggtttattt ggtttatggt tctgcaggct

110281
gtatgagaag catggtgcca gcatctgctc ctggtgaggc ctcaggaagc ttctattcat

110341
ggaggaaggt gaagggggag ctagcatatc acatggtgag agatggagtg agagagagag

110401
agaaagagag agaggagatg ccagtctttt aaataaccag atcttatgtg aactcagagt

110461
aagaactcac ttatcatgag gacagcatca agacattcat gaggaatctg accccatgac

110521
ccaaacacct cccactaggc ccacctccaa catgggcagt cacatttcaa cataagactt

110581
ggagaggaca gaacatccaa accatatcac ccacattgag ggagcaagga gcagactcca

110641
tactgcagaa cacacatggg aaacaaactt gagaagtttc cccagggcat agggtaagag

110701
gacgaggggc tggaaaaaga aaggtaatgg atatagagga cagagaatgg agttcgaaga

110761
tacatctaag aactttacat attcctaagg aacccacaaa gataaaacaa acagagcaag

110821
tatgaaagat gtaatagaag caaatgaccc tgcattgaaa atgatcaaag tatgcagatt

110881
ggaaaggctc acaaattcca ataaaaagaa ttgaaaacaa aaaaaaatgc tgcaataaca

110941
ttctttaaac tatattaatt gtaaggtttt tacaaaaata agtactcagg cagtagtaaa

111001
aagtttgcga ataaagaaac caaaattaaa ctctaacttt tcttatgtaa taccaaattc

111061
cagaacttgg aaacatatct gcatgcttta ccagggacca gattatgagg cagttattta

111121
agattagaaa agttctcttt cattggtaaa ggcaacagaa agatatattt tagaggtaga

111181
agctctctaa catagacact attctgccaa aaaaaaaaaa taagataaat gtaacaaaat

111241
aaaatgagct tcaaggtgta ttttggtcac tgagagatga ttcaaaagaa gactttgaac

111301
aatgagaatg ttaacattta aaagaatagg tggaattttt ccttactcag tttgttcaat

111361
aaaatcatgg gtccactgta acctgatata tcttgttgct taaagggaaa gcttggccct

111421
accttttctg ctttcttctg tgttcatggt gtagaaaatg tatttttgtt aaccaattat

111481
ttacttcaca cttgaggtag actttgttgc catgttggat ggctattttg ttaggtcaaa

111541
cagttttctg ccacatgcct atgtgatttt aaataatgta gccctcaccc tgagcttctg

111601
ctatagggac cacatgcttt gtggtaacca ggtgctgcca aaattggatg atagcaggct

111661
cctgacccat gcctgtcaag tcataggtgg ttaaggtcat gggagttgga gtcagactgt

111721
ctggttccaa atccaaggtc taccagttga ttttgacctt aattttctta ttctgtaaaa

111781
tgagtttatt gattgttccc actcagttcg tttgaggtga ggattaaatg agttaatacc

111841
tgtaactttt tgactggcac aagacacaat cctattacat gttctgaaaa aaaattctct

111901
acatgaacca aaggaatgaa ttctatttcc tccactgcta ctacaactca acacttctaa

111961
tcaccaaatg tgtggaggtt tttctacatc agtttgtcag acacctacta tgtgtcctat

112021
aattcagttc agttctgaca ccatctacat ggaaacaaca tccgatccca tggactaaaa

112081
gctcagtctc ataagactgt ctataatggc tcaagtgggt tcttcttgcc tgctgcacag

112141
aaaaaccaat acatcaaggc agtggtgttg cagtagagaa agcatttgat aatcacaagg

112201
ccagccaagt ggaagcatgg gagataattc ttaaatctgc ctccccaaga gctcaggggc

112261
tagggttttt aaggataatt tggcagacag gggactaggg aacgagtgct gctgatgagt

112321
tgtggatgaa atcataggag tatccaaact gtcttcgcat gctgagtcag tttctgggtg

112381
gaagtttctg cgtgggagtc aatttcttgg catgagtcac aggtccgggt ggagtcagtt

112441
agttgccaga atgcgaaagt ttaaaaatat ctcagagacc aatcttagat tttgacaata

112501
gtgattttat ctataggagc aagaggggaa gttaaaaatc ttgtgacctc tggctacatg

112561
attcttgagc agtaactatt atagaaaggt aagctaggga acaatgtctg gttatcattt

112621
aattacacct acatcttagc agaatttaag ttcttctcat aagcccaacc ttgtggactt

112681
tcattagtct tacaaaggca gtttcagtcc cccaccaagg agggcattag tttcaggtag

112741
ggactgttat catctttgtt ttaaagttaa aaaaggcagt tagcttgtga tgttagaaga

112801
aagatgtcag atttctctca ctgtcataat ttttgcaaag gtggtttcat ggccccactt

112861
gaaatgagaa tgggaagtcc aggttttcac ctgtgcttta gactgggtgg agataaatta

112921
aaggttcaca ggacctcctc ctcagatttg accatttgct agaatggttc acggaactca

112981
gaaaaacagt ttacttattt gattaccagt ttactttaaa aggaaattac aactcaggaa

113041
gagccagatg gaagagaggc atagggcaag gtatgtggga aggagcatga agcttccgtg

113101
cattcttggg ctcatcaccc tctcagcacc tccatgtgtt cagcaacctg gaagctcttc

113161
gaaaaatgtt cttaagccag gtgtggtggc tcacacctgt aatccccgca cattgggagg

113221
ctgaggtggg tggatcatct gaggtcagca gtttaagacc agcctggcca atgtggcgaa

113281
accccgtctt tactaaaaag agattagcca ggtgtggtgg cacatgcctg taatcctagc

113341
tacttgggag actgaggcag gagaattgct tgaactcagg aggcagaggt tgcagtaagc

113401
caagattgtg tcactgtact ctggcctagg tgacagagca ggactccgtc tccaaaaaaa

113461
aaaaaagaaa gaaaagaaaa agaaaaatgt tccttcagat ttttatgagg gcttcattgc

113521
atatacatgc ccctccctgg aggttggtct ggaggttggg ctgaaagttc caactctaac

113581
cacatggttg atttccatgg caacagccct gcttatcatt agggacttcc caaaagtcac

113641
ctcattaaca caaactctgg tgtgactgaa taacaaaaga tgctcctgtt acctttattg

113701
ctcttagaaa attccaaggg ctttaggggc tttgtgccaa aaacaaacac tatatatatc

113761
ttattataaa tcacactatc tcacattatt attatttaaa atgataagtc agtcaagctc

113821
tcttttcttg agaatttgat ttgggaaact tcgagaatga ggcaaggagc agtgggaata

113881
ggagtttaaa gtaagcatag aaagcataga aagaagctag ggaatagatt aaggttgcaa

113941
ggagggataa caaatggaga ttaggaaata gtggagactg tgattaagca gagcctgtca

114001
ttaggcattt ctgatataaa cccagatgct gtcatatcac ctcactgaat gcttgccctg

114061
aaacacttgt tttagtgcag ataaattcat cacctaagga tggcttatcc tttctatggc

114121
cattgaactt aagagctcca ctaaatagga taactccctt tatgcbggga aatctaccaa

114181
aattacctgt gtcagaaggg taagaaaaga gaatccagga tccagaatgg gattgaagtg

114241
atctcccatt ctttttgtga tatttagact gccttctgcc tctccaatcg acagaataaa

114301
gaccaaactt ctacccgggt gggtagggct tatcctgagg atggagactt tctaagtata

114361
gatggtcaag aaactggtgc acatttaagt tagacgcatc tctaaattgt ctgggcttag

114421
actattctaa gaatgaataa ttatgaaaat tgaggcagct cagagactca ttttctaaga

114481
tttcaatata tgattagcaa agtgctatag aaaaaaataa aatggcacag tttggcagtt

114541
ggcatcttgt atctttctgt cccaggtctt tcttgtgctt gtaattcttt cattgataaa

114601
gaactcagct atctatccag gcgtgatggc tcatgcctgt tatctcagca ctttgggagg

114661
ctgaggcggg aggatcactt gaggtcagga gttcgagacc agcctggcca ccatggtgaa

114721
acccacatgg tgaaacatct gtactaaaaa tacaaaagtt agcbgggtgt ggtggtggga

114781
gcctgcagtc tgagctactc aggaggctga ggcaggagaa ttcctcgaac ctgggacttg

114841
gaggttgcag agagccaaga ttgcgccact gcactccagc ctgggtgaca gagcaagact

114901
ccatctcaaa aaaaaaaaaa aaaaggattc agcaatgtgt ggttcttttg aatctatggt

114961
atgtattagc acatcacagc agagcagagg ttctcaacaa ttgattttat tccccagggg

115021
acatttggca atgtctggag acaattttgg aacttagagg ctgatgctat tttggaactt

115081
agaggcttag atgctattgg tgttgtgggc agatgacaag agagattgca aacgttctcc

115141
aattcagaag gcagcctcca caaaaagaat tattcagtcc aaagtgttaa tagtgctgtt

115201
attgagaaac catgccctag agaagcagcc tagaactttg agtttttcct tttttttttt

115261
tcaatcaact aatgagaata aatgtggagg agacgggcaa aaatgtcagc agccccgtat

115321
ggttttcaaa atcatttcag atatttgcta ttcaccagtg tcagccaatg tgtttatttt

115381
tgaaaggtca gaaatttcat agggccagat tactaaaatg gttattatta tttttttgtt

115441
ttcaagagct tatgttagtt atctagtata gagaagtcta ccatagagat ccctttgttc

115501
tgagtactgg actttttcac ttaccaaaac tctcctactc tatacgttct tcaccgtgat

115561
aatccaagaa gtctgaatcc tccccatggc tctcccctgt ttccatcccc agtcggtggg

115621
tttcccacag gtctccagtg tgctttggaa gtaggaactc ctaacagatt cacagtttga

115681
acatggtagt cctctgagct gttcagtatt ttaaatctct ctgcagttag ttataatcat

115741
tcaactcttt tagtcattct tctaatgtca gtatagataa ctaaaagatt gtaatattag

115801
aagacctatt tcccagagac cacaaagaca atctcatgga agtcccactg tagtaaatag

115861
agtctatttt ctacccagca tctggtagag taattcagac atgtgttttg acagtttgcc

115921
tgaaagtaac ttgacaaata attttactaa agaatcctag aaagtcaatg gcaacatttt

115981
gttcattcta agttgttcaa gccacgtcct tagatgtggt tgattcaaat ttcttcagaa

116041
ctggaaaagc acaagagaat tagtattcca gtaataagga atcatggatt gtggcagtct

116101
ttttaaaaca taaactagtt tagcacataa gtggtggcct agtacatttt aaagtggagt

116161
ccaagggaag tttcttgaat tgctgtagtt cttatggtgt tctgctgaag ccgtgtagat

116221
cttatggtgt tctgctgaag ccgtgtagat attgatcatg ctgcctccca ccaccacccc

116281
cttcattcca gatctgctca aagacaactt agaaggtcct atcctggtct cctgtctgaa

116341
acatatactt tctctcctcc cgcccccagc ctgcccatac tattccaatc cttctctacc

116401
tattattcct ttgttttgtt ttcaatataa aaatcttatc tatttcttta tacgttaatc

116461
atctatcact ccccacacac tacaatgtgt gcattcattc cctgagtaac tgaaacctag

116521
aggcccggga gtcatttttg aaacttcctt tccttggctt tctcctctaa ctgctcttcc

116581
aattcatcgg ctggatttga ctattctaat tccaaatctg tctggaactc gtgtacctct

116641
cgcagtgtcc actgcbgttg ttctggtctg gggcacaatc gacactcatg ctcaccgaac

116701
tgcagcagcc cccttcctgc tgcttatttt gaccacacct ctttttgaac ctattctgta

116761
caaaggagct ggaaagagtc agtaaaaata cagagcatag tgttcattgc cttgcttgga

116821
caggacctgc catatgtgtc ttctctatag tattggctga atgcataaac agcgagaaat

116881
aaatgtgtag agagtaaatt gatagaaagc tgccctcagt catctcccat ggagagggct

116941
agtgatgact ggcgaaggtc acagagctac tatgtgttag attttggact aaaatccagt

117001
ttttctgaga acggtcaaga gtttatttat agaaaacatg ctgctttatc tcttaattcc

117061
ttctcactcc ctgcaaatta gtggcatttt agtttactta aatgcacaat tatttttaat

117121
tttgattgaa aaattaatac tcatttactt ctgaaaacta tttctttacc gaagagcata

117181
gagaaataag ggagtaattt atcaacctac cataggtgga atttttactt tcatctttat

117241
actttcttct tcattattgt tttttttaaa aaacgtaagt atgcatttat ttttataatc

117301
aggaaatatg tgaagttata taaatgtgta atgaatttca ttactgggaa ctaactgctg

117361
gtgatatttt acacttgatt ttagccaaaa ggccgagaag cgatgctggt gatattctaa

117421
tgtactataa cttattctaa tatttcatgg gatttatttg caattagtgt gatataaatt

117481
tccataatgt atggaaagat atattagaag atgctaacca tgggcttaag aaagtagatt

117541
tcataatttg aaacacggcc cacacaatta ataaatataa gacatttggc actctacttc

117601
taatctcttg atttttttta tagcaactgt ctttaagaac cccagcatat tcatggattt

117661
tttagaaacc taattatttc ctagaaaaat cctttgaaaa aggaaaatta tatttgacag

117721
ttttctaaag attttctgtg cagaagttgt atctggatat acatataaag ccctgaagta

117781
atctatacat tttatcgctg gtcttcagat atgttggcag agtcgctcgt gaaatatatg

117841
cttgaaatta atgtaattac tctgacattt gttattttaa taagcattct tagctaatac

117901
atagaggaat acattaaagg aactctaaca ccaaaattat cctttcttaa ttaaataaga

117961
aggactgcaa ttatttaaaa agtgtatgtc aaatctaagt tgccttcaaa tgtaatttaa

118021
ttttctgtta cttacatttt aaaatggcca tagctttttt cgttgttcat ctttcttaat

118081
tctttaggca ctacttaccc cccaactcca gcaaccaaaa ttaatcctaa tttgcatcac

118141
aataatttaa aatagatcaa agaaccaatt tcatagccta attcaaaagc atcatgcgac

118201
caatatgtag tattaataaa acatatttct ggttttgcca atccaatttt ttttttaatt

118261
aagtgcttaa cacagtgccc agcacagaaa aagcacttga tacatgtttg gtaatgtctt

118321
tgtgactgtc atttttacta atgttgtata ttggtactac taaagtctaa tgggatgctt

118381
gtattatggt gtgataatat agttaggatg accacttgtc atggctggcc tgtgagaatc

118441
ctgtttaata tctattgttc cagttttctc caacttaaca ttttagcact caaaagtatg

118501
tgatgtggag gataaatttt atggtcgcca atcctttatt gtaaagaatc gtgatgcaaa

118561
ggctccagtg tagtcatcac tcatctcttg atttaggcat ctaagctatc caggcatcat

118621
catgggggtg agcagcctga atgacagtaa gctttccaag tatggggaca tgcacttaag

118681
ataggtatag ttattccagt gccaatctcc tcttacctgc tgtatgtcaa gaatcaggca

118741
acatttagga aatgaaacca caagtctttg tctctttttt taccctttat ctcaaaatgg

118801
tttttacttg ggatttgttt ttttgttttt tgttttttgt tttttttttt gagacggagt

118861
gccgctctgt cgcccaggct ggagtgcagt ggcgcgacct cggctcactg caagctctgc

118921
ctcccaggtt cacaccattc tcctgcctca cctcccgggt agcbgggact acaggcgccc

118981
gccactacgc ctggctaatt ttttgtattt ttagtagaga cagggtttca ctgtgttagc

119041
caggatgatc tcaatctcct gacctcatga tccacccgcc tcggcctccc aaagtgctgg

119101
gattacaggt gtgagccacg gtgcctggcc tttagttgag atttgattat gaatgaaaat

119161
gtaaagaaat ttgctagatg tgtccatctt ttcatgtggc agacaatatg gactagatat

119221
atggtggtca aaattatgtt tgtgggtata gcctaatagc ctaaaccaat gacacttatg

119281
tggcagtttt atttatttat tttttctttt taagacaggg cctcactctg ttgcccagtc

119341
tggaatgcag tggtgcaatc tcagctcact gaaacctccg cctcctgggt tcaaatgatc

119401
ctcctgccta aacctcctga gtagctgaga ttacaggcat gagccaccat gcccaactaa

119461
tttttgtatt tttagtagag atggtgcttt accatgttgg ctaggcttgt tttaactcct

119521
gacctcaagt gatccacctg ccttggcctc ccaaaatgct gggatagcag gcgtgagcca

119581
ctacgcccag cctcaccctg gactttatga caatgccaaa tatatgcact gtgtcaaaaa

119641
cagtcctctt cactgtcctc cagtagaaaa agctcaataa tgggtctaca aactcctgga

119701
tttagtccag gctatgtaat ttgtggaact tagtgccaaa agtagggtcc tttgttcaaa

119761
aattattaag aatttccaga tggcaacagt ggaacagtca atgaagcaca ggatccttct

119821
gtccccaagg tcctgaacaa ctgcagaaac cttgtgcccg tgcattcatc cctccttctt

119881
ggatccttta cctgttgatc tccttcgttt tctttccaga caacaattat ggacaactta

119941
ttattaatat atgtgagcca ctgtgttcac tatcggaaat aaaaatatgc ttataaggta

120001
gtcccaaatc tttttttttt tttttttttt tttttgagag acagtctcgc tctattgccc

120061
aggctggagt gcagtggtgc gatctcggct cactgcactc tccacctccc gggttcaagt

120121
gattctcctc ccgcagcctc ctgagtagct aggattacag gcgtgagcca ccactcccgg

120181
ctaatttttt gtatttttag tagagacagg gtttcatgat agtggccagg ctggtttcga

120241
actcctgacc tcatgatccg cctgccttgg cctcccaagg tgctgggatt acaggagtga

120301
gccactgtgc ctggccccag atcttagatt ttggtgatta aggacttcac gaagtagatg

120361
aaataacacc cagaatttgg ctggtttatt ttctccttaa gatgctcagc tgtgattttc

120421
tgtatattag tctcaagctg caaattctct attccaggat cttatgatct gtgtcctaac

120481
tacatattat agggccccag tggtccctat gcctctggtt ctattgtcat cacacacttc

120541
ctgtttcatt cctatagaca gatttattca tgactaggga acagattatg ctagtaaagg

120601
tgttggttaa catgagttta aggcaagaac ttaaacgtaa atatctctag ggattggaca

120661
ggcaatatgc cttaaatagt aaagctatca ggtagggatt gactgcatgc ctgcagagga

120721
aactgctgcc tatttagcca cagaagatta ttgccatgta aaaatgtgag tatggtttgt

120781
cacatatttt taaagaaaag tcagaaatcc aaaaatttgt atgaaatttt taaacatttt

120841
atattgtcaa ttcaattttt aaaaagactc aatataggca gagaaaaata actacagccc

120901
aaggttaagc caagaagtat tgtttttcta ctttttcttc gtagtcagat ttgttcagat

120961
ataattcaga tgtaataaat aaacccttta agttctatga gttttaacaa acacctacat

121021
tagtgtgaca atcactgtag acaagatata gaataattct ctcgtctccc ctccaaaatt

121081
ctctcaagcc tctttgtggt taattctcct agctcctgac aatcgctaat aaatttcctg

121141
tctatagttt tgccttttca agagtgtcaa ataaatggaa cactactgta tgtagccttt

121201
tgagacaggc ttctttcact gagcacaaat aatttgactt attcacgttg ttatatgtat

121261
ttagattgtt tctatctaat tttcaaaggt tttttccttc ctttcttctc ctttcctccc

121321
tccttccttc ctttcttttt ttcttcttcc tccttttatt ctgccttttt tctctccttc

121381
caactttccc gcttttttag atatcacatg tacagaagta gattaatctt gatgtttatt

121441
tcataacata ctctcatttg ggcccatgca tggcttgtat ttcaatagct ctattgagat

121501
aaaactcata tacattcaca tggagaaaca gccctgtgga gggaaagaaa ttgatatgca

121561
gtaaactaca catactcatt tacaacttga aaagtttgcc atatgtatac acaatgaaac

121621
catcaacact ttcaaggtaa taacatatct cagtttcctt gtgtctttat gttattcttc

121681
cctccttcca tctgatctgc tttgtgtcac tgcattttct agaattttat gtaaattaaa

121741
tcatatagca tgtgctcttt tttttgtctg gcttctttca tgcagcacaa ttattttgcc

121801
attcatatca gtttttgtgt gtatcaatag ttcattctgt attattacaa attagcattc

121861
aattacatga atacattgca atttattcat ttgtgaatgg acattgcatt atttccagtt

121921
ttggctgtga caaagattca tgtggaagtc tgtataggga catatgcttt catttctctt

121981
gggtaaatgt cttagagtag aatgcctaag tcatatggta gatgtatgtt taacttttaa

122041
agaaattgcc aaattgttgt ccaaagtgtg taccatttta cattcctggc agcagtgtat

122101
gagagttcta gttcttcacc atcccccttc caacacttgc tatagtcagt cttgcaattt

122161
tagccatttt aataaatgtg tagtgatatc tcactgttgt tttaatttgc atttccctag

122221
tgtctagtta tgttgtgtct ttacttttgt ttatttgcta tcattatctt ccttggtcaa

122281
atatctgttt aataattgat acatttttta ttggactgtt tgttttctta ttagtaactt

122341
tggagagtgc tatatatatt ctggatacaa atcctttaac aaatgtatga tttgcaaata

122401
ttttctccca gtctgtgatt gtcttttcat tctcctagca gtcttttgaa gagcagatgc

122461
tcttaatttt ataaagttca ctttatgttt ttttttattt tgtggattgg acatttggtg

122521
ttatatctaa aaaaaaatct gcctaaccca tagccttatg tgttttcttc tagaagtttt

122581
atagttttag gttttacatt tgggtctatg gtccattttg agttaatttt tgtatatggt

122641
ataagatgca gattgaagat ttttttttaa tatgtggaaa actgattgtt ccagcactat

122701
ttattgaaaa gactaatttc tccattaaat tgtctttgta cctttgttgt gaatcatttg

122761
cctatatatg tgtgagtcta tttctgaatt ctcttttctg tttcagtgat tcatctatgt

122821
tgatgccaat gctacactgt cctgataact gtagttaata aagtcttaaa gttaggtagt

122881
aaaagtctgc tattttcttc cttttcaagg ttgcattttc ctattccaag taatttgcat

122941
taatcaaaaa gtacatggaa aatgtgtatt ataacaaaag gtatggaatt ttaaaatttt

123001
caaaattctt ttgcatcaaa gtaaatgtgt actaacttgt tataatatgt gtgaacagga

123061
gctagtttga ggcactaaaa aggataaatc atcaatttaa aaacagcccc tatcagagca

123121
acatgaattc tgataaaatt gaagcaagaa caaatatcaa atttatcgtg aagcgtgggt

123181
gaaaaaaggg tgaaatcatt gatgctttat gaaaaattta tggggaaaat gtcacattat

123241
caaacagata actcatttta agaacagatg atatgatgtt gaagtcgaag cccacagcag

123301
cagaccatcc acattaattg ataggaaaaa aattcatctt gtttgtgtct taattgaaga

123361
gcactgatga ttaacagcac aagtaatagc cacaaccata tacacctcaa ctggctcagc

123421
ttacacaatt ctgactgaaa aattaaaatt ggccaaagtt tccactctat gggtgccaaa

123481
accattgtgc ccagatcagc tgcaggcaag agtagagctt ttgacggaaa ttttaaacaa

123541
gtgggatcaa ggtccagaaa gatttcttaa aagaacatta ataggagatg aaacatggat

123601
tatcagtatg accctgaagc caaagcacaa tcaaaacaat ggctaccaag aggtggaagt

123661
ggcccagtca aaataagagc agaccagtca agagcaaaga tcatggcaac agttttttgg

123721
atgttcaagg cacttttctt gactttctgg agggtcaaag aacaataata tctctcatta

123781
tgggagtgtt ttgagaaagt caaagcgtta gcagaaaaac gtctggcaaa gcctcaccac

123841
agagtccttc tccaccatga caatgttcct gttcattgtc acgaaacaag ctctcacgaa

123901
ataaagctct aattttgcaa gaatttcaat gggaaatcat taggcagcca ccttacagtc

123961
ttgatttggt ttcttctgac tttttgtttt ctaatcttaa aataatcttt aaggggcacc

124021
catttttcct tagttaataa tgtaaaaaag actgcattga cataattcaa ttcccagggt

124081
cttcatttct taaggaatgg actatttggc cggtatcatt gcttacaaaa gtgtcttaaa

124141
cttgatggag cttatattga gaaataaagt ttatattttt cattttaatc ttttaattat

124201
atttttccac aaaatttttg aagtcctctc acatatataa atttttggaa tcagcttatc

124261
aagtcatgta catttactgc tatatcacac tctgttttgt gaatattcca aaattatagt

124321
ctatgattta tattgttgtg actattgcat aatttacata tcaatgtact gatgatcata

124381
ttttgcaata tttttgttat tgttattcta ttatgaacag tgctactaat ataaatagta

124441
tttgccacct catacacagg tgcaagttta ttgtaatagt cttagtatta aattttctga

124501
gtcatagttt agcaaaagct caacttttca caggatattg ctggattgtt ctccaaagta

124561
gctaagttat actcctatta gccgtatatg agagattcta atcatcttca ttcttcaaca

124621
tttactattt tcagacttac taattttgcc agaaaaaata catgacaatt catacccgta

124681
cctgtagtgg tcttgatttc catttactca gaagacattg gacttttctt cttatgttta

124741
tgggctatat tttcccttct tttatgatat tactgttcat gtttttgctc atcttattgg

124801
gttatgggcc attttatttt atttttattt tttatttatt tatttttttt tgagatggag

124861
tctcgccccg tcctgcagac tggagtgcag tggcactatc tcgactcact gcaacctcca

124921
atgggccatt ttatatccta acatatgaag tatctgttca aatcttttac catttttttc

124981
ctgtaggtgt gcttgtcctt ttcttgttat aataaaacag ttctttattt ttgatactaa

125041
tcttttagaa agtgttctgt tgggcbgggc atggtggttc atgcctgtaa tcccactctg

125101
ggaggctgag gtgggtggat tacctgaggt caggagttcg agaccaacct ggccaacatg

125161
gtgaaactcc atctctactg aaaatacaaa aattagcccg gtgtggtggc gggtgcctgt

125221
aatcccagct actcgggagg ctgaggcagg aaaattgctt gaacccagga ggtggaggtt

125281
gcagtgagct gagagcatgc cactgcactc tagcctgggt gacagagtga gactccatct

125341
caaaaaaaaa aaaaaaaaag agagagaaaa gaaaatgctc tgtcagtggc aaatatctct

125401
tacttttttt ttagttttct ttgaaacctc ttttaatgaa tagaaatttt tttattttaa

125461
tgtagtttaa ttcatctatt tttctttttt aattgtcttc agtttcttta gtcttgtttt

125521
cataatcttc tggatatgag tcttgcaaaa catcttttgt taattttctc atggtttttg

125581
ttataatagt atttagagtt attttatata tttatggtta atataaatca aattgcatgt

125641
tgttcttgct ctaaattaca gattcaataa tttgcaacaa aaccttatct ctttgtaagt

125701
ccttaagtta attaagtact ctggatatct tcacatataa atacttgtat cagctgtctt

125761
ctctcttact actccaatta aaatccagta tctagaatag ggaaaaacca ggtgaacatc

125821
acccttacag agatttattt taagacataa tttagggtgt gctccatact gccttggcta

125881
tgtactagtc tatatattct agaagggtca tatatgtgca caaattgatt tgtgtagcca

125941
aaagctgctc cagtataaat gtgccaccag gatccatttc aaaacattgc ttcctcttgc

126001
caaggttagt gcagctatgc ttgctatcac tcaagtaacc agagaatgcc agcgtccgta

126061
ctctcaaaaa gacagccttt tctgcaccat tacaattggt gtcttttgtc cctttctttt

126121
cactgatgga aatctttttt atcattccaa tcaaagatca ctaccttcct aggagaagtt

126181
tcaatagaaa gaaaaaaatg ttatacttcc tcagaaaaat agcactttct tcatatagca

126241
agttttactt tcagaaaagt tgagaaaata aatactatgc ccccaggttt cccgttattg

126301
gagattgatt gctatgttga atgtgctata gctttgctgc ttaaacccaa acgccaagtg

126361
caggagtatc ttctttacta acgcatttaa tttaccaagc acacttagtg gctggtattt

126421
cttacctttc taagggtgca ctcacttaca ctgccctcaa tatatgtaat taggataaaa

126481
ccatagaatg gaaggcatta aaaatgaggc aggaaagcac aggcagagtg ggatgaagcc

126541
agctttgctc tgaataggac ttatatgatc agtttagttt tattccaaac atgaacccca

126601
aattcaaccc ctttgacctg agtactccgt cccttaaatg gcaaactaaa cattcgtgaa

126661
aatttaatgg tgaggaaatg agtaccttct taagtttcag atggtgaaat ggcaccaggg

126721
gagcactttc agtggcaggc agaagtgtgt ggatgtgcta gatcaaacct gaaatatttg

126781
ttccttcatc ctgcagtccc tctccaaact agccagccac tgagaccttc tgacaggaca

126841
cccccaggat gtcacccaaa aaaggtattt acaaaatcaa gactgtctgt aggacactat

126901
gtctttctga gaggtataaa ggtatttgaa aactttggaa agtttgtttt acaatttttg

126961
ttccctcttt tggggctttc cctttttcat ttttttctgt gggtagtttc cctttgtttc

127021
ctgagaaatt gagaagggtt taatatctct ccaccttctt ctcttttatg gatgaatgat

127081
ttcaccaact ggtaagtgct aaaactgacc tcgctttcac tcagaaagac aatggaggaa

127141
aggaaaatgc actgagattt cagcatagca actcaaatgc gggctttatt ccacagcagt

127201
gacctattgt cagattggtg tgtgagacag tttttgaaag gggatgtgtt ctgcttccgt

127261
ttatgagtta agcaaagttc taaattaagt tgagaagagg aagcaggtaa agtcagggat

127321
agcagagaaa ggagacatca aaccctattg ttgtaggata tttatgtgaa ggaatgagca

127381
acgtgataaa acacattttt gcttgcbgtg acttgccata gggtgcattt tcagtactgt

127441
gtggataatg tgtggcatgt tcattcatca gtcattctgt gacatttatg tagcttacac

127501
ttggatctat tttcaacaac atttcagttc cctaaagaca aactggcaga attttcaaat

127561
aggaaaaacc tggacacaca catttgcttt tctgtataga ctgtctagtc cagataatct

127621
tgctatcagt cattttgtta gcttactcat ttaatcttag aatggaaagt ggaaacagag

127681
acctcattta gagataatct agtaaagcca tccagcttca ggctcatatc ttgggaatct

127741
gagcagtacc ctatttaata tgctcatttt attaacttta aacacctgga gaacatcatt

127801
attgagaagg tcattgcttt tgaaaaaaca aaaacaaaac aaccacttct tatgaggctc

127861
tacacatctt tccaaagaag ctattggaaa tggcccaaac tttcatatta actcttaaca

127921
gggtggcgtg gtttttcatt agtaagaaca ggattcaaat cttatggaag atggtagatt

127981
tcaacacctt agcatttttc tcaaccctgg gatcttcaag ttcctcaggc tatttaggta

128041
gttatagtgc tggcaaactt tttaagtgcc cagtagtttt tacaaaaact tgtaataaat

128101
ctgctcaggc tatcttaatt gccaaccatc tcattaagca agtcaaatta gaatggatta

128161
ttcctgctgt ttattagtgc tgcatattat ttatcattta ttaaccttat tgtgctcaca

128221
tagcaggtat tttaaagttt aacagcttta ttttaattat gaatgtaata tatgctgttg

128281
cagaaaatat gtaaacttta gagaaaatgt actaaatgat gcactgatga aaatacagaa

128341
tcccaccaca aaaatattat tatcaacatt tgggtattct cttccaaact ttttatatga

128401
gagttatgtt tggtttatac ataataaaat gggtaaaaat caataaatag aaagcaaatg

128461
tttttaaggc agtacttggg cttcataaga atggaaaaaa atgatagact tgcctggtgt

128521
ggtttgcata atgtcacaga atcataacaa tagctccatt attgagtgtc tattatgtgc

128581
caggttctgt acaatgttca gtgatgcgtc actgtgatga ctagaggtaa aggaaagata

128641
agtgatgcct tactatgatg acttccaaca agctatgaag ggacagaaca agcctttttt

128701
tttaactttt attttaggct tgggagtacg tatgaaagtt tgttacatag gtaaacatgt

128761
gtcacagggg tttgttgtgc atattatttc acacccaggt acctatgtcc agaacccaat

128821
agtttagttt tcttttctcc tcccctccct cattctatcc tcccccctca catagacccc

128881
agggtctgtt gtttccttct ttgttttcat aagttcttat cattatcata cttataaatg

128941
agaacgtggt atttggttgt ctgtttctgc attagttggc taaggataat gtcttccagc

129001
tccatccacg ttcccacata agatataatc tcgttctttt tttatggctg catggtattt

129061
catggtgtat tttatatata tagatatata gatatatata taaatatata tagatatata

129121
tataaatata tataggtata tatatgtcac atatatatat cacatataca aggatatgtc

129181
ctctagctcc atccatgttc ccacataaga cataatctcg ttcttgtttt atggctgcgt

129241
ggtatttcat ggtgtatttt atatatatat atctatataa aaatatatag atatatatat

129301
cacatatata tagcacatgt atctatatca catatatata tatatcacat tttctttatc

129361
cagttgggac agaacaagtc aactggcaag tccattgctc agcttgttga aatactctgc

129421
acagaatgca aggaaaaact gttttcatga ggtagcccat gaagcgatga agcaaggcaa

129481
atttatctgc ctggataacc tcctgtatgc tgttttcact ccatggagag tcaacacaac

129541
agacttctga gttgtattat cgagctcctt caacagggca ttgctgtaag atcctagatc

129601
ccacactcca tggtgtgatg ttttagccaa gtctggaagt agcacaggcc ctaaaatctc

129661
atgattgcag gttgtcaact ctgctgtagg cttgccactt caagggcaag tggttggttg

129721
gggctgggat ttgggcagag ccatagaaag aaagggaaca ttcaagggaa tttgatgatg

129781
tgcatgatgt ctctgtctga tacaaaaaga aaaaaaaact ctaaaaacat ttgatacata

129841
gaaatactag tatttggtga gattgaatgt gggaagatga gggataagaa ggtattaaga

129901
atgactccca agtttctgac ttggtcagtt gagtagaagg gaaattttta tttttatttt

129961
tatttttaaa atttcagtaa gtttttaggg aacaggtggt gtttggttac atgaataagt

130021
tctttagtgg tgatttctga gattttggtg cacctatcac ctaagcaggg tacactatgc

130081
ccaatgtgta gtctcttatc cctcaccccc catcctttcc cttgactccc caaagtccat

130141
tgtaacattc ttatgccttt gtgtcctcat aatttagctc ccaattgtga gtgagaacat

130201
atgatgtttg gttttccact cccgagttgc ttcacttaca ataatagtct ccaattcatg

130261
ccaacatcta ttattttttg attttttgat catgaccatt gttgtaggag ggaggtggta

130321
tcccattatg gttttgattt gtatttccct gataattagt gatgctgaac atctttccat

130381
atacttgttg gccatttgta tatctgagta gaaggtaatt ctaataaata aaacaggaag

130441
gcagcagaaa gaggtttgtt tgggatatgg cttgattatt tgcaagatat ttgctgtagc

130501
ttaggagaaa ggtggatgtt ggtgatactg attttgtcat tatctgtgag ttaaagtttc

130561
taaaatcacg tggcttccta gggaaagcat atagaatgac aagggaagat ggctagatgg

130621
ctagtaatgg caccctgaac aacttcagca tttagaggtg ggtggaggag gataagccca

130681
tggaagaaac agaaaggatg ggccagcgag atgagaggag aagctaaggg agtagacagt

130741
taccagaggg aaggtgggat cagttaagaa ccttagtatg ttgcaaagaa ataacctgca

130801
atgcggacca acccggggaa cgtctgtaaa aatgatgaca attcttaatt gtaatttaaa

130861
atgtaattgt attgagagct ctctctgtct ttgtctcatc ataatttgaa gcagattaac

130921
tacatattag ctagaaaaag ccctttgaaa ttttccttca atgtatcaat agattctatg

130981
actttttgta agtagaaact gcctattggt aaaatagcac ttaattgaga taatgcttgt

131041
gaaagccatt tctaaacttt gaattgacat acaaaataaa ggtggcaatc atcaccatgt

131101
tgctatactg tctttggcca tataaaattt ttttcaacaa tacaaagata agccttgtac

131161
aaattcttca aaattctaaa tttgtggtac ttgaataatg ttttactata tataaagatg

131221
aatagatagc atttcctaca ataaataaat aatttatata tcaatgtgtt gggattataa

131281
attctcatag aaattcactt tattaattca ttcattcatc tgatcacagt tcattcagca

131341
aataatttgt tttgttcttt ttaagtgctc tgggaagaag gtattgtgac agagtccctt

131401
ctctcaaagc gtttatagat tcatgtgttt ggggaaagta cagaacaatt attgaaataa

131461
aaccagagtc aggcacattg ctatgccagc tataaagagc ctatgaaaat taggaacatt

131521
gacacatttg ttcctaacct ggtttgtgct ttcaggattc ctctgaagtg gcagcactcc

131581
ttgggtttga aatgttcgtc agtaatgact gatggacatc aacaggtgaa tagacacaca

131641
aaaaacctat gaaacttaca taccataggt tactattcaa caataaaaag aaaaactgtt

131701
gatacatcta acaatgtaga tgaatctcaa aagcattatg ctattccttt ggctgataaa

131761
atggtgacac tcctttattt ctctttcttt catcccactt ttaaaatcag ccttagtata

131821
ctttaggcac aatatactat atacatttaa aatgacaatt tgacaagttt tgacaaatgt

131881
atatacatta taaaaatcat gataaagatt tccgccgcct caaaatgttt cctcatgcct

131941
tcttggaata aatccacaca ttccttcctt ctctacaccc caccacccat atactctacc

132001
tctagaccca agcaattgct agtctgcttt ttgtcagcgt aaattagttt gcattttcta

132061
gaatttcata ttaatggaaa tgtacagtaa gtactctttt gtgcctgact tcttacattt

132121
agtatagtgc ttttaagatt tatccaaatt gttgggtgta tcaataattt gtttcttttt

132181
attgctgagt agtattctat tgtatacgtg gttcacagtt tatccattca ccagttaatg

132241
gacattccag ttgttttata tttggggctg ttatgaataa agctgatgtg aacatttgaa

132301
tagaagtctg ttgtgaatgt ttggattgga attgcbgggt tgtacagtaa gtgtttgatt

132361
aacttcataa gaaactgcca aatgattttc caaagtggct acatataatt ttgcattttc

132421
accagcagtg tatgagattt ccagttgatc ctcatcctca ttcaaaacct ggaattaaga

132481
gtgaatcttt taaattttag ccttttgaga aaatgtgtag tggtacttca ttgtagtttt

132541
agttcgcact tctctaatga ctaatgatgt ttaacatgct tttatatctt cttttgtctc

132601
catctattct ttgttcttca ttctcttttc ttcctttaga gtaagtattt tttattttat

132661
tccattttca ctattggtat attatctata aattctttgt tgttgttcca ttttagtggg

132721
tttacaatat aaatctttaa cttatcacag tctgtcatca aataatggta taccccttac

132781
atatgtttta ggaaccttac agtggtaaaa atatcagttc cccatcctgt acttgttgct

132841
attgttttca tgcattttat tctgtatata ttataaactc tacaatctat cattattact

132901
ttttgtttaa atattaaatt ctttaaaaga gatttttaaa aataagaaaa tagtctttca

132961
tattttctca tgtatttgcc atttttattg tttttttttt cttccatatt tgagatccaa

133021
atttctatct ggtatacttt tccttctgcc tgaataacta cctttagtat ttttttgtag

133081
tacagatctg ttggcaatga ttatctgaac ttctgtatgt ctgaaaaagc ctttagctaa

133141
tttttgaaag ttttttgatg gacatatgat atggtttggc cctgtgtctc catctaaatc

133201
ttatcttgaa ttgtaatccc catgatcccc atgtgtcaag ggtgggacca ggtggaggta

133261
attggatcat gagggccgtt cgccccatgc tgttctccta ataatgagtg agtctcatga

133321
gatccgatgg ttttataagt gtctgacatt tcccctgctt gcacttctcc tttctgccac

133381
cttgtgaagc aggtgcctgt ttccccttca ccttctgcca tgattgtaag tttcatgagg

133441
tctccccagc cttgctgaac tgttagtcaa ttaaacctct ttcctttata aattacccag

133501
tctcaggtat ttcttcatag cagcatgaga atggactaac acggtacata caattacagg

133561
ttgctagtcc cttttttccc ttcagtgctt taaggatttc actcttccat agtttctgat

133621
gagtagtctg accattccta actttgtgcc attattttct catttttttc tgactctccc

133681
ttctgggact ccaattacaa atatcccaga cttcctaact ttggcaggtc aagagatcga

133741
gaccatcctg gtcaacatgg tgaaacccag tctctactaa atatacaaaa aattagccag

133801
gcatggtggt gggcgcctgt agtcccagct acttgtaagg ctgaggcagg agaatggctt

133861
gaacccggga gggggagcct gcagtgagct gagatcgcgc cactgcactc cagcccgggc

133921
gacagaccga gaatccgtat caaaaaaaaa aaatcattca aaagattact gatgcttgtt

133981
tcattttttt ttaatttttc aactggtaat taatttatta aaatagttga cttatacgtc

134041
tacaatggtg acttccatct caactcctgg ctcaatactg atggaagtaa tctgcttaac

134101
aatctcagaa ggactgagca agtcaatgag tcgcttgtgg attctcatct ggaaatgatc

134161
ccatggctta gaaccttcac cacatggagt tttttcttgt agtgattctc aaagtcttag

134221
taggcatttg aactggtctt ttcactttga gattcttttc ctttgctcct ctgatcaagt

134281
cagcacacac cttcgccagg gattttacat tgcagcttgt tagagtgatt cgaattcggt

134341
gaattgccat cttcggctcc gtgggtgttt ttccggtatc cttaaaagcc atcactgctg

134401
cgcggcttcc tgacctactt gttccggcaa gagtgaacag tggtgagtca ggagcaggtg

134461
cgggcggatc agagctccac aacacctacg accacctctt cttcaaagag gtgtttcatg

134521
ttttaaaatc ttaatttcct tctgtttcat tttggataaa atctgtcttc aagtttggtg

134581
cctttttttt tgggccaata tctaatctaa agttcatcct atccagtatg tttctcattt

134641
caaatattgt attttctatc tgcagagttt gatttgtatt tgaaaacgtt ttttaatctt

134701
tctcattgtc ttaaacattt ggagtatact tataataatt gttttactgt tgttatctgt

134761
tacttctatc atctatgaaa ttactatatc tgtttctatt gattgatttg attactattc

134821
tggttgggag gcaatatttt ccctacttct ttgcttactt ggtaattttt ttatcaatga

134881
aaatttataa aagtgaactt catttacaat tggatataat gaattttaca tttttgtgtc

134941
ctggattttt ctgtattcct ttaaatattg ttggatttct tttttttccc ccctccggga

135001
tgcagataag tttcttggaa ttagctggat gcttttgaga tttgctttta agatttgtta

135061
gggtgaattc agagcagggc tactttgatc taggaaatag ccctctgaag ggtctcatgt

135121
tctgtgagat aggaggtctt tctcctctga ctggttggta gcctaagcta ttcctgattc

135181
ttgtaaggtc tggacactgt tctgcatact cttttctgat agttctttcc ctggccttag

135241
tagttaccac acatctatgc acatagcggt attcagccaa agtttgaaag gattcaaaga

135301
tctccagagc tctctctgta tcactgtttc tgttattcta tcccacaaat tctaagtgtg

135361
tgaaactccc tgaaatcaga actatgtctc ctcaactcag tgagaccaca agccactgtt

135421
tgggtttccc ctgcccatgt tgcagcctag aaactctcct caggcaaaaa gatcaggcaa

135481
catcggggtc atctcatttc cttccctttc agagatcact gtaattgcct attgaacaat

135541
gcctgaagaa agatgtttca tatattttgt ctggctttct agttgcttaa ggtaagaagg

135601
taaatgcatt cctagttact gcattgtggc tgggagcaga attccaatac tgtttttttt

135661
ataatatgct tttacttaat tatttgagga ttccctttag ttatcataat tttacatgat

135721
gtaaacaggt aaatgagaat atcttcaaaa tatatttttc agttttgggg tggttctctc

135781
agttctggtt tttgccaaat ataatagatt tttagtatct gagttccata tgacaaaatt

135841
tataaatctt gggtgtatcc atatggtatg ttataatcgg aaaagataga tgaaattccg

135901
cttttgtcta atgtctttat aggtcttgga gaaacttgaa gaagggttgt aaagtccata

135961
actttacaat gagacaaaat taaaagaatc caagccaaaa ttgtcctaga caatgaaaag

136021
tatcgctatg cagaagccaa atctcttaag ctcctccacc atatcagtca tgacacagtc

136081
tatagtttaa caattgtttc aatttggaaa ttaattttta gtactaattt aaatatttca

136141
tattagtata tgagaattct tccttctgtt caggctgtgg tatggggaaa agtcagttcc

136201
catcaatgca gattcatatc taccagcaca gtgattaaat tatcctcata tcctcttgtg

136261
tttgaacaag ctgtgtactt ttaattttaa tggatttaac tcaatattca atatatgttg

136321
attactgaat acaacaaaaa gtgtaataga cactccttga gaagctcata atctatttgg

136381
gcagatggaa caaatactta gaaaaattga aaggtagttt aggaccacag taaaaaaaaa

136441
ttgggggtgc aggatataaa gtatcaattg aattgtagaa gcaatatata ctgtgtattt

136501
tttcacctgg gtgagagggt gagactccgt ctaaaaaaaa aaaaaaaact atggttgttc

136561
accataacta aacatttaat ctctttcagt ctatcttact catctacaaa atggagataa

136621
tacctgtttt gcagtgcagg ccctgacata cgggtagagt tccataaatc ctagcttcta

136681
ttccttaact cttttaactc ttttcttcct tccttctttc tagctaattt ttaactctct

136741
atcctagaca acttttgcta aacgtgtata acatgtagta cctacgcata ggaatatgtt

136801
ttatagaaca gaattattga aaacagcttc ttacatttct gttatttttt caaaagcaag

136861
aattcatgta ttccttctga gccaagtaca tgcaataaaa agtaagagag attcagaaat

136921
tctgatgatt attctcccaa gaagagtgct tgctagagtg agggtcttgc agacacagaa

136981
ggagctgatg gggtgaactg ctggggtgtt acaaaaggcc ttcgggaaaa tacgtaatct

137041
aagtcaataa atcatagagt gaagattccc tcagggaaaa agggagtggt tctgaagaac

137101
ttacaaattt ttccaggcaa tagccacaga tgctagcaca agggcattat ggccacatag

137161
tgtgagcaaa agtgcttaac tttttgccct tcttctaata tttactctat tagcccagac

137221
aacatgagat ccagaagcct catgatgagt ggagaggaaa tataaatcag aagaaatggt

137281
caaaaagatg cctatattca cttccgcact taggtctcca agcctcagtt cctggcatga

137341
gtaggtagag gagaggagct tggaatagga tgtgagatta cagttttaat atagactgga

137401
ctggatattt gaatacctga aaatgaatct gaattctcaa aatgaggtgg ttcctgcaac

137461
tgaaaataac aagaaagcta caggatcttc tgccatgtta tccaggggtg gaaaagtgaa

137521
attcagtgga gccaggttaa agatggagtt tgggccggga gtggtggttc atgcctataa

137581
tcccagaact ttgagaggcc aaggtgggca gattacttga ggccaggata tcaagaccag

137641
cctggccaac atggtgaaac cccatctcta ctaaaaataa aaaattagcc aggtgtggtg

137701
gcatgtgcct gtagtcccag ctactggggt gggtgaggca tgagaatcac ttgaacctgg

137761
aagggggagc ctgtggtgag tcaagattgc accactgcac tcccgcctgg gcaacagagc

137821
aagaccctgt gtgaccttgt gtccaaaaac agacaaacaa acaaatacca tgtggagttt

137881
gtttactctt taaacaaata tccttcatgt gttgaactga actataatta tagttagtag

137941
ggcacatagc aggttttaat aagatatcta gttcttcctc ttaaggtaac tcgttagaac

138001
ttttatgaga aagaactaaa gaatttctaa tggggcagct aatccactct tttgtgcact

138061
ctgttctgct gatgatctga tgttagtcgg ggtttctgtt tgagattcct gagccttaac

138121
tgctgatgac agagttcaaa atcattgctt tctaactttg agaatgactg cctaatatga

138181
catcattttc tacccctgag tgctaatagt ctaccttatt cctcctgcct gtccttctcc

138241
ttgaggagga ggatcatcaa tgcactgtgt ggattgaagt ggcttcatac ccttttgatg

138301
ttaatgttct cctttgctta aagtgtgaac tgaatatgga tccctcattt atgaagcacc

138361
atgacacttc ctgggtaatg aacaattaaa cagacttctc agcaatagtg actatttttc

138421
tgatttttca cttcatggac aatattgtat gcaagttaaa tttgcaacta gcttgaggct

138481
tcacacatgg tgagtttgag aaattgaatt ctctacctca aatgtatttc cttttccttg

138541
aactctacat tcaggtcagc tgtccagttc ttaaacaaca ggttttggag aggcaatgag

138601
taataaaata gcattttctc cttcaattct atctgcattt gaaaaaaata accttttatt

138661
tttgattcaa agaagagagg agttttcttg tctttctaca tctgttccaa ctcctccaaa

138721
tgcacaaaaa ttttttcaga gcattccaga gtttctcaga ctgcacatag aagattttgc

138781
atatagatac atcttggcca taataacctt ctactgaatt agtagaaaat agatgtattc

138841
taggttttca tatctttatg gcaatatgaa tagacaaggc tcttcttgca aaaatatctc

138901
ctgaactgtg cgggagatgc ttggaagacc cagtcaaaat tacgaagtat cccaagtttg

138961
tatcctcctg tggcttcccc gtattacaat aatgtcattc tgatccaggt tccagtactc

139021
tcaagccctt gtccttccct tttcatttta gcttgcattc atccaagtat ttggatggaa

139081
attatcaata ccttatacga gaacgtatgg gaggctgagg cgggcggatc acgaggtcag

139141
gagatcgaga ccatcctggc taacacagtt aaaccctgtc tctaccagaa aaatacaaaa

139201
aattagccat gcatggtggc acgcgcctgt agtcccagct acttgggagg ctgaggcagg

139261
agaatcgctt gaacctggga ggcagaggtt gcagtgagcc aagatcacgc caccgcactc

139321
cagcctgggt gacagagcga gactcatctc aaaaacaaac aaacaaaaag aatgtaaatg

139381
attgggagtt aaaattatgc ttttcagttt tcagccatgg atcatgtttt cttgccttgc

139441
ctgattccta gagtctcact ccatgatgtt tcctctttat tataaagatt agatggcttt

139501
gcattgctgc catgtggcat ttatacttct caagcagctg tgtcatctta ttctaccgtt

139561
taaacttagt tttactttaa gtccacatct aaactgtttg cctgcatgcc cagcactttt

139621
tccaccctct acattttatt tgactggagc aatcacctta gcctctctag gtctttgctt

139681
atcatcactc tgctcattct tcaagcctca cttgattact gcctcctctg tgttgctttc

139741
ctggatttcc tcagtaagac atagtttctc cctttcatac ttctgtggta ttaagtatgc

139801
accagttaca tgtgactcat ctccaagtgc tttggcatgg agatattatt tatgttcctt

139861
atatgactac tgaccacttt tttctagact aaatattgaa acacttggcc agataatttt

139921
gcttaatttt gagtttcctt ttatactttt taaaacaaat ttttgaaatt aaattacatt

139981
ttgttaggtt gcaaatctga aaaagtccaa ggatgaggtg agtttgttgt ggtcagttgg

140041
gtagttgcta aactcatagc tggtttgtgt ctgctgacca gcacattgtt agcctagaga

140101
aagtctacat ggggaaccag attatgatgc aagcgttgct tggagagccc ttgatcaaga

140161
gcaaaacagg ttggtagact cgagggatag ttcagctagg tctgatggaa cattccagtt

140221
ttgccaacag aaggaaaaac attggaaggg cttatcttcc ccaggatctg gatctgttcc

140281
actgggtaac atttaataag cactaacatg gtctcttctt tcacttgcca tttcctgtgc

140341
ttctttttcc aactactaca tctcctttga cacattttct ttttcttttt cttttttttt

140401
ttttgagata gagtcttgct ctgtcaccca ggctggagta cagtggtacg atcttagctc

140461
accgcaacct ccacctcccc ggtccaagcg attctcctgc ctcagcctcc tgaattgctg

140521
ggatcacaga tgtgcgccac cacactcagc aatttttttt ttttttttgt atttttagta

140581
gaggcagggt ttcaccatgt tggccaggct ggtctcgaac tcctgacctc aggtaatcca

140641
ctggcctcgg cgtcctagag tgctggcatt acaggtgtga gccactgtgc ctggcctctt

140701
tttaagtgta tcaataccat cattttggct gcttattctg ccctgggagc cattctgtct

140761
ctttaggaag tttttgcgtg tatcagatct catcttttat attttgatgt ttaatagcat

140821
ttaaaggatt ttgttttgtg ttttttaaat gatttgaaaa caagtgtgct cactaattaa

140881
taaacagcag attcaaactt ttgttgcttt ttcaagaaaa aaatgaaaaa ttctgtaaca

140941
atatatctta gccataaaac acttgtaatc agcactcctc cagaaatttc aggatgtaag

141001
ttatcttaat gattatacta gaaaatcttg gaaagcaggg atatggctaa ctttttataa

141061
catgtatccc tactgtcaca acaagagtta agacttaata aatacagtca tgtgttgctt

141121
aacaactggg atatattctt gtaaccaccc aaggggttca ttttgcctgc tacctggata

141181
cagccaattt atcaagaacc aggaattgca gtagagaaag ggtttaattc atacagagcc

141241
agctgaatgg gacactagag ttctattact gaagtcagtc tccctgaaaa ttcagagggt

141301
agggtttttc aaggatagtt tgaagggcca gggaatggtg ctgctgattg gttggagata

141361
caatcatagg gatgtggaaa atggtcctca tgcatttctc aagtccactc cttttcttag

141421
ttcctgctta gcggaggtgt tagaatttgc ttcttggtgg ggccacagga ctggttggtg

141481
ggtccaggtg gggccaccag ttgtcagaaa tgcaaaaacc tgaaaagaca tctcaaaaga

141541
ccaatcttag gttctgtaat agtgatgtta tttgcaggag taattgggga agttgcaaat

141601
cttgtggcta atttgttagt cctacaaagg cagcctagtc cccaggaaag aagggggttt

141661
atttaaggaa agggcbgtta tcatctttgt ttcaaagtta aactataaac taagttcctc

141721
ccaaagttag ttggacctgt ccccaggaat ggacaagggc agcttggagg ttagaaacaa

141781
gatggaatct gttagtttag atctctttca ctgtcataat tttgtcactg ttaacgtttg

141841
caaaggtggt ttcactgtag actttataaa caccatatac ttagactata ctaagtttat

141901
taaaaatatt tttctttctt tagtaacaaa ttaaccttag cttactataa gttttttact

141961
ttttgaagtt tttaattttt ttgaactttt gactcttgta ataacagcat aaaacacact

142021
ttgtacaact gtacaaacat attttcttta tatacttatt ctataagtgc tttctatttt

142081
cattttttcc ctttaaactt tttaatttaa atgaagacag aaacacaata ccctaggtct

142141
acacaggttc tggatcatca atatcattat ccaccacctc cacatcttgt cccactggaa

142201
gatcttcatg gacaataaca cgaagctctc gtctcctgtg ttaacaatgc cttcttctgg

142261
aatacctcct gaaagacctg cctgaggctg ttttatagtt aatttccttt tttacaagta

142321
gaaggagtac actctaaaat aacgattaag agtattgtac agtaaataaa tacagcagta

142381
acagagtcgg ttattatcat tatcaagtat tatgtactat acctaattgt gctacatttt

142441
tgtatgcctg gcagtgcagt aggtgtgttt caccaggatc accacaaaca tatgagtaat

142501
gtgttgatct atgacattac cagagctacc atgttgatat aaacaggaga cagggaaata

142561
ctgggtagaa gagggcagtt ccctggcaaa agccttactc ccaagcctgg aaacctgcag

142621
tcctaaatgg gaataggcat tcctgtttgt gcatccaaat gttgcctttt ggcctgccat

142681
gcccctctgt cctgtatcca tataaacccc aaatcccagg cttgatgagc agatgagcag

142741
acaaacagaa gagcagagga gcagaagagt ggtgctgcag agaaagagag aagagaagga

142801
gcatctgaat gtcaagagga gtttggatgg ggatggtcag agaggagatc agctgcagga

142861
cagccaaact ccaggggaag atcatctctc actccatccc ctttccagct ccccacccat

142921
cctgctgaga gccacctcca tcacccagta aaatcctcac attcaccatc cttcaagttc

142981
atgtgtgact tgattcttcc tggacactgg acaagaacct gggtaccaag agggcactga

143041
gctggttaac acttaagcca tctgcggatg gcggagctaa aagagcactg tagcacaccc

143101
actggggctt tgagagtcac aggcacacac ccctagatgc caccgtggga tgggaaccca

143161
aaagtgctcg ccctggctcc tgcacctatc tgtctacatg ctccctctcc tataacaggc

143221
ttgcacagca gtgactgcgc aacagatgag ccacacccct tccacatgtc tgcaaggggt

143281
atcagggaac tctccccttt caatgtcagt aggtaatagg aattttttag ctcctttata

143341
atcttatgat accacctttg tgtatgtggt ctgtcattga ctgaagtgtc gttatgtggt

143401
acgtgactgt atttattgag tggatggtca attgtatgag gtacttgaat aatgagtggt

143461
gtgaaccttg gttttatgac atcttctgag agctgctttc aggtgggtat aagaagagat

143521
atttctagtc taggtcccca ctccttttct tagttcctgc ttagtggagg tgttagaaaa

143581
aaaggttgga ctctggcact attttcctcc attggttata tggactcaaa gccataactt

143641
aaggaagaat gtctattttt agatttggtg actgatttag ataggttgct acagaaagtg

143701
gtacaaagat atttcacaca tagaatatca aatccagggt gctttagcac tgcattccaa

143761
tggcctggga tggatgggtg gaagccctgg caagctgaaa taaaccaggg caagctcctc

143821
tttggaattc acaagtctga caactggtga ctcaggctct agtcaggaga cctgaatgtt

143881
acgtctggca tcacgatacc ttagtttaca gagattaatc taacaggcct tcagttagtt

143941
tgctttattt taaaattctg cttagctttt tgttgcctac taaatttctc ctgatgtata

144001
tttagatgta ggtgaaggct gtagatgtat gcactaccaa caccagcttc tgggagggaa

144061
cattttccca ctcacaagca agtgaacttt gctttctcca tgaagaagaa tgacctgcat

144121
gatggctttc agaagtggag aacatggctc acagttccct ccacagttcc tccatggcct

144181
ttggttgcat cttctctgaa tggaggagct tgggttatgt gaaaagcaga gctaccagac

144241
tacataaatg ttttagtgag aaggcagcaa attaaaatat cagaaatttt gaaaggaaag

144301
gtttataata gttagattta aaacatactt tgaggccagg cagcgtggct tacgccagta

144361
atcccagcac tttgggaggc caaggcggga ggattgcttg agggcaggtg ttcgagacta

144421
gcctgcacta cataacaaga ccttgtcctg tctctattaa aaaaaaaaaa aggaaggaaa

144481
gggaagaaaa agtgctttaa tattcagagg catgagagat gcaatgagta atataggacc

144541
ttctctaagg acactggggg agcactctac agaggtggtt ctaatctagc ctggcaaatc

144601
tctgttccct tcatgccttg tacttccttc ttctttgtga ctttgctaat gttattcctt

144661
cctcttggac aaatttccta tactaaccaa aaggccccaa gacacagggg gaaatgtggt

144721
aaatctgaga ctggaaggaa attaccatct aatgtcactc ttgtacagta taactattgt

144781
taatattatt gcbggggtca ctcatttatt catatcacaa acactgactg agtgcctatt

144841
atttgccaag catgggcaat aaagagttga agaccaacaa agcccctgcc ttcccagaag

144901
cttatttgct tgtggggaaa ataaacagtg gatcaattaa caaataagta gataacataa

144961
tgtcacggcc aggcgtggtg gcctcatgct ggtaatccca gcactttgga agactgaggt

145021
gggaggatca cttaggccca ggagtttgag accagcctgg gcagcatagg gaaatcccat

145081
ctctaccaaa acaaaacaaa acaaaacaaa acaaaacaaa acaaacaata aacgaaacac

145141
atggtggcgt gtgcctgtag tcccagctac tcaggaggct gaggtgggag gatcacttga

145201
gcccaggaca cagaggttgc agtgagccaa catctcccca ctgcactcca gcccgggtga

145261
cagggtgaga ccctgtctca aaacaaacaa acaaacaaaa caaccaaaaa ccaaaaaaag

145321
taatgtcaga tggtgactgt tttgaggaaa ataaagcagg gtaggggaac tagtgataac

145381
tggtagattt gggtttctcc atctctggct gcttttgcat cctcagtaag gtgagagtgg

145441
caaaggaaat tccaggttga ctttcgggtt cagtgaattt tctaccccgt gtctcttcac

145501
tgccctttcc ctccccagaa cctctaaaat ctgatcctta gattctgcaa tgtaagtcag

145561
cttccttctt cctggttgcc agctcactac attcttattc ctggataaac caaaaatctc

145621
ttccttgttt tcatattttc aaaaagatgt agaaatctct cacctgctca tgttccttcc

145681
tttttgtctt gttggtatat atacctttta caattctttc actaccaaat gtagttggat

145741
attgggatgt agtcacaaca aacacataaa tacaattcac catttttaaa tggacttatt

145801
catttagtct gcttaaaatt gagataataa cacacgcacc agttgggttt ctctgagaac

145861
tctgggcatt tttaatcctg gcaattttta aattgcttag cagtaaaaca gtcagacaac

145921
agcacctatt gttataaatc cctgcctctt cttacctcaa tgaggctatc ctttctctct

145981
atcaattctg tcagcagaat taagaagagc cattgatttc cagtttgttc agcgtttttc

146041
ttcttaggat gggagtgatg acttctaacc tctttacatc tagagactca atttaagtct

146101
acttctttca ttcagccttc tctcttcatt ttcagctgcc tggaatgtct tctttctctc

146161
agttcctatc tttgacatta aaaatcacag tacttagtta tattctacct cacaccaatc

146221
attttacttg ttaatatctt ttttcctagt tagattgtga cattttggaa taaaagaaaa

146281
atatcctttt ttactttata gctctccaga tttcattaga ttagtataga ttcgagtgcc

146341
ttttatatat caggcaatgc ctagtgtata atatttttac ttatgggttt tagcatttaa

146401
cttatttaat gatcacaaca ttcctatgat gttatttgtt ttcataattt gttgaaatga

146461
aagctgatgg tcagaaaggt taaaaagttg tctggtcata atttttgagg aggcagagct

146521
aggttttgaa cgcaggtctg tctgattctg agaataatcc tgtgctcctt cagctgaacc

146581
acacagcccc tcttagtgct ttgtctccat agacactaag tgtattcttg ttgattgagt

146641
gaattaacga gtgaattatc tggagctctt tctgcttctg ttttcttctc tgtacaatga

146701
ggatcatcac atgaacctga tctaagaata gaatagtcca actgagttcc cttaatttgg

146761
taaccaagag agagtagagt taattaacta gaaccctttg ccatcacttc tctctaaact

146821
tttcatcatt ttcctctaaa agtccggtcc tgagctctat tacaagatag aacattttag

146881
cctctatcga agagagcact attaatattt tatggcattg gctccttttt tcctaatact

146941
gtgggattaa aataatgttt actaaattct ggatgttcga ttcctgtttt ttcatgatat

147001
tttataatcc aggccttctt catagagaca cagggctatg ttttataact gccagggtca

147061
agcaaagaac agcttgtgtg agatacttaa agaaatagct aagcagtaac ttcagacctt

147121
ctgtatattt tcctcaaaat tttctctcag tttttgtctc cctacaactc atttttagaa

147181
aacaaaaaca taacacaatt ttgccctttt aaaagataat acagcbgggt gcagtggctc

147241
acgcttgtaa tcccagcact ttgggaggct gaggtggggc agatcacctg aggtcaggag

147301
ttcaagacca gcctggccaa tatggtgaaa ccctgtctct actaaaaata caaaaattag

147361
ctgggtgagg tggcggcagg cgcctgtaat cccagatacc cgggaagctg aggcaggagg

147421
atcgcttgaa cctgggaggc ggaggtagca gtgagctgga attgcaccac tgcactccag

147481
cctgggcgaa agagtaagac tctatctaaa gaaaaaaaaa tgtactataa taatttacaa

147541
agtacagaaa atatctaaag gaaaagaaat aacatctcac aacctcatca tctagatatg

147601
actgcaaaaa ttttggcata tttcatttca gcttttaatt aatttatttt tgcagaagac

147661
atttatttca gatattctaa ctttataatc tgtagaattt taatgatatt tttgtatgac

147721
atctatcata aacatttctg catgtcattg aaatatttat aaatgttatt tttatttaaa

147781
caatgcataa ttgatataac ccttctctta aaattggtga tttcacatac ctggggatga

147841
gccgatgtga aacaaaagag aaagggtaag agatagctag tctcttgact catttttttt

147901
tttccatatg acttgaaaaa aagaacttat cttagagacc tctagaatag ttagcacaaa

147961
tagatttctc aatgtggtta agatgaaata cagatactga atttactctt ttatgtgaaa

148021
taaataaaaa ctggataaga tatatatagc aacagttttc aagacattat acctcagaca

148081
acaaaggata atgacctctg agagagggaa aacaaattag gtgagcctgt gattgcccca

148141
gtttactgcc tggagagaga ttccaggcca gggtgcagag agaagggttg cgaatggaaa

148201
ctattgctct ttctgagtta aggagagaga cctgaaagtc tgcaggtaca aagatagctg

148261
caattcatga gaaagagttc cagagaaaag aaaactgaac agagagtgag ctctggattt

148321
ctgtagtgtt cctgctgact cttctgctga atcatgatca gtgcatgtgt gtggctggag

148381
aaagaacctc tgaaaaggtt tagagggaca aatccttaga atcacatagg cctgggaata

148441
gctcctcttt ccaccagaaa gagtataaaa accatgaaat tcatgggaca ttaggtagag

148501
tacttagaag ggttttgctt cagcagtgag aaaaaattag tcctagacca aatgttgctc

148561
tgatcctaac aaaacttaaa aaatgagacc ctaaaggata aaactgtttc caggtaactt

148621
aaatatatac cagaacaaag ccgaagacta taggaatatg aaaatatcta gcagtcagta

148681
aggtaaaatt cataatgtct aatatgcaac caaatattac catgaatata aagaagcatg

148741
aaaataaata cccataattc caagaaaaat caattataca taattgcccc atcaatgaca

148801
cagatgatgt aattagtaaa caaagagcta attataactg ccaactctag ccattacaca

148861
tgttcaagtg gctagaggaa agatcaaatc acgacacaga agaaataaaa agacaataaa

148921
atatgtacag atgaaaatta caatatctga gatgaagcat aagcgagatg ggattcgcag

148981
cagattagat atagaagaag gattaatgaa catcaaaaca tgtatgacaa cagtagtata

149041
aagtctgtaa gaaaagaaat ggaaacatac tggtataagg ttttacacta tgtatgaaat

149101
ggtgtagtat cacttgaaga gagactgtga ctaaagacca ctgtaacctc ttagggaaag

149161
aaaaatatct ttttctaccc atcctgggtt cacagctgag gccactataa caaaaaacag

149221
attaataaca cagaagcata cacatttact taatataagt gttatgtgac acagtagcca

149281
tcataaggaa agaagactca aagaaacaga tctgagtatt tttatagtag gtttgatgaa

149341
gaatggatag tcatggagaa atataatggg gcatataata caatggggtt atgatctaat

149401
ggtagtaaac tgggggaaat ttagcbgggt ttgcttgttc agatttttct ccttgacctt

149461
ttgtcgtgag agacaaggat gtttcttttc tctgggtata gggagggcac ctctcacatg

149521
agggacttat gatctgcttc agagaagtgc cagggaagaa cagagtgacc gtcctgcttc

149581
tgcagttttc tcaaattcat acagcttaaa atatttaaca tgctaaggtg ttacattttg

149641
gggtagtata tcttgatacc catcacctga aaccaaccac tttataatag taacacaaag

149701
agttgtacat aatataccat aaaggtggta aaatggaatc attggaaaag tcaattcatc

149761
caaaagaagg ctgaaagagg aaagcaaaaa caaagaagag atgggagaaa taaaaattaa

149821
atggtaggga catgagcatc cattaatttt ggtatacagg aggggcttga ggggtgtcct

149881
ggaatcaatc cccctcagat accaaaggat gactgtatat tttttaaatt aagagacttt

149941
cattctttaa atattcttga cttacagttt tttaaaaaga aaaaaaatca aagcatagta

150001
tagttgttaa atcattttaa tagtatattc agtggctgaa atgacaggga gtatcaatca

150061
ttatttattc aatataaagt tatccttact gaaaaaataa gatataactg ggaaatatgc

150121
ttggatccct cacacatcca cttaatttct taaaggaaga aagatgaaac acatgtaaga

150181
acagaaacaa ataaaccatt tactgtaaca ttccaggaat tgtgggatcc ttttcttccc

150241
aagtttattt atttgcttat ctttatctcc tagtggtagt ttgtttcctt tggtagaata

150301
tatggcagtc ccacattggt gacacctggt gctcccttca tccaactgga tcactttgag

150361
attcagtttt acaccttttt agcattttct ttgtgttcat atatcagtta tgatgagcca

150421
ctgataatat tttgttctaa aacgaaacat attacttagt acttttttta ttgtctcgct

150481
gacttttaaa atttgagtga tgtacagact ttgttttttt aatgaaatat aaatattttc

150541
tcatggtttc taaattcctt ataaaattaa attaattcaa tctgcaaaaa tattaaatgg

150601
taagagaata aactcatcac ttagatgttc atattaaatg taaatggcct aaatacccca

150661
attaaaagtt aaaaatggtc taattgaata aaatacccat atccaactat atcttgccta

150721
taagaaaata ttgccacttg cagtataaaa atacaaatag gtaaaagata aaaggatgga

150781
aaaagacata ctattttaaa ctaataaaat attaattaat taattagtca gatttcagga

150841
cctttttctg aataattgat agaataaaca gacaaaaata tcagtaagga tacagaaaac

150901
ctccaaaata ttatcaatca ccttgaatta attaatattt atggggccag gcttggggct

150961
catgcctgta attccagcac tttggcaggc cttgagctca ggaattcgag acaagcctgg

151021
gcaacacaca cacacacaca cacacacaca cacacacaca cacgtgtata tatatatgca

151081
cacacacaca tcagctaaaa gcagcagaat acacattttc ttcaagagaa cacagaatat

151141
ttagcatgat atgctatatt ctaggccata aataaatctc aacagactta aaataattca

151201
gctaatacaa agtatattct gtaactacag tggaattaag tttgaaatta atagcaaaag

151261
atatctggca aatccccaaa tatttggtaa ctaatatcat acttctaaat gacccagggt

151321
caaataagaa atcaaaatag aaatttgaaa gtgtttgaac taaattaaac acacatttca

151381
aaacttttga gatgcaacaa cagcagtatt tagaggaaaa tttataatag tatagaccta

151441
tattagaaaa gaagatctca agccagtgat ctcagtttct acctgaagaa actagaaaaa

151501
caaaacaaat aaatccaaaa taagcagaag aaagtaagta ttaaagacca gagctgaaat

151561
caataaagta gaaaacagaa aaacaaaaca aaacaaaatt taataacacc caaaacttgt

151621
tattatacag atcagtaaga ttgataaacc actggtcaag actgattagg aatttatcaa

151681
gaagaaacga tttccttttt ttcatactgt atatgtagca cccaaaaata aataacttta

151741
gtataacatt tattcatcta atacagaaga cagaaatgag aaaagtggca tcattacaaa

151801
ttctacagat agtaaaagaa caataagata atatgataaa aaactcaggc caataaattt

151861
gacaacttag ataaattgca caaattactt atatgacaca atctaccaaa gttcattcag

151921
gaagaaattg ataatcttag tagctgtata tctattaaag aaattaagtt gatagttaaa

151981
aattatccta caaaacgtat tccaagctct gactgtttcc ctagagaatt gtacccaata

152041
tttaaggaga aagtaattct aattctgcgt aaacttttct aggaaattga agaggaggaa

152101
atatttccca actctccctg aggccagtgc tactctatcc aaaaccagaa aaagacattc

152161
caagaaaaca aaactacaga ccactgtatg caagaagcaa tcggaaatta aaaattgtaa

152221
aatatcattt aaaatatcag aaaaagtaat tatgaagtac ttaggaacaa acctgacaaa

152281
agtggctcaa gatttgaaca ctgaaaacta taaaacattg ctgtaagaaa ttaaagaggg

152341
cagaaataaa tggaaacctc atttgtgaat tagataaatt taacactgtg aagatattaa

152401
ttttccttaa attggtctat aattcaacag aatctcaatc aatacctcaa taggctttta

152461
aaaatgcttg caaaatttga caagctaatc ctaaaattta tatgaaaatg caaaggacct

152521
acaagaggca aactatcttt gaaaaagaag agtaagtttg gaagacatat acttgccctc

152581
agagctcatt ataaagctac agtaatcaag acagtgtgag actgaaataa agatagacaa

152641
agaaagacaa tttctaggtc atgagagtta tgtttcctaa aggaaggcag cagatgctta

152701
ttaactttcc ccgtgccctc aggatgcctt aaacagtggt tgccaaccac tagcagcttt

152761
agcaccactt ggaagctttt tagaaaagct aattactggg cccatcccag acctactgaa

152821
ccagaatctc tgtgggcaaa gcccaggaat ctgtgttttc acaagctctc caggtgataa

152881
tgatgtccat taaagtttga gatccattgc cttggccttt ccctgctaga aatcctccag

152941
gatttgggag acaggggaag aggtctggag agagtggcag aattcaacac cacagaatga

153001
agaggaaaat tgatggtctt tgtccatgga atccattaaa atatactctc attgctgcca

153061
ggctgagctg atgaataaaa aataagctaa tctcaaatca agccatcagg ctattgatga

153121
taattgtgtt ttagggtgag caaacagctt taccaagctc acacagttga gacaatttgt

153181
tgtttggaac tatcttactg taagatcctt aagaagaatg cagaagtatg aaaataaatc

153241
caggactcag aaatctttca actaaatctt taaaattctc tctctcatgc acacacacac

153301
atatgcacac atacacatat agtaagattt catgacacat gagacaggat gtgaagctga

153361
acagttcgat gaatgcctga gtggtaagat caccttgaag aaccagaagt gagggtctat

153421
tctagcbggg tatgagctac aaactcattt cttggggaac acatgaacac atcggggagg

153481
ctaagtagct tctgaggcta ctaatagaat ttcagtcatt tctcctgtca tctgaaaaat

153541
atatgatatt gaatttctaa aaatgggttt agtgtagtct agtcttactg tctaaaacta

153601
agatgtggct tattccaata accaaagtga ttccatccca tgtgagggaa aaaaaggata

153661
atggtgaatt aaaagcacct gcgtgtattt gttgctcctt tagaggagtc tctcttcatc

153721
aacgttaact ttctttccta cttttgatct ggctgctaaa agtctaggtt tagatctcaa

153781
accattgtcc ttctctgcat gatgtaatag ttacaattac agtctcaacc ctctggcatt

153841
taatgaagat gaaattgatt tctttagact gaaaacaaaa aaatcactta caatcaggat

153901
actgaatatg gtagcaagta caaggtccca gcttctagta gacttggcag actgtcaagc

153961
tcttactaag tgaccccacc ccatgccttt ttgtcttttc tgttgccaca caattacaat

154021
aatttgttct ctgaatgcca gagtactgac aaggaaagga attctgaagc tggctgagag

154081
aagtcgtgta aatctcccaa tctaggctcc attgactctt gtctctttct ttgtatggaa

154141
ctgattttat aatttctgtg gcaatgaaag actagtaccc aaaatgactg ctggtccttt

154201
gtttattgat caatctgagc atggactaga attcatcctc caattggtaa caagaaaaaa

154261
ttggatgggg aagcatacca ttggctaagg cagcacagca agtttgaatt tggctgcctc

154321
ttctttcaat attggttgac atcatcaaga gcagacattg gcgttggagt taagagtatc

154381
aagagagtta ataaatacca atttagggta atattttatg cctagtcttt atcttttggt

154441
gaagtggttt ctaatatcat ctcagactaa atcttatggg atatttctac ttgtagatgc

154501
taaggtatta agaaaaagct caaagtagtt gtgttttcct tatcttccta aaagtttaga

154561
ttaaagatgc caaaaatttg tgtgttggta tgtgtcaaag catttgaatg cccttgtaga

154621
ctattaaaac ctttgttctg taccaggcac tgtattgagt atattgcatg tatttattat

154681
tatatttagt tctcacagca accgtacaca ataattacaa ttccttcctt tcactaaggc

154741
atagggagtt taaataaatt agccacagta caggatggca taaaactgta gcagagccaa

154801
aactcaaaca tgtctctgtc tgactcaaaa acataggctc attctcctag agccaggcaa

154861
caacctgaaa gctcttgagt tgacttttct agttctgtgg atgaatgcaa tcatctcagg

154921
acccagataa acagaagtcc ttctttctta ttcgtatttc tcagtactag gccagtcagg

154981
acaaactctg ttctccatgg ccgtgatctt gaagaaattg agatttcatc caaaggaaat

155041
caggtattga aacgtgtgtt tatgtgtatt gattaatctt ctgcctgttt ctggaaacat

155101
ttgaagaaat ataacaaaaa gcaaatatcc tgaaactgcc taatgaacct gatctctctc

155161
tctgtctttc cctttctctc tcataggtct tttgcctgta tttctctggt ggaatttact

155221
aaataattat atcaggtgtc ttcttattgt acttgactgc tttcatcaag gtaatcttga

155281
ggacagagac ttcctttgtt agccagggca ctctagggga acagaaatta cacacacaca

155341
cacacacaca cacacacaca cacaggaact ggttcatgga ggctaaaaag tctcaaaatc

155401
tgcaggccaa aggcttgaga acccggagtc ctcattgtgt aagttccact cagagtctga

155461
agaggggaga agacagatgt cccagctcag agacctttag gcagagagag aaaattctgt

155521
cttgctcagc ctttggttct tttcaggcct ccagtggatt agatgaggct cacccacata

155581
ggggaaggag tctgatttcc tcagtctacc aatgcaaagg ttaatctcat tcagcaacat

155641
cctcacagac acacccagaa taatctttca ccaaatatct aggcactttg gcccagccaa

155701
atagacacat aaaattcact tccacacttt cttactaatc cgtgcattct ctccaataca

155761
gggcacccgg cctggcaagg agtaagtgct ccatatatat ttactaaatg acaagagatg

155821
agattatcct tagactatga ctcagatata gacaatcaat tattaatacc ctatcatttt

155881
tccccactct gacaacccaa actgaaaaat gttgggattg ccttttttga caatatgatt

155941
ttctctgaat gcagactcat gttttgacct tccctgtctg ttcctgttta gtattcatgc

156001
tggcttaact cattgattga tcaagtaacc attgagcatc tgccgtgtta acactctgaa

156061
caagatcctg taatatgaat ggtgtttagc ctgatgaata aagtgtggtg tctgtgcatt

156121
catttttata tatttattgt ttttaaccaa actttaccca tgtaaagaat aacattgatg

156181
gcaggaactt gaatttggat ctacgtacat gttccatttc agactcacca tgaaatgagg

156241
tgcttgcatt tttcattgct gattttacaa tacactttca caccttttgg gtaaaatttt

156301
gcaatcaatg taactgaggc agcatggtat gaaagcaacc ctggaggtgg aaatagaaga

156361
ctagaattta aatcttggtt atgccactta ttggttgtat gatttttgtc aagtcatttg

156421
acccgtgtct attcagagtt tctttgctag aatgaaggag ttaactagaa tttattgatc

156481
tcagtagtca gtctcctcag gcacagataa atcttggata tgtatcctga gatagctttc

156541
ccatttccac attgaagaca acattctatt ttagagcaaa aatgaattat attatttaag

156601
aatatgagtt tcagaattca gactcatgct tacgggtttg aattctagtt ctgccacttt

156661
cttactatgc agactttagc aagtcagtta atgtttgtga gcctcaggtt tctcaccagt

156721
aaagcagtgt gagtaataac tatcatatta tattattaca agcataaaat gaaataagag

156781
tacttggcac aaagaaggat cttaattttt agctttttaa aaaagctgta tttgtttata

156841
tgcagtatgt atatatatat tctcaattct attattatag actatattta ttatgttttt

156901
cataaagtca ttagtttcac tcaggaatta gttgaccctt gtgagataca tggtttgacc

156961
acttttcact ttgatgttct tcagaaaata agacaattag aaatctctga ttgtaatctt

157021
catgtaaaat attttacagt catggctaaa atgatcccag gagtggaatc atacacataa

157081
attcttttct ttattctaat aatgttacct ttagtgtcta tgccaagcaa gtatgttatg

157141
tgttgagata aaaattctta gtatgtttgt atgtgacatt cccaactccc atcccactga

157201
agtctatatt tacctagttt ctttcttttg ttttcctcta acattcatgc tattttaatc

157261
aatgttcttt cattttgaag cccccaataa gtttgacccc aaagactttc agtttgcccc

157321
tgctattcat aagcatactt atgacaatgc atgtctccca ttcttttctc atatttacac

157381
cgatcttttt attgggacaa atgggtttgt tttttcatgc ttgtgtttaa tatctcactg

157441
agttcagcat aagttattaa acataatttt ctgttttctc tttctccctc aagactttct

157501
ttttctctag acctttattt cctaactcca gagtatttgc ccaggtctat aggcccctct

157561
ctcttttgct ttcttaccaa cccatccacc ttcttctgtt tcctattgcc caactggctt

157621
cacttaaaca agagcatttg ttatttgtac agagtgcaac atataattgt cctactctgt

157681
ttggttgcta taacaaaata tcatagacta ggcagcttat aaacaacaga tatttatttc

157741
tcatagttct ggaggctgga aaatccaata tccaggcact actggcagat ttggtgtctg

157801
gtgagagcct acactctggt tcatagacag ccatccattt gcbgtgtctc catatggtag

157861
aaagaatgaa taaagtttct ggagtcttct ttacaatggc actaatccat tcatgaaggt

157921
ttcatcccat gacctaacaa taccattgta ttgggggtta tcttgcaaca tatgaatttt

157981
ggggaacata agctttcaat ctatagtaat gaagtaggaa attttccctg atcctttcat

158041
gggcaggaac tggagtatgc ctatttcaca gaggtcttat cagataaaaa aattctccat

158101
taaatggcaa aacaagtaac catttgggat tcctgggtgt acagtgccta ctattccaaa

158161
atgagattat tgaggctaac atgacccttt gtatacaaag acgggggcag aaataatatt

158221
tctagcaaat ccacacatct caatcacatt taatttcaca aaatttactt ctaataagca

158281
ttgttccaac taacaaacca tctggtgcta gtctaagata gagatggctg aagtgctcct

158341
gattccagta ttttaggtgt taaatctcca ttctaacatt gtcaatcctt aactggagta

158401
ctcaaatatt aactaacttc ctctaggata taaattaata tgtataccac attctatgtg

158461
aattatttta attatattac atgccatata caaattatat ataggtttag tcttcctgaa

158521
tattgcaagt tgagtctgtg agagaaaaaa ttaggatgaa ttgagaataa ctagaattca

158581
gaattctttt tcattaagtg ttgactgtgt taactcatat tcccggttag gtagcaagtc

158641
ctatgaagtg tgattttctc ctaacagcta aaaagcagaa aaaaaatgga tttattctag

158701
ttaatgactt gctttttcta tttttataga aaaaatgaag taaattattt cacttttctt

158761
gatgctatta ctattttgtc aggaagatag atcttctaaa ttttaggaaa ctatgaatct

158821
aagttctata ttgctctcat ttcctttttc tctttgtctc tcttctgttg tagcccctcc

158881
ctcaccgcta agccttcacc ctgactctac cctgccccca ctgccttttg ttctttggaa

158941
gacactcatt aacatttgct aatgtatgct aatgagcaat aattagcatc tctaatgtga

159001
acaaaagcag tgctacaaag gaagggtaaa gatgtgtaca gagttcagcc agccttttat

159061
gcttctttat gccttaggaa caatcctctt ctttcagttc tttcacaatt ctttagtgtt

159121
ttttgtttgt ttcattttgt ttgcttatcc atgaaccctg aaaaccattc ttcttcttga

159181
gttagaatat tgcaaaaatg ctacggagga cagaaagatt cctttttgtc ctaaataacc

159241
caaggatata agcacagctg ctaagaggtt ataatgcaca tttgtatttt catctggttg

159301
ttattttggt atcctattac tagaaaaggt tttaaccaga aaacctcaca caagataatg

159361
tatttcattt taccacactt atttacagtg gttgcccttt atggtggtaa ttgcaatgtg

159421
aaagcataca ctctgaatat atattatgac agcatggtta aataagaaat gttccctccc

159481
tcaaacaatc taaatgcaaa gaaaatgcaa gactcaccac ttactttttc ataaccacag

159541
agggctctaa atgtctttgt aaatagctat ttatttattg aatatgtata gttttttttt

159601
tgaaaaagcc agccctccaa accacataga gtaagagctg tttttgttct ttctgtagac

159661
tgatggtgtc gtgaaatacc taattgcagt ttctcacaaa tactccagca tgtaatttgc

159721
catttgcaga accaggcttc acatttcata tttgctcttc cagctcaggg gtggtagaat

159781
ttggaaacat accagcaacc cacttcactc agcctgtgtt taattataat ttcacgtaca

159841
ataaaagcag aaggaaaacg tgcaaaaaaa ttggtgtgca tccctttccc ctccttctta

159901
cgtatataaa aaagatttat ttccattgta aaaggataga atggggatct ttattttgag

159961
tagattttct atttttgttc tttctgtttg cctcagagtt agtgtcctct ctctgtgacc

160021
tcagagtaaa atgtgtttct ccataggctt catcctgttc tatttatcaa ctatattata

160081
tttatcaatt attttatatt gtgtttttaa taaagcagac atcagcagct atttattttc

160141
tacttctgag ggcctaaaga gtctcagaaa atgagtgtaa tctagaaggg aaaacattga

160201
agagtgacag ctattataac agttgtgatt tttgcctgcc tccctctttt ggattggtga

160261
gtcctaccaa aaaccaaaac tattattctc cttgtaattt tgaaaccaca gagattgaaa

160321
ataactattt agtatctcca agatattata atgtttgaaa atatgaccag ttttgggggc

160381
atttattaca aaagtttcca gtagggtgtt tttgaatgtc tgtgccctct ggttttcaca

160441
aaactggtct taaggaagat aagatactgg tacacacaga agaaatatca gcctacgtct

160501
gtctcattaa atcttatccc cagatacttt gatgatattt aagtgtaatg atctcattct

160561
gtgtttctca ctcctgataa ttttttaaat gtcttatagc ttacaggttt attaaggtat

160621
ttgatttatt taagaactac ataattattc tcttcattca atggcttctg aaatattatg

160681
tttaattcta tcatttgaag gacttgggat tgttataaac aaatggcacg agcttctttt

160741
tgtcctgacc tagaagtagc aaagataaag ggagctgctt agttaacctg agtgagattt

160801
aataatcttg ggtatatttt attctagagt aagaagaatt gcaccctatt acttttattc

160861
agttttgtat gcagtagctt ctgttgtcta cttcacaacc accaatagtg ttatcataaa

160921
ttcagagtgt tgggctgtat tagcccattc ttgcactgct ataaagaact acctgagaca

160981
gggtaacctg taaagaaaat aggtttaatt ggctcatggt tctgcaggct gtacagaaag

161041
catggctgct ttctgctctc cagcctcctc atggaggcct caggaaactt acaatcatgg

161101
cagaaggcaa agttgaggaa ggaggtacct cctacatggc cggagcagga ggaagagaga

161161
gaaggggaag gtgctacaca cttttaaaca agatcttgtg agaactcact attccaggaa

161221
cagcaaaggg aaagtctgcg cccatgatcc agtcacctcc caccaggcac ctcttccaac

161281
actggggatt acaattagac atgagatttt ggcacaaatt tgaaccatat cctgggccat

161341
tctctatatg gagatgatgc ctgaatatga tttggtgact cagtctagca tccaagtggc

161401
tcattgttgg gcaattcttc tttagtcttc tttagggcta attttactca ttccttttga

161461
aaattggatt gatttacttt ttgtttggtt ttaagaaagc aaaatatcta aatgctgttc

161521
ttggcatagc ttatatacat atacatgcat acacatgtgt aattttcttc agatcaaaat

161581
atgcatcccc atcattcgta ttgctataat cagaaattag taatttgagg ggcaactgaa

161641
tgaccttata cctagagttt tcagagtata atattacaca gtgtgtattc ataagaatgc

161701
tgccttttaa agaggttttt ttttaaaaaa atcatagctt attttttata gtttcactgg

161761
tctgtcctcc cttttctctc tttttttccc ccttgagaag agagatttca catttttgtt

161821
aaggggctca taatttcctt atgaaatatg acaaatttca ctttatctta aaagcaaaat

161881
attaatagta cagacagctg aaggtggtct gagttaacct gagttacaca ttttatatat

161941
atatatatat atatatatat atatatatat atatgttaaa aatatttatt tgtcatatgt

162001
agcaagacta aaatgcaaaa ttttgcttta tgcttattct tttccagtat catttactgt

162061
aattctcacc ccatatttat ttttttactt ctctttctgt ttctctcctt tctcctctca

162121
ttctttttct ttcttttctt ctccctaccc catcttttag ttccatactt ttgaattgct

162181
atagtggact caaatctaag caagaggtat attagtaagt tgttcagtct tttaacaaag

162241
tatcagtcag agaagcacag cccagggata aaccaaaagc agaaataaaa ctgaggaatt

162301
aataatctaa ttcgtgttgt tttctttaca ttataggtgg ttcatttcat agcctacatc

162361
ttcaatttct caattctcat tagatctttc ttaacagcat ataagaccat tctaaatagc

162421
aaaaatagct gtatcctttt actcactgcc catcagttca taaagccact tgaattcagc

162481
tttttgccca cacaactgca ctaaacatat gcctgccaag atcatcaata tctctacatt

162541
gtcaaatcca gtggtcaatt ttcagtccac attgtactta gcaacttatg atacgtctct

162601
gatgcacatc ttctgccatc cacaatctct gactttcctt ctacttaaga gctgattgtt

162661
catttttgat ttcttcagtt tgttcttctc ctgttcctca ccattttgag tctccttttt

162721
ctgttttgtt taccctcatt ttctttgtta tctcatctgg tcttatggct ttaaatacaa

162781
tgtttttgct gataattccc taattcatat ttccagtcca gacctttctt ctgaactcca

162841
ggctcaaata ttcaactgcc tacttaatgt catgcttgga tgtctagaca gcacctgaaa

162901
tccaacggat ctgattaaag tcctgatctt taacagctcc tacctaagct attctcccta

162961
cagtcttcca tcttcttttc ctgtaattcc attcttcagg tgctcaagca aagaacctgt

163021
tgctatcctt gatttctcta tttctctcac atcctacagg gatgacatgg gttcatttat

163081
gcctgtcatg ccactgatta acatccctat caagaaagtt tagtctgagg taaaaacatc

163141
caatttgtat gagaagggcc aacattgaca ttcttcgtac acaaaaaaga atcctgagaa

163201
gaaacacaaa agagctaaat aatacattgc tgttgcagct taggtaggct ggagaagaaa

163261
cccatacata atctcaaacc ttactgttat aaagtcattc tttttttttt tttttttttt

163321
ttttgagacg gagtcttgct ctttcgccca ggccagagtg cagtggcgct atctcagctc

163381
actgcaagct ccgcctcccg ggttcatacc attctcctgt ttcagcctcc cgagtagctg

163441
ggactacagg cgcccaccac cacacccgga taatttttta tatttttagt agagacgggg

163501
tttcactgtg ttagccagga tggtctcgat ctcctgacct catgatccac ccgccttggc

163561
catttttttt tttttttttt taagagggag tcttattctg tggcccaggc tggagagcag

163621
tggcacaatc tcggctcact gcaacctctg cctcccgggt tcaggtgatt ctcctgactc

163681
agcctcctga gtagcbggga ttacaggcgc ctgccaccaa gcccagctaa tttttgtgtt

163741
tgtagtagag gcggggtttc accttgctgt ccaggctggt cttaaactcc tgacctcaag

163801
tgattcatcc acctcagcct cccaaagtgc tgggattaca ggcgtgagcc actgcgcctg

163861
gcctataaag tcattctttt gcatcaaata gtaagactca ttaaaggcag tggtattttc

163921
ttttactgtc tacaaaccct tatccaagag cattttctct atattccttt gtgagcacac

163981
aataaatggt aattcaataa gtgaattttc agtttccaaa ataataacct ggagctataa

164041
acattgcttc aagaagtaaa tgtgggtcag agaaaaaggc aataccattc aactcttctg

164101
gccacttggt cactgtgtta tcctgaagaa gcataaacta ctttcagcat tatagattta

164161
aaaagaagcc ccagaacaac atccactttt ctgaacgact cctatgcctc tgaaatgtga

164221
cattttgctg ttgtttcttt ttactgtttt taattactga gtctatctgc atgaaatgag

164281
gatctgggtt gcctaggagt tcatctgctc ctattgcata ttcctctttt aactacacat

164341
acttcaatgc agttttgctt gctgcctcca acattttgac agacttcccc tcctcttcct

164401
tcactatcct cccatcactc tccaggagac aaggttattt ttaaagtgca tgatcaatgg

164461
gcattgggga gcagctgagg catgaagaga tcatacgatt gggaataagg tactagggac

164521
tgctgagaga aggaatggca acatgccatc tcagacattg tctgagaaag gaaagggttt

164581
gtagctccca ttcaagtatt ctgagctatc tcttcacaca ggtttttgtc ttggagggag

164641
ttcttaacat agttctttag cattgcttta agttgaagga gatataggcc agtgctgata

164701
gttacttttc aggccaaata atgttccatt aaaatcgagc ttgctctgag gatcttggta

164761
gtgtcttaaa tctcctggtc atagtgctgc tatttggttc ttgatgctta tgacaccttt

164821
gctgagggtt tgaatcaaga acaaaacaag tattatcaca atgactataa aacatgactg

164881
ttccacgatc agacaaagga atgcbgttaa gcaaagaagg cacctaagga gaatgtggag

164941
atgaccatgc acagaccaga atcactattg gaaaaccaac tcaagaggag ggactgggtc

165001
atttctgcag cagtcttcat tgcatcactg agaaattgca gctctgtttt agttctctac

165061
ttgccaccac agggaatatc ttcccttatg gacttttagg ttttatttaa tggttattta

165121
taaactattc cttctgtgcc ggagaagatg attcatgact ctagccctgc tttttctctc

165181
ccgtggttat tagaggaaac tgagttgttg cttatctctt tagcttggga taccttattc

165241
tgctcttttt atttaatata taatctttcc taaagatttc cttatatttt tgttcattta

165301
gtaggttttt ctgttttatt taattaactt tatattatca cattctagtg aaataatcat

165361
cacaaatcat cctaatacat cgtgcaaatg ttttaaaaat gtgctttggt tgtgcatatc

165421
gcaaagtagg ctgtgggtca gcatttgcta tttgtcctca gctgtttctt ctttatatat

165481
aactgataac accctgctcc aatgttaatc ttatatcatt aaaattcttt cctagagaat

165541
ccttctttga ctgaagaagc ttagtggtga cattaattgc aaataaaaga ccatgaccta

165601
ttgtagaatg tggaatatct ccttagaagt gtctgccttc attattgcaa actttcagta

165661
gtgacataaa gatctttgtc ctgtgtagtt tcagttgcag ccagcaacag aaggcatatg

165721
ttcactttga acaaaagaac atttattttc acattctgtg gctgatgttg agtgataaca

165781
tttttgcata tcctaaaatt ttttacccag atgcbgttta aaggcaaaaa gtgcttttac

165841
aataatattc tttgtgaatg gaatttacac tcttggcatg tgttgccttt tcaatatgcc

165901
catcaagttc tgaataataa cctttgacag tgagtgaaca gaaacaaaac cagaggttgt

165961
ttcatctgtt cacagcaaca ctgtttgtca tctttgcttt tttggaaaaa tgtcattcca

166021
ccttaaataa aaatatgata aaattcatgt tttataagca agttaataga cttcgattat

166081
taagaaatat tttaattttt ccaaggcaag aaacctgtga tgaatgaaca ttaagttgac

166141
aaaagaaaaa aatatgccaa taaatatatt ttttcatatt actgtagtgt caaaaatttt

166201
ataaaacttt tatatgcctt tataaaaatg aagcaaagct aagaagaaga tgctgtatgt

166261
gttatggggt gaggaataaa cagaaaaagt gtcctttgtc ttggaaagaa ctgtaaaatc

166321
acctatctcc atgttgccaa agggaatcac atattgggaa atttaggcta tattaatata

166381
atacgtataa aaataattga aatagaaaag atctggcttt aagcattttt ctaaagactt

166441
tttcatgctt ggtaaaagtg tttggaataa attattctct atttttaagt agttaatttg

166501
gttattaacc taattggtat gggcatgtgg atatagcttt attaacaatt caatttctca

166561
tgaaataaaa taacccgaca aaccccaagt ctacttattg caatacagaa tttattttgg

166621
ttgaagttat tttgaattga gctgatagct tataactttg aattgggctt ataactgtta

166681
tgttttgcaa atccctgaag attatgaaat agaaaaatct ttgcatggca ttgtataaga

166741
tgctgtagct gtatatcttt aataaatcgt gctcattttg gcaagtttat ggaaaaattg

166801
tattaactgc acaaaaacat tatgataaaa acaataaaag taaaaaccac ttactaacaa

166861
ttgtacaggc atttaaataa ttgctgtact gttttctttc ctcaacagta caaatcaaag

166921
tggaggaaaa agaagacgag actgaggaaa gctcaagtaa gtggtgatgg gccacttggg

166981
atacatttcc tatggaatac cagtaaactc aaagaattta tcctcttgtg gacttgagct

167041
accatatgta agcagaagtg tgtgtggata acttttcatg gtctcacagg aggaatcaag

167101
ttcagcaaac agaatcccca ctctagagtc tatccagttg gcactataag ggccaagact

167161
gtgttccctt gattgcttgc tgaaaaatca acaagcaaaa gacatgttaa taggagaaaa

167221
ggcatataat ttcatagaac ttgtattcat taaagcctta ggatgaagac ccaaagatag

167281
agaaaattgt ccatttttat gcttaggttc aacaaagtgt ggatagcagt gtagaaatat

167341
gattggacga aaagggtata atctaatgtt tacatagagt ggggaaacac aacaaggcct

167401
gtctgcctag attcttcttg gcctctctaa gcatgcattt ctttcttctg ggtatggggc

167461
agggaccctc tttggaatga gggtcttatg atctacactc aaacaaggta ggtcggatga

167521
tttcttgatg accagttttt acacagacag ggcagaggga atgttagagt agtattttta

167581
ggtttcatgc atttgagaag aatgtttatt ctgttgttat tgggtagaat gttctgtata

167641
tgtctgctag gtctgtttga tctataatgt tgttcatgac tgctgtttcc ttattgattt

167701
tctgtctaga tgttctatcc attatggaat gtaatgtagg gtattgaagt ttcctactat

167761
aattatattg ctgtatattt tctctcttga gtttggttaa tgtttatatt taggtgctct

167821
gatgttggat gcatatatac ttataattgt gatatcttcc tggtaaattg acccttttat

167881
tactatttaa tgcccttatt tgttgcttat gacagtttta tactaaaagc atattttgtc

167941
cgatgtaagt atagccaccc ctgttctttt ttagctacca tttgcatggc ctatcatttt

168001
ccgttccttc actttcaccc tatgtgtgtc cttaaatcta aagtgaatct tttatagtta

168061
gcatacagtt gtttcttttc tttggtttct tttttaattc attcagccac tttatgtctt

168121
ttgattgaga agttcaatcc acttaaattt aaagttatta ttgatagagc aagactaact

168181
tttgccattt tgttcattgt tttctgtctt aaagctcttt tgtccctttt ttatctcatg

168241
ttattctcct tcatatttta ttgattttta ttatagtgat atactttgat tcctttctct

168301
tttcttttgt gtgtcttcta tagaaatttt attgtggtta ccatgggact catgttcaac

168361
atcttataat tataaaagtc ctattttaag tagaaaacaa tttaacctca attgcatact

168421
aaaactctac acttctactt tccttgacac ttaatattat tgacatcttg agttacatat

168481
ttttatatta tgcatccatt aacgtatttt tatagttact gttaatactt ttttactttt

168541
ataatacaat taaaagttac caatatactg tcattaaagt attatagtat cctgtatttg

168601
tctacatatt tacctttacc agacagtttt atattttcat gtgattttgt gttgctcttt

168661
agtgtcctct cttttcaact tgaagaactt cctttagcat tacttgtaag aaaagtctag

168721
gggtgattaa cttaggtttt gtttgtctga gagtctttat ttctctgtca tttataaagg

168781
acaaacttgc tgagcatagc tttcttggtt ggcaggtttc ttctttccaa cacttttaaa

168841
atatcatcct actttcttct ggcctgcata atttctgcta agaaatgata gtcttatgaa

168901
ggtttccttg tacatgacaa gttgcttttc tgtttctttc aaaattctgt ctttgtcttt

168961
gacttctggc aatttaagta taatatgtat tggtgtggat ttatttgggt tcacataatt

169021
tagggtctgt gggcttcctg aatctgaggg tccattttct ttcccagatt tgggaagatt

169081
ttggttatta ttttctttga atagtctttc tggccttttc tttcttttat tctccttcag

169141
aactcccata gtgtatatat tggtctgctt gttgatccct cataaaactt tcttgacttt

169201
ttcttattct ttttatggtt ttgctcttct aactataatt tcaaacatcc tatttttcaa

169261
tttggtaatt ctttcttttg cttgatcgag tctgcbgtta gacctctgta gtgaatttct

169321
gttactctat tcttcagtta ttgtgttcag ttattgtctt gtactcttca atatttatct

169381
ctggttattt ttatattttt atttctgttg aaactcatac tttgttcatg catttttctt

169441
ctgaatttgt tgagcatctt tatgagttat ttttaatagt ctgttaagta attcatatat

169501
ctccattata ttagggctgg tttctggagc tttatcttct gttgtttggg gtatgttttc

169561
ctgtttcttt atttttcttg attttgtttg tttgttttgg tatccatata ttagaaaaaa

169621
cagattcctt tcccagcctt caggagaagg attagccttg tacaggagaa gagtttcacc

169681
aatgaggcag gccagagatt cttgggcctc tcaaacattt cctgtgtatg catcgtctct

169741
ggacttgtgt gtgtaaattc tcaataagag ggatttttca gttgactttt tctttttaag

169801
aattcataat ctcttgttcc ctccagtgtc cttctgtcat aacatgtgtc ttctgaggaa

169861
gcagcatgtc ctgagttctt ttttttgttt ccagtagtcc ccaggcatca acagtatgct

169921
gggtcctgtc catgccctga gactggtcat tcccttaggc agcctcctga gaagtctgaa

169981
cacagggtat atatttcagt cttttatttc ccatttcagg ggcaagtcaa gggctggaat

170041
tcttgccaac tgtgtcatgc tgaactgggg gaaggggctc tggtgaatga gtacaaacta

170101
attcaaaact tcacctttgt tctccatggc cctgggccat ttagaatatg ctgggtccta

170161
ttagtgctct aggagacaag tgggacagaa gccagtccag tcatttttta gaaaagttgg

170221
agtgttagat gcactatcca actgtttttc tccccagaga ggtgcagatt tggtgtttat

170281
catctggtta ttctgtgcta aattggggga gtggctattt gagtgaggca tactattcaa

170341
acggctatct ttgctctcat tggttcctaa ccagaggtct tttcctgtca gtgctcagat

170401
tctggcaaga cagaaaccag tcctttggga acctccagaa aaatcagaat gttgaacaca

170461
tggttcagtt gttttctccc ctccccaggg agagactggg agatgatggt tttctcccag

170521
ttgtatggta ttgtgttagc agagagggat tatggtgtga gggtgtgtca gatttttcta

170581
ccagctacct agctgatttt gtgttcatct agggttcagg cacctttcaa ctagtttccg

170641
aatttctcac gaagggagct tatctccaca ttgtagttga acttttatgt ccatggaggg

170701
aaggcgggtc cagggcttcc tattttgtca tcttgttgat gtcatcccag tagtttagtt

170761
ttaatacaaa aaatactaaa attcagagta ccaagtagct gcttgggttt gtgagttatt

170821
agtgggtaaa ttgtttcttg cctcctgtca agtttttgtc ctttctttaa ttagtgacta

170881
atgtggctaa taaaagcagg gtaaatattc agaatgccat gatggggttc aaataacata

170941
catttgccac aatattaaac aaacagaaac tcgttcttga tttggatgac agaatatata

171001
tacagttttc caagcccagt tagaaaagtt attatgggcc gggtgcgata cctcacacct

171061
gtaatcccag cactttggga ggccaaggca ggtgaatcac ttgaggccag gagttcacga

171121
ccagcctggc caacatggtg aaaccccatc tctactaaaa atacaaaaaa ttagctgggt

171181
atgatggcgc acacctgtat tctcaactac tcaggaggct gagacaagag aatcgtttga

171241
actctggagc tggaggttgc agtgagccga gactgtgcta ttgtactcca gcttgggtga

171301
tagaacaaaa ttgtgtctca aaaaaaaaaa aaaagtgaag ttattctgtt ttttactctc

171361
tgctacctga catttagtaa tatatgtaat atttagatct tatacctgaa atatcaataa

171421
aaaagtttta acaagtggta attaaagata attttgaaaa aataaaatga tgactcacac

171481
gtatgtgaaa agaacatatt taactaataa aacaacttgt gagatgctat aatcagttca

171541
aaggaacgtc caaagaatag atacatttat agataataaa tattgaaatg attgtacaaa

171601
tgaaggcaaa gttgtttttg aaagggggct tgtctctcct ttggaaagag ttcatttgga

171661
tgtctacaga taaaaagtgt tttgtattgc tatatatggt tatgtataat tttcaaagtt

171721
gtcatatagt tctcataaaa tcagaatcag ataacacaga aaggtatgct gcagataatt

171781
catagttttc cattgaaata taattttttc tctggggtag cctctattta agagagtaat

171841
gataactgta atatttaatt ttttacagta gtttatgcta aatgttagaa gttaggagca

171901
atagaaatga aactggaata gtaatgttat gttataaact ttgtgaagga aattttatct

171961
taattatctt aatttatctt aattatctct ctattcttta cctggaagca tcctaaaaag

172021
ttatgaacac atgaggcatt cattgttgtt gatgatgaaa caaaataatg ctgtcattat

172081
tctcaatttt acattaaatt tatgttacct atttctattc ataagaaata aatgatcaag

172141
caaatgtgta tactactttt ttttttaaag aaaagaacaa aaatattgag gaaaaaggag

172201
aaaaatattt agaatcaaga atgaagaaaa tttaaattga gaggaacctc aagggttgaa

172261
tgaatttctc caaaattatt ctagtttgta gcacctcttt aacgttcctc ttctttgttc

172321
taagatagaa gtagtaataa atatgaagtg gttaatcact caacaattat gtaatggaat

172381
ggtaatctct aaacttggac ttatttgaat ggtcttagag gtcatggtat gatattaacc

172441
accaagctat ttagttactc aagtaaatga agaccagaac ttcttcaaaa acttattaaa

172501
atttgggaat ccacattcac ctatttgagt cggtgaacca caatggaaat ggaaatctag

172561
atacatttat ttaaatgatg ggctatgaaa tatgtattcc atgatgcatc ccatcacgat

172621
gtggagaatt gctagactgt gcbgtcagat gtgtaataat agttattaaa aactaagaat

172681
aagcttggta gtgggaggaa gcactttctg acattactca ttgaatcaag tgctatgttt

172741
aggtgaagag gaagaggagg tggaagataa gctacctcga agagagagct tgagaccaaa

172801
gaggaaacgg accagagatg ttatcaatga ggatgaccca gaacctgaac cagaggatga

172861
agaaacaagg aaggcaagag aaaaagagag gaggaggagg ctaaagagag gagcgtaagt

172921
tagttctgat attctttcaa aagttccaat gctgaagaag atcactcctt tcagatactc

172981
tttgacctta aaattggtaa ttaaagctac ttttagaaag agagccttaa tctgatgatg

173041
ctattttatt ctacttaatt aaatgtattt taatggttaa aatagaattt taaaatgaat

173101
atatattaaa aatggaccat gagaaattct cttatgaagg atctgaatta tcataggtcg

173161
ttgacatatt acagttaatt taaagatttt aaaatttccc cactaattgt atgcattgtt

173221
atctaggtta agtagaaact cctaaatagt gagcaaacat cactttatct tacagagcag

173281
gggttggaaa attatggcta aatccagccc aagaggtaag aatggttttt acagcttcaa

173341
agggtcatta ataaaaagca acaaatatgg gacagagttg tacatctcac tcaaagctta

173401
aaatattaac tatttggccc tttatagaaa gaaagtgtgc tagcccttgt tacagaggat

173461
ttgggttgtc attttctttt taatacaact caatatcttt tagttccacc aggaaaacat

173521
tttagtaaac gctgactttg tgtagaataa tgcattaaat gcbgtttagg aaaaatccaa

173581
gaaaatactt ttcttctttt tgctttttgg aaatttgcag atagcaggca ggtaggaaaa

173641
atgtacgtgt aaaacacctc taattaaaga gaaaacctag accccttgga aagaatgcaa

173701
gagaacagcc aacctgttcc acaactcaca ggtaataggg ccatgcgagt cgccatcagg

173761
tggtggaatc tcctccaaac actcctagga ctttgaagca tgaggaactt tctaagatgt

173821
cctcccaaga tgacacactt ctatactcaa tagctctaac tattgtgtta ttccttataa

173881
atgattgtca ttaaaaacaa ctgaatgaaa aatttgtcaa gtagagaagc ttagcattaa

173941
caaaaaatgg tttcttttag aataagaata acaccatcta cttcatgtct aagttttcct

174001
cctcctcttc cccagctttt cctttctccc ttttgaatac caagacaaaa cttgctttta

174061
aattttgact ctagtatttt ttatttatat ctgcttttaa agtttcttta tgctttattc

174121
ctttcaaaaa taaaatgcaa cacattttat gtcccatgta ttactatgat tgttagttcc

174181
attattatgt agtaatagtt cctatttagc aaagcttatg ctttccaaca gtggtatttc

174241
attgagaaaa catctccaat tgatgtatgc atgatatagg ttgtgttcca aaatttgctt

174301
ttcctctcta tttatgccgc aaaaaaatcc ttttaaaaag atgagttgga caggaattcc

174361
tctgctctct tcgtctgctg atggccctca tggcaactgc tcaacttcta ggaaatgggg

174421
ccatgtgaag caactggatc ctgtggctat gacagtgtct cttcctagct ggcctcactt

174481
tcattttgat cttgagaatc aagatccctt acctcccact cttccacata acccaactct

174541
ctccataggt tttgcaaatt gtatttttgc tgcgacaatt tgtgcatcta ttataaatag

174601
tatcagaaat tagttgtgat tattgatagt tctgttctct attttagagt ctattttcta

174661
ttgttcattt tgaagataaa catctttttt ttaaaagaaa atcttagata atatttttga

174721
gaaagattag tagccaaatc agggcacatt tatgtaggtt aattaattca gggtattttt

174781
tatttaacta ttcaagtaat gcctcaggga atttcccttg cattgacaca acatttgaaa

174841
ccaactaaaa ccaaggttgt aatgctaact atctttggag gcagttaaaa aaacactgcc

174901
ttgttagaca ttttggagta tttccagtaa tattacaggc ttttcctgac ccagttttaa

174961
gtggataagt aatatattca tagcagtgag aaattcagca tattatgcct tcttcttcct

175021
aacaactgtt gtttaaatat atcaaactta agatagaaaa ccattcttgc acagattagc

175081
ctgaaaattt agatgaggca tgcctatgcc ttttaatatg attagccctt tctttgagtg

175141
attctagaaa agcaggtttc ctgtaatgct gattagaaaa gtattttaat taccttcata

175201
tttgagggta acttatgtgt caacaactgt accctgtaac acagcctgat cctcctggtg

175261
aaataaacaa ttaacaacag agacttaaaa gatataccaa tctggggtca tttagtacag

175321
gaataaacgt ctttccatac cataataatc tcagaggtag ttgttatatt ttagtgtact

175381
ttgagcactg ggtttatgat gataaccctg agcaatccag aaaagttttg tatacatatg

175441
ttcattcaat aagttattta cccagctcta cttttgtgca acctaatttg cttatatctt

175501
tgggatactt ggatatgaac atgtaattgc ccacaatctt gcaatcttca aaagtccata

175561
atatagtaag ggataggcca cttagataca aattattatg acataagaaa gtatatgtgt

175621
cccagagaaa tacaaacaaa gtagcttgga gtctcagaga agtgaaaact gttctcacag

175681
ggatagttag aaaagggatt cttaaagaca tttcatatga tttttaaagg acttgaaatt

175741
tggacaagct gaacttataa actatttaat tagtattaga attgtttcta ttaaagggtc

175801
tctgaaagtt ggcctgtagg tttagttacc tggcaaatcc acacatcaaa tagataattc

175861
tttcattctt tggtgatgtt ggattagaga tgcbgtttta catgtgattc ttaatggaag

175921
ttcagtagtg taaagcttta aggtaattat atgtaaatat catgaattat tttgaaatgg

175981
ttggcaagtt aaaggcttaa catatcaagc aattaaatta ttaatcataa agattttttc

176041
taattgactt tattactgat aatttcttgc catctgtttt attttatttt tgctagtttc

176101
tgaaaatatt tcaataaaac tgctatctat gtaatttaaa gttattccta tgtttgcatg

176161
gaaacaattg tgatcatttt aattaaaaca catctttacc tcctaagaca aactaaccca

176221
catatcattc taattggcaa attaaaaaaa aaaattgtgg atatagatag agtaaaaaaa

176281
atcctgaaat attttatgcc atggctacac agcatcatag gcttttatat gataaacacc

176341
aaataatgaa aatagaaaca acccaatggc tatcagagat gtatcttaga agagtgtact

176401
tccctggttc tcttgaacca aaatgattat tctaagcaaa atgtttgaat tgtccaaaaa

176461
acaaactgtc aataggaagt gttattttaa agggttaata tgaatttttg tttcagtaat

176521
catagcatga ttaaaaacta taaattggtg gcaaataaag gagattgaaa gtcattttgt

176581
aaggtgaact ataaaactgt ggatatgtcc ttttcctcaa ctagaacttt aaaaagcagc

176641
ttttgcctta tttctactgt atctagtcat aaattatttt tctgagtaat actgaattgg

176701
attacaattt ttgttattgg tcaatatcta gtgaggggag aaacttcaac agttaattga

176761
acagagagaa tttaataagt gaattgttag gaggtataaa tgttaattag actgcagaaa

176821
aggtaaaaag agaacactaa agtatcatag tgacggtaac tactggaagc agctaccatc

176881
ccaagggctg gaggaacaat ggaaagggtt gaaacgaaaa cactgtagcg tagaggaaag

176941
accctaggag ctaaaactca ggcctctgca gaggggctga tgctctgtgg tgctggtttc

177001
tgtgggagag gtgatgaagc tggttctgct agtgttggta atattggtga taaggattca

177061
cttgcagtat ggcaaggacg ctcagctcca ggagtgaaga agagatgcta aggaggaagt

177121
gtcaccccac aaagcaaata tgaagcagag aggaagccac aggaaagacg gagaccctct

177181
tcagtatccc ctattgtcag agtatatatt gacccagcta acaaagcaga aatatgactc

177241
acaaaatacc agccccagca ccacaatatt aaagtgtagg agggtgtgtt tgaagttggg

177301
acaatagctt aaaaactgaa ataatctatt accaaaaagc tgatctctac aatgtggtat

177361
tgcatgcctc gatttaaaat tatgttgctc ttgtttagat tttgtttcct ttgagttctg

177421
gaccgcatag tgttttcgta atactaggaa cacagaaaag aaaagctaca tctcatgctc

177481
agtaggaact aaattccttt gaagatctct tcaaaggatt cacttccacc aaatatattt

177541
caaggtgaat tttaccaaat gaagttataa gtttaattaa cagataacat taagttacct

177601
ttgagaaata gatttttatt tttcccgatt tcaatttttc tttctttctt tctcttgaga

177661
cagggctaac aaaattttta agggcaaaga catcttcacc cctaatttat tatccttatt

177721
gagaaataaa atatttaaac gaaatgtaga attgagggaa ggtattcaag ggaacaaaga

177781
agagagggaa atatcttgat atatctgtaa ttattctttc cacagatttt ctggttcaga

177841
gagtttgagg ctctagacat aaaagaattg cttagggcgg gtgcggtggc tcacacctgt

177901
aatcccagca cattgggagg ccggggaggg tggatcacct gaggtcagaa gttcaagacc

177961
agcctggcca acgtggtgaa actctgtctc taataaaaat acaaaaatta gccgggcaag

178021
atggcagatg cctgtaatcc cagctactgg ggagcctgag gcaggagaat tgcttgaacc

178081
tgagaggtgg aggttgcagt gagccgagat tgtcccactg cactccagcc tgggcaacag

178141
aacgagactc tgtctcaaaa aaaaaaaaaa aaaaaaaaaa gcccggctta tgcctgtaat

178201
cccagcactt tgggaggccg aggtgggcag atcacctgag gtcaggagtt cgagaccagc

178261
ctggccaaga tggtgaaacc cccatctcta ttaaaaatat aaaaattagc tgggctaggt

178321
ggtgggcgcc tgtaatccca gctactcggg aggctgaggt agattgcttg aacctgggag

178381
gcagaggttg cagtgagcca agatcgcacc attgcactac agcctgggtg acaagagcaa

178441
aactccatct caaaaaaaaa aaaagaaaag aaaagaaaaa aacagaatgg cttagattca

178501
gattcaggaa ggcaaacact actgcttaaa gttataatag ttccagtaat cctgcatcag

178561
tgttcagatt tgagttctca tgcttatggg tcctaatgtt gactgcatat ggttacattt

178621
aaaaaaaatg agctaaatat ctgatacctg ccttccttaa gttccaaagt caagcaaagc

178681
ttaactttat taaggtgttt cttttttact tttaaagaga agaagaagaa attgatgaag

178741
aggaattgga aagattgaag gcagagttag atgagaaaag acaaataatt gctactgtca

178801
aatgcaaacc atggaagatg gagaagaaaa ttgaagttct caagtatggt gccacttttt

178861
ataagtagaa acactttccc tgatattgat tttctaaatc ctctgaatat tccatatata

178921
tatatatata tatatatata tatacacaca cacacacaca tacacacaca cacacacaca

178981
tacactgtat atatagtata tgtaatacta tatatatcat ttatatatga ctcattatat

179041
ataatggtca cagtcataaa catgtatatc atatttctgc atatataccc aaatatatgt

179101
atatttacat atatctgttt cttatcacta gagagactgg gctaatgatt ataaattgga

179161
agcaactctg agaaattatt tagagtcttt taaattcttt ggtcatcttt aatcatttgt

179221
tccttaaact ggagtttcct tagcttaata catttgttac catctctttg aaagagataa

179281
tatatttgaa ttttacaagt ttgtgtggat tgtgcactct tgtttctctt cagggccctg

179341
gtctcaaatg aacttttcat gtgacagctt acattaaagc acagagaaga tgctaggcca

179401
acagaatagt aaataggatt ccaattaaag gttatgctaa tagctattcc ccgaacatgt

179461
cagtgaccca atttcagtct tatgttgatg ctaatgtgga cgcgaacgca gtcagagcac

179521
acagatttat aaactcttca tatgaaaagt caaatgatta tcctattctg ggggatggga

179581
agattcaccc ctgaggatca cactatattt ccctgccctg gtggttggga gaggaggaaa

179641
gggcagggaa aagggaaact gtttgtgata acagccatgt ttgcatctcc tagttttgcc

179701
aaagattgca ttcttccata aatcattttt ataaatagta gtaagtttta aaaactatcc

179761
cttcacaagc ctatttaact agtaatgctg taaaaatgat agtatagtat tattgtctct

179821
gatgatgaaa acaagaactg aaatagctat caggataatt cacttctagt cttggttctg

179881
caagagcttg tgtgctattt aaaggtatcg cttaatctcc tgaagcctta gttacctcat

179941
atccaaaata aagaaagata ttctatatct tctctgtgcg cttgaagcgt agccatcatt

180001
tatagtattt ttgttttgtt ttgtagagta aggttttcca agttctaaac aatggttttc

180061
ccagaaaact tttgcaacac cacaaaattg cagtctggga actccctttg catgctcatg

180121
tacacatcca tcataaatga aggcaaaggc aagcagcatc ctacgttcca cagagctaca

180181
aattttgtgt atgcatgctc atgtgtctgt acattaaaat aattttcatt tagcgaagtg

180241
ataatgatgc taaattatag gttttaaaaa tattcttacc tggcaaaata gaagtttggc

180301
aaccctatgt gggcctctca aatatatttg aaatattaat gacccataaa gtccccaaac

180361
ttgggaactt cagataacta tatatagaaa gtttaaaatt ggagcaatat tgtgaacttc

180421
caaaatatat gattgaataa aaattccaag gactaccttt cctttccaac tgcatggagg

180481
tgtagaaata cccccctggt ctttgcccgt atctctcgtg caggatcgtg gaggagacag

180541
cagcttcaga tttgagttag gatctcagat cttccattta atagctgtgc acatttgatc

180601
gagttgtgta gtctctctac acaactcagg ttccttatga aattgtacct tattgacaga

180661
gtttttggaa ttataaaatg agataattta tgtaaaacat gttgccagaa cttggcacat

180721
agcbgggaaa cctaagttgt agttattact tcatctcaga acagacttga tgcccaattc

180781
ctgaagggtg acaagagaga tggagagaat ttgggacctg gcaagtctag gtgggagcag

180841
acctagtcac aatcagaccc cagaagcctt gtgggatggt gacacattgg taccagtttg

180901
gataaacaat aagattttga ggatgcaaca gaaggaagta aggcatttga caatttagca

180961
aaatccagga ccagaccgtt ctcagatctt ctaaaacata gccatagttc tgtggcagat

181021
ttcaaggtct caggccttgg tctggagtcc aagagttaag caaattttag caatggggag

181081
agataggcat tagcattgga aagaaggaca atacgagccc ttagtacgaa agcagacact

181141
gacaataagg agaccgcacc tgactctaat ctagacatag gtttttttat ttggcccaca

181201
tgtgttttgt ttctttttct tttatttttt ttaaccgtgg caatatatac aatacaaaat

181261
tcaccatttt aaccatgaaa tcgattttct ttatcataat ttttttcaat atttttaaaa

181321
atttaaatta cttttttttt ctcgagacag ggtcttaact ctgttgccca tgctggagtg

181381
cagtggtgct atcttagctc actgcagcct caatctcctg ggagcaaggg atccttctgc

181441
ctcagtctac cacgtacctg ggactatatg tgcacactac catgtttggc taattttttc

181501
tttttgtgta gggatggggt cttactatgt cgcccaggct gatctcgaac tcctggcctc

181561
aagccatctt cctacctcag cctcccaaag tgctgagatt ataggcatga gccactgcac

181621
ccagcctcaa tcttttaaaa gtgggagtaa aatattcaga tgttcagctt ttcatgaaca

181681
agtggaagat ttggtcctac attcttccat cacagtaaca gctaggacta agcacctggc

181741
ctctattaat ggggcattcc tttttcaatt tgcaccattc tcaaacaatc catattactt

181801
gtttatgctg cttggctgga ccctgtagac attcagattt gctgcctcct accagtgcag

181861
ctggggaaca agctaggcat gttaccaaga cggtgattca gatcttcaaa gccaaagtca

181921
gctcacagaa tggaagcaca aatttagtcc cagaaaagaa acaactgtgg cttctcacat

181981
gtcagcaagg ctcacagtct ggtgatgatt ttccatggcc agaagtggtt tctgccttgt

182041
ggccgcacct atgggttcca gctggtgcca tggccggggc cagcctaatt cttttggttt

182101
cagtctccgt gatgaagttg ttggtactta agtgcctgac ttatctctct ttgaatgctc

182161
tattgagctt tttttgaatg ttctattgag cttctcccca ccagattcca actacattat

182221
tagaacaagt ggtcagtact tcacagaacg tgcaggtaaa tgtttctcta ccccaatgcc

182281
accaatgctt gggagtgagg cagctttccc tctacccttt atttctttca gagacatcta

182341
actttgagag cgtgtttcta aggattatgt tattaatatt ccccaaatta gcctgcatca

182401
tcgctcctgg ctaagtctgt gaaacccaag atactaagct cagtgtaact gaaagagatg

182461
ttttgatcac agctttgaat ctgtgcctgg gttcgaagcc ttcttgttct ggacttggag

182521
aaagttttga aacttctaaa agatatttta gacagtgtca gggttttaag atatatttta

182581
gagtaagcct caggaatggc aacttatggt tctgagggtg ttatgggaga ctcagagata

182641
gttcccacat ttttaaagag catctaccat taggaacccg agcacactca gggcttagga

182701
tcaaaagatg gttaatataa gtggttgcta cataggcagg cagctctagg aattggttgt

182761
gaatccatat taatcctcaa acatggctca ggagctagag ttcagcattt tcaagatagc

182821
agaattggct ctatacagct gaaaggaagc catctccttt tcatcatcac tgtggaaatt

182881
gtgattttca ttctatgttt tattgtatat caatacaatt tcacacattc ctgtagcctt

182941
aaacctactg aatgataatc tcttggtgga aaggcaggtg tgtctggccc agaccagaaa

183001
tgtatatttt tattttttga tctaaaaatt actgatatat agtcagaatg aaagctgctg

183061
ttttcaattc tgagagacag aaagctccac taaacagaat actcagctct acagatgatt

183121
tatacaatga ggaagagtgt gtgtagggag ttggaggggg gtaagggaaa cagtgtcata

183181
ttttccaatt atttgaaagt caatttctat attttattaa tcacatcatt taaaaatatc

183241
cattaatgag aatactaagt ataatctgtt tttaagctgt tcatgggttt aattcagagg

183301
ctgtatgact agatctttcc tacctataag aggtcgcagc acttacctga tagcagccac

183361
cacaagtgaa ataaaatacc caggtagaaa gtaacaggtc tacttattac ttgtcttgaa

183421
acctaagact tttaactgta tcagaacatt atatgtggta gattgaaagt gctcatgact

183481
aaacctaaat aagcaaccac cttattttgt tacagtagaa taggttttag actgaaaatt

183541
gagacttgga ctttgagcta agtgcttcct ataacttctc tttgaacctc catttattca

183601
tttataaaac agataaattg gattgtggac catggtcttc aaactgctat cctccaaagt

183661
caagcagttt ggtgaaatca aatcagggca aaggaggcag aggtcgcagg gagagctact

183721
gggccacaat gccggcttca aaaacagacc tatggtttct ctcttctaca cagtgtactt

183781
ccatataaag cattgattgg aagaaagaat gcttctgtgg ctattaaaat aaaaaacagt

183841
tttaaaaacc cacttagctg gatatttaaa gaaacttatt ttggagaagg gacagttcta

183901
acatttcatg agtctacaaa ttaggataca gaaacactcc aagtatactt ttgcagggaa

183961
ttggcttttg gatagacacc attttaaaat gatttatttt gataacaaaa atgtttattt

184021
agctattata ctgactactt taatttctga gctttgtagt accctgacct attgtttctg

184081
ggagttgtcc attggctggc taggcctggt gatttattaa tgagacaccc agtaaagcca

184141
ggaaagttat cctcagattt cattcacact taaacaggtg cttcaaactg tcagctggcc

184201
attaaggtaa cattcctcct tactcaatct cccttgatct tttcacactt cttttcattt

184261
gtttgtttgt tttttatttt gttttatttt ttagttggga gaatgaatac atttttagga

184321
aagtgaaaac agaccatggt tgatttcctc taatggagct gttgggaaaa ctttgggaaa

184381
actatttatt tggcttccat tctcaccctt tctctcctgt tttcttgtag cttaagattt

184441
tcacaggcaa gaatcatggt ttatacttta gtttttctct catctgtcat tgtgaaggaa

184501
taaaagatgc tatacaagag gacatttaag cgtgtgaaca cacccaccaa cataccctca

184561
aaccattctg gattattttc ttttttaaat tttatatttc cataagtttt tggggaacag

184621
gtggtatttg gttaaatgag taagttcttg gggaacaggt ggtatttggt tacatgagta

184681
agttcttctg tgatgattta ttagattttg gtgcacccat cacctgagca gtatacactg

184741
aacccaattt gtagtctttt atccctcatc ccaatcccac cctttcccca gagtccccaa

184801
agaccactgt atcattctta tgcatttccg tcctcatagc ttagcttcca cttacgaatg

184861
agaacatatg atatttggtt ttccattcct gaattacttc acttagaata atagtctcca

184921
gttgtatcca ggttgcbgtg aatgccaata tttctttctt tttctttttc tttctttctt

184981
tttttttttt ttgagatggg atcttgctct gtcacccagg ctgtagtgca gtggcgtgat

185041
ctcggctcac tgcaaccttt acctgccagg ttcaagcgat tttcctgcct cagcctcctg

185101
agtagcbggg attacaggca tgtgccacaa cacccagcta atttttgtat ttttagtaga

185161
gatggggttt tgccatgttg gccaggctgg tcttgaactc ctgacttcgg gtgatctgcc

185221
caccttggcc tcccaaagtg ctgggattac aggcgtaagc caccatgcca ggcccaaatg

185281
ccaatatttc actccttttt atggctgagt agtattccat catgtatata taccacaatt

185341
tctttatcca ttcattgact gatggacatt tggtctggat tcatatttct gcaattgtga

185401
attctgctgc tataaacatg catgtgtaag tatccttttt gtttaatgac ttcttttcct

185461
ctgggtagat accctgtagt gggattgctg ggtcaaatgg tagttctact tttagttctt

185521
taaggaatct ccaccctgtt ttccatattg gttgtactag tttacattcc caccagcagt

185581
gtagaagtgt tcccttttca ccacatccat gccaacatct attatttttt gatgttttga

185641
ttatggccat tcttgcaggt gtaaggtggt attacattgt ggttttgatt tccattttcc

185701
tgatcattag tgatgttgag cattttttca taagtttttt ggtcgtttgt atatcttctt

185761
ttgaaaattg tctattcatg accttagccc actttttgat aggactgttt gtatttttct

185821
tgctaatttg tttgagttct ttgtagattc tggatattag tctttgtcag atgtagagat

185881
tgtgaagacc ttctccctct ctgtgggttg tctgtttact ctgctgactg ttccctttgc

185941
tgtgcagaag ctctttagtt taattaagtc ccacttattt atctttgttt ttgttgcatt

186001
tgctttgggg ttcttggtca tgaagtcttt gcctaagcca atgtctagaa ggttttttct

186061
gatgttatct tccagaattt ttatagtttc aagtcttaga tttaagtcct tgatccattt

186121
tgagttgatt tttgtataag gtgagagatg aagatccagt tttattctcc tgcatgtggc

186181
tagccaatta tcccagcaac atttgttgaa tgaatagggt gtcttttccc cacattatgt

186241
ttttgtttgc tttgtcaaag atcagttggc tgtaagtatt tggatttatt tctgggttct

186301
ctattctatt ccattggtct atgtgcctat ttttatacca gtagcctgct gttttggtga

186361
ccatagcctt atagtatagt ttgaaggaag gtaattggat gcttccagat ttgttctttt

186421
tgcttagtct tgatttggct atgtggcctc ttttttggct ccatatgaat tttagaattt

186481
tttttctagt tctatgaaga atgatggtgg tattttgatg agaattgcat tgaatttgta

186541
gattacttta ggtagtatgg tcattttcac aatagtgatt ctacccaacc acattagcat

186601
ggatgtattt ccatttgttt gtgtcatctg tgatttattt cagccatgtt ttgtagtttt

186661
ccttgtagaa gtatttcacc tccttggtta ggtataatcc caagtacttt tttttttttc

186721
ctgtggctat tgtaaaaggg gttgaatagt tgatttgatt ctcagcttgg tcactgttgg

186781
taaacagcag agctactgat ttgtgtacat taattttgta tcctgaaact ttgctgaatt

186841
catttattag ttccaggagc tttttggagg agtcttcagg gttttctggg tatatgatca

186901
catcatcagc aaacagtgac agtttcacct ctttaccaat ctggatgccc tttatttctt

186961
tctcgtgtct gattggtctg gctagtacta tgttgaatag tagtgagagt gggcatcctc

187021
gtcttgttcc agttctcaga gggaatgctt tcaactattc cctgttcagt attatgttgg

187081
ctgtatgttt gtcatagatg gcttttatta cattgaggta cgtcccttgt atgccgattt

187141
tgctgagggt tttaatcaaa atgggatgct ggtttttgtc aaatgctttt tctgtgtcta

187201
tttttttttc gggggggtgg gtgtttaaga gcagaaagtt taataggcaa aagaaagaag

187261
agaaaaccac ccccatgcag agggaggggg atcctctctt gctgcatcta ttgagatgat

187321
catgtcattt ctgttttaat tctgtttatg tgttgtgtca catttattta caagtgtatg

187381
tcaaactatc cctgcatcca tggtatgaaa ttcacttgat catagtggat tatctttttg

187441
atatggtgtt ggatttggtt agctagtatt ttgttaagga tttttgcatc tatgttcatc

187501
agggatattg gtctgtggtt ttcttttttt gttttgttct ttcctggttt tggtattagg

187561
gtgatactgg tttcatagaa tgatttaggg agtactccct ctttctcttt cttgtggaat

187621
agtgtcaata ggattgaatg tctgatagaa ttcagcbgtg aatctgtctg gtcctggact

187681
tttttttgtt ggtaattttt aaattactat ttcaatttca ttgcttgtta ttggtctgtt

187741
cagggtttct aattctgatt ctagctaaat cctcctgatt taagctagga ggattgtatc

187801
tttgcaggaa tttattcatc tcttctaggt tttctagttt atgtgcataa aggtgttcat

187861
agtagccttg agtgatcttt tgtatttctg tggtgttggc tgtaatatct cctatttcat

187921
gtctaataga gcttatttgg atcttctctc ttctttgctt cattaatctt gctaatcgtc

187981
tatcaatttt atttatcttt tcgaagaacc agctttttgt tcaatttatc ttttgtattt

188041
ttgttgttgt ttcaatttca tttagttctg ctctgatctt tgttatttct tttcttctac

188101
tatttgggtt tggtttgttt ttctagttcc ttgaggtgtt accttaggtt gtctatttgt

188161
gctctttcag actttttggt gtaggcattt aatgctatga acttttagca ccacctttga

188221
tgtatcccag cagttttgat aggttgtgtc actattattg ttcagttcaa agaatttttt

188281
catttccatc ttgatttcat tgttgaccca acaatcattc aggagcatgt actttaattt

188341
ccatgtattt gcatggattg gaggatttct tttgatttcc aattttattc cactgtggtc

188401
taagagagta cttgatacaa tttcagtttt cttaaattta ttgaaacttg ttttctggcc

188461
tgtcatatgg tttatcttgg agaaagttcc atgcactgat gaatggaatg tatactctgt

188521
ggttgttggg tagaatattc tgtaaatatc tgttgggtcc atttgttcta ggtatagttt

188581
taatccattg tttctttgtt gactttctgt cttgatgacc tgtctagtgc tgtcagtgga

188641
gtattgaagt cccccactat tattgtgttg ctgtctatct catttctgag gtctagtagt

188701
aattgtttta taaatttggg agctccagtg ttaggtgcat atttatttag gattatgttt

188761
tcctgttgaa caaagccttt tatcatgatt tagtgtccct ctttgtattt tttaactgct

188821
gttgctttaa agtttgtttt gtctgatata agaatagcta ctcctggtca cttttggtgt

188881
ccatttgcat ggaatgtaat tttccaccct tttacctcaa ctttatgtga gtccttatgt

188941
gttagttgag tctcttgaag acagcagata cttagttggt gaatactttt tttttaaatt

189001
atactttaca ttctggggta catgtgtgga atgtgcaggt ttgttacata ggtatacaca

189061
tgccatggtg gtttgctgca cctgtcaacc cgtcatccac attgggtatt tctcctaatg

189121
ctgtccctcc cttagctccg catccccaaa caggccacag tgtgtgtaca tgtgttctca

189181
ttgttcaact cccacttatg agtgagaaca tgtggtgttt agttttctgt tcttgtgtta

189241
gtttgctgag aatgatggtt ttcagcttca tccgtgtccc tgcaaaagac attaactcat

189301
ccttttttat ggctgcatag tattccatgg tgtatatgtg ccacattttc tttatctagt

189361
ctatcattga tgggcatttg ggttggttcc aagtctttgc tattatgaat agtgctgcag

189421
taaacatacg tgtgcatgtg tctttacagt aaaatgattt ataatccttt gggtatatac

189481
ccagtaatgg gatggctggg tcaaatggta tttctagttt cagatccttg aggaattgcc

189541
acactgtctt ccacaatggt tgaactgctt tagactccca ccaacagtgt aaaagcattc

189601
ctatttctcc acatcctctc cagcacctgt tgtttcctga ctttttaatg atcaccattc

189661
taactggcgt gagatggtat ctcattgtgg ttttgatttg catttctcta ataaccagtg

189721
atgatgagcc tttttttcat atgttggttg gctgaataaa tgtcttcttt tgagaaatgt

189781
ctgttcatgt cctttgccca ctttttgatg gggttgtttg atatttcttg taaatttgtt

189841
taagttcttt gtagattctg gatattagcc ctttgtcaga tggatagatt gcaaatattt

189901
tctcccattc tgtagattgc ctgtccaatc tgataatagt ttcttttcct gtgcagaagc

189961
tcttcagtgt aattagatcc catttgtaaa ttttggcttt tgttgccatt gcttttggtg

190021
ttttagtcat gaagtctttg cccatgccta tgtcctgaat ggtattgcct aggttttctt

190081
ctagggtttt tacggtttta ggttttaggt ttaagtcttt aatacatctt gagttaattt

190141
ttgtataagg tgtaaggaag gaatccagtt tcagctttct gcatatggct agccagtttt

190201
cccaacacca tttattgaat agggaatcct ttccccattg tttgtttttg tcaggtttgt

190261
caaagatcag atggttgtag atgtatggcg ttatttctga ggcctctgtt ctgttccatt

190321
ggcctatata tctgttttgg taccagtacc atgcbgtttt tgctactgta gccttgtagt

190381
ataagtttga atcaggtagt gtgatgcctc cagctttgtt ctttatgctt aggattgtct

190441
tggctatgca ggatattttt tggttccata tgaaatgtaa agtagttttt ttcaagtctg

190501
tgaagaaagt caatggtagt ttgatgggga tagcattgaa cctacaaatt actttgggca

190561
gtatagccat tttcacgata ttgattcttc ctatccatga acatggaatg tttttccatg

190621
tttgtgtcct ctcttatttc cttgagcagt ggtttgtagt tctccttgaa gaggtccttc

190681
acatcccttg taagttagat tcctaggtat tttattcact ttgtagcaat tgtgaatggg

190741
agttcactca tgatttggct ctctgtttat ctgtttttga tgtataggaa tacttgtgat

190801
ttttgtacat tgattttgta tcctgagact ttgttgaagt tgctaatcag cttaaggaga

190861
ttttgggctg agacaatggg gttttctaaa tatataatca tgtcatctgc aaacagagac

190921
aatgtgactt cctcttttcc taactgaata ccctttattc ctttctcttg cctgattgcc

190981
ctggccagaa cttccaatac tatgttgaat aggagtggtg agagaagaca tccttgtctt

191041
atgcbggttt tcaaagggaa tgcttatgct tccagttttt gcccattcag tatgatattg

191101
gctgtggatt tgtcataaat agctcttatt attttgagat acattccttc aatacctagt

191161
ttattgagag tttttagcat gaagggctgt tgaattttgt tgaaggcctt ttctgcatct

191221
attgagataa tcatgtggtt tttgtgattg gttctgttta tgtgatggat tacatttatt

191281
gattcgcata tgttgaacca gccttgcatc cccaggatga agccagcttg atcatgttgg

191341
ataagctttt tgatatgcta ctggattcag tttgccagta ttttattgaa gatctttgca

191401
ttgatgttca tcagggatat tggcctgaaa ttttcttttt ttgttgtgtc tctgccaggt

191461
tttgctatta ggatgatgct ggcctcataa aataagttaa ggaggattcc ctctttttat

191521
attgtttgga atagtttcag aaggaatgat accagatcct tttagtactt ctggtggaat

191581
tcatctgtga atttgtctgg tcctggactt tttggttggt aggctattaa ttgctgcctc

191641
aatttcagaa cttgttattg gtctagtcag ggattcaact tcttcctggt tcagttttag

191701
gagggtgtat gtggctagaa acttatccat ttcttctaga ttttctagtt tatttgcata

191761
gaggtattta tagtattctc tgatggtagt ttgtatttct gtgggatcgg cggtgatata

191821
ccctttatca ttttttattg catctacttg atttttctct cttttcttct ttattagtct

191881
ggctagttgt tgatctttca aaaaagccag ctcctggatt cattgatttt tttttttttt

191941
gaagggcttt ttgtatctct gtctccttca gttctgctct gctcttagtt acttcttgcc

192001
ttctgttagc ttttaaattt ttttgctctt gcttctctag ttcttttaat tgtgatttta

192061
gggtgtcgat tttagatctt tctttctttc tcttgtgggc ttttagtgct ataaatttcc

192121
ctcaacatac tgctttcaat gtgtcccaga gattctggta cattgtttct ttgttctcat

192181
tggcttcaaa gaacatcttt atttgtgcct taatttcatt atttacccag tagtcattta

192241
ggaacaggtt gttcagtttc gatgtagttg tgaagttttg agtgagtttc ttaatcctga

192301
gttctaattt gattgcactg tggtctgaga gactgttatg atttccattc ttttgcattt

192361
gctgaggagt gttttacttc caattacgtg gtcaatttta gaataagtgc gatgtggtgc

192421
tgagaagagt gtatattctg tttatttcgg gtggagagtt ctttagatat ccattaggtc

192481
tgcttggccc agagctaagt ttaagtcctg gatatccttg ttaattttct gtctcgttga

192541
tctgtctaat attgacagtg gggtgttaaa gtctcatgct attattgtgt gagggtctaa

192601
gcctctttgt aggtctctaa ggacttgctt tatgaatctg ggtgctcctg tattgggtgc

192661
atatatattt aggatagtta gctcttcttg ttgcattgat ccctttacca ttatgtaatg

192721
ctcttctttg tctttttttg atgtttgttg gtttaaagtc tgttttgtcg gagactagga

192781
ttggaacctc tgcttttttt tgcbgtccat ttgcttggta aatattcctc catcccttta

192841
ttttgagcct atgtgtgtct ttgcacgtca gatgggtctc ctgaatacag cacaccaatg

192901
ggtcttgact cttaatccaa tttgccagtc tgtgtctttt aattggggca tttggcccat

192961
ttacatttaa ggttaatatt gttatgtgtg atttgatcct gccattatga tgctggatgg

193021
ttattttgct cattagttga tgcgatttct tcatagcgtt gatggtcttt acaatttagt

193081
atgtttttgc agcggcbggt actagttgtt cctttccatg tttagtgctt ccttcatgag

193141
ctcttgtaag gcaggcctgg tggtgacaaa atctctcagc atttccttgt ctgtaaagga

193201
ttttatttct ccttcactta tgaagcttag tttggctgga tatgaaattc tgggttgaaa

193261
attattttct ttaagaatgt tgaatattgg cactgtcttc tggcttgtag ggtttctgca

193321
gagagatcta ctgttagtct gatgggcttc cctttgtggg taacccaacc tttctctctg

193381
gctgccctta atattttttc tttcatttca accttggtaa atctgatgat tacatgtatt

193441
ggggttgctc ttcttgagca gtatctttgt ggtgttctct gtatttcctg aatttgaatg

193501
ttggcttgcc ttgctagctt ggggaagttc tcctggataa tatcctgaag aatgttttcc

193561
aacttggttc cattctcccc atcactttca ggtacaccaa tcaaacatag atttggtctt

193621
ttcacatgat cccatatttc ctggaggttt tgttcatttc ttttcactgt tttttatcta

193681
atcttgtctt cttgctttat atcattgaat tgatctccaa tctctgatag cctttcttct

193741
gcttgatcga ttcggctatt catactcgtg tatgtttcat gaagttctcg tgctgtgttt

193801
ttcagctcca tcaggtcatt tatgtcctct aaactggtta tttcagttag caatttgtct

193861
aacctttttt caaggttctt agcttctttt cattgggtta gaacatggtc ctttagctcg

193921
gaggagtttg ttattaccca ccttctaaag cctacttctg tcaattcgtc aaactcattc

193981
tccatccagt tttgttcgct tgctggcaag gagttgtgat cctttggagg agaagaggca

194041
ttctggtttt tggaatgttc agccttttcg cactggtttc tccccatctt cgtggattta

194101
tctacctttg gtctttgaag ttggtgacct tcggcbgggg tctctgagtg gtcctttttg

194161
ttgatgttga tactattcct ttctgtttgt tagttttcct tctaaccatc aggcccctct

194221
gctgcaggtc tgctggagtt tgctggaggt ccactccaga ccctgttcac ttgggtatca

194281
ccggcagagg ctgcagaaca gcaaagattg ctacctgttc cttcctctga aagctttgtc

194341
ccagagggac atccaccaga taccagccag agctctcctg tatgaggtgt ctgtcagccc

194401
ctactgggag gtgtttccca gtcagtatac ctgggggtga gggactcact tgaggagtca

194461
ctgtgtccct tatcagagct ggaacccagt gttgggaaat ctgctgctct cttcagagct

194521
gccacacagg gcbgtttaag tctgctgagg ttgcacccac aaactcccct tcccccaggt

194581
gctctgtccc aggaaggtgg gggttttacc tatgagtccc tgactggggc tgctggcttt

194641
ttttcagaga tgccctggcc acagaggagg gaatctagag aggcagtttg ggtgcagtgt

194701
ccttactgag ctgtggtgag cttcgtccag tttgaacttc ctggcaactt tgtgtacact

194761
gtgagggtaa aaccccctac tcaagcctca gcaatggcag acgtccctcc ccccaccaag

194821
ctcgagcatg ccagatcgag ctcagattgc tgtgctggca gcgagaattt caagccagtg

194881
gatcttagct tgctgggctc cgtgggagtg ggacccactg agccagacca cttggctccc

194941
tggcttcagc cccctttcca ggggcgtgaa tggttctgtc tcactgacat tccaggcacc

195001
actggggtat gaaaaaacaa ctcctgcggc tagctctgtg tctgcccaaa cggcagccca

195061
gttttgtgtt ggaaacccag caccagggcc ctggtggcgt gggaactgga gggaatctcc

195121
tggtctgcag gttgtgaaga ccatgggaaa agtgcagtat ctgggccggt gtatgtggta

195181
cagtccatag tggcttccct tggctaggag agggagttcc ctgatccctt gcacttcctg

195241
ggtgaggcaa cgccccaccc tactttggct tgccctcctt gggctgcatc cactgtccaa

195301
ccagtcccaa tgaaatgaac tgggtacctc agttggaaat gcagaaatca cccaccttct

195361
gcatcgatct tgctgagagc tgcagactgg agcbgttctt gttttgccat cttgccagca

195421
aatcggtgaa ttgttatgta ttctgcaatt ctatatcttt taagtggagc atttaggcca

195481
tctgcattca atgttagtat tgagatgtga ggtactattc tattcatcat actatctgtt

195541
gcctgaatac cttggttttt tatttattta cttatttatt gtatttttgt tttaatgggt

195601
cttgtgagac tcatgattta gagattctgt tttgatgtgt ttccatggtt cgtttcaata

195661
tttagagctc ctttcagcag ttcttatagt gctggcttgg tagtggcaaa ttctcttggc

195721
ctttgtctga aaaagactgt atctttcctt catttatgaa gcttaggata caaaactgtt

195781
ggctgataat tgttttgttt aaggaggata aaaataggac cccagtcccc tctagcctgt

195841
agggtttctg ctgagaaatc tgctgttact ctgatagatt ttcctttata ggctacctgg

195901
tgcttttgcc tcacagctct taagattttt ccctctgtct tgactttaga taacctgata

195961
actataggtt taggcaatga tctttttgca atgaatttcc caggtgttcg ttgaacttct

196021
tgtatttgga tgtctacatc tccagcaagg ctgaggaagt tttcctctat tattccccca

196081
aatatgtttt ccaaacttag atttctcttc ttccttaggg actccactta ttcttaggtt

196141
tggtcattta acataatccc aaacttcttg gaggctttat tcatttttta aaattctttt

196201
actttccagt acattttgca tttctctgtg ttctttactt cctgaagtag tgattgtttt

196261
atatttatgc tatctatttc actgaagatt tctcccctca tatcttgtat catatttttt

196321
tatttcctta agttggactt cacctttttc tggtgcctcc ttgattagct tactactcga

196381
ccttctgaat ttttttttct ggcaattcag ggatttcata ttggtttgga tccattgctg

196441
gtgagctatt gtgatttttt gatgatgtta aagaacatta ttttgtcata ttaccagaac

196501
tgtgtttctg gctccttctt atttgggtag gctatttcag aggaaagatc tgaagctcaa

196561
ggctgctgtt cagattcttt tgtcccatgg ggtgttccct tgatgtagta ctctccccct

196621
tttcttagga atgtggcttc ctgagagcca aactgtagtg attgttattt gtcttttgga

196681
tctagccacc cagtggagct actggtctct gggctggcac tgggggatgt ctgcacagag

196741
tcctgtgatg tgaaccatct ttaggtctct cagctgtgga taccagcatc tggtccagtg

196801
gaggtggcag aggagtaaaa cagactctgt gaggtgcctt agttgtagtt gtttaatgca

196861
ctagttttgt gctagttggc ctcctgccag gaggtggcgc tttcaagagt acgtcagctg

196921
tggtagtata ggggaggatc aggtggtggg tgggggccct agaactccca agaaaatatg

196981
aactttgtct ttagctacca gggtgggtag ggaaggacca tcaggtggga gcagggttag

197041
gtacgaatga cctcagactc tccttgtgtg gggcttgctg tggctgctgt ggggataggg

197101
gtgtggttct caggtcaatg gagttatgtt cccaggagga ttatggctgc ctctgctgtg

197161
tcatgcaggt tgtcaggaaa gtggagaaag ctgatagcct cacccagctc ccatgcaacc

197221
caaaaggctg gtctcattcc cactgtgccc cctccaacag cactgagatt gttttcaggc

197281
agtgggcaag tagggctgag aacttgcccc aggttaccag cctcctggtt gagaaagcaa

197341
gcggggcttt tgtgccacct ccctgcctgt caccggattc acatcctccc ccaagttctg

197401
gccaggaaac ttcacatttg gttggaatcg ttacagagtt cagctggagg tttccttctc

197461
cctgtggtct tttcccagtt cctctggcag ccctcctcaa ggactcctgt gagacaagtc

197521
agaaattgct tctctgggga cccggagaac ccacatggct tttcctgtgg cttcttctac

197581
ccttgtgttt cactcagctc tctaaattgt ctcagctcca ggtaaggtca aatctttctc

197641
ttgtgatctg gacctttagg ttccccagtg agtgtgtata ttcggggcag gggatgatct

197701
ccctttccca cttttgcagt ttgggcactc acagtatttg ggctgtctcc caagtcctgc

197761
aggagcaacc tgtttccttc aaatggtctg tggattctct tgactttccc agtatatttc

197821
tgcagcagtt cttggaacaa aagttcacaa tgcaagtctc cacattctat tctatccatc

197881
caagtggggg ctgcaattta gtcctgactc ctatctgcca ttttttccta gcagttcatt

197941
ctggattatt tttaaccaat aactcaacca aagcacaggc cttcagttct tgtactttac

198001
aggtatcttg agtatagcaa tttttcatct gcagaatgga gagtatatag gcaattaatg

198061
catctagatt ttgtccatca aaaggtaaca ttgacatccc atttttctgc tattttataa

198121
gttcatacca ggtgtcaagc attatgctgt gggcaagttt cttagtctct acatccttga

198181
gtctccttac tatgaatgga gataaaagta ctactgcata aagttattga gataattaaa

198241
taagctcata gatacaagca tgtaacatgg tacctagcat aataattttc tttatccctc

198301
ttaaccctcc ttcaaggtag gttttactat tttgacttta catataagga aactgaaact

198361
ctgagaggat aaataattgt cagacaatta ataagtgata gatccacaat ttaagcttgt

198421
tgtgtggaaa cttaccttgg tatgatggag gtctctaagt acactaccaa gcaagctctc

198481
ccagaagtca caaacctgaa gttcacatac caaattaaaa tgctcaaatc acatggctta

198541
gtaagcttat ttaaagcaca gtgagaagta aggggaaaga gatgggttat ggtaagacat

198601
gggataaagt agcaatatcg tgagatcatg ggcaacagga ccacacttct gtatcctgtg

198661
ttctgcagtg ttcgtgtgcc ctgtctctct catcctgctg atagtgtggc taaggggact

198721
gaggtcccaa tgggggccac ataataaaga ttacttgggc caatgatagg tacaagctcc

198781
attggaatga atgacacagg acaagtacgc ctgatcatag cagtagcttg tgattagcct

198841
gctgaaattg caggagttgt gtctgcattt cttggacaga gcagatgcaa gaggaacaaa

198901
ctggatgaca ccaatggctg gtcaagttag cagtgacagg tatctcagtc ccaaagtgtc

198961
aggataatga tttggtcttt tcatctcttt ctaactgtaa tgttcttgtt tgttcatcat

199021
atatattttt aaaaatttat tttctgtctt tctttggcag atattacagg ttactaattt

199081
acctgctatc tgtagtgaac acatcaaaca tgcctatgca tcatatgtac atgtttactt

199141
attagctata tttaacatat cctatgtgca ggaccagcta cataatttgc atgatgtaat

199201
gtaaaatgca aatggggggc cccttgttaa aaaatactta agaatttcta ttattaagaa

199261
ttttaagatg atgaaagaaa ccagaatatg ccagctctaa atatgcctca ttgacgtaaa

199321
tatttttgag ctgaagggaa ttaagaagca catgcagaaa agctctctgc ctcttctatt

199381
tgcctaaaag caggacagag aattacaaaa acaaaaggtc ttttatgttc ctcctcccct

199441
ttcctgccta aagacaagat gtaaattctc ctttacaacc tttaccagct gagagcctgc

199501
ttcagaaaaa tctgggaaca gacttgactc tttcccacag ttctctggcc tttggaagct

199561
tagggcbgtt ttcctctttg tcctgtcact tctctacaat gtattgatct tgttgaatac

199621
tttgtattag ctgggattct aagccacact gccttgagtt acttttcacc tgcgtgatgt

199681
tcatgtatta atagacttgt ttgtttttct cttgttaatc tgtcatttgt tacaggagac

199741
tgtctcaatt aaaaacttac gagggttcag aaaaattata atttcttccc aacaatgaca

199801
atagcagagc ataaaactaa gcacagggcc catgtgagta tggggtcctg taacagtgca

199861
ggtcacaggc ctatgaaatt gcccctgcct atgaatttca cctgactatt ccaagccaag

199921
agctacttat tatctatgct gaacatttct aatgatttcc atcttttcca atagcagaat

199981
tcagtggtct caaataattc agccaactca cattatagaa ctcaagtcta tgtaactcca

200041
agtcactgtt catgcactat agtcatggag ttctttttaa atacctgtca tccccatgtt

200101
caaacccttc aatgtctccc tagtaattaa caaaatttag tcaattttgc ctaaaaaata

200161
tcggtgagct ccacaacctg aattccaact tactttccaa agcaaactct cattaattac

200221
tgatgatgac catgaggttt tggagaggga caaaaccatc tccaaatgtt tttgagtgtc

200281
tcctgtgtat cgtgtcctgt actagatgtt ttacacatca actcatttaa tccttatgag

200341
aacattgaaa acaaagttat ccccatttta cagatgagaa aattgagatt gatagaggta

200401
aggtcacctt acacagttat taactgtgag ggtggattaa aatccagatt tctctgtctc

200461
taaaacctca ggctttttct actgtgccat actacttcta atttgaactg tattttccag

200521
tgaaatgaga ttaatcttcc ctatagacat gccaggtacc tgttatcact ttattctggt

200581
atccgctcca ttttttggca tcctatgctt cttccatgcc tgactttatc tcccgtttga

200641
gcctctttct ctgccaacgc ccatagaaat aaaattcaaa tgaattctct tgattattca

200701
tttggctctt ctgttaggca gcattgtgtt gcatttttaa aaattatatg taaatctcca

200761
tttcagaaga gattttgagc tcctcagggc acgaaacgta tcacatagct ctttattgtc

200821
tcaagtacta gcatagtgct ttgtatgcaa tatttaatta atattttctg tgtgggtgaa

200881
aatgttaatg tcttttttgt tggacattca tttccaaagc agaacaatta acatgactgg

200941
atgtttaaag ggtctggatg aataggtgag tgaaggacag aaatgtgctg gtaaaaagcc

201001
ctgatctata gtgcttgcca atttccgtgg tgtaaatact tccactatag ccaattttaa

201061
gctaccaaca gttagagcca actcacaaaa ttcttgaaaa tttcataatc agtggttttg

201121
tgtgagccag cataagtcag cttcggtatc tctttgaggg atttaataat gaactcaact

201181
aaggtaaaac tgatctggaa caactgaaag cagaggttaa agtaaaataa ctctgttatt

201241
taatctataa tcaactatga aatgcttgaa ttagagctgc ctgtgagaag gaaaaacaat

201301
gattccataa tgtgaaggct ccagacaaag gccaaaagtg catcaatgac ttcttatccc

201361
agttttttaa actaaaaaaa ctgctagcta aatgattttt gttttatatg acttttgttt

201421
tatatgactt ttgtttatat gactttcctc ccaaatctgt tagcatgcat agagtttcag

201481
tttttctttc atcttctcct cttctgctca tttctctctt tttaaatttt atcataaagt

201541
ggaacacttt ttattcaaga gaaatcaatt cttgattgag atcagaaatc tcttgccatt

201601
cacattagag ttgatctacc acaattgcct gcttcatcat tttcattcta ttggaataag

201661
tatttacagc tataaactat cctgcatctt acatatttct attaaacaag aacaatgtcc

201721
gtgacagttt tctgtctcag gatttatctt attaatattt attgtattgt tatgagtgct

201781
tagcaaatta ttgtggttaa ctttaccaat gcctttcaaa taatattttg aaattttccc

201841
tgaaaggata ttgagaaaag ccaaatgtaa aaattattgt tttttttcct tgggatttgc

201901
atgttttgaa aacgttctca attgttaggg aagtcagctg taaaacacag gctaaatata

201961
cttttgtcta ccaagaattc cctttacttg tctgtttcgt gatttgttta atctttctta

202021
gttatgcatg taccatttta ccatagttac ctggagatat tcttgtctct gccttagttt

202081
ggcaggcttt tcaagtggct cactgagcta ctgtttctat ttcttttaga aagttgtgga

202141
ggcatttatt actctcataa ctgcctcaaa atctcaagca catggcctag ttaaatcatc

202201
ttgaggttct gcccatatgg ttgcagaagg atattagtca ttggaaaaaa tgggtctaaa

202261
atgataatat tcaaagatgt tttccaatat tcttggcaat cttattcact aatttccacg

202321
gacatttaat tagcaagaat ttaaagaacc ttgttttagt ttcctgctgc tgtaatagaa

202381
tatcacagac tggataatat ataaagaaag gaaatttatt gggcttatgg ttctggaggc

202441
tgggaagtcc aagaggcatg acactggcac ctggcaaggg tcatccaatg gtggaaggca

202501
tcacatggtg agcaaggacg agagacaggg agaaatgggg ctgtatttat ctttttatca

202561
ggagcctact ctgtgatact agcccactct catggtaacc acattaatac attcatgagg

202621
atagagccct catggccgaa ttatctctta aaggtcccat ctcttactac tgttacaatg

202681
gcaattaagt ttccaataca taaactttag gagacatagt caaaccatag aaatcttaaa

202741
cttcaaataa acagggattt tttttagtag cacagtataa aatgataata ataaatatca

202801
gatataaaaa atttctgaag ttctttttag atagataaat catggttact attatcttct

202861
tagttacatt tcattgcacc ctattttctg tggtattatc agtcaacata ttatatatag

202921
taagacacat taaattttct gagcttgcca gggcatcctg tcccctaaca gtttttgata

202981
atgatttatc aaatgtgtac tctttagaat tttagcbgtc agtaacagtt gattttcaca

203041
acttttatta gactatccat gatgtttttt ggaaaggtag ttaaaaggat aaatacatta

203101
attatcataa aattatctag gaatgctttt aaatacattt gacataatac attaacacta

203161
aaaggaaagc aaatatgcac ctaataagca caaaataaga ttaatcagag aaatgtgtcc

203221
ttgctgtttt ggggaagagt tatccagatc tcaggtaagg tactttttgt ggagataacc

203281
ttctgtttta tgaagcttgt aacaagataa caatcaaggc atttttgtgg ccatgtttat

203341
gtatatgagc aagcaatggc aagtgagata ctagtttggg ggcttaaata agataaaagt

203401
agttaaactt tattaaaatg cacatattaa aataaatttt gaaatacatt gtattcaaat

203461
attgtattag ggttctctta gacaactcat aggatacccc cacacacaca ttttatgtgt

203521
gtatgtatat atatatatat atatatatat atatatatat atatatatgt atatacacac

203581
acacatgcgt acatatatat acaggagttt attaagtatt aacttacatg atcacaaggt

203641
tccacaacgg ctgtctgcaa gctgaggagc aaggagagcc agtcccaaaa tcaaaactga

203701
agaacttgga gtccgatatt cgagggcatg aagcatccag cacaggagaa agatgttgtc

203761
ggggaggcta ggccagtctc tcattttcag atttttctgc ttggtttata gtcactggca

203821
gctgattaga ttgtgcccac cagattaagg gtgcatctgc cttccccagc ccactgactc

203881
aaatgttaat ctctctctct ttttttttga gacggagtct ggctctgtcg cccaggctgg

203941
agtgcagtgg cacgatctcg gctaactgca agctctgcct cccgggttca agccattctc

204001
ctgcctcagc ctcccgagta cctgggacta caggtggccg ccaccatgcc cggctaattt

204061
tttgtatttt tagtagagac agggtttcac tgtgttagcc aggatggtct cgatctcctg

204121
acctcgtgat ccacccgcct cagcctccca aagtgctggg attacaggcg tgagccacca

204181
cgcccggcct caaatgttaa tctcttttgg cagtacccac acagacatgc ctaggattaa

204241
ttctttgtac ccctcaatcc aatcaagttg acactcagta ttaaccatca caaatatcat

204301
aacaaatcgt gtgaaaggag gaaaggggaa tagttttaca tttcaaatat aaggggtcca

204361
agattccctt ttatagttat aaaaattaga aatttttaaa tggtatgaat cacttatttc

204421
aaatagttgt atttatgatg cttttgtaat atatatgcat aagtttacct atatatttat

204481
atatgtgtgc atgtacatat aatgtataaa tacacaaagg cactcatatc tacataatga

204541
tacatgattc tttggatgaa ttaactttta cattttatgc atacactctt attgtgtttc

204601
ttgaccagtg cttggtcaca gggatcagga caagttagaa gggaggctat gggaggacac

204661
tgtaaaatat taacacaact taattctgca gaaaggccag ttcacatagg aagatggtgt

204721
cctctgaggg tgcacttacc caagctgtgt tccccaattg cttaggacag tcttccatgt

204781
ctaagtttgt catgtggcaa acaatcaaat ttacctggta gtcctagtga tttgcagagc

204841
tcactgaaat gccatcgttt aaaagcatca ttttaaattt attgtccact gatagatcaa

204901
aagatagaat accctattcc aagagaaaaa ctaaagactt ctattagaaa aatttaggtt

204961
tagcacttct aaatatcact atacaacatt ttgaaaaatg ttttgaaaaa acagttataa

205021
tgcttagaaa catttagaag aatataagca cacaggtatt gtgttgaaac acattaccta

205081
cactttcaat gcaggatgct tcttctcact atggggcagc actttgtgaa tttttctgtt

205141
tcacagtatt cagaattcat tagaacatgt ttgattagaa tgcacatgag gcaagcaaaa

205201
ttagcacagt ctgtctatca agccacgtag atggccttgc aaagagctga atgctagtat

205261
atctaagaat atgagattat atgtatgatt catggtggaa atgtctcctt tgttagataa

205321
attcctgcaa accaatgcct ggaatgccct ctctgcctac tcgaattcta ttagctcttt

205381
aacatccatt tgaattctta tctcatctac aatatcttca gcaactctga agcctccatt

205441
gtcctctccc ttttcacttc aaggcbgtct tgcattgtta tgtaactatt tcatgggcct

205501
agatctcatt tttcttaata aagtttaagc tgtagaaagg aattcatata tttccttgat

205561
ttcttttaaa cacttaacac attaagaaca taaaacatac ccagtaatta cttaaagaaa

205621
aaaaagacta agtaaaaggg acaatgaaag aataatagaa ataaaatgaa tttgtttatc

205681
agccagaatt ttgggtgggt cctcctcata gctatgtata gcaatctata atttcagtgc

205741
tatttctacc tacttctaat aaaaatattc ccacagtaaa ggggcaaggg gaaattccac

205801
cattttgcaa cattttggtg attagaattg ttgagatatg gttttagaca gagtttcctt

205861
cttattcttg ggctggtgat tttaagattc atttgtgtgt tttaggtcac attctcccca

205921
aatctcattt ttgctcaaca caagaacagt aagagtaagc tgggatgcct tagtgatatg

205981
gcctggaact ctgcagccta cataatacta tccctacctt caggtattag tgttgctaat

206041
aacatgctca actgattcat taaaacaaag gacaaaaaaa taaacaaaca taaaatcatt

206101
ttcatagagc ttaaagagac tatccagaga gacatttata aagttaccat tataaaatgc

206161
ttcacactaa aaaagaattc tttacaataa tttggttgta aattgtgtaa aattcttttt

206221
ccctccatca attttagatt tattggttgg agccttgtaa gtcagactga caaaagacag

206281
attaacaaga gaaaaacaag cagaagttta ttaccatgta tatccctctt attcatggga

206341
gatgagtaac tgaaagagga ggttagaact tgagctcaca tagcatctta acaaaagaac

206401
agtacatttt taaagaagtg acaagacaaa ggaaaaggac tttgagtttc taggatggca

206461
aatgatggga aagcaaatat atgggggaac taatggaaaa taaggactat ttagtaaagc

206521
ttgtcatgca gattcctctg gtgccctctc ttgactgata agtctggaat agtcttcagt

206581
gattaacttc tgtccttcca ggtaagaggg gaatgaaaat aataccttta tatatttatc

206641
tcctgctttt aggcaaaggg ggagagcaga gagcttttct tgtatctgct gcttcttgat

206701
tgctttcatc ttgaaataat ctttatacca tatttttggc acattttggc ataatatggc

206761
acataatcct gacatggcat attttggggt gccatattct gctaccctcc aaattgtctc

206821
tacccttcta ttatcttagc agataatagt acaacctccc aaattttggt ttccttctgt

206881
gaggaaaaca cagtttgtgc tgtgaccagt attgtagctc ctggggaaac ctgtgtggtc

206941
tcctctctct tctccctgct actgtaatac taacaaaaag aatgtttaaa ccataaattg

207001
aatcttaaag caatcaagta caaatcagag ttaggaaaag ttttaatcag caggtagaaa

207061
aaggatctag tgtgctttta tttttaaatt tttcattaat ccactaaagc ccagcttgtt

207121
atttttacct tgtttcatct aaaattaccc taagatgctg gcatgacctc tagggtgtga

207181
ctaaaatgtg tttgagtctt tatttgacat ttaagccagc catgaaaatt agcattggtt

207241
tagagctcca gggagcaaag aagtcatcct gagtctgaag aatttctgtg gctgtaactt

207301
ggaatttcat acaaatttga cctgtccaag acttgcttta attattcact aacaccagca

207361
tctggcttta acacatcttc atgagtatca tcagaactag agaaaaaaaa ttcccttaag

207421
aaatttttgt acataggtca ctctcatgtt tgttgctaat aaaaatttta gaggtcttag

207481
taatctaaaa aatatatatt ttacctgtaa agtggtacta tccaaaagga actataccaa

207541
aatacgtcag acataaaagt taagaggtta tgaaaatgta catgcaattc tctttttgct

207601
tgttcttagt ttatttactg cttgttttca gatagtcagg tagttactct ttagagatgt

207661
aaaataaagt atggacatga aaagtagtta tttaccaaag gcaattatca agtatcaaaa

207721
catgcagagt acttactgcc agttcaggga gacaacaaaa caattatata taatatagta

207781
gctttttagc ccaatcttcc aataattgct aggccaacat gctaaattta agagttcttt

207841
acctcttaaa tttagtagtc tcagtaaata aaatttgttt agttctgcag gggcagaaag

207901
atgtgatact ttgtccctat cataaggtca aggacaacac ttctctaatg aaagagggtt

207961
cacaagagaa aaacataaca catttcttta accaaagttt tatatgacat ggaagccttc

208021
agaatgaaga tttgaagacc caaggaaaaa ctgtccattt ttatgcttag attcaataaa

208081
gtgtgaacag ccatgtagaa gtgttattag acaaacaggg aattatctaa tagtaatgaa

208141
ctgagtgggg aaacccagca atacctgtcc agattcttct tggcctcact gttgtaacat

208201
ctcttcaccc tcctggctta tttggtatag ttccttttag acagtactac ttcatagata

208261
aaatatatat attttgatta caaagactac aatttttgtc agcaacaaac atgagagtgt

208321
ttcttcctcc cttgacctac tgttgaccaa gactaggtca tagaatttct ttatggccac

208381
cttctagaca gaaaggtaga gaaggttaga gtaataattc ttgtttttat ggccggcttt

208441
ggggaaaagg gggttttagt ttctacggcc tgccctgggg aaggggaatt ctgaattcta

208501
tggcbggttt tggggaagaa caaggggtga gaggtaggag agcaggagaa ggtcagagag

208561
accttggctc tgatgctgct actgaggcct tccagtgtcc tttagttcaa ggtgctcggc

208621
atgccaaagc agcacattca ggatatcatt ttctgagccc aacagttcca tattctgccc

208681
ccaacttgtt gcacattgga attgttcatg gacttacaaa aatattgatg ccatatccca

208741
gccctagaga ttgtgactta atttagctgt ccccaacctt tctgatacca gggaccagtg

208801
tcatggatga caatttttcc atatactggg gcbgggtgag gagatggttt caggatgatt

208861
caagtgcatt acatttattc tgcacattgt aatatataat gaaataatta tacaactcac

208921
cataatgtgg aatcagtggg agccctgagc ttgttttcct gcaactatac gatcccatct

208981
gggggtgatg ggacacagtg acagatcatc aggaattaga ttctcataag gagttcacaa

209041
cctagatctc tcgcatgtgc agttcacaat agggtttgca cccctatgaa aatctaatgt

209101
gactgctgat ctgacagcag gaggagctca ggtggtaata tgagttagca atgggtagtg

209161
gctgtaaata cagatgaagc ttcactcact cgcccaccac ttgcctgctg tgtggcctgg

209221
ttcctgacaa tcatctggtc ttctcactgg tattcatttg ttcaattagc atttgttgaa

209281
attcacatct atgccaggtg ctaaacccat atctgtgcca gtggccacga cctgacagtc

209341
atctggtctt ctcactgatg tccattcatt caattagcat atgttgaaat tcacatctat

209401
gccaggtgct atattaagta ctgggaaatt agtacaaaaa atatagacct tggagattcc

209461
agtgcaatgg taaaaatgga ctagaaagca acacactggg ataactactg cagaaaggtc

209521
agaggttaag tcacactacc tagggggtgg aggagattgt tggaaagaaa gaaaggatca

209581
ggaaaggttt tgtggagaag ctgtagtgtt ggcctaactc tagaactgaa gataaagaaa

209641
aggaagaaaa taggtgtagg agaagagaaa gggtatctta gagaaatgaa acagcatatg

209701
taaaagcctg gatgcattag aaatcaactt gcagccagcc tctcatctta tgttttctct

209761
aacttatctt gtatatcatt gttgaaacat ttttctcaca gcactgtatt acacccatca

209821
atttcctgct caaaaatact ctggatcctt actaataaca gaatgaattc tgcactgcag

209881
acgtgacatt agggcatgcc agatcctcct ctaaagcatt taaactgtcc tcttcattgt

209941
ctatctgaag accccaggta tgttttcatc tcttcatttt tgcttatatc attcccctgc

210001
accagaatgt ccctcctact cctttgacca tgtaactgaa tcctcccttt gttcagggtt

210061
ccttgatacc actccatctc tcatctcaat cttttagcat ttatgtttac ttttactatt

210121
cttgtttgtt ggtaattaga tggtgcccta aatatttatc tatatcttta ctttttaatg

210181
aaattgtaaa ttccttacag aaaagcatag gaccacattc ctttatctct ctttctgcat

210241
atggtacaat gccttaaaat aaacaaaatt tatttttatt actgataaca aaactgaatg

210301
acaataatat aatgagtttg gaaaatggag aaaccaagca tttgcataat tgcctagtct

210361
ttgatcattg atgcacacta cttttacata attataatga gagtatacaa attgttctgt

210421
attctgaaat tttacttgac attgtatcat caacatttgc tatgaaaaat aataaatatc

210481
agcbgggcaa ggtggctgac acctataatc ccagcacttt gagaggccaa ggtgggcgga

210541
tcacttgagg tcaggagttc gaaaacagcc tggccaaaag ggtgaaaccc tgtttctact

210601
aaaaatacac aaaaactagc tgggtgtagt ggcacaagcc tgtagtctta gctacttggg

210661
aggctgagac atgagaatct cttgaaccca ggaggcagag gttgatttga gccaagattg

210721
caccactgca ctccagcctg ggcagacaga gtgagtctct gtctcaaaaa aaaaaaaaaa

210781
aagataaata tctttggata ataactaaaa gcatcattta cctggtgtgc caggtactgc

210841
tttgcttaca ctgtttcaac ttttgtatgt atgtccttat tccaattcca tgaggtaaca

210901
ctggtgttat cctggggaaa ctgggagcac tgagctcaaa aagagtagag ctgtgctact

210961
tactaggtga ccttggatac ttattttact tagcgaatcc tcagtttcct tatctctgag

211021
atggggataa taatggttcc cacctttcaa gattttgagg ggatgaagtg agatgatgga

211081
cacgaatagt gcctggcaga tggccaacac tcagtgtgct ttagctcttg ctgccgtcac

211141
tgttgcbggt cccattttac aagtcaggaa actggatcaa aggcatttaa taactctccc

211201
caaatcacac acctggtgtg tgacagagcc aggattcaaa cccctgtccc aattatgaca

211261
tgagataggg atcacagaat ttaatacgat gttgtccaag tgtaacattt tacaatttag

211321
tgctacagag aacatgtgca gagttttgag agaaaacaca gttggatatc tacagattat

211381
cttctgcttg gagagaaaga gaaattgaga gagatagaga gagagagatt cccaggggcc

211441
cgagctctct acagcagcac agcatggctg ggtcagggct caggatagaa ttcctgactg

211501
cctcctccca ggcggtgtca taactggggc ttctgaagcc caacacctgg gccctctcct

211561
tgggtctcaa atggagggtt gaatcctctc atgctcactt actaacaaga acaattccca

211621
ctttcaatgg ggtaacagtc tgaggggaaa tgggctaggg ttttgcctgg aagtacctag

211681
ttatttctta actttgtagt ttggagattc agcataaaaa ctgaagtcag ccctgttagt

211741
agtattgctg cttatacagc cgtccaccct tatcagaggg gaataccttc caaggctccc

211801
cgtggattcc taaaaccaag gatactactg aacctgattg ctgtcaatca gaacatattc

211861
ctgtttatgt cttccaccac acatttaatg ccttttctat cttaactaac cacttatcac

211921
acactgtggc cataactttt gcagtttgaa gtacaacaga aaaactagca agaatttctt

211981
ttcccttctt cacaatttca ggaagagaag acgtcttacc atagatctta gcaacctcag

212041
catacttttt tttttctgcc ctcattaggt tgagaacttt cccttattca cttaaaggag

212101
gcactttgtg gcttctcttt ggcatatcca aattgccagc atcactaaac ttatgctttg

212161
ggggcattat taagtagaat aagggttact ggaacataag cattgtgata ctgtgacagt

212221
caatctgaga acccagaggg ctactaacag gaggagagtg cagactgtgt ggatttgctg

212281
aacaaaggga agattcactt cccaggctgg acagcacagg atggcatgag atttcatcat

212341
gctactcagg acagcacaca atttaaaact tatgaattgt ttatttctgg aattttccat

212401
taaatatttt tggactgcag ttgactactt gtaacaaact gtggaaggca aaactgcaga

212461
taagggggaa ctactgtaat agttactgct tatactgctc ttgctatttg ccatggacta

212521
agctaaacac attacataca ttattttcta taatggatgt gacaatccta cagagtagct

212581
actattatct ccattttaca gatgaagcaa ctgggcatct taaccattcc agctactgcc

212641
atcagcattt gccttaggaa aaaaatgtgt tttgaataat cacttccagt atttgggatg

212701
attttcaata attctaccag cctaactatg aagttatatt atctaggagg cctctagttc

212761
ttatttttaa tctttgtacc ttcgagtagc ttcttacctc tgtaactcac tcccacagta

212821
atatttcatg agaagccaga ttctctggac tattggttaa attcttttag atggcagtgt

212881
ttgttatgaa aagacttttc attcttctgg tcccttcact ggaaacagct agaaagtaca

212941
agttttgatt acagttgcct aaacaccagt tttgaaatgt ctttcatttg cttgagcaat

213001
aaatttgttg ctcaatcata ctatcaaatt gaaaacaaga ggaaaggaaa gtcaacctaa

213061
cctaacccaa aaggggaaca tgtttcctgg gatgagaatg tgtcaaaggc agcatagcat

213121
gacctaacac ttctgtgtaa tcgtggttgt atcatgtgtt atgggtaaat tatctattct

213181
gtaagttagt ccagtgtgtg cttcttcaac taactgtgaa agcattcttg aaagaccatg

213241
aaaccttatt attctaatta ccaacacaac ggattgataa atgaatgatg aggccaggta

213301
ttattgtcat taaatagacc tcgctcaatt atttatcaat gagtctgggg ttacagctca

213361
gagagctgtg catattgtag cacggtttgc ttcagctctg agacctgaag accagattac

213421
agtcttggca ggtggctttt gttgaatgca attcaagggg gtggtacaca tttgtttcag

213481
tcagacattt ggatggtttg aggccaacag atattcaaag tttatccaca aaagcctatt

213541
tcattttaac catgtagaaa aatctcttta atttattcag ataaatacaa atgagtagga

213601
gaatggatta gctgtagaaa atcatacatg taaagatgtt ttcttgcatc ttagtgttct

213661
aaagactgtt ctttattttc ttagattctg ctatctgtca tggacacttc actgttctgt

213721
attgatcaat gtttatcttc atatgagatt tgtttttgta tcttctttct aattgtacaa

213781
tgaaatatgt tttctggtta agaaatacgt tatcaaggag gatagaattg ggtgatacta

213841
gtttttttcc atcctgaaat catgccagct cattgcaaag gtcagccctc aaaatagtat

213901
taaggcatgc cctctccttg agtctctgat accttgcagc ccaatgtccc ttcttgaagg

213961
cctgtcacct gcaagagtac tttcttacat cctatgagca tcagatatgg gggaatgaag

214021
aatctcttct tgctaaacaa atattcttgg tccaccttct gccccctggc tttattttaa

214081
acccatcccc aacatatctg atgagttgag tctagtaatt ctgtcttcag tgggctatgg

214141
ggagcaggga ttagctaaaa tggcbgttca gggacctctt tggtataaaa cttggtgggg

214201
gtgctggcag ggatctctca gagaatgaag gaggggatag agcattagag aagaaaagaa

214261
attcatacct gagattatgt aatagataat agagtctgga ctttgtttaa aaaccagaat

214321
ctaagatata tatgttgagg ctagggcggg gtagtaattg aaagagaaat atgaaactat

214381
acctagcgtc aaggaaaact aacagtaatt gaagagacaa aaataaaact tgtttatatt

214441
gttcaaagga aaatgatatt tataacatct gacaaaaact ttattaatgc catgtagaca

214501
gggttttata ttattaactg agtttataat taattttgta ctgattttaa tttgactgtt

214561
accttggctt ccttctctgt ttcttaagtt ttgctagttt aatgttcacg agctcacaaa

214621
attaaaaatc ttggtagaaa tatggagtag ctatttcttt acatcctttt tagaacaaag

214681
ttgtgctttc gaattgacca cttatctaga aagtgatata aatctaataa gcaaaactgg

214741
atgtctttta aattatctgt taaataacta gagcagtgga gatgtcctga aagtgagcac

214801
tttattacat atgaaaaaca aattttaatt ttactactaa gaagaatttc catttctcta

214861
tttatatgtg ttcattattc tagagattaa tatgataact cctatgtata cttagttttg

214921
tgaatttcaa aattcttgat gccaaataac tgaagtatag taaattctgc cgtaacatga

214981
tgtatgggtt cctaaaaatc ccgacactat gcaaaattgg gcaataaaaa cacattttac

215041
taaaaaaatg gggataggca cacaatacct agaaatatca ctagtggcac attacaaaaa

215101
atatgggaat ttagtaacaa tgacagcaat attttacaca tgttaatggt taagaaattt

215161
acaataaata tggcagttta ctttgaaaaa gacctaacgt tccctgtgga agttggcctt

215221
caaaagggtg cagcttgtga gtttttgaga agtgttggga ggagagtcgt tgttgtccca

215281
gttgtgagca ggtggggctt ttctacctgt gtggggaagt gtggtagctg atggatatgg

215341
tatgtggatt ttgtgtattc ctacgctgct tggtttagct gggtgcagtt ttctgcattt

215401
acctggcgtt tcttgtggat agaatcacat ataagcaaat cccagacttg tgttgtgatc

215461
aaattgttcc gtaatatatc aatcatgtta gaacaaggtc acggtttcaa aaccggcatt

215521
gccgtagaat tgactgtgta ataatccctt caacacgttc acatctatga tcccaccttg

215581
ttcttgccac catcttagca agcaggggtg cgattgcctg accatttgtt tgttttctgg

215641
gaaatcttga cctattaaaa gccacacagt tactgaggaa acctgtgtca gaccttgcct

215701
aggtctgtgt gagtctgagt caggtttgct ttcctctgaa aaatcagaca ctcatgtatg

215761
tgggacaaag agcatcagaa acatgggcaa ggtcatagag acagatccca gagactggat

215821
tagaacccaa cttgcttgat tttctgctta gaggcttcag ttcaccattt tagaaagtgc

215881
ctgctggctg ccaccctccc tcctgtctta tcacctctaa aagacattgt taatgcttag

215941
acaggatgtg ttttcttcat tgcatggatc taaaaaccca gccatgagaa cttagttttt

216001
aatttttgcc attgctttat tggatatttt agaatgtgca aaaggtttta gaaattgttt

216061
ttcaactaat tttaccagca cagaggtcat gtcaaatgtc agggtgtttg acaacaaggc

216121
caatctagtc tatcaattga gtttcagaga agattaatga taaagggtgc aatcccaaag

216181
tctgggaatg actttgcttt caagcattaa ttattgtgga aaataaaatt attagatact

216241
cccttgtcta catctacccc aaactatgtc aatcagctct atttctagaa ggtttacatt

216301
tattaaacac tccctgtggt caatgcaatg gtcaatgcta tggaagttac aacaagacaa

216361
gatattgtgt ccgctatcag gaaactgatt tgggagttct gtttgatgac cgaagagagt

216421
ctttaccact gtgcctatat ttttatgcca gaatatgggt gggtgcacat gtacaggtga

216481
gtaatgaggc cccactccct agtattagtt aagttagcag gtgtgtgctg tttttttggt

216541
cactgtgtat tgcaaaattc tgagtttggc actgatacta aggaacatct tacagaaaaa

216601
attccccact gacccttctt ttttttttct ttttgaaaca gaatctcact ctgttgcccc

216661
aggctagaat gcagtggcac aatcacagct cactgcaacc tccgcctccc aggttcaagt

216721
gatcctcctg cctcagcttc cccagtagct gggactacag gtacacacca ccacgcctgg

216781
tcgatttttg tatttttagt agaggcaggg tttcaccatg ttggccaggg tggtctcgaa

216841
ctcctgacct caagtgatcc acccaccttg gcttcccaaa gtgctgggat tacaggtatg

216901
agccactgtg cctagccaga cccttcattt ttaaaagttg actttatatg ttaataggag

216961
tttaattata gtcatatgtt gaagggtctt ttctgtaaaa ccacatattc caggagccat

217021
ccaactgagg acagcattgc acttgtggaa ccacaatcca ggcttgggtt atctgtttct

217081
atcatgacag aggctactcc atcacttaaa ctatatgttc tgcagccccc gagagctgaa

217141
gacaagcctg gattgcctct atttgtaatt ttcttttttg taaatttttt tttggtaaat

217201
tgtttttcaa acaaacaaca aaaatgactg tcccagtcag ttcaagctga tagaacaaat

217261
ggccatagac cgggtggctt aaacaacagc catttatttc tcacagtgct agaggctgaa

217321
agtctaaaat cgaagtgcca gcatggtcgg gctctggcaa gggccttctc ccaggttgca

217381
gatggctggc tccttgtgtc ttcatgtagt ggaagcaggg ctagctagct ctctggccac

217441
tacttacaag ggcactaatt ccattcatga gggttctacc cccatggcca attacctcct

217501
aaatacccca cctccaaata ccatcatgtt ggagattaga tttcaacata cagattttga

217561
tagggacaaa aacattcagt ctataacaat gatcaaataa ggttacaaaa attatagtgt

217621
atgtagcatg cttgcattat gttttgatga attaatgttt tttattatgc ataccaaaga

217681
aactaatgca actgctgtaa atgtataaat atttgggagt aatgttaaag tttacattta

217741
aagccctttc taaatgtgag gccgaaagta ttccttttct ctctctttct cttctcaacc

217801
ccatttactt tacagaatga tttttctgtt ttaagtcata attgcttttt ttttacagga

217861
ttaagtacca ggtcattaag tgtgttctat gtcagtttga cctaacctct ctgccctttt

217921
cttttttcta aaggaattct ttaaaaagaa gaagaggaag tattttaaaa taaacatttg

217981
actgccagaa tgtgatgtaa acttcaggtt caattctaca cttgatagaa atgaaaagaa

218041
ctagtgttct ctattttgac atttagcatc aattcccttt cagtgattcc agctgattag

218101
taagtgagac taaaatatct tactcttcct ggtcagcatt taaaaattta aacatggatt

218161
gaaaatttct aggttatgaa atacagtcta ggttcacctg tgaaggatct agaagaaata

218221
agactgcaga cctggtaaat tcaaatgtcc actacttctg tattctagtc attgcaactc

218281
acctcctttt atcccttatg ttatttttat tttctcaggg aggcaaaaaa atttgtgagt

218341
gaaaatgaag gggctcttgg gaaaggaaaa ggaaaacggt ggtttgcatt taagatgatg

218401
atggccaagg taggtatttt tatagttgtc tggtttatgg catattgcct ctaagaagaa

218461
cactggttct tttctaaagg ggtgaaaaaa atcttacatt ttgtatatat aaaacacaaa

218521
tactcataca gtatatacac agtatatctg tggtattgaa atttacaggg gagatttaaa

218581
aaattgttct tagaagagtt aaaatgaaaa ataagtcaag aaatacagat ttatggcaaa

218641
agacttactt gtgtgacttt agcacttcca aatataaaag attgcatcct ttttcatttt

218701
cattctctgg aagtgaaggg gttctggtca agttgttttt ctcaaagtat ctgtatagtt

218761
tttttctacc aggaacatca actatacatt ggacagaaaa taagaaaaca ataaatgata

218821
tactgataca aatatagatt ttggggaaag acagaaaagc aactaacatt tatttaacac

218881
ttactatgtg ccaagcactg aattgaattc ttttataaag ttatatttaa ttcttacagt

218941
aaagtaggaa catagatatt attatctcct ctttacaaat gttataccaa ctgtaagcta

219001
aatgtattcc cataaagttt tgtgaataaa gttcatatat cctaactttc atatatatat

219061
atactcacat acaatagatt aattttgtct gtttctacag tttaaataaa ttgaatcata

219121
tagtatctat gcatttgttt ctggcttctt tgatgcaatg ttatgttcac aagatatatc

219181
cacgttgttg tgggagttat acttcatttt tattcatgtg ttgtagtcta ttgtataaag

219241
atgctgtgac aatgtattta cccattctat tgtagatgga catttgggct gtttctagtt

219301
atgagtaatc tttttttttt ttgttcattt ttaaaattaa ctcatacaca attacttgtc

219361
ttctggtttg ttgaaacaat aatgcagaca tttgctacaa caatgactgt taaaatggct

219421
ggccacaaaa tctccagcaa tacattaatc tgaagggcat tcttgatgaa gttgactaat

219481
tttgccattt tcatccacct tatagtattt caggacagcc agcttaacct tccttttctt

219541
atgcttattc ttctttggag tggtgtaaga cttcttcctt ttcttagcac caccatgaag

219601
tctcaacaca agatgaagag tagactcctt ttgaatgttg tacccagaca aagcacatcc

219661
atcttccagt ttcttgccaa caaagatcag tctttgctga tcagtagaaa ttcctgtctt

219721
atcctagatc ttggacttcg cattttctat tgtatccaag ggttcaaact ccagagtgat

219781
ggtctttccc ataagggttt ttaaagaaaa tctgtgtttt ggtggtggtt ccactgcaga

219841
aggcagatgg gaaaaaaagc gtgggtgatc ttttgaactt cagacttgtc tcatgctatt

219901
atttagacaa tagtgcctgt ccagctccca cttcatccca gcatttgcat acatgcaaaa

219961
ttctctgcca cattctcatt cttcctggtg gtcctcttga ctatggatga cccaacattg

220021
gagttaaata gaaagaaggc cttttgcaaa atgattttat gacttgttgt cttctctttc

220081
aattaagctg accaatctgc ctctaccaga atgcagtgtc tcatgtcata caacttacca

220141
tcttgtattg aactcaccta tttgtacaca gactatcctg gtagatcaga aggctttcaa

220201
gacaggacct ggaaataaaa gacagaaaat aaaatttatt ttgtttatta tttttattat

220261
ttattttatt taattattca tattgagtcc ttcatacaat gaaaactaat taaacacata

220321
ctctgttcca atcaccctat tatgtgctaa tcccctgctt tcttattgtg ttatataata

220381
aatagcbgtt tctgagaggc cagcatattt tccataaaac aggggatcga taaacatttt

220441
tttgttgaat taaattggtc tggggttagt ggagaacagg gaaacaagtg aaacctactg

220501
tttccccctt tgactagaaa gtagtatttg ctgccagaga gacatttcca agcttactgc

220561
attgtaatgt tttgaggtgg gggataaaca tcttgacaaa tcaagaggtt ggactttact

220621
tttgtatttg actttctttt cagaaatggg caaaattcct ccgtgatttt gagaacttca

220681
aagctgcgtg tgtcccatgg gaaaataaaa tcaaggctat tgaaagtaag tccttatcag

220741
atctcaggtg gagaaggttg tcttagagaa gtatctcata agcttatcag atgcctttgt

220801
cagtttctgg acttttggga agactagaaa caaacaaaca aacaaacaaa aaccaaatca

220861
acaaaaactt tgtttatgcc tgctttcgtc actgtgaaga tttgctagca cttaccaagg

220921
acaatactgg ggaccccact ctcgtgttct accttagtcc aaaacattac cattctaacc

220981
tggttttctc tcctatacag ggaagtcact attgtgcaca atgacattga atcatcttac

221041
ttggaaggca gagattttat tttggcaatg aacatgacat tgagaatata tactctcatg

221101
aatgttagac agtaatcaaa atgaacaatg ttttaacaag tgaagaagtc ttagtctggg

221161
cgcagtggtt cacgcctgta atcccagcac tttgggaggt tgaggtgtgc agatcacttg

221221
aggtcaggag ttcgagacca gcctggccag cgtggtgaat ccccgtctct actaaaagta

221281
caaaaggccg ggcgcggtgg ctcacgcctg taatcccagc actttgggag gccgaggcgg

221341
gcggatcacg aggtcaggag atcgagacca tcccggctaa aacggtgaaa ccccgtctct

221401
actaaaaata caaaaaatta gccgggcgta gtggcgggcg cctgtagtcc cagctacttg

221461
ggaggctgag gcaggagaat ggcgtgaacc caggaggcgg agcttgcagt gagccgagat

221521
cccgccactg cactccagcc tgggcgacag agcgagactc cgtctcacaa aaaaaaaaaa

221581
ataaaaaaaa taaaaaataa aaataaaagt acaaaaaatt agccaggcct ggtgcaaaag

221641
cctgtagtcc cagctactca ggaagctgaa gcaagagaat cacttgaacc cgagaggcgg

221701
aggttgcagt gagccgagat cacactactg cactccaacc tgggtgacac agccagactc

221761
tgtttcaaaa aaaaaaaaaa agaaagaaag aaagaaaaaa aacgaagtct taaaacctca

221821
ttttcaaatc tctgaagtag aataagcaat agtcatccag gagcttgcta tctgaatatt

221881
cacattgtgc ctttattttg tagaatattc ataggaagga aggaaggaag gaaggaagga

221941
gaatatagcc aatcaaaaac ctatttagtt tagtgcttta ggcttagaat aaggcaagta

222001
aacattttaa aatattgtaa ataaaaatag taaattgttt tttaaaataa taatctaaaa

222061
aaagggataa catttgaaac aattttgagc acaatctttc catattctgg tttctaacgg

222121
tttcaactag gatctgattt ccatccattc ctctctagat tggaggcagg ttttcctgct

222181
ggttaagtgt ggcgttgtat aattaaaatg gaggctccat agggagataa cacagctgat

222241
ggatagcttg ctgacatgat tgggcatgtt ttaggagtgg ctaaccctcg gttccctgtc

222301
tctcaatatc agatgggaat tattaagtgg caatgaatta aaatacatca gctcattaat

222361
tgtatcccct tccacacatt cccagtgcca tttctctctt gctttaattt cctccttaac

222421
acttaccgct atctaaaatg ctatatcttt aatttaattt tttgatgtaa tcttaattca

222481
ttttatgttc atttctccca atagatggga aatttagttt tgttcactcc tgcattccac

222541
ttggcactta ataaatatgt attgaataaa attacagaca aactcgctaa atgtctacca

222601
atctaggaaa aaaagaaagg aatttagata catcaaaaaa gagaagacat catggatttc

222661
ttaggtttca actgtacagc tcaaatgtgg taggttgaga ggcactgaaa aacaaaaggc

222721
catttggagc attacggtcc tgatacaata tatatagtaa gaactctgaa tttggtcttt

222781
gctttgctgc agattagctg tttgacttct agccagtcat ttaactcctc tggacctcag

222841
tctactaatt tataaaattg tagggctgag tcttgatcag ttgttagata aatcccaaga

222901
aatttgtaat taatgatagg taaatatata catttgaaaa ttatttttaa agcacactag

222961
agcaggttcc agcctatcct aatagtaata tcatgctcat ttgtgttcca ataggctata

223021
gccagtgaaa caaaaacaga cagaattatt tttattgcca gaaattgcat gcagcaagag

223081
ttacacatat gaccaccatc catcatgagt gtcacagtag aaaagacaga ttgagagcta

223141
tccaataata accttcagtt atctcctctc ttcttctctt cttctagtaa atttggaaag

223201
ccacgctgga aaattgaggc aaatgtagat tatttttctt tccatatata atttatgatt

223261
tgattagttt gtcatgactt cttcactgtt aatggtgctt tgtctcaact gtgaagaact

223321
gagctttatt ttttatttta tcaatattca ccacaccacc atttattgag taccaccatg

223381
agtcagatgc tctacaaaca ttgtttcatt taatcttcag tgttcctgca atgtgcacat

223441
taaccttcct attttatagt tgtgattaaa taactgtccc agaattagta gcagagctga

223501
aatataaggc aaaatctgtc tgggttcaaa acgtatgctt ttccatgtgt taggctgctt

223561
tctcctttag ggaaggtttt acatactttt tctttttaaa tatgttttgc accagttcat

223621
aaaaagtatt ctacgaggcc gatggcagga tgagtagtta tagattttct tgatcgttat

223681
caaggaatta tttttcattt tctcatgtat ttacttttta gtgagtgatt tatttaatta

223741
tatgttttgt attctatagg atgcttaatg tactgatttt aatgataacc atgaggcttt

223801
gggctatagt attagttgaa aaaatatgaa acctatgtaa gaatatatta ttagagcact

223861
ggattggact atcttataaa aagtacccta ctaaatatag gtaaagcatg tatctgtgat

223921
cacctttgaa actgaactta atgcaaaatg ggaagaaata ggacatgcaa tggattttct

223981
gagttgagga ctttttgacc cctaccacct ctgtagtttg gacaatctgt tgaaatctct

224041
ggttctgttt ccacatttgg ggctactaca atatctacaa catcttgggt ttaactagtc

224101
actatacaag atcatttcca gctcaacatt ctatgatgtg taagttacag tcagttttac

224161
atgtatatgt aggcatgtga aattcattaa tcatactttt gattgataaa tcctcaaaaa

224221
tttgaatgca aaacagattt atactaagag gggactatat aattgccttc tcaaattctt

224281
tttgaaataa agttggttaa gtgtgtaccc tacttataga atacatattt aattataaaa

224341
cggatataaa tgcttttctc ttaaataaat ggccatttaa tcttacaaaa ggttcagaag

224401
tatcattgta ttccatttcg acatcagaat catctaatat atatcttatt taatcctcag

224461
aataagcctg acattattga ttaactgagc aaatagtgga tgcctaacat gtttctaggc

224521
actattgcta ctgccaaaga cagcagagac tctaccctca ttgatcttac atccaaatgt

224581
gttaatgtat gtatgcttgg atggggaaga cagaatataa tataagcaaa taaataatga

224641
cggtaattgt ggattgtagt aagtggcatg gtcaaaagag gagcbgttgc cttccattcc

224701
caacagcctt tctaatccac ttttccccac tctctgctca gtatctagat aataccaaat

224761
aagtattttt aaaatgtggc taaaggagtc caaaattaac agcctttact gagttttccc

224821
aaagctctgt ccaataattt gcagaatcaa gagcgggacc caaattagag tctaaaattc

224881
atactgtttc catcttgatt ccagtaagac ctagatctct ttattagtgt gaagcggatt

224941
ctcacctgat gactcccaac tctgtttcac ttaaaaaata gatttgataa ttcctgccac

225001
agaggatact gtgacgttat gcatcacttg ggaatactgt ggggttttac tgtcacgtca

225061
gccttaaggg gatcatgcct aaaactcgat ggttgctcct gtggacacat cttattcatc

225121
tcattgaact gtgtattttt ctgaagcaac tgcatgtttg tacccccagg aaatataatc

225181
tatacccatt gtgatgccaa cattattatt aagaccataa attaaataat tgaatgtatt

225241
tctagcbggg gattacaaat ttttctcagg atcaaaatct actttttcct aatagtagat

225301
tgcatcatca aaattatagt ttcagaaacc tatttttttt cagacaggaa atagctttgg

225361
ataggcaagc caaagcacag ggcttaaacc ttatgtttcc ttgctgccct aaggattcta

225421
gaaaatacaa atcaaatttg tcacatttaa ttccctaccc ctaaatagtt cgaaaaaatt

225481
gtgcttcaca ttctagccta acatgatggt atttatattg tagtcacaca gcaggtcatt

225541
taattggtct tttcccattt agaaatactc atatttatct gcttgtctta ttacccatct

225601
attcaagagg aaatgatgtg ttatgacaga ctacaaatta ctttgcctta ataataaaca

225661
accagaaaga gagttgaaat tttaacttta atttgaaaga aacaagaata ttcaggaaca

225721
agaatatgct taagcataaa gcctcagttt aatacgtatc agagactctg ttttttggtt

225781
gttgttgttg tttgtttgtt tgtttgtttt ttgagacaga gtcttgctct gttgcccagg

225841
ctggagtgca gtggcgcaat ctcggctcac tgcaaacctc tgcctcctgg gttcaagtga

225901
ttctcctgac tcagcctcct gagtaggtgg gattacaggc tcctgccact atgcccagct

225961
aatttttgta tttttagtag agacggggtt tcaacatgtt gaccaggcag gtcttgaact

226021
cctgacctcg tgatccacct ggctcagcct cccaaagtgc tgggattaca ggagtgagcc

226081
accgtgcctg gctgagactc tgtttttata cattaataat ttactatgga agcagcattt

226141
atcagtctga ttaaagaaat aagaattggt cattatgggc atcaaatttg tgaatctgac

226201
tggctttagc tgattgatgg atattatcta tacctattgt ttcagaaaca catattcatt

226261
gcatgtttat tgtatatatc atagtcttaa gaaaattaat tgaactatgt tttacttaaa

226321
gggccatata gcagtgtggt taagagagat ctagatttgg agtcaaacac ctgtagctca

226381
agactgcctg gtttagaagc ctggcttcct tgtttactag ctatgtagcc tatagatcta

226441
agtctctgta aaatgggaaa acaatagttc ccatttcgta gggatttgat gatcattaaa

226501
taagttaata catatagatc aaattggtgt ttgaaacagt gattcactaa atgttaccta

226561
ttattaatca acttttgatt cagtcaacaa ctgtgttaaa gtttttgttt cctgattcat

226621
agtgggacta ataatactta acctcattaa gttctagtgg cagcataatg agttgatgct

226681
gataaagttc ttggaacaca taactgacca tcaagatata ctagctatta ttattattat

226741
tactcatttt gcttccttac actgagagat taagtatgtt aaaattgcta ttcttttcat

226801
ttatgctctt ttagtcacac taatcaggca tttcttttta gtgaacatca gttttagtta

226861
acaacatccg gtaggataga accactagat aaaagggata aagagggaag atttcttctt

226921
ttttgttttt gtgttgagac aggaaaaact ggagttttat gacaacttgt tgtttcattt

226981
tctctacttt aagatcttca tttgttttgt tactgtgttt tctcctctgc tattgatagg

227041
tctagtgtgg aagaaacttt gtcttctgga tttcttagtc tcttccacct gtgtctgggt

227101
ctttcctata atcgttctag ttttaatgaa atctattggc ctgcaattca ttttctttac

227161
acttaagatt ctgtaaagac tcaacctcca aataaaatag ttgtgaagcc actctcaaat

227221
ctgagaactg gagtttggaa gttttggact ctaaagtata tttcattatg atgcttaagc

227281
atgttggagg aggggatact ttctgaaaca tcttaattca cttctgtctt ttgcatttaa

227341
gtatatttgt accctacacg caagaaattc atttgtcagg gattgtgtgt aggtgctgag

227401
aggatgggcc gtggcaataa ttagaaaaac aaaagcataa aaagtgagga aggaagaaag

227461
gaatggtggg ttagtatcct atatgcggga tttcatactg gaagatctta catgcgattc

227521
cagggaaaaa cttacattga tacctagtga ccaaggcttt cctccagtaa atgagtaact

227581
gtaatgagta acaaactgta agtccactgc cttcaataaa acatgatgag tgaacctggc

227641
tgagcagccc tcaggtagtc gttaccagag aatgtagata acggccatga aatggtatga

227701
agtcactggg agccaagtgg gtgatcagat gtcctaggag aagcagacca gtgcacctgg

227761
tgacagtgct gggctgggct gaggtagggt ggggtggggt tgtgtatcaa aaccacacac

227821
ccttagaaac cttatagaac tctgcacccc tcggcaatgt gaaatcaatc caaattctct

227881
tgtgagcata aagaaaaata ttgacttcaa aatcattgat tttttccaaa atatccattt

227941
aaagattgac ttcttaagtt tctaaaaaaa aacctgccac tgttttacag gaataagaaa

228001
gatggtaggt aaagaataga caaaggggcc aggtgcagtg gctcactcct gtaatcccag

228061
cactttggga ggctgaggcg ggtggatcac gaggtcagga gttgaagact agcctggcca

228121
acatggtgaa accctgtttc cactaaaatt acaaaaatta gccaggtgtg gtggtgggtg

228181
cctgtaatcc cagctactca ggaggctgag gcaggagaat tgcttgaaac tgtaaagcag

228241
aggttacagt gagccaagat tgcgccactg cactccaacc tgggtgacaa gggcaaaact

228301
ccatctcaaa acaaaacaaa aaaagaatag acaaaggtcc agaaatagag gtgttactgt

228361
cctgtgaggc cggcctcatc taagtaagta gaggctggaa tttgctaccc atgaaccttc

228421
cttttccatt gataatgctt ccccactgat aatgtttcaa agccagaagg ctccagaaaa

228481
tcattggtca atagagatgt ttagctgaat gttagctgaa tgggacagaa cacatgggct

228541
gatgcagcca gggactgaag gtgtttgttg ttttttcttg ggcaactgac aatgataatt

228601
tggaagattg ggaaagctag caacttggtg ctgaatctta aatgaccgtc aaagaaactt

228661
ttgcttttgt aaatctatga aatctgaacc taagacttaa cctcttcatt tttcttcttc

228721
cactctctgc tttaagaggg tgcttttttt ttctctctct cccaatgaga attaaccaat

228781
cactttactt ttcacttctg ggggcagggg tgagttgact gaacattctt gcctattgcc

228841
tattcattcc ccaaagctga agtggttttt taaaagtcat gctcatcacc ccttcctctg

228901
gccctaatgc ttaacacctg tcaatgactt ctccttacat tttaaataaa attctcactc

228961
tttaccatgg gttgagaggc cccacacact gtggtttggc ctctccatcc ttatctgtca

229021
ccactttccc tcattcatgt actccaactg cacaggcctg agttttattc ctcagtagtc

229081
ccaagccctt gccccttagg atctttgttc tggctttttc ctctgcttga gctgctcttc

229141
cccagctcag catgttgctg tcttttcttc aaacttcaga tctctgctta gatgacatct

229201
ctgatgttct ttccttgaca aaactttcta aagctacccc tttcaatact ttcccttccc

229261
tcctgtagga cctgctatta tctctatctc tatctcctgt catctacatc tatagctaat

229321
gtctatgtct gtatctctat ctctgtatct ttctatgtat cttacatatt tgttgtatcc

229381
atacctcact aaaatgtaag ttctattata gcagcacccg tatctatgac attgtgcttc

229441
acatctaaga taatttctgg cataagatgt gtggagtgaa tgaatgaatt tcagctttta

229501
taccatccct gtaaaattcc agtaatgggg gaaacagcac agaactgctt gtaagataac

229561
tatccgtaaa ggatgtggta aactcttttt gagaagaaca ttgtttgcct gagaaaagga

229621
agagaaaata gcagtaatta taattatagt gatagctaat tactagctag gcactgtagt

229681
tacctttaca tatatttgct cagttatcag tattaactca agaaataaaa tgcactctgc

229741
aggtggcaat catggctgct cagcaaaagg cagctttccc ttggatggac tatgatgggg

229801
taggtcacat gcagtctgca taactgcatt ctacgtacct tctacattcc acatgacagg

229861
gaatgcttcc atcatgatta acattttctc ttcctgaata gagagaaaag aatgctatag

229921
cctataaata taaaaaggac caatgcctca caattaatgg attcattttg aaggcaacca

229981
agacaaagct ctttttgttt gtttgtttgc tttgatctct cttcaaactt tttattttct

230041
ttgtaatagg tcagtttggc tcctcagtgg cctcatactt cctcttcttg agatggatgt

230101
atggagtcaa tatggttctc tttatcctga catttagcct catcatgttg ccagaggtga

230161
gatctgactt ccagtttaca aaacatgctg aaaaatgttt ctcctagaaa agtatttatc

230221
tcttctttaa agtagaataa ttaactggct attttcacgt cttagagtca taggatttgt

230281
aatgagatta accttcaaaa tggtgcccat gggccaaagc tcccaatcct tgcactaaag

230341
ggggtgtaag cctcttgaaa ttatataact tatgtataat ttcacatgta tgtttaaatg

230401
tgtattttta tgtggaaagt ttcatggctt ctttcagttt cccaaggggg tccctgttcc

230461
taaatgttaa aaactattgt tcaagaggaa gactttgaca ccttgtgagt tgtatttctt

230521
tattttgcca agttagcttt gaaagaaatg cttccttaat gcaactcaaa gcctccagat

230581
tttctatact gaagaaacac aaaatgaaca ttttccccct aagatacaaa gtaagataat

230641
gcccacaaca cacacacaca cacacacaca cacaaatagt gggatgggat gagagtggga

230701
tgggatgatg aggtccaaag tcagaaacta aaacacatag agggtccaaa tcaaagaaga

230761
caaagccctg agctaatgtg gggaaagggt cagctgaggc caaaaagcta gactgaggtc

230821
agagccttca ctcatatgaa gttaaatgat tctgacacct ttgaatgctt accttacaga

230881
agttggatta ggttttagtt aacctacaaa ggacctttta ggaccagtat ttcaaagcaa

230941
atttggtcca tacagcattg acagtggcca aaatttggtg gttttgggtg actttttatc

231001
ccgatagctt caaatcagtg ccagtttcta tactaagact cctattaaca taataataat

231061
aataatgctt tacattcata aagagatttg agcttttaat agtacaaagc actttcactt

231121
cttttactta ctgtgcgtca caacaaattt atgatgtaga ctgtagaaga cattttcttc

231181
acccatttaa aacatgtaaa tggagtcaca taatgctgat gtgacttagc taacatcttg

231241
gaatatattt ttttattaag ctgatctagg actagaaccc atgattcaat ccctttctct

231301
aagattttgc actttaatcc actagtttta taatccttga gataattcca gagcttctaa

231361
agttgtctgg ctcgtagaag acagtgacca aagatcagag gtcctgtgta gtttatttcc

231421
caagtgcaca ctttcaggta atgaagctga atgtgtgtat tttatctatt tcaaattaac

231481
cccagctttt tttttttttt ttttttttgc ttacctttct aaggaaatct gaaactcctc

231541
cattccatca ctggctacta tgacgttact tagtgtcaga tgcaggtata aatggagttt

231601
tatcagcagc atttattctt tcccccacac catgctgcct ccatgtggag aaaatgaaag

231661
gctgttgctg atttatttga ataatacgaa attacagaat gtctgctatg tagtggatgg

231721
agtgcctacg tgttaggttg gatgtattcc aagagctagg aagcattctg tctttggata

231781
cccttttata ggttgtatta ggtgctgagg ggcatcctgt tttctgggca atgattacca

231841
actccagcaa aagaacaaga gaatggacac cctgcatgct gactttgcag aaccaccaga

231901
ggccagggca gtcatctcct ggcagcaacg ctgtattttt cagctgcctc tacccgacgg

231961
gctcactcag tattcctcca aggcaaatgc ccttttgccc caaggtcctg tgtccctggg

232021
caagcctgag accttgatct cctttgtcct ctgtgccccc gaactttggg gcgagacagt

232081
gtgtctggaa cccaccttct attctgttcg gaccaggaag ccagatgggc caaaggccta

232141
ctttgggagg ttgtgcagct tgtgcacagg gagtgagcag agattgatgt ccagcccttg

232201
ttcagtcaag ctctgcaccc aggcttcaag ccatattcat cttctgttcc cagctttagg

232261
agggaagttt ccatctcaca gaagaagcaa catctgcttg gtaagctatg ggggctagaa

232321
aggtgctctt tccagttctc accaaggcac cttcctatga ccctattctt gccctctcac

232381
tggcccactc ttcccagtac tattctccct accgtttttc tcttccaatc tggtagcatg

232441
aatttgaggc agcagtcctg aattagtgat gaagcagaca ccataatcag ggtgcaagtg

232501
ttctcacgtt gcagacaccc acaaattaca tgattggatt tccttgagtt ctctctcttg

232561
acatgaagga cagaatctcc ctccaccctc actcctaagg ggtattctct tatgaaagtg

232621
tgggtaagat tgttttgttg agtcctatgt gactcaaaag gctacctctc tcctttccag

232681
acttccaagt cagaacagtt tggtggtggt ggtggcaatg gggtcctcag aaagccctct

232741
ggggaatgtg gttgacctga ctgcbggtgg tcccctgaac ttggaatgca gggtcctttg

232801
cactcccttt gttcttacct ctggatttag tagtcgattc ccagaaaatg ggaccccaca

232861
tggagaccca aagagtcccc ataaaaatgt ttcagaaggg cttttaaaca aaaccatttg

232921
tgatcacatg tgtggctcag actttgtttc taattgttca ctgctttctt tgcttcttca

232981
tacagtacct ctggggtttg ccatatggca gtttacctag gaaaaccgtt cccagagccg

233041
aagaggcatc ggcagcaaac tttggtgtgt tgtacgactt caatgtaagt gtctccacac

233101
aagtgtattg gtgggaggat ggatttttat ttagtttatt ttattctgaa acccacggcc

233161
tcctctcctg ggtcaggctg aatgtcttaa gaaagacgtc cctgctccct ttaagaaaga

233221
aaggaaagaa agaaagaaag agagagagag agagggaggg agggagggag ggagagagag

233281
agagagagag agagagaaag aaagaaagaa agagaaagaa agaaagaaag aaagaaacat

233341
gtccctttat ataaatgtga ctatgattta ggacaatggt aatatgatta tatgggaata

233401
tagactactg gataaaggtg agctcagagt tcaaagactt gaagcaaata ttcttatcac

233461
tgactttgga aaagaataaa ggaagagttt gcaaatgtgc tttttggaaa atcttgttgg

233521
attcctaggg aattaaaact tttacacttc ctattaacct ctttacttcc taaacaagcc

233581
tcctatttag tattactcaa tagttagtac taaataaagc taaatattga aaactaagaa

233641
atactaaatt ctaactttta aataatacta aaattagtat tattccattg tagtattcaa

233701
atgagcatta ctccttgagc tcccttaggt agagattatt actatggaaa ggagttattt

233761
ctgtccattg aaaaaccatt ttggactata tgattcaagt cttcgacaac aatgtaattc

233821
cacatattct ttttttaagt agtgactaga ctagaaatgt ctggaagcat atgcgtggga

233881
aagtagccag gttgaaattg aggaattgat aattcaagta atttttggag gctagacaat

233941
gagaataaaa ttttatacag attgcagaat gaaggaggga aaagcagact gcctgtttat

234001
agtgttaata tgtatatctc acaaacattt tgatttctac ttttaacctc cttaaattgt

234061
gagtttccca aagaagagat caggtctgct acatcttttc agcccgtaat ctagtcctca

234121
tccactacag gctaaatgaa tctcattgac tgaaaatcct gagtgagggg gatgattcat

234181
agagccttga agtaagaacc acaggaccag tttatgtgag gagtaccaga acatgcaaac

234241
cttaagaaaa gtttcccatc tccgaatgaa caaagcaagc tattgagtta gcatgaggca

234301
caatgatagc aacaaatatg tggcatttgt aatcttcaat cacccctgtc agttggactt

234361
tccatttcaa ttcagcattt tttaaactga attataaact tgcataggtt ttacaaagat

234421
gaatgtgaca tgattcttga cttcagggta ctcgtgatat tagaaggaag acacgtaagc

234481
aaccagtata caagatgctg tgcacaaagt tagcaaaatt taaaaaaagg aaaaaagatc

234541
ctggggaact gagcaagtgg ttcttatttc ttcttaggcg ggtctgggtt ttacagaaga

234601
gatggcctct gagttggatt ttacctctct tttctatcac ttctagattt tatttctctt

234661
ttctaccact tctaacttct tccacctctt cctcctcccc tccctttatc cctcccttta

234721
tttatctctc tcactttcaa atttcaaata atgcattact atgtcccttt accactgttt

234781
taatttctca ttctcttcct ctgattagca aaatgacaaa cttccagtct gcttaataag

234841
aacaaggacg aagatcactg actttttctg ttttttaagg catagcagag aaaggaagga

234901
ctaaaaatat gaacaaaagg tcttttgatt tttatatata gatttctgaa gtttaaatac

234961
ttctgaattt cccaatgcac tgaaatggaa aattttgggc aaaaatgtcc atttgagatt

235021
tgaaagttag tgactcagtt gaggaagaca aacagaaaag ttgctgtaag agagttacta

235081
atgagtggac aagagggtct gagaggcaaa ttcaggggaa agtagaggga aagggtttgg

235141
atgatgagtg tgcttcccaa gattgtatca ctgcccttga cagctctctc acatccagtt

235201
tggtgaaata tgatttgtcg gtcagcaggg gatacagaaa ccagagtgtt ctatgatagt

235261
tatttcaagg cctgcctgaa aacaatacta aggcaatgag agaaatttta aaggtcaaga

235321
aaatataaga aagccattac actgatttta ttcacttaca ggcttgctgc atgctggtat

235381
cagtcattaa tttggtatgc atcattgctg gggttagtag tgattttaat agctgtattt

235441
ctccaatgtc tgcatcatgc agtgaactgt gattggtaag taaggtccct cacttcacaa

235501
cccacttcat ggtgggtatt tatatctgag actaagctcg agtgttctta tatgtgaaat

235561
ggagaaaata atagtatcta cctcaaaaag catcaagtga gataatgcat gaaatagcag

235621
atagctcaga gtatgtagca cacagtacag gctgagtatt ccttatccaa aatgcttgag

235681
accagaagtg tttcatattt caaatttttt cagattttgg catatttccg tatacataat

235741
gagatatctt gaagatgaca ttgaagtcta aacacaacat tcatttagtt tcatatacac

235801
ctgtacatat agcctgaaag tgattttatc caatatttta agtagccttg ttcatgaaac

235861
aaagatttga tggtgttttg actgtgacct gtcacgtgag gtgaggtgtg gaatttttca

235921
cttgtggcat catatcggtg ctcgaaacat ttcatatctt ggagcattta agagtttaga

235981
ttttttttta ttaggaatgc tcaatttcta aatattcctt attacaagaa ccataacttg

236041
accaaaggca aacagctatt aggaaaccga attgggatgc agggctggtg gtattacaca

236101
cggtaatgta tgtggatagt ggcaagctag taaaaggact tttattataa caaagaagta

236161
aatacataag taaataaaag tattctgacc ttaatgagga gttcttgaaa gattcaagga

236221
aaggaagcaa taggattata tagtcattat caaattgttc attgaataac attattattt

236281
aaaagaaaat aatactgctt taaggaattt tatatgatat acaagttttc atgacttttg

236341
aagtttgaaa gatttgtctt ttgttttggc aatgattata ttctaaattc agcaggaaag

236401
ataggttgat tcatattaag ggacactttg cttttacatt tttgtaagaa aaaggaattc

236461
agcccatcct acaataagct aataattgag cacattctct atactagggt caaaataatt

236521
tcacaagtac atcaataaga gagagggaag gacctttaat tattaaactg aagataacaa

236581
caagaaaaaa atgtacaaag cttaatttaa aatataggag atttggtttc acagtaaaaa

236641
tccaaaagaa taaagccaag tagtcactgg taataagaca ttatagattc aaatgagatg

236701
ctgtcttggt caggacgtgg tgtcctccac ggcagaaggg aagaggctgc ctgagcacag

236761
attgtcttga gtatcgtgca tagatggtag agatcagacg ccacagacag ccgtgggctg

236821
tccctttaag aactcccata gaatgggcag agatgtccta gaattggaca ataaggaaag

236881
agtacaagga aggaaaaata aaatctagcc aagctcaagg acctgtatgt gttacctcag

236941
gttaaccaga cgtttctcag aagacagaat ctaaatttct acttacattg cttttgtttt

237001
tattatcatt tttgtgaata ataccaaaat taatgtagac taagtactta tatgggcagg

237061
cactgtgctt agtgctatga tatttctatt tatttatgaa tattatactc atatatttat

237121
agtgatttat actacttgtt tcagtatgca tcaagaaatg gaaggcacag atatcttgac

237181
agagataatt taatataaga aattaaacag gtattgggtg actaaaaagg caaaagggga

237241
cattgaggta acatagaaat ggtaacaggt aacacagacc agtttttacc cctactgttg

237301
ggagaacaaa agaggaagtg gggttattag aatctagggg cttggaggaa gggcgctgca

237361
tggccccaag aggtgtgatg agattggttt tgagtgtgct cgaacagact ggaaatggaa

237421
ccaaataccg ttaccagagt gaagaggcat tgctggagcc atgcattcag gagagagcaa

237481
atcccttctc ctgacttttt gtctaagtgc ctcctatagg aaaaatctgc aaggaatccg

237541
atctcaaagg aaaaaagtag ctccccaagt cccgtctcca gcatcacaaa gcagcatata

237601
caaggatggg tctgaagctg aaacagctta ctaactggca cattattcta tttatattat

237661
gacctattcc tcttcctagt ccagtaaggt agatatgact attcctaatt tacagatgga

237721
gagactgagt tttagtagga tttggtattt tcctccaagt tccgtggatg gcaagtggag

237781
aggcbgggat gctcatctgg tctgcctgac atctctgtct gactctgaag cctaggacaa

237841
gctgcctcta cataggctac taggagccac tgagatggct acaggtttat actggaaatt

237901
cacaaaaata agagaatttt agaaatagag gtgctcttcg atatcttcca tcctatatct

237961
taccttataa agttacagaa attttgagtt actgaagcat gttcagggtc ttatagttgt

238021
taagaggctc ctaatctagt gttctcttca tgtcctgtat tccgcccgta attttcctgt

238081
tgtaatttcc agcaacattc tcactgactg ctcctggaac atttactgac tctgtttcat

238141
gatatatcta tttcacaagg ggaaatggag ttgaagcatt tgggccccat tttaatcttt

238201
cataataatc ttgtaattcc caaatcagct tctcaaatag aatgagagct ttcatgtttt

238261
tttttcctaa attctttttg tatcatttaa atattatgct ttattaaaat attcataatg

238321
gaaaatcata ctttgaaaat tgttattatt aattttgctt tggttggtta gcaaagttct

238381
atctttagtt tttaaaatta atttattttt gaaatagaca ataaaaatcg tatatttgca

238441
tgagttcttt gcttgatcct ctgaacaatg acttcataga ggtgctcact ctgtattgtc

238501
agatgatcta agtatacaac ccagtataca acccagtatt ccatctatca tggcaccatg

238561
gaggaaatca ttgacaaaat gtttttaaac tccttaaaaa ttcataatcc tgacttttgc

238621
aaagcccagg ggtgccaaag caggcatccc tgggcttttg aaaaatgcca ttatttaagc

238681
tagagccgtt atctaggcta tcattatcta ggtagagttt ggggtgtgtg tgacctcaat

238741
atgaaaacat ttggatccac tctcttggat ccaaagagat ggcatctgga ggctgtctct

238801
caaaggagat ctgagcagca cacccagcaa caggatcagc tgaccttgga cagactatat

238861
agaggtaagt tattccacat agaggcaggt gaacagaagc agaatagatt taagatctgc

238921
acttacagaa taatgtaaga taaacacaag catgatctct tatggtacag gagcctattg

238981
gatgggaagg atcagaaaat ctttggggta aggtagggga ggttgtgagg aactaccaat

239041
ctgtagagct tcatctggga accttggaac ctcctctcca tacccatgaa agcgcagtgc

239101
tctgtgactt agatgtatat atcacaactc atccaaattc tcttcagtta atagtagaca

239161
aacaccatac acaacatgca tgatcagcta gtctcagggc ttttcaaagt cagaatttac

239221
catttatgaa acactgtatt tttaaaatat tcttattgag tgcataatga tacatcttac

239281
tgatggtgct ggaaatctgt tttattaaaa tagtaagaaa cagagagatt attatgtatg

239341
caatgaatca aataagcaga aattgtatca tgtaaattaa tagaagcaga agaatgagtt

239401
taagtcagta ggaagaggat gtctttgttg gcaagatacc tggagagaca agggtgatat

239461
agaaatgata aagaagaaaa ggctacacag ttttaatatt cttgtgagga gaaagaagga

239521
ggaactaaag tggaatttgg aaggagcttc agctgatatc agacagtgag atcatatggg

239581
taaaggttta agttgtgagt aaagggaaat gcattctgct tttcaccttg agagcatctt

239641
gtacattgct gatggataaa tggtatgtct actttgcctc cccttttctg ctgattatca

239701
tagatgtggg agatagaaga tatcctacaa tgggcaggag aggagactta acacctatta

239761
tgtgttaagt aggtacatac attaaatttt atcctcataa caactgttta agatggaata

239821
tatcatccca gattattcct tctgccctgc ctgcctcaca tcccatcttg gaggtttgtc

239881
cttaaaggag acaggttaga cacatataga atgttaataa aaaggagata agttctttaa

239941
tcaacatcaa caactctttt cagtaataat gttccaaagt aaaggtgtct tctctcaaac

240001
atatctcagt tctcttaagt tccttcatct cttattgcac tggacacagg tagaggagat

240061
attttgtgat tcacacgtgg aataacacat cttttgtttt agaactattt cagtggttcg

240121
aatgcatctt tatttgaaaa ggtgaatcat tttaggtttc ctgaggtgta gacatcaaaa

240181
ttatgttaca tgcaggagat attgggggag ggaggcgtgt gaaggataaa ggagagagtg

240241
aacaagagta gacaggaaga gcttttagat ggtaatgcag gccctatacc tgtgaaagga

240301
gagagaaaag gaaggattta ggaagagtct cagattgtac tacagttttg aaagagtctt

240361
ggccaggcta acggtgagtc tctaaacaaa gtatgtccat tagataaatt ccatattggt

240421
tagcaataac ccagctccag tatttcccat catgctcagt cattatctag gtagtggttg

240481
gggtttgtgt gacctcaatg tgaaaacagt ttggtccact ctggtgggtc caaggaggtg

240541
gcatctggag gctctctctc aaaggagagc tgagcagcac gcccagctgc taccttgaaa

240601
atgtgactgg gctcctccac tttagatcat agctgttcat attgcbgttg ttgctgttat

240661
ttagtttcaa caggtttcaa atgcagccag aatgacctgt ttcccacatc catcgtctgg

240721
gcctacctcc gtgcbgggtc agcagaggct gaacttctag atcatgaata attcttcggt

240781
ggcatgaccc caagcgagac tgctaagcct cttgtggaca aatttagagt tataaatttt

240841
caaatccacc tagagatacg tctctttccc tagtagcaga gatcataact ttggaggggg

240901
tgaggaccct ctcatctgtg gatgtagtga gattcctcca atggctttgc tgagcagggt

240961
gggctgctgc tcaggcatgt aacgcbggga ctggcagtat caaagggctc tgtcccttat

241021
ttacttcact tcctcaatgt ccagtgtggg tctctttggt tcaacaggct tattaagttt

241081
gattaaaaga agatgcattt catgttctat tctaggtcct agatcacttc ttttgctttg

241141
taagcttctt aatttgctac tcctgagtga ctttatgaca cagctctagc ttgtgacgag

241201
agagattcct gggtctgctt ttagcttcct tggtatttta aacttgggga actgatttct

241261
taaggtctga agtcctagcg atgccttttt tttttttttt tttttttgct ttagtaacac

241321
attttagttt tcatcacctc cctcaggcta cacttggcca aaccaaaagt gagcttttct

241381
tttgcaaata ttagggatgc atatgatcct aatgctatac ttacaatatg aaaacagcat

241441
tccttctttg gaagtgacca tagaaatgag tcttcttttc attaacatag taaacatttg

241501
ttgggcattt gccaggtgcc aggcattaag caaagatgag aaaacccaag gtctctgtcc

241561
tcaggaacat aaagtccgag ggagtagtca aataatcaca aaaataaatc caactgtaat

241621
tgtgccaagt gctatgaagg aaagctatat agtgttaaga gaacttatag aagacaacct

241681
gatgtggttt aggagctaaa ggaaggagac agataaaaga aaatattttt ctctgagaaa

241741
gtaatgttca aattgggctc taaggagtca ggacaacctc tgaatttgaa agaagggaga

241801
gatattctca gcagtaagaa catcaattac agagaacgtg tgatgataag aggtggcctt

241861
attcagggga ctgagtaaaa cgagagagct cagaatgtga agggacatca gaacacaagg

241921
cattggagag acagaaggga accaaagcac gtgggatcct ctaaaatcta gactgcacta

241981
attatttttt ttttttctca gagcaattaa aagtaactta agtggggggt aggtgggtag

242041
taacatatca gacttggatt ttgaggtaat caacagactg tagacgggca agatggctgt

242101
gaggagatca aggaagaatc tttcgatatg actaggttag agactaaggt tggaagagct

242161
aaatttacct ggcaggaatt ttctatatct aaatattggc tgccaaacta atagattaaa

242221
ggatgagcca ttgagttagg ttagaacttc acaatgcatt aaattatagt caataattta

242281
aacacatagc accaaatcat aaatctaata catctgtggt gacaagtaga ttatgtaaat

242341
ctacattcat ttttttccaa gtagctgcaa tatattcttt acattttaaa ttattttatt

242401
tgttcaaaaa ctccttttta aatacataat accaaggcat ctcccagtat aggctgtgtc

242461
cagatgacca cacacgtctc gtttcatgta tgaattcaca aagcttcact ctgaatattt

242521
taaagaacca gcagcaaatt tataactcca gaagtcaacc agccaacaaa accctctaat

242581
atgcttttaa tctcctcctt gcgaaatgaa agaagacaac ttttttttct ttgtggaaag

242641
aaattataca taaaagctca ttttatagca ctgagactgt ctcattttgt taagagtttt

242701
atgcaattag acagtaggaa aaattaaaga gtttttccag tttcagtgtc tctcagacac

242761
ttctttggtg ttttgattca ttaaatccca acataagatt attattgcca cgttactgtc

242821
ttggatgatt tactctattt tattaaaatg ggtagcagag agcagaagaa taaaaaaagt

242881
tggtgtacat gacaatttaa aggagcttat tctaactgag gattgctaat gattaccaga

242941
agcaattttt ttttgttcat tcaatcactc cacaaatata aattgaagtc agatgttggg

243001
aatacaaaga caactaacat atattccctg cccacaggga cattatgatc taattggata

243061
tgcaaacaaa caattgccat gcaaaatgac aatctgaggc tgatgtacat atgtcttagg

243121
cacttgggaa cataatggaa taagggttca gtgtccgggt taactggcat tcagatactg

243181
gactcttgag agagcccagt aaagagaacc tctatttccc atgtgagttc tgaataattt

243241
gtttaaaaag aagaggcaga tgggcaaaaa atttttccac attcattatt aatggaaatc

243301
gaattggagg aacaatccgg aattcttagc caaatggtct tgctgattta gaaccccaaa

243361
ttagccattt tacctctagg gcaacttatt tcctagaaga agaaagatat gtttgggctg

243421
ggccagccca gttaattctt tcccagttta ccaacagaaa tcactatgcc tttcctggtg

243481
tgcagtgagt atagggacag agaaaagctg aggcatattg catcaagtga agctccgtgc

243541
ctctgaagga aatgctgaga gaaaggaagg ggcattcatt acccctatca caactggctg

243601
tggttgagag gtcaacaaag gctttacaag tatcttgaac cagctttaaa gaaagagtag

243661
gaatagagca ggctctagaa tggggcaggc aattgggaag cgaattccaa gcagagagat

243721
cggcatgcac aaaggcatgg aggcatgaga tagtgctatg ctctcaacac ccaagagtga

243781
ttcagcaaag ttcatattta gggagaaagg agggcagcaa gaggtgagcc tgtcatacta

243841
aaaaaaaaaa aaaaaattca aaaaagagcc tgatcaggga gagaatttca ttatgctcaa

243901
gtcagacttt atcctatagg cagcggagcg cacctgagat aggaggaagg agcaggtttg

243961
gggaattttc ttgaatgtgc tatgttcatg cttcctatga gacatgcaag tggagtgaga

244021
tgtgtaatgg cattgggcat agggtctaga attcccactg ttagtgtcag tcgtgggcca

244081
tggcacaaaa ggcaaatgga agtactttct atagaagcca gaagagttaa aaatgcagtg

244141
tagcataatg acaaaaacta ggcatgagat tccaacaaac ctgggtttga atcctgccac

244201
atacgaccta tgagatatta gacaatcatc ctgaaccttg tagttgccat gtataaaaca

244261
gcagtattaa tacctagcta ccaggcttgt ataaaaaata catgagatta tgtgtgtaaa

244321
gtattagcac atctcggctg ggcgtggtgg ctcacacctg taatcccagc actttgggag

244381
gccgaggtgg gtggatcaca aggtcaggag atcgagacca tcctggctaa catggtgaaa

244441
ccccgtctct actaaaaata caaaaaatta gcbgggcgtg gtggcgggtg cctgtagtcc

244501
cagctactcg ggaggctgag tcagaagaat ggcatgaacc caggaggcgg agcttgcagt

244561
gagccgaaat tgcgccactg cactccagcc tgggtgacac ggtgagactc tgtctcaaaa

244621
aaaaaaaaaa aaaagtatta gcatggctct ggcacatagt agattcttct ttaaatgcct

244681
cttcaggata cttagctcat gaaaattccc atttgttgga gggacaagga aacagaagga

244741
aggaacttgt agccagagca agaaagtgga agtggggcag cagccatgtc ccctgtgtag

244801
gcaggaggca gggggacaag agtaccaatg caaggatgga gggatggata cccaaaggaa

244861
ctgcctcatt cacagctgct tgaggggcag agatcactgt ctacagtcct taacacaact

244921
tgattccctc tgctgaaaat tagatctgcc taggctcagc tcagcttcct ctttgtactc

244981
cacactgtct ctgttaagaa ccatagagca cctgtttcat gtctatgaat ctgggttgga

245041
gcaaaaggaa aataaaataa aaaaaactca gagatgagca aagtattagg cagaagccta

245101
atgggtctgg ctggagagga ggagtgtggc catgcgctgc tgtcagcatg cagctcacaa

245161
ggcccgggct ggctgctgtt cttgtgacgt tagttgaggt ttattctggg cataattagc

245221
cttttcactc cttgtttctt tcctgtgttg cgtcctactc catgaaatgt tgagtgccag

245281
tccttgtctt tcatccacac ttgaaacctt cgttcatgct aaggtgtaaa taaccagcaa

245341
caactcagag aaaagtagaa atacacccag acttgaatct tgcagtgtca cctcccctca

245401
cataccctca gcagatatgc ttaaaaaatt atatcttcct ttcctaccag ttttacttta

245461
tacattcttt caaaataatg gtctggcagc tattacaaat taaaaagagt tactaagaat

245521
gaagaaattc aatgatcatc ctggggatag agtgttatct ttcatggtga acatttcttg

245581
gtaatcatga gaaacaccaa agggatgcag ttttaatata atttcaggca acaaataatt

245641
atgaaggaga tgttttgcat gcagagcctt ttggggacct ctgaaatcct gtctcctaat

245701
ccatctatgt atattgggca aatagtaagt tctcaataag tgttagttag aaaagtaaat

245761
gcatgaattg agtcctggta accataataa aaacagtctt tcttgtggaa atgtgttggt

245821
gattatggac tggaccagct gcagcaatca aacagaaatt agagtcttaa tagacaacac

245881
acgagcatgg caccccagag ttggacagaa attttctgtg ctcactggga acttggctct

245941
gactctggtt tctctgtcac agattttggg gtgggagagt gctcccatgg ggaaagcagc

246001
acgtgctgat atcgaaattg aatagaacct tggctgggct aggagtcatt gctattttag

246061
tcacttccag atgtctgctg ctgtagtttt aagggacagg gaaagatgag tggagtgtgg

246121
catgccactg ggtaaaagat gaggagcgtt ctccttctaa gcccttcaag ttgtatttaa

246181
agccatccct caatatgcta caaagatgga ttggataaag cctttaaaaa ctgtgttctt

246241
ctattcacaa tagcaaagac ttggaaccaa cccaaatgcc catcaatgat agactggata

246301
aagaaaatgt ggcacatata caccatggca tactatgtag ccataaaaaa ggatgggttc

246361
atgtcctttg cagggacatg gatgaagctg gaaaccatca ttctcagcaa actaacacag

246421
gaacagaaaa ccaaacacca catgttctca ctcataagtg ggagttgaac aatgagaacg

246481
catggacaca aggaagggaa catcacacac tggggcctgt tggggggttg ggggctaggg

246541
gagggatagc attagaagga atacctaatg tagtgacagg ttgatgggtg cagcaaacca

246601
ccatggcata tgtataccta tgtaacaaac ctgcacattc tgcacatgta ccccagaact

246661
taaagtataa taaaaagtta attaattaaa aataaataaa caaaaactgt gctttttaac

246721
attcatttat agatttgact tcatatatat caaataggca aactgcagaa acctttgtga

246781
actaatcatg actctgcctg ccccaactag aaaaacaaaa caacacaaaa caaaacaaaa

246841
ccagaaccat tcttgggctt tggttatgat ctagtattta tgaagtgcca gccattaaac

246901
atatgttgaa tggtacctat gccagatgag ctggctgccc ccagtagcta ttgtgctaac

246961
ctaacaagct caccagatgc ttgttctata tctgctttct ccttttatga tattttcggt

247021
gtgtctttta atcccaaaat tgtcattatg aattagataa aagatatcag gtggggggtg

247081
accccctctg aaatattctc aaaagggatg cctggggttc tttccaagag gccctgtcac

247141
caccagggac cagtctaggg tatagatcaa agtctgtgat gggttcatag agtttcttgt

247201
ttctttcctt tctttcactg agaaggtatg gcactagcat gatataactc ttgctggata

247261
aagaaagcac aggagaagca gtatagtgca gtggttaagc atataggatt tggattagac

247321
tcaggtcaag ttcagacact gtcactcatt agtcatgtga acttggacaa attacttaac

247381
ctctctaagg ctcagtttct tcatctgtaa aataggtata gtgatagcag ctattgaatt

247441
tttgtgtgtg caggagaggg gaaaattatg gtaaataata attcctccct tgtccaacaa

247501
gattgtgagc tcaccggaaa tataacaaag ggtaagacca gtgaaggtca acatgccgcc

247561
tttattattg ttaaagctga cataaaagaa tgtagtgtct ttatggacaa gtgaacttca

247621
cagccagacc tctctgccag gacaggcctc tccttgcagg agcagagcac agcatgttcc

247681
ctctcaagag aaggaagaga tgtccgcatg tctccatcca tgctctactg tcaaatcagt

247741
cacttttccc cgaggctaga gtgaggcagt ggagggtggc tgggagtgtt atgttaatgg

247801
gtcttcactt ggaagggaac gtcaagagtt ggagatacga ttaccctagt agcagcaact

247861
tcatagtgtt ctcctgagga ttctgtgaga taaaataagg tgtttggcaa gtgctaaatg

247921
ttcacgaaat gtatacggtg atgttacttg tcacagcaac cattatcact gagtgtcaca

247981
tctgtggcaa ggaaataggg caatgaaaaa cagagacatt tggaagttgt ggtgttgtcc

248041
catgagggtt aaataaagag ttcaggatat aatctttaaa ccaaacaaga gattaagtgt

248101
ctatacttag catgttctgt tattgtcacc ctgggacaga ggaacaagca tgaaggttta

248161
agacatgata gaaggagatt ggatttaaca caagtgggaa gaagcagaga tcttaactag

248221
ataaatgtga aacaagaaga tgtcatgcac ctgggagctg ggagatcctc ccaagcatat

248281
tctcctggga tgaagatttc tgggtcttgg ggagttggtc aatccatgtc ttatcttaga

248341
catgagatta gctcacccac tccctctgct tgaggtttct actagctgtt tatccccaaa

248401
tgttctgttg gatggcatcc tagtcagggt tctccagaga aatataacca gtagaagata

248461
tgtatacaca catacacaca tatacatata tatatatata aaatttatta tatcaatcta

248521
gtatttatat aataaattta ttttgattta tcattattat tacttaaatt tattatataa

248581
atctttatat atatatatat gcatataaaa tttgttgggt tttttttttt ttttttgaga

248641
cggggtctca ctttgtcacc taggctgcag tgcaatggtg tgatcttggg acactgcaac

248701
ctccacctcc tgggttctag caattctcct gcctcagcct cccaaagtgc tagaattaca

248761
ggtgtgagtc accatgtctg gctgatatat ataatttata agttaatata aataatagat

248821
ttactacaga tataaaagga gattcatttt gaggaatagg ctcacacaac catggaggct

248881
gagaaatctt ctaacctgac atctgcaagc tggagatcca gagaaaccag tgctgtaatt

248941
cagtctgaat ctgaaggcct gagaaccagg ggagccaatg gtgtgaatcc cactctgagg

249001
gcaggaggag atgagatgtc ccagctcaag cagtgagtga ggcaggagaa aaaggagcaa

249061
atccctcctt cttccttttg ttcttcctct ttttgtcctc agtggattaa atgatgtcca

249121
gccatgctgg ggagggcaat ctactttact gagtccacct atttaactgc tcatcttatc

249181
cagggacacc ctcccgggca tacccagaaa cagtgtttga tatggacacc ccatggccca

249241
ctcaagttgg cacatacaat taaacatcac aagttggctt tattttttct taaactgaaa

249301
aatgcagata caggcctgtg tggcccaggg aaacccagac ctttggtatt tacctgtgat

249361
tcattccgtg cagtcccgag ttaagcacac aagttcctct gagattattt ggagatttta

249421
ttttgttcta gttcttaaag agtacaatat ttaagaaaat ttgccccata ttttgaaagc

249481
aatagttttt cagatctctg ttggcctctg atttgagtta ggcatgatgt ttgtttaagg

249541
caattttcta aattacttct cttaattctt cctctaggaa ttagcatcta cgacatttct

249601
actttctttt ccacacctcc actctccccc acttcacttc ccttcttcag ctgtgagtgt

249661
caaagtccct gggttcgtat aaatgatgtc aaaggcaacc aattgggttt tctaagattc

249721
agggttgact cacctgatct caagaggaag ccccatattg acaagtgatt atcttctcat

249781
ttcacaaaac atagttattg tcagagagaa gtaagagggg agcbggggag tggatagctg

249841
tagtgataca gtaacagtgc ttcaatgctg aaagtgaaaa acacagtgaa tgtgaggaag

249901
agaaaaggtg catattataa aggaagcagc atcagaatat gccaatgttc tgagaataaa

249961
gagggagtta ttcaggtggc tttgagagag ggtgatttca accctggcag ataattttta

250021
ggaacgagaa tctaatgcac aagtaaacat gcttgttata tgggaatgct gtgatagtct

250081
tgatgaatgg gaagtgtgca gatgagttcc aatgtcatcc cacctgctct ttgatatttg

250141
tgaagtgaga gctgagacat aacctctgtg gtttaagaag aactgatcta attatggtca

250201
ggtgattgga aatggaaatc tgccacagca ctttgaggaa gcatttttca gatccccatc

250261
ccctagtatt aagcaaactc ttaaaatcgt aaatctaatg ataccacgaa atgtgttttg

250321
atgtttaaat caaagggcat ttcacggtaa tggctccaca gctgagcaag cctgtatttg

250381
cttaaaaatt ttatctattt agaagtcact gattttcaaa taaactgaaa agctgccaat

250441
caacatggca gctgaaacat tcactttatg gagcaaaaca atagggctca tgtcagagct

250501
gtgacccaag tttgaaaatt aatgtcattt tgttatttct cttaagagtt gatcttttcc

250561
tttgagttgc tcttcacgac aactgctaag tggctttgtt gttggatttc agggtttggc

250621
acaatattcc gttctctttt atggctatta tgacaataaa cgaacaattg gatggatgaa

250681
tttcaggttg ccgctctcct attttctagt ggggattatg tgcattggat acagctttct

250741
ggttgtcctc aaagcgtaag tttcatttgt cttttgggaa gcaaataatg atttctggaa

250801
tcaaatggag ggattaattt ggggattgga tataattttg ttgctatttt atgtctaaag

250861
gaaacagagt ctgtaagaga tgaaatgtag ttttaatacc aacactaatg ttagactatt

250921
acatcttcaa aagaactgaa cataaacaca ggcctttgag tcatctcatg gggtcagacc

250981
aatgcttgca tgcctatctt gtgtttaaac atatttttta aatgtgtatt tttgtacttg

251041
aaggtgtgaa ttaatgttgc cagcaagaca ggaaaacagc tgcbggtctc tcttttgcgt

251101
gcagagaggt ttgtaacttg cagaatcagc tcaataggca gaatctattg ttctctgctc

251161
attttttaaa aaaaccagaa taatcactca ttcaaaaaat tttagctgtg taagacagca

251221
aaaatgaatg gtccccaatg aaaccatcac aatcaactgt ataatcatgg tttgtcttgg

251281
gaaaagattt attggagtat ggggaagaat ttcactggag aactgatatt actgcagttc

251341
atttttctcc ctgcctaaaa ttatttataa tactccactt aaagactgca gaagcctagc

251401
agagttattt gggtttatat attaaaaaaa tgacccttta gccaattttt tttgaactag

251461
tttacgagaa gagttgaaac atctcaagta aggttgccat tcttttattt gactatgtgc

251521
aagttgaatg agcttttccc ctcattgtag gaggtccctc agcctgaggg tctaagaggg

251581
gaaaagtgca aagtcaccct aagcaggagc tctctgaagc agtctgtgac acactttgtg

251641
tcctaaacct gcctcactta cttgttcctc cagagaaaac tgccatattt catttttaag

251701
ctcttttagg acttaaaacc ttataggaaa tcctatatct aagatattta tcaacctgct

251761
aaagtgtaat cagagacctc aaatataaga gactgtccat cagataaact actatcacat

251821
tccaaaaatc gaagatattt tctagtcttt tgactatatt gctctggttg ggctgaagtc

251881
agaggtatca tttacattac tgaggcctca tgagtatcat ttctgtgttg ctcctttagt

251941
ttctgtggtc agtggagaag aatagtttct catgtctgat gactcagctt ttattccggt

252001
aactgtgcag gctgtgtacc ccacagccat tctgcctagg ttcaaatccc agctctacca

252061
tgtatgtatt tatacaatca ttaacagatg gctcaactgc tttgttctcc tgtttcccct

252121
tggtaataga ggtgtaatgg atgtgaggac taaatgaatt aatacaaaca aagcacttag

252181
aatatgcctg gatgagaaaa ttattcaaca aatgttaaca attttattag gctatatttt

252241
attaggctat attatatttt attagcctat aattcatagg cttatttaag aaaaaaagcc

252301
agcatggtag gagttgaggc cacattatag atccccaaaa caaggcagtc atgtatggtt

252361
atgcagttgt acatcagtag atttgtatat ttaataaatg attttctggc agatgaattt

252421
aaagtatcta gagcagcatt gtgccaggca agccacatat ataagtttaa aacttctagt

252481
agtcattaaa taaatagaca ggtacattta attttaataa taaatatatt tgctttaact

252541
caatatatca aaagtattat cattttaacg aacaatcaat ataaaattat tattgagata

252601
ttctctgcct ttcgaaaggt atcaagtctt tgaaatctgg tgtgtatttt ataccagtcg

252661
catttcaatt gttcagtagc cagatgttgc tggtggaaca ctctgttggg tagagtggct

252721
ctagaggaag tagtggcttt ttcaaagttg ctcgaagatg ccatttggga tagctgcagg

252781
gcatcaaatc cacattttcc ccctcaaagt cattcatgtt atatcatcca aaccagtgtg

252841
gccttgaacc ttccctctgg catggacctt tggctgctcc ttacctggtt aacaagtagt

252901
tcaaactcat tgcccaaaca gcaagacaac tcaaaaacaa tacaccactc tcactccacc

252961
accagcccat gggagaatat tcagtagaaa aagaattgat gagatataaa tctttgtaca

253021
gaatcattaa tcatctcttc ctactcctat cccagtcaaa tattctcttg gaataagttt

253081
gagcggattt atgacataca ttactcaaat ggaatagaag gtaacctaag ttctaaaatc

253141
gactaggcta catcaagatt ttttcactgt actcattctg ttagcgtctg catactcatc

253201
cacaaaatgg gagcaaatat ctatttttag ttacttaata gcaaaatcag aaaataaaaa

253261
gatagaaatc caagaaaata gtttgaaatt ttaagataag atgactaact ttgttggccc

253321
aggattctcc tggttttaga actgaaagtc ttgcatttga gaacctttca gtccccaaca

253381
aacatggatg gttggtcacc ttggttttaa gtccttccct tttcttcttc ctcccttcat

253441
tcatttcttt tatccttttt ttttttcctt ttctttccag gtcagtgtac attttcaacc

253501
acatcatatg cttagaaatc ttcatgataa atatagttac ataagtatta aaagcaaatt

253561
aaaacagtat aacataaagt tacacaacat ggaaaccatc agctcattta aatattgtcc

253621
tcattagttt gaagttttat atcataaaat aaaggtggct tgacatcaga acccaactgt

253681
tcccgttaaa aacaattctc taagctaaaa atttggggtt ttactggtct attttacagc

253741
agctaaacta ctggaagcag ttgaatcatt ttgagaatgc atgtcttaat aagaaactca

253801
tagctatttt atccttgtag gctttttcaa gactttttcc tgtttgtagg atgttttagt

253861
ccatttcgtg ttgctataaa ggaatacctg aggcttggta atttgtaaag aaaagaggtt

253921
tatttggctc acagtctaca gactgtacaa gaagcatgga gtcagcttct gcatcaagtg

253981
agtgattcag ctgtttccac tcctggtgga aggcaaaggg gaaccagcat gtgcagagat

254041
cacgatggtg agataggaag caaaagagag atggggaggt gcbgggctct tttaaacagc

254101
cagctctcgt gggagctaat agaataagaa ctcacttact atcccctgca aaagaaggca

254161
ttaatctgtt cataaagaat cttcccctat gacccaaaca cctttcatta ggctctacct

254221
ccaacattga gatcaaatct ctacatgaca tttggggaga caaacagcga aaactcagca

254281
cagggctccc tgggattaga tataattttt ctgtttatga tcctggctat aataatactc

254341
atagaatgga ctaacaaata ttcttggata cttaaatcat gtgctatacg taacccttaa

254401
atggtgtcaa aatttttgtc tacatagact ataatataga ttatatatat atgagatata

254461
tattataaac tacatatatc acaaaccaac ctcaacacat gcagataaat atttttaaat

254521
ttggcaaaat gacagtatgt tcatccatat ttctggagct gcaacaataa ttataaatta

254581
tacttgaaat aataataatt aacatctgtt gagcatctct catgaatcag tttaaattac

254641
attacttcta atccctaaac attgcaaagt agctattagt tttataattt tacagataat

254701
gaaataaaac tcagagatcc taaatgaact gcacaaggtc atttgactat aagacctctt

254761
tgaatttaga gttttctagt tcaaaagata tcttctaccc cttacacctt gccacctctc

254821
tgtactgtgc ttctccttac gtaggccaag gtgttcctcc caccaatctt atatactgtg

254881
ttgagtaccc attagttatt cctattggat ggatggagaa attaaggctc agcagagttt

254941
gaggatttca ctaagttcaa atgcccagta atttgcataa ctgaactttg aacaccttgc

255001
tttaatttca gcacttagct tttctaattt ctgatgtgga ttcatctata ttgatgataa

255061
caatcatcaa tatagactga tgtctctgtc tcgtcctggg tagccttttt atttttaaaa

255121
attctgtatt aaaatagttt cttgtctgtt gttaaattcc cttagagttt tatggccttg

255181
atgtgactca tgtgaccaaa cgttttgtta aaaaaaaaat taaacttatc aaaaccaagt

255241
ccttgttcta caagactctt gcatattcca agataaatca tggccagctt cacacacacc

255301
atttctaaat caacgagact ttattttctt ccttctactt agatgtcagt gcctttgtcc

255361
attttctttt cacttctttg gtacatgttt acccagacag ttatgaccta cctgatactc

255421
tgcctaaata tcttccatgt ctcttgacat ccttaatttc ttaacattga aattgtttct

255481
ttttcctccc cattttccca cccccaatta atttttttct ttgtcgaagg aatttctcct

255541
tatctattta gtagaaagca gtcagagtgc ctcatagacc ccagtctaat attttacttc

255601
tcagagatat tttcattgga gatcataatg tttgatgtat gtaatgatga atttcagacc

255661
ctagagaaag ttatggaagg gtaagtggac ctggcctaca gggcatgata ttctggcaaa

255721
tcccacaaaa catatggtta tctcatcttc ctcaaactat agttgacctt atttcaaaaa

255781
tgcttggagc agaaaagcaa cgaggtatga aagacatgaa gtcaccacct tccattttat

255841
attactactc tatgaattgc atctagattt taaaactcaa cataaaaaac tgtcttcttg

255901
caagcatgga ctaataagga tagtagtagt tcacaaagaa tggcagctat ttacaaagtg

255961
aggtgatatt gtcaaaacct atcataatga caaagacaga actaaacagt gatagaataa

256021
caagcatatg tggtatgcat ttattatatg tattgtgcca tgcaaaaaag caatttatgc

256081
tgtatgtatt tacttggtga ggctctttcc agtgctaagt ttacttctag aatgacaatt

256141
catgtattca ttcatttgat tactatttgt ggaacaccta gaatgggtaa tctaagagaa

256201
ctatccagta cctgggtatt tcatggtgag caaaataaag tccttgcctc tgtggtgctc

256261
agttggggaa atattgtaaa caaagaaatg accagtggtt ttggccaatg tagtataatt

256321
ttatgttgtt gttatcctct gcagtcaaat atttgctaca gcttcttcat cctcaagaat

256381
tttaaatagt tgagaagagc caagatggct aacaagatgc agccaggaag agcttctccc

256441
aatgagaaac cagggtatta agaagattgg cacactccaa gtagatcttc agaagggagg

256501
cattgagagt ggatggagga aggatgtaga ctctgtgctg aagttagagg aagcttggaa

256561
tgctatgctc aggaatgagt tctaggactc attcctggct ccgagtgtct cctaaggaag

256621
ggagagttaa ataggcgtgg agtagcccac tctcaccatg gacctccata attctagctg

256681
caggagtctc aatgaccccc atggatattt gaactgatag ggggagctgc ttgaagagtt

256741
gacagggaca ggactgcaga ctgtgtggag ttcagaggat ttggcaaagg aaggactgca

256801
gtagagcaca gccaaggaca cccatccctg aagactcacc atgcccctgt aggctttggc

256861
ctttgttgac tgtcagacca atacagagca gggctgtctt gcccatggaa tgaggccatt

256921
ctgatctgag tgcctccctt gtctgccagc ctttcctgag gttcatgcca ggctgtgccc

256981
acttgcagca caggcttgga tgtccaactg gggcacttcc taaaggccat catcatagct

257041
tctttgttgg cagaccccac ccaactgttg gagagcttct gaagacaagc ctccacccgc

257101
acacaaccac ctgcagcctc ccccctctgc tttgccaaca cgcaggtatg catggaccct

257161
gctgctctgc tgccaccaac acatgagcac agaccccact gccactgccc cgacaaagca

257221
ctgttgccag caaccctcat ggagcattgt tgttaacaga ctggaaacac ctcagctcct

257281
tcagcacagc aggtgtttaa ccttgagagg ccagagaaca aagcbgtgtg cctggtccta

257341
taccactggg ttacagcaca cagtccagga gtgctgagct gagcccaggt cccctgaaat

257401
cagccagaaa tgaagccagt tgactagacc taacttatat cacagtcaaa acctcaaagg

257461
catcaaagaa ttgcaacttt aaagattaaa gaaacatcag ctcacacaga tgagaaaaaa

257521
ccagcaaaag aactggggca actcaaaaag ccggagtgtg ttctcacttc caaatgacca

257581
tgctagctcc ccagcaatgg ttcttaatca gactgagatg gctgaaatga cagacataga

257641
attcagagtc tggatggcaa tgaagattgt tgagatttag taggaagtta aaacccaata

257701
cgatgaacct aagaatccag taaaacaata caagagctga aagacaaaat agtcatttta

257761
agaaccaagc tgatctgata gagctgaaaa ccccattaca ataatttcat aatacaattg

257821
gaagtatcag gagcagaaca gcccaagctg aggaaagaat ctcagagctc aaaagtggtt

257881
cttcaaattg actcagtcag acaagaataa aaaagaaaga ataaaaagga atgaacaaag

257941
cctccaagaa atacagaatt atgtaaaaag accaatccta tgactcactg acatccctga

258001
aagagagggg gagagagaaa gcaagttaga caacatattt gagggtactg cctatgaaaa

258061
tttccccatc ctcactagag aggtcaacat tcagattcag aaaattcaga gaacccctgc

258121
aagatcctat aaaagatgac catccccaag acacatagcc cacagattct ttaaggtcaa

258181
tgcaaaagaa aaaatattaa aggcagctgg agagaaggga aagacatcta taaaaagaac

258241
ccatcacact aatggcagac ctttcagcag aagcagtaca accaagaaga gattagggcc

258301
tatattcacc atcctaaaag aaaagaaatt tcaactaaga atttcatatc gagcctaact

258361
aagcttcata agcaaaggag aaataaaatc cttttcagac atgcaaatgc taaaggaatt

258421
cattactatc acacttgcct tacaagaggt ccttaaggaa gtgctaacat ggaaataaaa

258481
aactgttacc aactaccaca aaaacacaca taagtacata gaccactgac actataaagc

258541
aactacacaa tcaagtccac ataacaacca actaacaaca ctatgacagg atcaaatctt

258601
cacatatgaa tattaacctt aaatgtaaac gggctaaatg ccacattcaa aaggcacaga

258661
atggcaagtt ggatcaagaa gcaagaacca actgtatgtt gtcttcaagg gacccatctc

258721
acatgcagtg acacccacag gctcaaaata aagagattga taaaaatcca tcaagccata

258781
aagagattga taaaaatcta tcaagccata aagaaattga taaaaatcta tcaagcaaac

258841
agaaaacaaa aagagaagag cctgttattt ttattttaaa ccaaacagac tttaacctaa

258901
caataatcaa aaagggacaa agaagaggat tacataaaga taaaagattc aattcagcaa

258961
gaagacttaa ctgtcctaaa tgtatatgta cccaacactg gaacacccag gttcataaaa

259021
taagttcttg acccacaaaa agacttagat aactacacaa taatagcaag agagttctgc

259081
accttactga cagtattaga cagattattg aggcagaaaa ctaacaaagg tatttgggac

259141
ctgaactcaa cacatgacca aatggaccta acagacatct acagaacact ccacccaaca

259201
acaacagaat atacattctt cttatctgca aatgacacaa actataaaat caaccacatg

259261
ctcactcata aagcaattct cagcaaatta agaaaaactg aagtcacacc aacaacattc

259321
ttggatcaca gtgcaataaa aatagaaatc aataccaaga ggatctctaa aaatcacatg

259381
attacatgga aattaaatag cctgctcctg aatgactttt gggtaaacaa tgaaattaag

259441
gcaaaaatta agaaattatt tgaaactagt gagaacaaag acatgacata ccagaatctt

259501
tgggacccag ttaaagcagt ttaaaaggga agttatagca ctaaacaccc acatcaaaaa

259561
gttagaaaga tctcaaatta acaacttaac atcacatgta gagaaaccag agaaacaaga

259621
gcacaccaac cccaaagcta gcagaagata agaaataacc aaaatcagac ctgaactgaa

259681
tgaaattgag acacaaaaag ccatacaaaa ggtacataaa tccaagagtt gtctatttga

259741
aagtataaat aagattgata gaccactagc tagattaata aagaaaaaag aagattcaaa

259801
taaacacaat cagaaatgac aaaagggaca ttaccaacaa ctcaaaagaa acacaaaaaa

259861
ccctcagaga ttattacaaa cacctctatg cacacaaact agaacactta gaagaaatgg

259921
ataaattcct gaaaacatat aacctcccaa gattgaacca ggaagaaatt gaaaccctga

259981
acagaccaat aacaaattct agaattgaat cagtaataaa aagcctatca accagaaaaa

260041
gtcctggacc agacaaattc acagccaaat tctaccagat gtataaagaa gagttggtgc

260101
caatcctact gaaactattt caaaaacttg aggaggaggg atgcctcttt aactcattcc

260161
atgagaccag catcattctg ataccaaatc ctggcagaga cacaatgaga aaataaaact

260221
tcaggccaat atccttgata aacatacatg caaaaatcct caacaaaata atagcaaacc

260281
aaatccacca gcactcccaa aagtaattta ccatgatcaa gtaggcttta ttcctgggat

260341
gcaaggttgg ttcaacatac acaaataaat aaatgtgatt tatcacataa acagaatgaa

260401
aaacagaaac tacgtgatca tctcaataga cgcagaaaag gctttggata aaattcaaca

260461
tcctttcatg ttaaaaactc tgaacaaact aggcattgaa ggaacatacc tcaaaataat

260521
gagccatcta tgttaaactc acagccaaca tcatactgaa caggcaaaag ctggaagcat

260581
tatccttgag aactggaaca agacaaggat acccaccctc actattctta ttcaacatag

260641
tacgggaagt cctagccaga gcaattaggc aagagaaaga aataaaaggc acgcaaatag

260701
gaagagagga agtcaaacta tctctctttg tggacaatat aattctaaac ctagaaaacc

260761
acatagtctc tgcccaaagg ttcctagatc tgataaataa cttctgcaaa gtttcagaat

260821
aaaaaaccaa tgtacatttc tatacagcaa tattgtccaa gccaaaccag gaatgcaatt

260881
tcattcataa tagccacaaa aagaatataa tatctaggaa tatagctaac cagggaggtg

260941
aaagatctct acaatgagaa ttacagaaca tagcttaaag aaatcagaaa tgacacaaac

261001
aaatggaaaa attccatgct catagatggg aagaattaat attgttaaaa tggccatatt

261061
acccaaaaca ctttacagat tcaatgctat tcctatcaaa atacaaataa cagtttttag

261121
agttagaaga aactatttaa cattcatatg gaacccaaac accctgaata tccaaagcta

261181
tcacaagcta aaaattaaaa aaaatttaaa aagctggagg catcagaatc acactacctg

261241
acttcagact atgctacaag gctacagtaa ctaaaatctc atgatactga tagaaaaaca

261301
ggcacataga ccgtattagt cagggctctc tagagagaca gaactaatag gagatatata

261361
tatatatatg ggagcttatt agggagaaag gctcacatga tcacaaggtg aagtttcgtg

261421
ttaggccgtc tgcaagctga ggaaggaaga agccaagagt ggctcagtct gagtccaaaa

261481
gcctctaaaa cagggaaacc gacagtgtag ccttcaatct gtggctgaag gcctgagagc

261541
ccctggcaaa ccactggtgt aagtcccaga gtccagatgc tgaagaacct ggagtctgat

261601
atccaagagc aggaggatga aaggaagcat ctagtacagc aaaaagatga aagccagaag

261661
actcagcaag ccagcttacc ccactttctt ccacctcctt tgttttagcc actgtggcag

261721
ctgattagat gatgcccacc cacattaagg gtgggtcttc ccctcccagt ccactgactc

261781
aactgtcagt ctcctctggc aacaccttca cagacacacc aagaaacaat attttaccag

261841
ctatctaggc atccttcaat ccaatcaagt tgacacctaa tattaaccac cacatagacc

261901
aatggaataa gttagagaat ctagaaataa agctgcacat gtacaagaac ctgatttttg

261961
acaaagttaa caaaaacaag caatggggaa aggactccct gggtcataca cagcattgga

262021
ataactggat agccctatcc agaagatcaa agctggactc tttcctttca ccagatacaa

262081
aaatcaactc aaggtgggtt aaagacttaa atgtaaaatc gaaaactata aatttttagt

262141
ttttaaaact aatctataaa aactcttgaa gaaatcctag gaaatactat tctggatatc

262201
ggccctggca aatccttcat taagaagact ccaaaagcaa ttgcaataaa aaccaaaatt

262261
gataggtggg acctaattaa actaaagaac ttctgcacag caaaagaatt tatcaacaga

262321
ctaaacagac aaccaacaga atgagaaaaa tatttgcaaa ctatgcatcc aagaaaagtc

262381
taatatccag aatctataag gaacttaaac taaccagcaa aaacaaaaca aaacaaaacc

262441
ctaaaaaacc attaaaatgg gcaaaagaca tgaacagaca cttctcaaaa gaaggcacac

262501
acggccatta agcatataaa gaattactca acattactaa tcattagaga aatgcaaagt

262561
aaagccacaa tgagatacta tctcacacca gtcaaaatga ctattgttaa aaacaaacaa

262621
acaaacaaac aaacaaaaaa cagatgctgg catgactgtg gagaaaaggg aacacttaga

262681
tgctgttggt gggaatgtaa attagttcag ccactgtggc aagcaatttg aaaatttctc

262741
aaagaactca aaacagaact accatttagc caagcaatcc aattactggg taaatatcaa

262801
aggagtagaa atcattgtac tataaagaca catgtactca tatgttcacc acagcactat

262861
tcaaaacagc aaaaacatgg catcaaccta gatgtccgtc aacagtgtac tggatgaaga

262921
aaatgtagta tatatacacc atgcaatgct atgcagccat aaaaaagaat taaattatgt

262981
ctttgcagca acattgatga agctggaggc cattatccta agtgaattaa tgcaggaaca

263041
gaaaaccaaa taacctcata ttctcacttg taaatggaag ctaaacattg agtacacatg

263101
gatgcaaaga agagaacaat agacaccagg gcctatgtga gggtggagag tgggagcaag

263161
gtgaggattg aaaaactacc tattggttac tacgctcatc atctgagtaa tgaaataatt

263221
gatacaccaa acccccacaa catgcaattt acccatgtaa gcaacctgca catgcattcc

263281
ctgaacctaa aataaaaatt agaaagaaaa aaataataat taaaaaaatt atctggggga

263341
aaaataattt acattagtag caccctcttg tcttcagggg atatgttcta agacccccag

263401
tggatgccta aaactaagga tagcaaattc tattgcbgtc agttggaaca tgtttctttt

263461
catgtcttca gtccacatat ttaatgactt ttccacttta actaaatttt aatcacacac

263521
tgtgaccatc acttttacag tttgaggtac aacagcaaaa ctatcattaa tttctttttt

263581
cttcttcaca atttcatgga tagaagattt gttcttactg tagatcttag caacctcagt

263641
gtatgatttt cttttccttc cttattaggt caaaaacttt tgccttttca cttaaaggaa

263701
gcactttaag tcttatctgt ggcatatctg aattgccagc atcactgctc ttgcactttg

263761
agagtattac atgaaataag ggttacttga acccaagcat tgccttactg taatagtaag

263821
tctgataact gagaggacta ttaacaacat gggtatacta ttgtatccac aggatgcatc

263881
cacactaaac aaagggagaa ttcacatcct gggcagggtg aagtgggaag gtgaggaatt

263941
tcatcacagt actcgaaaca tcataaaact taaaacatga attgtttatt tctagaattt

264001
tccatttaat atttttggaa ccatgaattg atcacaagta actaaaacca tggaaaagag

264061
agaactagtc cacatgttgt ttagtatcgc tattacagta attttctttt tcttgtgtgg

264121
tcttatcctg tgggcttcta gaaaattgtt tcctacctgc ctctcaatcc ccttcctctt

264181
ctcaactttc attttagcag aggctacatt atagtgaccc tgttggttta ggatttaaag

264241
aggcatttat ttgatttgtt aaaaacctcc acatgcaccc atgaaataac caaatgacct

264301
cagggtataa atggagctgc aaacttgtcc aagtcaagaa attcagtata aaaaccttag

264361
gcaggccagg cgcggtggct cacgcctgta atcctagcac tttgggaggc cgaggtgggt

264421
ggatcacgag gcagaatatc gagacaatcc tggctaacat ggtgaaacct cgtctctact

264481
aaaaatacaa aaaattagcc aggcatggtg gcgggcgcct gtagtcccag ctactcagga

264541
ggctgaggca ggagaatggc gtgatcccgg gaggcggagc ttgcattgag ccgagatcgc

264601
gccactgcac tctagcctgg gcgacagaga agactcctcc tcaaacaaaa acaaaacaaa

264661
aacaaaaaca aaacaaacaa aaagaaacac cttaggcaac aacatatatg ctagaattgc

264721
ctttgctaac tcccctggca aagcaaatga tgtattgaga ttgcttctca gataaggtgg

264781
ttgaaaatga tagcaatctt aaaaaatgag cagttttcat aaatttgtat acattttgct

264841
ctatagacaa agagtagagc ttatagctat catggccata tctcaataaa aatgtgttgc

264901
aagcaggttt gccttgggca tctttcctta ttcctttcag tattccactt cttttcacac

264961
cctttcccac atgttagatg ttcccagtct gctcattcag ttcgggctcc cttccctggg

265021
aggcbgtctt cagctcaaaa ctttgccagt gataaaactc cattcaaaac ttatctgcca

265081
agtggccatt tttacttgaa gccctgccct tggtcaatga cagtgcaaaa actggatagt

265141
ggcatattaa tcaaataagt cattttctcc ctaggttaaa ccatagggaa tatctgcttt

265201
caaccctttt ggcctccaaa aaaaaaaaaa aaagcatttt gtatggcttt tcatacctca

265261
tggtgtccta gcttgagcac tggagcaaag tcagaaaatc tgagcccttg acttatctct

265321
gtggttcact gctggataat gtccagaaaa ttatttcatg cctttgagct tcagcttcct

265381
tatctgtaaa aaggagagta actaccttga cttcttgctg agattttaaa gagaacaaat

265441
gtgaaagcac acacaatcac catttgcaaa gggtaaagtg gtagatggat gaaaggaata

265501
atgatctgta atttttcctt acatgctagc ctatttaaaa tgtatgagcc tccatgataa

265561
gtgtggctaa tagtggggga atgtagatga tctagagata ccggtcaacc tacaatgtca

265621
gctttatgtc attgtgcccc tttcttcttt ggggtttata tgactataat attttaaaaa

265681
ccaaaacctt atgggaccat tttataattt gtgtcatatg aaattttaat tttgctattt

265741
atagtgaaag ggaaaaaagg aagtggagta tataggatat agatctctaa ccactaaaat

265801
aaacctgtga gtaaatgcat tttaagctct tcatgcaaat acatatatat atatatatac

265861
acacatatat atacacacac acacatataa ttactgatta aaaatatata taaaatcaca

265921
tatatataca tataaaacca cttggcattc aggttgtata aaaatgttga tttttattca

265981
agaattgtag agtagatgga aatttaatgt actcaatgta atctctattt gggatgagat

266041
tctaggggga attaaaattt acataggagt ttctttgcct ggtttagtcc atccagaggc

266101
ttcagatggt ctgggaacca actaaagttg tgtggagcaa tgtaaaagtc agtatatatg

266161
tttcttttcc cctggggagg gattcaatag atttcatcgt attcttaaag aaattcttgt

266221
cctaccaaag gttaagaact aattatctca gttaaacaaa acacataaaa atatgttttt

266281
atatacatgt tgaattattc aaatcttcag tgcttagtag tttattaatc ttgaaggcct

266341
agaaagtgaa taatttcaac aactgaacaa aaataaaatt taaaaagaaa ctattttctg

266401
gtcattagaa caaacttgtt ataaaatata tgtctttttg ctattgcttc tccacttcaa

266461
cactcatgat catgttttgt tgctatttcc cctatctcat tttttctggc tgctgggtta

266521
aacttcctgt ttttgcagaa tgaccaaaaa cattggtgat gatggaggtg gagatgacaa

266581
cactttcaat ttcagctgga aggtctttac cagcbgggac tacctgatcg gcaatcctga

266641
aacagcagac aacaaattta attctatcac aatgaacttt aaggtagagg caccaacttc

266701
aaaaacctgc tgtttgtatt tctaagagta aaattggagg cattccatct ggtccagtag

266761
tgcagtatct tgacaattta catgaaagat taactcatgg tttctgccta ccaagatctt

266821
gccatggttc tgattataac tggaaaatct tccatgaccc acaacagcac tattattcct

266881
taaacacttc tcttctctaa atctggtaat aaaataatgt tactggattg aaataggacc

266941
atgagtaatc agaataagat attttaaaaa ctagaacaat gttcactaat tatttacagg

267001
aataagcata atattgaagt gaccctaaaa cattattttg tagttttttt tttaattcac

267061
tggaatgaag atttttagag tgaagactat cctaatatca gagcaatcac agtttgtttg

267121
caagaattct tccttctgtc ttacttgcca tcgtttgttg gcaatattca cctggtttgt

267181
ggaatctcag atttagttta cattgtcatt cctcacattc tgatgattgt aaaaataact

267241
tttgaggttt tgatactttt aaaatgtagc taagatattc tattttgggt ttttgtttgt

267301
ttgtttgttt tcatggatac aggaagctat cacagaagaa aaagcagccc aagtagaaga

267361
aaacgtccac ttgatcagat tcctgaggtt tctggctaac ttcttcgtgt ttctaacact

267421
tggagggagt ggatacctca tcttttgggc tgtgaagcga tcccaggaat ttgcacagca

267481
agatcctgac acccttgggt ggtgggaaaa aaatgaagtt cgtctctgca tgctttttat

267541
gtgcttagaa cctgacattt gtttcttttg tgggttatgt ttctttgatg gaacatttaa

267601
aaaggccacc ctttacctat cccctatcct gcccttacag ttaaccaacc ctgttgctca

267661
ttttccattc tattctagtc ttatttctaa atctggactg tctgtttttc attttgtgac

267721
atgatggaaa gttagagtca gaaaagatat taaaaaacac atagtctaat cattatgttt

267781
tacagatggg aatgataaat ctcaagagat tgcattatat gtttatggtc acagagttag

267841
gagaagagtc agggtgagaa cctaggaatc ttgacttcga gtccaaggct cttgctgctt

267901
tctctgcaaa tccttcatct gtcattaaaa gatcaaattg ttgcctgaac tttttgaagc

267961
agccatgata aagccactga ttcctatgtt gatctcactg gaaacactca gattgcttct

268021
ccacctttgg gcatgtctgg gcttccctct gttttcatta gaagcctaac tgcagcatct

268081
ccatctccat ttcctcctgt cctgtacctt actttctctc cctctaaatg ctattcaaat

268141
gaagaaggcc agctcttttc caggaattaa acattatgac cgtaatttgc ctttagagta

268201
tctgcccatt tagtgaatca gagaaaggag gttagacata gatcatttag aatcagaaaa

268261
tcattggtca tgagttgttg ctagagtctg ttcccgttca taaaatgctt atgtgtatga

268321
tgtgacgtca ttttgagctt gggcattttc aaagtatgtg cagatttagg ctgtgggaag

268381
tgtagacttc ccacactgaa acttttgcag aacagtatag atcaaaagaa ttaaaatatg

268441
tctttataag catagaattt tctaaaaaat cttggacagc aaatgatata atctacttac

268501
agaaaaaggt tccaaataac attctgagta tttcagaagt ggtaccaata gagacgggac

268561
tagatatttt aaagacttta atatacagtc atgtcataaa aacttgtaaa atataagtaa

268621
tttagcagag ggcttttatt tatttaaaat gaaaaatgta ggaacacctc aaagcattta

268681
ctaagtttgc tttcaaaatg gtctcataat tgtaatagta catagaggta acattatcat

268741
gcagctttgg tccattattt atattggtta tgtttttgta taaataaacc atattaaagg

268801
atgggtagtt gattatcaat aaaataacta ttctttgtaa gaacctcttt aacatatatt

268861
ttagggaccc tctgagtcct aggggccaat gaaggtaata atggagattc atgagtaact

268921
ttacaaattt gataaaacca aatttaaatt tgccttgcat aagtttgcac aggataagcc

268981
aaattttctt tacattagtc taaaattata gcatgctgat tttgtattat gtcatgctga

269041
gatttggatc ctgttggtca tacttatata atgttttaat aaaaatgaca aaaatctaat

269101
agcaattgtt ttctaaatat agtctggtag ttattataat tattcacacc acgaagtcca

269161
caggagaaaa taggaaatgt ttagtggtga cagtttgagc cgggtatttg ggaaaggaga

269221
tagtcaccag agttacctaa aatcggtatt tccctattag aaaattagta catgttttgg

269281
attcttttta ttgacttcct ttagccaaat aatatcatca taaggttgcc aaacatccag

269341
gaaataaaaa gcacatgttt cctacttttc atgtttctat tccttcttct ttctctctcc

269401
cccctctccc cacccctgca ttattctctt gtctctgaaa ttatagccca ttctttcact

269461
tttgaaactt ttctacgttg gcttccataa cattatgtca tgtgttctcc atttgtttct

269521
ctgagttcct tctgtttcct ttaataaaac tcattgtatg tgtttatgtt ttcggcctta

269581
aaagtttaca tttgccaaaa ttcaatattt aggcctaggc ccatctcagg gaattcatcc

269641
attctaactg attaaactag cccatatgct gatgattgtc agattagaat tttcagtttg

269701
aacctcctcc tcaagcagat tattttccat ttcttttgga aatcttgttg tgaagtgcat

269761
caccatatca gaatcagtta ccacatagaa caatatgtgt tctctgtgta gagactgatg

269821
taaattgcca ccttcactat accaggaaac agactgttac tactggcaca tacacacact

269881
cagtcacatg cctctcttga gaatgtgaat tgaatatttt ccctgtcatt ttattgagat

269941
caaattctaa acgtgcataa aatagtcatt tttagtctta aaaaagatca aagaagccta

270001
gctcagaatc ttccaaaatt ctggcaaaaa gcaataataa ctttaaacac cattaaccta

270061
gtttctccct tgtgcctcct tgtagatgaa catggttatg tccctcctag ggatgttctg

270121
tccaacattg tttgacttat ttgctgaatt agaagactac catcctctca tcgctttgaa

270181
atggctactg ggacgcattt ttgctcttct tttaggcaat ttatacgtat ttattcttgc

270241
attaatggat gagattaaca acaaggtaag ccttgtttct ggattgtcct tgccataaga

270301
gtgttgttca attcccagtc tcaagtttgc cagaaatgcc tttgaaatct ctgttgtctt

270361
cattttagtt tctatctctt tgctttctag attgaagagg agaagctagt aaaggccaat

270421
attacccttt gggaagccaa tatgatcaag gcctacaatg catcattctc tgaaaatagc

270481
actggaccac ccttttttgt tcaccctgca gatgtacctc gaggaccttg ctgggaaaca

270541
atggtgggac aggtaatgcc accaacagaa gtgtatggca attagtagat taaaaaaaga

270601
gagtcaatat ctcttccata agattggctt ttaaaaaatt gcttattagt aaaaatagct

270661
aagatttgtt gaatgttgac tgtgtgctgg ctctgaattt catgtatatt atctcacact

270721
gtttgcaaat ctatcccttg aggtaaatac tatttgtatg tcccctttac agttgcatat

270781
aaaggaagga tagttgaaaa tggtgcaaag agatgtttac tatctgtatt ataataaagc

270841
actcgattta gatacaggcc aaagcaaata tttaaatgga actctattta gtgttacttg

270901
tttgctgtaa aacaaaacaa aacaaaacaa acaaacaaac aaaaacagag tcttgggggt

270961
ggccaagaca gccaactaga ggcagctagt gtgcatggct ctcatggaga gaaatagagg

271021
ggttgagtaa atatagcacc ttcaaccgaa acatccaggt acatgcattg gatctaatca

271081
aggaaacaac ttgacccatg gagagcagag aaaagcaagg cagggtgaca gcccacctgg

271141
tagtgacatg aagccaaggg atccttctat gcccagggaa gtggtgagtg aatgcacgac

271201
cttgggaacc catacttctc ccgtggatct ttggaaccct tgtgtcagga gatatcctca

271261
tgaacccact ccacctgggc cttcagtccg acacacagag ctatgtggag tctcagcaga

271321
gcagccactt aagcacatgc agagacccgg gagccttaga tacctgggct tttctttttg

271381
ggcttcctgt caaaagtagc tatacctctg gcaaagcagg aggttagacc cccaaccaca

271441
ccccttagaa aaggggctga atccagtgac agtctgcagg ccccacttca cagcacctca

271501
cagaatgaaa cccactggct tggaactcca gccagttacc ggtagaaatg ttgcacctcc

271561
ctgagacaga gctcctgggg gaaagtgtgg gccatcatct ttgctgtttg gttgacttgg

271621
ccattccatc attcaggctt cagagagtcc aagccaacca gcggctgaag cagaccctga

271681
gcacagcata gcbgttctat gaaaatgtgg ctagactact ttttcaaatg ggtctcctat

271741
ccctttcctc ctcactgggt aggacctcct aactggggtc tccaaccacc tcctacaggt

271801
gcgtttgggc cagcaacggg tctgtacatt tctgggatgg agcttccaga ggtgggggca

271861
ggctgccatc tttgctgttt cacagccttc actgttgcta cctccagata ataaaacatc

271921
tgaggtgacc agggacggat gtggggtccc aatatactgc agcagcccta tgaaaaagtg

271981
accagacttt tacatgggtg cccatcccca tatcggctca ccagacacat cctccaggcc

272041
taggcctcca gctaccctct gctagaatta tcgatcaagt agcagctctg taactccctg

272101
gacaggatcc ccaggggcaa ctgaaagttc ctctgccact acctctgcag tagaactgcc

272161
cttgctaccc ttggactaac aaaggaacaa agaccctaag cgcctcatcc atacctccaa

272221
taagctgcag ttgactccag gagagaaggc cagtctgtct ctcacaggtc ctacctaccc

272281
ccacccccct ccttgtcacc agacagggaa cccccagctc ggacccacaa catagaacat

272341
ccatcctggg ctaattgcaa ggagtaattg ctgacctgca tctcaatggg gtggagcccc

272401
caggagataa gcaaaagacc cttggccata accatgccaa ggtatcttcc tctgctgctg

272461
ccaagttgga gaagaaacat aacgctgaga ttgccccaga gctgaagggg cagcccagga

272521
gtgccaagcc gtaatctaca gccagctctc aagggggaaa gaaatctaca ctttcagagc

272581
attgagaggg aacatggctg caactgtgcg gcaacacagg ggagcctcac aaccaagcaa

272641
gagtctacca actgaccaat atgccgaagt gccacctact ggatcacatt ccccaaagca

272701
tcaacaccaa aaatatctca ctaacatacc cccctctgaa accaaagaca agtactcagc

272761
ttcaaataaa gaccctgtgc aaagccttgg cccaatgaaa acttccagga aagatgccta

272821
ttgactgtat tcaatctaca ttgcagttaa aggaacacct acacactgag atgagaaaga

272881
accaatgcaa gaactctggt aactcaaatg accagagtat tgtatgtcct ccaaacaacc

272941
acaccagttc tccaacaaga gttcttaacg aggctgagct agctgaaatg actgaaatag

273001
aattcagact gtggagagga atgaagatca ttgagattca gaagaatggc aaaacccaat

273061
ccaaggaaaa taagaatcac aataacacga cactggagct gaaggacaaa gtagctgtta

273121
taaaaaagaa gctaataggt ctcataaggc tgaataacac aatacaggaa tttcacaatg

273181
caatcacaag cattaacagt agaataaacc aagctgagga aagaatctta gaacttgaag

273241
actggctctc tgaaataaga cagtcagata aaaataaagg aaaaagaata aaacgggaag

273301
aacaaaacct ccaagaagta tgggattatg taaatgccaa agctatgaat cactggcatc

273361
cctgaaaggg atggggaaaa agcaaacaac ttggaaaaca tattttagga tattatccat

273421
gaaaacttcc ccaaccttac tagagaggca aatttgctgc cagtctttgc taacagtcaa

273481
atttaggaaa tacagagaat tcctgcaaga ttctacacag gaagatcatc cccaaaacac

273541
acaattgtca ggttttctca ggtcaaaatg aaaaaatgtt aaagacagcc agagagaaag

273601
ggcaggtcac ctacagagag aacaccatta ggctaacagc agatgtctca gctgaaaccc

273661
tacaagccag aagcagtcag ggtcctatat tcaacattct taaagaaaaa aaatcttcaa

273721
ccaagaattt catatcaggc caaactaagc ttcctaagca aaggagaaat aagataattt

273781
ttgggcaagc aaatgttgag ggagtttgtt accaccagac ctgctttaca agacatcttg

273841
aaaggagcac taaatggagt aaggaaagac tatttgcagc taatacaaaa gcatacttaa

273901
atacacagac cagtgacact gtaaagcaac catacaaaca agccagcata ataatcagtg

273961
aacaacacaa tgacaggatt aaatccatac atattaatac taatcttgaa tgtaaatggg

274021
ctaaatgctc catttaaaag gcacagagta gcaagctgta ttaaaaaaaa agcaagaccc

274081
aatggtatgc tgtcttcaag agacccatct catgcttaat aacacccaca cgctaaaaat

274141
aaagggatgg aagaaaatct accaaccaag agaaaacaga aaaaaacatg ggttattgaa

274201
attaaaattc ccaatttcaa aaaaaaaatg caaaaaacaa aacacacaca tgcacacaca

274261
aatacacttc aaaccaacaa agataaaaaa aaggcaaaga agggcattac ataatggtaa

274321
agggttcaat gcaacaagaa gacctaacta tcctaaatat atatgcactc aatacaagag

274381
tacccagatt cataaagcaa gttcttagag acctacaaag agacataggc taccaccacc

274441
caataatagc ccaggccctg atgaattcac agctgaattc taccagatgt acaaagaaga

274501
actggtaaca ttcctactga agctatttca cgaaattgag gaggaggagg aacttcttcc

274561
cagctcatcc tatgaggcca gtatcattct gctaccaaaa cctggcagag acacaacaaa

274621
aaaagaaatc ttcaggccaa tatcatgagg cccatcaatt caaaaatctt caacaaaata

274681
cttgcaaacc gaattcagca gcacatcaaa tggctaatcc accacaatca agtaggcgtc

274741
atccttggga tggaaggtta gttcaacata tgcaaaacaa taaatgtgat tcatcatgta

274801
aaaagaaata aagagaaaaa ccacatgatt atctccatag atgcagaaaa agctttcaat

274861
aaaattcaac acccgttcat gttaaaaact ctcaataaac taggtattga aggaacatac

274921
ctcaaaataa taagagcctt ctatgacaaa cccacagcca aaatcataat gaacggacaa

274981
aagctgaaag cattcccctt gaaaaccagc acgagacaag gatgccctct ctcaccactc

275041
ctattcaaca tagtatttga agttctggcc agggcaatca ggcaagagaa agaaatgaag

275101
ggtatcaaaa taggaaaaga gggagtcaaa ttatctttgt ttgcagatga catgatccta

275161
tatctagaaa accccattac cccggcccaa aagcttctta agcggataag caacttcagc

275221
agtctcagga tatatcaatg tgcaaaattg ctcgcattct tatacaccaa caacaggcaa

275281
gcagagagcc aaatcatgaa tgaactcaca tctacaattg ctacaaagat aataaaatac

275341
ttaagaatgc agctaacaag ggaagtgaag gacctcttca tggagaacta caaactactg

275401
ctcaaggaaa tcagagagga cacacacaaa tgggaaaaca ttcaatgctc atacatggga

275461
agaatcaatt ttgttaaaat ggccatactg cccaaagtaa tttatagatt caatgctatt

275521
cccattaaac cacaactgaa attcttcaca gaattagaaa aaaactattt taaaattcct

275581
atggaaccaa aaaagagctc gtatagccaa gacaatccaa agaaaaaaga ataaagctgg

275641
aggaatcaca ctacctgact tcaaactata ctacagggcc acagtactca aaacagcatg

275701
gtactggtgc aagaacagac acatagacca atggaacaga atagataact tagaaataaa

275761
accacacaac tacaaccatc tgatctttga caaacctgac aaaaacaagc aatggggaaa

275821
atatttccta tttaataaat gttactggga gaactggtag ccatatgcag aaaattgaaa

275881
ctggacctct tctttacacc atgtataaaa attaactcaa gatggattaa aggcttaaat

275941
gtaaaaccca aaactatgaa aactctagga gaaaatctag gcaatatcat tcaggacata

276001
ggcacaagca aagatttcat gacaaaaatg ccagaagcga ttgcagtgaa agcaaaaatt

276061
aacaaatggg atctaactaa actaaagagc tccagcacag caaaagaaac tatcatcaga

276121
gtgaacagac aacctacaga atgggagaac atttttgcaa tctatccatc tgacaaaggt

276181
ctaatatgca gagtctacaa ggaaattaaa caaatttaca agaaaaaaac tggatcccat

276241
taaaaagtgg gcaaaggaca tgaacagaca cttctcaaaa gaagacatac atgcggcaaa

276301
caagcatgtg aaataaaact tcatatcact gatcattaga gaaatgcaaa tcaaaaccac

276361
aatgggatac cagctctcac cagtcagagt gattagtagt aaaaagtgaa aaaataatat

276421
gctggcaagg tcgcagagaa aaaggaacat ttatacactg ttagtgggaa tgtaaaatag

276481
ttcaaccatt gtggaaagca gtatggcgat tcctcaaaga gctaaaagca gaactatcat

276541
tcaacccagt catcccatta ctgggtatat acccagaggt atataaatca taaagacaca

276601
ggcatgtgaa tgttcattgc agcactattc acaatagcaa atacacggaa tcaacctaaa

276661
tgtccatcaa tgacagattg gatagggaaa atgtgatata ccatggaata ttatgcagcc

276721
ataaaaaaga atgagatcat gtctgttgca gaaaaatgga tctattatcc ttagcaaact

276781
catgtaggaa caccaaatac tgcatgttct tacttatatg ggagctaaat tatgataact

276841
catgaacgca aagaaggaaa caacagacac tggggtctac ttgagggtgg agggtgagag

276901
gagggagaag agcagaaaag ataactattg ggtactgggt ttaatacctg ggtgataaaa

276961
taatctgtac aacaaactcc catgacacaa atttacctat gtaacaaagc ttcacatgta

277021
ctactaaacc taaaataaaa gttttttttt aatggataat ttggggagca cacactaaga

277081
aattttaata atgtcaattt ttgttaaata attttccctt aaaagaaaaa aaatactatt

277141
ttaagttatt tgttttcatg atgattttgt aaataacccc agcccaagac tagccatacc

277201
ttaccagaga aaagaaataa tgtttcatat ggctttctat cccttaaggg aaaccaagac

277261
aaataaaacc aaacaaaacc caagaaaaat ctacttcaga tctcgtattt ttatacaaat

277321
ccaatttata ttttgaaaag cttttatgat ttcatttagt tagaattgat attcctaacg

277381
tgcagtccat aaattgattt tggggcttca gattatcatt gagaacagct tttgtcataa

277441
agcttctgta tgttagacaa cagttgagtt tagcactgaa tgtagtgttt gtgaaattat

277501
ttgaacaatt ttttactgca ttatttggta agataacata aaaattgaag gactagcatt

277561
agtcttataa aattcatata atttaaacaa atatgtaaaa atatatctta ggcttcaatc

277621
agatgctcat caaacttaag ccaatcaaga tttcaactgt gaaagaaaaa aataagataa

277681
atgtgtaaaa tgctagacat gtatcattaa tgattgagta caaaaattat ggtataattg

277741
aaaattctat tttattttat ttgttaagct ttcgggaacc agataaatcc cccctttgat

277801
gatatatgct attaatttga ttttcagaca tgcacatttc atacaactta caggaacata

277861
ttacatatga aataataaaa tcaaagtcat ctgcacttaa tacaggagtg cttgtgattc

277921
aggatgtggt agacagaata atggccctct ataacagtac acattctaat ctctggaacg

277981
ataaatatgt tacatggcaa aatggacttt gcagatgaaa ttaagttaaa gatctcagct

278041
tgaaagaatt attgtggatt atgtgagcag gcttaatgaa atcataagga tctttataag

278101
caggagataa agggaaaaag tcagaaaatt gagatgtaac agcagaagca gaggttggaa

278161
tgatgtgctt taaagatgga ggaaggagat taagagccaa ggaatgcagg tggcctcaga

278221
aactgaaaaa gaaaggaaac atattctctt cccaagtctg cactttgaat ttagacttct

278281
gacttccaga actgtaagaa gataaatttg cattgtttta aaccactaca tttatggcaa

278341
tttgttacag caacaatagg aaatgagtac atcatggtac ttgggtctcc ctgttccatg

278401
gctttttgaa gtgaagtctg gttgtggtgc ttaacacgag tctgttttat cacaactaag

278461
ccgctcccta aatcttcagc atacgattca agaaaggaaa atataggaag tacagtttta

278521
gaaactgaag gaatttgaga cgttctcttc tgcacatcct agaacacagg ttggcctgaa

278581
agctaagaaa cctgcacttt aacaagcaaa aacatctact gaatgggatt aatagaatta

278641
gctgtaaaga gtaggatctg ggctggccac ttctggagtg aaggaatgga ttaattagat

278701
aggaatgcga atgcaatcta ggagaatatt catgtttcag atgcagatgg ttctgcgata

278761
gtcccacaca tactgactta aaagagaaga aataccattt agttaatcct ccaccttgga

278821
agcccgtgga ttatgctgct tgtctttttt tttttttaaa cctgtctgta gtgattttcc

278881
ttgcttcatc atattttctt actgccattt tagttggatt tcccccttat ctttcacctt

278941
cctttctcca aggaagcatt aagctctagt gggaaagtct gcagaagcgg gccaagggaa

279001
aaggggttgt ggttctgact ggaatgttga ttaggcagat ggaatctctg ggaacaaaaa

279061
gaacatatag gacataacaa atctgagtgc tggcaaggtc tggcctttaa gagatcaata

279121
tctgtatcca tgcatctaaa atttctattc tttaattgct taaaaaatat gcctccaaaa

279181
atagtaaagg cagctgctct gtatgtaatg ttagatatgc accctcattc attgttctat

279241
gagagcatta cagatgtttc ctcttctcct ccatggatac cctctgcttt gattttctcc

279301
aaggatgcta tgagactcaa agcacttatt gttttgaata taggataatg tgattgctcc

279361
tttacttctg cagattccca agcaatcatt tagtttcatc cccaatggat ttgataggtg

279421
ggcagcagag ccattcctct ttgaagctat atcctgaggt cttcactttg gggaagggga

279481
gaaagcaaca gctgaagata aaatggctaa tgtgccaagt atttcctcct caaattttta

279541
cgtttcattc tgagatacgt tatattatta tttccgtttt atagatgaga agactgagac

279601
ttaggtaatt tgctcaagat ctctgagaaa gtcaatgaca ggagccccag ttcagcctac

279661
atagtctgct tacagagttt gtgtctttgt tcacagtgct aaattgtccc ccagttagca

279721
tcaacacaca ctccccaaac tcctgcctgc aatgtctata tttggtggcc ttttatgatg

279781
ttccttgcct attgttttcc cttcacctat taataaatta tttctttagc tttattgatc

279841
aaagctgccc aggcatttta actaacatca cgtgtgcaaa gtttttaggt gtggagtgtg

279901
gggtttagca ggaggcctgt gtgggggctg tgctccccat cctgacaagc acacaaggaa

279961
ctaggatgat atccttgaga ttggctgggc taccattgtt tggattctct ttcttttaaa

280021
atatattttt cctatggtat atgaataaac atttaaaatt tttaatacaa tgtttgaatc

280081
ttcttcagat attttatgtg aaagttaggt cactgcttgg gaaggaatag aatttcaacc

280141
tttgggatga ggatgcttaa gaggatgtgg aggacttcca aaccactctg aaatgttttc

280201
ttacctgagg aagtcttcta gacctggcag tagaaaccta aaaatatccc tcatagcctt

280261
cctctaattg atgctagtta ttagaatctg agctcaacat tgcctggaaa gggtgggcat

280321
ggaggcatgt gtctgtagtc ccagctactc aggtggctga gacaggagga ttgcttgagt

280381
ccaggagttc caggtcagcc tgggcaacat agcaagaccc ctgtctctac atacatacat

280441
acatacatac atatatacat acatacatac atacatacat acatacaaag aactgcctta

280501
ggaaaggaaa ggagacaaag agtaggaagg agaaaaatta tgtccaaaaa taaccacagg

280561
aatactatca ttcattcatt ttttatttat gagtgtacag aaattgctgg gcattgtgtg

280621
attatataat tggaagtaaa acacttctca gcaaatgcaa aataactgaa atcataacaa

280681
acagtatctc agacaacaga acaattagat tagaaatcaa aattaagaaa ctcactcaaa

280741
accacacaac tacatggaaa ttgaacaatt tgctcctgaa cgactcctga gtaaataatg

280801
gaatgaaggc agaaatcaag atgttccttg aaactaatga gaataaagag accatgtacc

280861
agaatctctg ggacatactt gaaggaactc ttcaaggaga actacaaacc actgctcagt

280921
gaaatcagag aggacacaaa catatgtgaa aacattccat gctcatggat aggaaaaatc

280981
aatattgtga aaacggccat actgcccaaa ataatttata gattcaatgc tatttccatt

281041
aaaccaccat tgacattctt cacagaatta gaaaaaaaac atttttaaat tcatatggaa

281101
ccaaaaaaga gtccttataa ctgagaaaat ccaaagcaaa tagaacaaaa caggaggtgt

281161
cacactacct gacttcaaac catactacaa ggctatagta atcaaaacag catagtactg

281221
gtgcaaaaac aggcagacag accagtggaa cagaataggg aacacagaaa taagatcaca

281281
gacctacagt catctgatct ttgacaaact tgacaaaaac aagcaatggg gaaaggattc

281341
gctatttaat aaatgatgct aagaaaactg gctagcctat gcagaaaatt gaaatgggac

281401
cccgtctata caccttatac aaaaattaac ttaggatgga ttaaatgctt atatataaaa

281461
gccaaaacta taaaaaccat agaagaaaat ctaggcaata ccatttagga cataggcatg

281521
ggcaaagatt tcaagacgaa aacatcaaaa gcaattgcaa caaaaacaaa aattgacaaa

281581
tgggaactaa ttaaactaaa gagcttctgt acagcaaaag aaactctcat cagagtgaac

281641
agacaaccta cagaatggga gaaaattttt gcaatctatc catttgacaa agatctaata

281701
tccagaatct acaaagaact taaacaaatt tacgagaaaa aaacatacaa ccccattaaa

281761
aagtgggtga aggacatgaa cagacacttc tcaaagaaga gattcacgtg gccaacaacc

281821
atatgaaaaa acactcaaca tcactgatga ttagagaaat gcaaatcaaa accacaatga

281881
gataccatct cacaccagtc agaatggtga ttattaaaaa gtcaggaaac aacagatgct

281941
ggtgaggctg cagagagata ggaaggcttt tacacagtta gtgggaatgt aaattaattc

282001
aaacattgtg gaagacagtg tggcaattcc ttaaagacct agaaccagaa ataccatttg

282061
acccagcaat cccattactg ggtacatacc caaaggaaaa taaatcattc tgttacaaag

282121
atacatgccc acgtatattc attgcagcac tattcacaat agcagagaca tggaatcaat

282181
ccaaatgcct atcaatgata gactggataa agaaaatgtg ctatatgtac accatagaat

282241
actacgcagc aataaaaagg aatgagatca tgtcctttgc agagacatgg atggagctga

282301
aagccattat cctcagcaca ctaacacagg aacagaaaac caaacaccat atgttctcac

282361
tcataagtga gagctgaaca gtgagaaaac atggacacag ggaggggaac aacacacact

282421
ggagcctggt cgggggtaag ggagaaatga gaacatcagg aaaaatagct aatgattgca

282481
ggacttaata attaggtgat ggattgatag gtgcagcaaa ccaccatggc atgtgtttac

282541
ctatgtaata aaactgcacg tgtaccccag aacttaaaat aaaaaaagaa gacataaaaa

282601
atttaaaaaa atacacaatt caatggtttc taatatattc acatagttat gcatccagca

282661
tcacgatagc attttgtttt aggggcttac aatataccat tgtgcagaca tttaatttgt

282721
tttatttaat tagtctccca agcatattca aatttttccg tttttaatct ggaagaagca

282781
gtactttcat gattgtatgt atagatttgt gcacatgtgc aaatattgct gtcataggca

282841
tttctaaaag tggattttct tgatcaagct ccaaacactt taaaatgtga tggatcttaa

282901
caaatttctt cccaacgttg tgcccggttt aacttcccca tcagtttatg ctcatgctag

282961
ttcaccacac tcaccaatat gaagaagcat ggattttaca tttgtcattc gtgaggcaac

283021
aactcattgt tttcatttgt atttttatta tgtggggttt cggtattttt caattttaac

283081
ggaccgtttg tatatgttct tctgtgaatt tttaatttgt gacttttgct ggtttctttc

283141
tttattggat tgccaatcta tattcatact gatttgtaaa atcttttaat gtgttagcaa

283201
tactcaccct ctatcatata cgttgcaagc actttttcca catttgtctt tcaagtctgt

283261
aaatagtgct attcaccaca taaaatttta aactgctgtg tggccaatat tttcctgttt

283321
ttggctctcg tatcatgttt atgaaatttc tcagtaagaa gaaaactttt gatttagtaa

283381
acgggaaata attatttttt aagtaataaa gtcagggtga aatatttttt atttacttga

283441
tatgactagt tgttttcttc ttttgccatt aattgcagtc ttcaagccaa tacttcttta

283501
gaaatatgac agatttaata ccaacactag gaccatttga agacagaact gtgtgtttta

283561
atagagataa tatctcaaca ggagtttgtg aggctgacag tctctgatgt tctgaccacc

283621
tacgtcacaa tcctcattgg ggactttcta agggcatgtt ttgtgaggtt ttgcaattat

283681
tgcbggtgct gggacttgga gtatggatat gtaagtatga tgttaatttt gctttttttt

283741
ttttttaaat ttatttattt tttattgata attcttgggt gtttctcaca gagggggatt

283801
tggcagggtc ataggacaat agtggaggga aggtcagcag ataaacaagt gaacaaaggt

283861
ctctggtttt cctaggcaga ggaccctgcg gccttccgca gtgtttgtgt ccctgggtac

283921
ttgagattag ggagtggtga tgactcttaa ggagcatgct gccttcaagc atctgtttaa

283981
caaagcacat cttgcaccac ccttaatcca tttaaccctg agtggacaca gcacatgttt

284041
cagagagcac agggttgggg gcaaggtcac agatcaacag gatcccacgg cagaagaagt

284101
tttcttagta cagaacaaaa tgaaaagtct cccatgtcta cttctttcta cacagacacg

284161
gcaaccatcc gatttctcaa tcttttcccc acctttcccg cctttctatt ccacaaagcc

284221
gccattgtca tccgggccca ttctcaatga gctgttgggc acacctccca gacggggtgg

284281
tggccgggca gaggggctcc tcacttccca gtaggggcgg ccgggcagag gcgcccctca

284341
cctcccgggc ggggcggctg gccgggcggg gggctgaccc cccacctccc ctcccggacg

284401
gggcggctgg ccgggcaggg ggctgaccac cccacctccc tcccggatgg ggcggctggc

284461
cgggcagagg ggctcctcac ttcccagtag gggcagccgg gcagaggcgc ccctcacctc

284521
ctggacgggg cggctggccg ggtggggggc tgaccccccc acctccctcc cggacggggc

284581
ggctggccgg gcggggggct gacgccccca cctccctccc ggacggggtg gctgccgggc

284641
ggagacgctc ctcagttccc agactgggtg gctgccgggc ggagaggctc ctcatttctc

284701
agacggggcg gctgccgggc ggaggggctc ctcacttctc agacggggca gttgccgggc

284761
agagggtctc ctcacttctc agatggggcg gccgggcaga gatgctcctc acctcccaga

284821
cggggtcgca gccgggcaga ggtgctcctc acatcccaga tgatgggcgg ccgggcagag

284881
gcgctcctca cttcctagat gtgatggtgg ccgggaagag gtgctcctca cttcctaggt

284941
gggatggcgg ccgggcggag acgctcctca ctttccagac tgggcagcca ggcagagggg

285001
ctcctcacat cccagacgat gggcggccag gcagagacgc tcctcacttc ccagacgggg

285061
tggcagccga gcagaggctg caatctcggc actttgggag gccaaggcag gcggctggga

285121
ggtggaggtt gtagcgagcc gagatcacgc cactgcactc cagcctgggc accattgagc

285181
actgagtgaa cgagactccg tctgcaatcc cggcacctcg ggaggctgag gctggcggat

285241
cacttgcggt ttggggctgg agactggcct ggccaacaca gcgaaacccc gtctccacca

285301
aaaccagtca ggcgtgtcgg cgcgagcctg caatcgcagg cactcggcat gctcagtcag

285361
gagaatcagg cagggaggtt gcagtgagcc gagatggcag cagtacagtc cagcttcggc

285421
tcagcatgag agggagaccg tggaaagaga gggagaggga gaccatgggg agagggagag

285481
ggagtaattt tgcgcttata aggtttttcc tttgtaattc gtcatttaca cacactatat

285541
aagagaaagg catcatagag tttagtggat gggatcaccg ttttaggtgc aataaatgaa

285601
gaccaatgag tacatttata atgcagagaa gttcagactc gagtatcatg gtttacaata

285661
ttctagtaaa attagcacaa gatagcaaaa gcaatggacc tcaacttgtc agctgaaatg

285721
ttgaactcag taaatcttgg ccctgtagcc caccttctcc ctataagttt actagcattt

285781
ctagaagcag ggaaagatgg ctaatatcaa ctgcatattc tatttatgcc tttgaattct

285841
actaaactcc tggatactat catatgccag tcactgtgca gtagatgggg tggataaaag

285901
gatttgataa atatggtact tgcttcacaa agttcacagt ctaataagag ctcgaaagag

285961
acacacacaa gaggctgcag aaggttcaag gaaggcctag tttgctgtca tgcatctggc

286021
aagtggtgga gctgaattct ggcaggggcg gcttcttttc ctgaaacaat ggctcaggtc

286081
tctcagaacc acactggtgc tgactccatc accagctttc cttctatggt catcctcagg

286141
tcccccaaca aagtctgagg gcaacagcac actcatcacc ctgtgattag cacattgcct

286201
ggtttccact gtcctccttt gagtcaaact ggtctcagtc atcctggaaa atatgacctg

286261
gggggttggt agtactcatt tgcttaaaat cttccagtgg cttctcaagt acttagaatg

286321
atttccaaat ccctttctag gccttcagta ccctggatga tctgctcctt ttctttctct

286381
ctcaagtcat ttgctacctc ttttgctctt gctttgtaa gttcacatgg gcttcttttt

286441
atgctcaaac atgggctgct ttttatgctc aaacacaaga tggtccttgc atttgtaatt

286501
gctgtttctc ccgcaagggg tgctgttgcc ctagagctag gaatggctgg tttcttcttg

286561
tcattaaaga ctcagctatt atgttacctc cttagtgctc ttctctgacc acctattcta

286621
atgtagccaa tcaggcactg tttatatcaa cacactgttc tgttttcttc ataagatgtg

286681
catctatttg acattactct tgtaaaatgt actcatggtc tatctccctc tgttagaaag

286741
aatactctat gaaaatagag gccctgacct ctcttatttg aactgtgtga gtcacgtagc

286801
aggcagcatg tgttggctgg ctgtttgaat gttgaacctt ctcatttttg caccatcaag

286861
gcagcactgt ctattgccag aactctgcct ccttcgaagc atgtgcccat ggagtctcag

286921
tgtttgtaat gtttttgagt tattgagcca gtaatgcttc tctcctcacc agtgagggaa

286981
tatcctttat agctgatctt ctatctcttt tatctcctgc cctctagtct ctggatgagt

287041
ccaacagtta ggactgtttt caagatttca ggctagatct gtctggctgt ctgactttga

287101
gatggtacct tttataaggt cgtctccatc accctcattg aaagtgcctc ctcggactgg

287161
ccaaaagcag ttaggtaatg ctcttcggtg aacgacagtg aggtaatggc tacagataca

287221
ggatgctctt gtgttgcttt cccattcttt gctatgaggt attcagctgg cttggtttca

287281
tttctatttt ccttacctga ttcagctcct ctgaggcaga cataaaaatt gccatttctt

287341
ccttagacca ttgcttggct tgtacttacc ttttatccct tggctgcctt cttcttaagt

287401
ggcagaaaat ctgagtgcaa atatgaagtc aatattacat gacctggatg cataaaagct

287461
gtaattaaat gactgtaatt tattatttat tgactgctga cagtgttcct gggttagtag

287521
aaagtacagg aaaaaagaca agttcctgtt ttaggtcaca gagaaggaat tttctcccac

287581
gttacctttg gaaggctcaa aaaagctctg tcagaatcaa aacaagtttt aaaacattaa

287641
tgatggatga cgaatctttg atgtagatcc cattgtcatt gacttaccaa atggatagct

287701
tacacgggtg agggcctact aggtgcaagc cattatgaac aaactctgtg ctaggtgata

287761
aaggaataca gggatgtaga agatgtagac ttacgtagag gttgcaaatt tggcctgcag

287821
ggtagattca gctaatggat atttttgttt ggtatgccca gtggtggtgt ttgtttttgt

287881
ttcatttttt atgagctaat attttaaaat gagagctctt acataaaaac acatggattt

287941
attgtttttc ttgaaaggct ggcaacatta aatctgtatt cccactaggg agaaattggc

288001
tggagttgag aaaccactgc catctgcagt tgggatattc attctccagt tcctcatact

288061
cttcaccact cttttctctt acaagctccc gatataaata gagaaatcaa ttgtatggcc

288121
cttgaagaga aagtgtgtgt gtgtttgtgt gtgtgtgtga gagagagaga gacaggcgtg

288181
catcagtaga aatgcagaca cagaggagga gacatttgaa ctaagtcttg aagaatgatc

288241
aggatttcaa gagatgaaag aaagaattcc cggtggaggg acaagtgtaa gacagagcac

288301
cagagataga tagtgtgggc aatccaggca tagattaaaa aaaaaaaaaa aaaaaactaa

288361
aatgaggctg ttttagagca gaaaaggcta ataagaatgt ttctctgcta ttctcctaga

288421
cctgctaatc aataatatgg tttcagaaag tacctgtcat gaagggaagg acaacctgag

288481
ataggcagag gacatacttg agaattctgt cagaaataaa agataaaatc atggtccttt

288541
ctactgtatg catgcatgtg catgtataca cacacacaaa gcacatgatt tttttcttct

288601
gaattccaaa aataatgcca gtttattgta gaaaatttgg aaaatataac aaagctaata

288661
tgaaagtaaa aatcataggt aatctctgcc actaatgaga ttaattattt ggattgttga

288721
atcaaatagt gttagataac aagtgctaca tatttatata tagtaacaga tttttataaa

288781
tatacacata tatacttttg tatacgtata tatgtgtgta aacaggtagt agagtagact

288841
ggttacttgc ttttatttgt tttacctaac actgatcatt tcccaatgct attaactgtt

288901
gttttgtaac gtttttaatt tgctttaagt tgaactgtct aattattctt atgataataa

289021
gtgttgtgat gacatttaat tatatccatg tacataagta tcttcataga taaatcatag

289081
tggatgtaca aattattttc ttatgataaa tttctctgag ttgaattgct cagtcacagt

289141
agagggcttt aaaaaagtct attcactttt attacaacag cctctgtaga gactctgcag

289201
atttcagcat tagattcaga gatctataga atgctaaagt taggtggatt ttgacacaac

289261
cagttgtaat gcatgtattt aacatatgaa aaattgcatc tgtgaattga aatgaggttc

289321
ctaagtttat gtagccagag aataataagg acaatgaagt acacttctgg acgaaaatgt

289381
tatgttaaat gtattgattt ctgtactggc tctatctgag taagcbgggt taaaagggat

289441
tgtgaatatt tttcaagaca caaatttatg gtcataatgt tatcacaaca aacctatgaa

289501
gattaactaa ggtggaaaaa ttactggctt ggagcagatt accagaccaa tgtaagttaa

289561
tgtaatgtaa gttaatgtct ccaaaggctt ctctgagcac agttctcagt gtttcagaag

289621
agttcatgag gagtagaata gtttgtccct aggaaggatt ttaactgctc taatttaata

289681
caaagtgtgc cctcttgtaa actttgggtt ttctttggca gttcaatgca gaatatcttt

289741
atcttcactt cagttttcat tgacaccatt cttactattt accagcaaag caagtaaaga

289801
atattcaaga agaaatagaa ttagattcag ggcatgatgg ggtaagggaa tgttcaataa

289861
actcagcatg gtgttcacag ttgtattttt aaggtgatca ttgctcactc gtaagtgaga

289921
gccgaacagc gatgggagac ttctttaaag tctgatgaag gatgctcagg attatccata

289981
aataagaggc atataattga ctgactacct tagtggattc ccaatcatat tatattgtat

290041
tatgtcacat ctcaatgtac tgcttatttt gtatcagaaa ctctacaaaa tactttacat

290101
gtattattcc atgtgatcgt accagcaatg ctgtgaggtg gtattattgt tcctacttta

290161
cagtaaactg aggcttagag gatgttaaat aattgctcaa agacacatta atggttagtg

290221
gtagagttag gcctgaaact cgagtctcat caccttcaaa gccatcaacc aaatttccat

290281
catgttgaat ttacaccgta atgcttgact ctagaaattt taaaaattct gccaaaactt

290341
gaataattca tacactaaac ctatggcttt tggaactcaa agtgctcata ggcttaggca

290401
ggctacctgt ggtagaatgg agttagcaaa tgaactggga tacagaatta gaagatcaac

290461
tgttctctag ctgggaacgt ggagatatta tatatcagtt cgggaaggta gaatgataaa

290521
gaatcaggaa gaaatcatca gcatcccata aggggttgag aacatgggaa cagggacaat

290581
gcagactgta ttttaagtgt tccttgaata tgtggacagg atctgtctgc agttaacagg

290641
atcctattct caactagggt tgaagtacaa agcctcaagt gctcaatcat cctagcagac

290701
gaggctagag tttgtcctag atcagtgctt ctggaatttg agcatacatc agaatcccct

290761
gaggacctgt gaaaacagca tttctgattc agtagatctg aggccaggcc cgagaatgtg

290821
cttttctgac aagttcccag gtgatgctgc tgactctcgt ctgaggacca cactcaaaag

290881
ccactgctct ggagccacag cccagactag cttgcagctc taagcagagt gattccagct

290941
gtgagaaatg ggatttatgt gcagaaggtc aggcaactca ttccacaaca gaattaattc

291001
tctctgagat cctgaattgc atttcatatt atccacaggt tggcaatctg cctcaaataa

291061
tgaaacttgc agagagagaa gagatcttcc caggcttttt ctttgtcaag tgagcaccat

291121
atgtcttccc tctgggtgga tgactgactt agcacatcac aagcaaaggt ccaaaaatta

291181
aacaacatca tttccaatcc ctcaactatg atggacttta gcccaaatcc acatgggctt

291241
ttctgatgct ggcccccaac agtcttacca ggaatgagca gtcattagtg agtttattac

291301
acttagctca ttcaaataat tttatgatct caaagttcaa gagaatctgt ttttttttct

291361
ttttccctaa ccgtttttta cctttgagct ttttctattt tagagacaaa caaaatatat

291421
tgcaaattga tttatattta ttaaagtatt gctttaaaaa tttaaaatat aatataacct

291481
aatgtttata aaagcctacc tctaaaacaa tgagcactga cttttatact acatatgtgt

291541
agtttttctg ccttctcttt tgttttagtt ttaaagtgag agcttctgtg tttattgcat

291601
aagttaaatt ccatttctaa ggtgtttaca gagaagcaat tctttcataa ctggttctaa

291661
ttttcaacca ataacgtatt tttagactag aaagggatct tagaaatgaa ctagttcaga

291721
ggttggcaaa cttttgctgt aaagggctag atagtaagta ttttagcttt tgcaagccat

291781
ggtgtctcta ttataactgc taaatgctgt tgttttagta ccagtcatag ataatatata

291841
aatgaatgaa tatagctgta ttccaataaa atttatttgt taaaacaggt ggcagtccag

291901
atttggcaca tgggccatag tatgctgacc tttggtctag ttcatttttg atttatgtgt

291961
caggaaacta agcctaatga gataagtgac ctgcccagct tacctagcta agaaatggta

292021
gagtgaagtc taaaatgcag gtttgaatcc cagtcaaatg tctgttctac aaatccactt

292081
ggtccagtat ggccaccctg tatcctttct gtgcatcagg ccaatttata gatcaagggg

292141
gttgttcctc cagcbgtccc tgctgcaaac acagcaggaa gctagggacc ctagggtgtc

292201
ctttatgctt ttctagtcaa ctagttataa aatgtctcat ctctaatgac cctcaggagc

292261
tctatgtgct tgtgagagag tgaagaaaac aggcatttaa aacgttgagt tttctccacg

292321
ttcagtagtt tggtgggcca cctcatgata ccattctaag gaggcgaagg cttaagattt

292381
gatttttaaa cagagacaga gaaaggctgt tccaaggcaa cagatgggta cgggccaacc

292441
gagtaagcat ttttcagatg tgttctgtga tcacacaggg ctccagggga aaagtgctga

292501
agatcatcca gagcagggca ctcccccaga aggaaaaaga ctcagagtta atgttctcca

292561
gataagaagc agttcatttt tctccatgaa ggacacattt tttttccatt gatgatttca

292621
gcacaaaaac tgtcaaccaa acctttttgc ctcttgtgaa cattgccctt ctagaaagtc

292681
ggcaaactaa cgaaacactt tgtagctgtc cttcaacagt atctagagtg atactgcagt

292741
tatccaggtc atctttgttc tgtttaatac acaggactct ttattatttc attatgtatc

292801
atcctatcat tttaccttga gggttaacca ttcctgttat gccatacttg ctcttctttc

292861
cctgaatctg ttacaaggga gattgtccct atgtttcagt tgaataggag agtaatactg

292921
ccttttagga aagtgatgaa gttgaggcct ggattcatga gactcttgag gccaagcatt

292981
tgaaaattga gaatggtttt gttggagttc caaatcagga accaattcta tctttttaca

293041
aatatatttt tgagttcttg ggtttgggag gaacagaggc tctcttggat catctttgtg

293101
tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgttgg ggagggagct

293161
gttatgggga tatgtgtggt ctgaagcaca cctggagata ataagatctg agcagtgcta

293221
ggaacctgcc aatgtcttgg tgtctttttc gtggtcttct tggccctctc atttcgtatt

293281
tactgcattc ttattccctt attaccagtt ggtcagtctc ctctgattct ctatcccaaa

293341
ttaaataaga gccagtttta ttgcccttgc taattagcat ttactccatt gttagaatct

293401
cctgttagga tgcctaatgc atcaccagga agcctttaga tgggccaccc tatcacagtt

293461
aaccacttcc attctattgg ttttttgtgg ctcctctgta caaaaaacag cctagtgttg

293521
ctgccctgag catgaaggtt aatatccaag acatggagac tggacattga attgagtaac

293581
ttcttaagct ttttttatat ttcttttgct gtatttactt tatgttaaag ttaattcaca

293641
ttttcattga aaaaattttt aatatgcaaa acttgaaaaa gaaaaggaaa actatagttc

293701
atcacccgca tataaagtat gactatcttg ctgattattt tccagtcttt gtgcatagtt

293761
tcatatagtt gattaatgtg tggctttata ttttttgttt aacattagag cacagttttc

293821
ctcatgtaca taaatattct ttcaaaatga ttgtaattca ttgcaatata tcatagtata

293881
aatatactgt atatacataa ctaatgttca acacttagat ggtttcatca ttgcttgtta

293941
aagtttatca tcacatcaga taattttatt aagacagatt ctagaagttt tcttacagaa

294001
tcaaaaagaa taagattttt aaagctttta atatgtactg tcaaattgtt tttctgaaag

294061
gttgctacag tttttactgt caccagcagt gtataaggga gcctgtcttg ctgtactttc

294121
atagcattgg atgacagcat ttaaaaatga gtctcactgt gtttaaaaaa aaaaaggtgc

294181
tttctttgtt ttatttatat ctggttactt atcctagtga ttattctgct attgttgctg

294241
aagggaagta attgaaaccc tagccatgcc tatgcagaac aatttgcctt tcagttttga

294301
ccatgtgaga cgctaatcca atgaacattg tgtctcctct agccttcata caccgaattc

294361
gacatcagtg gcaacgtcct cgctctgatc ttcaaccaag gcatgatctg gtaggccagc

294421
tgttggacag cttatcactt acagaaaagc ctcccaggtt atttttgcat acagcattga

294481
atcctggtgt tagaggagaa tacaatcggt gtctaactcc atatttactt ttgcaaagtg

294541
gatgcctgta tatagtttcc ttttctttca tatcttaaat gtcagtcatc aaaggtgtct

294601
ctctgttttg caaagcactt cttcatcaaa taatgggagt ctgtgttctg gttagcagat

294661
ttatttgagg actatatttt tatattttgt gacgccagga tctaatatta aaacattaat

294721
aattacatta ccacatgata agtatgaaat aaattaacat aaggcctttc cgagagaccg

294781
agtttatttt gttgtcacta ctaaatatat ttaaaatgta acttatagct acttttaaaa

294841
ataatacctt atcaaatcca atagtttatc gagatgaaac gcatgtttta ggaaggtcga

294901
gttaaaatat gatcttcatt ttgtaacttg ttttataggg ccatggcaca tcagaattat

294961
tttttttgat gtgtgaaggg ttgtcatatc ttttatcaaa ttagagcatt ctcactgtaa

295021
acttgacagg ttaagatgag tcgatacagt agaaatcgtt tttgagttta aaaactgaat

295081
cacgacatcc gattcatctg gggaccatgt gtcttggaaa tctgtcactt cagatttcca

295141
gcctacaagc agttacaata aggctacttt atcctgggga catgtgccta agacaatatt

295201
atgctgccaa ccataccatt gtcctattca caagtgccgg tatagactca gtttttgaac

295261
aagtttcata tattgtacca atagatctgt cctgaattat taaacctttg ggtgctgaca

295321
gacaccggac ccctctgcaa atgctaaaac cgtcttgctt ctgtcacaca aagacaactc

295381
tccagggctc catcgtcctg ccatgggatg actgttaaat tcctgtgcct gactaggtga

295441
atcaatatgg aaaagatatt ataaaaatat tgtttcctcc tttgtcaggt aggtttaaaa

295501
atctaatttt tattcccttc ctttctaaat tttccaagta tgactcacat gtccagactc

295561
actaaggaag gaaatgcatc ctacattttc caagcaggga ggaaagtcaa ggtggcccga

295621
ggaacgtcta ctgacacaga agtaaaggga gcagcttctg tgggttctga gctttcattt

295681
cctggagttc aatttgctgt tatggcagaa aatggctaac acggctatgg gagtaatgag

295741
aaaccactgt tctatcagtg gcttttacac aaagtgtcat aaatccttca ggcctcatgg

295801
gtaccattca cgcagacata tgctgcacgt cgattgtgtt ctttcagagt taagacaaca

295861
gattggtcta gaaatttgtt tttattgtca gaaaagctgt tataatggct gtcctgcttg

295921
gtttcactac tgattttgca actatgttag tccactattg ttcatattga aattcttaaa

295981
tatctaacat gtttttccag ttctctcgtg ggcagatcca ttatcaaaat ctctgcactg

296041
tctttttctg tttattaatt cttcagacag tggtcaagct tgcttctggc taatttgaag

296101
agaatattga gttttttgag catacaaaga tattcacaca ctttccaaag ttccagaagc

296161
aaactgacca ttattctatt attcaccttc acgtcaatgc ttggcacaaa tattcttttc

296221
ctaaccctag gaggctgatg agggaggggg atgtcatgta gagggaggtg tggggcaggt

296281
gtaatgtaaa attagtaggc tgactctgca caaaggtcct cacacacaat cgttccatta

296341
ttttatgaag catgaggata taatgcctga gcttaaccat tttctacaga aacaattaaa

296401
aatgtacggg gatgttttat tcaattccat tggcttgtga ctggagatat tgaattactc

296461
ctttaggaat cgctgagtag tggaggttat ttacgcagat gttgttaaca tcaacattta

296521
tagataaaat ccattttgct atgatttggt tgaatgatta gtaaccttta tttacgcact

296581
tattttttga aatacacatg atagtttctg tgctaatatt tttaaatgat gaaagcacag

296641
aatatcttta tcatagcagg atattgagaa atggcagaga acacacagtg agagagaaaa

296701
tgagttttgg acattgctcc aacactgctt cactgggtac tctcccgcca ggtttatcac

296761
ctttttttct tcactttctc agttgatcag atgtgaataa tttacctgac atgtacatgt

296821
cgctgatgta ataaggagag ttaaataaaa gaagctttca ttttctttga tcttccagga

296881
agaaaagaat tttataaggc taaagtgtta caatgatttt tactgacaga tgatgggatc

296941
atgcctgggt aagggactta gtgagccgag ctgattagta atgcatgagt aaagatagga

297001
tgagcattaa cattcggata ttattatgcc aggacttatt tttctagctt atggctcttg

297061
agttatttgt ttaaaatgtc tttgtgatac ttattttgaa attttgaaat ttatttatag

297121
atgtatacac aaataataag catatacata caaacaatgt gcacgtatat aggtacaaat

297181
atatgtggtt ttaggcaagt ctcgattttg aattacgtgc aaaattatat tttagaattg

297241
atcaggttat gcagcaatga aacaacctca aaatcgtagc agctcataaa aggaacatgt

297301
tcaatgtggg gtggaagaag agctttgctc ttagaactta ccttcacttt agagacccag

297361
actgatggaa taggatccat ctgaaacatt gctatcacac tagcagagaa tgaagagaag

297421
gaaaaccaca caggactttt aaagtttcta cccagcagta aggacctaat ttctattcat

297481
actttattgg ccaaaacaag tgatgtcacc acctgatttt taggaagact caaagtgtat

297541
tacatcaaca tgtattggta ttggggagta taatctagtg ctttgcaatt ctaacccatt

297601
agctgggact atcacttgct tacttgctca cttttttggc gttccctctc tcttgctgtc

297661
ctgtaacaaa agtatactgt attgttttaa aatctgtctt ctcattagaa aaaaatagtt

297721
taacttccta caaagtcttt gttcaattca ttatggtaaa atatcattcg tatctattgt

297781
ccgaaatctt gtcaacaaga cagcccaaat tgtgacaata ttccactttt caaataaatg

297841
agttaacttt gggttggcaa aagttcaatt atagtggaaa ctaatttctt catctaaatt

297901
aaaaatgtct ctataatgaa ccaaatttac gttggattgg ctaaacaact attcagggag

297961
tacaaaatgc taaacctagc tataaatgtt gagggcttca ttatagatag gacagtttaa

298021
aagacagggc tccccttaca tttttaaaat aagtgcacat atatcttctt tttgattttg

298081
aaataataaa ttgctattta tattgattta tggtgctaat gaattttctc atccaagaag

298141
agtgaaactt attttgttga aataatcaac taagccatca agtaaaagtg accacaccta

298201
agttgttccc acctaaaagt agtattttaa aatgcttata aaaactcaga tgcacaaagc

298261
agagaattcc caagacaagc taaagtaaga aagtaaacag ataaactaaa tttaaataaa

298321
tgtgtggaat tttcatctca aaaacctata agctagttat aaattttcaa taaaacccta

298381
ttttaggagg cacaaacaca tcattgcaat tggctttaaa acaccatatc acctacaaag

298441
agaaaatgat caacatcaga aagagaaaat ttattttaat ttttttcttt cattaagcaa

298501
aaaacttttt tcatttgtac agtcgtggcc cactgcaacc ttgacctcct gtcattaagc

298561
aaaaactaat tattcatgac agaagtgatt aatgcaaatg tacagttttt ttgagtagaa

298621
gaagtgactt taagggttaa ttatttttaa caagttatat ttataggtgt attagtcaat

298681
gatataagtg ttggggaaag tttattttag aattagaaga aagaagtaaa acaattgtaa

298741
atattgttta ctctgttgta gtttaaattc actaatgata gtaggtatag ttagttacag

298801
catcctttct atgaaataat tatgatatgc aattcctaca ataatgggga aagtggcaaa

298861
atgtgtttag aagttggaaa tagataagtg cagtttcttt atgaaaaggg tttgtctggt

298921
tgaaagtggc agtgtatttt ctgcctttgg aaaagaagca tgatgtcaaa taaacaggtg

298981
cagtgtgact ttgttatgga gtaaagactc aaaactgagc agagttctgt tttctttcta

299041
ggatgggctc cttctttgct cccagcctcc caggcatcaa tatccttcga ctccatacat

299101
ccatgtactt ccagtgctgg gccgttatgt gctgcaatgt tcctgaggcc agggtcttca

299161
aagcttccag atcaaataac ttctacctgg gcatgctact gctcatcctc ttcctgtcca

299221
caatgcctgt cttgtacatg atcgtgtccc tcccaccatc ttttgattgt ggtccattca

299281
ggtctcttgc ttttgaaatt tgactcaggc atcgtgttct ttcgggggtg gaggtgggaa

299341
tggtcattca ttgtataagc tattttttcc ccccaaacaa tgacattttt ggttggtgga

299401
aatgagatcc cggctgggcg cagtggctca tgcctgtaat cccagcactt tgggaggctg

299461
aggcaggcag attacctgag gtcaggagtt cgagacaagc ctggccaaca cggtgaaacc

299521
tcgtctctac taaaaataca aagaaaaaaa aattagtcgc gtgtggtggt gggtgcctgt

299581
aatccctgct acttgagagg ctgaggcagg agaatcactt gagctcagga ggcggaggtt

299641
gcagtgagct gagatggtgc cattgcactc cagcctggag gacaagagca aaactctgtc

299701
tcaaaaaaaa aaaaaaagaa agaaatgaga tcctttgggt attcaggttc aataggtgac

299761
atggagattc ttaggcaagt tctgtctatt tcctcatttg ggaatcataa aagagaaaat

299821
actttatact tttccaggct ctgcctgggt aaaatatgta tggtgaatct gagctgtttc

299881
catgttagag gatagctaag agcaaggtct gatgacagtg gtctggatgt gagtttgcct

299941
gactcbgggc cgtcacatcc agacgtggtc agctatcact acttctcttg tgcattacta

300001
ccttaaaaag agagagagag agacagacag agagagagag aataccccac actttaccta

300061
ggaaagagaa ttattactaa atactaatga gcataaggag ggccacccaa tttgttatcc

300121
aaaatatcac atgctagtga aaaaaattaa ggcbgttcca catatatatt ctctcctaat

300181
tatcattcaa gtcaggaatc gagagtcaca acggctcctt gatccaattt agagatacac

300241
atttctacag ttctctatga cagagctctc ttctctctat gacacatatc agaaacctaa

300301
gtccctggga tctggaggat gaagtttctt tccctaaagg gccttagaaa tgaatctact

300361
acaagttctc ccaagaatct ctgcatgttg attcactggc cagcatgcac ttgagctgtt

300421
tctccttttc agtgaaggaa atgagactgt aaaaagccat gtgaatgata tgcatgatgc

300481
tgtaatgccc acatataatt cctccattat gttgtcagac ccaagttatt taattaaagt

300541
caaaaggttc attgctgaca gactaagtat ataagagaca ttttcactct taacagtagt

300601
ctgagttatt gctttgctgg aaaacaagaa aatgttaagc cagctgatcg agttaaacta

300661
gctggacctc tgtctactca gagaactgat gttgagaagc tctgttaatt ccgttgtgtg

300721
tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tttccaagtg ggctgaaata

300781
aataatgcag acagtgacat ctggagacta aatatgaaat tacagtcttg atgagacatt

300841
cgtctcaata aattccgaac caatctcaga gtacaaagtt caaggaatat gccattcaaa

300901
ggctttagtt aattgcaaat tattcacact acttattatc caggataagt ttaggtgtgc

300961
attaagctat taattggaag ttgatccttc tcagtaaaac atagcaaagg accctagctg

301021
cctgtaaggg aaaccacaca atgtaaacat ggatctccac agatgcattc agatttacaa

301081
tacgtcttag acatgaacaa tagttgcaca atttcagctt cttaagccct aactcttctg

301141
gctttcctaa ttggcaaact taggcaaaat tatggcatgt aaatcactat tttgaaatca

301201
gggaaattta ttttttattt ttaaaattat ttatttgttt tttaatttcc ataggttatt

301261
ggggaacaag tagtgtttgg ttacttgagt cagttcttta gggtgatttg tgagaaatca

301321
gggaatttta aatattttca atggagtact gggaagggtt atctctatgc tatttagatt

301381
ttttttttca tgtcagtttc ctcactttag agccaaagga tgtttgcatt gtttatttgt

301441
ctggacttaa aagtttgaaa ggattgtcct gctctagaaa tgaggtgaga atgcttgtat

301501
gcttgtacta gtgggtgcct catagcttgt catctttatg aaccccaagt tttaggtgat

301561
ttgcttaacc ttcctggtga aggttgtctg actctatcta gatcctgggc aagcaggaat

301621
ttaggaaata taaatttgaa ctaggttact ggaggtatca cagtgatggc tagttgctct

301681
ccagtgtagg gaagttttca ggtaagatgg ctatagtata tttatccatt cagtaaagca

301741
atttgatgag atattctagc ttgtctggtt ttataagacc tggctagaga gggtaaattt

301801
tccaagaaat tattccaata ggctagtaag tggatttatc gtaaatagtt gacaatttaa

301861
agatgtccag atgaaggcaa ttctaattgt tctatagcat ttcctgacac ctgatgtttc

301921
ctcccatcta tgtcaataat tctgaacaat ttatagttct ctaggttttt atatacatcc

301981
ctgcttacat tatgacaatt ttatttttca tatattttca tcttactgca aagataatat

302041
gtgtttatgc tagaaaacct aaacattgta gaaatatttt tacatgaaaa gaaacatggc

302101
ccataatctt gaaaacctga aataacaact ttttagcatt ttatattctg ttttgccttt

302161
catgcatgat ttttcataac tgagcttgta ctgacacagg atgtttctca gcctcttcac

302221
tggactcaca gaggggcacc ctgtctactc ggcctgctgt gcttaacccc ttgtgggagg

302281
aagcacgtgg gcaagtgagt gcgggatctg gcgagacaca ctgggcactg acacaggagc

302341
aagctccatg tggggcccgt ggccagacca ggtgtgtcac cttgaggaga atgcaatggt

302401
gcccaagtgc ctatgaccct aaagccccag agggggtgtt acaatgcttc ctgagttcca

302461
ccatcctcag cctgatggat ggcagtgtct tagcagctca gttggcccct tgcctcatca

302521
tgtggggcag ctgccctcca ctggagaggg caaagggcca gtgtgacagt ctttcctggg

302581
ttcccacaat cggtgggtcc caagctcttg tccagcatcc aagaagaatg aggtcacatg

302641
gattattgaa ggatggtgaa ggaggagaat tttattgagt aatgaaattg gctctcagca

302701
gagagggcag ttggagaggg gccaggaagg gcaggtcatc ttccccaaag tcaggttgtc

302761
tcttctccaa agtcaggccg actcttcccc aaagtcaggc cgtctctccc ctctaccaac

302821
tgagtctgtg gtctttatag gcacaggatg gaagtgtgtg ctgactggtt tgtgagtatg

302881
caaaaaaggc taaagtgaag gtgtcactca aaggtagaca cgacagtata gaaacccaac

302941
taggaaaggg taggtatatg taaaataggt gaagggtggg gatgaatcag aggaaagtgc

303001
gccaaacagg aagacaagtt ctcaatccgg tctgaggatt taacttggac cttggctttc

303061
aggctttaaa ctgtctttgg cttggaggtg gcatttcacc aggtacctgc ccctatctgc

303121
ctaggcattt ggctgcctcc tgttgctatc agtatactag gtgcaggttt tttagtatta

303181
aaagttaaaa ttatattgtg agactgctat tatattggtc atttgcaatc atgctttatg

303241
catctatttt tcttaatagt ttagctgact tctagagatt ggggatagag aagtttcctc

303301
tctgtggatc taggacacag taaagtgctg gtcaataatt tgaatgaatg aatgaataat

303361
gactgcttat tgtgcactaa gcactagaag agacacaggg ttaagtccat gcattaagca

303421
ttgattctgg tcctgtggca cttatcaccc agcbgggaag acaggcctcc tcataaactg

303481
ttctaatcta gagtggcgct atgcctacag caggactatg gatagacaca gacaactgga

303541
aaacaattct gagaatattg tatgatagca tactttggct aacctggcag gagaaggcat

303601
tgccagggac atgtagatgc gtccataatt tgtacgtaat taagatatct ggactccttt

303661
ctttggtaaa agacctgacc tgaaaaaggt acacaggaat ccccagggac ttagcaactt

303721
tgctttgggt cacactggat gctgagaagg cctttgtgtg tagggataat ttcataaaat

303781
ttgaatgccc ccactctaac tacgttcatc agctatgacc tgaggtgctg gagaagggag

303841
gatagatggt cttatctttt ttggtacttt taatttatct gcttatcctg tattccatct

303901
ggcbggggct gcattggggg gtatgaacaa tttggaatgg tgaaaaataa aacatattgg

303961
aatagggagt tataatctta tattgcttgt aagcttcatt ccctcttatg tatcataagt

304021
cttgaaaatt agagtgtaga tctttaattt gtgaagcaaa acttgtacct ctgtagtcca

304081
atgactactg acaaaatata tggagtcact atgtctgctg gaagatagta ttggttagac

304141
caggagaaaa aaaccataat ctgggacttg cgtgtcattg ttatttagta gttgaaaatg

304201
cttaaagatt aaaatacaaa agcaaaacta aacattgtat taaatgttgc accaacattt

304261
attctgatga tgcatacaat ttggtgaaac ccaacccaaa tctcttctga aaattacatc

304321
ttttcgtagt acaatcagta tgcatataca gagaaaataa tgatgtaatg aatattttga

304381
atattatggt acaattctag ctattcctta gtaagtcaag acatcctgtt ctcagttttc

304441
tagtttatag gagctgatac ttgccttcat ggagcttagc agtggagcta agctggtatt

304501
cattagggcc tgtccaggag aagaaactga gagggaaaaa acccatgatt cggtgtggtt

304561
accttaccta ttaacatatc tgatgaagga agtctggtgg aaaatgaggt ggaagctatt

304621
gcgtggaaag agatattgga ttatatgtgg attttattcc actgggctat tccttgctct

304681
catttccaag gctaattaaa aatacttagc tcaaagagag tgttctccta caagagcagc

304741
tgactgagag gcagacttat gagctattta caaaatatat ttcaatcaaa atcttagaaa

304801
tacagttttt aaaaatcttc tcctaaatat gtggttaatt ttctaactgc tttgactata

304861
tgtttatact gggatcatat ttctcgtatc ttacccatat attgactaca tgaggtcaaa

304921
gtgtcagcaa gttgtagcta aacatcagat tcctaccctg aaagaggacc taagcagtaa

304981
ttgagaaaga tttccagttt tcttgcttta accatggttt ttccatatgt tcttaataaa

305041
cttatctccc cctttttaat tcccccagtg gcaaaaatag aatgtttgaa gtcattggag

305101
agaccctgga gcacgatttc ccaagctgga tggcgaagat cttgagacag ctttcaaacc

305161
ctgggctggt cattgcbgtc attttggtga tggtgtatgt gcttttcctc ctcatagaaa

305221
gagcctctgt gatgttcttc ctggctgttt ttacatttca gctttttcag ctctctcact

305281
ctccctaagg gttctgctgt aacctatcca aattcaacac tgattacatg gtggtgagag

305341
gctaaaattc atgagccata ttctgatcct attggatgta attcacaggc atctgcatct

305401
gtctttgctt ccccaggatt ataagatttg ttcccaagta accacaataa ttatccataa

305461
acagctaaag caagggaaac ataaatgcta aatgctaaat ctaatcagta cattgagctt

305521
ccccccaaca acccggcctc cacctctcgt tccataaagc agatggcaat gaatatacag

305581
aaataatgat cctctaagtt aatattcccc ttgggggccc tatagactat attttagggg

305641
caagggcttc aagggtctta aaaatttcac tgtccttgtt gttagagggc cgccaataac

305701
tgtgtgttca cgataataga atcagaggac cagaggatct tgggaagttc ctgtagtctg

305761
tcccttcaaa gtcagaagtg atttccaaag gggaacttgt cagatgactt ttgttttcac

305821
ataactttca ttggcttctg actcttggcc atcacagata aacttagatt ctaagtaaaa

305881
gtacagattt gcbgtggaag agccaaaagc agcgtccatc tcttcctttc agtccctgag

305941
tgcctcctac atagaatgtc tggagctgcc acgactctca gtcagtgggt aaatattaaa

306001
cagccccagg gacactttaa gaacaaagtt gatgcaaagg atttggttca tttaaataaa

306061
ggtaaaacaa ggaaatctca gggagaaaac tcccagtggt ttgcagtaaa tgagcaggga

306121
ttgtgaccca gttattgtcg tgatcacaag ccacataaag tagtgagggc aggtttatct

306181
tcttcaattt tataacctaa gaaattgatt tacacaaaga aagtgatttt ccctagacaa

306241
gagagagagt aaaatggtca tagaaggacc tgaagcagat cctttcacag taaatccagt

306301
gctcacttct ttatactgcg aggctttctg tgagggagag ctaataacct gtagggataa

306361
ttaaacagta aatcagatta ccattatata ttacataacc ttgataatgg ggtgctatta

306421
agaatctgat agtaaatctc tggcacagat gcattagaaa atgacctact gaatgcagca

306481
tgtttcacca gatggccttt gaaacaattt tctttctcta catgtccatg atacagtggc

306541
ttctgagagc atgttaatca gtatcctgtg gcctttgaga gtcaaggccc tttagtggta

306601
tgaatgaggt gttgtttaaa acacacacac acacacacac acaatgtaaa tgtcagattt

306661
cgttaccata ttcttacttg attaggagac atgtttattt ttaagtgaag gagtggcatt

306721
gttcaaatgc cttaatccaa agatttagta atcagtccta agagggttta aaaggaattc

306781
acactgcctt tgtttcaggt actatttaca cactgactca tttaattccc ataacagctt

306841
tgagaagctg gcttcattaa tcatactatc aataacacat tgaaattctg ccccaagtca

306901
agtgactaag tggaactgaa actcatgtct tctccttatt tcctacactc acttgcagca

306961
ccaaacaggg atcagaatca gtgggaattt cagatgggct gaaagccact tgtccgaggt

307021
ggtatagacc cagggtcagc acacttttcc taattcgagg gccagaggca aattaggcca

307081
agaggcaaaa ttgaggctct taattaagta attactaata ataaccgttt aaaagacaga

307141
aaaaccattc ttaattcatg ggccatacaa aacagtctgg cagtcatctt catcctgcag

307201
gacctagttt gctttgatct ggacagcctg gaggaaagct ggccccatgc aaatgtcaaa

307261
tagatgtact gaaaggttga ttgtggctct gaggttctga tttaaaaccc agattttagc

307321
ttattactga gtatattttt tcaaattctg agatctcatc ttctattttt ggggcccata

307381
caattggctt agctttttat tacctttaat tagagaattg tactagtatg ttgaatttcc

307441
cccaatggat tatattaaat caacctggat ggctttcggg tatctaagca gagttcaggt

307501
tagttctctg caggcagttt cattcctttg gagactagaa aaagatttgt gaggaatact

307561
tatttaacgt gcattacaag gtagaaaatc atggtggata aatagagaat tccagaactt

307621
gaaaggactt gtgaaatctt tgagttcatc ttccaaatcc aggaactttt ctaagaaaat

307681
ccttataata cacaccacac acaaacacac acacacacaa acatttattg agcacctatt

307741
tcatgccaga tattgccctg catgcattta tgtatgtaat tttagtaaaa ctcccatcac

307801
tcatgtaaga gataaacaaa ctcagccaaa ccgtatcaat aattgtgttg ctagcaccag

307861
atggttcata aaggatactg tctttcattt tggggagtag aggaaatgtg ttcaatatcc

307921
agttatttgc agcaaagagt aatataagtt acctttttta ctgcatttct tctttgtttg

307981
tttgttcgtt ttgccttaag tgaagataag catatttatt tttacagaat tgtctggcta

308041
gaatttgccc tttctagaat gtaaatgtca tttaaaatcc aataatattc ctttatacaa

308101
cgttttcttt ttgagggaga aagaaatgca aacaatacat tctacggaaa aaattccatg

308161
ttcattatct atgcctatga ggattacatt cttagctgca aaggccaaag gacgaaattt

308221
aaggcagaaa gtcgttttcc tttttgttcg gcatgttccc taagctgcag taggttttcc

308281
attctctggg atgccattgc catccattta aaatgctact ttcaattata atttaaactt

308341
atgtgaatac atttccagga aaaagctaat attaggcagt gtgaaatagc agacagaaca

308401
ggctgtggat caggagcctt gggccccaac tttccaactt caccccagct tcatccctat

308461
gtcatcctga atgtatctct ttacctctct ggacctcagc ttttatctat aagacaagag

308521
atttagagta gaagatagct taatgttcat tcccatgctg atatttcata atttacttaa

308581
tgtaaattta agaagtatct tggggaactg aaatatacct tacactgtat tttttttctt

308641
tttaatttag tttggccatc tattatctca atgctactgc caagggccag aaggcagcga

308701
atctggatct caaaaagaag atgaaaatgg tatgatacaa tttatttcat agaaatatta

308761
tctttattaa tgtcaagcag tagaaaacac tgagaaatct acttttttcc ccttattttt

308821
tattgtgtag caagctttgg agaacaaaat gcgaaacaag aaaatggcag ctgcacgagc

308881
aggttggaga tacgtttatg tttgtaatgt ttgtaatttt tctttttctt tttctttctt

308941
tttttttttt ttttgctttt tctccattgg atggtgagtg gcattattgc tgtgagcgag

309001
tcattccaca atccttacct tccacctttt tagcccttct caggcatcac atccagggta

309061
tttggttgtt ttctagtggg aggaaaaaaa gagaaatgaa aatgtgggca tataaacttg

309121
gcagtagtga tttttaaaag tgaccttgaa aatgcgcaga aaatgaagaa atcccccata

309181
tagtcgtcta caaacagcag atacaaatgc agatgctctc ctgcccatgt tgactatttt

309241
catacatgga aggatatggc aagaagatcc caagagggtc ctctgggctt tccaccactg

309301
attgccagaa gccctttcta atccattaaa ctttcttttt ttaaaaacct ctttattttt

309361
taaagtatta gagtaaagcc aacttctagt tgccaaaatt aataatatgc tttgagttcc

309421
ccacggaaag gtgataccta agacctttag tgaaaatctt ttccaacttt gtccttactc

309481
ctaactttaa aactctttac attagtagga ctgtttcccc actgtaagta ataaaacact

309541
caaattggtt taattgagaa agagtaattt attcgaccac acaaatgcag ggaaatggta

309601
tgtatggctt caggccactt tcttttttct atatatatat atatttttta attatacttt

309661
aagttctagg gtacatgtgc acaacgtgca ggttagttac atatgtatac atgtgccatg

309721
ttggtgtgct gcacccatta actcatcatt tacattaggt atatgtccta atgctagccc

309781
tccctgctcc ccccaccgca cgacaggccc cggtatgtga tgttcccctt cctgtgtcca

309841
agtgttctca ttgttcaatt tccacctatg agtaagaaca tgcggtgttt ggttttttgt

309901
ccttgcgata gtttgctgag aatgatggtt tccagcttca tctatgtccc tacaaaggac

309961
atgaactcat cattttttat ggctgcatag tattccatgg tgtatatgtg ccacattttc

310021
ttaatccagt ctatcattgt tggacatttg ggttggttcc aagtctttgc tattgtgaat

310081
agtgccgcaa taaacatacg tgtgcatgtg tctttatagc agcatgattt ataatccttt

310141
gggtatatac ccaaaggatt ttttttcttt tttgagacct ggtctggctc tgtggcccag

310201
gctggagggc agtggtatga tctcggctca ctgcagctcc aacttcccag gctgaagtga

310261
tccttcctcc tcagcctcct gagtagtggg gacagcgcac accaccatgc ctggataatt

310321
tttaattttt tttttgaagt gaggtcttgc taagttgccc aggctgctct caaagtcttg

310381
ggctcaggtg atcttctctt tttggcctcc caaagtgttg ggattaaaag catgaaccac

310441
tgtgcccagc attcagggca ctttttatcc taagtttaga acagagtcag gtctgagccc

310501
acctctctgt gaatctctga agctaaactc ctttcacatt ggctgacctt tatggcagca

310561
ggaatggatg cagcaacttc caatgccatg tccttagact gtaaaacttc tttcctagaa

310621
attcctcaac ctctcctcct ttcagattgg ccccatatgg gtcatgtatc catccttgtg

310681
ccagtcactg tgtctgagta tggtaagtta ctgaagtcag tcaggaccca tccttgaagc

310741
tgggattggt ctgttttcct gacacatgtg aaatgcactg gggaggtcac acctacctaa

310801
gagaaggaga aaaggatgct gggtgtcccc aaacaacaaa tgttcaagac ttggttttgt

310861
tgccttcttt atgcttagcc ttttttcttt tccctctctc tatctagcat gcataaatgt

310921
aaagttgaat gcbgggtgct gaattagatg attacagtga tgtacagtta tcagactagt

310981
ttttaatgaa atttttaatt ttttaaatca atactacatg tgtgcataat ttagagttcc

311041
atttagaatt tcataattct ataaggctta tcatgaaaaa cagcatcttc ttctgcctcc

311101
tacaccagtt ttgctctctt ctcctcccct gcactcaaat accctaagac aaacactttc

311161
aatttgttag ttgattttta gatatttatc tccaaattac ctaattttgt tgtaatttct

311221
tgacttttta gttttaagta ttatctctta aaattattaa ctacaatgga tataataatt

311281
ttaatagata atatttaaac gatttttata ctcttgcccc agtctttcta tgcattctac

311341
ctatgtagtt atattattat tttggttagg ccagtataca ttattatgga cacacagtct

311401
tcacagctaa gccaagtagt aaactatgat acttgtgcat actttaaaat tttctcagga

311461
ttcataattc ataatttctc tttttaaaca ttttcttatt tttatatatg tttcagtgat

311521
gcatttaatt tccaaatctc tgctatttat tgagttatac tctcaatata ttcagacata

311581
ttgggttatc tgtccatttc atttccttag agaaatcttt cccagaatct tctgcacttc

311641
tccaatttca actagtgtgt gtctgggata cagctgtcat cctttcattt ttcttcactg

311701
tcattcaaca ggatctctgt cactttatcc tgttttggat actgtgtttt ccattttccc

311761
caacttcctc tcttttggtc tgctcacatt ttgccagtaa gaaagggtat gtgagaggca

311821
aattttctga gaccatgcct atctgaaatt gttcttctct tactctccct tttgactgat

311881
agtttggggg tcaaaaatac tcatctaatt atattagaaa taatatccct tcaaaatagt

311941
attttttcag aggtttccca tgccttttag attccacaat tgctcttgag tagtttaaag

312001
ccattgtgat tcttagtctt tcttgagcaa cttgtatttt tgattatctg tttggttttc

312061
caatctggaa agttctaggg tctccttatc tgcatgttca gaatttcatg atggtgtatc

312121
ttgcatggat ctatttttat tccttgtgta ctcatcaatg gacttttgct ctttggttga

312181
agggaatttt cttgaattgt ttacaaattc tttccatcca ttttctgttt tttttttttt

312241
catgtagaat ttctaattta tttttcatcc ttaaattccc tttgtctctt tgctttacct

312301
atgaacattt ccttatcttt aaattttaac atttctcttg gccttttcac ttttgctatc

312361
ataattttag tttctgcaag ctgttttgtt ctttaattct tcttttttaa acagcatgct

312421
gtttttgttt aatggctgca atggcttgtt ttgtctttat gagaatatta ataactcttt

312481
ttgatgtttc tttgcctttg atagtctgtt ttctctaagc tgttttgttc ttctttctcc

312541
cctgcttggt aattcccctg ctttgtgacc ctcagctcat atttcagggt aggatgcaaa

312601
ggtgggtttc gaagctttaa gcacatggat ggggcttgtg ggcagatcct cattggggga

312661
ctctgcctgg gctgccgctg aacccccatg tcagtatttt taggcttctc ctcttaagct

312721
gatcagattc ctcagaaaaa ttacttccga actcctgccc agagagtaaa gatttgcctg

312781
gcaaatctgt agcacctgag tgggaaaaac aacacgggtg gggctcagct ttcaacctac

312841
aaatgctcac ttagccccct ctttttactg cggcactcct tgtggtcttc taacccagaa

312901
gcatctctgt tttactcttt ttagaaaaaa ttattccagt cttctgccag attaaaggta

312961
gtgggggttg gggagcaatt attcatttgt accaagtgaa gccgatctca gactctaact

313021
gctgctgttt cgttttttaa taacccccac ccctttgccc caccaagctt gactgcttct

313081
taacagctaa aacatcctct ttgtattggt tccttacttc cagaggtacc tgttgctgca

313141
aattactgaa cgtttcagag attttatgtg taaattatgt tgcttactgt ctttttcctc

313201
ccctggctta gcttttcagt ttgttagaat tgataagtca ttatcattaa tctgtctgct

313261
ttccagcttc taaaattttg tcattgatgt ctcttcccct attctccccc tccttgcagg

313321
tttatgcaac cttctccatc ttcctcccca accccctcaa aatttcttga ctgtcatgtt

313381
tgtgaaaggg tgaaagttca attcaatgta tttacctccg cagtttaggc aaacctttgt

313441
atttcctaca ctaggagaac aatggtttta tgtccatctt cactctgttc atcccacagt

313501
gcttacctga ggtattattt tgaaatagag tctgggatgg agtctacctt agtgagaatt

313561
tattagaatt gtttagtctc tgcagaagat gaggtggttg aagcacatac atcacatata

313621
ctagcagtgc ttttgtataa tttaatatta tcaaattagt acttaagaat ggaaaattct

313681
gacttataag atctaaattc taattaaggc ttattgttat ctttattgtt ttaaatgata

313741
atataatgct atagcatgct attcatctga tattttttcc ataatgtgta tggccaccca

313801
gtaaacacct actgaatatc tactgaaaaa tgaggaactc ttttgttgga aaaatataaa

313861
atattcatca cataagcaat aatgtataaa tgttacaaaa aagtagtaca ttcattctgc

313921
cttgtttaga atatgtgaag cctttgcaaa ctaagaaaca tggaaatatt ttgaacatta

313981
aaatggtaaa tattatggga aagtagagca catttggaca atacagattt ctggccacct

314041
cattcagaac cattaagcac actgaaagct acgtttttat ttgcctcctg ttcatcttct

314101
ctctctctct ccttgttttt tttttttttt tttttctgtt ttgtgaacag ctgcagctgc

314161
tggtcgccag taataagtat cctgagagcc cagaaaaggt acactttgcc ttgctgttta

314221
aaagtaatgc aatatgtgaa cgcccagaga acaagcactg tggaactgct attttcctgt

314281
tctacccttg atggattttc aaggtcatgc tggccaatta aggcatcatc agtcctacct

314341
gagcaacaag aatctaaact ttattccaag tcagaaactg tttctgcaga gccactctct

314401
cccctgctcc atttcgtgac tttttttttt tttttaacaa attgagttta gaagtgagtg

314461
taatccagca atacagttta ctggtttagt tggtgggtta attaaaaaaa atttgctcat

314521
atgaactttc attttatatg tttcttttgc c

Pejvakin (PJVK)

The PJVK gene encodes “pejvakin” (PJVK). PJVK is a member of the gasdermin family, and is required for the proper function of auditory pathway neurons. Mutations in PJVK may lead to non-syndromic sensorineural hearing loss. For example, a v.930_931del AC frameshift mutation in PJVK has been associated with deafness (Zhang et al., Acta Otolaryngol 135(3): 211-216, 2015).

The human PJVK gene is located on chromosome 2q231. It contains 8 exons encompassing ˜17 kilobases (kb) (NCBI Accession No. NG_012186.1). The full-length wildtype PJVK protein expressed from the human PJVK gene is 352 amino acids in length.

An exemplary human wildtype PJVK protein is or includes the sequence of SEQ ID NO: 51, SEQ ID NO: 53, SEQ ID NO: 55, SEQ ID NO: 57, SEQ ID NO: 59, or SEQ ID NO: 61. Non-limiting examples of nucleic acid encoding a wildtype PJVK protein are or include SEQ ID NO: 52, SEQ ID NO: 54, SEQ ID NO: 56, SEQ ID NO: 58, SEQ ID NO: 60 and SEQ ID NO: 62.

Human PJVK Protein Isoform 1 (NCBI Accession No. NP_001036167.1)

(SEQ ID NO: 51)

MFAAATKSFVKQVGDGGRLVPVPSLSEADKYQPLSLVVKKKRCFLFPRYKFTSTPFTLKDILLGDREISAG

ISSYQLLNYEDESDVSLYGRRGNHIVNDVGINVAGSDSIAVKASFGIVTKHEVEVSTLLKEITTRKINFDH

SLIRQSRSSRKAVLCVVMESIRTTRQCSLSVHAGIRGEAMRFHFMDEQNPKGRDKAIVFPAHTTIAFSVFE

LFIYLDGAFDLCVTSVSKGGFEREETATFALLYRLRNILFERNRRVMDVISRSQLYLDDLFSDYYDKPLSM

TDISLKEGTHIRVNLLNHNIPKGPCILCGMGNFKRETVYGCFQCSVDGQKYVRLHAVPCFDIWHKRMK

Human PJVK Isoform 1 cDNA

(SEQ ID NO: 52)

atgtttgctgctgctaccaagagctttgtcaagcaagttggagatggagggagattagttcctgttccaag

cctcagtgaagctgacaaatatcaacctctaagtctggtggtaaaaaagaagcgatgctttctgtttccta

gatataaatttacttcaacaccttttacactgaaagatattctcctaggagacagagaaatttcagctggt

atttcatcttatcaattactgaattatgaagatgaatcagatgtttcactctatggaaggcgaggtaacca

tattgtaaatgacgttgggattaacgttgctggatcagattccattgcagtgaaagottcatttggtatag

taaccaaacatgaagtggaagtatcaacattactcaaagaaattactacacgaaaaattaactttgaccac

agottgatacgtcagtcaaggagcagcagaaaggcagtattgtgtgtggtcatggagagcatccgaaccac

acgacagtgctcactgtctgtgcatgctggaattcgaggggaagcaatgoggtttcactttatggatgaac

agaatcccaagggaagggacaaagctattgttttcccagcacatacaaccatagotttcagtgtttttgaa

ctottcatatacctggatggtgcctttgacctttgtgtcacttcagtgtcaaaaggaggatttgaaaggga

agaaacggcaacatttgcactgctgtacaggttgagaaatatcctatttgaaagaaatagaagagtgatgg

atgtcatttctcgttcacagotttacttggatgatcttttttctgactactatgacaaacctctcagcatg

actgatatttcactcaaagaagggacccatatccgagttaacttacttaatcacaacattcccaaagggcc

ttgcatactctgtggaatggggaacttcaaaagggagacagtttatgggtgotttcagtgttctgttgatg

gtcagaagtatgtgagacttcatgcagttccttgttttgatatttggcacaagaggatgaaataa

Human PJIVK Protein Isoform 2 (NCBI Accession No. NP_001340704.1)

(SEQ ID NO: 53)

MAFAWDAAPLSFVKQVGDGGRLVPVPSLSEADKYQPLSLVVKKKRCFLFPRYKFTSTPFTLKDILLGDREI

SAGISSYQLLNYEDESDVSLYGRRGNHIVNDVGINVAGSDSIAVKASFGIVTKHEVEVSTLLKEITTRKIN

FDHSLIRQSRSSRKAVLCVVMESIRTTRQCSLSVHAGIRGEAMRFHFMDEQNPKGRDKAIVFPAHTTIAFS

VFELFIYLDGAFDLCVTSVSKGGFEREETATFALLYRLRNILFERNRRVMDVISRSQLYLDDLFSDYYDKP

LSMTDISLKEGTHIRVNLLNHNIPKGPCILCGMGNFKRETVYGCFQCSVDGQKYVRLHAVPCFDIWHKRMK

Human PJVK Isoform 2 cDNA

(SEQ ID NO: 54)

atggcgtttgcctgggatgcagcacctttgagotttgtcaagcaagttggagatggagggagattagttcc

tgttccaagcctcagtgaagctgacaaatatcaacctctaagtctggtggtaaaaaagaagcgatgctttc

tgtttcctagatataaatttacttcaacaccttttacactgaaagatattctcctaggagacagagaaatt

tcagctggtatttcatcttatcaattactgaattatgaagatgaatcagatgtttcactctatggaaggcg

aggtaaccatattgtaaatgacgttgggattaacgttgctggatcagattccattgcagtgaaagcttcat

ttggtatagtaaccaaacatgaagtggaagtatcaacattactcaaagaaattactacacgaaaaattaac

tttgaccacagottgatacgtcagtcaaggagcagcagaaaggcagtattgtgtgtggtcatggagagcat

ccgaaccacacgacagtgctcactgtctgtgcatgctggaattcgaggggaagcaatgcggtttcacttta

tggatgaacagaatcccaagggaagggacaaagctattgttttcccagcacatacaaccatagctttcagt

gtttttgaactcttcatatacctggatggtgcctttgacctttgtgtcacttcagtgtcaaaaggaggatt

tgaaagggaagaaacggcaacatttgcactgctgtacaggttgagaaatatcctatttgaaagaaatagaa

gagtgatggatgtcatttctcgttcacagctttacttggatgatcttttttctgactactatgacaaacct

ctcagcatgactgatatttcactcaaagaagggacccatatccgagttaacttacttaatcacaacattcc

caaagggccttgcatactctgtggaatggggaacttcaaaagggagacagtttatgggtgctttcagtgtt

ctgttgatggtcagaagtatgtgagacttcatgcagttccttgttttgatatttggcacaagaggatgaaa

taa

Human PJVK Protein Isoform 3 (NCBI Accession No. NP_001340705.1)

(SEQ ID NO: 55)

MYVYRLLSITVLMDILLEGLHSQYFTIYELRITPMAKHFSTQSFVKQVGDGGRLVPVPSLSEADKYQPLSL

VVKKKRCFLFPRYKFTSTPFTLKDILLGDREISAGISSYQLLNYEDESDVSLYGRRGNHIVNDVGINVAGS

DSIAVKASFGIVTKHEVEVSTLLKEITTRKINFDHSLIRQSRSSRKAVLCVVMESIRTTRQCSLSVHAGIR

GEAMRFHFMDEQNPKGRDKAIVFPAHTTIAFSVFELFIYLDGAFDRRVMDVISRSQLYLDDLFSDYYDKPL

SMTDISLKEGTHIRVNLLNHNIPKGPCILCGMGNFKRETVYGCFQCSVDGQKYVRLHAVPCFDIWHKRMK

Human PJVK Isoform 3 cDNA

(SEQ ID NO: 56)

atgtatgtatatagattactatccatcactgttttaatggatatcttattggaagggctacatagtcagta

tttcacaatatatgaactccgcataacacctatggcaaaacatttcagcactcagagotttgtcaagcaag

ttggagatggagggagattagttcctgttccaagcctcagtgaagctgacaaatatcaacctctaagtctg

gtggtaaaaaagaagcgatgotttctgtttcctagatataaatttacttcaacaccttttacactgaaaga

tattctcctaggagacagagaaatttcagctggtatttcatcttatcaattactgaattatgaagatgaat

cagatgtttcactctatggaaggcgaggtaaccatattgtaaatgacgttgggattaacgttgctggatca

gattccattgcagtgaaagottcatttggtatagtaaccaaacatgaagtggaagtatcaacattactcaa

agaaattactacacgaaaaattaactttgaccacagottgatacgtcagtcaaggagcagcagaaaggcag

tattgtgtgtggtcatggagagcatccgaaccacacgacagtgctcactgtctgtgcatgctggaattcga

ggggaagcaatgoggtttcactttatggatgaacagaatcccaagggaagggacaaagctattgttttccc

agcacatacaaccatagotttcagtgtttttgaactottcatatacctggatggtgcctttgatagaagag

tgatggatgtcatttctcgttcacagotttacttggatgatcttttttctgactactatgacaaacctctc

agcatgactgatatttcactcaaagaagggacccatatccgagttaacttacttaatcacaacattcccaa

agggccttgcatactctgtggaatggggaacttcaaaagggagacagtttatgggtgotttcagtgttctg

ttgatggtcagaagtatgtgagacttcatgcagttccttgttttgatatttggcacaagaggatgaaataa

Human PJVK Protein Isoform 4 (NCBI Accession No. NP_001340706.1)

(SEQ ID NO: 57)

MESIRTTRQCSLSVHAGIRGEAMRFHFMDEQNPKGRDKAIVFPAHTTIAFSVFELFIYLDGAFDLCVTSVS

KGGFEREETATFALLYRLRNILFERNRRVMDVISRSQLYLDDLFSDYYDKPLSMTDISLKEGTHIRVNLLN

HNIPKGPCILCGMGNFKRETVYGCFQCSVDGQKYVRLHAVPCFDIWHKRMK

Human PJVK Isoform 4 cDNA

(SEQ ID NO: 58)

atggagagcatccgaaccacacgacagtgctcactgtctgtgcatgctggaattcgaggggaagcaatgcg

gtttcactttatggatgaacagaatcccaagggaagggacaaagctattgttttcccagcacatacaacca

tagotttcagtgtttttgaactottcatatacctggatggtgcctttgacctttgtgtcacttcagtgtca

aaaggaggatttgaaagggaagaaacggcaacatttgcactgctgtacaggttgagaaatatcctatttga

aagaaatagaagagtgatggatgtcatttctcgttcacagotttacttggatgatcttttttctgactact

atgacaaacctctcagcatgactgatatttcactcaaagaagggacccatatccgagttaacttacttaat

cacaacattcccaaagggccttgcatactctgtggaatggggaacttcaaaagggagacagtttatgggtg

ctttcagtgttctgttgatggtcagaagtatgtgagacttcatgcagttccttgttttgatatttggcaca

agaggatgaaataa

Human PJVK Protein Isoform 5 (NCBI Accession No. NP_001340707.1)

(SEQ ID NO: 59)

MESIRTTRQCSLSVHAGIRGEAMRFHFMDEQNPKGRDKAIVFPAHTTIAFSVFELFIYLDGAFDLCVTSVS

KGGFEREETATFALLYRLRNILFERNRRVMDVISRSQLYLDDLFSDYYDKPLSMTDISLKEGTHIRVNLLN

HNIPKGPCILCGMGNFKRETVYGCFQCSVDGQKYVRLHAVPCFDIWHKRMK

Human PJVK Isoform 5 cDNA

(SEQ ID NO: 60)

atggagagcatccgaaccacacgacagtgctcactgtctgtgcatgctggaattcgaggggaagcaatgcg

gtttcactttatggatgaacagaatcccaagggaagggacaaagctattgttttcccagcacatacaacca

tagotttcagtgtttttgaactottcatatacctggatggtgcctttgacctttgtgtcacttcagtgtca

aaaggaggatttgaaagggaagaaacggcaacatttgcactgctgtacaggttgagaaatatcctatttga

aagaaatagaagagtgatggatgtcatttctcgttcacagotttacttggatgatcttttttctgactact

atgacaaacctctcagcatgactgatatttcactcaaagaagggacccatatccgagttaacttacttaat

cacaacattcccaaagggccttgcatactctgtggaatggggaacttcaaaagggagacagtttatgggtg

ctttcagtgttctgttgatggtcagaagtatgtgagacttcatgcagttccttgttttgatatttggcaca

agaggatgaaataa

Human PJVK Protein Isoform 6 (NCBI Accession No. NP_001356841.1)

(SEQ ID NO: 61)

MFAAATKSFVKQVGDGGRLVPVPSLSEADKYQPLSLVVKKKRCFLFPRYKFTSTPFTLKDILLGDREISAG

ISSYQLLNYEDESDVSLYGRRGNHIVNDVGINVAGSDSIAVKASFGIVTKHEVEVSTLLKEITTRKINFDH

SLIRQSRSSRKAVLCVVMESIRTTRQCSLSVHAGIRGEAMRFHFMDEQNPKGRDKAIVFPAHTTIAFSVFE

LFIYLDGAFDLCVTSVSKGGFEREETATFALLYRLRNILFERNRRVMDVISRSQLYLDDLFSDYYDKPLSM

TDISLKEGTHIRVNLLNHNIPKGPCILCGMGNFKRETVYGCFQCSVDGQKYVRLHAVPCFDIWHKRMK

Human PJVK Isoform 6 cDNA

(SEQ ID NO: 62)

atgtttgctgctgctaccaagagctttgtcaagcaagttggagatggagggagattagttcctgttccaag

cctcagtgaagctgacaaatatcaacctctaagtctggtggtaaaaaagaagcgatgctttctgtttccta

gatataaatttacttcaacaccttttacactgaaagatattctcctaggagacagagaaatttcagctggt

atttcatcttatcaattactgaattatgaagatgaatcagatgtttcactctatggaaggcgaggtaacca

tattgtaaatgacgttgggattaacgttgctggatcagattccattgcagtgaaagottcatttggtatag

taaccaaacatgaagtggaagtatcaacattactcaaagaaattactacacgaaaaattaactttgaccac

agottgatacgtcagtcaaggagcagcagaaaggcagtattgtgtgtggtcatggagagcatccgaaccac

acgacagtgctcactgtctgtgcatgctggaattcgaggggaagcaatgoggtttcactttatggatgaac

agaatcccaagggaagggacaaagctattgttttcccagcacatacaaccatagotttcagtgtttttgaa

ctottcatatacctggatggtgcctttgacctttgtgtcacttcagtgtcaaaaggaggatttgaaaggga

agaaacggcaacatttgcactgctgtacaggttgagaaatatcctatttgaaagaaatagaagagtgatgg

atgtcatttctcgttcacagotttacttggatgatcttttttctgactactatgacaaacctctcagcatg

actgatatttcactcaaagaagggacccatatccgagttaacttacttaatcacaacattcccaaagggcc

ttgcatactctgtggaatggggaacttcaaaagggagacagtttatgggtgotttcagtgttctgttgatg

gtcagaagtatgtgagacttcatgcagttccttgttttgatatttggcacaagaggatgaaataa

In some embodiments of any of the compositions described herein, the PJVK protein comprises a sequence that is at least 75% (e.g., at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%) identical to SEQ ID NO: 51.

A non-limiting example of a human wildtype PJVK genomic DNA sequence is SEQ ID NO: 63. The exons in SEQ ID NO: 63 are: nucleotide positions 5001-5334 (exon 1); nucleotide positions 6953-7185 (exon 2) and nucleotide positions 7897-8092 (exon 3); nucleotide positions 8281-9208 (exon 4); nucleotide positions 9575-9716 (exon 5); nucleotide positions 12075-12192 (exon 6); nucleotide positions 13913-14011 (exon 7); and nucleotide positions 14547-15131 (exon 8). The introns in SEQ ID NO: 63 are: nucleotide positions 1-5000 (intron 1); nucleotide positions 5335-6952 (intron 2); nucleotide positions 7186-7896 (intron 3); nucleotide positions 8093-8280 (intron 4); nucleotide positions 9209-9574 (intron 5); nucleotide positions 9717-12074 (intron 6); nucleotide positions 12193-13912 (intron 7); and nucleotide positions 14012-14546 (intron 8).

Human PJVK Gene Sequence (NCBI Reference Sequence: NG_012186.1)

(SEQ ID NO: 63)

1
tttcttgccg ggagagaggg attagaggga ttgtcoggcg tgggtctagg gtcgttgagg

61
cctaaagtta agcctttgtg gggaggacgg attgggggct gggtcacttt aagaaaaaga

121
ttctaaaatt acgaaggcag aattccaggg agtctccojg gcctggtcct gaagcttgag

181
accccggata tatacgctcc agggggctgc ggtgcgctct tcgggtcccc gagccctgtg

241
tttaggaaca cgoggggacg tccaaacacc cgctoctotc ccgccgggcg ggctcctttg

301
tcttctgggc tttcgtcgcg agatggaacg ctgggtcagt gcatcccagc aaaacacgtt

361
aggagtaaac gaaggccttt cojgggacct gggtagtojg ttgtaatggc gtttgcctgg

421
gatgcagcac ctttggtggg ccattagatg acgtgtcgct tctccagggg cttgctaggc

481
actagcagaa atgctcccct gtgcttactc ggtgttatgg aagattgctt gcacaatgct

541
attcgtacga aaggatatta ttaaaagtga tttatgggcg ggcgcggtgg ctcacgcctg

601
taatcccagc actttaggag gccgaggctg gcggatcgcc tgaagtaagc agttcgagac

661
cagcctggcc aacatggtga aaccctgtct ctactaaaaa tacaaaaatt agccgggcgt

721
ggtggcatgc gcctgtaatc ccagctactc gggaggctaa agcaggagaa tcgcttgaac

781
cojggaggca aabittgcag tgagccgaga tcgcgccact gcactccagc ctgggcgaca

841
gagtcagact ccctctcaaa aaaaaaaaaa aaaaaaaaag cgatttgttg ttttgttagc

901
atgtaagccc tggatgcttg aaacaagtga aagatgttca gaatctaatc aaattatatc

961
atctgatgct ttaattagag cctattctct cttcctctcc gtctatatat gtatgtatat

1021
agattactat ccatcactgt tttaatggat atcttattgg aagggctaca tagtcagtat

1081
ttcacaatat atgaactccg cataacacct atggcaaaac atttcagcac tcaggtaaaa

1141
ttcatttttt gccacaaaat tacttaaaaa caggccagaa ctttatatag ctcttgttaa

1201
aggttaagta gcbjggataa taatgaaaca aaaagatgca gcaggactcc atttcaaaga

1261
gagagagtct gtgtgcccaa cttcagagta agaaaccact aggtaatagt ttatatagtt

1321
acttatatgt aatgtggctt tattttttaa ataaagattt gcatataatt gtttatatct

1381
gtgaatttat atttaatatt aaacacagtt ttgtaagcat ataagatgga aaatgaatga

1441
aatgctcaat caatgagctg tatgccatga ggattcaaaa cagcactttg gtgttgccaa

1501
aattccggtg gtggacttgt gaaggaattc cctttggact aggtccactg tagattgtat

1561
cojggactat cgttagtgcc taaattgcat tgcttcccac agcactatat gcttccctta

1621
aaattggccc attgccagtg gcaaatcact atctactgtg atccttatca tagacattgg

1681
tcatattttt acgttattag ttttctgtgt atattttagt gctatagcct gccattccaa

1741
gttaaacatg ctcttagcat atcattttac accgttgatc tataattcat tacctgagca

1801
catgagcaga ggcagggaat tatacagtgg taaactactt ggtgaaacca tgctttgtat

1861
ttttaagatg tataattata tttaaaaaca agcaatgctt aattttgtgc ctgattttcc

1921
tctttaaaaa tggatttatc tgggggttgc agttgatgac gttttgattt taatatgttt

1981
gctgctgcta ccaagagctt tgtcaagcaa gttggagatg gagggagatt agttcctgtt

2041
ccaagcctca gtgaagctga caaatatcaa cctctaagtc tggtggtaaa aaagaagcga

2101
tgctttctgt ttcctagata taaatttact tcaacacctt ttacactgaa agatattctc

2161
ctaggagaca gagaaatttc agctggtaag tttaaatgtt tgggagtgcc aactcattca

2221
tctgtattat tggcaaccta aacataggtc atatatgcta cttatgttag taatacacat

2281
tttcaatgat taaagcaact tttattatga bittagtgta ataacattat taagattaac

2341
aatgccaaaa gtttgtataa tatcaaatct cttattggtc aaataatttt caaatctatc

2401
aattatttta taaattgttt taaccaaatc aacttagaat atgacatatt tcttcatcta

2461
taaaatggga tattatttgg gcttacctat gttacatggt caaatgagat gaaaataatt

2521
tgtatttatt ttttacaatt caattattac aattggtaaa ctgaaatgta ttgaagggta

2581
ggttatataa taagctgata ttttgatgag ttactactta taaacgctta ttttttcttt

2641
taattgcccg gtggatcttg atgcttaaga agttctgttg gctgaataga aaatttgagt

2701
tccttttaag aattctggct atgtgtttct ttttgttgta agattaattg aattactact

2761
ttaagtcttg gtgagtcatg ttgcctttct ctaacatttg ggtatttgag tcttcaattg

2821
ttaatttaac atgttactat atataatcta cataagataa agatgtttaa aaaatactga

2881
gtttcttctt ataaaggtat ttcatcttat caattactga attatgaaga tgaatcagat

2941
gtttcactct atggaaggcg aggtaaccat attgtaaatg acgttgggat taacgttgct

3001
ggatcagatt ccattgcagt gaaagcttca tttggtatag taaccaaaca tgaagtggaa

3061
gtatcaacat tactcaaaga aattactaca cggtcagtat aataatccta atatatttca

3121
gtgttttcat taaatacttt aggtatataa acttcattac aaagaatgct taaaacattg

3181
aggttgtatt ttactagtgt aatttgctag atatgtttga aatacattgg tagtatatcc

3241
aaactttgaa taaggataga tatcaaaaat cacttggctg aagtcagaga cctcagggcc

3301
ccagatcaag gagctaactg atgaagaggc agagaggctg cagctagaga ttgaccagaa

3361
ataggatgca gagaatcatg aggcccagat caagaatggc agccttgact ccccagggaa

3421
gcagaagact gaggaagatg aggaggagga agatgagaag gacaaaggaa aactgaagcc

3481
caacctaggc aacagggcag acctgcctga ttaccgctgg accaagaccc tgtcggagct

3541
ggacctggcg gtccctttct gtgtggactt ccagctgaaa gggaaggacg tggtggtggc

3601
atccaacggc ggcacctcca ggtggggctc aaggggcagc cagcgatcat cgatggggag

3661
ctctacaacg aagtgaaggc ggaggagagc tcgtggctca ttgaggacgg caaggtggtg

3721
actgtgcatc tggagaagat caagaagatg gagtggtgga gccgcttggt gtccagtgac

3781
cctgagatca ataccaagaa gattaaccct gagaattcca agctgtcaga cctggacagt

3841
gagactcaca tcatggtgga aaagacaatc tatgaccagt aacagaagtc catggggctg

3901
ccaacctcag acgaacagaa gaaacaggag attctgaaga agttcatgga tcagcatccg

3961
gagatggatt tttccaaggc taaattcaac tagcccctgt ttttccctcc ctgaactctt

4021
ggggctgagc tgcaaccacc caactttctt tcccactctt ctctgggact tgtgggcctc

4081
agggcttggg gcaggcatgg gactggccca ggcacacagg tcccagggca tcaggagaaa

4141
ggctggggct tggggtcttg tcctccccag ttggcctact gttacacatt aaaatgattt

4201
gcccagctaa aaaaaaaaaa aaaccacttg gcttaaacaa aacttttaat tgttccacaa

4261
aattactttg gctctacaca catttgctta attattagat ttaaataata cagcaatctg

4321
tctgcaacaa atagagtccc cttcaacaga ctttcaacag acagagtgaa acattctgca

4381
taagcatgtt ttaagaaaat agagaggaga gacaaattat tacatttctt ttgggtgtat

4441
tttctgacta ttaggattgc cttgatttac tattaggtga actatgaatg aataacacat

4501
gatagcaaaa aatgtatttg attatgtgta attagatgtt atagagtctt gtgaatgtat

4561
cttctttatt ttagaaaaat taactttgac cacagcttga tacgtcagtc aaggagcagc

4621
agaaaggcag tattgtgtgt ggtcatggag agcatccgaa ccacacgaca gtgctcactg

4681
tctgtgcatg ctggaattcg aggggaagca atgcgggtaa accacacttg ttgggttctc

4741
ttactaacta aagtgttgcc atgggaattt ttttaagtat tgaatttcta gtcaggcttg

4801
tgtattttgt gaaatgttct gatgaaagag ctgcagttgt ataggatttt gcacagcaat

4861
gtctgttcta gaatatgaaa aaaaaaaaca aatcttggga ttctaaacat gtgtaatata

4921
atgcaaaaac agtaatcctt gtgaaattac gtgcatactg gagtccctca agttactatt

4981
taagtgttgt tttaagaata aaaattgagt gagttgaatt gattttattt ttaagtgata

5041
cagtttttga ctgggcacag tggctcacgc ctgtaatcct agcattttgg gaggccgagg

5101
tgggcggatc acttgcagtc aggagttgga gatcaagttg ggcaacacag agaaacccca

5161
tctctactga aaatacaaaa attagccagg tgtggtggta cacccctgta atcccaagcc

5221
actcaggaag ctgaggcaca agaatcactt gaacctggga ggtggaggtt gcagtgagcc

5281
gagattgtgc cattgcactc taacctgggt ggcagagtga gactccgtct caaaaaaaca

5341
aaacaaaaca aaaaccccaa ccaaaaaaaa aatgtgtaac ataatgcaaa aacagtaatc

5401
cttgtgaaat tacatgcata ctggagtccc tcatattact atttaagtgc tgttttaaga

5461
ataaaaattg agtgcttaag ttgaattgat ttaagtgata gagtttttac actttgaatt

5521
ttttaaagct gaatttatag attttttttt tgagacggag tctcgctctg tccccgaggc

5581
tggagtgcag tggcgcgatc ttggctcact gcaaactccg cctccojggt tcatgccatt

5641
cttctgcctc agcctcccga gtagcbjgga ctacaggcac ctgccaccac gcccggcagt

5701
gttatccagg atggtttcga tctcctgacc tcgtgatccg ctagcctojg cctcccaaaa

5761
tgctgggatt acaggtgtga gccaccgcgc ctggcctgaa tttatatttt tatattcaaa

5821
tagtttttca aagttaatat tatcaatggc catacatgct ttattcaagg ttagttaaat

5881
cctttaaaaa atattagcgg caaggtgcag tggatcatgc ctgtaatccc agtgcttagg

5941
aagactgaga taggaagaca gcttgggacc aggagttcaa gaccaacttg agcaaaataa

6001
tgagaccttg tctctacaaa aaataaaaga attagctggt tgtggtggca catgcctata

6061
gtcccagcta ctcggaaggc tgaggcaggg ggctgcctgc ggggtttggg tcattgtctt

6121
ttagaatttg ggaggctttg aaaagccgtg cttttgtgct ggggaagatg tagcagtctc

6181
ttctccaaac cacccatttg ccttcggact tctctggggc cagcagccat ccaactaggg

6241
gccojgggcc acgggctcag ctgacgacca tgggcttcgc gtccaaccag cagtttgcag

6301
gttcgagctc aggacttggc ggggacacct taggatgcag gagtggccag gagttcaagg

6361
ttacagtagg ctatgattgt gccactgctc tccagcctgg gtgacagaga gagaccctgt

6421
ctctgaaaaa aaaattggaa aagtatctgt gtttaatttt cagctcaatt atgatattgt

6481
ttatctttgt cattcagtga cacctaataa tgacttgatt ggattaaaac caattgttag

6541
aaagataggg ttcaaggata atcttttcaa gtctttgcaa ataaaagtta ttttcgcata

6601
ttcagctgcc tgtcaaattc tgattaacat tggatcattt ttgaggcaca aactgaaaca

6661
tttacttgat tgttagcgat tgctttagaa agctactaaa agctctggag ggctttggaa

6721
tggtagacag gctaggctga aaactttaac tctggcactg ctttctaaga tttcctgtta

6781
aaaaaaaaaa aaaggcttct gctccagagc attatggttg tggtagcact aatcatgggc

6841
tgtaatacca aagtaagtga aaagtgcaga ggtatttcct aatatagacc aggagtttct

6901
gttggaccaa ttggatctct gctataaaaa atggtttaat tcaagcagaa taatccttta

6961
cttgggaatt ttttgttttg tttttggtag gattatagga aatgtttcat ttctccaaaa

7021
agctatcctt acatgttatg atccttaatt atgttattta tttattcaat atagtttcac

7081
tttatggatg aacagaatcc caagggaagg gacaaagcta ttgttttocc agcacataca

7141
accatagctt tcagtgtttt tgaactcttc atatacctgg atggtgcctt tggtgagtta

7201
agggtctgca tgaaatacaa atgattatat ttttaaggag cattcattag ggcatgtgct

7261
ctctctctct cttttctctc atttctcgtg tctaacaatt atagaagatg ctctcagcac

7321
tgtcaatctt atgctttggc aaaatagctg agaaagaccc tccgttcgct gcttccccat

7381
tccacttttc tgcttcttgg tgaaggttgt aaactctcca ctaccccatt taaaattata

7441
aataagagct aaaatgccat ctactgacaa agtattcctt agcttacatg gggagataat

7501
aaatgacctt cttataggta gtttttgatg gtggcaaaca gaggagtagg tagatagtag

7561
gatgcctgaa gtgttaggat gcccaaacca gggcctctaa agacagcttt tcttacttca

7621
gttttactta tcatagaccc agcttcccct tgcactcttc ctaaaaaata actttaaaaa

7681
gtgaaaatac ttcctccaaa attgtcacct tgtataatac ctaagtgcag ctcactttag

7741
gtctctacat ttcacaggtc tttaaggtct gttggccaac tggaacaagt ccaggtgtag

7801
cccaagggat caggaaaggc agcccctagc catggtaatt tacaaatgtt tttagacctg

7861
ttcttgttca tttctgcaat tttgtaggag gagggaatag ggagtccaga aacaaaacaa

7921
aactacatgt taagtaaatt gtctttttaa aaaatatttt taatttttgt ggctatatag

7981
tagattatat atatatttat gtatgggata catgaggtat tttgatacgg gcatacagtg

8041
cataataatc acatcatgga aaatggggta tccatcccct caagcattta tcctttgtgt

8101
tacaaacaat ccaattatac tcttttagtt atttaaaaat gtacaaattc tcagtctaag

8161
atggagaaaa aactgtacaa ttacattatt ttgactgtag tcaccctatt atgcttccaa

8221
atactaggtc ttattaagta aattctaatt ggataacttt aggtttttac agttttattg

8281
atggttggga ggaatgtaaa tggactgata tatccacaag aatttaaaat atatatataa

8341
tttggacttc cacttctagg aatttatcct acagatatat ttacacatat atgaaatgat

8401
atgagtgcaa gtatattcag tcctcaataa caagagattg gaaacaacat taaggagact

8461
aaataatggt gcatccttgc aagagaatac tatgaagcca ataagaatat aatactttta

8521
atagatattt ttcaagagct gagtataata tgtaactatt tgggcataaa taattttata

8581
cacatacatg tatatatgca tctttcttta tgcttataaa atatatggag tatttctgga

8641
agcaaacata agaaacttaa accacgggtg cccctaagcc cctgaggtag aagactgtgg

8701
ctggatacag ggtgggccag agacctattt gtcactgtat ctcctttctg tatgaatttt

8761
gtaccatgtg aatgttacct tttccaaaag tatgtaaaag tcaactttta aaaacaatac

8821
aatgaatgat ttgtactaga attcatcacc ccatcaaaca ataaaatatg aattattcaa

8881
gttataacat cttctaacaa ttttttttgt agacctttgt gtcacttcag tgtcaaaagg

8941
aggatttgaa agggaagaaa cggcaacatt tgcactgctg tacaggttga gaaatatcct

9001
atttgaaaga agtatgttta ttgaagagta ctgtgaatgt cttttttttt tctttcctgg

9061
cttaacacat gaggttttct attcagtaat ctcatctgtt aaggaaaaat ttaaatttaa

9121
aagcctggct ggtatggtgg ctcatgccta taatcccagc actttgggag gccagggcag

9181
gcagattgct agcactcaga agtttgaaac acttgggcaa tgtgagaaaa ccccatctgt

9241
acaaagaata caaaagaaaa aaaattagtt ggttgcagtg gtgtgcacct gtagtcccag

9301
ctacttgaga ggctgaggta ggaggatcac ttgagcgtgg gaggcggagg ttgtagtaag

9361
tggagattgt gccactgccc tccagottgg gtgacagagc cagaccctgt ctcaaaaaaa

9421
aaaaaaaaaa aaaaaaagcc aaattatttc atgactagtg gattcacata tttattaatg

9481
ctgtttgcat tatgtatttt tcattttcac ttctaacaca tttcttttct gtttttgtcc

9541
ttttagatag aagagtgatg gatgtcattt ctcgttcaca gctttacttg gatgatcttt

9601
tttctgacta ctatgacaaa cctctcagca tgactgatat ttcactcaaa gaagggaccc

9661
atatccgagt taacttactt aatcacaaca ttcccaaagg gccttgcata ctctgtggaa

9721
tggggaactt caaaagggag acagtttatg ggtgctttca gtgttctgtt gatggtcaga

9781
agtatgtgag acttcatgca gttccttgtt ttgatatttg gcacaagagg atgaaataaa

9841
atgaaaaatg aatacaccgt gttggtgttt taggtgcagt tgtgccacaa accttcccta

9901
aattatctag gtttgctttg atgaattaaa ttaaaatgag aaaagcaaaa agaaattaac

9961
ctgtctgggt atcatattcc ctatctataa agtagcaatt ataacagtag tgtctatttc

10021
ttaagttgtc atgaaaatta ataacattgt ttatatcaaa aaagatttac atataaaatt

10081
cagagattat gaatcatgcc agtcacttta gaatcatttt tgggatgtag t

Heat Shock Protein Family A (Hsp70) member 1A (HSPA1A)

The HSPA1A gene encodes “heat shock protein family A member 1A” (HSPA1A). The human HSPA1A gene is located on chromosome 6p21.33. It contains 1 exon, encompassing ˜2400 bp (NCBI Accession No. NC 000006.12). HSPA1A encodes a 70 kDa heat shock protein, which stabilizes proteins against protein aggregation and is involved in protein folding.

Exemplary wildtype HSPA1A protein sequences are or include SEQ ID NO: 64, SEQ ID NO: 66, SEQ ID NO: 68, SEQ ID NO: 69, SEQ ID NO: 70, and SEQ ID NO: 93. Exemplary DNA sequences that encode a NDP protein are shown below.

Human Mature HSPA1A Protein (NCBI Accession No. NP_005336.3)

(SEQ ID NO: 64)

MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAK

RLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNA

VITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTID

DGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEI

DSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFN

GRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQ

IFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGK

ANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKK

KVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEE

VD

Human Mature HSPA1A cDNA

(SEQ ID NO: 65)

atggccaaagccgcggcgatcggcatcgacctgggcaccacctactcctgcgtgggggtgttccaacacgg

caaggtggagatcatcgccaacgaccagggcaaccgcaccaccoccagctacgtggccttcacggacaccg

agoggctcatcggggatgcggccaagaaccaggtggcgctgaacccgcagaacaccgtgtttgacgcgaag

cggctgatcggccgcaagttcggcgaccoggtggtgcagtoggacatgaagcactggcctttccaggtgat

caacgacggagacaagcccaaggtgcaggtgagctacaagggggagaccaaggcattctaccccgaggaga

tctcgtccatggtgctgaccaagatgaaggagatcgccgaggcgtacctgggctaccoggtgaccaacgcg

gtgatcaccgtgccggcctacttcaacgactcgcagcgccaggccaccaaggatgogggtgtgatcgcggg

gctcaacgtgctgoggatcatcaacgagcccacggccgccgccatcgcctacggcctggacagaacgggca

agggggagcgcaacgtgctcatctttgacctgggcgggggcaccttcgacgtgtccatcctgacgatcgac

gacggcatcttcgaggtgaaggccacggccggggacacccacctgggtggggaggactttgacaacaggct

ggtgaaccacttcgtggaggagttcaagagaaaacacaagaaggacatcagccagaacaagcgagccgtga

ggcggctgcgcaccgcctgcgagagggccaagaggaccctgtcgtccagcacccaggccagcctggagatc

gactocctgtttgagggcatcgacttctacacgtccatcaccagggcgaggttcgaggagctgtgctccga

cctgttccgaagcaccctggagcccgtggagaaggctctgcgcgacgccaagctggacaaggcccagattc

acgacctggtoctggtogggggctccacccgcatccccaaggtgcagaagctgctgcaggacttcttcaac

gggcgcgacctgaacaagagcatcaaccccgacgaggctgtggcctacggggcggcggtgcaggcggccat

cctgatgggggacaagtccgagaacgtgcaggacctgctgctgctggacgtggctoccctgtcgctggggc

tggagacggccggaggcgtgatgactgccctgatcaagcgcaactccaccatccccaccaagcagacgcag

atcttcaccacctactccgacaaccaaccoggggtgctgatccaggtgtacgagggcgagagggccatgac

gaaagacaacaatctgttggggcgcttcgagctgagoggcatccctccggcccccaggggcgtgccccaga

tcgaggtgaccttcgacatcgatgccaacggcatcctgaacgtcacggccacggacaagagcaccggcaag

gccaacaagatcaccatcaccaacgacaagggccgcctgagcaaggaggagatcgagcgcatggtgcagga

ggcggagaagtacaaagoggaggacgaggtgcagcgcgagagggtgtcagccaagaacgccctggagtcct

acgccttcaacatgaagagcgccgtggaggatgaggggctcaagggcaagatcagcgaggcggacaagaag

aaggttctggacaagtgtcaagaggtcatctcgtggctggacgccaacaccttggccgagaaggacgagtt

tgagcacaagaggaaggagctggagcaggtgtgtaaccccatcatcagoggactgtaccagggtgccggtg

gtccogggcctgggggcttcggggctcagggtcccaagggagggtctgggtcaggccccaccattgaggag

gtggattag

Human Mature HSPA1A cDNA

(SEQ ID NO: 94)

atgtaccggatgcagctgctgagctgtatcgccctgtctctggccctggtcaccaattctgccaaagccgc

ggcgatcggcatcgacctgggcaccacctactcctgcgtgggggtgttccaacacggcaaggtggagatca

tcgccaacgaccagggcaaccgcaccaccoccagctacgtggccttcacggacaccgagcggctcatcggg

gatgoggccaagaaccaggtggcgctgaacccgcagaacaccgtgtttgacgcgaagoggctgatcggccg

caagttcggcgacccggtggtgcagtcggacatgaagcactggcctttccaggtgatcaacgacggagaca

agcccaaggtgcaggtgagctacaagggggagaccaaggcattctaccccgaggagatctcgtccatggtg

ctgaccaagatgaaggagatcgccgaggcgtacctgggctacccggtgaccaacgcggtgatcaccgtgcc

ggcctacttcaacgactcgcagcgccaggccaccaaggatgcgggtgtgatcgcggggctcaacgtgctgc

ggatcatcaacgagcccacggccgccgccatcgcctacggcctggacagaacgggcaagggggagcgcaac

gtgctcatctttgacctgggcgggggcaccttcgacgtgtccatcctgacgatcgacgacggcatcttcga

ggtgaaggccacggccggggacacccacctgggtggggaggactttgacaacaggctggtgaaccacttcg

tggaggagttcaagagaaaacacaagaaggacatcagccagaacaagcgagccgtgaggcggctgcgcacc

gcctgcgagagggccaagaggaccctgtcgtccagcacccaggccagcctggagatcgactccctgtttga

gggcatcgacttctacacgtccatcaccagggcgaggttcgaggagctgtgctccgacctgttccgaagca

ccctggagcccgtggagaaggctctgcgcgacgccaagctggacaaggcccagattcacgacctggtcctg

gtcgggggctccacccgcatccccaaggtgcagaagctgctgcaggacttcttcaacgggcgcgacctgaa

caagagcatcaaccccgacgaggctgtggcctacggggcggcggtgcaggcggccatcctgatgggggaca

agtccgagaacgtgcaggacctgctgctgctggacgtggctcccctgtcgctggggctggagacggccgga

ggcgtgatgactgccctgatcaagcgcaactccaccatccccaccaagcagacgcagatcttcaccaccta

ctccgacaaccaacccggggtgctgatccaggtgtacgagggcgagagggccatgacgaaagacaacaatc

tgttggggcgcttcgagctgagcggcatccctccggcccccaggggcgtgccccagatcgaggtgaccttc

gacatcgatgccaacggcatcctgaacgtcacggccacggacaagagcaccggcaaggccaacaagatcac

catcaccaacgacaagggccgcctgagcaaggaggagatcgagcgcatggtgcaggaggcggagaagtaca

aagcggaggacgaggtgcagcgcgagagggtgtcagccaagaacgccctggagtcctacgccttcaacatg

aagagcgccgtggaggatgaggggctcaagggcaagatcagcgaggcggacaagaagaaggttctggacaa

gtgtcaagaggtcatctcgtggctggacgccaacaccttggccgagaaggacgagtttgagcacaagagga

aggagctggagcaggtgtgtaaccccatcatcagcggactgtaccagggtgccggtggtcccgggcctggg

ggcttcggggctcagggtcccaagggagggtctgggtcaggccccaccattgaggaggtggattaa

In some embodiments of any of the compositions described herein, the HSPA1A protein comprises a sequence that is at least 75% (e.g., at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%) identical to SEQ ID NO: 64.

Mouse Mature HSPA1A Protein (NCBI Accession No. NP_034609.2)

(SEQ ID NO: 66)

MAKNTAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAK

RLIGRKFGDAVVQSDMKHWPFQVVNDGDKPKVQVNYKGESRSFFPEEISSMVLTKMKEIAEAYLGHPVTNA

VITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTID

DGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEI

DSLFEGIDFYTSITRARFEELCSDLFRGTLEPVEKALRDAKMDKAQIHDLVLVGGSTRIPKVQKLLQDFFN

GRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQ

TFTTYSDNQPGVLIQVYEGERAMTRDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGK

ANKITITNDKGRLSKEEIERMVQEAERYKAEDEVQRDRVAAKNALESYAFNMKSAVEDEGLKGKLSEADKK

KVLDKCQEVISWLDSNTLADKEEFVHKREELERVCSPIISGLYQGAGAPGAGGFGAQAPKGASGSGPTIEE

VD

Mouse Mature HSPA1A cDNA

(SEQ ID NO: 67)

atggccaag aacacggcga tcggcatcga cctgggcacc acctactcgt gcgtgggcgt

gttccagcac ggcaaggtgg agatcatcgc caacgaccag ggcaaccgca cgacccccag

ctacgtggcc ttcaccgaca ccgagcgcct catcggagac gccgccaaga accaggtggc

gctgaacccg cagaacaccg tgttcgacgc gaagcggctg atcggccgca agttcggcga

tgcggtggtg cagtccgaca tgaagcactg gccottccag gtggtgaacg acggcgacaa

goccaaggtg caggtgaact acaagggcga gagccggtog ttottccogg aggagatctc

gtccatggtg ctgacgaaga tgaaggagat cgctgaggcg tacctgggcc acccggtgac

caacgcggtg atcacggtgc ccgcctactt caacgactct cagojgcagg ccaccaagga

cgcgggcgtg atcgccggtc taaacgtgct gcggatcatc aacgagccca cggcggccgc

catcgcctac gggctggacc ggaccggcaa gggcgagcgc aacgtgctca tcttcgacct

ggggggcggc acgttcgacg tgtccatcct gacgatcgac gacggcatct tcgaggtgaa

ggccacggcg ggcgacacgc acctgggagg ggaggacttc gacaaccggc tggtgagcca

cttcgtggag gagttcaaga ggaagcacaa gaaggacatc agccagaaca agcgcgcggt

gojgcggctg cgcactgcgt gtgagagggc caagaggacg ctgtcgtcca gcacccaggc

cagcctggag atcgactctc tgttcgaggg catcgacttc tacacatcca tcacgcgggc

gog-gttcga gagctgtgct cagacctgtt ccgcggcacg ctggagcccg tggagaaggc

cctgcgcgac gccaagatgg acaaggcgca gatccacgac ctggtgctgg tgggcggctc

gacgcgcatc cccaaggtgc agaagctgct gcaggacttc ttcaacgggc gcgacctgaa

caagagcatc aaccoggacg aggcggtggc ctacggggcg goggtgcagg cggccatcct

gatgggggac aagtojgaga acgtgcagga cctgctgctg ctggacgtgg cgccgctgtc

gctgggcctg gagactgcgg gojgcgtgat gacggcgctc atcaagcgca actccaccat

ccccaccaag cagacgcaga ccttcaccac ctactcggac aaccagcccg gggtgctgat

ccaggtgtac gagggcgaga gggccatgac gcgcgacaac aacctgctgg ggcgcttcga

actgagojgc atcccgccgg cgcccagggg cgtgccacag atcgaggtga ccttcgacat

cgacgccaac ggcatcctga acgtcacggc caccgacaag agcaccggca aggccaacaa

gatcaccatc accaacgaca agggccgcct gagcaaggag gagatcgagc gcatggtgca

ggaggccgag cgctacaagg ccgaggacga ggtgcagcgc gacagggtgg ccgccaagaa

cgcgctcgaa tcctatgcct tcaacatgaa gagcgccgtg gaggacgagg gtctcaaggg

caagctcagc gaggctgaca agaagaaggt gctggacaag tgccaggagg tcatctcctg

gctggactcc aacacgctgg ccgacaagga ggagttcgtg cacaagojgg aggagctgga

gojggtgtgc agccccatca tcagtgggct gtaccagggt gojggtgctc ctggggctgg

gggcttoggg gcccaggcgc ccaagggagc ctctggctca ggacccacca tcgaggaggt

ggattaga

Rhesus Monkey Mature HSPA1A Protein (NCBI Accession No. XP_014991489.2)

(SEQ ID NO: 68)

MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAK

RLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNA

VITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTEDVSILTID

DGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEI

DSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFN

GRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQ

IFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGK

ANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKK

KVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEE

VD

Rat Mature HSPA1A Protein (NCBI Accession No. NP_114177.2)

(SEQ ID NO: 69)

MAKKTAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAK

RLIGRKFGDPVVQSDMKHWPFQVVNDGDKPKVQVNYKGENRSFYPEEISSMVLTKMKEIAEAYLGHPVTNA

VITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTID

DGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEI

DSLFEGIDFYTSITRARFEELCSDLFRGTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFN

GRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQ

TFTTYSDNQPGVLIQVYEGERAMTRDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGK

ANKITITNDKGRLSKEEIERMVQEAERYKAEDEVQRERVAAKNALESYAFNMKSAVEDEGLKGKISEADKK

KVLDKCQEVISWLDSNTLAEKEEFVHKREELERVCNPIISGLYQGAGAPGAGGFGAQAPKGGSGSGPTIEE

VD

Cattle HSPA1A Protein (NCBI Accession No. NP_976067.3)

(SEQ ID NO: 70)

MAKNMAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAK

RLIGRKFGDPVVQSDMKHWPFRVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGHPVTNA

VITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTID

DGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEI

DSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFN

GRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQ

IFTTYSDNQPGVLIQVYEGERAMTRDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGK

ANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKK

KVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISRLYQGAGGPGAGGFGAQGPKGGSGSGPTIEE

VD

Human Mature HSPA1A Protein

(SEQ ID NO: 93)

AKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKR

LIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNAV

ITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDD

GIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEID

SLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNG

RDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQI

FTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKA

NKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKK

VLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEV

D

A non-limiting example of a human wildtype NDP genomic DNA sequence is SEQ ID NO:71.

Human HSPA1A Gene Sequence(NCBI Reference Sequence NC_000006.12)

(SEQ ID NO: 71)

1
aacggctagc ctgaggagct gctgcgacag tccactacct ttttcgagag tgactcccgt
61

tgtcccaagg cttcccagag cgaacctgtg cggctgcagg caccggcgcg tcgagtttcc
121

ggcgtccgga aggaccgagc tcttctcgcg gatccagtgt tccgtttcca gcccccaatc
181

tcagagcgga gccgacagag agcagggaac cggcatggcc aaagccgcgg cgatcggcat
241

cgacctgggc accacctact cctgcgtggg ggtgttccaa cacggcaagg tggagatcat
301

cgccaacgac cagggcaacc gcaccacccc cagctacgtg gccttcacgg acaccgagcg
361

gctcatcggg gatgcggcca agaaccaggt ggcgctgaac ccgcagaaca ccgtgtttga
421

cgcgaagcgg ctgattggcc gcaagttcgg cgacccggtg gtgcagtcgg acatgaagca
481

ctggcctttc caggtgatca acgacggaga caagcccaag gtgcaggtga gctacaaggg
541

ggagaccaag gcattctacc ccgaggagat ctcgtccatg gtgctgacca agatgaagga
601

gatcgccgag gcgtacctgg gctaccoggt gaccaacgcg gtgatcaccg tgccggccta
661

cttcaacgac tcgcagcgcc aggccaccaa ggatgcgggt gtgatcgcgg ggctcaacgt
721

gctgcggatc atcaacgagc ccacggccgc cgccatcgcc tacggcctgg acagaacggg
781

caagggggag cgcaacgtgc tcatctttga cctgggcggg ggcaccttcg acgtgtccat
841

cctgacgatc gacgacggca tcttcgaggt gaaggccacg gccggggaca cccacctggg
901

tggggaggac tttgacaaca ggctggtgaa ccacttcgtg gaggagttca agagaaaaca
961

caagaaggac atcagccaga acaagcgagc cgtgaggcgg ctgcgcaccg cctgcgagag
1021

ggccaagagg accctgtcgt ccagcaccca ggccagcctg gagatcgact ccctgtttga
1081

gggcatcgac ttctacacgt ccatcaccag ggcgaggttc gaggagctgt gctccgacct
1141

gttccgaagc accctggagc ccgtggagaa ggctctgcgc gacgccaagc tggacaaggc
1201

ccagattcac gacctggtcc tggtoggggg ctccacccgc atccccaagg tgcagaagct
1261

gctgcaggac ttcttcaacg ggcgcgacct gaacaagagc atcaaccccg acgaggctgt
1321

ggcctacggg gojgcggtgc aggcggccat cctgatgggg gacaagtccg agaacgtgca
1381

ggacctgctg ctgctggacg tggctcccct gtcgcbgggg ctggagacgg ccggaggcgt
1441

gatgactgcc ctgatcaagc gcaactccac catccccacc aagcagacgc agatcttcac
1501

cacctactcc gacaaccaac ccggggtgct gatccaggtg tacgagggcg agagggccat
1561

gacgaaagac aacaatctgt tggggcgctt cgagctgagc ggcatccctc cggcccccag
1621

gggcgtgccc cagatcgagg tgaccttcga catcgatgcc aacggcatcc tgaacgtcac
1681

ggccacggac aagagcaccg gcaaggccaa caagatcacc atcaccaacg acaagggccg
1741

cctgagcaag gaggagatcg agcgcatggt gcaggaggcg gagaagtaca aagcggagga
1801

cgaggtgcag cgcgagaggg tgtcagccaa gaacgccctg gagtcctacg ccttcaacat
1861

gaagagcgcc gtggaggatg aggggctcaa gggcaagatc agcgaggcgg acaagaagaa
1921

ggtgctggac aagtgtcaag aggtcatctc gtggctggac gccaacacct tggccgagaa
1981

ggacgagttt gagcacaaga ggaaggagct ggagcaggtg tgtaacccca tcatcagcgg
2041

actgtaccag ggtgccggtg gtcccgggcc tgggggcttc ggggctcagg gtcccaaggg
2101

agggtctggg tcaggcccca ccattgagga ggtagattag gggcctttcc aagattgctg
2161

tttttgtttt ggagcttcaa gactttgcat ttcctagtat ttctgtttgt cagttctcaa
2221

tttcctgtgt ttgcaatgtt gaaatttttt ggtgaagtac tgaacttgct ttttttccgg
2281

tttctacatg cagagatgaa tttatactgc catcttacga ctatttcttc tttttaatac
2341

acttaactca ggccattttt taagttggtt acttcaaagt aaataaactt taaaattcaa

Human HSPA1A Gene Sequence

(SEQ ID NO: 94)

atgtaccggatgcagctgctgagctgtatcgccctgtctctggccctggtcaccaattctgccaaagccgc

ggcgatcggcatcgacctgggcaccacctactcctgcgtgggggtgttccaacacggcaaggtggagatca

tcgccaacgaccagggcaaccgcaccacccccagctacgtggccttcacggacaccgagcggctcatcggg

gatgcggccaagaaccaggtggcgctgaacccgcagaacaccgtgtttgacgcgaagcggctgatcggccg

caagttcggcgacccggtggtgcagtcggacatgaagcactggcctttccaggtgatcaacgacggagaca

agcccaaggtgcaggtgagctacaagggggagaccaaggcattctaccccgaggagatctcgtccatggtg

ctgaccaagatgaaggagatcgccgaggcgtacctgggctacccggtgaccaacgcggtgatcaccgtgcc

ggcctacttcaacgactcgcagcgccaggccaccaaggatgcgggtgtgatcgcggggctcaacgtgctgc

ggatcatcaacgagcccacggccgccgccatcgcctacggcctggacagaacgggcaagggggagcgcaac

gtgctcatctttgacctgggcgggggcaccttcgacgtgtccatcctgacgatcgacgacggcatcttcga

ggtgaaggccacggccggggacacccacctgggtggggaggactttgacaacaggctggtgaaccacttcg

tggaggagttcaagagaaaacacaagaaggacatcagccagaacaagcgagccgtgaggcggctgcgcacc

gcctgcgagagggccaagaggaccctgtcgtccagcacccaggccagcctggagatcgactccctgtttga

gggcatcgacttctacacgtccatcaccagggcgaggttcgaggagctgtgctccgacctgttccgaagca

ccctggagcccgtggagaaggctctgcgcgacgccaagctggacaaggcccagattcacgacctggtcctg

gtcgggggctccacccgcatccccaaggtgcagaagctgctgcaggacttcttcaacgggcgcgacctgaa

caagagcatcaaccccgacgaggctgtggcctacggggcggcggtgcaggcggccatcctgatgggggaca

agtccgagaacgtgcaggacctgctgctgctggacgtggctcccctgtcgctggggctggagacggccgga

ggcgtgatgactgccctgatcaagcgcaactccaccatccccaccaagcagacgcagatcttcaccaccta

ctccgacaaccaacccggggtgctgatccaggtgtacgagggcgagagggccatgacgaaagacaacaatc

tgttggggcgcttcgagctgagcggcatccctccggcccccaggggcgtgccccagatcgaggtgaccttc

gacatcgatgccaacggcatcctgaacgtcacggccacggacaagagcaccggcaaggccaacaagatcac

catcaccaacgacaagggccgcctgagcaaggaggagatcgagcgcatggtgcaggaggcggagaagtaca

aagcggaggacgaggtgcagcgcgagagggtgtcagccaagaacgccctggagtcctacgccttcaacatg

aagagcgccgtggaggatgaggggctcaagggcaagatcagcgaggcggacaagaagaaggttctggacaa

gtgtcaagaggtcatctcgtggctggacgccaacaccttggccgagaaggacgagtttgagcacaagagga

aggagctggagcaggtgtgtaaccccatcatcagcggactgtaccagggtgccggtggtcccgggcctggg

ggcttcggggctcagggtcccaagggagggtctgggtcaggccccaccattgaggaggtggattaa

Vascular Endothelial Growth Factor (VEGF)

The VEGF gene encodes vascular endothelial growth factor (VEGF), formerly known as fins-like tyrosine kinase (Flt-1). The VEGF protein is a heparin-biding protein that induces migration and proliferation of vascular endothelial cells.

The human VEGF gene is located on chromosome 6p21. It contains 8 exons encompassing ˜16 kilobases (kb) (NCBI Accession No. NG_008732.1). The full-length wildtype VEGF protein expressed from the human VEGF gene is 412 amino acids in length.

An exemplary human wildtype VEGF protein is or includes the sequence of SEQ ID NO: 72, SEQ ID NO: 74, SEQ ID NO: 76, SEQ ID NO: 77, SEQ ID NO: 78, or SEQ ID NO: 79. Non-limiting examples of nucleic acid encoding a wildtype VEGF protein are or include SEQ ID NO: 73 and SEQ ID NO: 75.

Non-limiting examples of protein and nucleotide sequences encoding a wildtype VEGF protein are shown below.

Human VEGF Transcript Variant 1 Protein Sequence

(SEQ ID NO: 72)

MTDRQTDTAPSPSYHLLPGRRRTVDAAASRGQGPEPAPGGGVEGVGARGVALKLFVQLLGCSRFGGAVVRA

GEAEPSGAARSASSGREEPQPEEGEEEEEKEEERGPQWRLGARKPGSWTGEAAVCADSAPAARAPQALARA

SGRGGRVARRGAEESGPPHSPSRRGSASRAGPGRASETMNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGG

GQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITM

QIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMP

WSLPGPHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR

Human VEGF Transcript Variant 1 cDNA

(SEQ ID NO: 73)

ctgacqqacagacagacagacaccgccoccagocccagctaccacctcctcccoggccggcggcggacagt

ggacgcggcggcgagccgogggcaggggccggagoccgcgccoggaggcggggtggagggggtcggggctc

goggcgtcgcactgaaacttttcgtccaacttctgggctgttctcgcttoggaggagccgtggtccgcgcg

ggggaagccgagccgagoggagccgcgagaagtqctagctogggccgggaggagccgcagccggaggaggg

ggaggaggaagaagagaaggaagaggagagggggccgcagtggcgactoggcgctoggaagccgggctcat

ggacgggtgaggcggcggtgtgcgcagacagtgctccagccgcgcgcgctccccaggccctggcccgggcc

tcgggccggggaggaagagtagctcgccgaggcgccgaggagagcgggccgccccacagcccgagccggag

agggagcgcgagccgcgccggccccggtcgggcctccgaaaccatgaactttctgctgtcttgggtgcatt

ggagccttgccttgctgctctacctccaccatgccaagtggtcccaggctgcacccatggcagaaggagga

gggcagaatcatcacgaagtggtgaagttcatggatgtctatcagcgcagctactgccatccaatcgagac

cctggtggacatcttccaggagtaccctgatgagatcgagtacatcttcaagccatcctgtgtgcccctga

tgcgatgcgggggctgctgcaatgacgagggcctggagtgtgtgcccactgaggagtccaacatcaccatg

cagattatgcggatcaaacctcaccaaggccagcacataggagagatgagcttcctacagcacaacaaatg

tgaatgcagaccaaagaaagatagagcaagacaagaaaaaaaatcagttcgaggaaagggaaaggggcaaa

aacgaaagcgcaagaaatcccggtataagtcctggagcgtgtacgttggtgcccgctgctgtctaatgccc

tggagcctccctggcccccatccctgtgggccttgctcagagcggagaaagcatttgtttgtacaagatcc

gcagacgtgtaaatgttcctgcaaaaacacagactcgcgttgcaaggcgaggcagcttgagttaaacgaac

gtacttgcagatgtgacaagccgaggcggtga

Human VEGF Transcript Variant 3 Protein Sequence

(SEQ ID NO: 74)

MTDRQTDTAPSPSYHLLPGRRRTVDAAASRGQGPEPAPGGGVEGVGARGVALKLFVQLLGCSRFGGAVVRA

GEAEPSGAARSASSGREEPQPEEGEEEEEKEEERGPQWRLGARKPGSWTGEAAVCADSAPAARAPQALARA

SGRGGRVARRGAEESGPPHSPSRRGSASRAGPGRASETMNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGG

GQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITM

QIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRPCGPCSERRKHLFVQD

PQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR

Human VEGF Transcript Variant 3 cDNA

(SEQ ID NO: 75)

ctgacggacagacagacagacaccgccoccagccccagctaccacctcctcccoggccggcggcggacagt

ggacgcggcggcgagccgcgggcaggggccggagcccgcgccoggaggcggggtggagggggtcggggctc

goggcgtcgcactgaaacttttcgtccaacttctgggctgttctcgcttcggaggagccgtggtccgcgcg

ggggaagccgagccgagoggagccgcgagaagtgctagctogggccgggaggagccgcagccggaggaggg

ggaggaggaagaagagaaggaagaggagagggggccgcagtggcgactoggcgctoggaagccgggctcat

ggacgggtgaggcggcggtgtgcgcagacagtgctccagccgcgcgcgctccccaggccctggcccgggcc

togggccggggaggaagagtagctcgccgaggcgccgaggagagogggccgccccacagcccgagccggag

agggagcgcgagccgcgccggcccoggtogggcctccgaaaccatgaactttctgctgtcttgggtgcatt

ggagccttgccttgctgctctacctccaccatgccaagtggtoccaggctgcacccatggcagaaggagga

gggcagaatcatcacgaagtggtgaagttcatggatgtctatcagcgcagctactgccatccaatcgagac

cctggtggacatcttccaggagtaccctgatgagatcgagtacatcttcaagccatcctgtgtgcccctga

tgcgatgogggggctgctgcaatgacgagggcctggagtgtgtgcccactgaggagtccaacatcaccatg

cagattatgoggatcaaacctcaccaaggccagcacataggagagatgagottcctacagcacaacaaatg

tgaatgcagaccaaagaaagatagagcaagacaagaaaaaaaatcagttcgaggaaagggaaaggggcaaa

aacgaaagcgcaagaaatcccgtocctgtgggccttgctcagagoggagaaagcatttgtttgtacaagat

ccgcagacgtgtaaatgttcctgcaaaaacacagactcgcgttgcaaggcgaggcagcttgagttaa

acgaacgtacttgcagatgtgacaagccgaggcggtga

Mature Human VEGF-A

(SEQ ID NO: 76)

APMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPT

EESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVG

ARCCLMPWSLPGPHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR

Mature Human VEGF-B

(SEQ ID NO: 77)

PVSQPDAPGHQRKVVSWIDVYTRATCQPREVVVPLTVELMGTVAKQLVPSCVTVQRCGGCCPDDGLECVPT

GQHQVRMQILMIRYPSSQLGEMSLEEHSQCECRPKKKDSAVKPDRAATPHHRPQPRSVPGWDSAPGAPSPA

DITHPTPAPGPSAHAAPSTTSALTPGPAAAAADAAASSVAKGGA

Mature Human VEGF-C

(SEQ ID NO: 78)

AHYNTEILKSIDNEWRKTQCMPREVCIDVGKEFGVATNTFFKPPCVSVYRCGGCCNSEGLQCMNTSTSYLS

KTLFEITVPLSQGPKPVTISFANHTSCRCMSKLDVYRQVHSIIRR

Mature Human VEGF-D

(SEQ ID NO: 79)

FAATFYDIETLKVIDEEWQRTQCSPRETCVEVASELGKSTNTFFKPPCVNVFRCGGCCNEESLICMNTSTS

YISKQLFEISVPLTSVPELVPVKVANHTGCKCLPTAPRHPYSIIRR

In some embodiments of any of the compositions described herein, the VEGF protein comprises a sequence that is at least 75% (e.g., at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%) identical to SEQ ID NO: 72.

A non-limiting example of a human wildtype VEGF genomic DNA sequence is SEQ ID NO: 80. The exons in SEQ ID NO: 80 are: nucleotide positions 1-1104 (exon 1); nucleotide positions 4133-4184 (exon 2) and nucleotide positions 7261-7457 (exon 3); nucleotide positions 8252-8328 (exon 4); nucleotide positions 8681-8710 (exon 5); nucleotide positions 10524-10646 (exon 6); nucleotide positions 11748-11879 (exon 7); and nucleotide positions 14333-16279 (exon 8). The introns in SEQ ID NO: 80 are: nucleotide positions 1105-4132 (intron 1); nucleotide positions 4185-7260 (intron 2); nucleotide positions 7458-8251 (intron 3); nucleotide positions 8329-8680 (intron 4); nucleotide positions 8711-10523 (intron 5); nucleotide positions 10647-11747 (intron 6); and nucleotide positions 11880-14332 (intron 7).

Human VEGF-A Gene (NCBI Accession No.NG_008732.1)

(SEQ ID NO: 80)

1
cgcctgtaat cccagcactc tgggaggcag aggtgggccg atcacttgag gtcaggagtt

61
cgagaccagc ctgggcaaca tggtgaaaca ccatctctac taaaaacaca aaaattagcc

121
aggtgtggtg gcaggcacct gcagtcccag ctactccgga ggctgaggca ggagaattgc

181
tcgaacctgg gaggcagggg ttgcagtgag ccgacatggc gccactgcac tccagtctgg

241
gcgacagagt gagaccctat ctcaaaaaaa aaaaaaaaaa aaaaagaccc aactcaagta

301
tcatctccag gaagccttcc cctactccca gcaattaaat gctcctcaga gaattcccat

361
ttttggttta ctotttggtt tacctccaga caggaagocc ccactgacac tgttgtagtc

421
ccagggtgca acacaaagca gagatcacaa gctgagttta ataattgctt gtggaataca

481
tgtcccaagc cacctcctgc aggaagccct tccagatgcc cattctagcc agtctggctc

541
tttgcttcca taccttcaca acacttgtgc ctcccccagg gcctctttct catcttgctt

601
tctggggcag ctgtgtgcac atttgtctgt gtgcagcaac tctctaaggc agggattttt

661
actcctattt ttgatgaggg gagctgtggc tcagagaggt tgaataacct aaggccacac

721
agtgagtggc agagccagga atgtgacttg ggtccatttg aatccaaagt ccctgtactt

781
tccactgccc tacctagatg tccctgtacc tcctataaaa tcagcatgga gcctggtgcc

841
tggtagtccc tacaaatatt cacaaattgg agcttagctc agctctcagg caaggcccag

901
gtcaaaaggg cagatacagc tttgggacct tagttgccac cacatgccat accttcttcc

961
cagcagaagg actccctcca agacagggta ggggtggagg atgtgaacag gggcagaaat

1021
gggcatgttt tggggtcaga cttggaggaa tagcagagat tggagtgtca gaaggtgagc

1081
atgcctgggg gtgttgggga gatgcaattc atcagggaca gcttagtgtc aggggattag

1141
actggggccc atgaaggaga ggcagaggct gatgggccta ggggtggtgt gggtaggtga

1201
gcttccccag acagtgactc tgccctgccc tctctccagc taggtcctct tccccattcc

1261
ttcccccttt cctgactgga tcctcttggg agagttaccc tccttggctt cctctgctcc

1321
aatcttttta tcagttggcc atcattactt atcattacct caagtcaaac ctccagatcc

1381
acatggggct aggacattgg cactggacca aagaggccct ttcctttgct ttctctttgt

1441
ctttttaatg cttbittgca aagacctagg cggggagaga gagagagaga gagagacaga

1501
gattgaccca cagtcagggt cagggaattg aggggaacca acccaattct ctctccttca

1561
attcaccagg tttgtatcct gcccttcctg cagatcagtg tcctgctagt cacctggggg

1621
tcaggggatg gagtgaagga caagacctcc ttccattgca gtgaagccac ttggagaaat

1681
gtgtggaaaa cagcaagacc cagtgactct ctcctcacct tctttccaat ctcaggagag

1741
attttgtccc ttcatccacc ggcttctaga ttaaccaccc acacccacac aggcgagagt

1801
ttccctgaat attggaggtg acaggacatc aggacaaagt acaactattg tgccttggcc

1861
caatcactac tttctttgtc tggggccgcc gctggctcct ggctgccttt cgcacttttc

1921
tccaccccca cccctttctc cccttccccc tcacctggaa caccttcccc ttcctccttg

1981
gctccttctg aactgccttc agagccacag actgbjggga gtggccactg cgctcccaag

2041
gtgaggccct ccaagojggg ccgagtttgc ccctcaactg ggagccagca tgacctctgt

2101
gtgggctgct ctctgcttca ctgccccttc ccccaatctg ctaggtgacc ctgggcccct

2161
ttgtgccctc tctgggcctt cggaggattc tttggggaga cagtctgctc tgacgcccct

2221
tcccctgcag caagcagcct ggggagggag gtgaggataa gtgaagtcaa gttgttcagg

2281
gggctaagcc catggaaggg aagatgccac agagatacat gtggtcttgt gattgttgtt

2341
ttgtgctttt tccccttttt tgaaagctca ggtgactagg tgacttgagc ttttaatttg

2401
gtgacaatgt gggcactggc tgagtcctta agagtacatt gttgtaaatg ccggtgacaa

2461
cacactgggg catgggatcc agagttaacc cctccaggtc acagccaggt tatatctcca

2521
caatgaaggg gggaggtggg ccatactttc tcgccctaat gaaggtagct caaaaacccc

2581
taggccaggt tgtaatccta gccttatata aaaggaattc tgtgccctca ctcccctgga

2641
tccctgggca aagccccaga gggaaacaca aacaggttgt tgtaacacac cttgctgggt

2701
accaccatgg aggacagttg gcttatgggg gtggggggtg cctggggcca cggagtgact

2761
ggtgatggct atccctcctt ggaacccctc cagcctcctc ttagcttcag atttgtttat

2821
ttgtttttta ctaagacctg ctctttcagg tctgttggct cttttagggg ctgaagaagg

2881
ccgagttgag aagggatgca agggaggggg ccagaatgag cccttagggc tcagagcctc

2941
catcctgccc caagatgtct acagcttgtg ctcctggggt gctagaggcg cacaaggagg

3001
aaagttagtg gcttcccttc catatcccgt tcatcagcct agagcatgga gcccaggtga

3061
ggaggcctgc ctgggagggg gccctgagcc aggaaataaa catttactaa ctgtacaaag

3121
accttgtccc tgctgcbggg gagcctgcca agtggtggag acaggactag tgcacgaatg

3181
atggaaaggg agggttgggg tgggtgggag ccagcccttt tcctcataag ggccttagga

3241
caccataccg atggaactgg gggtactggg gaggtaacct agcacctcca ccaaaccaca

3301
gcaacatgtg ctgaggatgg ggctgactag gtaagctccc tggagcgttt tggttaaatt

3361
gagggaaatt gctgcattcc cattctcagt ccatgcctcc acagaggcta tgccagctgt

3421
aggccagacc ctggcaagat ctgggtggat aatcagactg actggtccca ctcttcccac

3481
aggcctcaga gccccaactt tgttccctgg ggcagcctgg aaatagccag gtcagaaacc

3541
agctaggaat ttttccaagc tgcttcctat atgcaagaat gggatggggc ctttgggagc

3601
acttagggaa gatgtggaga gttggaggaa aagggggctt ggaggtaagg gaggggactg

3661
ggggaaggat aggggagaag ctgtgagcct ggagaagtag ccaagggatc ctgagggaat

3721
gggggagctg agacgaaacc cccatttcta ttcagaagat gagctatgag tctgggcttg

3781
ggctgataga agccttggcc cctggcctgg tgggagctct gggcagctgg cctacagacg

3841
ttccttagtg ctggcgggta ggtttgaatc atcacgcagg ccctggcctc cacccgcccc

3901
caccagcccc ctggcctcag ttccctggca acatctgggg ttgggggggc agcaggaaca

3961
agggcctctg tctgcccagc tgcctccccc tttgggtttt gccagactcc acagtgcata

4021
cgtgggctcc aacaggtcct cttccctccc agtcactgac taaccccgga accacacagc

4081
ttcccgttct cagctccaca aacttggtgc caaattcttc tcccctggga agcatccctg

4141
gacacttccc aaaggacccc agtcactcca gcctgttggc tgccgctcac tttgatgtct

4201
gcaggccaga tgagggctcc agatggcaca ttgtcagagg gacacactgt ggcccctgtg

4261
cccagccctg ggctctctgt acatgaagca actccagtcc caaatatgta gctgtttggg

4321
aggtcagaaa tagggggtcc aggagcaaac tccccccacc ccctttccaa agcccattcc

4381
ctctttagcc agagccgggg tgtgcagacg gcagtcacta gggggcgctc ggccaccaca

4441
gggaagctgg gtgaatggag cgagcagcgt cttcgagagt gaggacgtgt gtgtctgtgt

4501
gggtgagtga gtgtgtgcgt gtggggttga gggcgttgga gcjgggagaa ggccaggggt

4561
cactccagga ttccaataga tctgtgtgtc cctctcccca cccgtccctg tccggctctc

4621
cgccttcccc tgcccccttc aatattccta gcaaagaggg aacggctctc aggccctgtc

4681
cgcacgtaac ctcactttcc tgctccctcc tcgccaatgc cccgcgggcg cgtgtctctg

4741
gacagagttt cogggggcgg atgggtaatt ttcaggctgt gaaccttggt gggggtcgag

4801
cttccccttc attgojgcgg gctgcgggcc aggcttcact gagcgtccgc agagcccggg

4861
cccgagccgc gtgtggaagg gctgaggctc gcctgtcccc gccccccggg gcgggccggg

4921
ggcggggtcc cggcggggcg gagccatgcg cccccccctt ttttttttaa aagtcggctg

4981
gtagojggga ggatcgcgga ggcttggggc agccgggtag ctcggaggtc gtggcgctgg

5041
gggctagcac cagcgctctg tcgggaggcg cagcggttag gtggaccggt cagcggactc

5101
accggccagg gcgctoggtg ctggaatttg atattcattg atccgggttt tatccctctt

5161
cttttttctt aaacattttt ttttaaaact gtattgtttc tcgttttaat ttatttttgc

5221
ttgccattcc ccacttgaat cgggccgacg gcttggggag attgctctac ttccccaaat

5281
cactgtggat tttggaaacc agcagaaaga ggaaagaggt agcaagagct ccagagagaa

5341
gtcgaggaag agagagacgg ggtcagagag agcgcgcggg cgtgcgagca gcgaaagcga

5401
caggggcaaa gtgagtgacc tgcttttggg ggtgaccgcc ggagcgcggc gtgagccctc

5461
ccccttggga tcccgcagct gaccagtcgc gctgacggac agacagacag acaccgcccc

5521
cagccccagc taccacctcc tcccojgccg gcggcggaca gtggacgcgg cggcgagccg

5581
cgggcagggg ccggagcccg cgcccggagg cggggtggag ggggtcgggg ctcgcggcgt

5641
cgcactgaaa cttttcgtcc aacttctggg ctgttctcgc ttcggaggag ccgtggtccg

5701
cgcgggggaa gccgagccga gcggagccgc gagaagtgct agctcgggcc gggaggagcc

5761
gcagccggag gagggggagg aggaagaaga gaaggaagag gagagggggc cgcagtggcg

5821
actojgcgct cggaagccgg gctcatggac gggtgaggcg gcggtgtgcg cagacagtgc

5881
tccagccgcg cgcgctcccc aggccctggc cojggcctcg ggccggggag gaagagtagc

5941
tcgccgaggc gccgaggaga gojggccgcc ccacagcccg agccggagag ggagcgcgag

6001
ccgcgccggc ccoggtojgg cctccgaaac catgaacttt ctgctgtctt gggtgcattg

6061
gagccttgcc ttgctgctct acctccacca tgccaaggta agoggtcgtg ccctgctggc

6121
gccgcgggcc gctgcgagcg cctctccogg ctggggacgt gcgtgcgagc gcgcgcgtgg

6181
gggctccgtg ccccacgcgg gtccatgggc accaggcgtg cggcgtcccc ctctgtcgtc

6241
ttaggtgcag ggggaggggg cgcgcgcgct aggtgggagg gtacccggag agaggctcac

6301
cgcccacgcg ggccctgccc acccaccgga gtcaccgcac gtacgatctg ggccgaccag

6361
ccgagggcgg gagccggagg aggaggccga gggggcbggg cttgcgttgc cgctgccggc

6421
tgaagtttgc tccojgccgc tggtccogga cgaactggaa gtctgagcag cgggggcggg

6481
agccagagac cagtgggcag ggggtgctcg gaccttggac cgcgggaggg cagagagcgt

6541
ggagggggca gggcgcagga gggagagggg gcttgctgtc actgccactc ggtctcttca

6601
gccctcgccg cgagtttggg aaaagttttg gggtggattg ctgoggggac cccccctccc

6661
tgctgggcca cctgcgccgc gccaaccccg ccoitccccg ctcgcgtccc gctcggtgcc

6721
cgccctcccc cgccojgccg ggtgcgcgcg gcgcggagcc gattacatca gcccgggcct

6781
ggccggccgc gtgttcccgg agcctcggct gcccgaatgg ggagcccaga gtggcgagcg

6841
gcacccctcc ccccgccagc cctccgcggg aaggtgacct ctcgaggtag ccccagcccg

6901
gggatccaga gaaccatccc taccccttcc tactgtctcc agaccctacc tctgcccagt

6961
gctaggagga atttcctgac gccccttctc ttcacccatt tcctttttag cctggagaga

7021
agcccctgtc accccgctta ttttcatttc tctctgcgga gaagatccat ctaacccctt

7081
tctggcccca gagtccaggg aaaggatgat cactgtcaga agtcgtggcg cgggagccca

7141
ctgggcgctt tgtcacattc caccgaaagt cccgacttgg tgacagtgtg cttcccttcc

7201
ctcgccaaca gttccgagtg agcbitgott tagctotcgt gggggtgggt caagggagga

7261
tttgaagagt cattgcccca ctttaccctt ttggagaaat ggcttgaaat ttgctgtgac

7321
acgggcagca tgggaatagt ccttcctgaa ccctggaaag gagctcctgc cagccttgca

7381
cacactttgt cctggtgaaa ggcagccctg gagcaggtgt ttttttggaa ctccaaacct

7441
gcccacccaa cttgcttctg aaagggactc taaagggtcc ctttccgctc ctctctgacg

7501
ccttccctca gccagaattc ccttggagag gaggcaagag gaaagccatg gacaggggtc

7561
gctgctaaca ccgcaagttc ctcagaccct ggcacaaagg ccttggctac aggcctccaa

7621
gtagggagga gggggaggag tggctgcctg gccacagtgt gaccttcaga ggcccccaga

7681
gaaggacacc tggcccctgc ctgcctagaa ccgcccctcc tgtgctccct ggccttggaa

7741
ggggtatgaa atttccgtcc cctttcctcc ttggggccca ggaggagtgg agggtcccgg

7801
gagaatattg tcagggggaa ggcagggggt gtcatgggaa tgggtgaggg ggctgaggtg

7861
cagaatccag ggggtccctg caggagccgc agtggtaagc tgtccagctg gaagcctggt

7921
aactgtbitt ttctcttgag aggggcttcc tgtgaccttg gctgtctctg ggagcagggc

7981
tggggtacct gagtggggtg catttggggt gtttgggaag gagagggaaa gaaagatgga

8041
cagtgggact ctcccctagc agggtctggt gttccgtagg ctagagtgcc cctctgctct

8101
gcgagtgctg ggcgggaggg gagttggtga gagctggaga cccccaggaa gggctggcag

8161
aagcctttcc ttttgggtgc bitcaggtcc gcatgtcttg gcttgttgac cttcacagct

8221
tctggcgagg ggaggaatga tctgatgcgg gtggggaggg ttagaggagg cctcaggcct

8281
aaggtggtgc agggggcccc ctaggggctg ggcagtgcca aggcataaaa gccttccctg

8341
gtccctggtg gcatttgaag gtgcccaggt gagaggggct tggcacctcc tcaccctggg

8401
agggagaaga aaccagggaa caggtaggag tgggagacag gtgaggcttt ggaaatctat

8461
tgaggctctg gagagatttg tgtagagagg aaaatgtggt tctcccccag ggtctcctcc

8521
tgggttttta ccctctaagc aacctgtggg catgcbjggt tattcctaag gactagaaga

8581
gcttggatgg gggagggtgg ttggtgccct toggtcctcg gcacccccct ccgtctccaa

8641
caccagctca ccctggtatt tttcatgtca gcaggagaag gtcaccatgt tgtttttctc

8701
gcccctagtc cttccttcct gccccagtcc aaatttgtcc tcctatttga ccttaatact

8761
taccatggct ttggaccagg gaactagggg gatagtgaga gcagggagag ggaagtgtgg

8821
ggaaggtaca ggggacctcg acagtgaagc attctggggt tttcctcctg catttcgagc

8881
tccccagccc ccaacatctg gttagtcttt aacttcctcg ggttcataac catagcagtc

8941
caggagtggt gggcatattc tttgcccgtg gggacccccg gttgtgtcct gttcgactca

9001
gaagacttgg agaagccaga ggctgttggt gggagggaag tgaggaggga ggaggggctg

9061
ggtggcbggg cctgtgcacc ccagcccctg cccatgccca tgccttgctc tctttctgtc

9121
ctcagtggtc ccaggctgca cccatggcag aaggaggagg gcagaatcat cacgaaggtg

9181
agtccccctg gcbgttggat ggggttccct gtcctctcag gggatgggtg gatggcctaa

9241
ttcctttttc ttcagaactg tggggaggaa ggggaagggg cacaggaata taaggatcaa

9301
gaaagaaaga gcbjggcacc acgaggttca ccctcagttt cgtgaggact ctccgctgtt

9361
caggtctctg ctagaagtag gacttgttgc ctttttcttc tgctctttcc agtaaaattt

9421
tatttggaga aggagtcgtg cgcacagagc aggaagacag tgttcaggga tcctaggtgt

9481
tgggggaagt gtcccttgtt tcccotagct cccaggggag agtggacatt tagtgtcatt

9541
tcctatatag acatgtccca tttgtgggaa ctgtgaccct tcctgtgtga gctggaggca

9601
cagagggctc agcctaatgg gatctctcct cccttccctg gtttgcattc ctttgggggt

9661
ggagaaaacc ccatttgact atgttcgggt gctgtgaact tccctcccag gccagcagag

9721
ggctggctgt agctcccagg cgccccgccc ccctgcccaa ccccgagtcc gcctgccttt

9781
bittccgttg tggtttggat cctcccattt ctctggggac accctggctc tccccaccac

9841
tgactgtggc ctgtgctctc cacctctggg gagggaaggc cctggggtct tccttcccgc

9901
gagtttccct gacctaaatc tggcgtggct gggtagtggc cagcagtggt gatgcccagc

9961
ctgttctgcc tcctccttcc ccaccccagg agccctttcc ttggcctagg acctggcttc

10021
tcagccactg accggccccc tgcttccagt gcgccactta ccccttccag cttcccagtg

10081
gtctctggtc tgggagaggc aggacaaagg tctttgtttg ctggagaaaa ggttgtctgc

10141
gataaataag gaaaaccacg aaagcctggt bittggagtg tacgtgtgtg ctcccccagg

10201
cagtggaggc cagccctcct tggaggggcg gctgcctgat gaaggatgcg ggtgaggttc

10261
cccgcctcca cctcccatgg gacttgggga ttcattccaa ggggaagctt tttgggggaa

10321
ttcctacccc aggtcttttt accctcagtt accaacccct tgcccaggcc agaccttcct

10381
gctatcccct cctgggccac aagcctggcc ctcctctgtc ccaattgtga tgaaggggca

10441
gttcaaaact tcttgattag tcatcttctc ccctatcgac ttggctttaa aaaatgacct

10501
tttcagactt ctagtctcgt tcactctttt tgatgatgct ttgccgtaac ccttcgtggg

10561
tagagaagga ttctgtgccc attggtggtc tggataaaag aaatagagac ctcacaggaa

10621
gcagtggact ggcctgtttc cccactgttc tttctgtttt cacacctgtg gccttctccc

10681
caccttcttc ccaatcaacc tattgtgtac atagcccccc tcattgtcct ttattcttct

10741
ggaaagcaga ccttggaggg aggagtgagg gggaggctca gcbgtggtct ctggggggtg

10801
ggggttggga gcbggggtgg aagtccacga agcatacact taagatgctt tggtgaagtt

10861
ctaaacttca tattacccag gctgaaaaaa gagcacttgt tcctagggct ggaaatggaa

10921
gccaaaacac cacctttttc agcctgtttc agcatcttta gagatcagcc caacccactt

10981
acacagttga gcagagttgg aggcctagag aggggaggga ctggcccaag gtcataccaa

11041
ctcatggcca gagcctgggc ctcctcactg gccaggtgtt atttcttccc tctgggtagg

11101
gaacctattt cagggacagg attgctatgt ggtagtggtg gtggggtgcg ataggcgtgg

11161
caggcbjggc cacaatttgg agtagtcatg ccagagtcct gcatttattt attctcaagg

11221
gccccgcctc tgtggcccag aattacccct tcatgctcca gtgcacccca ggcttcgtgg

11281
ccagcctggg aaactgtctc taccctggtc tcccttcaga tcagcttcta gaaatgtttc

11341
gtggctacag tggcagcact gttttttcca tgatgcaagc agtttgccct cttgggcggg

11401
gttatcagtg gctggcaggg ctggcacagc gtgtccgccc actgccacct gtgggttcca

11461
ggagggccca gcccctgtgc tgatgcccac caccttctca gctcatgtct ggggaagagg

11521
actggcaggg ggaaaggtgc ctcctcctga aaggtgcctc ctctgttttt gcctaatata

11581
ggcttgggaa cactttgatg tcagctaatt ctgactcctt tacttactag ctgtgcggcc

11641
ttggggcaac ttacttagcc tctttgagcc tcctgttccc catctgtaaa atggaatctc

11701
aatagtgtct aatagtacca tgtggagaaa cttgtgtgaa atgatagctg tggactactg

11761
tacacagtac tcaggatgta gtaagtgctc aataaacagc bittggtatg gttgacgtta

11821
tggtagtggt tgtggggagg acgtaggaaa ctggagacta gcttggcaaa gctggctctt

11881
cctcctttta gggaaagctt agagcatccc catggggtat acccatactc agactgtcct

11941
ctggcatcga ggttggccca ggattcagtt cagcbgtcac agtgaggtgg cgggatcaga

12001
tgtggcaggc catgtccctt ggaacttgag tacatcgtgt gatctctgga atgaaaacag

12061
gccttcacca gtgttgatgg tggaaagctt agggaagtgc ttcaaacaca gtaggaggga

12121
cttacgttag attttggaag gacttgcctg attcggaagc tccaaagagt ggcattacag

12181
agcbjggtgg agagaggggc tagccatctt ttgtgtcgcc caccgggctc atgtgtcatc

12241
gcctctcatg cagtggtgaa gttcatggat gtctatcagc gcagctactg ccatccaatc

12301
gagaccctgg tggacatctt ccaggagtac cctgatgaga tcgagtacat cttcaagcca

12361
tcctgtgtgc ccctgatgcg atgojggggc tgctgcaatg acgagggcct ggagtgtgtg

12421
cccactgagg agtccaacat caccatgcag gtgggcatct ttgggaagtg gggcaagggg

12481
gggataggga ggggggtaac actttgggaa caggtggtcc caggtcgttt cctggctaga

12541
tttgccttgt ctggctcctg cccctgagtt gcacagggga ggtatggtgg ggtcttgcct

12601
tctgtggaga agatgcttca ttcccagccc aggttcccag caagccccaa ccatctcctt

12661
ctccctgatg gttgcccatg ggctcaggag gggacagatg gatgcctgtg tcaggagccc

12721
ctctctccct ctcttggaga gagtcctgag tgccccccct tcttgggggc tttgtttggg

12781
aagctggatg agcctggtcc atggagagtt taaaaagtct tttggtgtta cctggtaatg

12841
gggcacatct cagcccagat agggtgggag ggagctgtga aacacaggga gggggttgct

12901
ttcgggtatc tactaggagt cagggtgaag cctagagagg atgaaagaag gggaggggat

12961
ggggagtggt aagaacctag gatttgaatt cccagcctgg ccaacccttg cagccatgtc

13021
ttggcctcaa gtggaacaag ggctccttga ggccagcagg gttgggggag ttggggtggg

13081
cctgagcctc tttcctgcta gagctcttgg tcctccctgc ctccaccacc catccctgct

13141
ctgcagaacc cctgggtgct gagtggcagg agccccaggg ttgtcccatc tgggtatggc

13201
tggcbgggtc actaacctct gtgatctgct tccttccttt ccagattatg cggatcaaac

13261
ctcaccaagg ccagcacata ggagagatga gcttcctaca gcacaacaaa tgtgaatgca

13321
ggtgaggatg tagtcacgga ttcattatca gcaagtggct gcagggtgcc tgatctgtgc

13381
cagggttaag catgctgtac tttttggccc ccgtccagct tcccgctatg tgacctttgg

13441
cattttactt caatgtgcct cagtttctac atctgtaaaa tgggcacaat agtagtatac

13501
ttcatagcat tgttataatg attaaacaag ttatatatga aaagattaaa acagtgttgc

13561
tccataataa atgcbgtttt tactgtgatt attattgttg ttatccctat cattatcatc

13621
accatcttaa cccttccctg ttttgctctt ttctctctcc ctacccattg cagaccaaag

13681
aaagatagag caagacaaga aaagtaagtg gccctgactt tagcacttct ccctctccat

13741
ggccggttgt cttggtttgg ggctcttggc tacctctgtt gggggctccc atagcctccc

13801
tgggtcaggg acttggtctt gtgggggact tgtggtggca gcaacaatgg gatggagcca

13861
actccaggat gatggctcta gggctagtga gaaaacatag ccaggagcct ggcacttcct

13921
ttggaaggga caatgccttc tgggtctcca gatcattcct gaccaggact tgctgtttcg

13981
gtgtgtcagg gggcactgtg gacactggct cactggcttg ctctaggaca cccacagtgg

14041
ggagagggag tgggtggcag agaggccagc ttttgtgtgt cagaggaaat ggcctctttt

14101
ggtggctgct gtgacggtgc agttggatgc gaggccggct ggagggtggt ttctcagtgc

14161
atgccctcct gtaggcggca ggcggcagac acacagccct cttggccagg gagaaaaagt

14221
tgaatgttgg tcattttcag aggcttgtga gtgctccgtg ttaaggggca ggtaggatgg

14281
ggtgggggac aaggtctggc ggcagtaacc cttcaagaca gggtgggcgg ctggcatcag

14341
caagagcttg cagggaaaga gagactgaga gagagcacct gtgccctgcc ctttccccca

14401
caccatcttg tctgcctcca gtgcbgtgcg gacattgaag cccccaccag gcctcaaccc

14461
cttgcctctt ccctcagctc ccagcttcca gagcgagggg atgcggaaac cttccttcca

14521
ccctttggtg ctttctccta agggggacag acttgccctc tctggtccct tctccccctc

14581
ctttcttccc tgtgacagac atcctgaggt gtgttctctt gggcttggca ggcatggaga

14641
gctctggttc tcttgaaggg gacaggctac agcctgcccc ccttcctgtt tccccaaatg

14701
actgctctgc catggggaga gtagggggct cgcctgggct cggaagagtg tctggtgaga

14761
tggtgtagca ggctttgaca ggcbjgggag agaactccct gccaagtacc gcccaagcct

14821
ctcctcccca gacctcctta actcccaccc catcctgctg cctgcccagg gctccaggac

14881
acccagccct gcctcccagt ccaggtcgtg ctgagcaggc tggtgttgct cttggttccg

14941
tgccagctcc caaggtagcc gcttccccca caccgggatt cccagaggtt ctgtcgcagt

15001
tgcaaatgaa ggcacaaggc ctgatacaca gccctccctc ccactcctgc tccccatcca

15061
ggcaggtctc tgaccttctc cccaaagtct ggcctacctt ttatcacccc cggaccttca

15121
gggtcagact tggacagggc tgctgggcaa agagccttcc ctcaggcttt gccccctgcc

15181
ggggactggg agccactgtg agtgtggaga cctttgggtc ctgtgccctc cacccagtct

15241
cggcttccca ccaaagcctt gtcaggggct gggtttgcca tcccatggtg ggcagcgtga

15301
ggagaagaaa gagccatcga gtgcttgctg cccagacacg cctgtgtgcg cccgcgcatg

15361
cctccccaga gaccacctgc ctcctgacac ttcctccggg aagojgccct gtgtggcttt

15421
gctttggtog ttcccccatc cctgcccacc ttaccacttc ttttactccc cccaccgccc

15481
ccgctctctc tctgtctctg tttttttatt ttccagaaaa tcagttcgag gaaagggaaa

15541
ggggcaaaaa cgaaagcgca agaaatcccg gtataagtcc tggagcgtgt acgttggtgc

15601
ccgctgctgt ctaatgccct ggagcctccc tggcccccag tacaacctcc gcctgccatt

15661
ccctgtaacc ctgcctccct cccctggtcc ttccctggct ctcatcctcc tggcccgtgt

15721
ctctctctca ctctctcact ccactaattg gcaccaacgg gtagatttgg tggtggcatt

15781
gctggtccag ggttggggtg aatgggggtg ccgacttggc ctggaggatt aagggagggg

15841
accctggctt ggcbjggcac cgattttctc tcacccactg ggcactggtg gcgggcccat

15901
gttggcacag gtgcctgctc acccaactgg tttccattgc tctaggcttc tgcactcgtc

15961
tggaagctga gggtggtggg gagggcagac atggcccaag aagggcbgtg aatgactgga

16021
ggcagcttgc tgaatgactc cttggctgaa ggaggagctt gggtgggatc agacaccatg

16081
tggcggcctc ccttcatctg gtggaagtgc cctggctcct cacggaggtg gggcctctgg

16141
aggggagccc cctattccgg cccaacccat ggcacccaca gaggcctcct tgcagggcag

16201
cctcttcctc tgggtoggag gcbgtggtgg gccctgccct gggccctctg gccaccagcg

16261
gcctggcctg gggacaccgc ctccgggctt agcctcccat cacaccctac tttagcccac

16321
cttggtggaa gggcctggac atgagccttg cacggggaga aggtggcccc tgattgccat

16381
ccccagcagg tgaagagtca aggcgtgctc cgatgggggc aacagcagtt gggtccctgt

16441
ggcctgagac tcacccttgt ctcccagaga cacagcattg ccccttatgg cagcctctcc

16501
ctgcactctc tgcccgtctg tgcccgcctc ttcctgojgc aggtgtccta gccagtgctg

16561
cctctttccg ccgctctctc tgtcttttgc tgtagcgctc ggatccttcc agggcctggg

16621
ggctgaccgg ctgggtgggg gtgcagctgc ggacatgtta gggggtgttg catggtgatt

16681
ttttttctct ctctctgctg atgctctagc ttagatgtct ttccttttgc ctttttgcag

16741
tccctgtggg ccttgctcag agcggagaaa gcatttgttt gtacaagatc cgcagacgtg

16801
taaatgttcc tgcaaaaaca cagactcgcg ttgcaaggcg aggcagcttg agttaaacga

16861
acgtacttgc aggttggttc ccagagggca agcaagtcag agaggggcat cacacagaga

16921
tggggagaga gagagagaaa gagagtgagc gagcgagcga gojggagagc gcctgagagg

16981
ggccagctgc ttgctcagtt tctagctgcc tgcctggtga ctgctgcctt ctctgctttt

17041
aaggcccctg tggtgggctg caggcactgg tccagcctgg cggggcctgt tccgaggttg

17101
ccctggttgc ctgagtggta ggcbggtgtg gcttagtgta gtggtgtgga cgcaagctgt

17161
gtgttgtgtc ctgtggtcct tctgctcata gtggctgttg gtcctgatgt tattactacc

17221
tctggtagta atgctgagaa gctgaaagcc gattccaggt gtggacaatg tcaacaaagc

17281
acagatgctc tcgctggggc cttgcctcgg ccctttgaag tctgcatggc tgggcttctc

17341
actcactcag tgtttcttgc tgggggaagg aattgagtct cccacttcag actgggcctc

17401
cctgaggaaa gggttgtgtc tccccactca gactgaggtt ccctgagggt agggctgtgt

17461
ctctcccctc cgacctgggc tccctgatag ggctgtctcc ccgctcagac tgaggctccc

17521
tcaggccagg gctatgtctc cctcctcaga ctggggctct gagggcaagg ggtctggctg

17581
ttcgtttagg atggggcact tttgcctaca cactgaagga gctgtagcat ccaagaatac

17641
tagatacctt taatcctcca ccagtcatgg tgacaacccc aagcagccca cacattttca

17701
agtgccccca ggatgcgtgg agggaggggt ctgtgcccat tctcctgaca ttagcctgtg

17761
agctccgtaa gccojggcct cgtttacgta cctttgtgag cccojggcat ctgtacctct

17821
ttcctttgcc catactgggg accaaggaag tgtcaagtgc atgagtgaat gtgtgactca

17881
gttcagaggg tgaggtcagg agcacagggt cgggacaggt ggctggcatc ttttaatgcc

17941
ttagcttatg ttctttatac caacttggcc tgtgctcaga gtgagggagg ccctgggggt

18001
cagggtaagc gtcagtcagg gaggcaagac tttgtgggga tttcctagac agggccaagg

18061
cacccccagc tcaccccgag gcbgtgttag ggaagtcctt ggagtgtctc ccctccccca

18121
gcaatgttct tgtggcttgt gtgtgctcag gggatgctgg gaaccaggcc tgggtagttg

18181
gtgtggggtg ctgtctgtct tggccctatg tgaaaccaag agggcgtata ttagtgctgg

18241
ggtgggggct ctgcctaact tcagggctgg atgaggggag tctcagttcc ccaggggtcc

18301
ttgggaaaga taagggactt gacattttag ggtttttagg tgattattct gctgatgggg

18361
gtttgtgtga agtgacctgg gagctaactg aagttactct aacctcccaa tacctttacc

18421
caacccccaa gctggctgta tctgggaata tcagtttcca aaattggagg cttaggactc

18481
cgtttogggg ctccccagaa gggtagggcc tgttctgcct ccttctcaca atcacccagg

18541
ggcaggggca tgctgagaaa gttcttggag gccccctttg cttcagctgg agtagtgaag

18601
ccgccgaatt gtotctoccc atcctaagtg aagcagcata tttgaaagga aagacaacct

18661
gttacctggg cctgcaacct ccaggcagct caagagagat gaggcctaca gccacagtgg

18721
gaggggacat ggggaatgga gatggtccct caccttcctg gggcctcctg ctctacgcta

18781
ccccctojgg agcctcctgt ccccagggca ggcccttgcc attgttggtc acccggccaa

18841
gcctctctgc ctcaggcgtt ctcccagaag atctgcccac tctcttcccc acaccagccc

18901
ctagagactg aactgaaaac cctcctcagc agggagcctc ttctgattaa cttcatccag

18961
ctctggtcac ccatcagctc ttaaaatgtc aagtggggac tgttctttgg tatccgttca

19021
tttgttgctt tgtaaagtgt tcccatgtcc ttgtcttgtc tcaagtagat tgcaagctca

19081
ggagggtaga ctgggagccc ctgagtggag ctgctgctca ggccggggct ccctgagggc

19141
agggctgggg ctgttctcat actggggctt tctgccccag gaccacacct tcctgtcctc

19201
tctgctctta tggtgccgga ggctgcagtg acccaggggc ccccaggaat ggggaggccg

19261
cctgcctcat cgccaggcct cctcacttgg ccctaacccc agcctttgtt ttccatttcc

19321
ctcagatgtg acaagccgag goggtgagcc gggcaggagg aaggagcctc cctcagggtt

19381
tojggaacca gatctctcac caggaaagac tgatacagaa cgatcgatac agaaaccacg

19441
ctgccgccac cacaccatca ccatcgacag aacagtcctt aatccagaaa cctgaaatga

19501
aggaagagga gactctgcgc agagcacttt gggtccggag ggcgagactc cggcggaagc

19561
attccojggc gggtgaccca gcacggtccc tcttggaatt ggattcgcca ttttattttt

19621
cttgctgcta aatcaccgag cccggaagat tagagagttt tatttctggg attcctgtag

19681
acacacccac ccacatacat acatttatat atatatatat tatatatata taaaaataaa

19741
tatctctatt ttatatatat aaaatatata tattcttttt ttaaattaac agtgctaatg

19801
ttattggtgt cttcactgga tgtatttgac tgcbgtggac ttgagttggg aggggaatgt

19861
tcccactcag atcctgacag ggaagaggag gagatgagag actctggcat gatctttttt

19921
ttgtcccact tggtggggcc agggtcctct cccctgccca ggaatgtgca aggccagggc

19981
atgggggcaa atatgaccca gttttgggaa caccgacaaa cccagccctg gcgctgagcc

20041
tctctacccc aggtcagacg gacagaaaga cagatcacag gtacagggat gaggacaccg

20101
gctctgacca ggagtttggg gagcttcagg acattgctgt gctttgggga ttccctccac

20161
atgctgcacg cgcatctcgc ccccaggggc actgcctgga agattcagga gcctgggcgg

20221
ccttcgctta ctctcacctg cttctgagtt gcccaggaga ccactggcag atgtcccggc

20281
gaagagaaga gacacattgt tggaagaagc agcccatgac agctcccctt cctgggactc

20341
gccctcatcc tcttcctgct ccccttcctg gggtgcagcc taaaaggacc tatgtcctca

20401
caccattgaa accactagtt ctgtcccccc aggagacctg gttgtgtgtg tgtgagtggt

20461
tgaccttcct ccatcccctg gtccttccct tcccttcccg aggcacagag agacagggca

20521
ggatccacgt gcccattgtg gaggcagaga aaagagaaag tgttttatat acggtactta

20581
tttaatatcc ctttttaatt agaaattaaa acagttaatt taattaaaga gtagggtttt

20641
ttttcagtat tcttggttaa tatttaattt caactattta tgagatgtat cttttgctct

20701
ctcttgctct cttatttgta coggtttttg tatataaaat tcatgtttcc aatctctctc

20761
tccctgatcg gtgacagtca ctagcttatc ttgaacagat atttaatttt gctaacactc

20821
agctctgccc tccccgatcc cctggctccc cagcacacat tcctttgaaa taaggtttca

20881
atatacatct acatactata tatatatttg gcaacttgta tttgbitgta tatatatata

20941
tatatgttta tgtatatatg tgattctgat aaaatagaca ttgctattct gttttttata

21001
tgtaaaaaca aaacaagaaa aaatagagaa ttctacatac taaatctctc tcctttttta

21061
attttaatat ttgttatcat ttatttattg gtgctactgt ttatccgtaa taattgtggg

21121
gaaaagatat taacatcacg tctttgtctc tagtgcagtt tttcgagata ttccgtagta

21181
catatttatt tttaaacaac gacaaagaaa tacagatata tcttaaaaaa aaaaaagcat

21241
tttgtattaa agaatttaat tctgatctca aagctcctct tggtttctcc ttctccattg

21301
aatccttgct ctagacttcc tcccgccccc tttccctctt cctctgggga acatggcatt

21361
tgtcttgggt ctgggaaagg tacgtctaat gtgtaggata tggggtgacc caccttgttg

21421
tgcbgggggc aaagtccttc cattttggct gagctggtcc tgggggaacc catccatcct

21481
gtcttgatat agaaggtggg aagctctggg aatgggtgga gggggagaaa cagcttagga

21541
gccaagggcc cttgcaattg gtagtgctgc cttcaggaat tagatgatcc aggcccctgt

21601
cccttagcca gggaaagaac tggccatgtc tccaagcttg ctgcccagga gacaggagag

21661
agcbgttttt gtctgtgggg gtcttgttgg ctgcaacagg ctgggagtgg gagggggatg

21721
ctgctggagg gctgtgactc cagggtgtaa cttaatttta catagtttta caccctggag

21781
ttccttgagc ctctggaaga tggacccata ggtttggtca ccactgatgg gacactccct

21841
gccccagctt gccataagct cttctctcac gtcctgctcc tgggtaaggt ggcacctatc

21901
caggtctttg acactgaagg gcagtgcttc caaattcact tcctctagcc tctcatttat

21961
tcttgcaaac catagatatg gcttgaataa atattgagcc agtcattgtg ctgctatgaa

22021
taagacacaa ttccacccct caaggatctg gtgaggatgg gtgggtgggg agacccaaaa

22081
ctataaatcc atgagcagaa aaatacataa aatgtgctgg gggcatctga tctagcttgg

22141
gagtgggagt tgtattgggg gtggtggctg gggggtggtg tcttatgaca ttatctctag

22201
gctgccactt aaagtatggt ttgaagacag ggagaacggg gojgcggagt gaaagggttg

22261
aggacatccc aggcagaagg gatagtgtga gcaaggcatg aaggtggcac ttgggcaggg

22321
gcagggagtg ggtgggcagg gtggaggctg gagacacggg caagggttag ctccaaggga

22381
gcctgcagca ccatgccaag agcctagggc ctgtcaggga tgagcagcag ccgaggggtt

22441
ttaaacactg agojgctcag tcagatagac ttttccatag gtgcctggca acagtatggg

22501
aggcagagag gccggtagag gctgttgtgg tcttccagga ggaattgtgc tggtggtggg

22561
gaagcacctt tggtgactgg cagtgccggc cattgcaagg tctcagcctc aggcagcttt

22621
tggtctagta agtgctcctt tcccaatcac tgaccacgtg ccgaccccta cattggttaa

22681
cactgaatct gcacagcagc cctgggaggt aggtgctttt tttttttttt tttttttttt

22741
gagatggagt cttgctctgt cacccaggct ggagtacaat ggtgcgatct cgggtcactg

22801
caacctccgc ctcccaggtt caagggattc tccctcctca gcctcccgag tagctgggat

22861
tacaggcacg caccatcatg cccgactaat tttbitgttt tcgtagagac ggggtttcac

22921
catgttggcc aggctggcct caaacccttg acctcaggtg atctgcccgc cttggcctcc

22981
caaagtgctg gcattacaga tgtgagccac cgcgccojgc aggtaggggc ttttttcatc

23041
ccatctggat ttttgctgga gcctttaaat tggccgcctg gcttctcctc tggccttcct

23101
ttagttgaat ctcacacaac tgccagagtg agcctgttaa aatgtgagtt aagttttggc

23161
accttttgac tcaaaacctt ccagagatag ttttactcgg agaaaaaccc aaatggcctt

23221
aaaaggcctg caccatttgg gctgcctccc tgactactca atgacttcgg gc

Human VEGF-B Gene (NCBI Accession No. NG_029823.1)

(SEQ ID NO: 81)

1
gccgtcccog ccgccgctgc ccgccgccac cggccgcccg cccgccoggc tcctccggcc

61
gcctccgctg cgctgcgctg cgctgcctgc acccagggct cgggaggggg ccgcggagga

121
gtcgcccccc gcgccojgcc cccgcccgcc gcgccojggc ccgcgccatg gggctctggc

181
tgtcgccgcc ccccgcgccg cojggctagg gcgatgojgg cgccccojgc gggcggcccc

241
ggcgggcacc atgagccctc tgctccgccg cctgctgctc gccgcactcc tgcagctggc

301
ccccgcccag gtacgtgcgg cccgacagcg cgcccgcccg cccgccgtgc cctctctcaa

361
ggttggcgga agtgaggagg cgacccgcgg cctojgccga ggggatctgc ggggtccggc

421
cttggacgcg ggcgtctojg gggccoggcg cgtgcatccc ctgggaggtg cccctccccg

481
ctggcccgcc agccccagtc tggggccact cctccgcccc accccgtccc ctgggcaccg

541
cogggggcgg ggctccctcg gtgcctgcag gacctgcttc ggtgggcact gtgcgcgctc

601
ctgatctgca tgcagccccc aaacatgctc ggctccgcgg cctggagatt tggcgcggcc

661
accagagcac ctgttgcgtt ttgggccagg gcaggtcccg ggtggccagg agaggacagg

721
taaagctaga gcagtggccg caggaacaga gcaatctgga aagatgtcag agaggtggtg

781
aagcctactg atgcaagggc aaagccccag ggacggtgac agggccacac cctcctaaag

841
tgtaccttgg gtacaggtct tttctctccc acaggcccct gtctcccagc ctgatgcccc

901
tggccaccag aggaaaggta atacttacaa aaactojgca ctagccagca ctaagagggt

961
ttgtcatggg ccctgattcc aggtgtccat catcttgtgt aactccccta gaagattcaa

1021
actattattc tacccatttc acagaggagg aaattgaggc agtgggttta ctgggatctg

1081
gataaacagg gcaggggaag acaggttgtg agggcagagt ggggagggct agtggagggt

1141
ggctgtgact tggggactgg ggaggacaga tgctgggagc agctgcagga aaaccagtga

1201
ggacttaacc cctaccggtc tgctcccagt ggtgtcatgg atagatgtgt atactcgcgc

1261
tacctgccag cccojggagg tggtggtgcc cttgactgtg gagctcatgg gcaccgtggc

1321
caaacagctg gtgcccagct gcgtgactgt gcagcgctgt ggtggctgct gccctgacga

1381
tggcctggag tgbitgccca ctgggcagca ccaagtccgg atgcaggtac tgggcaggtg

1441
gggcaacggg caggggatgc aggtactggg caggtggggc agojggcagg gtggatgctg

1501
gctggctctg gggcbggggc agcctggaga ctgatgcaca ggagacaggg ttggggggag

1561
ggcbggtggc cagcctcccg gctgttgggt gagcttttct cccttcagtc ttagagcatc

1621
ccctttctct ctctccctca ctgtcccccc tgttcttctc ctgagcacag atcctcatga

1681
tccggtaccc gagcagtcag ctgggggaga tgtccctgga agaacacagc cagtgtgaat

1741
gcaggtgcca gccaggccca acttctgagc tcgcagaggc caggcttggg gggtgctggg

1801
tatggtggtc cacagaactg gggaccaggt tcctaagagt agaaccaagg ggccgggcgt

1861
ggtagctcac gcctgtaatc ccagcacttt gggaggccga ggcgggcgga tcatgaggtc

1921
aggagatcga gaccatcctg gctaacatgg taaaaacctg tctctactaa aaaaatacaa

1981
aaaattagcc gggcgtggtg gojggcacct gtagtcccag ctactccgga ggctgaggca

2041
ggagaatggc atgaacctgg gaggcgtagc ttgcagtgag ccaagatcgt gccactgcat

2101
tccagcctgg gcgacagagc aagactctgc cacaaaaaaa aaaaaaaaaa aaaaaaaaaa

2161
agagtagagc caagggtagg ccttggatct ggggcaacaa agtaggatgc ttgggccggg

2221
ggtagtggct cacacctata atcccagcac tttgggaggc ccaggcaggc agatcacctg

2281
aggtaaggcg tttgagacca gcctggccaa catggtgaaa ccccatctct actaaaaaaa

2341
aatacaaaaa ttagccgcgc atggtggcag gtgcctgtaa tcccagctac ttgggaggct

2401
gagacaagag aatagcttga acctgggagg cggaggttgc agtgagccga gaccacgcca

2461
ctgcactcca gcctgggcaa gaagagggaa acacagtctc aaagagagag agagagagag

2521
agagagagag agagagagag taggatgctg ggatttcctg atcttcctct tgtttgtctg

2581
tgtctgtcta tcttactttt cagacctaaa aaaaaggaca gtgcbgtgaa gccagacagg

2641
tgagtctttt ggactccagc tgagtagggg tatggggagt acaagtgagt ccagaagctg

2701
ttgctcctct ttctcctccc acccgtcccc cactttccct tttcctctgc tccccaagcc

2761
bitgttctct gccccgaccc cagctctagg gaagactctt ccttcccacc ccagacatgt

2821
cgcttctcct ccctagggct gccactcccc accaccgtcc ccagccccgt tctgttccgg

2881
gcbjggactc tgccccogga gcaccctccc cagctgacat cacccatccc actccagccc

2941
caggcccctc tgcccacgct gcacccagca ccaccagcgc cctgaccccc ggacctgccg

3001
ctgccgctgc cgacgccgca gcttcctccg ttgccaaggg cggggcttag agctcaaccc

3061
agacacctgc aggtgaggcg tctgtggggt ggtgtttgtt tgggaaggca ccaaggccct

3121
gtcctggagc aggtccaggg tgagcctgcc agtaggagga gggccaggga aggggaaact

3181
gttgaatgtg ttgaacaaat atttaccaaa cagctgctgg cacctggagc tgtataagca

3241
agtccaacat tctaactcag gagtcagata caggagggac aatgccagca gaggatgtca

3301
agggcbgtgg tgaggggtac ctggcctcgt ctttcagagg tcagagatct cttggaggag

3361
gtgacatctg ccoggagtag aaatgtagga cacagctttt ccagcttgca gttcgggcct

3421
tcccagaagc ccctgtggta gacatctgcc cttacctacg ggcttcaaga ggccagggga

3481
catagtggaa cccttgtcca cccttacctg abitgtttct caccatccgt gtcccgcagt

3541
gaggccatgg ggtgaaatca tatgggcagg gccagtgggg gctcccgagg agtgtcagga

3601
ggggatgacc tttgcaaaag gttcatcctt cgccctgcag cctccagtgc ccagggccga

3661
gtggtgtggc aggatgctca ggttgtgatc ttagtgggcc cgaggcacac atgagtccag

3721
ggcbjgggct gcgctccagc cagcatgaac agatcacttc ctccctcctc aggtgccgga

3781
agctgcgaag gtgacacatg gcttttcaga ctcagcaggg tgacttgcct cagaggctat

3841
atcccagtgg gggaacaaag aggagcctgg taaaaaacag ccaagccccc aagacctcag

3901
cccaggcaga agctgctcta ggacctgggc ctctcagagg gctcttctgc catcccttgt

3961
ctccctgagg ccatcatcaa acaggacaga gttggaagag gagactggga ggcagcaaga

4021
ggggtcacat accagctcag gggagaatgg agtactgtct cagtttctaa ccactctgtg

4081
caagtaagca tcttacaact ggctcttcct cccctcacta agaagaccca aacctctgca

4141
taatgggatt tgggctttgg tacaagaact gtgaccccca accctgataa aagagatgga

4201
aggagcbgtc cctgcctgtg tcactgtttg tcactgtcca ggctggctgg tttgggcatg

4261
aatgtctgca tcactaaatc cagagcttgt cttgctccct cattgtgcag atggaggaaa

4321
tgaggactaa ggccocacag cagatoccag gcagggccag aattatgtat tcatcacttt

4381
caagttattg ccacgcatgg gagtcaggga tagcccagtc aatacagact gcctgccctc

4441
ctgctcttca ccagggttct tttctagaag gagacagcct tctgtggcca gagagcttgg

4501
ggtaggaccc agatctactg agtgaccttg cttgtcacta cccctgcctc tctgagcagc

4561
agtttccaca tgtgcacata gagggaacag aagattgctg tggttggcgt cctcgggccc

4621
cagagaagtt tgagactatc tttacgtaat agaaaagaac acttgttctt cctgccaggc

4681
a

Human VEGF-C Gene (NCBI Accession No. NG_034216.1)

(SEQ ID NO: 82)

1
acttcgggga aggggaggga ggagggggac gagggctctg gcgggtttgg aggggctgaa

61
catcgcgggg tgttctggtg tcccccgccc cgcctctcca aaaagctaca ccgacgcgga

121
ccgcggcggc gtcctccctc gccctcgctt cacctcgcgg gctccgaatg cggggagctc

181
ggatgtccgg tttcctgtga ggcttttacc tgacacccgc cgcctttccc cggcactggc

241
tgggagggcg ccctgcaaag ttgggaacgc ggagcccogg acccgctccc gccgcctccg

301
gctcgcccag ggggggtcgc cgggaggagc cojggggaga gggaccagga ggggcccgcg

361
gcctcgcagg ggcgcccgcg cccccacccc tgcccccgcc agcggaccgg tcccccaccc

421
coggtccttc caccatgcac ttgctgggct tcttctctgt ggcgtgttct ctgctcgccg

481
ctgcgctgct ccojggtcct cgcgaggcgc ccgccgccgc cgccgccttc gagtccggac

541
tojacctctc ggacgcggag cccgacgcgg gcgaggccac ggtaggtctg cgttagggtt

601
tgcggagaac ccgagagttt gctttagggt ctgcggcgga cccgagaacc tgcgcggggg

661
aaagtgtgtg tgctttaagc ttgtgtacgt gggatccaaa gttactgagc tcagtgcacg

721
ctgctttgga gaaaaatctt cttcttttta aatagaaagt tgttactaga gaggcaagca

781
agttacacga gtgaagggcc cggagaggtg cccagtgaga gatcccgaaa tctatttcag

841
actggtttcc tctggggcaa ccaaggggtc ttgaaccctg cccagtcagc ggggctctgg

901
agagtatgag ttcattttgg tcgggaaatg ctcgtttctt tccccagctg attcatggga

961
ctccaaacag attctgggac actggtgatc agtcaaccca gccttacttt cctggagtgt

1021
tcatagtctg cagagcacca ggcgcbgtga gcgactttag aaaaaaagtg tcagggactt

1081
tagtaaccag gctccagagc tttcagagtt cacttgaagt tggtcagact tgagatgtaa

1141
cgggagatta gagtcagtta gatcacaatc aagcaatgca aggcttgttt caactttata

1201
agctcttcat tcctaaaatc tggtcatgag atactgcaaa ctaagttttt ttttttcttg

1261
tttgggtttt ttgtttgttt tgttttcttt taaataagag gtgtttaatc ctttgcctga

1321
aaatgttgcc aaaatacttt tgaggcatcc tgattttgaa aaaggatttg tgtgtgttcc

1381
tacttcttac tggctcttcc aaaagagtat atctttatct aaaaagttca tacctgccat

1441
aaccatatag agtatgctta agagagttcc taaagaagtt atattcgaca tttcagttca

1501
aacacttgca gtaccccttg ctggaactat actgoggtag tttatttcaa ctggtggcaa

1561
gtggagaggt acctgtggtg tgttacagtc aactttaatt tgactgttga ttaacacata

1621
cacaatgtgt agaaaatagc cttatatttt gaaatatttt atttatattt atattttgaa

1681
atacacttaa agattgagaa gactaatttt tggaaatcaa actacctttg catttaaatt

1741
ttgggaaaac attaaaatgt tggaatgtgt aataatttaa tataggggtt aaaggaatgc

1801
ctcttgagta aaaacaatat acatgaaata gaacagactg cattctgtga atcacaaaaa

1861
taattttcag tgcctatact tacattgccg taactatagt gatgaaaata tctttctgtt

1921
cttaaatacc gcagaaatgt aataatcggc tcaataacgc ttctgataat ttgagtcctt

1981
gattttgcag tacctatttg ctatttctgc aaagtcaaaa ctagtaaaag tatgatttag

2041
taaggcaaca tctctgtatt ggttacggtc acttactttg gtttacagta agaaaatgtg

2101
cagtagagag taaaatgaga aacattccct gataagccaa tagcctgtat gagagtcact

2161
cactgcbjgg tgagtctaga attaatgtac cttgagtgtg tgtgtgtgtg tgtttacgtg

2221
bittatgtat aggtatggga ttggaggatt aaaaaagtta acttattttt aactttcaaa

2281
agtgtcttcg ttggtgatgt aaaatttgcc attggtgata tggcaaattt taccattgct

2341
gtgaaaatca ctatgcattt tbitttgcaa atgtcgcttt tcatatttaa ccatttttat

2401
attctgtatg gtgaatatgg gttagtattc tgcatgtgat gtgggttcct ttcctatgtg

2461
atgaaacatc atttcccata tgaaacatca tctctgagtt ccatagacca caaagcagta

2521
tttcattgct ccattaaagt gtcgttcccc agtgggtgaa tagagccttg acagggcatg

2581
tgtcattaat gcattcagtg aaactgctgt gtccttgcta tgaaacatgt cacacaactg

2641
ccaagaaact gatatgaaga ctctatgtct ctccctagtg gcctgtacaa gcaccacatt

2701
tagatttaag cactagagaa gaactgggga gaaatcaatt gttaattttc tataactaca

2761
tgaaccccaa gaaaatattt cagaaggtaa acagaagatg ctaaatatct ataatcccaa

2821
tagatgcaat gttttcataa ctttcaccta ggaacttttt taatatttaa aaaatcaaaa

2881
atagcacaca aactatgaac caaggttagc catccagccc ttcagcccac ccgtaaagcc

2941
atgcaaaaga ttgtaggtaa aaatcacaaa tagaatgaag atctccttat tcctcgactt

3001
atatttgcat ttactggatt cctatttcta gttatttgtg gttgcatgac ttactgaaaa

3061
gtcttaaaat gtttctctga aggatgttaa cacaaacaag acagtgtcaa aaaagtaagg

3121
caggcaaaag taaaattaac tggacatgat gggaacaaaa gagaatagca agtctgaagc

3181
tgttctattt acaatttttc ttatagtata tgattatgtt tgtcaacatc tactcttata

3241
agagatttct gacattcctc tgagtgatgc tacttatatg aggttttaga tatagaaagt

3301
tcaattcatc tttcattttg atttccactc cattatagtc ttctgaacta tgaatatctg

3361
attgatagct atttattcac aagacagtta tcaaaattgc ttcatagaaa gcagttaatt

3421
actgatctta gtggcatatg tctaagaccc gtagatctct aatcctgtcc ttttcagttg

3481
agttgagaaa gacggagggt agtggattta gatttcattt tggacttcca gttctggttc

3541
cggttcctct tgagaggaag gtcctggcct cctagttatc tccatgtgtc caacccagaa

3601
tgcbgtttct cagctcttgc tggggttttc accaacagag gaactggcgt gagactaatg

3661
aaggtttccc gaatccctgg gactgtgctt gcctgcttgc ctttggcagt cctggggttg

3721
ttattgagag taggagttta taatcattat ctgtgatgtt cataacgtgt gttaagcact

3781
tcgcaaagag ctttgcaagt tagttttgtt tttcactaca cctccataat atggacatta

3841
ttttatttca ttaaggatga tgaacccaag atctgaatga cttaaccagg aaaaagaata

3901
gatgtttttt tccttttttt cttttaaaaa aagttttatg gcatatacca acagtccccg

3961
acttagaatg gttctattta ggacttttgg actttacaat ggtgcaaagt cgatagacat

4021
tcagtagaaa ccatacttca aggtttgaat tttgatottt toctgggcta ataatatgca

4081
gtaaaatact ttctctggat gctggacaat ggaagtgagc tgtgaccagt cagccatgtg

4141
atcgtgagag taaacaacag gtactctact gtatattaaa tatattttca actcaggagg

4201
aatttgtcag gatgtagccc catcgtaaat cgagaagcat gtatgtttta gagaaatgtg

4261
gtaatgggtt tgggcctttg ggcctgtgat tcagactcct ttcagcccct ctgctggtct

4321
cctttggcac actatagcag cgtgcaggaa ggcagagaaa agcactgcgt gtgactttgc

4381
agttaggggc accttgttgc atttatttag gtcctaattc cccacaacgg gacaaacgga

4441
aataaaccca gactttcttc caggctttac cacatggtgt tcgtttgact aaagataaat

4501
tataaatgac ctaatccatg gtaatattat aagaacgact gcttaactgg aggcttaaca

4561
agattttctg acaaacggtt tttcaaagtt gtgctcaagt aacttcagtg aaagattgtg

4621
attttacctc tgccaaatga cctttcacaa ataagtggat ttggaaagaa caaatttaag

4681
ttggcagaag cgttatactt cctctgactt ctgagcatat attgtttcac ctttcaccag

4741
ttacattatt ccttgtagat gtgcatttta taaatactat atgggtctac cttttgttac

4801
aaacacatat ttgtatgtac agatttgtat aaattgtgga ttaagttatc attgattttt

4861
ctcattagaa aaaacagata tagcagagaa ctttaaacaa ggagagatgc tgatgagttt

4921
gagttatagt gtaattataa aatttactat aaatatttta ggtttgtgta attgtttttc

4981
tgaaacttac tagtgtaaat ttttggggtg gcttctttcc toggttgatt aatttttttt

5041
ttcagagttt atgtttaacc atgagaaagc agagactgtt tttatttaat ttgctttatt

5101
gggcatccat catggaatta atcaaattgt acattaaatg ctttgtcagt ggattagtac

5161
tgtttcctta tactgctcgc gccctagtgg ctttcaggtg ttaggagtta tccacgatag

5221
ttttttttcc aattttgaaa tccaaaaact cattttcttt ttctttcttt cctttttttt

5281
tttttttttg agacagggtc atgctctatt gcccaggctg gagtgcagtg gcatgatgtt

5341
ggctcactgc aacctctgcc tcgtgggttc aagcgattct cgtgcctcag cctcccaagt

5401
agctggaatt acaggcatgt gccactagag caggctaatt tttgtatttt tcatagagag

5461
agggttttgt cttgtaggcg aagcbggttt caaactcctg acttcaggtg atccacttga

5521
tctcctaaag tgctgggatt acaggcatga gccactgcgc ccggccccaa aagctaattt

5581
tcttaaatta tttggtgcta taatcctgat ctgaactgac ataaggctat ttatagtcat

5641
tattatctaa tttaaatatt tctaatcttc actgggaaaa tagtaatgta tttatttaca

5701
tgatgctgcc atcagtcctg cttgtttttg gggtgtgagt attaatatgt ctatgcactt

5761
ggtttccaga aaaattccag gttcagagac tcttgcagtc tccaggcatt ttggataagc

5821
agatggattg tagccctgtt ccacaggcct tcctccattg ctttattgcc ttggggctgc

5881
ctggaagagg cagggaaagg taatccagga attcaagaaa gaagccatgt ggatgctcct

5941
aattcctttt tacccattag taccaggttt atttgctctt taatctactt caactcatgt

6001
taatcagttc ttactagtgg cagcttcagt tctaagcagg aaattacagt tcagtgtgtg

6061
atgcaaaaaa tgtagagtga gtgatcttgt ctataacaag cttataatca ttttggagaa

6121
aataaattta ctcattaaaa atactacaag tgaattaaac tataaatcca gaccatgtaa

6181
gtggttttgt aagagagtct tgtgagttac caccagttgt tggctagcct tctgggagtt

6241
gcatgggcag gcctgggaaa ggtggaatga tatgagaccc aatgttaaaa atgagtagat

6301
gctaattaca gaaatggggg agagagggat gttttgaata ttgaagaatg acagcaaagt

6361
acagaggaag taaaggtcag ggatatttgg ggaactagaa gcaaaccctt tggtgcaaaa

6421
gtcaagagct ttaagggaaa ctgaagggag catggtggga agtgtgaaaa ccaaagagaa

6481
agtctgagtt tgagttgaaa gcagcaggag ccaatgaaga ttctttagtg gtatgctgaa

6541
agtgaggttt ttaaggagct taacctggca ttgttgcaca gaagtgtcta agaaagctga

6601
ccagaagctt ctcagaagct tctcagaagc cattttcaac tgcagggttt cttaaagtgt

6661
ctggcagtga ctctgccttt ctcattacag tggccaccca tatatggtat tcgaactcct

6721
ctatatgctc ctgattgctg gcgatgatag tggtgattac ttttgactta ctgtaggcac

6781
ccatcattgt gctatctgga tacatttaca aaagtataga aatagacatc tctgccatta

6841
tggtttgcat tccaaacgaa gcaagcagtg taaacagtgg tcatgcttag atacacatac

6901
acagaacccc ccacacacat attcatgcat acaccgctta atagttcttc agactgccaa

6961
gtgtgactta cgtgttcttt cttgcatggt taagaatttg tagacagttc attgaaatag

7021
aatatttaga caatcagaag tgtacaagat tagaatctct atatttgcac acacatttat

7081
ttgtaggtca gtgggcaatt gaaaaaaaag agaaggagag aaccctaaag tgtcctggaa

7141
attcctgctt tttaaaatct gctaaaaatg agaccagaaa ggtgggagtg gggatgtgag

7201
gaggtgggta aactaccaaa taaacaatat aaatactttg gcbgttctta taaaaggttt

7261
ttttaaatat ggtggaataa tttactcaaa ctcaagagat gccacctact agagaaagga

7321
catactgaaa gaggaaatat tcaaatgcac aactttgtgt aaaaggtaat acttacaagt

7381
ttaaaagact cacttctaaa gaagtttggc ttcaacctgt cctcatttgg acaggtggaa

7441
agatgtatat tttggggtag accagaaaga tgtggtttga cttctatagt tgaaaggttt

7501
ctatttagac atttattttg taatttaatt tacctaaaac ttcatcccta aattaccatt

7561
ttctcttact tttatgcaat agtaaagtat gcagtcataa gtgataaagg ctgggatcaa

7621
agctagctat tttgctaact gcagaaccta tgcactctgt ttacactgcc tgtgatagcg

7681
cctggaagaa ctcactgcca atatttctgc ttgtttcagt cacataactg ttgcttgtgt

7741
cagtgacgta acttgtttag agatgcagtg cagtggataa gagcacaggg tatggacatg

7801
cctttctgta ttcatgtcct gaggatgcct cttagtacct gtgtgacctt ggacaagtta

7861
cttagtttct ctctgcttct ttgtagcaca atgagtagat gctaattttt aatttttaat

7921
tttttctttt tcttbitgtc tgttttgtgt atttagttac tttatctttt tttttttttt

7981
tttttttttg agacagactc tggctctgta gcccaggctg gatggaatgc agtggtgcta

8041
tctcagctca ctgcaagctc cgcctcccag gttcacgcca ttctcctgcc tcagcctcct

8101
gagtagctgg aactacaggt gcccaccacc acacccagct aatttttttt ttatattttt

8161
ttagtagaga cggggtttga ccatgttagc cagaatggtc tcaatctcct gacctcgtga

8221
tctgcccgcc tojgcctccc aaagtgctgg gattacaggt gtgaaccacc acgcccagcc

8281
tagttacttt atccttttaa aagtcctctt ccaaaatgta gaatataatt aatgcctgct

8341
taatcaggtt gttttgagga taagaatgtg tatataggcc aggtgtggtg gctcacgtct

8401
gtaatcccag cactttggga gtctgagtca ggtagatcac ttgaacccag gagtttgaga

8461
ccagcctgag caacatgggg aaaaccctat ctctacaaaa aatagaaaaa ttaactgggc

8521
atggtgacac gtgcctgtat tcacagctac tctggaggct gaggtgagaa gatggcttga

8581
goccaggagg cggaggttgc agtgagtgag ctgagatcac cccactgcac tccagcctgg

8641
gcaacagagt gagactctgt ttcaaaaaaa aaaaaaaaaa aacagcatgt gcatacatat

8701
aaagcccttg gaaccatgat tggcatatag taagctttct gtaaatttgt gttaaataga

8761
tagtcttcat gatcagaaaa caaacaaaga atatagcatg taagtactat gtcctagaca

8821
tatgacataa ctgtgattct tcagcacctt gcaactaatt tattaaattt ttaaaattat

8881
aaattactga caattttccc aatttctaaa atatagcaag aggatataat actgatgttt

8941
gattttgaaa caggtgaagg aaatgcaggg tgtttaatca ttcagtgtct ggaggctaca

9001
tactgtagtt ctgcctataa tatgttccca cttcccctgg gtgccggggt ttgttcctct

9061
cctggagggc agcacaggtg tccatagacc acaccaaacc aaagaatctg ggatgatgct

9121
gtctccttat gtgcttcatt catacttagg tcatttggct gtaaaggatt ttggtacaca

9181
taagcttttt ataatgccat ataatttaat atgaactcat cttgaatata ttcagagcat

9241
atacattttc aagtttaaat gtttattaat gaaacatgct aatgttgcta ctttgatgtg

9301
taaatatctc atctatatta ttgccacaaa aaataaatat gcattctaaa tttacaatga

9361
aatcatcaca gaatacctaa aatatcaaca atttcactga ggaaaatata aagaaaactt

9421
aaggggagaa tgctatatgc cagagttaaa cttgtgtgaa tttgtttagg aaaatgtgat

9481
tgcactgttc ctaagggacc ctcttccaga atggtaacta gtacagcgtg tgctgtctga

9541
gatgtgcgga cactgggaca ctgggatgaa ttatggagta gatactttcc ttctctgaga

9601
gtaagctgat ttgcttgagt actctagttt attccaaata gttgattttg tttggtggtt

9661
ctctttgtca atttgccagt cagtgctgtg acttgcgtgg ttaccctgtg ctgaagacta

9721
cagtgcbjgg ggcattggag gcccgtgagc agacaggaaa aagggaggaa aaatcagtgg

9781
tggacacact tcccagctct tgaacagctg acagcatatt tttttgattc agtaacatcc

9841
agaaagtatt cacttcccta ggattccagt gcagatgtta gttggagtat tttagaactt

9901
ttgaccagat accacatttt taaacagaat tttttttctg actggaactg gaacaaagca

9961
ctaaacacta aatagaccct caggtagtat gtaagtacat taaaaattag ataatactat

10021
attattcatt cacatctcta tggagatact gtatcatctt tttaaaagca attttcgtat

10081
taatatttgt atttcagaat tagaattgta tgtaagcata taataaaatg aagctttata

10141
gttcagtgct attatgtttt cccaattata gaattcaaat taacatttta atgtgatttt

10201
cttcatagta atttttcatt gtcacactaa tttatttttc tctcaacttt tttttattta

10261
aaaatttttt ttttttttaa tttgagacag gcctcactct atttcccagg ctgcagtgca

10321
gtggcatgaa cgtggctcgt tgcagcctcc gcctcctgta ctcaagtgat ccacctacct

10381
cagcttccca agtagcbjgg atcacaggca cgtgccaccc cacccagcta ttttttaaaa

10441
ttttttgtag aaatgaggtc tcactaagtt gcccaggctg ctctcaaact cctgggctca

10501
agtgatctgc cttggcctcc caaagtgctg ggattacagg catgagccgc tgttccagcc

10561
taatttcttt ttctcttaca agtgctttgc ttacattttt attgttagaa acaggattca

10621
aataactgct tatttaatat tctttttatg tagaagaaac agtcttgaac ttgataatac

10681
ttttggttcc aacttgttaa aatattggaa aaggatgaaa catttgtgaa aataatcaga

10741
ccttggcact goggtagttg aggaagagtc atgcgtgtga gtgagtgcca ctctgagaca

10801
ggcagcactt tctcccttgt ggtaattgaa tagggtatgg gaagccgact acttaatctg

10861
cttcaggcaa gcagtgttca aagtttaacg ccottttact gaaatgacaa acataatcac

10921
cttacctaaa aggatgtgtg ggtaatgatt ttaccaaata gttcacttgg tgaacaatag

10981
tgaaaacagt tcaccttccc ttgtctttgt ttacaattaa atgagcccct ccaggtccct

11041
ccctgcccca agagtggatg aatttggcaa atcagactga aatgttaaag aaaatggtct

11101
tgactactct gttttaactg aagtgaccac acagctgcca tgaatcctgt gattgaattc

11161
ctataacctg taaaagggat tgttatttcc actcactcca aatttcttgg aagtagctag

11221
ttgatatcag ataccagatg cgaggctatt ttaaatcact gtgatttaat ttactataat

11281
atcattgcct acatggaata tttttaattc tttctttttg tttgtgtctg ttttgtgtat

11341
ttagttactt tatcctttta aaagtcctct tccaagttta tgttttgaaa aaagagaaca

11401
cttactgaga ttcatgtttg cttacaggtc atgacattta tgacttccct aaaaaacaaa

11461
ctgatccctt tgtctcagag ccaaatttta gttttaacat aatagtgatt cattgtttgt

11521
tctctctgag tcctagatct ctcttttaat tttggtgtct gtccatgcca aattagaatt

11581
ttattaaggc caaaattatt catgagtcat gaccatcaca cttaacaatt gggtaatttg

11641
aagctgcttc agatacacat taaagcaaat aatgatgtca taaattttaa tgcaatattt

11701
tttttccttt aatattggta gcagtgaagc ctgctctgtt agagaccaat tctgttttac

11761
tttagaaaaa tgtacctttg tgctcatgtc catgagagca cagtgtagtt attttattac

11821
tataatatag cacacagtga cacataactt agtaaattaa agattgaaaa tatttaaaat

11881
tggtgatttt ttgtgccatg ttgatttgac atttattctt ctatctgtct aaaactagga

11941
gcagtgctag tgtgacagcc tcaagtcatg ttaacacgac acacgtagaa gactgacgct

12001
cgggcttcct ctagtgcaaa acacctgaaa ttcaaatttt gcttttctgt gctattttcc

12061
taattaaatg tatccttgat gttgagttta actttattac acccctgtta aatatctgca

12121
atgtgttggg aaggaggagg acacatatgc ctgatttaaa tttaatataa ctgtatagat

12181
ataatttcat tttccattca atcattgaaa tgatataaat taatatatgt acagctaaaa

12241
ttaaatctgt gatgtcgaga tgaactccat gctgtccttg gtgcactgtg tattacacat

12301
gggtattaaa tgcgtgctta gtgcttagtg aatgggttag aaggagtttt tttttttttt

12361
ttttgagatg gagtctcgct ctgtcgccca ggctggagtg cagtggggta atctcggctc

12421
actgcaacct ccgcctcccg ggttcaagca attctccctg cttcagcctt ctgagtagct

12481
gggattacag gcacgcacca ccatgccagg ctaatttttg tattatttag tagagactgg

12541
gtttcaccct gttggccagg ctggtcttga acacctgacc tcaggtgacc tgcccgcctc

12601
tgcctcccaa agtgttggga ttacaggcgt gagccaccac acctggccta gaaaagagtt

12661
ttaatagata cccctgtaaa atgccaagca atcagttgcc attactaaga actgcaacaa

12721
gttccagtta aagatgtaca tgtttaagag ctgtcgttct ttaataaaat atgaccaaga

12781
tgtcttaaac atgggcttta atacatgtta ctgtgggttt cactccaact taatagcaca

12841
caaagttctg aagacacatg atttcactgg tggtacattc gcacattgtt ttctgtccat

12901
gtttaagttc attcttgtcc agaacagttt ctggttttct aagcctaacg tattaacatt

12961
tgagttaatt aaatcgatag ggagcctttt atcttttttt ttttcctatc tgggggcttt

13021
gctttcgcac tgacattagc agttcccttc ctatgtgcaa taggaaaatg tgcagtcatt

13081
ccaggagcat ggtctcctca ggaggttaaa agtgattgta acttagaggt taatgtttca

13141
ctccagagga aagtgtttca coccacttga tgatgtgocc ctgggtgctc acagaaagag

13201
tagtactctt ttttaaacca aaattttaga cacgtgttat gcaaatcttc tttataaatt

13261
acacattctt ttctttcctt ttattctttt actccagtat actattttgc aattaaaaca

13321
ttttaaactt cttccagaaa aaaacttctt ccaataactt cttacttcaa actactttta

13381
ctaatgacaa aataactatg tccatcacag tgaggaatta ttcattgttt ataccacctt

13441
gtattactta tataaatatc atcctataaa aaatactata tattgggact agattttctt

13501
aaatttaaat ttaaattctt ttggaaaatc aggttctatc agctctgttg tcttttcatc

13561
tctaattgta catcttccca ctattttgat ttatacatga tgttattata ttaggatagc

13621
tttgatttta atgtaatatt agctagtttt atggcttgaa aaacttagta catagactat

13681
attcataaat acagcactat acattctagc atatggcgtg tgcacttaat ctgaagaatt

13741
agacattttt tcctgttctg tgatgattga ttgattggtg gtgggggcag aaggtggcca

13801
gtctttggca acatgtaaaa ttttgttaaa attttgtcaa actgatttat tccattgcta

13861
aattttgaaa tcagcatttt tttaggggga atatctcgag tttatgagga cagaaagaaa

13921
tattcttaga aaattgagaa ggttttgtcc ctgtacatgc aaactagggg gtgtttagat

13981
cagagcaaat gtcttgcagc aggggttgac gccgggccat gtttagtcat caaagcatga

14041
cttctattct gggaatgtgg taattgagag gtaaatatta tttacaatag cccttataaa

14101
tctttagttg ttcaacaaaa taacttgcca tcagagttag atgatttagc taaaattatt

14161
taattgggtt attcctactt gatccaacat ttgattataa tatatgtagt agcgttaaat

14221
aatttgggat ttctggcctc tggctggctg ttgaagactt tttgttggtg gcggggggca

14281
tcctaaggaa caacttgccc tctactagca ttctttacta gaaaaagctc ctatttactt

14341
gttttttttt tcctaaatat gtgttttatt tccttttggc attgtctttc ttgctcccaa

14401
ttataattgt gagcaaatag caatcgaaat tctgtgtaac ttccagcaca gtttagtcat

14461
cagagcttgc cagcaagtat gtctattgtg aggaaactgc atttgccaca gctagaccat

14521
cagcaagtga agtcgtattg tcctctgttt tgtagttgtt ttttcctatt tatgctttac

14581
tctgattcaa gttcagcatc tcagtgatca taattgtggg gaaaaaaatt cattttgaac

14641
tataaacaga aaagatacca agttgttgta tttgaaagat tattttagaa tgtggttata

14701
ccttcaagta aaataagctg taaaataagc tgaagaacca tatatttagg cacattttga

14761
ctataaaata gatcctctac atataacaag aatagctttt tttttttttt tttttttttt

14821
tttttttgag acaaagtctt gctctgtcgc ccaggctgga gtgcagtggc acaatcttgg

14881
ctcactgcaa gctccacctc ctgggttcat gccattctcc tgccccagcc tcccgagtag

14941
cagggactac gggtgcccac caccatgccc agctaagttt ttgtattttt aatagagaca

15001
gggtttcaat gttaaccagg atggtctcga tctcctgacc ttgtgatccg cctgcctcgg

15061
cctcccaaag tgctgggatt acaggtgtga gccacggagc ctggcctata tataacaaga

15121
attgctttta tatgtctata tgtcacttca taatatttgt ttattattta gctagttatt

15181
gcctataagc cagtatttag gtattatata aaatctgagg aaaacagttc tataagattc

15241
agtaaaattc caattctata agattccaag atgtaaagtg ttttaggtat ttaaaagttt

15301
tatatagaca atagtgactc atttgttatg gtatatgaat atagacaaga acttagactg

15361
aagcaaaaaa taacaattag ttacatagct atttcaaagc ccatgcagta gttttttgtt

15421
tgtttgtttg agacggagtc tcgcbitctc ggccaggctg gagtgcagtg gtgcgatctc

15481
ggctcactgc aagctccgcc tcctgggttc aagccattgt cctgcctcag cctcctgagt

15541
agcbjggact acaggcgccc gccaccacgc cojgctaatt ttttgtattt ttttttagta

15601
gagatggggt ttcaccatgt tagccaggat ggtctggatc tcctgacctt gtgatccacc

15661
cacctojgcc tcccaaagtg ctgggattac aggcgtgagc taccgcaccc ggccagtagt

15721
ttttaatgtt cagtgaagtt aaaacatctc ccgtccagtt atgctgtgta ataaatatta

15781
aagcaggaga tattagaaca atacaacact tactgtgcta tttataattt aaaatattaa

15841
agataaataa tggaataact ataaatattg atactatgat aaaactttta gcatgtctaa

15901
gttgttcatt ttgatagata caaaaaacca aagccaagca aaataaaaca cacctaaaac

15961
tttatgaatg ttaacaattt tctatttttg ccataaatct ttggccgttg caccatattt

16021
tattgaataa aggacagttg ttaagctagg gcttggtcca ctgbitgtca gtatcaggat

16081
gtgatgattc ttttctgacc catattcttc tctctctttg gctttggttc tcttgtacga

16141
ctcttctgta ggtggccttg gccacacctg tgaaatatag ggcacagttg tgctgcttct

16201
actcattgtg aacttgatca tabittttgt attgtgcctc tcttcattgg ctccttttta

16261
ttttagtgta attcaaagtg ttaattggag gttttaaatg tagttttgac caaattgtgt

16321
ttgaggtcac atgtacccag tttaaaaaac gaagaaaaaa attcaactca cttcccagcg

16381
tcctttgcag ctaatgttgc cctcgaatag ttcttgctca taagagaaaa tctagcaggg

16441
atttatggga aaacttttgc ttttttttgc taaggcactg cttttcttct tgttccctta

16501
tttccttcca tggaaatcag aaaatgtttt ataattttaa aactttacct ttgtttctca

16561
aaataacact ttcagactta tgtaaagcaa gattttaata attaatatgt tgcctcgatt

16621
atggagtaac tttccaaagt tgtactatca tgatcttaat ttattgaccc ttagggttaa

16681
gataatttgt gtgtttataa cctaacattc tttgcttggc tgatagattc ctttaaaatg

16741
ttabitgttt atattttgta catactttaa gaagctttat tcaattgcca catttcaaat

16801
aaataaaggt tctttttttt ttggtaagcc tatacctttg tttcttctag cttttaaaag

16861
tgttaatagc gtgggaatga cccttgacca tctctgattg tttgggaaat ggtaactaga

16921
aagaactgag agaggacaaa cttggatgag aagtctcaga actgatagta aaaacaaatg

16981
caaacaagaa aatatattac gtacttcatt cagattaata agtaattaaa cacttgaact

17041
attcaaaaat ctagtttgag tctaggcttt tgcaagcctg aatttgtcat cataatcatc

17101
aaaattagaa attacgaaag aatgttaatt taaatttaaa acagctggaa atacaataca

17161
tggcctataa gcttatcttc tcatctgtca acaactgctt gcatatgtca catgaactgt

17221
tttaactgca attacaaaag tcaatggaat gtttagaggt gattcaaaaa atgtgattgg

17281
ctgacatata gagttatcct aagaaacagg ctgtccaaca caattttaaa tatactcaag

17341
ctcttttata ctgattaaga gtttcaagtt aaggttttgg gttaaaaaat caacatcaaa

17401
tgataaataa gaaatataat cttgtttaaa ttatttattc taatagttta tttatgaaca

17461
caacatattt ctctttcatt actttttttt tctcagttgt aaaattctag agctggagcc

17521
cataggccaa tccgtagtat atctgaaatg attaaaggtt ttatacttga caagccctct

17581
gtctgcaggt tacttgcttc tacttggagc agtggattta tcatcctcca ctccagggta

17641
aatatctaaa agtcacttct gccacgttat ttcccatctg gtagattgtt ataatacctg

17701
tgagtcagta ttatctgcac agtgtatttc ctotgctcaa ggcactttga ccatatgagg

17761
tgttcacatc tgatcaatcg ggctgaagct tgccctagtc tgaggctgga ccaattgatc

17821
tctaacgata ttcttacctg acaatctaga ggatacaaat caagatgttt caagtgcaga

17881
aagcaacagt aaagcataag ttcttttttt ttttttgcat tctttttttt tttattatta

17941
tactttaagt tttagggtac atgtgcacaa tgtgcaggtt agttacatat gtatacaagt

18001
gccatgctgg tgcgctgcac ccactaacaa gcatatgttc taatgtgtaa tatatcttca

18061
agacagtctg gaccatgaag tgtattttta cttattgagt gtatatggga ggatcatttt

18121
ataggattgg ttatattttt ccatttcttg attctttgat acttaaattt ttggtttcat

18181
attctcctct ttcacatgtt gtccccattt tacatatgca aagatagttg tttgccacaa

18241
aaataaacat ttaacagact ccaaacacat agactgtgta attagcataa cgaaataata

18301
gtggctgagt gacgagcaga agtgattcac tcatttggct ctgtggcttt caaagttatt

18361
aatgatgtta catattcttc tctattttat ttaaaaacta acactcataa agttaattct

18421
cataattttt gcbjggttta ataattcaaa atatgaatca aaatttttat ttattatgca

18481
gtttcattct attaaaatta tctgctaaat taatattaag tagtcctata gcatatatta

18541
tttaataatt gcaagtagtg acatatcata aataaactgt ataatatgta ttattgattc

18601
tgttattttt cctagcaatg cacagggaac cagtaaattt cacaagcaga gaatactaac

18661
ttgtcattta tttaatattc taaacaaatg aagccgcctc tataagtgaa ttttctggac

18721
ttctaaagat gagcattgtt gagtttaata actcaaattt ttattgtgtt aagtaaagta

18781
tattaaatat aacctcaccc taatgactca gctgtaatta aaaaagagtt cacgaccagc

18841
ctgggtaaca cggtgagacc ccatctctac aaaaataaaa aataaaaatg aaaattaaaa

18901
aaaattagcc aggcatggtg gcatataccc aagtactccg aaggccgagg gtggaggatc

18961
gctcaaacct aggagtccaa ggctgtagtg acctgtgata gtgccactgt actccagcct

19021
gggaaacaga gcaagaccct gtctcttaaa aaacaacaac aaacctacac atgaaaatta

19081
ttgctgcttc ccatcaattt tcagtgctat ctttatttaa cctctctact atttgccttc

19141
actttttaaa attttgcttt tattcttctt tctttggtct ccttctctaa aatttttccc

19201
ctgcttctgt ttttttgtat actaggaaga catttattat ttttataggt atgatcaaat

19261
tgtaaaataa gtttatttca ttctctggtg atttcactaa ctattttgag agtatcagtt

19321
aaaatgggat ttgtttgtgt gtaacaaaat ctaactgtag tggctaaagc aaattggagt

19381
ttatttttct ctagtaacta aaaggcccca gtgggcgttt aagggctggt accacatgga

19441
gcaacatcat atcatcaatg tccagactcc tgtgcttttt tcacttgatc atttttagag

19501
tttggccttc tgtgcttcat tcctcgtggt cacaacatgg ctgattgttg tgcagcttta

19561
tgtctgattt caaggaagaa agaatagtga gagaggaggt tgttgcctta acacattcaa

19621
accaaagcaa aagttttctc tgaaatcccc agtagatttg cccttacatc ttctcaggta

19681
gaagtgcatt tttgccattc ctggctgtaa gagaagccga taaagaaaat acatgcactt

19741
tctaacaata ttgaaattct tttcacaaag aaggaaagga gaatgaatgt actttgggta

19801
ggtatcgtgg tctgttttat gttgctgtaa atcacaaact ggatgattta taataaaaag

19861
aaattagttt tcctcacaat tctgaagact ggaaagtcca gggttgcagg gctgtgtctg

19921
gtgagggcct tcttactgtg tcttctcatg gtggaaggca tcacatcagg agagatttct

19981
ccagagtgca agaacaggtg gaactttata taacaaactc attcctgtga taaggagccc

20041
actcccaaga taataccatt aatccattca ggtgggcaga gcctcatgac ctaatcacct

20101
tctgaaggtc ccacctttca atgcttttgc attggggatt aaatttccaa cacatgaagt

20161
ttggggaaca cattcacgct gtagcaggag gcaaccacat ttgtgacatt gcgtcattgt

20221
actttctaga tttgttttct ccaggttgtt tgcaacgttg atgtactctt tgtataccca

20281
cctgaaagat taatgttact gaagtattgt gtttaagaaa gaaagatgaa tgctaccatg

20341
taagaccttt tgactgtcca aaagattaaa attccagttt ggagaggtag cacttacatg

20401
aaaaccttat aaaacatgag aacttaaact tgctaatttc attgtgtcaa atcgcataac

20461
agagaaagga aaaacttgaa ggccactcct cttgaaaaag tatttgagta gtgtcgattt

20521
cagtgtaaga ccaattaaat aatgtcaaat taagtaaata taacattaaa atattttctt

20581
taacatattg gtgttgattt cacttttact ctgtaatttt tgtgacattg gaaacaggaa

20641
atattcaaat tttgccttct tttggatcgt ttcctctccg tttcttaatg tgtaaaccgt

20701
aatagggctt tctgcagcca acgtgctcat tcttttcttt ctgttaggct gtgccttttc

20761
tgagaacagt tggtactgat ggagatttct gttctttttc ttcacacaag tgtcatatga

20821
aaattggggg atcagctatt ttcagatcac aggctcctct gataacagaa taccataatt

20881
ccaactttcc tgtgttgatt tgtagatccc acactgtgtg atcatgacaa acatctaagc

20941
ataagagggc gatgaatgat taaaatttat tcactcttcc cataaaacac ctggtacaga

21001
tgcagtgtgt tgtcctcaca gaggaaaaac agtggttcct ccttccaagt ggcgtgtcca

21061
cagcactggt accagataac aagaacctta gacttttctt gttgctgcag tgtgtctacc

21121
tgtgcctctc ttaagtgtct tacacgttac tcacagagaa agaaatacaa aaatggaaaa

21181
cataagctca caaaaatgca tttagtgcat ttatgatgtt aatggaaacc ttggatacag

21241
tcctctgtta tttccttact actcttgata ttttacaata ttgctttatt attcaaattc

21301
ataatcatat atgtgttaaa caattttttt tggtaagtag actgtgtatc aaacttaaga

21361
gggatttgac atggaaagac atttaaaaga tggcagaaaa cagctattat aagggcattt

21421
gaactttaga tattttccgt tggtcagttt ccatagatca tcatctgatt cactagggtt

21481
tggccagttt atattattta aattgtttcc cctgcaactg tagtattttc tttaatgttt

21541
tgaattattc ttaatgtgac ttgaataagg gtaattgtca catatgctga tgttttccca

21601
ttaggatgaa aatatttaga aaagctgtac tagcaaaaac caggttaact tgttttcaaa

21661
gtagaattta attattttat ttcaagcttt gattcctttt ttaaaaatta agtaaatgtc

21721
cttgagagca atacctttgt gtgtgtgtgt gtgtgtgtgt gtgtgtatca gttacttgca

21781
ccttcaattg aatgaaagac agtagtaggt tgtattatgg cagaggggta gaagaatgga

21841
cattctcatg ggtatctcaa aggtcaagtc agaattggat tccctgtgga tggaagagag

21901
gagtggagaa ggtgcttctc atgtggaaaa acaagaaaag tctatgacag gcctcagtgt

21961
ttgccagctg cagtggaatt ctcatagctt gtattgaact ctgtgtccta atcttctgaa

22021
accacctcaa gagagtatat attgctaaaa taggagctca gctatttttc aggggcagtg

22081
atccagagga cactataaca gaaatagata atttcaaagt cgaaaatata ttagatacta

22141
tttttattct ctatctggaa agtctgtata gaggctttat tctggtctgc tttctcagat

22201
aaatatccta ttcaggtcac tggaaataat atgtcaggtt ttaaaagaga cttcatatgt

22261
agccaaataa acctgctaag catatttaga aaatcatgct agtgactagt gtcttaaact

22321
gtttccacaa aaacaatgct gttaatagta ggatttaccc ttttgcattg gaaatgagtt

22381
gtcaaggtta aaaagatgag tagccagata ttcttgctaa acatgttttg agaagaaatt

22441
taataatata aagtttttgt taaatgtggc ctattaattt taaacaataa tactgactga

22501
agtcattagg tagctgtgga aagaagttag cctggttttt actaatgtag cttttctaaa

22561
tattttctgc ctaatgagaa aagagggata agatccaact acaattggaa gcttaaatat

22621
ttaatcaagt ttgcagaact actattaaga tcatatgtaa ctatcagata ttttttaatc

22681
tgaggacttc tttctagtaa atagaaattt cttcccaagc attataggaa tatgtcttat

22741
tgacttattt ttttggcatg ggttactagg aaataatatt ttcagggagt tcagggaccc

22801
agatttgatt cccagataat tcagattaac cttctttaat cattctattt tatgttatta

22861
ctggagagta cagggtaggt tgaaacagca taaactgcca aatcagaact ggatttgaat

22921
ttagtgatgg gcctcaggag ctgtatgacc ttaattctgt gagtcaggct ttctgagtca

22981
ggctgtgaac tgggcaaaat agtgtatacg ttacaacatt gtaacagagc tcatttaaag

23041
cattgtctca tgttagctac tgataaagca ttagttccca ctccagggcc tgttagaatt

23101
ctaactccat ccctgtgagt catgttcatg ctttcgtggt tctcatttga ggttttgtga

23161
ccaaaggccc cacagatgga ataaaattaa tctaaatagc catttattaa tgtaatatct

23221
gctagctaat tacatattta ttaaatataa ataacaaata gctccaagat accagtgacc

23281
tccatgttgc taaagccaac agttattaga acttctctgt tctgtgagct tttctgtgat

23341
ggtcacaggt gagaccgcaa gaggacacac aggagaggca caatgaaaca aagtttatta

23401
tactcatagg tcttagacag gaggtcaccg catgccacac agggtcacag ggtgtcttag

23461
tttgttcagc ctgctataac aaagtgtctt agactggata atttataaag aacagaaaat

23521
tcattgttca tagttctgga ggttgggaag tccaagatca aggagccagc agattgggca

23581
tctgctgagg gcccactctt catagatggt gccttgttgc acgtccccct cacatggtga

23641
taggggtaag gaggaagcag gctctcccaa gcctctttta taagggtacc aatttattct

23701
tgagggctcc accctcatga cctcatcatc tcccaaaggt ctggcctctt aataccaaaa

23761
cgcbjgggtt gatattttaa catgtgaatt ttggagggac attgacatta cagaccacag

23821
cacggggggt ggggggtggt tctccatgtg gcagaagaca ggaaagagga gagagcttat

23881
gccacagcct ttactggagt ttcagggtaa aggcaaggca gagtagagta gggtaaacag

23941
tttagaactg gctggtttga atactttcag taggctctaa ggtataggat taatccctag

24001
ttgcttgata cctgacagtg ggaaattaag gcagaggaat attgtctcct ggggtatata

24061
gccagataaa ggaggtatgg ctctggattg ggtaatttgc ataccaaagg tgttctccct

24121
gctgaggttt ttgctgtctg taaggattgg cagcccctgg agggccatct ctcccaagcc

24181
ataaactttt ttttaagatg tojaaatatc atagtactca gaaaaatttg aaatatatat

24241
atatatatat atatgtataa aacatcctct tacttggcag catttacaat gtttgatcat

24301
tatttttcag ctttgtcttc aatgcactca ttttacctca gtggtggtta ctccatccca

24361
ttctccactg ctggctactc tccttgaact tttaatgtcg aagtgttcag ggctcagccc

24421
actgtcctct attatttttc atttctattc actctcttag tgatttaacc cagtcccatg

24481
gttctagata tcttcatatc tgtatcttta gtccaaatct gtcttcttaa ctttaaaata

24541
taactagctg cotttgtcat ttccactcag atggctaaca gacacttcaa atttaaacat

24601
tcccagttga aatttttatc tctccgtttc tgatcaaatt tgctctagct ctacctatag

24661
ccttccctaa ctcagtcagt ggcaacaaat tgctccgagt tggtcaagtc aaaattcatg

24721
gtatcatcct tgacttcttt ctttcctacc ctacattcag actcatcagg gaatccaatc

24781
ctcttggctg tgtcttcaaa aatataacca gagtctaacc acttgctaca tctctgacct

24841
gagccaccat cgtcttccac ttggatcagg gcagcgttct gtttaccagt ctcactggtt

24901
cttatcttca cctccctaga gtgtattctc aactgagcag aaagaagaat ccttttagga

24961
tgtaagtcac attatattcc tctcctgtta tatgtaaggc cctagaatag ttccctactt

25021
cacaaaaagt aaaaaccaaa atctctatca agtaatagta gtcattgccc tggcagtgtt

25081
tcaattaaaa gagtttaacg actggttcat tttatagagg tgtggacagt gtcaaggaaa

25141
cagaaaagaa caaaagaaca tgaagcatcc aggtactatc aacagtggga agtcctaact

25201
accctagtcc tgcaggggca aggtgagcga atagtgctat cagccctgga aattgctggg

25261
cactgtagga gaggggctgt caatagaagc tctaactgta gagtgcacac acttctctca

25321
ctatggtgag gcaccataaa tgtggtgagg cagagggaga gtgaggagaa tgaatatcca

25381
acctattttt tcttcacatc ccagccaaat acttggcatt gttagtcttt tttattttag

25441
ctattgtggt ggtgatgtaa tagcatccca ttgtggtttt attttgcctt ttcatggaaa

25501
ctgatgaagt tggacatctt ttgacaagct tgttgcccat ttggatatcc tcttttataa

25561
aatgcctgtt taagtgtttt gttcattttt ctttttggtt gttttttttt tttttttttt

25621
ttagatttct acaattcctt tacatgattt ggttgccagg ctttttaaag ctgtgtgtat

25681
tgcagatatc ttcttccatc tcttactggt cttttttctt tctttctttc ttttttttta

25741
ctggccagat ttctttaatt ttaatgtaag gtgatttttt cttgtttttc ctctatgatt

25801
aatatttttt atgtcttgtt taagaaacat ttgtctatcc aatgttatga aaatagtctt

25861
gtagaagctt tattgctttt tcactttcag atttatattt acgatcaacc tggaattgat

25921
atttgtgtag tggggagggt agaaatcaag actagttatt tttaatttgg ataactaggt

25981
aacctagcat atttctctgc tgctctgtag cattaccctt gtaaataaat catgtctcta

26041
tacggtttct ttctggactc tgttttacga ttgtatgctc tctggcatta gtatcacact

26101
gcctgaaatt ctgaagttcc atagtatctt ttcttttcct tgtttttttt tttttttttg

26161
agacagagtg tcattctgtc acacaggctg aagtgcaata gtgcaataat ggctcaccac

26221
agccacaatc tctcagggtc cagcagtcct cccacctcag tctcctgagt acctgggact

26281
acaggtactc accactacac ttggctaatt ttbitgttct tctgtagaga taaggcttca

26341
ctatgttgcc cagactggcc ttgaactcct gggttcaatt gatcctcctg catcagcctc

26401
tgaaagtgct gggattatag ctgtgagcca ccatgcacag cttcattgta ccttaatatt

26461
tgacagaaat acctacagtt tgttctttaa tatcaccttg aatatagata ttgagattcc

26521
attgaatcta aaaattgatt tggggaaaac tgatatatta gcaataatgg gctttctatt

26581
ttggccttat agcatttatc ctattatata atcattttta agtttttctt tttgtgtaga

26641
gaccttgcat atcttccttt toggtaccta ggtatgagac attttggaag ctatggcaaa

26701
ggatatttgt ttttgcattt cattgtcttt ttttttctgt gtatagtatt ctaggttggc

26761
atttattttc tatattctaa agattttttt ccatattacc ctctgttttt tattacatcc

26821
actatcaatc ttattgttgc ttotttgaac aagaaatgat tttcactgtt agcatttaaa

26881
attctgtctt tggggccggg cacggtggct cactcctgta atcccagcac tttgggaggc

26941
caaggcaggg ggatcacgag gtcaggagat tgagaccatc ctggctaaca cggtgaaacc

27001
ccgtctctac taaaaataca aaaattagcc gggtgtggtg gojggcacct gtagtccagc

27061
tactojggag gctgaggcag gagaatggcg tgaacccagg aggcggaggt tacagtgagc

27121
cgagatcacg ccactgcact ccagcctggg cgacagagcg agactctgcc tcaaaaaaaa

27181
aaaaaaaaaa aaaaattctg tctttggatt tcagtagttc tattatggtg tagtatttta

27241
gatgtagctt tcttbitgtt taatctgttt gatgatcata gcaatttttg aatctacagc

27301
ttgatgcttt ttgttatctt ggaaaatcct agaaaactac ttctttaaat atgccttttt

27361
ctttatagtc tctatcctcc agttaaatat atattaaaca tttgcagtat ctgctctata

27421
tctctatgtc acttttccaa tcatctatgt ctattatgct tttttttttc tagttttctc

27481
tggatgtttt ctactgatct gtcttccagt tcactaatcc tttctttagc tctaatatta

27541
ttaattccat atattgagac ctattttcag ttattacatt ttacagttct caaatttctg

27601
ttttgtaaaa taaattctat tctttgctca aattcttcat cttcctttct gttttctcaa

27661
acatactagt tgtagtactt taacaatacc tatttctttt ttttgaggca gagtcttgct

27721
atgttgctga aggtggtctt gaatttctgg gctcaagaga tcctcccagt tcagcttcct

27781
gagtatacaa tacctatttt aatatcaagc acaactgaag tttcattttt attgtctatt

27841
ttttctattt ttttgttagt cttatttgtg gatatttttc ttatttgctg aaaacttttg

27901
attgaatgtt tgatgtttta tttaaaaatt ataactgtct agactatgca gttttgcctt

27961
tctagagagg attcagtgta tcctctggta atcagccaaa aggcagacag atcactccag

28021
ttccattaga atatgacatg gctagaagct tttctgaagc ctgbitgtat cagtctggta

28081
tggcctaccc actttccttg ggagttgtct ttcaggatac ccattcagag cctatgaatt

28141
tatgagattt tttttctttg gtgggttctg aacttcaatt tttgtaacct ctgcactatg

28201
agactgttgc atacattctt gtgcttttca gaagatattt gcttggcttc tttgcttctt

28261
accatggata atttgaaaac ttagtgcctc aaaaggaaaa ccttaagtat cagggaacct

28321
catttctctc ttgttttgtg taccctctgt ccgtgatctt agcccctcaa atctgactgc

28381
ctttaaaggc ccaaacttta atgttttgtc tctccagctc tgtgaaaatg ctggcagtct

28441
cacttttgtt aactctgttg ttttctgcct ggattttcag cctcttacct atccaaggac

28501
tatcatatta tattacccaa gggaaaatgt tgctctcata atgtctgctc acctctctta

28561
ctttatgttt ctgcccagga tcttggcaac tgaaagcttg gctgtctcta tggttatatc

28621
ttcaaatagg tgtttgttgc ttttcgtttc atctcatatt ttctagttgt tctcagtggg

28681
aacattgttt tgtcacaagc tattccatca tggtcagaag tggaagttgc taagtcaact

28741
accttgataa ttattgtgcc gttagtatgg cttagtgact aagggaacac atttttgttt

28801
ggataggcct ttggtttaaa ttcctcttac tatgtttgag ataccgttcc attgaaaact

28861
tagttttatc acctgtaatc agaaaaaaaa agaccttttt ttagaggact cttaggagga

28921
ttaattggaa aatattcacc taaagtactg attacaataa ccatcacata gtaaatttag

28981
taaatatgtc tcaaatgata cagaaacctt atggaacctg taaggttaaa tcatgcattt

29041
ctgaaagtag taataatatt tactttactt ccagtgggtt aatatgaacc aaattatttg

29101
aagatatttc tattaaatat tgattacgtg aaagaatata acatatactt aagatctata

29161
acaataaatg aatgccagtg taccgctact caagttaaaa ataaaatact accagtccca

29221
ttgagtttta tgtatatgta ttccttataa atatttcatt gagtttttgc ttttgaaatt

29281
tatgtaattg gaatgatgtt ctatgcacct ctttgcaact tgcattatta taacttgctt

29341
tatcttaata tcatctctgt gattcattca tgttaactat agtttttttt cattttctct

29401
tattttcaat gtggtgagat tatgttgtat aatatctccc aaatatgcat ttattattaa

29461
tagaaatggc gtgctttttg atctttcact tttggtcctt tttccttgga attgtatttg

29521
ggaattagtt gaagatgaat ttctctagag cagctttttg tttgcttgtg ctccgcacct

29581
gtggacacta taaatagaga ccactttcaa aggtattttt ggcttaagtc tgctcgaacc

29641
acacagatag tgttacttca gaccacaact aggatgagag ctttctcctg attatatccc

29701
aaggaggaga tttctttctt ccttttaccc agagcaaatg ttgagacagg caaatttcct

29761
tgcagtctcc ttctgtagat cagagttatt tttctagttt gcccttatat tgagaggaca

29821
ctatagattt gttctagctt aacttaggga actactatta gactctttaa gagagctctg

29881
ggctctgttg cctgttaaac tgtcaagttc aaagcccagg ttcaccagct ggagcaactg

29941
ttccagggtg aatatgactt agtgttgaat actctctgaa ttatttcact ttatttttgc

30001
acccctagga atactttacc ttcttaatag atctttatat gcagacacac atatgtttaa

30061
acatatggaa gtacatatgt gtgcatgtat gtagataaat agatagatgc actttttcag

30121
aaagagtctt ctaccgaact gttagaaaca gaaatgtctt aagtctgatt tgtgctgctg

30181
tgacagaata cctaaaactg ggtacatgat gaaaaataga aatctagttt tcacagttct

30241
agagattgaa acgttcaaga tcaagttgct ggcaggtcag gagcctggtg agggccccgt

30301
ctctgcttct aaggtggcgc tttgaaggct gcgtcctctg gaggggagga atgttgctcc

30361
tcacatggca gacggacaga agagcaaaga gatagaaccc atgatacatg aaagcccttt

30421
tgtaaaggca ttaaacccac caatctgggc aaaggcttca tgacctaatc acctcttaaa

30481
ggccccacct ccccccatat tcttacattg gcaattagaa ttcaacatga gttttggagg

30541
ggacattcaa actataccaa gaaataactg attcagtttt tataagaaat tttagaactg

30601
tccctaagac ctggtgagtt tcaggcctca tgttctgagc ctacatctga catcagctac

30661
catagtatcc gctgtgcagg cagagcctct tcagtcatag gtatggggtg aaacagattt

30721
ccacctcttc cctgagcttc gctggcacag aataaatgca ttctaaagaa aactgatacg

30781
tcagagacat ctgagcttac tcttaattgc tttcttacct ttctctgtct tgggccagat

30841
tttcttccag gctgatggct tcttccaact ctgaattcta gcactctctg ctgtttcatt

30901
ttgtattcca tgccttcgtc tcttctctga tcccttccat ctgcctgaaa gcacttcctt

30961
tttattattt ctgtgtccta taataataaa gttaacaaaa gtgttaagta tatgtttatt

31021
tttccaaggt tacataggca catgtataat gtagggaaac tggctgacaa tcagagacag

31081
aagacacata cacgtgggcc cacacacatt cgttcactgt tgtccttaat gcagtattca

31141
acattacaaa ttactgtaat cttaataaaa ctgcgacatt gttttccttg tttatttagg

31201
gagcaccttt aaaaatcatg tatttgctga tttattcatt cactattgtc cttaatgtag

31261
tattcaacat tccaaattcc tgtaatctta ataaaactgt gacatagttt ccttgtttct

31321
ttatttaggg agcatctata aaactcatta tttactcctc agaaaacttg catgggcata

31381
tagttatgaa ccagtttgaa tattatgatt ttatattcac aatattttta tacttatgat

31441
cctaggctaa ggatatttat attagaatgt tcgctgagga cttaaataag ttctcactga

31501
tacttacact gaatattatc tcaatgtact tgagagaaaa ggtattgcaa gtaaaggtaa

31561
atatatgagt acatcaattg tataatttaa ttttctcaca attttaggac aattttgtat

31621
aggatctata atcatatact tttttaaata ttcacttgct tttattaaat caatcacaag

31681
aaaatacaga acgttttccc cttccacttc tgaagtggag gaaatcactt caaattcatg

31741
ggatctttga actttgccca ttgggccaga cttgcagtat cataaacttc tttttcctac

31801
ctatgtatga ttttgccatg tgcgaaacaa tcattgctag taccacgagt gagtgatgat

31861
aagcttagaa tacatccagc taagatcagt gccatttgaa gctccctcaa tatcgcattt

31921
cttcggttct ttaaaaaaaa ttcattgttt tggagtcagc atattattaa tgaatggagt

31981
atttgagggg aataaatatg actttggcaa tatcacatgc atgggaaaaa ttggctagag

32041
aaagggctaa gtctttcatt ctgtgtttta gagaacagct ttagctcgta tgaaaaaatt

32101
ctggcataga tatgtgaggg ggagtgttgg ataagaaaag gaaagagaaa aagcttgctg

32161
tggagtggaa ttctcatcac atttctttct tacctactac tctggggaaa cttcagttac

32221
agggctgata aatatttatt aagaatatat agacagtata acctaaaaac attggaagat

32281
attttagcga ggcttgagtc agattaaatc taccaaccgc taaaagatgg ctttgcctag

32341
agaaattctt ttttctttgg gagcagctat tagggaaaag cctattgcct aatatcttaa

32401
ttgaaaccta tgcataaaat tcaattaaaa atggcctata ttttgaattg tttttcaagt

32461
tacagaagaa ctttaagatc tttgtaggta atttctaaaa agcataaata tcttaaaata

32521
tatatctgta ctatcaccat taaaacttac cattctttgc tctatatttt ccaaagctat

32581
attcagagaa aataaaacct attatttcat agcctgcttt aaaaatatct cttaaaatac

32641
gctatttttc atctcctgat ctatccctca agaatatgat tttaaaactg cattacctca

32701
tttcgactta tttgttttat gtcctccttg ttattaacta tttttaattt tttctgtgta

32761
aaaacactta tttctttaca tattttctct aaatttggaa gctatgcctt cgtcaatgat

32821
accatgttaa cattttaaat ttttaaaaat attttaatat attttattca aacagtccca

32881
ataattaaat ttatttcact ggcaaatgcg atataaacca attgctgcat ctctcctctc

32941
caaaaagcat gtcttgttct agtgatgtat ttggagatag aagacttaaa ttattttatt

33001
tttttttact ttttaaaaat gagaaatgaa aactojgcta tatgcatggt gtacactgtg

33061
acgttttgat tgaagtacat tgtggaatga ttaaatcaaa ctgattagca cattatcatc

33121
tcacatactt atcatttttt gtgatgagaa tgtttgaaat ctactctatt attatttacc

33181
atagtcacca tgagtatatt acatcttcag aaattatccc ttctgtctaa ttgaaactgt

33241
accctgtaca caacatctcc ccgttgacca ccccaccagt ccccgagccc ctggtatcca

33301
ccattctact ctctgcttct atcatttgat ttttttaaat ttctacattt aagcgtgatc

33361
atgcatattt gtctttttgt gcctggctta tattgctaag cataatgccc tttagtttta

33421
ttcatctttt tgcaaatggc cggatttcct tcttttttat ggttgaacaa agtacctttt

33481
ttccccccac tgtcccaaat atatgggctc aacccccaaa ttggcaggtc taagaagtct

33541
ttccaaaggg tagtctatta catttaattt ctaaacataa gttgaagaaa agaaaattta

33601
tcctgacagt tccaaagttc aataaaaagt atagtttttg agtttttact tcagtaaggt

33661
attattttag tttottagct tttcagaaag totcagtott ttcaatggga aactctctta

33721
gggcatttaa aatataattt gctaacaatg aacttttaga tgagtaatcg tggctgctat

33781
cactggccct ggatggcagt gggatgagct tgcaatgcca aggatacagc tgagcaaatg

33841
ccactggaag ctaaataaca tgaaagaaac cagggttttg ttgtttacaa tggccatgtg

33901
atggtatgag tacaggaaag ggctagaacc tgggcatctg aggagaaaaa gcattgacag

33961
catggatgta aatgacgact ggtatttgaa tgcaatgtgg ggccagaggt agacatcatg

34021
gaaaagtatc agactttgca tacaggacac aaactaaagt aatcactagg gttagaagag

34081
gagcccactt tctggagata ggttactcag agcaagaaat gcagcaagtc agaaagctgt

34141
cgatttggga agctacttat taatgtacct tacatcctcc ctgacaacaa tcgagattga

34201
taaccacatt taattcagtt ctagtcagta agacggaggt tttctagcac cagctgccaa

34261
gattaaaaaa tgtgcatgtc ctagctctgg gaagtgtctg gtatgattga tgcttggtac

34321
ttgttcatct aaatatgaat ttactactgg gaaagaaatt aaacttctag atattcattt

34381
ggtagatcgg tgaggtgact gaagtgtggc aaacctcaca atgattatga ataaacttta

34441
ttaagaaaaa ctgaggcaat taacttattt gttcttcaaa actgaggaaa tatttgtcct

34501
cacatatatg atagaatatt gtttgctgct ggtaaccaat ctttgctttc ttctactaac

34561
aacttgtttg tcaatatgtc ttatttctca ctctaataag actatgtcta aataacttct

34621
ctcctaaggg ttaaaaatac aaagaatttt cacacataac caagtaataa agaatgtata

34681
ttattgaatg aatgagtaat ttacaaaaga aagtgttgag aagtagaata cataatttca

34741
gatttatgaa atatgaaatt tcagattcag gatctgtcca gtggagttgt gtttttactt

34801
ttatggggat taagtcaaag gcagtatatt aaatataatg gaataatatt cccccaaaac

34861
atggtaaatc tatactttcc ctgaatataa attttccttt aggacaccaa atctttaatt

34921
aggttaatta taatttcagg tagattaaag aggactattt ctctttaaac ataaggataa

34981
ttatatgaga attaaatctg tgagaaagaa ttggaacctg aaaaagacaa tggagaaaac

35041
tagcagacgg tatgttcaac tagaagaaag agaatttaaa agttaaaccc aaggtggtga

35101
ataatcacaa aaattgttaa tgaagagcac tttttttttt ttgctgatgt tctttaaagt

35161
tttttagccc tggtaataca tatttagaat tattttagaa tttgattatc tatgactgta

35221
ccaatattat tgtgttagca gtatgagtct tgctttctat tattgaaatc gttgttaaca

35281
gatcaaatta cccattatag ttttatgctc tgtgcataca gtggcatgac ttagattaga

35341
agaggtggat aabittgttc tcatattgat attataagct tttatcacag atctagggac

35401
ctttgtcttc taattcttgt gtgtttatta ttgcttattc cattcaattg gcatgtaatt

35461
gaaatggaat tgaagacaag tacacatgtg tgttccttta tggcccctaa cattcactgt

35521
ttagttatat aggtctagat tatgaatggt gcctagaaaa aaaagtatga ataaggaata

35581
attaataatg aatacttatt tccatcacct gttaacatac tctgtccatt tattcctcat

35641
tttaccgtct acatttaagt tctcttttct agccaccaag cattattgtc tagctaccat

35701
ctactgagtg tttaatatat gtccagaatt gagcagagtg ctttgtatgt aattcatata

35761
accaatctag caaacatcct tgatttttca ttttacctag ttgcctaaac cttccagcaa

35821
tctattagga agtcaaaaag cttctcttcc tctgaaatat attccaaatc catccatttc

35881
acctgttatt cttctaggct aagcbgtcat catcctttgc tctggtgatt gcaatagaac

35941
ctaattgtcc tatctttttc ttgotttaca ccottaaaat ctaatctact tcttgaaatc

36001
agggtgtgtt tcattgtaaa tgagataata tcatttctac atcttaacct agcagtgact

36061
tctttccatc atatctggac taaaatccaa actctgtatg gatgataaga cctatcagaa

36121
ttggagtacg tttttttcat ccccatcaca tgccatgccc gttcttttca aaaggctacg

36181
gctctttctt gtctaacatg taagcacatt cttttcaaag agcctggaat gttcttccct

36241
agatgggcat gactggctct tttttgtgga ggtcccagct accaattcct taagggaatc

36301
tacccttcct tatctgttct aaagtagcca cccagtttct atcatgaccc tcagtttatt

36361
gtcatcaaca cttcattttc ttcatttatt gtttattcct taattgattc tacttcttta

36421
gtagaaattc cagaagcttt aaagtgtttt gttcatagct gaatgcccag aacctagact

36481
aatttttgac attcaaaaaa tagcttataa gcatttagta cattttatta aataagaaaa

36541
tagtatctcc tctaatctca gaatattata aatttatatt gttattatca cttaatagat

36601
ttaaaaagtc atgaatgtgg gagataagcc cagggttatc cagttatttc agtggcagag

36661
tcagaatttg agctcatgtg tttcagacct tagaacttta cctatagtct ttgatgtcta

36721
catcacatta tgctccctcc catgtaccaa attattctct taacttacta tatcaactaa

36781
tatatctata aaataatctc tggcatagga atatagcatt catataataa atcattactg

36841
taatgcgttg acaatgcatt acagtaaata atgcattact taacctgata cattattcag

36901
ctgtttagat gagtcatcaa cctaaaaata tctgactggc tgtacagtaa tgtggtaata

36961
cattcatcat agagaaatta acgtatgggt tgaatattca tagtgatatg aatacaaata

37021
tgbitatcag taggattatg gatgtatgat agtttagtat ttacctagca tgtcaatgga

37081
tgataacaat tatctgcaaa tatttctgag tgttttaatt tgggtttccc tagaagtaga

37141
ctttgagaca gggaattgag gcaaggagtc tatctgggag gcaatcccag ggcactttgg

37201
caggaaaatg gtaaaatgag acaggatggg agaggaccca ataaatggta tgttatcaag

37261
cgagctatcg ttatgggtat ctggagttta attctacagg ggactctatg aaacagtgta

37321
gaacacacaa ctcagactta tcctgaccaa gatgcaaggg agcbjggtat ttatacaaaa

37381
agtcttgtta aactttggct tagggctgct ctggggagca taattacttg tctcctgtct

37441
gctgtaagtg ggcagcatgg gttctggcag taagagcaaa aactcaggga ataaagtgga

37501
gatgataaca gttgaaagtt ggactggtat ctactgaaat actgagacca tggacagctc

37561
gcaggctatt aacaaggtct tctaaactac tcatatatgc atggtaatct gcatgcattt

37621
ctgaatgtat acatctatac gaattggaac caacagatga aagtaactac atgaaaactg

37681
tgaaatatag aaattactta cctgtaatag gacagataga atatacagac aatgctctta

37741
agttcatggg tttctatttg aatgtatatg ttggtgcaga ccctgtgaca atctgtattt

37801
tcaggaattg taggtatatt tgagaaagtt atatttttat gtaatatata acagttctct

37861
ttaggactta tcagtggata tcctaagaaa cttttaaata ttttcctatg tttattcatc

37921
ccacttcaca ctggtataga tagatagttt tttgataact caaatctacc tgtggtaagc

37981
agaataatgg cccccaaaga tgtccacaac ctactccctg gaacctgtgg acttgttacc

38041
tacatggcag aaggggtttt gcaggtgtgg ttaaattaag gatcttgaga tggaaagatt

38101
atgatcctgg attatctaca tggttccagt gtctttacag gctctttata agtgaaagag

38161
agaggatgtg gagtcagatt cagaatggtg tgatgtgaaa aagactcatc tggtcattga

38221
tggctttgaa tgtggaagga agccatgagc caaggagagc atggagcttc tagaagctag

38281
aaaagggaag aaagtgtatt cttctccaga gccccttaca ggctttgcca gacaccttga

38341
tcgtagccca gtgaaaacca ttttggacat ttcacctgca aagctgtaaa aaaaaatgca

38401
tttctaatgt tttaagcaac taaacttgta gtactttaca ccagcagcaa tgagaaacta

38461
atgagctacc taataaacac agaggtaaag tcacctcaag taaaaaaaaa aaaaacaagt

38521
taagacctat gttttaaagg tcatagcagt atttccactg tccgtatgtc actgcagtga

38581
taaatgctgt gttttgacca ttgaaagaat tojaaattcg agtaagcaaa actaagttgg

38641
aattctgcct aattactctc tatttaacct cagataactt ttaatttctc tttgctttat

38701
gttcatcatc tggaatatgg ttacagtaat aatattctga cttccctcat gagttcattg

38761
taagtattaa tttgaataac ctaggcgaaa ggacgttgta gtctgcaaca tagtacatgc

38821
aattttattt ggctttgtta gcaaataata gtgctaaaag aaatcagata tccaaaagac

38881
ataaattaaa ccacataatc ctagtcaatt tgtagatttc tgagtatttc tgtatcaaac

38941
tggcaagtat atgctatatt tatgatgagt aagtcataac agttaaaaga ttgactatta

39001
attgagagta aaaattgtcc ttgttattgt cttatgcatt ttaatttgca ttttctgtgc

39061
cttaaataga aatattttaa aacaattcat gtatgcagga ataaaagcac tttagtggac

39121
tattaaatgg taaacttctc cacatcattc atgagggagg agttataaaa ctgttctaac

39181
tctcaatttc ctaaaacttt ggtaaaataa tattctatct catattctcc cttctgtatg

39241
tctttatgtt tgcaaagatt ctttggggca cagaaataaa caaatcatcc ctatgaaagg

39301
gtcatcgtag ctgccagtga ccaaaagagc tgcctgctga gcagtttcat actgttactc

39361
cagctgccat ggactcatgc gtgaggaatt cacacagcta atcaattcca taaggtgcag

39421
ttgctggctt ctctcttctt aagcctgtac ataaggaatt ggcacttgag tgtttcatcc

39481
tgtggactct acatcattcc ttcacaccct ctgccatttc ctggccctcc ccaaaataga

39541
cccaaagcaa aacaataata aacaatttgc tgtttgattt ttagtcagca ctaccattca

39601
ccagccctta agaatgccac agcagctgcc tgtcactgac bitttcagca ggatcaggct

39661
agaggtagga gaggcggggc aaaatttctc ctccttgtag gttttagtta attgctgtca

39721
atgacaacta gcagttgtgc acctgtttcc atgcatttag tttctaccct ccatcaataa

39781
attctaacaa ttatttattg aacatattct atagttttgg tccttaaaat aacatctgat

39841
tataggtact gttgttatca aatgaggaag cagacttcac aaatagcaac tgggccacaa

39901
atcttgctac caagtgtcct agccagtggt cttggaagtc taggctcttt ccctatagcc

39961
cccctgattt tattagccaa gttctaattc taacatggga aagtcctatt tcttagttat

40021
gtgtgatgta acttagattt gtgtgtaagt tattatttct tagttttgtg tgatataact

40081
tacattatca tgtacatgtg cacatttaca tcttacatgg gaaattttaa tcagaggatg

40141
tcttcatctt tgcgtcacta ctgaattgac taaagactca ctcaaagaca tttccgtttt

40201
aatagtgaag agaaggaagt gattctcttt gcatcttatc ccttcatcct acaggcattg

40261
tgctcctact gaacactgaa gagtagtttt gttggcagta accttagaac gtttggagtc

40321
aaaagttgtt gtctctatta cactcagatt gtagaaagtc agcaggccat tcggagtgcc

40381
aatatgagct atgtaaaagt catctcaaga ctggaggaag agtgactctt gaggccttta

40441
ttttccatat aaattgtgcc ctctgtttcc tagcaccttt caggatccgg ggcagcctgt

40501
ctgccatttt ccacttgttt agggctttaa aatcgtaaag aacttcatta actccatgaa

40561
ggccttcaat ttaatattga ggatactgga gtatttatca cagaaaagat acagctcaaa

40621
aattttaacg caatttcatg gaaaattaaa aaaataacta ttacattttg gtaagacttg

40681
tatactgaat ttttcagaat gtaagctaaa ttgggtttaa tcttatattt tataaaaaca

40741
aagaaatatg aaatttatcc atttattttt tttttcttta tgacatattc caaatataca

40801
gaggaggaca gagacctaaa agcctcaggg acccatggtg gggctctatc aaattctttc

40861
attttgcctt atgtttccag atattgttat gagaaaaaaa cttacaggta aattgaagac

40921
ccccatataa gccttcagaa atctcattcc ccttcctcca ccaagttaac caatattctg

40981
aatttagtat ttatattttt atgctttttt tttacgttta cacatatcat tgatctatcc

41041
aactttttgt aaattatgtt gtgctgaaca tacattcttc aacatgttat tttctgtttt

41101
bitttatgtt ttattttagg gattaagcct tgttgatgcc tatagcttta atatatatgt

41161
agaaatctgt tgtatgaccc atgggttagc aattctctgg taaaggatat tccattttct

41221
tcaaacattt tgctgctgca attagtactg tagtgaacat tttgatgttt ccttataaaa

41281
agaatggtgg tctttttagt ttgtaggaat tctttgatca ttctattaat cctttgtcaa

41341
ttatgtggtt gaaatgcctt gaattttcaa atttatttgt atgaaaatac tgacagtagt

41401
cccttatgat ttttgccatc cattctataa agagctattc gcgtttcaat tctaaaattc

41461
tttgtaagtt ttctctttca ttcttggaag actgttbitt tactctttag tctcttcaaa

41521
gaattttgtt tggttttttg gctctctcta tttctgtgtt tatatttcac tattttatac

41581
tgttgctttg attaaatcct tccttttaga ttgtttaagt acattttcat tctttttcta

41641
acttcttgag ttgaattacc ttaaatttat tattctcagt cttatagttt ttaataaatg

41701
tatttcattt attaaataaa tgtatccatt tctcttttaa cttcttccca caagtttgga

41761
aaagtattcc ttttattgta aagttctggt tctctttctt ttttttcttt ttgtcctatt

41821
gggatttcct gttataaccc atgggctact gaagttttca aacgtataga aattttttgc

41881
agaaagtttt tgcagtatct attaattaac gatttctatt gtaacatcat ggtaaaaaaa

41941
cattggttct gtaagatacc aattctttga aattgtttgt gatcttttgg aacccagctg

42001
gtggtcagtt ttcataaata gtttttgtgt atctgaaaaa gatgtcaatc cagacaggat

42061
tttatatgta tacctatgag aagaaacttg ttaaatttat gttagatctt ttctatttta

42121
ctaaattcct gcttcccctg aagggtttag gtatgcaagt cctttagaaa tctaaaggta

42181
gtaatgttag gtttataatt gaaatggctt ctcagtggac tctacgtctt ttactgtatt

42241
gtgaaccctt tgatgcattg ttttacattt ttttcttact ggcattagta ttactacata

42301
tataaatttt tttcaagtta gtatctatat agtatatttt cttcagtctc tattttaaac

42361
tttcaaaaca aatatagttt tgttttaggt tattcttgta atcatcatgt agttttataa

42421
aaatctaatt tgattatcac taatatgtga gtttgataaa tccacatagt cataattact

42481
gatatgtcac aacacagtaa gggcbgtggt cttcatttat ctgaacaact gctttacatt

42541
tagtttcaga gatcggagta ataatgaacc tttctgcatg tacccagtgt tatgactcct

42601
gtaaggatta atttaaaaat gttcaatatt tattttcctt ttggattttg ctgaaaattt

42661
aattttagaa ataaaaaaaa tctctagttc tttcaaattt tccatgaatt gaagattgtt

42721
taccgatcta tttttttaat actgcatttt ggcataattt tttaataaat gtttacactg

42781
taattttcag taattcagtg taaagctaac aggttttttt caaagatgaa gagacacaat

42841
atgttataga atatagtaca tggtgggaca gttaagtagg ggttctggag tttatttttg

42901
cttctgctac ttaactatgt tattacaaag aaaaaaatca tgtaagagac tccgccaaat

42961
tctcttctgt ataacaagag ggagtgacat actatctcaa tttcagtttt catatttaat

43021
gactcacaat tggatttttg gtatatattt gaccactttc taagatttta ttttttatgt

43081
tcttgaaaat tttatattct ataaatattt ttgtatacat atgtacctca cattcaaggt

43141
aagaaattct taagtaattg aactttgtgg ctataattaa atatatacac taatagatga

43201
cagaataaag aaaatatttt tattctgaga gcctaatttt aggtaatgaa aatcatttta

43261
tgggtaaata aagtacacat tttatagtgt gctaaaaaat acacaaaatt tgacatttaa

43321
aacaataaaa aatattaaat aacttggaat gaaaggagca tatcgaagta tttgtgaata

43381
aataatctca aattgatttt ttccaacact ataacatctc ttttctgttt aaaagaagtt

43441
taatagttgg ttcaatcttt tctttgagtt tgttttttat attttccaag cttttaattg

43501
tcagtggagg gagaggactt gagtgttttt aaggtttcca tcaacatcca ttctcctgta

43561
ttcattgtta ggccaaaagg actcaacatc tttgagtctt ccctatttga gaccaagtct

43621
atactcagct tctaatttca gctctagctt ccattcactc tcagtctttg ttagcattat

43681
ctaagtttag gttgagatta ttgcattatt gacttgcatt ataaacttct tctttcaaga

43741
ataatatgac cttttaatct tgttatatat gtttacccat catttacata aatttttatt

43801
ttatattcca tatggtttta ttccaacagt cttttgtagt taaatatttt atactcattc

43861
atcataaatc ttcaagtaat ttttagaaga attttgtaaa agtatatgac ttttttaaat

43921
tttgtgggta gactatatca ataaaatatt taaatatatt cagaaacttc ttttaaagtt

43981
catatcactt tactttggta aagagtttta gcaaaagctt ataattaaaa tatgcgacag

44041
tgctcacaga gcatttctga ttactatcag aaataggggt ttattctgga aagttgtttt

44101
cctgaaagtc ttaattgtaa aaagtgcagt ttaataccta ttatattctt atgtgtatat

44161
taatgccaaa ttaagcaatc ttcctccctt tctttcttcc ttctttcctt tcctctttcc

44221
ttcttttctt cgtttctata tttatgctgt atacgtacta cttgaaatat ccagacacta

44281
ctatttgttt aattcacaag ccatatctgg tgatatggat attattgttc ttgtttcata

44341
gttgaagaaa ctgaaacttt aatgaggttg gataagagcc acaagtatag cagattttat

44401
agtgtataac cctgcaaagc tcaaatttgg attgatatct ctgtttattc tagaaccctc

44461
ctctgtgtca ttctatgtca gtttgctttg ttgtttatta tggtaaagta atcattcttc

44521
acttcaacag ttatctgtga gttgattcta aaacatagaa aaattttgtt ttaaaataaa

44581
ttgtatgtat gtoitcacct aataatgggc ctatgtgggg tccacacaaa accagtttgc

44641
tgcagtcttg gcatagtgta aaattcccaa agtttttata tacatattga atgcctcaag

44701
gtatatttta aaagcccttg ctaatcccaa aggaattgtt ctaaaaattt gtttaaatga

44761
aatttttata tattttaata tttaaatttt aaataatatt tttaaaaatc ttaggctgaa

44821
ctttcagttt gtaattagca aagtaattat tatttgcccc aagccagctt cctcctattt

44881
cctgaccctc atttgtcttc cctccttata agatgcttaa tgaaagagaa cttgattttt

44941
gttcatttgt ttttgagaca gggtctggct ctgttgccca ggatagagtg cagtggcaca

45001
attgtagctc actgcagcct tgaacctggg ctcaagggat cctcctgcct cagtgtcctg

45061
agtagcbjgg actacaagct catggctaat gagcctggct aatttttaaa ttttttgtag

45121
agatgggggt ctcgctgtat tgoccaggat ggtottgaac toctaggctc aagcagtcct

45181
ccagcttggc ctcccaaagt actgggattg caggtgtgag gaccacgccc agccttgaaa

45241
cttgattgtt atttacatgg tgcacttaag aagcctaatc ttaccttctg acccagggtt

45301
tgcagtcaca gtccttagag tttttgaata aagactgtgc tatttctttt ttttaaaagg

45361
gatttgtttt tatctaattt atttctgcct ttatgtttac tcattattaa ttattcaaaa

45421
taagattggg atcatcattt atgtatgaat aactcaaatt agtttattgt aatacatagt

45481
cctggtgaag aagaacatat tcagttcatg ccttcaattt gcatttatct tgattagtgt

45541
ttaagtgcat ctcatttccc tatgcttctg ttttcatagc ttatataact acactgttag

45601
attttatgca tgatgtaaca ggatacaatc ccatgatata tttccatgat gtcaaagctt

45661
tgaattatgt aaataggaaa catgaagcaa aagcatacta cttattcatt atgcattgct

45721
atgojgcaga cgcacagtca agtgatgcta tttaatctcc ctatctgcat attcttaaag

45781
tgcatatctc tgtgatatcg aagcactcaa gcaatgagta aatttctgca tctggttaat

45841
aaattcagca aacaggagtt catcaacatc tggcatctgc cttattttac tggctttata

45901
tgaataactg atggatggcg acctttgata aatttagtgg ttgcttggaa ttttagtagg

45961
ggtttgatat tgtttgtgtg ctattgtgaa tttaatatgg caatcaactt tctcttggtt

46021
gctttactca tactagaaac cacagcatca accaatcaaa aggcbgttta gcatttggtg

46081
ttatcacata taccctaatt tgcacaactt tccaaaatgt aagtaccaag agagaagaca

46141
catcaataaa atataggaat tataaggaag aggaagaggt ttttaaaagt atattattat

46201
tcagcaaata atggaaactg gtgctcacaa actactaaat taagagggct tttttccttt

46261
aaaaattaat gcaatgatag tgcagaacac caaataaaaa ctgcatagcc aaggctctgg

46321
aaggttgctg gtggctcctg gacatcagtg ggatttcaca tctttctctc tgacatatca

46381
tttgttcatt tccagagaat gcccagctct gtgttttctt aaaaataagt ttagaattct

46441
cataaaggtg gacattattg gcctagcatg agttaatttt ctctacccct ggacctggac

46501
caatcatata tataagcaga gagcagaaag gtagcacaga ctgaggcaag gtgaggataa

46561
ggtatttttt gbitgtcaca gagacacctt gcttgtctca tttttgaaaa tgatgaaaac

46621
aaatggtgac taataaatag aaaatgctct gtggtattat cttctagtac taatgttttc

46681
ttcactgtcc ctggcctggt atctttcttg gcatacctca caaattactt gacttctgtt

46741
ttatgttgac ttcactcctt tacattacat tattgggaag ccctaggtct tagaaaacta

46801
tttcttaaac tgaattaaaa ttttgccctt gtacactggt actggctctg tcctctcagt

46861
aatagaaaag aagtcttcca tatgtccaca gccattattt gcaaaaagat atctctttct

46921
tcaggcttat gtttcccatg ctacatctct cttgttctct gaaccacact ttatacagcc

46981
tgactttcca tattctcact gttgctgtca tccccatctg atcattcccc tctgtcttaa

47041
aatgtgacaa ttacaactgg acataatact ccatctgtga tcttctcagg acagacccaa

47101
gcaggtccca gtatagtgtt agcaggacat cacatttttg gcttcagatg aacctgtaaa

47161
tacctaaagt acctggactt ttcccatgaa ttgttggtag gccaggatgt gtgccccatt

47221
agttggggac actttctagt gacagttcct ggaactctat ctggctattt ctctagtcag

47281
gcagtgaagg cagataaatc ctoggttcct ggcaggttca ggtggaacac gcagcacagt

47341
gtgcgctgtt gaatgagtgt tcccgagatc taatcacatg gaatgcctga ttgtcaaatg

47401
atgaacaaat aattcaggag atggacctgg gagttgaaaa tttttttaac aaaaaagaaa

47461
ttacatatat gcatttttaa caaaagtttt ataatcattg atatagtgat ggtagcacca

47521
gtagatattc aggcaagtaa ttatcaactg gatgacttat aaaggaattg ataaagcctc

47581
ccaagggatt caagaaaagg gtaaagcttg gaagtcccta aggataagtg gctgagatgt

47641
ttgattcagg acttcctgtc cttgaaacct tggtcagtta ctagcacgta ggacagtctc

47701
tattgtggac cagtaaaaag ctggttgtct ggagaattca gacagaaaag gtaaggctgg

47761
gacccagtta tcaaggctgc actacaacta gggcttgtaa aagttagggg attttggaat

47821
tagcgtagaa ataatgtaat atggtgtaag taacacaggc tttgtaatta gtgcaaaaat

47881
cataagcata tgggcttgag tcagtcttct ctttcctact tactggctgc ataccttttg

47941
tcagctattt aacctctctc taagcctcag cttcttcatt tataaaacaa attaatatta

48001
tctacactga agtattatag gagagatgat aatgtatttt ttaaaaacta gcacagaccc

48061
tggtcaacaa taataaacat actaataatt gttactatta taataaacgt gttgatatct

48121
ttttcttcat caatgacttt ataaaaatat tgggatggag atgccaaaat ctcctctgct

48181
aaatgccatc tttcatccta aggctataca ggaacaggcc ttgcctactg aactttgtag

48241
ctataggcct actacattgc ctcccacttg aaccctoggt tataaacgga atggagagtt

48301
acttttccat tcagaaaaga accttgatat ttcagaagga aaagttagcc ctggacactt

48361
gagcatttct aagaaaatag gttttttttt tctttttaaa ttgtgtacct gctgccctga

48421
attctctaga tgttctgagc actctgtata ttcttactca tagcttagta ataaattatg

48481
tttataaatt ggagactggt attgtataat ttagttcatt gaaataattt gatctggtga

48541
cttcatagcc agacagagtc aatggattca tataaatgag aatccagggt taatcaccat

48601
caaacatttt caacataaag tgacattttt ttccttagaa tgggattttt actacattca

48661
aattttacta atgctgtaaa catgaaaatt ttgagtcagg taatgaattt gagaatggat

48721
agctaatctt taaaaatcta gtaacaaatg tttctgggaa ttgtggctat tgttcccttt

48781
tggaatgatg accaacattt ttggaaatga aaatattgat aaatttgtgt ggacttaaat

48841
atggagtcca cacaagattg gggtcatagg acagaaacaa tatttgtttc acatttacat

48901
tgctgaggta ttatgaagag gttagaaagg tgatttttat ttagcttgca gaataaatat

48961
tttaaaatca cagaataaca tatactatta aatgcctaca tacatttata tccatatgaa

49021
taaaacagta gaagctgaaa tataaaataa catgccactg ctgctggaga gatttaagcc

49081
aattatctgc tatcctggag catcagacat atatatctat atctatctat aatattatat

49141
atttcataat ttatatattt atatatcggt ataatatatt gttttataca gattatatta

49201
ttatatgctg tttttcacca abittgttta catatattat acattattta tatccggtga

49261
ctacataatt gtgcatggta catcccgtct ctagtcagtt gtcatgacaa gagttttaat

49321
catttatgct tactttatga ttctattgta caatttttat tggacattat ttcagttttt

49381
attaattaac agggcatatc aaatacctcc atacacactt tattacagat ttttttgtcc

49441
caaatatttt tagcattttt ttaaatatga aaatagatag tttggaaaca agcttctatc

49501
atctactatt tcttcagtta tttgaatgca gatggcctat cacaggacac aagaagttga

49561
gaatgtgcta ggagaattgc cagcactgct caatacaggt gtttgcccag gtctaccttt

49621
tgactotctc acttgatctg ttottgtgct tctcactttc ctgggcagcc agtcccttac

49681
tgagtatttc tggccttcag tatctgcttc ttccggttcc tttgatgcag cacccacttg

49741
ggctcgcttc tgtagttcgc taaactcagt tgcttatcat tgtaatattt ccgtaatatc

49801
agaatgacta ctgtctcaac ttaggagaca tccacttgtc ttctccagca cctgactgag

49861
ttcttgccat ataaattttt gttgaataaa ttcaatgttt ggcttttcac atcatcataa

49921
acaagactta caccaacaat catgggggaa tttgaataaa attaagatta ggtctgactt

49981
ttgcaatttt acaacttaca agttagtgtt aagaaaatgt ataaagatgg tgatatgcca

50041
ttttgaaaca tattaagcat tttcatcttt agaacagcct tcaagagagt tattatgaaa

50101
cacatttaag cttaagaaag ctgagaatca gaatgataat taataattat ttgagggtgg

50161
atgaaaaagt aaagaacatt tacacagttt tagtgagaat gtaaattagt tcaatcctaa

50221
ggaaaacaat atgaaaattt ctcaaagaac taaaaataga actacagttt gacccagcaa

50281
ccccattact ggtatgoggg tggtactata taagaggaaa agaaacatcc tgtcaaacag

50341
acatctgcac tcatgtttat cgcagcacta tttttaatag caaagtcatg gaatcagcct

50401
aagttcctat cagojgggga ctggatacag aaaatgtggt acatacacac catggaatac

50461
tatgcgtccg taaaaggatg aaatgatgtg ctttgcagca acatggactc tgctggaggc

50521
cgttttccta agtgaattaa cacagaaaca gaaaatcaaa tacttcatgt tctcacttat

50581
acgggagcta aacagtggtc atgtaagcac ataaagatgg aaacagtaga cactggggac

50641
tccaaaatgg ggggaaagag ggaggagaac aagggttgta gaagccaaat tgaagcctga

50701
aacaatacac ctttgtaacc cacctgcaca tgtggcccct gaatctaaaa taaatcaaac

50761
aaaaaattaa caagcaaaca aaaaacagag gaactagggt ttgaattaat atttctgatc

50821
tgcatatcgc tattttcctc ttaaattatg tgcttaaata catgaagaag gaggaggaga

50881
aaaaaacaac ttaattagga gacttacttt aataatgtat catttataac ttttcttcca

50941
aaatctggtt acatgtcaag aaactgtata atgtgaatct ctctagttca cctttccttt

51001
cctttatgta gatcttggtt gcaattcaga ttttcttttt tctaatgaac agtacaatca

51061
gtaacagttg caccaaacat ttcaatttgc aatatacatg taatggtttt tcaagtgaag

51121
gttacatttt atcttttttt attatccata gaataatgtg ttttaggatg aaagagacac

51181
tgtgtgtgtg tactccgttt aaaattaaga tctgacggtc tgagacatca catacaaagc

51241
ataattcagt agctatctga cagtttccca attgctatga cactaaaaat aaaccaaacc

51301
agataaatca accccctaag tggactctct ggcctgaaat gttojggttt taatgtgcct

51361
gtggaatgtt ccaatataat tttcatcaat gttgattgtc cagctcacac agccctgggc

51421
actagagtga ttgacataa ccccgtcatt attccaacaa ttaaatcagc aggaattagc

51481
acaaacattt ttttcctgtt ccgtacacta aaaatgtttc catgctgcaa tgttaggatt

51541
taaatgtaac aaacataatc ttccctgtgt tgtataactt tccgatctac taagaaagcc

51601
taccaaaatg gagcatttgg tttaaaaata aatacctgga ctcttccatg tggcaacaaa

51661
caatacataa gagatattgg acaatgaaca attaattaca ttgataaaaa taattgatga

51721
attaagaatg taaatctaaa gatactttat attcctcttt ttggtttaac tttcaaatcc

51781
agaaagctct taacctggtt aactaatcga tgataacgtt atacaacaaa cttttgttga

51841
gtacttgcta ttcattcctt gaacgttatt tattgtaata aacgtgttaa ttgaggttct

51901
acatatataa aactgtttaa ggtgcaatga aacaaaaatc acctgaactt cggacaaatg

51961
tgatttttgt ctttgcttag gacgtttttg gaatatttac ttttgaaaat gtctccatga

52021
cctgtggcag tgttttcttc tgaatagtat aaatgacgat ggcaaatcta aaataagtta

52081
tttggagcca catctagaaa ataatgtgag tattccagtt attagggaag gctagatttg

52141
atcaaatata tatatagtta tatgtattct ctctctatat atagaatata tagttacata

52201
tgttctatat atagttatat atactctcta tatatagaat atatagttat atatactctc

52261
tatatataga atatatagtt atatatactc tatatactct atatagaata tatatataac

52321
tatatataga atatatataa ctatatataa atatatagtt atatataact atatatagaa

52381
tatatataac tatatataaa tatatagtta tatatattta tttataaata tagttatata

52441
tactctatat agatatatac tctatataga gaatatatag ttatatatat tctatatata

52501
tattctatat atagttatat attctatata tagatatata ttctatatat agaatatata

52561
gttatatata gttatatata ttctatatat ataacttcta tatatagtta tatattctat

52621
atatagaata tatatataga atatatgtat agaatatata gaatatataa tatatagtta

52681
tatatattct atatatcgaa tagttatata tattcgatat atcgaatata tagttatata

52741
tattcgatat atcgaatata tagttatata tattcgatat atcgaatata tagttatata

52801
tattctatag ccataatgcc tattagcctg gcatttagac ttgcaagtgt caacttatta

52861
cttaccttgt tttattttat ttctttaatg atctcaaaac cttcctctct cgatttcaat

52921
ctgtggtttg ttcccaccat ttgccgaggt ctagcatctt attctttgat tttctttttt

52981
cttttcttca acttttaagt tcaggggttc atgtgcagga tgtgtaggtt tgttacgtag

53041
gtaaatgtgt gccatggtgg tttgctgcac agatcatcct atcacatagg tattaaaccc

53101
agcatccatt aactattctt ccgatgcgtt ccctaccctc atacgctccc cccacaacag

53161
gccccagtgt gtgttgttcc ctcccatgtg tgcatgtgtt ctcatcattc agctcccact

53221
tataagtgag aacatgcagt gtttgctttt ctgctcctgc attagtttgc tcaggatgat

53281
ggcttccagc tccatccatg tccctacaaa ggacatgatc tcgttccttt ttatggctac

53341
atagttttcc atagtgtata tgtaccacat tctctttatc cagtctatca ttgatgggca

53401
atgattttgt aatataatga tttatattcc tttgggtata tacccagtaa tgggattgca

53461
gggtcaagtg gtatttctgc ctctaggtat ttggggaatc accacactgt ctttcagaat

53521
ggttaaacta attaatactc ccacaaacag tgtaaagggt tcctttttct ccacaacacc

53581
accagcatgt gttgtttttt gacttcttaa taatagccat tctgattgga ataagatggt

53641
atctcattgt ggttttgatt ttgcatttct ctaatgatca gtgatattga gcttttattt

53701
catatgtttg tcagctgcat gtatgtcttc ttttgagagg cagaaatacc attcgaccct

53761
gcaatcccat tactgggtat atacccaaag gaatataaat cattatatta taaaatcatt

53821
gcccatcaat gatagactgg ataaagagtc tctgttcatg ttctttgccc actttttaat

53881
gggatttttt tttcttgtaa atttaagttc cttgtagact ctggatatta gacttttgtc

53941
agatggatag attgcagaag ttttctccca ttctgtaggt tgtctgttaa ctccgatgat

54001
agtttctttt gctgtgaaga agctctttag tttaattaga tcccattcgt caatctttgc

54061
ttttgttgca atcgcttttg gcgtcttcgt catgaaatct ttgcctatgc ctgtgtcctc

54121
aatggtattg cctagattat cttctaggat ttttgtagtt ttgagtttta catttaaatc

54181
tttaatccat cttgagttaa tttttgcata tgatgtaagg aaagggtcaa gtttcaattt

54241
tctgcatgtg gctagccagt tctcccagca ccatttatta aatagggagt cctttctcta

54301
ttgtttattt ttgtcaggtt tgtcaaaagt cagatggttg taggtgtgtg gctttattcc

54361
tgggttctct gttctgttcc attggtctat gtgtctcttc ttgtaccagt atcctgctgt

54421
tttggttact gttgacttgt agtatagttt gaaatcaggt agtgtgatgc ctccagcttt

54481
gtgctttttg cttaggattg tcttggctat ctgggctctt ttttgattcc atatgaattt

54541
tttaaaagtt tttctaatgc tgtgaagaat accaatggta gtttaatgga aatagcattg

54601
aatctatcaa ttactttggg cagtatggcc attttcatga tattgattct tcctatccat

54661
gagcatgaaa tgcttttcca tttgcttgtg tcctctctga attttttatc agtggtttgt

54721
acttctcctt gaagaggtct ttcacttccc ttgttagctg tattagcatc ttattctttc

54781
aagaggacag tttgttcagt ttgtttaaat tattatcacc atcacaacca ttaaaccttt

54841
attcagcaac tgaagaatgt accacaatat ctctcatttg caagacatat tctgttcatc

54901
ttctgctttc tgcttctgta gcttataaag atatataaat atattttaaa cccaatttgt

54961
aattatatat gatgggaatt gaaaacgtgg gtgattttca aataatcact aaggaataaa

55021
atatgctaaa aataaattgt gaagaattga tatgattttc taaggatggc tttactggag

55081
aaaagcagtt atcctacaat agttaatata taactatttt tatgattatt ctgttcagaa

55141
tctgaattta tattattatt tggggccttt tttaatcaag tgaagaaagg tatattttct

55201
tttcaaactt tttattttga acattcataa attacatgaa cactaaaaga cataaattat

55261
ctttcaggaa acattgaata aattctggat tcttctatat tttattgatt tgtaaaacat

55321
ctcaaattta acatagaaat gttaaaaaga gattatatta taacgtttgt tggaaaatat

55381
gctatattta taatatttat tctgtattta tatattataa atatattcta tatttatata

55441
ttataaacat attctatata tattataaac atattctata tttattaaca tttaacatta

55501
atgttaataa atatagaata tttttcaaca aactttataa tataattccc tccttcaatg

55561
aactaatttt tatggtggtt tacatttctt tttcaatgtt ggtttacatt tgacgttagg

55621
atgtttatta gttaatacaa taaagtgggt ggtcttttca ttaatattat cagtcaggtt

55681
tgtaaatagt gtatgttttg tataaccact taaaatttat atactgatat atattttgtt

55741
taagaatact taaaataaaa acattagtta tcatttgttg aactggaagg atcattactt

55801
aaaaatccat ccttaaaatt aaaatgactt atgcttcact gtgtagtgca ttgataaata

55861
tttagtctat agttttttct attgctatgt gtttagccaa gaattgtttt taatttggtg

55921
aacagtacct tattaggaat atgaaaattt ttgaagcagt catgaaatat ttaacaatta

55981
attatttaac aaacaattat gcaaaattaa ttttactaaa gaaatatttt taaatcactg

56041
caagaaatat tttcattcaa atgagtactt acaaccaaga aagagtcttt tattttttaa

56101
atgtgtataa atttaaactt caaaatactt aaatcactta atgcctcaga gaaaatatct

56161
taatacttat gaagtgttac gtgtactaag cattatgtta aattctataa agacatcttt

56221
ttaaatcatc acaagaaatt acaaggcagg tgcatctatt atatttttta tagtagaact

56281
aattgaggca cagtgagagg aaatgatgta ctcaagttcc acaggtgata agtggtacag

56341
ctgagtaaaa ttccaagtct aaaagctagt ctcttaacta ttatatatcg gcctatatgc

56401
ataggccgac aagtagttat ttaaagttat ataaatcaag agaaaacact acaaaattta

56461
cctataggat atttatacaa aatatgggca ttttattagg aaagotttct agaaatatgg

56521
gggaacttta agaaacagtg aaattcaaag ctatcattgt ccaaaagcat gtggtcttct

56581
gtttttgcac tagtgactta ggtgcaaatt acttccaaga tttttctcct aattgagaag

56641
tactttttag gtctagattc catggaggag gtgggtcttc gaggtggggc ttcaaggtgg

56701
agatagtgtc ttttttctag catgtaatga ggtaaatttg cttttgaatg aacaggtgca

56761
cctatttcaa ttaaggcaaa ttagtttcca aaggctttgc tatttaagat attatagaag

56821
gctatttaaa tgtgccaatt tacataaaat acattttgaa agattacagg aaacaatttt

56881
atataattca ctgaaacaat ttcacagtcc tctcaaatga tgattttgaa aatgacctaa

56941
atggcaggca cctctttgaa gcagctggca tgatgttatg tggtcccatg gccccttaca

57001
ttttcaggtc aatggtaaat tctccagagt ccaacttcaa ccctgcagta ttctgttcaa

57061
aattgcccct gttcagaagc ctgcatatgt aacctcttac attttgtgtt tcacaatttc

57121
cattgaactc ttcctacaca ccagaatggg caaaaatagg aatttaattt ctgggaagat

57181
ttcctctaag agcctctgtc caaaacatcc agtgctgaaa caagaaaagg tggtcctggc

57241
atatatccac tagtaatttt tttgtcttct tcttttcttt cctgttttat gtgtgaatag

57301
tgaaacttat cggttcaaag accgatgagt cagaatgctg tcattttaca tccaaacagt

57361
ggaaatttaa attgttaaaa taaaaataca caatcactaa cattaccctg atgaaataat

57421
gataagcaaa gtagtcttaa attacaggct ataagtgctg gataaagaac aatattttaa

57481
aaatatctaa agtcatataa tgaacagaag acagatttcc atttatacct gaaagactgg

57541
ttttcagaaa ttataataga acatggggat ttaaaaattg tatttggatc atttatttta

57601
cagttagaaa gtgatgtagg aaggagttcc cagaggagat gaaacagatt gaaaacagca

57661
aaattccatg acagaggtgg cttgaaatag accctttttt caaagcaata actggcctct

57721
tcatcatcta tagatagcat ttttggcaaa atcagaaaca tttgctttgc cagtcattga

57781
aggtaaaaag aaaaaaaaaa tggctgaatg cttttaaatt acatttattt aatttctgct

57841
ttcatacaaa ggcataaaat tatcagttta aattttaaaa aatattatta taaaattaca

57901
tgcttagaag tctgttgatt gttttcccac agccatttta taactgaaac cctcaatttt

57961
ggatatgaat gtataataaa cgcacatgtt cattctaaac attttctttt caaatacttt

58021
tacattcctt taggtttcct aaagaaatgt aaattccttc tgccacttag tttttgctat

58081
ttttagcagt ttcttaaagt ctgcaaattc ctttcactca gtttttgcac ttagttcata

58141
atgacttcac atttgacatt gattgtccac aaaaggggtt atttttagtt tcaaaaggtg

58201
aacgttattt gttttagaaa ttctcgcgta tatttcttag tctaaagata ggttttctaa

58261
cataaaaatg tgatagtgta gtctgtttgc tgagcacttg tagtggaaca aactcagtgc

58321
taaattcttg gtttttaata actaatttat ttattacagt aactgctaaa tatgcttcaa

58381
attataaact atttgccaaa attacagata ataatataac caaacaccat gtggatttca

58441
cctaaactag aagtaacttg gtgactttct tatttaatct tttatttatt gtacttggcc

58501
atacttattg tatgtttatg tataaaaaca taaagcaata gaagttttta cagttattat

58561
actcactgtc ttataaatgg agaaactgag acccagagaa ttttagtaac ttattcaaag

58621
ttacctagct ggtgactaga agcaaaacac aaataagacc acagattact agttttgtca

58681
agatcttcaa cataatttaa tattgcbgtc aactcagagg tctcagaaga taaggtctta

58741
ccatctgaaa acaacaaaaa agaaatttca taaaatcctg tttgtaccaa gcaatttatt

58801
tctagaatga aagcaaaatt atttttttaa agttctttag attgctgaga aatcaagagc

58861
attagggttg tgtctcccct ttaaatttac cttttagttt ctttgggttt aagtttttag

58921
atgaaatttt aaattctatt tagctctcag tttatgtgta tttaaaattt agatttagga

58981
tctattcttt ttaataaggg tgaaattaca tatggagaaa tttactgttt atagcgagtt

59041
ttgacaacta gagttgtata accaccatcc ccacagtcaa gatacatcac ttctcccctt

59101
cccaaacata ttccctggtg acactttgtg gtcatactca ttctccgcct ctagcctttt

59161
acaatgactt ctgttactcc ccctgtagat ttgcctatta aagaatgtta tataaaggaa

59221
tcacacatca tgtagcattt tgaatctggc ttgctttact tgttttaatg catttgagat

59281
ttgttcctat tgtggcagat atcagtagta gtcttctttt cattgttgga tattccatta

59341
catgaatgta caatcacatt ttatccattt gcccagctaa agaacatttg ggtgttttca

59401
gttttcatta ttatgagtaa accctccata aacatattgc atacaaattt ttatgtgaac

59461
ataagttttt gtttcaccta aacagatact atacaggact gaaattttag taagtatatg

59521
tttaactttg tgagaaactg cccaactgtt tttgcaaagt ggctgtacag atttacattt

59581
tcaacagcaa catgtgagag ttccagttgc tgcacgtcct tgtgagcact tagggttgta

59641
tttttaattt tatccactct aatgggtgtg gagtggtgtc ttattaaggt tttaataagc

59701
atttctctaa tttaatgcat tatattactt ctttttgttg gtttgtaaac tgcttatctt

59761
ctttggtgag tttgatcaaa tcatttgtcc abitttgtgt ttttgattat atttcagata

59821
caagtcttta ccagttatgt gctttgtaaa tgttttctca ctgtttatca tttgtgtgtt

59881
ttatggaaag cagaatattt cgattttctg gaaatataat ttgtcacttt aaaaattatg

59941
taaattgcta ttggtattaa gtgtaagaaa actttgcttc atctatgatc acaaatattt

60001
tcttctgaaa aaaaagctct ctgaagagtt tttttttttc aatgaatgtg ttttctttct

60061
tctctccata tgttatcttc tgaatagcta agcaatgttt acattattta ttcaggcctt

60121
tccatccact ttcacggatt ccactgaagg agaaattggg tttgaaatcc tcttttctca

60181
aaaactaatg agtcatgcat cttctcattg atattatctg gctcccctga aaacctctag

60241
tttggtccat ttttagtgat atctttctac tcaggttcct caaaccaatc tgtacctaag

60301
agacccccag attaaaattc aagttcattc ttttaacaaa ttaggtgcta attgctacaa

60361
atgcaagaaa acttcaggtg ctaatttgtt aaaagaatga acttgaactt tagtctgggg

60421
gtctcttaga tatagattga aaaggattga aaagaattat agtttctttc acttttgcca

60481
tcatacaata tgtattattt atatttcttc ttcgttaata ttcagttcac cttctttgtc

60541
catctttcta ttgaagcacc agtattcatg cagtgtttta agaatattag tccattttta

60601
tccattatgt atattgcaaa taatttcgta ctttattgtc ttttaatttg tttgcagtgt

60661
cctaagagta taaatataat agcttttcta cttttttcat tttttaatat tgcattttct

60781
ctattgtgaa tgttatgctt atgtttttct ccagctgatc tattgaggaa cagtgttttt

60841
ttaataaata taaatattgt tatagttatt tctcatttcg aagttttacg gtactaattt

60901
gtctgtctta aaacttcaaa taatacttaa ttgaaagtct ctgtctacca tcatcccttt

60961
cttaacagtt cggtgaatat cttttattat attgtgtaag gatgttgtat tgcagctcct

61021
cttgctaggc tgaacatgca gacctgttct ggaaatagat gtgatcagtt taggtcacaa

61081
cctgtcttga atcacagctg acttgtagtg gagagttcca ggaaccttcc aatcacacac

61141
aggtccctat tgctcctttt cttctagggc tattcaacaa gcagagacaa acaaaaactg

61201
atctgtcaca ttttactgca ggtaacagtg accacaaata cacctgtaca ctgttttttt

61261
tccaacatta ttgaggtgtg actgacaaat aaaaatggta tatatttaag gtatgtgatg

61321
cgatgttttg ctgtacatgt acattgtgaa atgattatca taatcatgtt aacatatcca

61381
tcacctcaca tattgttatt tttataatca cttttataaa ttttcccttc agtagtaacc

61441
ttttgagatt ctgaaacact tttgagtttt gaatgttgtg tcataagtga gtttttttgg

61501
caaatatttt ataaacatct aattgggaaa ctgtgagagg atgttttgta actttcattt

61561
aaactaagat ctcctctcca cctccaccct tcccatattc agtagatttt ctatggctgt

61621
atggtgtatc aggaatcatc ccatatactt cagaaagtaa tggaataata taaatatttt

61681
tctaacatag acctacagag attaagtgat atactcaaat cataccataa atggtagtga

61741
aagggtaaac tcaacattca cagccaactt cattatctaa tagggaacaa cacatttcat

61801
attaataatt gacttttatt tttaggaggc tctgttataa tgaaattaaa aaatgagatt

61861
agattatgtt tctcaatata tggtacaaaa atcacttaca tagaataact tcgattatta

61921
aaaatagaag tgaaaaatac ttttcagatt aaataagatt tcaattttaa ggcaaatatg

61981
ttcattttgt gctcaaaaat tagacaggaa aactataatc tgttaaaatg taggttcttg

62041
atccacccaa gaaaccatgg agaggtgggg gacagttacc tgcatttctg acagttagtt

62101
cattgactct tattcgacta aactttgaga accagtgtcc aaagtattta cttacatatt

62161
tatatttaaa agctgggata atcatgacaa tataaaataa acaattgatg ttgtatttta

62221
cttggcagat agataaagct atacaagttt cctttttcct aattctaaag cataattaga

62281
aaaaaattgt atttatttct tagatatggt aactactaaa atataatttg gaatgttcta

62341
cttaaatgag tatacttatg tatgcagtta gccgtcaata agatttagtg ttctctgaac

62401
tatttcattt ctatgaaggt ggtattaatc ttgatgataa aattttcttt taaatattga

62461
gagattctgc caaaatataa atcttactgt gacaatgttg ttgaaattcc tttcttcata

62521
tgattatttg ttctaaaata gctcccatga aagtaaaatt cctactctca agcatcctgc

62581
ttaagcatat tgtattgttg ctggtaacta aaaataaagc aaagcattag ggtggatttc

62641
agtgtaattt tatctgttta gtagagtgat acaaatgaat aaattttcaa acatacaaat

62701
tgaccaatta tttgaaagag ctatgaataa aataaataag ctaccttaaa attattttaa

62761
aattatatca caaaattttt ttcctaacaa caaaatatgt atttttaatt gttttggttc

62821
atacaaatta aaatacaaat ataattttac caaggaaagt gaagtaattt aggagtaatt

62881
aataatattt gtgttaggga acggagcata gatactatta aacctaaccg ttttatagtg

62941
catttgtttc taaatccctt aagctggtaa gtcattgatc ttgcattttt ctttgacagg

63001
cttatgcaag caaagatctg gaggagcagt tacggtctgt gtccagtgta gatgaactca

63061
tgactgtact ctacccagaa tattggaaaa tgtacaagtg tcagctaagg aaaggaggct

63121
ggcaacataa cagagaacag gccaacctca actcaaggac agaagagact ataaaatttg

63181
ctgcagcaca ttataataca gagatcttga aaagtaagta tgggaaataa aatgtatagt

63241
aagccttata tatcaaacca gtagaagttg ccagcctggt tctttaattt cagtgtttgt

63301
atcaccgaat acacctttag ggcggaaagc aaatagaaaa taaagaatta cttcaaaata

63361
caacatttta tgatttcact ttgagtatta agatgacttc ataaaataca ggatagatag

63421
gtccatgcat aaacaacaca catttatttt ttcaggtgat agccattgga aaatttttaa

63481
aacagatggc tatattttac atactatatc tgtttaataa cttaaacatt ctttatctta

63541
tcaaataatt ataccttaat ttcctatctg atttggattg agaaatgctt catttgaaat

63601
caccttttca gatgtcactt gttgctttgc tgcttcacag ataactggct cagagcggga

63661
cttaagctga tgaggtatct agcataaagc ttcacaaaaa atgatcatgt tgcataaaat

63721
gtcatagcat caattggtgg ggtatgactg ggcacagagg ttcatgtctg taatccgaga

63781
ccattgggag gccaaagtgg gaggattgct tgaagccaga gtcagagacc agcctgaaca

63841
acacagcaag acctcatctc tattaaaaaa aattaaaaag tggtggagta atttaaaaac

63901
atatttgcct tcagttggta gctcttaatc gctataaaag tttgatattg gaaagtattt

63961
tgagaacaga ggcaaacaaa atggcttcat ggttgtataa ccaatagttt atgtcctttt

64021
ccaaaaattc tattttaggg gaaatatggg ataagtaaac tagtatactt aggaagtaca

64081
ttatttgtaa tgcagaattt aaaaagtcaa cagtattata ggtaagctac taactcatca

64141
gaaacaaaat tccagaggag agttaaaagg gataggaaat attgactttg ctgaagaaag

64201
ttcagaatga gtcccagttg gtgaaaaata gccttgtatt ttatgtagct gcagccacga

64261
cattactcaa ggttgccaaa tagtccgcct gaaaaggacg tttgacttga atctaaaacc

64321
atagcbgtct tctcatatgc aactcagttt taaagaaaaa taaaattata tttatatttg

64381
cattgagagc acaaaaatgg cccatactat agagaatgaa catgactctc tctgcacatc

64441
ttataaacat tcatatatta aattaccatt ttcctaagaa agaaaaacca aacattagtg

64501
ttgtgggata ttggtgtact tttaataaag cataatgcta atttttctta ttgcctagct

64561
atagaaatga gtttaagaaa tatccttagc ttgtcttttc aatgttatat cattctcatt

64621
cacaagtcaa tttaggatcc catcagctgt ctctttagtt atatattgaa cttaaatgtt

64681
aaaatctgaa atgaatgtga gtgatttgca gctgcbgtgg gcttttttta tcttggtggt

64741
ttccgtaaaa cttactgatt tccctatgac ttgacaggta ttgataatga gtggagaaag

64801
actcaatgca tgccacggga ggtgtgtata gatgtgggga aggagtttgg agtcgcgaca

64861
aacaccttct ttaaacctcc atgtgtgtcc gtctacagat gtgggggttg ctgcaatagt

64921
gaggggctgc agtgcatgaa caccagcacg agctacctca gcaagacggt gggtattgcc

64981
cattcctgct acctgcgaga gcccccttaa tcagaagctt taactttggg gatgatgtgt

65041
ttaaacttct ggttgcttta aactaacttg gttcaactca gggtctcata ttttctttag

65101
gggaatgaag tcagtttttc agtgttttgt gtgtttgaca acacagtgtc acaaagaaag

65161
taattgatgc tttattactt tgcaaactct tcatatagtg gagtcaaagc ctcatgcaga

65221
aaacaataaa tatacgtatg tatgtgtgta catgtacgtg tgtatgtgtg tgtgttgatc

65281
ttcaagaata aacatgttca tttggcaata aaatactttt aaatgggtga gttttcagat

65341
ggtggagata acagtgcaaa cagtattcaa agtgtaaaat taaatgcgtg tgttctgtga

65401
aacagtggta tagtattgaa ataagccatc tcactgaaga aatttattgt cttcctgtcg

65461
aaagcaaagg aaataactct gacactaaat ctcagatgtt ttgaataaac tgggaagttt

65521
atctcattaa atggtaagct tctgataacc aggaaatgtc tcttaaggtt ggctttggat

65581
cagggatttt cagaccagac acataaaccc gotttgtggg cottacgtgg tagaggaggc

65641
tggcbgtgga acacgcgtat gtgctggcga taaccatgaa agtgttgttt gaaattgtgt

65701
gcacctctgg cctctgaaca gaaatgtttg gagaaatcca gtcccgtggg ctggactgaa

65761
gcaaacttct cccgaaagac aaaactgtgg ttgtcctaat gacctttcta agctattttt

65821
ggagttagac tcacacacgt aaatctggct aaattcagaa ctgttctttg acctggagaa

65881
tgaaaaatga aattgaaaga tgtggtgtta gatttgattt gtatgatgtg gtatgacaga

65941
aaattcacat tttaatttta tgcaaacttt agctgatcta catggttttc agtaataaaa

66001
cctactctta tttcaatata gtattaatag aaatcagagt taagattact atctcaattc

66061
catgaactac attttttcag ctagctgaat atttccaaaa tttttactgt tacgatcatt

66121
tggcctctga gtttggagac attgtcttat tatacaaccc aaattaattg ctttcttttc

66181
aaaaattgag tttctttata ttgctcaccc acttgataaa gaaacaagcc attttagatt

66241
aagacttgca agaagaaaca aaaaataaat tataaagcta aattttctat tcagcttgcc

66301
tctgcctcaa ctctaaaggt taaaaaaaat taaaaggtga tgctttgggg cctgctatca

66361
tttcttttag tatcatagtt agttaagctt agccagatgc aattcattct gattatttcc

66421
taaaagcaca gcaaaataat gtaggggtcg ttccaacatg tgttctcaag gaatacaatg

66481
tgactctaaa catagtcctg catttagaaa ctttaccaga aaaatgtaca gttgtaggaa

66541
catgacaata tttcagtggt tgccaaaatt ataatatttt tgatagacta acatataatt

66601
atactattgg acatagcaaa agttatcctt agttcattta tcctccctga gtctttatca

66661
aacaacaata aacaataaga cgttatagtt ttgtacttac tattctaaat aaattaatac

66721
tactttaaca ggttttattg gtattatgta ttttatcata accctgaaat caaacaggat

66781
tctttaagat cctctaaatt ttagaactgc atactttaaa ataaattaaa tagaaatact

66841
taggccaagc agatattctt tgaaaggtaa tattcatttt taaaacatat taataattaa

66901
aabittgttt ttatcttcaa gccaaacctc ttaatgggaa ttttggtata ctgagtctct

66961
tgagaaatat gtcatttcct tttaaagtta gagaaaataa atatggatga tttaggaatt

67021
gaaatataca atttttggaa tgccgttaat gatttatatt ttaaaataat tcagttaagc

67081
aatatgatgt attctagatt atattcctaa tatggtattt gatttaaatc aaatagtaaa

67141
ccaaggtact ttggatactg tttccaacta ataagataac cttctctctg ctcttcctcc

67201
ttccatttcc tttcttcata atcttttcta taaattactt tcaagcatat tttttaaaaa

67261
catagatcca aatctatggc taggcatggt ggctcacgcc tgtggtctca gctgctgagg

67321
aggcagaggc aggaggatcg ctggagccca ggagttcagg gctgcagtgt gctaggattg

67381
caccactgca ctcccagcct aggtgacaga gcatgaccct gtttcaaaaa caaaaaaacc

67441
ccacagagct gatgtcagtc tccagcataa aggcctttca gtgatttccc attgcttgta

67501
aaataagaca aaaatctttt ttgaaggtta tatttattga catatcatag ctgtacatat

67561
tttggggtca tgtgttatat gttgatacct gtacaaaatg tgtaatgatc aaatcagggt

67621
aattgggata tccatcatct caaacattta tcttttcttt ctattgggaa caatacagta

67681
cttctcttgc agctttttaa aaaatataca atatatcgtt attcactcca atttccctga

67741
tgtactattg aacactaaaa cttactcctt ctatttaact gtgcttttgt acccctcaac

67801
catcctctct ccatcctccc tacccttgcc cctcccagcc tctgataatc agtattcttc

67861
totctacttc catgagatcc actcgtttag ctcccacata aatgagaaca tgcaggattt

67921
tcaagaccac atctttatca caacctgcaa tctctgcccc atagcccctg ttcagcatca

67981
tctaatgtaa tgattcttga tcttgtgctt ccagtgctct agactttctc caattcctgg

68041
gcatcatcgt gtttcctctg ctcctgggcc cttgcacaca cacctttagg ttaacctggc

68101
cttcctgtct cctctttcct gaggtgctag ctcttcagat cttaatttgg gtgtcaagtg

68161
gctttggcaa ggcctcaggc aagactttct gacctatttg gattagaccc aatatttgta

68221
gtaaatgctt tatagtttcc catattttta aaatagtatt tattacagcc tataatcaca

68281
tagtttatag ttatgtagtc attgttactt gattaatgtc tccctcctcc acaaaggcaa

68341
aaacagatcc gttcactact tatcccagtg cctaccacag aatcagtgca caaatctctt

68401
ttagtatcac ataaaaactg tggacccttt catgagaaca aatgaaaata tagacacatc

68461
cacagcattt ccccccacag ttttagggag tttgttccct gacccctagc cttttccctt

68521
taaaccaggc tttaaaactg ctgccttgaa gattattaat aataaaatag ctgattaaca

68581
cacttgtgga attttcaaat aattggtctt tttgctaaac aaacgtttat gctatcaatt

68641
tagcttgatc ttttaaaaaa tatctgtttc tggagaggaa cagaaaaggt aactattggg

68701
tactgggctt aattcctggg tgatgaaata atctgtgcaa caacccccat gacatgagtt

68761
tacctatgtc acaaacctgc acatgcaccc ccaaacctaa aataaaagtt tacctattta

68821
acaaacctgc acatggaccc ccaaacctaa aataaaagtt tacctatgta acaaacctgc

68881
acatggaccc ccaaacctaa aataaaaccc caaacctaaa ataaaagttt atgtcacaaa

68941
cctgcacatg cacccccaaa cctaaaataa aaccccaaac ctaaaataaa agtttaccta

69001
tgtcacaaac ctgcacatgc acccccaaac ctaaaataaa agtttacctg tgtcgcaaat

69061
ctgcatatgc accgcgaaac ctaaaataaa agtttaccta tgtcacaaat ctgcacatgg

69121
acccccaaac ctaaaataaa agtttaccta tgtcacaaac ctgcacatgg acccccaaac

69181
ctaaaataaa accccaaact taaaataaaa gtttacctat gtcacaaacc tgcacatgga

69241
cccacaaacc tgcacatgga cccccaaacc taaaataaaa ccccaaacct aaaataaaag

69301
tttacctatg tcacaaacct gcacatgcac ccccaaacct aaaataaaag tttacgtatg

69361
taacaaacct gcacatggac ccccaaacct aaatataaac tttatatatg tatgtatata

69421
tatacatatg tatatacaga tatacatata tgtatctgta aaagaaacat atctatctat

69481
atctatatct agatatccag atgactagat gagatataga tatctgtttc tcttacagat

69541
aaggaagaaa attcttcttt attctctcat tcattagtta atatgagcaa aagccaacat

69601
tatatctttc ttactattgg tcaaccaaat aaatgcatac tttacatatg ggccaaatag

69661
atacctaagc ataccttagg taaaatctaa acttggaaaa cagaaaatca gtacattgtt

69721
agtaagcaaa gtaaataaat ttagtcttct attaaccatt tgagtttttt ctgtgaccat

69781
tgcatattca ttttctgcat tggtctaatt aggtgtcaca ttcacccagt gggtattgga

69841
gtgaaagtat ttattcaagg gtaggtgtgt atgctcagta gcataaaaat tgctctatca

69901
agagggaggt gttggagagg tttaggcttt agaaattgca aggcttcgct gggcactgtg

69961
gcttacacct gtaatcccag cactttggga tgccaagaca ggcagatctc ttgagcttag

70021
gaattggaga ccagcctggg caacatagtg aaaccctgtc tccccaaaaa agtataaaaa

70081
ttagccaggc atggtgttgt gcacctgtgg tcccagctac gcgggaggta gctgaggtgg

70141
gaggattgct ggatcctgga aggcagaggc tgcagtgagt aaagatcgca gcactgcact

70201
ccagcctggg tgacagagcc agaccctgcc tcaaaaaaaa aaaaaacaaa aaaaaaacaa

70261
aagaaaaaaa ttacaagggg ccaggggtaa gatgagcatt tagtgctaag tgtaagctgc

70321
atataggtga aataattttg cccagtctac ttagtactta aacatcagat atttgctata

70381
agaaaattgt ctactttaga tcacatggaa tcttttcttg ctgtatttca tctctttcac

70441
ctcccagctt tgcagaattt aggcttactt ttataataga tttacaatgt tgatatgagt

70501
tttgtcaact tcttcccaat catttgcttg tgtgaaaaat caggacttgc ccatgaaatt

70561
tctgaagttt gtctgctttt ttgttattgg ttgatttttt tttcagtttt ttttctatcc

70621
tattggtggg ctatatattt acaataatca caatatttat acattctgat ctgtaatgca

70681
gtcatatttt aaaatttata tagcattagt ttttattttg tcattttaat tttttaaaga

70741
tttgaagatt ttgagaatta aaaatttgta gttcatcaaa aatatggtat ttctcctgag

70801
aattctgacc taagacacct tctctgcaga ctgtaactct ccttgtattt tctcatctac

70861
ttttttttac ttttcccaaa cctttccctc caattcaggc ttctttcctg atttctatac

70921
tgtccactca accttgtgac ttggctgtcc ctcagacagg tcagtctgtc tcacttaaca

70981
gttagaacct attccctacc accttgccca aataagcaag taagtgaatc ctattctttt

71041
tccagtgttc bitgtcttag taaatgacat catcattcag ccagtoggtc aagccaagtt

71101
attcttcctt tcaccaaaac taattgctat tcaatctacc ttgcaaacat ctctaggacc

71161
tatccagtgt ctccacgctg ctaatcccgc tctgatctag gtcacattta ccccttacct

71221
agaccattcc tcttggacaa gcctaataac tggtctccta cctccattct tcctttcctc

71281
caatctattt gccacttttt agcagtgatt tttttttctt ttcttaatgc taagtcagat

71341
actgctaaaa actccttgat aacattgcct tattgggatg gagccagcat tcaactagtg

71401
tggtgataag cttatctttt ctaattgggt tgcttaggcc agcatctggt cagattgatt

71461
ggtacaaatg ttctaagttg ttagtgtttt gaatggaact cttctttcag acaaaatccc

71521
ttaaacataa tttcctgggc cctcaatgat ctggatgcta cctaagtgtc cagcctcaaa

71581
tgtcaatgct tttccccaca aacactactt accactaaga cccaaattct tttcacttct

71641
tgggttatgt caatatctgt cacctccagt attgcaatgc tgtactctgt gtttgaaaca

71701
tctccctaca catgatcccg tatctcgatg tatctagtta atgtctactc atccttaggc

71761
ctaaacataa atgtgacttc caggacattc bittatgtgc ttccacagca tccattgttg

71821
ctgtatctta gcatcattac cttatctgtc agattgtttt atctttgttt aattccctag

71881
gttttttttt tttttttttt tttagatgga gtctcactct tgttgcccag gtgggggagt

71941
gcagtggcag gaactcagct cactgtgacc tctgcctcct gggttcaagt gattatcttg

72001
cctcagcctc ccaagtagct gggattgcag gtgtgcacca ccacacctgg ctaatttttt

72061
gtatttgtag tagagatggg gtttcaccat gttagccagg ctggtctaga aactcctgac

72121
ctcaggtgat cctcccacct ctgcctccca aagtgctggg attacaggtg tgagccactg

72181
cacccagtct tattccatag gttctagact ccatgaaaac aaagattgcg tctgcttgtt

72241
acactgaaca atagcacagt agttggcaca tagcaaacac ttagaagtga ataaaatgaa

72301
tatttgaata aaaagaaaca aatttggggt caaaggtcaa attttgaata tgctgatttg

72361
aaagagtctg aatggtgttt aggtggagat accagaaggt ttgatgtaca attctaaaat

72421
tttagaacaa taactgggtc tttaaatata gatttgggag gaagcatcat tctgataaat

72481
gtcatttgaa gcctggtgtg cttattaatt cttagggtat tgatgtatca caagagaaga

72541
gcaaacatca gtaccaaggg aaagccaaca ttcatcatta gcbgtgccct gcatttccct

72601
ctttgatttt gtattatcat gcccttttcc tatccaaagg attcgcttat atttttgttt

72661
atagtataag gaattttttt ttttttgaaa cggagtctca ctcttgtcac ccaggctgga

72721
gtgcaatggt gtgatcttgg ctcactgcaa cctccacctc ctgggttcaa gcgattctcc

72781
tgcctcagcc tcccgagtag ctgggattac aggtgtccac caccacgccc agctgatttt

72841
gtattttaat agagataggt tttcaccacg ttggccaggc tggtctcgaa ctcctgactt

72901
caagtgatcc actcgcctcg gccacccaat gtgctgggat tacaggcatg agccaccgca

72961
ccojgcagat agttttaatt taaattcagt tagacaagtg catgtggtac acccattatg

73021
tgacgcttca tattatgtac taaaagcatg ctatgcacaa agtgtaggtg tacagtgatg

73081
gatagatcct gccctatgga actaacaaat tagcaagcga aatcaacatt tatcaagtaa

73141
ttaaaagtag tttaagtgtt gtgaaggaaa agtacaaagg cttatggaag tgcatatcca

73201
ggatgtttat aaaccaaggg aggtcgaggc ataaaatttc tgaaagcaag aatgcagtgt

73261
tcctacattt ttactaatat tccaagttct gaaaacgtgt acttaagtag cagcttttcc

73321
tgagtttatt caatttattg cattatcagt gtagtatgaa tgggagtgtg tgatgatttc

73381
cttcaaatat aaaaggaaat ttcttaatgc gttgttttct taaggtaaaa aaaaacaaaa

73441
aaaagacttt toittttgtt aaaagagttc caggcacatt ttgtagcaaa gccaccaatt

73501
ggcatgatgt aaattgtaag gacaatgtac cttaggtaat gttaaactca agttttttat

73561
agatacttca tagaaatgct tttttaaaat gggactcaat gaaggggagg ttatcagggc

73621
gtgtgaggaa gccagcbgtt cattgaaaag taaaagcata tgcactgtgc attccaaagt

73681
atactaatgg ataaaaactg cttcaaagtt ctccacacaa gtatctaagt ggctttgaaa

73741
agttaagtag attggatgtc ttttcaacct ctttcataaa catacacttt gagtatattt

73801
tcttatgaga agttgtatgt ttaagagata taaccaaaaa gtagaaaatg aattttgcag

73861
ggggtaaatt atttggtgat gaaagcagaa gcagaagaaa gtcatctgct tttgaggcac

73921
acatttggat taaaagttac ttgaatgtta gtatttacct tatatatttt actaaatcta

73981
ggaaagaata aagaaaaaca gctcaatctc tagagtcttc ctgaaaatgg tggggttaaa

74041
tcaagctcaa ggaactagaa gttctttgct gtgttcatta gtgccagact aaagaagcca

74101
gtttagttaa gaagctagct tgctatgagc taattctgat acatagaagc agcattattt

74161
taaattctac attgccatct taaaaacaag cagctacttc tttttcatta ttttataaag

74221
caataatatg agcaatcaat aatatgagca tgtatattaa caaagacatg ctcgattata

74281
tttaagttgg atgtttcata aaattttaca acaaaaaata tttaaaccta agtaaaatat

74341
gcaactatat aatgaaatta gaggtattat tttgcactgc agtcagagat atttcttcca

74401
ttaattaaac agaatactgc agcagtctgg aagattaatt tattacattc ctttgtattc

74461
agcaagtgga acgtgatttg tattgtatct ttagcaagtt aatatttggc aagcacagtt

74521
tttggaaatc aggttttatc ctgatgtgga aaaagaactc tatgccagta ccagttatca

74581
gaactttctt taagaataac atttgcctta agaacataat taatgcatct gtgaaaaata

74641
ccactttttt ccaacccaag gtacaatgag attcacgtat tttattcagt atttctaaaa

74701
ctcttcaatt gaggttttta ttttaattgt ggtactgtgt atacttttta tgcataacaa

74761
tatgttaaaa ttaattcagt accagattta aatctgttag gctatctgtt attccatttt

74821
ctttcccaaa cccaatttaa gttccacagg ccttttatag ctggccatgt ggttgcaatg

74881
ctaagtcaaa atgctaagac cttttcccat tttggggcat tatttcttta aattcgttgt

74941
agttttaaaa tctgatttta tagttattaa tcatattctt ctgggggtac atatatctgt

75001
acttaatgga ctaaagtttg gaatatttaa atttaaatta aatatggtag tgagatttgt

75061
tctgaagaga aactggttat atttaggata taatggtgtt ttaaaggaag gcattttttg

75121
tgtcatattt gtatccacac aaacattact tataatttag tactaaatta taactcaaga

75181
tcctctcagt aaggaagttc tacacctttt tcttgaatag ccagcaagat aagtacgatt

75241
aggaattgtt gctttatagc cgttgctatg ctgctgtaaa caacctattg tttcaaaatg

75301
tggctttatt tgaagtccat tctbittggt gagaattgac tattaaatat tcctattaaa

75361
gaatgccagt agattacaac tgggaacctc tcagttggaa acacttgcca tttcctcttg

75421
tttattatag ttttacagaa tatacagtca gatttttttt tcagtttcca accttgctta

75481
aatgcctttt tttatatgtc cttttgatct tctccaaaac caacaactgg tattatatgc

75541
ctaaagtata tgtcaggctt cataatgaat tgtattatta caactttttt tgtgtcctac

75601
attggacaca agttaatatt acttattggt tcagaacaat tcactttatt gtataaaact

75661
gttttagaaa aatcataatt ttcaaaatat caaattataa tagatacatt atcagttaaa

75721
tacatcatca atcagtattt actaaataaa catacttgga gctattagct agtgctgaat

75781
aatacataaa ttttatgtgc tatgaactta aatgtagaac agaaaatact attatataca

75841
caataaagca caaaatagtc tgacaatagt atcatgattc atattttctt aaaataatct

75901
acttactgtt tcaaacattg atatgtttgg atagatctaa actcttttga gaggaaattc

75961
tagttactat gttagttcag atcattatta atggcaagaa caaattgcat aagggaatta

76021
aactccagtg tttacggtaa gctatttggt atttcagaaa ttctaccata gtatctctct

76081
ctgtgtatat gtatgttctc attcaccctc accgtgaggt ctcttttttt ttctttttct

76141
tttttttttt tttttttttt tcggagaggg agtccacctc tgttggccag gctggagtgc

76201
aggtgcagtg gtgcaatctg ggctcactgc aacctctgcc tccojggttc aagaaactct

76261
cctgcctcag cctcccaagt agcbjggatt acaggcatcc gccacgccac ccagctaatt

76321
ttagtatttt tagtagaaac gggatttcac cabittgggc cggcbggtct tgaactcctg

76381
acctcaagtg atcctcccac ctcagcctcc caaagtgctg gggttacagg cgtgagtcac

76441
catgccccgc cctcattgtt aggtttctga tcagcataga ggcaaggtca ttactgatga

76501
ctgttatcct gagattctag caaggtgctt ggtatcatgt aggtactgaa taaatagtta

76561
ctgaaaacta aacaaggaaa gattttaaat aaaaatttta aaatttagaa tttctttaac

76621
aaaaatttaa ctaaatcttg gctgatgtga atgatgataa agaacaagag aaagaagagg

76681
aggaagagaa atccaaacat tacactgaaa tcaccattat tattatccct attttatagg

76741
taatgaaatg gaggcttggg gaagttaggt aatttttcca agtctcagaa gtagtaaatt

76801
gaagatccag gactctaatt actgtctgtt tctcaagact aagtaaactc ttgtttattc

76861
ttacatactt cgtggagtag ggaagttgcc agtgatttga aaatgttatg tatttatttt

76921
gggagggcgc catgcaagtt tataatgcac ttctaattat tattttttca gttcaaaaaa

76981
tgtatatttt ctaagcacat actatctagg aaaaaaagct tacggaaatt cttagtaacg

77041
tagggattaa atatagctat gtaaaaattc acaaagtggt ctgtaaacaa gaaaatagaa

77101
tttactatat ttattgaaaa ggcagtagaa actgtaatca tgtctaactg ataagagtaa

77161
gtcagtcaat atacacacat gagaccagca cagaaagaat tagaaaaatt aaagaggcct

77221
ctttagtatg tgacaagagc tggtataggt acaattatat cttaatacat acccagatgg

77281
catattccca gtagatatta ctaattttcc tgaagttgat agataaataa aactcaatta

77341
tcaagactct ttctactttt aatattatca aaggtatctt tctctggact cttaaaattt

77401
tttcacactg gtatcatcaa gtagcaggtc aaaatttagg gatagaggat gtgtttcaag

77461
agaagaacaa aattttttaa ctttaatttt tcaatctctg ttccttttga caaaattaac

77521
tgaattcagc ctgccaattg ctacttagac acaaaaaaga gaaatgagac attagttatt

77581
aagattttga ttttgattcc tttatgttgt gatttccttt atttccttta agtagttaaa

77641
ctgcaacaaa gatttttttc tctccaactg taaaaaagtc ttccatttta ccacttataa

77701
aagtcttcaa cttagaggaa aagacagttc tctaaacagt gatttggttt tagtgctgtt

77761
ttacctgtct ccttattctt ttagtcagtg tattcaaaaa cacatttctt gcagcctttg

77821
aaagcataga gccacactta gttttccagg aagatgcttt cttaatgtga attagctatt

77881
cttcatctca ccagaacatt cttcaaagct gctgttcctg aattcatgct tgatacccat

77941
gggtggatcc tgatttgtga acattatcta cctaggcatg gatgaggtct ctccatgatc

78001
actgatactg ctcacggcaa tctgtctacc atttggaaaa caggccgggg cagaatctgg

78061
aagggcagcc atcagtggga gcaggaatga tgctgccaag ggttaggggt gggaaaacat

78121
aaactcttct acaatagctg ttagttatct caaatagtgc cttaccttca ctatcaggct

78181
ctgtcctgcc tggtttcact ggagacaatg ccaaatcctg ctgtgcttac ttattacttt

78241
gtttttgcat tgctataaag gaatacctaa gactgggtag tttataaaga aaataggctt

78301
aattggctta tggttctgca ggctgtacag gaagcatgat gctggcattt gctcaccttc

78361
tggtgatgcc tcaggaagct tgcaatcttg gtggaagggg gcgcbggtgt gtcatatggc

78421
cagagtgtga gcaagagagg gaagggagag gtctcagact cctttaaaca accagctcta

78481
gcatgaacta acaggaaaat ctcacttctt accgaaggat ggtgctaagc cattcatgag

78541
ggatctggtc ccatgaccca ttcatctccc gccagctccc acctctaaca ttgggaatca

78601
catttcaaca tgagatttgg aggagacaca gatccaaacc atatcagatt acaaacactg

78661
tgcgtgtaag caaaattgtt tctgcbggtc tgagccactt gagccctttc ccactagtca

78721
catggagcac ctcttcttgt cccccgtctc cactgctgct tccttcctac agcccctgcc

78781
ctgccacagc ccttggaacc acatcgggtg ctggttatct cctgtcaatt cttgttacat

78841
ttgacttccc gaagacatgt ggccctgtga ccacacacac ctgtttgaag ctctcccctc

78901
tttctctggc acccgttggc ttgacagtct cccctcctga tgctccatca ttgttatgct

78961
tcttcccaga catattcact agttcctttg cctcttccca cctcatagat gttcctgtgc

79021
cccaggtttc tattcttaga cattttctct tttcatttag agtgctcatc aagtaatctc

79081
atcaatgtcc aagactccaa ttacagctta aatgttcatg acttttcaat ggctctccta

79141
aactctagac acacatatgt gactgcctac tagacctaaa ttcttaggta caccttccta

79201
ccatctacat tattgcagag cttaaataat caaattataa attatacaaa tataaaaaat

79261
aagtaatttt ataaatttat taaaaattgc tttttaaaac cactttgtat gtcttctgta

79321
gtgctagttc ttaatataga ttccatagat gtcttaaaag atagaaaaat tgtagcttat

79381
gaagacactg cagaattctc tcttaaaata ggtatatata gtgcaaagga ttactgccat

79441
tgcaatattt cacctaatca aagattttat ccaacgtgta taaacgggta tctttttaga

79501
taagaaactg gtcaaaatca taatagtggc atatgttgag gtcacatagt gaagttatct

79561
atgcagatca gacagtattg tggagaatac ctagaatctt gagaatttac acaaatagta

79621
ataacttaga tctgtatagc aaataatata catatcagat tcatttagtt tatgtaatct

79681
ttataatctg agaataatga gtcaagtgtt atccttagtt tactgattat caaagaaaaa

79741
tacagcttgg agaagtcaaa tgaattttcc aaatttatgc tacttataaa tgggagagct

79801
aataaaagcc acctgtctgg gtataaccct gtacctattt cttctaaagc atattgtttt

79861
ctaaagaaag tagttacatt ttaaatgaat atataaggaa tacatcttga atgaagacaa

79921
tatgcatttt ataatttaca tatttctgta tttcattatt cagaattcat ttaaaaagtc

79981
tccttgttgg catggacaaa attggcagct aatcctatcc cataaatatt ttcaatggtc

80041
ttcagctgat ggcgtgaaag ttcagcaaag gccaagtcac aatgctttga agtttgtcat

80101
cttttttatc actgctcaga ttgtcatgaa gacaccaagt aatacatgga tcaattatag

80161
ttaaatgact gcaagttgat cttatcaagc agttagtggg caagatttca cttttaccat

80221
tttttctggt aatgatttag agtgtaagaa cactaggaat ttaaatctac ttagttttac

80281
ttaatcaatg atgtatttgt ttatttaatt taaaacattg tttttggaga aggaagagaa

80341
cacaagaagt tcttgatcca taaataaggc gttcagaagg agaccagtta aactaaattt

80401
tgactgtaat tcagaattgt gtaaaatgcc ctactttatt ttaagctcat tattttcata

80461
attcctttac caagatagca gaaacatggc tttatctatt aaattataaa tgtagttttt

80521
tttgttttaa acataatcaa tttataagag atctaagaca tataaaacta cattgaggta

80581
gaaatttaat aaaaattaac tttacatcta tgtaacttac gtctatgtat tcagtttatt

80641
taaagtaggt cataaccaag tatttctggg ttgtgtggcc aatagctttg ctcctaaatc

80701
acaaagatgt ttctgtgtgt gacacttttt aaatccctgg aatattttaa atgttcattt

80761
caaataatct ataactttga aacagttctt ttttcttgaa cacattgttc tgtcacgtct

80821
aataggataa ccaattagtt ggttatccta attctaatat gcttcataac tagtgacata

80881
agataaacat atggagtatt tattactctg ataaaagata ctggttagga gcaagacagt

80941
ttttactttg taatcataaa aacatagcgt cctgcgtaca ctaggcagct acttatatag

81001
agctaatctc actctttttc ggactccaat atttaccata aaagtgcttt acagcatcta

81061
tataattttt tcttcttttt gtcccttctt tgtagttatt tgaaattaca gtgcctctct

81121
ctcaaggccc caaaccagta acaatcagtt ttgccaatca cacttcctgc cgatgcatgt

81181
ctaaactgga tgtttacaga caagttcatt ccattattag acgttccctg ccagcaacac

81241
taccacagtg agtatgaatt aaatctattt tttctgcatc ctctactaat attaaattat

81301
tttcaagtaa acataagtta aacaaataac ctctgtgaaa tttactgtaa tatactctgc

81361
ttcaaataca aaacaaagac aaaattttgt atagtataca atgaaaataa actgaaaatt

81421
aaaattcagt gggaagcgta ttttagaggc aaagtaattc acaatataaa agaagtatgt

81481
ctgtgaaata aaacacattc caccagtgtt cataaaatat cagtaaggta gcttaattga

81541
tttaacattc ctgaaatcag gtatgctaac tcataaatca tattaaagtt caaaacattt

81601
cagccttgat aagattttag gccaaaacaa aaagtaaata taaataattt tatatctatt

81661
agcattcagt tgctttcttc aatctcaaac ataaaaatat atatgbitgt gtgtgtatat

81721
gtgtatatat gtatctccat gtttcttatt tcagcaatat ttgaatagtg aaatagtgct

81781
taattacttg aaaaaaattt ctgttaatat catttcaaat tgacattcaa accattattt

81841
gttattcagg tttcctttcc atcctatttt tttggagggg caaatggcag catatacctc

81901
atgtgatcat ataggagaac ttatcacgtt ctcctgtatg atcatgttct gaccctgtga

81961
atagctgata atgaattaat atgcattact gcctaagatc tgagagtttt ctgccccaaa

82021
gtagggatgc aaccctttgt tccttaggat atccggtgca tatggatgaa acttacataa

82081
ctctagcatt tgtaacaaat gtataaataa attgatcaaa atacatatat attacaaaaa

82141
agaaaacctt acatttttaa aagactcaac aataaatgta atatgcaaac catggttttc

82201
cccactgaat cacgttgtac tactctgctt agtgtggcag atagggggac cccttgtttg

82261
tccagggaca gtttaggaaa acctggaaga tagcctaatt tgagtgacag agatctgtcc

82321
ccttttatgt gagaaagcaa agatcttaca gacatttgtg aataaatgta tgctaataca

82381
agcaagagac cactaccatc tgaactcaag aggatgccgt atgtgcaatt tcatccccgc

82441
aggctagaga gttctgttca ccttcctcag ccctgagcag aagccctcag tgactcctcc

82501
attctgagag ctttagccat tatctccata ctcatggctt ccaaaatgac atttgaagat

82561
ctaaccatat ttttgactta taatatttta tctaaatcta tcttctattg ctttgcttgt

82621
aattatatta gctgtaagta caaagagaaa gacttgttaa atcctttatt tctacattat

82681
tcatggcagt gttttctcat tttctttgag gccttgaaat cacagagttg tcattacttc

82741
ttcttcttct tctatcccat ctaaacacaa ttgattattt tggaggaggg ggagatatgt

82801
gttccaagct aaacttatat ttcatttcca tcactgccat tatcatccac ttcattatgc

82861
atgtctctga tctaatgcag tgatattaat actagttttc aagcatcaag tctttctcct

82921
gttgtataat gtcactgttt tatgaagtaa gctttaaaag gcatcgtttc attcatctca

82981
ccagaaacag tgactttcag ttgctcaaag aactgagcac aaatttctca ccaccctatt

83041
ctggtgtcag ccttcctttc ttgttttgtc ttccattatt cacccagtct gtgtttcacc

83101
aagtccgatt cccagaacgc caagctcatt tcctgctctg tatcttgttt ctattctggc

83161
cctggcttgt gttctgcctt tccaaagccc tctccatttc tcagagttca ggtaaaggtc

83221
tttctcctgc atttgtcttg tccgaatacc acggccaact ttgcttcttg aatacccata

83281
gcactcactg gattaacttc atcctcacat ggctttatca gggtctgcaa atgttgcatg

83341
tggaactgga ttatgagagt gtttccagta agtttatatt gtctgcaaca ttcagctaac

83401
aacactcaaa aatacttgag ccattcctgt gctctcagcc cctttacctg cattgtctga

83461
tttaaccctt aacaaaatca tctagaaggt cagcagcagc atttgcctta ttttacagat

83521
aaaggtggaa atcacactcc aaagcbgttg gctaaataat gtacataaat gcttgttaaa

83581
taaaatgact catttcctgg atgtatttta tagcatttgc catgttttca tcattactta

83641
ttcatataac tactatccta tacactgttt gaggtcaaga agagacagga agctacagca

83701
aaaagagcct gagtcttaga gtaagccata cctgattctg aattcagatt tgccactaat

83761
tcattctctg tgatcaggta ggtgttttat gtctctgaaa ctcagtttac ttatatataa

83821
actgtaaaga tgtaaagagg attgaatgaa gtactgaatg cttatgcaat gcttagcaga

83881
gtgtctggta tccagaaggt agtcattaaa gggcaaattt attattacca ttaatatcta

83941
agtctgattc atttcctcac ccatgtgttt ttcagtattt ttaaaaccac tatctacagt

84001
aagaaaaaca ttttatattc caaaccagga tgtgtggtat acacacacat agtgtgtctc

84061
tgtgtatata tatatgtcga tattagagaa ttttaaatta gctagataac ttcacatgta

84121
attaattatg tataagcata aaactaaaac aaattaccat ttaaaaatat tgtccttaat

84181
tatggtgctg ctcaagcttt ctcattatca caaccccaag gatcctttta taaacatttt

84241
ttccctaatc actttcccca taaaatttta atgtaacaaa tatactctgt ctttatacta

84301
tatgtatctc tgtgctttat acataaaaag gaagtgtaaa gtttactttt ttgttcaatg

84361
tagtgttaaa taacaaataa aatgtttaag ttaacattta aattaaaaat ttttaatctc

84421
ttaacagcta acataaattt ataattgtat ttgccaggaa acttttaagg taatctgttt

84481
acttatataa attgtaatat atcaaattac atatgcaaag taacaattga tatgaatata

84541
taatacaaat ataataattt ataaaaacat tcaaaatcac tatttttcca gcaaaagtaa

84601
aataattttt aaaataactt ctttaaaaat atttggagag cttaactatt aactttgctc

84661
agtatgagaa aacttttaac ttatatagat gataaatatt aatttagata ttgtcaactt

84721
tttcttttca tcatttgaca tgtaatggta tgactaacat ttgtagaatt aataataaaa

84781
tataaattat tattatttaa ttctcaaagc tcaagtcaca catgaaaaca ccaaggacca

84841
agcataagca atatccacag ggcaaccaat ggcagccaat aggcccacat aggtaccact

84901
cagtatatgt ttgaaatcac tcagtcaatt aagagaaaat cctccagtca tagccatcta

84961
gtcaccataa tttcatagct catatattgc aaacacttgg ggtgtgttcc gttgccaatg

85021
ctgttcatgt aatggccaat aaaaccaaat agaatttaag tattaaggaa tattattttc

85081
ttgggttttg gagagccaaa aatcattgag atattaagat tttagcccca tccaggcctc

85141
atacccaatt tttaccccct tagagatgat tttactccct ttatgaatat ttgccttatt

85201
attacgtgtg atatacccaa ataatttttc tattctgttt ttctttgtga aaatattggt

85261
ctcaaccctt tatgaattat ggcccacaat tcaataaaag ctacactagt gataatatat

85321
atatgatgga catgtgacta tgttataaaa ttctaacatt tgttaagatt taagaggaac

85381
aatcaccacc acggtggcta aaattaaaaa cactgacaaa aacaagtgtt agaatgtggt

85441
gcaaccaaaa ctcctatgtc accaatgggc attaaaattg ttcaatcatt tttcaaaaca

85501
gttgacagtt tcttatgaat ttaacatgta catatttcca cacaataact tgtgtacaaa

85561
tgttctttat tagtcaataa ctggaaacaa ctcaaatgcc catgaaagat gagtggatta

85621
acacatctta gtatatgcat acagtggaac attgctgagc aatgtaaaaa gaatgaacta

85681
ctgatacaca caagaacata aaaggatctc agagacatta agttgagtga aataagcttg

85741
gctaaaaaga gtacattctc tatgatttga tttacatgag gcccttaaaa gacgcaaatg

85801
tactctagag tgagagaacg caattcagtg tttgtttgag gatttggatc aggattgact

85861
gacaatgggc aagagagaca ttgtgaggtg ttagaaacat tctttatttt gattgtgaca

85921
gtagttaatg tggatacata aacttacgaa aagatgataa attcaaaata ggagcatgtt

85981
attgtatgca aattattccc caataaaatt gatttttgaa aagcctagaa aagaattcct

86041
ttattaagta caatttttta agtagcttag gtttcaaata gtagatttct cttttttttt

86101
tttttttttt tttttttttt gagacagatt ctcactctat cacccaggct ggagtacaat

86161
gacgtgatct cagctcactg caacctcctc ctcctgggtt caagcaattc tctgcctcat

86221
cctcccgagt agctgtgatt acagttgccc gccaccatgc ctggttaatt tttgtatttt

86281
tagtagagat ggggtttcac cattctggcc aggctggtct tgaactcctg accttgtgat

86341
ctacccgcct cggcctccca aagtgctggg attgcaggca tgagccacca cgcccagcca

86401
aaatagtaga ttttttaaaa cctttacaat aacattttaa gtcaaatctt tgattaggga

86461
gggagatttc ccacagtcat ccaaaaacta tacgttgagt cactaagata aagaatgctt

86521
ctagatccta ttagagaaaa caaagatgcg cttggctggc tctgaactta gagcacttat

86581
agtcaagtaa gaacaacaca tattatagtt acattattat tgttttattt tactaaatat

86641
tacaaagcac caagcatctg ccacacattg tctcatgttc atacaaatac tgccggtggc

86701
tccattcgta atacacatca catagtacaa ggctgaagag tgtggatgct gtagggagct

86761
tccagttttg agaatttagt ctctgatttc tctttgagtt tgagtaggtt ctgtaaactt

86821
tcttgtgaca catttttttt aatctacaaa agagcacata agtaagaatg ttacatataa

86881
catcatacag aatatttata agctaatctt cactgaaatc aatctgttca atagcattat

86941
accatatttg acataccata gccatgttaa tctgatattg tagaatagca tagtataata

87001
ataataactc ctaactcaag gabittgtga tctttataac cagcaatcca tgttaaatat

87061
tagcacagtg cctaaaacat attaagcatt caataaatga tcgctactat ttttactaac

87121
atcctacaga tttggaaatt gagtcttaga aatgttaatg tgtaaaatgc taaagagcca

87181
aaaaaactgc caggaaaata taaaaattaa aatcatttta tttctgaaac ccatgtgttc

87241
cccccaatat cttctaacat ttctagtatt tacagaaaaa ctttcaagtc tcaatatcag

87301
aaagtttcat aaaagccaga ggaagtagca attctcttta gcagacagag ttagatacca

87361
attttcatat tggtgttctc acagattatt ttttccaatt atttcctctc atattttctt

87421
caaatttaac tccatgtatt tccatgggcc ctttagtaga gactttcttt tcatggaggg

87481
agtcatttgt gattaagtag cgatccccta gattttcctc cttggtagta gtgtttgttt

87541
attcattcat gagacattta tgtcaggtct tctatctcta taatactgta ttaggaaatg

87601
tggggtattt ttaaatgaat aatataattc tttagctaaa ataactcatg tactagagta

87661
caaacaaaca atatttctag tatagtaagt gtctaaaaca ctatgctgta cttcattcac

87721
tcattcaaca aatagcattt gtgtttctgc tagatactaa taaggtggtt agaccacaga

87781
gatagaaaga tacatagaat tgttactcca gaagaaattc cattcttgaa ccagacatgt

87841
aaacatatga ctgaaatcag tgaaatcagt gtggtgagga agcatcttgg agacatggct

87901
acagtagaga ggggatacat gagtctggag aggtcaacag aatcacatat gcccagccaa

87961
ggatgggctg tttcttaaag tctcttgaga actactaaaa gtatatatgc agagatgtgg

88021
tatctgcagt tttgtattat agaaagaaca gcttggtggc aagggagtgt gtggattaga

88081
ggaagcaaaa cgggaggtgg aaaaattcgg gagtaatcat ttgaaataat ctgagtgaaa

88141
aataataaag atggtggcca cagcagtgga tatggggata gaaagaaaag aggtggaaaa

88201
gacgtttgaa atacaagaaa gcatatgact tgggaaccgc atatggggga tggtaaagtg

88261
ggagaagttg aggatgaaac tgtatggatg acattcaaaa gacaaggagc acctgttcat

88321
agtaggaact tacctgaaaa ggagaactga gtttttaaca catgttagct tgagtgcttg

88381
taatatttgt aagacatcag agtggtagag taattggaag agatgacctc aaccaaaaga

88441
aatatagcaa gtaagaagac aagatgagcc acagatgaaa ctgtggggaa atcaatattt

88501
aagaaacagt tatctgtaga gcagacacaa taatctggag aaacagtaat ctgtacggga

88561
gactgagaag aagcaatcag aacaatcgga ataacaacag agagagagac cacaaaagcc

88621
agtggagaca tgagttcaag gaaggaggaa gtggtaagag gtgccaaata ttagaaaggt

88681
tcaagaataa ctgggactta ctctgttagc tgaacagcat gaaatagaga tgtttattta

88741
ctaataactt accatactct gggcacagag agggagaatg tgttttgaga aagggggaga

88801
gaaagcaaga cagtgaaaga aattcacatt tacacatgag aaactgaatc agaaagggta

88861
agtaaatttc cccaatgtca cacaactaga aaagtagcaa agcagagatt caaactaaat

88921
ttgtttggat ataatccatt tcttttgagg tgtggctatg actgcatttt tattgttttt

88981
tagttgatac ataattgtac atatttatgg ggtatatgtg atattttgat acatacatat

89041
aatgcgtaat ggtcagctca ggatattttg gatatccatc acctcaaaca tttatcattt

89101
cttbitgttg taaacatttt aaatcttcta gctattttga aatatataat aaaatattat

89161
taactattgt taccctactg tgcbgtggaa tactagaact tgtttcttct atataactgt

89221
actttggaat gcattaccaa cctctcttca ttccccccac aactgaccca cacttcccag

89281
actctagtaa ccatcattct actctctact tccgtgagat tcactttttg gctctcataa

89341
atgagtgaga acatgagata bitgtctttc tgtgcccagc ttatttcact taacataata

89401
gcctccagtt ccctccatgt tgatgcaaat gacaggattg cattcttttt atggctaaat

89461
agtactccgt tgtgtatata taacagattt tctttatttt taacttctat aaattaaaaa

89521
atatcaaaca tcaaggacaa aacaaaaaca aaacaaaaaa gttcccttct accccaattt

89581
gaaatgtaac aactattttt ttgtatttac taaagataca acccaaatcc ccagtcatca

89641
ttcttcactc ttcattccca gaagtaacca ccactcaaaa attgtattat tctcactctt

89701
ctgtattttt atggcatctg gatttattaa cataccagaa gatattatac agtgcagctt

89761
tgagtgtttt gtattttaag ttaaaatgtt ggcattactt tttttctctt gacattatgt

89821
tttacagata tagtcatatt gctatctgta cacctggtgt attcatttaa taactatata

89881
gcattccatt aaataaacac aagtttttat gtttttttta ttctgtgacg atgtactata

89941
gggaagtcaa tatacactac agattagcaa gagagtacaa tcaaagagga gagagtgatg

90001
tcaaatagac aaggaccttg aagttaatag tgctaaattt attagttatt tggttagcat

90061
ggacaatgtc cctaaagatg taataaaata acacgttctg tgcacagtta ataaaccagg

90121
ttgatttcag tcttaagctg tgaaagcaat tggatattaa atgaaaacac aatactgtga

90181
ttctaaagct ttgagcagca gcctagggaa tttcacctat tctgtagagg tattagggga

90241
gcagaggttg tttctgggta gaggaatgat tgacaagaca abittcagca tagccaagaa

90301
atcttgaatt atttttaatg gataataaat atagaagata ggtattattt caatttggaa

90361
gacagtcgcc tcgtggtgaa aaagagaaaa gggatgaaaa aagatgagga aaaaaaatgg

90421
ataaatctag cctgaaggct aatttgcata tttatttatt tgctgtcttt tatttctttt

90481
attaaaatgt tgacattgtt tactcagtaa aacttatttg cttgcaagaa gttacactta

90541
ctagggttta tttaagaaga ttttattctt atgagaacat gtcttatttc caaggaatag

90601
agtaagtaga tttatagcca aggaaacatt tgatttggaa cttgaggtct ccgtgttttt

90661
ggtotattaa tatttaacag atcctcagtc caaatgccta gatgottaaa tatccataag

90721
ttgtactttt agccataatg cttcactctt tcctttttaa tttgaaggtt atacattatt

90781
gctttaccaa aagacaatga agcaaaatag cctaataaca taaatttaat aaactgtatc

90841
agagcagaaa tggagagata gcttagcttc cagttaattg gaccacagtc tcgtactaga

90901
tcatcagaaa ctactgtttt tcagcatttt aaaacatgca tctttagtct cccctgaaat

90961
tatcctcttt gccagttcaa aatctttatg tccatatacg gttatttttg aaatcgtaag

91021
tcatatgtct gttcatcccc tttcctataa agctcattat ctaaacattg tctcacactt

91081
caaaggatca cctgttgatg tgaatggatt taccagtgga actcaggcaa gagattccag

91141
gctgtgagcg ttactgtttt tgtaaaggga aggtaacttt tatatatagt ttgcctgcct

91201
ttggacagtc ttgtttctac cttctaaaat acgataattg aaagcacagc gttcctatgg

91261
cttgctgata gattgtgaga aataacagca aaatatatac agctgaggag attgcatcaa

91321
tacatctctg caccgaaatt atggcagtga tttgcctaga attgggggct attagatcaa

91381
agattgtcct aaagtttaaa gttacattca accaaacaca tggacaattt ttgttaatat

91441
catattagac cagatttacc agttgttttc taaaatttaa tatacatttt ttaaccattt

91501
taggttacag aaaaagcaga aagtatagag agttttcata taacatcctc tttcacgagt

91561
ttcctctagt tttaacatct tgcattagca tggtacattt gtaacagttg aggagccgat

91621
actgacatgt gatcgttaac taaaatccat agcttacatt agggttccct cttttttggg

91681
tgtaagttct gtggattttg acaaaggtat aaatgatgtg tcaatcatta cagtatcatg

91741
cagaatactt ttactgccct aaaagtctcc gtgttccgcc tgttcatttc tcctcccctg

91801
tattcctggc atcaaccagc cactttgatg tcatatcaac tcttataccc tcataacgtg

91861
ttttttattg tcatcattgt tttgtttttg tttttctgtt aatgacgtat ggctgtgaca

91921
aggtaatgag accagojgct gttgttggag gacctttttt cttaattcct ggttacttat

91981
ccttgaatta tgtgacaagc tgataaatcc aataaccatg gattttccat tgtttcaacc

92041
tgccaatact tctctcaagc ttgtatatcc aagaaaatat aaaaaatagt agagcagaaa

92101
attacaagct tccatactta tcctactctc cctgtgtccc catccccact tctggtggct

92161
ttccaactca gttaagtcct gtacttagcc agttggtgac cacacaatgt gacatgtttt

92221
atatccaagt cagtctcaga ctaggtgagt tttttatgtg gcagattact gcttagttta

92281
tactcagaca aaaaggaaaa aattaaacat ataaacaccc tttttttttt ttcgagagtc

92341
tcatgcbgtt gcccaggcta gagtgcagtg gcgtgatctc agctcactgc atcctctgcc

92401
tccojggttc cagcgattct cctgcctcag cctcctgagt aactgggatt acaagcacgt

92461
gccaccacac ctggctaatt tgtatatttt tagtagagat ggggtttcgc catattggcc

92521
aggcttgtct caaactcctg acctcaggtg atctgcccat ctcgacctcc caaaatgctg

92581
ggattacagg cgtaagccac cgtgcccagc ctaaacccat gttttaaatt aatgcaatga

92641
ttgtattagc ctttcaaaca ttaagactgg caaaattgtt acaactatgg agttttcatt

92701
gattcatcct actcaccatc ttttccttta atatctgaac aaaccccaac tctgttcact

92761
gttctccctg tgagtagact aatggaacaa gagcaaacag taacacaaac agacgctaac

92821
acaagttcat gcagaatcaa taaaaatcag tacaacagaa gataagtcta tgtgtttttg

92881
atacatacga ttaagcatgt gcctttttaa caatttatat aaaacctaaa atatatgtat

92941
ttctgatttt tacctgtagt actgaagaag ttacttaata acgttgaata taaaggccac

93001
ttttacttaa ccaccttcca ttcactatta actgcbgttt ccaaagtgta agcaaatcag

93061
tctctgtgta catagtcaag tgtatacaag cgtcaggcgt aacaaactca agatgaacat

93121
gacagttcaa agatatttgg gacaaaattg ttgaagcatt tttacccagg gctctgtagc

93181
tctgacaatg aaagaatata gttgctcttc cagctgctat tcagacagaa agcttgggca

93241
agaagggtct gtatctatgt tcttcataat acaattacaa gtttgaactt cagataacat

93301
cagcagttgg catgtggaaa accaaaaccc tattttggta tttatcaaga ttgttaatgg

93361
agtcaggttt cccttatttg tttctttaat ggggtacaga acatcctgtt ggataacccg

93421
ctgagtgaca tgacgatgct ctgaaggaat gcatgagagc ttgtggtacc tgccttgaaa

93481
catgggtttc actaatgctg gtggctcaca cttcccattg aacaagacta gagataggaa

93541
ggctatttga gggacacagc tatggaacca taggtgccac atggtaagcc aaatttttat

93601
ttgttgtgtt gttgtgaaaa accttattaa aagagcttcc aatgagagta cttgattaat

93661
aacacagttc gtatctatag aaataatttg cttttcaaga aaatcatcat gtgctacagt

93721
tgaattgaca ttaatgttat cattcatttt gaatgatctg tgaagtattt taagagagat

93781
ctggggaagt aaatcaataa gtagtttaac ataaatcaag gtgcagttaa tttttttcaa

93841
ttagaaatat attacaaaga ttctgtcatt tccaacaacg tgaaataacc tggaggaaat

93901
tgtgctgagt gaaataagcc agacacagaa agatgcatat tactgatctc ccttatatat

93961
ggaatctaga aaagtagaat tcatagatac agaatagaag agtggtcacc acggtcttgg

94021
gggtggggga catggggaaa tgttagagtg tgacaacttg cagttacaag gtgaatatgc

94081
tctggagacc taacgtatag tacagcatag ttactctact caatagtatt ctcactgcac

94141
cccccaactc ccccacacac acagtaactc tttgaggtgt ggatatgtta attagcttga

94201
ttttggtaat catttcacag tgtatacata taccaaaaca tcactttgta taccttatat

94261
atgtacaata tttatcaatc atacttcaat aaagctggaa aaatgcatga atattatata

94321
tatgtatatg tatatacaaa tgtataagag attatagcag attatagctc tttgaaaaag

94381
aataacattt cagcccagtt ctgactaaga ccaaacaaaa ggtgatagca tgttttagtt

94441
ccttaaatgt ggatttgagg agtcaagaaa tctccaagtg taggaaaacc tccgtggcaa

94501
agagtgtaga atatgagaat cacaaaaata gcatgcacaa aatagcctgc tgtgatgttg

94561
aaagtataag agctagtaat tattattatt attattattt ttatttttat tattatactt

94621
taagttttag ggtacatgtg cacattgtgc aggttagtta catatgtata catgtgccat

94681
gcbggtgtgc tgcacccact aacttgtcat ctaccattag gtatatctcc caatgctatc

94741
cctccccctc cctccacccc acaacagtcc ccagagtgtg atgttcccct tcctgtgtcc

94801
atgtgatctc attgttcaat tcccacctat gagtgagaat atgoggtgtt tggttttttg

94861
ttcttgtgat agtttactga gaatgatgac ttccaatttc atccatgtcc ctacaaagga

94921
catgaactca tcatttttta tggctgcata gtattccatg gtgtatatgt gccacatttt

94981
cttaatccag tctatcattg ttggacattt gggttggttc caagtctttg ctatcgtgaa

95041
taatgccgca ataaacatac gtgtgcatgt gtctttatag cagcatgatt tatagttctt

95101
tgggtatata cccagtaatg ggatggctgg gtcaaatggt atttccagtt ctagatccct

95161
gaggaatcgc cacactgact tccacaatgg ttgaactagt ttacagtccc accaacagtg

95221
taaaagtgtt cctatttctc cacatcctct ccagcacctg tbitttcctg acttttgaat

95281
gattgccatt ctacgtggtg tgagatggta tctcattgta gttttgattt gcatttctct

95341
gatgaccagt gatggtgagc attttttcat gtgttttttg gctgcataaa tgtcttcttt

95401
tgagaagtgt ctgttcatgt ccttcgccca ctttttgatg gggttgtttg tttttttctt

95461
gtaaatttgt ttgagttcat tgtagattct ggatattagc cctttgtcag atgagtaggt

95521
tgtgaaaatt ttctcccatt ttgtaggttg cctgttcact ctgatggtag tttcttttgc

95581
tgtgcagaag ctctttagtt taattagatc ccatttatca attttgtctt ttgttgccat

95641
tgcttttggt gttttagacg tgaagtcctt gcccatgcct atgtcctgaa tggtaatgcc

95701
taggttttct tctagggttt ttatggtttt aggtctaacg tttaagtctt taatccatct

95761
tgaactgatt tttgtataag gtgtaaggaa gggatccagt ttcagctttc tacatatggc

95821
tagccagttt tcccagcacc atttattaaa tagggcatcc tttccccatt gcttgttttt

95881
ctcaggtttg tcaaagatca gattgttgta gatatgcggc gttatttctg agggctctgt

95941
tctgttccat tgatctatat ctctgttttg aaccagtacc atgcbgtttt ggttactgta

96001
gccttgtggt atagtttgaa gtcaggtagg gtgatgcctc cagctttgtt cttttggctt

96061
agggttgact tggtgatgca ggctcttttt tggttccata tgaactttaa agtagttttt

96121
tccagttctg tgaagaaagt cattggtagc ttgatgggga tggcattgaa tctgtaaatt

96181
accttgggca gtatggccat tttcacgata ttgattcttc ctacccatga gcatggaatg

96241
ttcttccatt tgtttgtatc ctcttttatt tccttgagca gtggtttgta gttctccttg

96301
aagaggtcct tcacatccct tgtaagttgg attcctaggt attttattct ctttgaagca

96361
attgtgaatg ggagttcact catgatttgg ctctctgttt gtctgttgtt ggtgtataag

96421
agtgcttgtg atttttgtac attgattttg tatctggaga ctttgctgaa gttgcttatc

96481
agcttaagga gatttttggc tgagacaatg gggttttcta gatatacaat catgttgtct

96541
gcaaacaggg acaatttgac ttcctctttt cctaattgaa taccctttat ttccttctcc

96601
tgcctaattg ccctggccag aacttccaac actatgttga atagtagtgg tgagagaggg

96661
catccctgtc ttgtgccagt tttcaaaggg aatgcttcca gtttttgccc attcagtatg

96721
atattggctg tgggtttgtc atagatagct cttattattt tgaaatatgt cccatcaata

96781
cctaatttat tgagagtttt tagcatgaag ggttgttgaa ttttgtcaaa ggctttttct

96841
gcatctattg agataatcat gtggtttttg tctttggctc tgtttatatg ctggattaca

96901
tttatttatt gatttgcata tattgaacca gtcttgcatc ccagggatga agcccgcttg

96961
atcatggtgg ataagctttt tgatgtgctg ctggattcgt tttgccagta ttttattgag

97021
gatttttgca tcaatgttca tcaaggatat tggtctaaaa ttctcttttt ttgttgtgtc

97081
tctgcctggc tttcatatca gaatgatgct ggcctcataa aatgagttag ggaggattcc

97141
ctctttttct attgattgga atagtttcag aaggaatggt accagttcct ccttgtacct

97201
ctggtagaat tgggcbgtga atccgtctgg tcctggactc tttttggttg gtaagctatt

97261
gattattgcc acaatttcag atcctgttat tggtctattc agagattcaa cttcttcctg

97321
gtttagtctt gggagagtgt abitgtcgag gaatttattc atttcttcta gattttctag

97381
tttatttgca tagaggtgtt tgtagtattc tctgatggta gtttgtattt ctgtgggatc

97441
ggtggtgata tcccctttat cattttttat tgcgtctatt tgattcttct ctcttttttt

97501
ctttattagt cttgctagca gtotatcaat tttgttgatc ccttcaaaaa accagctcct

97561
ggattcatta atttttgaag ggttttttgt gtctctattt ccttcagttc tgctctgatt

97621
ttagttattt cttgccttct gctagctttt gaatgtgttt gctcttgctt ttctagttct

97681
tttaattgtg abittagggt gtcaattttg gatctttcct gctttctctt gtgggcattt

97741
agtgctataa atttccctct acacactgct ttgaatgcgt cccagagatt ctggtatgtt

97801
gtgtctttgt tctoittggt ttcaaagaac atctttattt ctgccttcat ttcgttacgt

97861
acccagtagt cattcaggag caggttgttc agtttccatg tagttgagca gttttgagtg

97921
agattcttaa tcctgagttc tagtttgatt gcactgtggt ctgagagata gtttgttata

97981
atttctgttc ttttacattt gctgaggaga gctttacttc caagtatgtg gtcaattttg

98041
gaataggtgt ggtgtggtgc tgaaaaaaat atatattcca ttgatttggg gtggagagtt

98101
ctgtagatgt ctattaggtc cgcttggtgc agaactgagt tcaattcctg cgtatccttg

98161
ttgactttct gtctcgttga tctgtctaat gttgacagtg ggtgttaaag tctcccatta

98221
ttaatgtgtg ggagtctaag tctctttgta ggtcactcag gacttgcttt atgaatcttg

98281
gtgctcctgt attgggtgca tatatattta ggatagttag ctcttcttgt tgaattgatc

98341
cctttacgat tatgtaatgg ccttttttgt ctcttttgat cttbittggt ttaaagtctg

98401
ttttatcaga gactaggatt acaacccctg cctttttttg ttttccattt gcttggtaga

98461
tcttcctcca tccttttatt ttgagcctat gtgtgtctct gcacgtgaga tgggtttcct

98521
gaatacagca cactgatggg tcttgactct ttatccaatt tgccagtctg tgtcttttaa

98581
ttggagcatt tagtccattg acatttaaag ttaatattgt tatgtgtgaa tttgatcctg

98641
tcattatgat gttagctggt tattttgctc attagttgat gcagtttctt cctagtctcg

98701
atggtcttta cattttggca tgattttgca gcggctggta ccagttgttc ctttccatat

98761
ttagcgcttc cttcaggagc tcttttaggg caggcctggt ggtgacaaaa tctctcagca

98821
tttgcttgtc tgtaaagtat tttatttctc cttcacttat atgaagctta ttttggctgg

98881
atatgaaatt ctgggttgaa aattcttttc tttaagaatg ttgaatattg gcccccactc

98941
tcttctggct tgtagggttt ctgccgagag atcctctgtt agtctgatgg gcttcccttt

99001
gagggtaacc agacctttct ctctggctgc ccttaacatt ttttccttca tttcaacttt

99061
ggtgaatctg acagttatgt gtcttggagt tgctcttctc gaggagtatc tttgtggcat

99121
tctctgtatt tcctgaatct gaacgttggc ctgccttgct agattgggga agttctcctg

99181
gataatatcc tgcagagtgt tttccaactt ggttccattc tccccatcac tttcaggtac

99241
accaatcaga catagatttg gtcttttcac atagtcccat atttcttgga ggctttgctc

99301
atttcttttt attctttttt ctctaaactt cccttctcgc ttcatttcat tcatttcatc

99361
ttccattgct gatactcttt cttccagttg attgcatcgg ctcctgaggc ttctgcattc

99421
ttcacgtagt tctcgagcct tggttttcag ctccatcagc tcctttaagc acttctctgt

99481
attggttatt ctagttatac attcttctaa atttttttca aagttttcaa cttctttgcc

99541
tttggtttga atgtcctcct gtagctcaga gtaatttgat cgtctgaagc cttcttctcg

99601
cagctcgtca aagttattct ccatccagct ttgttccatt gctggtaagg aactgtgttt

99661
ctttggagga ggagaggcac tctgcttttt agactttcca gtttttctgt tctgtttttt

99721
ccccatcttt gtggttttat cgacttttgg tctttgatga tggtgatgta cagatgggtt

99781
ttoggtgtgg atgtoctttc bitttgttag ttttccttct aacagacagg accctcagct

99841
gcaggtctgt tggaataccc tgcbgtgtga ggtgtcagtg tgcccctgct ggggggtgcc

99901
tcccagttag gctgctcggg ggtcaggggt cagggaccca cttgaggaag cagtctgccc

99961
gttctcagat ctccagctgc gtgctgggag aaccactgct ctcttcaaag ctgtcagaca

100021
gggacattta agtctgcaga agttacttct gtctttttgt ttgtctgtgc cctgccccca

100081
gaggtggagc ctacagaggc aggcaggcct ccttgagctg tggtgggctc cacccagttc

100141
gagcttcccg gctgctttgt ttacctaatc aagcctgggc aatggcgggc gtccctcccc

100201
cagcctcatt gccgccttgc agtttgatct cagactgctg tgctagcaat cagcgagact

100261
ccgtgggcgt aggaccctcg agccaggtgc gggtataatc tcgtggtgtg ccgttttttg

100321
tttttttttt gtttgtttgt ttgtttgttt ttgagacgga gtctcgctct gtcgcccagg

100381
ctggagtgca gtggcgggat ctojgctcac tgcaagctcc gcctgccggg ttcacgccat

100441
tctcctgcct cagcctccca agtagcbggg actacaggcg cccgccacta cgcccggcta

100501
attttttgta tttttagtag agacggggtt tcaccgtttt agccgggatg gtctcgatct

100561
cctgacctcg tgatccgccc gcctcggcct cccaaagtgc tgggattaca ggcgtgagcc

100621
accgcgccgg gccggtgcgc cgttttttaa gcccttcgga aaagcgcagt attcgggtgg

100681
gagtgacccg attttccagg tgctgcccct cacccctttc tttgactagg aaagggaact

100741
ccctgaccac ttgtgcttcc caagtgaggc aatgcctcgc cctgcttcgg ctcgcgcacg

100801
gtgcgtgcac ccactgacct gcgcccactg tctggcactc cctagtgaga tgaacccggt

100861
acctcagatg gaaatgcaga aatcacccgt cttctgcgtt gctcaggctg ggagctgtag

100921
accggagctg ttcctatttg gccatcttgg ctcctcccca agagctggta attattaccc

100981
aacgtttaga atataatgta acagaacgta tttggaatac atttatcttt taatatttca

101041
aaggagagat aaatgcaaac taagatttta tttatcatta aattcattgt tctttagttt

101101
gaaaaacaca tatactcata tttttgtcac gtgattttaa ccagcataaa gcaatagctg

101161
ccacaccaaa gtcaagtgaa gctgtgaaaa taattaatga aacaattctg ataaaagcat

101221
ctttatcctt catacaggtt ataggcagga ttgtggttgt gcctgtgtgt gtgtgtggtg

101281
gggtoggtgg ggggatagga aagttagttt attcacatga ttctcaacat agacatacct

101341
tgcaaataat tgtgcaattc cctgctttgc tttgcagaca gaatgtcttt gaatcaatgt

101401
cttttataaa tacactatac aaaaaacata attataaacc tttaaagtat ttatgcatac

101461
tttaatattc agaactagaa gagaaatttc tgtaaggaga aatgctttgg agattaaaac

101521
gtaaaggaga taaccaaatt ttactaaacc tctatccatc atgaccacat ttcctttcat

101581
tctaaaataa aaatattttg gaaatgttga ccccctgccc accatttttg cctgagaagt

101641
tttaaatgcg aagaacttgc tcctcacttt tgaagcacgg tgctttcttt aggaaccaat

101701
ctgtatcaca tgcattctat tggtttgtat tttattacat atcattctat tacattttaa

101761
aatgcatttc tgagcccatg tcattgattt catgattcat taatgggttg caagcagcag

101821
ctggaataac actggcttag gtaatggcag tataaatcac abittggtaa aatgaaagat

101881
gcctttctac caacacgtta taatggccac tcgatgccaa catggcagtg tgttacttaa

101941
accatatatc aatcaacaca gaagcgacat aaccaaaatg tttttaccat catttataga

102001
agattatgag tttcatgcag ccaggattaa ttgcattgct attatagaac ttaatataag

102061
ttgtatcata tttgatggaa ggatgctaac tatcaagagg atataaattt taaaaacaat

102121
gatactgttt tggataagtc ctgactgtct gcattttatc tagaacaata tatgttcatg

102181
attaacctag aaaataatga caaaaatgcg caatgagtag agacttgccc ttggaattcc

102241
taaaattatt aggaaggtac aatgttctcc aagaaatatt ggtaagtgaa aaaaacaagg

102301
tttacaataa tgtgtaacgg atgctatctg tgtaacaaaa tgtgaaaaaa catatatgca

102361
attttttggc aagaagatac cctgaaaaca taaaccaaaa agccaaaaaa aaaaaaagaa

102421
acttgctgat gatacagaac ttctctgact gtacattttt ctcatagtct taactctgat

102481
aattacatac atgtttgaca ttctcaaaag taagaacata gaagtacata atatatgcag

102541
gataaagcaa ataacagttt atgtgaagat tgttagaagc caaggttttc atggaagtta

102601
ttagtatgaa gtcaaagtag tacattaaaa tccagtaatg ttaattggat ttggaagtaa

102661
cagtatgaaa ttttttctct aaaaatgtgt gcaggaatct cttgcttaag atcagtaatc

102721
tattcccaaa aatagatttt gagagcacat ttctgttcta aatgggaaca attatagtga

102781
atggaaggta aaccaaaaca tagctatttc ctacaaaata attgatacct aataatgcct

102841
gtagaaaagc atagaaaagt gacaaactct cttgataaaa tctaaaatgt atattgtttc

102901
ctaatcagca attattgatg ttgctaacat acagttgctt tgtatctagt tacatggacc

102961
gtgtatatgc tgtatgagaa attgtcactt tgtggtatag catagcaaat aacacagcaa

103021
tcaaaaagtt aaaagtcaaa attaaaataa ataaaagacc cataatagac tgtttttcac

103081
cttgctaaag gagaaatgac tcttgaagaa actcaagaag ggacaaagaa aggtcaaatc

103141
agtcattgct atttgcagaa ggtgatgggt ggatggagga caagggggca atcttcgaca

103201
aactgtcata tgaagaggaa tgaagagacc ttccccatgt ctgtgtctag tagatgctgt

103261
agagacttgc tggacaggaa agctttggta aatcttcaga aatgatgttc aagctgaagg

103321
aagatgttca agctgcattt tggttgcaaa atgcagattt gcttgttttt ctgttgaaaa

103381
attcctctat gtgatgctgt aagagttacc aggctattat taaaagaaag atgtattgtc

103441
acactgagta tgtctgcaaa actttcttag taactggcct gtttgtttat actcaatgca

103501
catgttaaga tggctacata ggattcttac tatgttctat caatttggaa tgtaactcaa

103561
cattcttcca gcacataaag ttgtttacaa tatataatga gtgtgaaaga tataaataaa

103621
tacttctatt tgatgtctac accaacatta gatgaaaaaa tgaggtagtg agaagttgat

103681
atatatcctg taaattagca tatttaaaac caaaaatcct tctactgggt aaatattaac

103741
taggaaaaca ttctacagga tataatgcat ttttctagct ctgccccctg aaaaggtcta

103801
gtagtaatgt gatctgatgg cactaaacac ttctgatctc aaatgatagc ctctaaaatg

103861
ctgttttcca acaaagagaa ttagggctcc tgaagaaatg gctgatgcca ggtgtggagg

103921
agaaaatgag caagctgagc ttgtgatata tgttcacccc agagagggct catgtcacgt

103981
gggcaccaac agagaggggt ctcaggtagc aacagtgggg ccattggacc atcaaaggag

104041
caattagggt acttgactga agcctgtagg ttcataattt ttactctaaa acaaggaagg

104101
aaggtgggaa gaaaggggaa aggaggggaa gggaaggaag aaaggaggga gggagggaag

104161
gaaggaagta aagagctaga acaacaatga aacaaaatat ctttgataac tttttggggg

104221
agtacagagt ggaaattttg catttctgga ggctttacaa gatggggatc tgtgcttcag

104281
aaataagtca gtaaagatac atttacatag atgtttcctc cagtattgct tggaaaagcc

104341
aaaatcaaag tgatgtagat agttacctaa gagatgaata aaataaataa tggtacatct

104401
tttgtatgga atattacata gccactaaaa ataatggagc agaactctac tcaatgacat

104461
ataaaaatgt ccatgatata ttgtataatg gaaaaaaatt ttaaagcaaa aggttttacc

104521
ttatttattt cacaagctaa aaccctatat gattatacaa accaatgtgt ttgccttaaa

104581
aagataaaag tctggtgtcc tctaagacca taccacaaac agtgatcacc tctgggattg

104641
gaattttata gcagttgtgg gtagagagag tttgggagaa aacattcaca ttttatctca

104701
taattcttat atttttaaag cttttctatg agcattattt tgatacatat gtgagcagag

104761
atggtccctt ctaggtacca gttacaccat tgctaaacct cgtctgtttc ttccaaaggt

104821
gtcaggcagc gaacaagacc tgccccacca attacatgtg gaataatcac atctgcagat

104881
gcctggctca ggaagatttt atgttttcct cggatgctgg agatggtaag cagaatgatg

104941
ctttaaagac taaacgccag gggtctatat tgtgattaac atactctaat attaaaacca

105001
cacatataat attcatcatt cttctaaata agtgactaaa aaatagtaca ttttctactt

105061
cacgttggta ttattttgaa ctcctttata aaggaacata ctcatgtttg tacccaatcc

105121
tttgatggaa aacatacaaa aggaagatgc ttttaaaagc ttttgtttca tgccacaccc

105181
agaaccaagt aaggtatagt aaagattctc tgactatttg tctagactca acagatggat

105241
tccatgacat ctgtggacca aacaaggagc tggatgaaga gacctgtcag tgtgtctgca

105301
gagojgggct tojgcctgcc agctgtggac cccacaaaga actagacaga aactcatgcc

105361
agtgtgtctg taaaaacaaa ctcttcccca gccaatgtgg ggccaaccga gaatttgatg

105421
aaaacacatg ccagtgtgta tgtaaaagaa cctgccccag aaatcaaccc ctaaatcctg

105481
gaaaatgtgc ctgtgaatgt acagaaagtc cacagaaatg cttgttaaaa ggaaagaagt

105541
tccaccacca aacatgcagg taagagatcc tcatgaagaa tattaattta tcttactaga

105601
aatatgctct aaaccaaaag cagttttctt aaccaaagta acaattgctt gttagaatga

105661
ggccaataca ttctgaaaga caaaaatctt atattttttt aaccaatgct aaacttgcat

105721
gagactggat ttgcttccaa aaaagcaaga caggagcctt gaggatcaaa attagatcca

105781
agctcagaat atactctaaa ttagtggttc ctgtgggatg ttttcaaaat acctaaaggc

105841
aatccacttc acccccacca aaaagtagga tgccttcaga cataatttag gacaactgtt

105901
ctaaatgcag acaattttta tgcaaaactt acaaacaaag gacaggagag taccactggt

105961
atagaattat atctggaaat gaaaatacat agctaagtat ttgatagaat tagagaaata

106021
aatgaatatg ttgttaaagg tacccaagac tcatgtctta aacttggttt tgactcttct

106081
gcatcaagaa aaaaaaaatg aagttattcg actcaagcac attcagtgtt aatcccgaaa

106141
cctcttcctc tttaatctca gagaataaat tgatcctact atttaagcca gacctgtccg

106201
tttgacattt tctccacatt ccttcaacat tgcttcatgc cattccttct ttcttctgta

106261
acttgaacat cttcaactct actttttttc cccttagttt ataaaagttc ccaaatttct

106321
tctattttat tagcctctta ctgtgaagtt gagcaaactt tagcaaccca ggtctgttct

106381
cttcaaagct gctcaaaaac gaggcatttg ttttcacctc tttcacctac catgtattca

106441
accaactaaa acctggttta tggcctacag tgctatgtta aacctctgtt taacgtttca

106501
ttggcctcat agttgccaaa tccaacagag aattttgtcc ttaggtaacc tgtcctttcc

106561
atggcctttt tctttaagct cacctcttct atgacatgac attgtacttt cctagttgtc

106621
tacttaattt tcagaccatt tgtttttaat cactttcact ggattctctt tttacatcca

106681
ttctttacat atgggtagat aatgttcttt ttaacagaaa aaagcttgta tttcatttat

106741
ttactatctt cactaatgtt cattattatt tttccacagt atataacgag ttcatctttt

106801
tattctcaag agttttgtgt ccttatttta atgtatattt ttggtggttt tcctaaacta

106861
atattttagc tactggataa aaaggcttta gtggatctgg ctatctcatt gattatattt

106921
ttcttccctt atactgcaaa gtacatcata ggtataattt tattttgaga aagaactata

106981
ttccaatttt acctatatat tcctactgta ataaccaaga ggacatttca aaaatgtata

107041
tgctactatt ttcagaagga tatagatact aaatcttttt aagccttatt aaactatgtt

107101
ttatattgaa ttcttattga gtgaatttag tatacattga aaaatctgaa attcttatgt

107161
ctgcatacct acttttctac agaattatat gaacacagac aatatttcta tcattgcatt

107221
tctcctaata ctatacattc tttcaaaaag actctgttta ctgcaactca tcctagattc

107281
atttttctaa gtgtataatt ccaagctttg tgatataaat tggagcaaaa gagaaaatat

107341
catattttga aaatatatat tctcctcatt ctctcttaat atctattaca aagtgcagta

107401
ggcagagtat atattctttg gttcattgcc ttaattaaca gcttttatgg atcattaagt

107461
atcatatccc tttttagtag aggaatacca gtagtcataa ctatgaattt gcatttgcaa

107521
agtttaagaa aaattaacta gacatgcttt cttttctaga gccaaataaa tgaaatgtca

107581
aaaccaaatt gtgtagggtt ttttatagca cacttttgat ttccacctca ggtcatcttg

107641
cacttttccc tttacaccta ttcccacaca ttaggcatgc tcatactcca aaatgttttt

107701
aaaagatagc tccaattctc accaggcgtg gtggctcaca cctgtaatcc tagcactttg

107761
gaaggccaag gcgggcagat cacttgaggc caggagttca agaccagccc agccaacatg

107821
gcaaaaccct ggctctatga aaaatacaga aacttagcca ggcgtggcca cacatacctg

107881
taatcccagc tactojggag gctgagacac aagaatggct tgagcccagg aggcggaggt

107941
tgcagtaagc tgagattgcc ccactgcgct ccagcctggg cgacagaaca agactctgtc

108001
tcaaaaaatg aagcctcaat tcactggagc aacagggcag gagacacact gaccaattga

108061
taatttgtcc tctcaccgct actggaaact ggaagtctag gatgggagga aggggaccct

108121
cgctgctgag tattgtcctt ctcacctccc tgccccagaa tgcctctgtt tcacctggag

108181
ccaaggtgga aaggaagagt tagtcaccgt catgcagcca gctgccaagt agagacacaa

108241
gagtgagggt ggggctgctc actgaggacc acagttctgc caacatggct gggtttaatt

108301
gcctggaagt ctgggtccca tacaagtccc agactcatgt gaattctgcc atgcttatgt

108361
gatcacagta agtcagcaga ccttcagtgt tcactttcag aatttctgtt ttatgtttct

108421
ttcacccatg aagcaaagag cacttcaaag gaactaatgc ttacaatacc tcatccttcc

108481
atttgttata tcagcaagca agacttttat tttaaggctt ttccattcct cttaaatgtt

108541
gtaattctaa gcagaaacaa acttttttaa acctatgaac aatttcgtca taaaattagt

108601
aattttattc cagtctgaaa tttaaaaaca cagaaatacc ttggtagcat gatgaatcca

108661
ttgccttgat ctttaacgta agtgtgttct tgtttgttct cctagctgtt acagacggcc

108721
atgtacgaac cgccagaagg cttgtgagcc aggattttca tatagtgaag aagtgtgtcg

108781
ttgtgtccct tcatattgga aaagaccaca aatgagctaa gattgtactg ttttccagtt

108841
catcgatttt ctattatgga aaactgtgtt gccacagtag aactgtctgt gaacagagag

108901
acccttgtgg gtccatgcta acaaagacaa aagtotgtot ttcctgaacc atgtggataa

108961
ctttacagaa atggactgga gctcatctgc aaaaggcctc ttgtaaagac tggttttctg

109021
ccaatgacca aacagccaag attttcctct tgtgatttct ttaaaagaat gactatataa

109081
tttatttcca ctaaaaatat tgtttctgca ttcattttta tagcaacaac aattggtaaa

109141
actcactgtg atcaatattt ttatatcatg caaaatatgt ttaaaataaa atgaaaattg

109201
tattataagc tg

Human VEGF-D Gene (NCBI Accession No. NG_012509.1)

(SEQ ID NO: 83)

1
aagacacatg cttctgcaag cttccatgaa ggttgtgcaa aaaagtttca atccagagtt

61
gggttccagc tttctgtagc tgtaagcatt ggtggccaca ccacctcctt acaaagcaac

121
tagaacctgc ggcatacatt ggagagattt ttttaatttt ctggacatga agtaaattta

181
gagtgctttc taatttcagg tagaagacat gtccaccttc tgattatttt tggagaacat

241
tttgattttt ttcatctctc tctccccacc cctaagattg tgcaaaaaaa gcgtaccttg

301
cctaattgaa ataatttcat tggattttga tcagaactga ttatttggtt ttctgtgtga

361
agttttgagg tttcaaactt tccttctgga gaatgccttt tgaaacaatt ttctctagct

421
gcctgatgtc aactgcttag taatcagtgg atattgaaat attcaaaatg tacagagagt

481
gggtagtggt gaatgttttc atgatgttgt acgtccagct ggtgcagggc tccagtaatg

541
aacatggacc agtgaaggta ggtgagctca atttttaatg tgatgaagtt ctttttattg

601
gctcatacag aggactttct ttgccctcac tatttttgaa acaatataaa aatgcagaac

661
catcctagta gtggactgga caggatatat cctgcatttc ttggtgactg ttctgtttct

721
tagtcttatt aaacttctgg ccatgagtat ttgaaaatgc tggggtgggg gttggttgtt

781
ttttgaagtt atggtagaac atgagcagtc tggaatcttt ttggatggag aagtttctcc

841
toggttgcat atgcagatgg cacagtggtt ttttaatgaa acattgattt gtttttatga

901
ctgataactt tgtgggccat ttattttcag gtctttgtga gcagcagagg ttagtttatt

961
cgtttggtaa attgaaaatt gcagtgcttt ctatgaacat tttctatctg cttttgcaaa

1021
ttaccaattg ctgccatcca gaaaaatgtt ttctcagaga gtgtttggtt ttttcgcttc

1081
ttgaaaggtg taaaattcaa cactaatcaa atctttggtt ctgtgagcaa gcatcaaata

1141
gagcttaacg aacagagagt aatgcaaaaa attaaccaga atgttgctga ctgctggaac

1201
aatacttagc ccaattttat gcatttcatg gattatatat attttaagct tctattttga

1261
aaatgattcg gatgtaattg ttttgactga agtggtgcta aatcattatt gatttaggaa

1321
cttctggcct tgaaaagaca attaaatgtg agtttgagtt tttgtagctg ttgtttagga

1381
cgtgcatttt caacaggggt gatatcgccc ccagcagggg aaaattggtt cgtggaggga

1441
tgaaaaagtt ttaccctttt gatacatcac gcacagacgt acatacagta catatggtat

1501
gtagtttaaa atacgttata cattcaaatt gcataggggg aaagtgtctt caaaggctcc

1561
tggcbggtgt tggtggcctg gcgagggtgg gggctgatat ttaaaaatgt tgaacactga

1621
gctggaggtg agtgggaagt caccttgtct ggcagccagc acttttctaa cttctcaaat

1681
tccaaattta catgggagaa atcacagtgt ttggctccat tttactgcca ccagccttga

1741
tattggatct caaggccaga ttgtaggtaa atgggaatct gactgtaagc ataggtaaca

1801
ggagaaaacg gtctgacttg tttgaagcaa gtaagacttt tccgactgtc cagctttttc

1861
gtaagttcat gaaacagaaa tcctttagat gtgctgggct cctcgagttt taaaatattt

1921
ccattttcct tgtaaaacat cactttatct gatggtataa taaaggagac tgaattgttg

1981
gacataagtc atattcttta ggttgctcag ctctttcaaa gagcacaagc accaagaatg

2041
tctcaggtgt cctgggcact gtgaagtttt atttatttat ttatttattt atttgagacg

2101
gagtctcact ctgtcaccca ggctggagtg tagtgatgca atctcagctc gctgcaacct

2161
ctgcctccog ggttcaagtg attcccctgc ctcagcctct cgagtagctg gaattatagg

2221
cacgtgccac catgccgggc taattttttg tatttttagt agagacaggg tttcactgtg

2281
ttagccagga tggtctcgat ctcctgacct gatgatctgc ccgccttggc ctcccatagt

2341
gcbjggatta caggcgtgag ccaccgcgcc cggctggcac tgtgaagttt taaatgcttt

2401
gaatgtactg ttaatatata aatttgttga atggagtaac gaaggaaagc agctgaattt

2461
gcatgtgaca gaaaacaagt tgttacacgt ggaggatgca gcattatata cttactaata

2521
cgattagcaa ttttttttca gaatatatca gaatttcctt taaaaagtga agctacatat

2581
actgaactta tatccaccct acccctcgct caattaaatt atttctgata tgaaggaaag

2641
gattgcctat agctaaacag aagttttggc atagatatga ctgagtggta agggataatg

2701
agatatataa tattggttat agttttcttt tttccccaac ttttaagaaa agaaaatcta

2761
agaggaaata atgtttctaa atgttaaagt tcttcttgtt aaaattaaaa tgtagtgtga

2821
aaacatattc atggtggtaa tggtttaggg tggtggtatt tgaatttttt gttttttttt

2881
ttttactttt tgaaataaaa tgttttattt attataagaa attcatggtc ttcctcggta

2941
cttggtccat atgtatttct ttctcctcac cctcccctct tctaaccacc tcttttccag

3001
aatggatggt gatgccaatt ttgctcctag gttgtcctcc agccaccccc agcccagttt

3061
tcactttcta gctttgaaga ttgtccagtt ttccagctta gactagcatt gcctctacga

3121
tagttctagg tatctgtgaa gatttttttt tttcctgtag caatcatgaa atagctacta

3181
gtgctctgga cgattgtgct taatgccatt tgggtgtaag gcctcctaat ttcattagtc

3241
ttaccacttg bitttgcaag gatagctgtt tggagtcagc agtgcatgga acatgtgaac

3301
tgagacaaat ctgtttgaaa atctcaactt aagatttcaa atccactgtg tatactattt

3361
agcbgttaag tttctcagtc taagaagaac acgttttcct ctagaaataa gcttaaccca

3421
gtacctatgc atcgttcatt aatataatca gattacggcc tagatgtgga atttatttct

3481
gtttctattt tctccagctt tttaatacag ctcagacagt catatacagt tgtacacgat

3541
gtgcactgca caactctagg gtgctccatg catatagaca tatctgtatg tgacagccct

3601
aagtacaatg tggtagacac tctggacatt tggtaaataa gtatctacat cctcactctt

3661
ctctcattca cattggcctt ctggccagca ctatttctgg tttatttaat aaacaattct

3721
tgtcccccag aaattctgtg agtcttctga agatgccggg gaaagccagc cttcataaat

3781
cttttcaatg tcactaatga agacatgtca ctattgcaac aaaggaatac caggccatag

3841
taggctttca caactttttt ctgacagaat ttgtttcttt ctgctttatc ttccctgtgt

3901
actgtctttt tttatccacc ctctttctta attacactgg tagaagaata ttggtgggtg

3961
atggagtcat tcacattctg tgtaagacta gaatcagtcc aagatccaca ggaatgtggg

4021
atacttcttt catgagaagc cacatggctc acaagacttc tttacatttg tgttacttgc

4081
cttctcctga aattgtotct acagtgaatc aaataacaag gactgaggtg tattttccat

4141
atttaattcc aggaagcagt cccactcctt ctccctgccc gatttccagt tccaaagtca

4201
tgtacaggga agtccattga ctttgatgtt ggtcaaatgg cccagcaagc ttttgtccac

4261
ttttctgtca gacacagtcc ttggcacaaa agacatctga aatacttccc attaatttct

4321
tctttattta tgaccttgta gttaagtgtg ttgaattata tgcttctata cacatctgtt

4381
ttaatccagt tactcactta taactggtga ctgaaacttt tatatcacta tagcgtatta

4441
ttggtaccca ggatacaata gaatcctcaa tatcttacat cttcaatata gtacttcctt

4501
gtatgactta tttcttaaca taaaaatcct gttttagacc tgtggataaa cctttactat

4561
aaatcccaga gacaatttct ggaatgagaa tatagtattt gtccacacac atgattccat

4621
gtagaacttg aggtaataag atctgggact cccagataca tttattatta ccacaattgg

4681
atagaggtgc tacagaaata ggcacacaaa tgacagtaaa attgtttctg agaacatttc

4741
taggctcaac ttttttctac aacttaggat gaacagagag agtggaaact gtatataatt

4801
gggaatgtga ctgagatgag acaaagatga catggaagca tttcttcttc ccttgctttt

4861
ctggtggtaa gttcactctt ctgtcttcct tgccactagt tcttgcagtc cctaccaaga

4921
cactagggca ttatacagca aacacaccct gaggccccct gctactgcat catgaaagcc

4981
ttagctggtt gtgatgtcct agttcataaa gaatctgcct agtctctcat tagagctttc

5041
caatatttga caattcattc atttattttt ttcaacaggt atttattggg caccaatata

5101
tctaggcatt gatctagggg ctgggaatga agcaggaaat aagtctaggg gctgggaatg

5161
cagcaggaaa taagacaatg tttcaattct cttggaattt gcattccaag tgtgatgggt

5221
agaggcagac aatatgcaaa tgtgtaacat gtcaggtgtg ataaatgcta tgaagaaaat

5281
caagtagggg gagcggatac agtactgaat aaatcagagg agacctttct gattcagtta

5341
tgtctctaca gagtcctgaa ggtaataaga gagacagagg caaccatcag tgcagtggcc

5401
atggtgggcg cagcaagttg gcttcgatgt ctgggtatta gccagggagc cggtgcagct

5461
ggaggtgggg tgagtggagg ccagaagtgc agttgttgag gttggagaag tagccagaga

5521
agatcatgta aggtgtgact gtgctcccat aaaactttat ggacactaaa aattgaattt

5581
tatgtaattt tcctgcatca tgaaattaaa aaaaaaattg tttcaaccat tggaaaatgt

5641
aaaaaattgt tcttagctaa caggccatac aaaaacaggc tgcaggttag atttggccca

5701
tgggtcatag tttggcaatt gtgttatata taaattatta cactgtttta tcttcatcat

5761
ggtacacatc catacctgac atgttttatt tgcctgtgta tacatttatt gctttgtcac

5821
cgtctactag aatacaagtt ttttgagaaa aggagctctt aattgtcttg tttactgcag

5881
catcccaatc accagtgaaa agcctgtatg taatagagta gatactaaaa acagtatttg

5941
ttgactgatt gatggactag acctcaggat ttttagatac ccaggatcag gatatgaact

6001
actgcattaa atcatctcca acatctactc tcatgatggc ttgtctgact tcatgattta

6061
aaaaaaattc taaagcattt ttaaggcagt atattcaccc tgtgctattt tcctgtgggc

6121
ataggatagg gtttgtgtgg atgtatcaaa gacttctcca ctgtccttcc aggcacaagc

6181
catcctataa ggcgttccct tttaggagcc agaggtatag aaggaagtca tctgagccca

6241
ttattccagc ctgttggtaa cagaaagaga gatgagcaaa gtagcatttg gctgcacagg

6301
ggtctggaca aaacttcaac atcttgatgt tttccttcat ccctgagagc cttagaaatg

6361
ctacctatgc tttcatttta bittaggttg tttgtaaaat catggtaaat tatggcaaaa

6421
tactctggtc agatacttta tcaggttagg ccaggatatg ctgtgaaaac aaacaccccc

6481
gaaatcttgg tggttcataa acaacagaga cttatttatt gcttatacca catgaccagc

6541
ctggttcatc tggggtcaaa tccacatggg gatgaagctg gctgagtatc cgatcttgaa

6601
tgttaggaat cactatgaca gagggaggga gagcctgaga gcgcctcacc ctggcactta

6661
aattctctgg cccagaagtg acacatatta cttctagttg cagccccttg acccactgcc

6721
ccatctagcc acaaagggcc aggaagtgca atcccaccat gcgctcagaa ggcagagaga

6781
tggaaatatt tgacaaaccg tattaatgac tgtgacacat ggtgagttct tcacattggt

6841
gacttctaag tgcttctgaa cacacctttg actgtagaat gtcaaaaaca ttctcaattt

6901
tacagcagtg ctggaaaatg aattgtattg agacaacttg ggaggagtag aaggagatgg

6961
aataaaaaaa attcactgat ttctgtcatg tgtcatgcct cctttaatgc acggaagaac

7021
gtatactttg cttaggaaat cacattacca cattcagaac aactttagtg aagatgggaa

7081
acaaccatgg ctggtcaatg gggtaacgtg tgctgaagga agacaggttt atttctcagg

7141
aggcatcttc tccctgggaa aaggaaagac acatattcat ctcagtaaat atttgtggaa

7201
tgtctaccat gtgccaggca tatgagtgga aatgatgttt ttataaaata aagatgtctt

7261
aagtatttgc atgtcttact aacagtcagg gagttcaact tggccagtgg gaaggataat

7321
tttatgcctg aaactttagt aatgtaaatt tttatgctga ttctcttttt gtcattcact

7381
gagtattcct aagtaactat aacactcaca tattggagat aagtattggt ttcctgaaat

7441
ctaggtttgg ctaacattgc ttctggaaag agaaaataac abitgttgaa tgtccctatg

7501
gcaaattctt gctgttactt actgttccat tatggagagt gttagaaaga gtgtaatttt

7561
gattgaatga atatgctaaa aaaaacaccc taaataagaa actcacaaaa agaacagagt

7621
ggaatgaaaa agtgaaaaca actttgcaat ggtgtgcttc gtttataagt acattgtcac

7681
agcaagacta gggatgattg ggcatcttag agagtgcaga ggatgttgat aaggaagagg

7741
aagaggagat aagtggattt tgatatggga cactagatcc ttagggaaga aatgtgaaag

7801
agggtattct gggctgactg ccgctggcat agcaaggctg ctttgtagaa gggacaataa

7861
agttttgcat aaggatcctt tttcccatcc aatggattat gctatacttt agctggaata

7921
gggctgtagc agttagctat tgccacaata atgctgtgta acaaagcagt ccaaatttca

7981
gtggcttaaa acatcactac cttattctca cttatgtctc caagtcagct gggagtcaga

8041
ggattaaggc tcaaggctta ggtttggtgc aggtcagccc caggtgtctc tcatcctcct

8101
ttgatcagtg ggctagcagg agcatgtgct tgcaatgatg gtggaaatag aaaaacgtgc

8161
aatcatatgt gagtttcaag cctctccttg catcatgtct tgtaatgtcc tattggtcag

8221
tagggcbjgg aaatatatcc ctccctcaga gagtcaggag tggaaatgaa aatgttttta

8281
acaatagcct aatcaccata aaggctttgg gtggcacact gggcccttga tcttggagat

8341
cagtgataga ctgtaacaga cctcagaaac cccttggggt tattcagagc atacttctag

8401
agggtctggg gttgtcttgc cattcaagcc catcccacac ccatctgccc ccacatatcc

8461
taagcacagt tatgtcaagt gagaacagag gcatttgagt ggagcacaga tttcaaacac

8521
ataaaggcag ggcatggcca tctcccgcag tgctagatga tctggcbggg agaaaaccac

8581
aagcagtctt catcaaattg gaggatgtgg aggtcccagg catttagtcc cctagtatgt

8641
ccttaaaaaa cccagacagc catgcacaca cactcacaca aatgcacacg cacacacaca

8701
tacattcaca cacacactct tttcctgcat ttgtagttcc tttcctcagt ctaagtttaa

8761
ttaaacaact tggatttcat atatattcat ttaaatatag aattgcataa agaaaagagc

8821
caccagaacc accaatggta gcatgaggcc tctgaaatga aagatgagcc caccccaacc

8881
ttaaatggcc aggtttctgg atttcagaga agcaagatca gacccttggc aggttccatc

8941
tgagcagcca cagcagccat agctacagca ataattatta gcaagtgtgc gttctccctg

9001
ccctagttag tacaccctat accatcaggt gtcatctgtt ctagttaaag tcagaccgta

9061
ataacaaaac atcaaaatgt aaaatgtggg ttgttttttt ctttacacac ttctaaagac

9121
atttaaagcc tgagcagata ccttaaaatt catcttctat ctgaaaatac ctcctagaac

9181
cattttaaaa aggagatgga ggcaaggtgg agagaaaaag tttgtctttg gttgacactg

9241
ggaaagttgt cttttaaaaa attttttaat gtttatttac tatggagttg ccgtgtcttg

9301
ctcttttcaa gctcacctgt cojgcttcta aggaatatca ggggccctaa aacacagact

9361
tctaaacccc aacacatagg acacacctaa gtgtggaaag aaaggaaaga ggcaggaaag

9421
aaaggaaaga ggaaggaaag aaaggaatgc aacatttatt gtgtgcctac catatacctg

9481
accctttcct acatatgacc acatatgatc tcttcatgag ctttatgagg tgacctatta

9541
ttaacaatgc tgctttataa atgaggaaac caagccttaa ggaagtcaaa taccatatcc

9601
tcagtcaaat agctaaaaaa aaaaaaagaa aagaaaaaga aaaggtagtg cctggattca

9661
aagacagctt atttttttaa cttatagagt aaaatggatt ttttcccttt tggtgtgtag

9721
ttctatgaat tctaacacat gtatagattt atataaccac aaccataatt aggatacgga

9781
actattccat caccccccaa aaattcactt acgttatcct tttacagtca gaccttcctc

9841
ccagcctccc aacctctggc aatcactgat ctgttctcct tcactgtcgt tttgtatttt

9901
tggttcgctg tcattttggt tttttgggaa tgtcatataa atggaatcat acagtatgta

9961
gcagtttgag attggcttct ttcactcata ctgcctttga gattctacca gtgtcccagt

10021
agttcattcc tttttattgc tgagtagtat tacatcgatt gctgaaccgt tcacccattg

10081
aatgacacat aagttgtttc tagttttttg gctattgtga ataaagctac tacaaacatt

10141
catgtacatg tatttatgtg aacataaggc ttcatttatc aagggtaaaa tccccagaag

10201
taggactgtt gggtcatatg gtgagcatat gtttataaga aactgcaaac acattttcca

10261
gagtgttata ccattcaaag ccagttttga acaattcaaa tctatgcttt ttctttccag

10321
taagcbgttt ctccagacga cagagtggtt tactatatta ggcaaagctt catcttgggg

10381
aatgttattt ccaactgaga gctatgggag gcaaagtcac aaaccttcag ctcagactca

10441
ccaatctaac ttgatctggg aagatacctc gacaggtggg ggagggagaa catctgctga

10501
ggaaggccgg gagtggagtg agacattgct acttggaccc caaaaccagg aaaaatttgg

10561
tggttttggt tgagcttgaa ccatcaggtt aaacaggaaa tgcaaaatgc tcttccagtg

10621
aaacagaaga agctgctaag aggtagaggg aacatggaac tatttgtatt gcaaccgaat

10681
ccacctcccc aaacccactg caaagggaaa ttgctgactg caatgtccct gaactccagg

10741
gtgagtaaga agagaaccac gccccccagg gaacacttgt aaatttttaa gcaaatctag

10801
ggaaagttgt gtaaaatgtg tcccttccat aactcaccct aaagcttctg ggtattctaa

10861
atatacaaat tctattcatc acaccgtttt atcaccaagc ttcctgaagg catattgcca

10921
acacaatttg acaaagaaaa tagcaccaac agotttttaa agccttggaa ggatagtctc

10981
agacccatgg ctctctagag gtccagggat gaatctagca aagctggcct ccttttccat

11041
atatatagaa caagaggatt gttaatagca tgggattgga atggctcaag aaaagctttt

11101
tgaagctctt tgagaaaagt agccagggtc cccccttaaa ccttctttgc tgatggcctt

11161
acagctcaaa accagcattg gaaccggcta ggtactccca aaccaaagcc tcttccactt

11221
ggcatgtata tttatattct catatcttct ttcaaatacc tttcagtgtt gccttttgaa

11281
aagattataa tttgtacttt tttgttgaat tcagtaggtt aaagcagtac ctattatctt

11341
taattttatt ttgaaaaatt ggttggtttg gcttttgggg aatttgagag gcaatttagt

11401
ctgtcattta ggatggcatc atataaggca gccaacttca tcatgctatt tagcctgaaa

11461
agcgatattg ttgatcttca accttgaaaa agtcgtacag gttgggagct gacctgcaaa

11521
tggtcaggta tcttgagata ggaaaaggat ttacaaatcc aggtcagcaa gatactcata

11581
caaatatttt gaacccaagg tatacatcaa atagatttaa agactaagac tatttctgag

11641
catgcatcga ctgtttgaag actagtggac ttgtatgaag ttcaggagtt aacctgggtc

11701
ttgtaactta aaaacagcat ttctcatgcc ctaaattagt agtagagaga caatatagag

11761
agttcctata tagccctcac ctatcttcct ctaaggctaa cacctgggaa gttttttttt

11821
aaaaaatcct gatggcaaag ctgcagccca gacccaaaaa atgagaatct gtgagattta

11881
agattcgagc atcagtattt ctttgaagct tattcccagg tagattcaag aagaagccaa

11941
gattttgaat gcctgcttta ttattttttt ttttgtgaga gctttaatgg cacaaaatgt

12001
ttatagctac aagttataca tgtattgtaa attgtatata acgatacaaa gtgctaacta

12061
aatagatgga gaacgcataa ccactttggc tcagttaatc caataatttc cacaatgggt

12121
tcatgaaaaa cctcatctga ctggctaagt cttcaattct cattttttta gaatagtaaa

12181
tatttttact gcaatcacag gaacttgttg cgctttccaa tgtgcaagtt tctgcagttt

12241
tgctcttgat tctatttaca aatatcttaa gccagttttc atcaaacata tgaaaaatga

12301
agcctgcctt tttgtcccca aattgtaaat aggtgtaaat ctttttaagc atcaatctca

12361
caatttcaac agttaattgt tgaattctcc tttccaatac acgatgtttt cgttcaacac

12421
aaatctgggt agtagtaaaa tgttcatccc gtgtgttagg gctacagata catactacgt

12481
gctctcataa taaattttac tgttatgatg tattcatttt ttaagtaatt ttccataatt

12541
tcactgatgc tttaagaaaa agagcaacac tatgtttctt tttaacgttg aaagaaatca

12601
taaatatacc caggttcaat ggcgctactg atagaactgc tgctgaattt ggaatgagca

12661
caatgcacta gctgtaagaa gtcagttttg ggtaatgaat aattttactt ttccctcctg

12721
taataccaat ttcatactgt agcagtttat ctagtcagtt ctcctaactt tctgtccttt

12781
ccaattttat tcaggctttt caaaaatcag tgagccatca gatttacttt cttcccaaag

12841
aaattcaaat atgaatgctt gaaataaata ggttatagaa ggcaaatcaa gtgttatcag

12901
gtttaagatt aagacagaaa catggtctaa taaaaagatg tccaaaatta tctagacatc

12961
aaatgctaga aagaaaaaag aaaattactt gcaaaactat ttaggatata tcatctttct

13021
taaagattgc cagctatatt cttgaaaaaa agataaaaat tttcttgttt aacctgcatg

13081
ttattttcca ctataacatt aattttacaa atgttgatgt gagagagaag agttagatag

13141
tttctgcaaa ctggcaaacc tggctgtgat agtgttttta ttcaagttaa cctggtgcac

13201
tttatagatt gctagottta aaattaacag tgtgaacccc tgotttaaac ccttctcaaa

13261
gtgcagtcag ccaatcaaca gtattgccat cacctgggaa cttgttagac cccactttgt

13321
caaactcatt tcctggtatg acaatgaatc tggctacagc aacagggtgg tggacctcat

13381
ggtccacatg gcctccaagg agtaacaccc caggaccatc agccccagtg agagcacgag

13441
agaaagagag aggccctcag ctgcttggga atccctgcca cgctcagtcc ccaccacact

13501
gaggatctcc tctcctcaca atttccatgc agaccccctg aagagggaag ggcctaggga

13561
gccccacttt gtcatgtacc accaataaag ttccctgtac tcagccaaaa aaaaaagaaa

13621
gaaagaaaaa agaaaaagaa atgcagcatc ctgtcttgcc ccaaacccac tgcgtcagaa

13681
tctgcatttt aacaagatcc ccaggtatgc acattaagtt ttgagaggca gtactacata

13741
taaaatatgc aacagaccac acaaacctgg gcccaattgc tatttgtcag atacatgtat

13801
gtatttatta cttataaatt ccttcatcag atatgtatta cgtgcttatt actttaaaaa

13861
gatgaatctg acacatatcc taccctcaaa gagatctcag tctaggaagg gaaatacaat

13921
gtgttcataa ataatatagt ctaagttagg gacttcataa aatgcttgat ggaagaagtg

13981
gcatttattt tggacctgga atgagaactg aaagaagata ttcaaaagac aagtgatgta

14041
gtgatgtagt tttgaataca cgaataatct cagggttact ttttctatag cttttggtga

14101
atcaagttgt ttattcatac atttaataaa tatttattca gctcttacta ttgctataag

14161
acagatacca ttactgctca ggtggttttt acaacctagt ggggaagaca agcagataac

14221
aagaaatgac acaattcatt agtgttactg gtagcgttgt gaaggacaag gatggggtgc

14281
tagaaatcca tgtgacggac cagacctagg caggggtggg agttatggag gaggtttccc

14341
tgagtaggta acatctaagc tgagaaagat ttagttagac aaagagtgaa tggcattcca

14401
ggcaaaggaa acagcatgga ctaaggtcaa aacaagaaga aatgaacgaa agagcaagtt

14461
gataaaatgg atgtccaata atattccatt gttcaactat gcaacatttt tcattgcctc

14521
ccaaattgga tcaaagtagc ctggtcttca tgcctccagt ccttcctctt tttaaaaatt

14581
ttatacaact atattaatat agaatttaca tactataaaa tttcattcaa gtatattagg

14641
aaatttactg agttgtatag ctatcatcca tataaggtcc gttatgtccc tttgcaatga

14701
accctccatt ctcactccca gcctcaggca gccaataatc tattttctgt ctctaggggc

14761
tggaaactta ggattggaat tagttggttg tataataaat ttagcttatt agagaactgc

14821
tgaactcttt tccaaagcaa caatacaatt ttacagtttc atcagccttg tgtgagggtt

14881
cctgttgctc catatccatt acaacacttg gtattgtcag tccttttgtt tatagccatt

14941
ctactgggtg tgaagtggta tctcatttca ccagcccctc ttcctaactt atttgccaga

15001
ttccccactt ctaaacttgc tctatgccca accaaagtga accccttgct gttttttttt

15061
tcccctgagg ctcgttgata tccccaaatt atgcctttct tcattctttg aatgtgttac

15121
ttgactggat atgtattttt ggtgaaggag aggggctgga aattgagaga tgaaattggt

15181
aggagtacag aaggccgttg acttcctcac aacgtgggac acttccaagt ttctcctaca

15241
aaccccacca ctataccttt ccaaatatct tgcctgccat cttggtcacc cgtgacctaa

15301
attaatactt aggaagctat ggagatgctc atgcttcctc aggggagaat gctgtgtgaa

15361
cttagaaatt agcaaaaggg gaaatgacta cccttgaaat tgtaccacag aaaggagcat

15421
acattcaaat gatggtgaag tcttattaaa aagactttaa gcctcccaat ttagaagctg

15481
gottgtggta gccaagaaat tagagaatga tttgttattt aagagtgaaa ttgctagtag

15541
tcttgaatta attaccataa aaaagctgcc gctgtaataa aaagcagaga tctggtaacc

15601
ctgcttcatt cactttcttc ctcttgatga aaacctttta attattttga ttttgattag

15661
cacttccatc agaaaatagg aagaaattag gagcaattta cttggcaaag gtttagtaat

15721
taaaaccact gaaatcaatg gtttaagtat gtatttggga taaacacatt tttaattgtt

15781
atttttgtct tacccaagtg gataacataa agttcattat acaaaaatca accagtgcag

15841
aaagccgatt gggaacaaac aaccattctt gaaccctttg aaaatgtatg cccttgatga

15901
attacttgtc aggtttctac ttaagtttaa ttgttagtac ttccacttaa aatagcaaaa

15961
tgactgtctg caatttctgt tatttcaaac taggttttaa attctggggt tgaaagtaag

16021
cttaaataac tctgagtact tgagtaaaca ctgcattttt tatgatgagg caagttgtat

16081
gagccattta attactttaa ttcaatccag agatttgata ttttctcctg agttctcaca

16141
gttggatagt ttaaaaatat ttctaagatt gaattgaatc ctgtaagaac tataataaaa

16201
ccatacatct gcctgttttc tttctttctc tttctctcct ttcttttctt tctttctttc

16261
tctttctctc ctttctttct ttctctttct ctcctttctt tctttccttc ttttctttct

16321
ttctttcttt tctttctttc tttctttctt tcctttcttt cttctttctt tctttcttct

16381
ttcctttctt tctttctttc tttctttctt tctttctttc tttctttttc tttttctttc

16441
tttctttctt tctttctttt tcaagatcgt gctccattgc ccaggctgga gtgcaagtgg

16501
cgagatcatg gctcactgca accttgacct ccccaggctc aggtgattct cccacctcag

16561
tctcctgagt agcbjggagt acaggcatgc accagcatgt ctggctaatt tttgtatttt

16621
tagtagagac agggtctcac catgtttcca gtctgatctt gaactcttgg gctcaggcaa

16681
tcctcccacc tojgcttccc aaagtgctgg gattacaagt gtaagccacc atgcctggcc

16741
ttgtattttt ggataatatt gagtgaaatt tgcctcaata cataaaaatc ctttcaatat

16801
gcttcaactc taaaatcttt aaaaagctgc ttggtttcat tattttcacg tggaagcagc

16861
attgtcacaa agttttattt tgaagactga attgtatatg gagtactgtc caactagaag

16921
agaatgaata atcaggaaaa gagagactat tgacaaataa gacttaatgg agaagcattg

16981
aatttcaaag ctgccagaga cattagcaat tgttcagttt catctccaga tttcttagat

17041
gaagaagctg tggcaagcca atttcacaaa cccgatctat gatcctcatg ctccccactc

17101
ctctcactcc cacaattttg ccttgattca aactttatcg aaaagtgaga aatcacaggt

17161
atgagctcac tgagcttccc aggcagtctt gccatctaca aacccatgtc attctgtatt

17221
ttcctcttgt ttctgacagt gatcctctca tctagtcaca ctacatccac ttatctctgg

17281
cacttatgtc aaaacaaccc ctctaggtcc tgccttagct ctcctgcata tgctttttct

17341
ttcttcctgt ctgttgcctc tttcccccag cttataattc tcccgctttt attaaaaaca

17401
tgcacccaca gacacacact cacatctgga ttcccaagtg cgataacctt gtagattcat

17461
attttcagat cgttcttagt ccacagaata taaaattgat tgaatgatgg caaacatctg

17521
cagatgacaa tcatttacag aaatggcact aaagccatga agctgaagct gcaggactta

17581
tggatctggg ctagaagaca ggggccatca aaaatttagc ttcagttgga aatcggctct

17641
tttagtgcac tacatcagat ccatgaaaga ggaaggaaga gttactgctc attgctgcct

17701
ggagctgtga cttctatgaa attacttaac ggggcaaagg aggaagcaga tacttccttg

17761
caactaggac gtgagctgag ctgatocctg aatcataaat actcaacaag attcggattc

17821
aggacccagg gtattatggg gtacaaccat aaaacttcta aatgttggag aaagaataat

17881
gagaaagaaa aatgaatctc tgaatgaaaa tggaactact aaccaaaatt ccaaatcacg

17941
ttaatataat tattactaag aatgacagca acaaaatgaa taatcagtat atgtcatacc

18001
tataaagtta aaatctaaaa taatttgaag aaatacttaa aaatatttgc aaccctcaaa

18061
gagataaaga aataatattc ataaaattga aatgacaaac taggggcagg gcgcagtggc

18121
tcacgcctgt aatcccagca ctgtgggagg ccgaggtggg tggatcacaa agtcaggaga

18181
tcgagaccat cctggctaac acggtgaaac cctgtctcta ataaaaatac aaaaacaaaa

18241
ttagccgggc gtggtggtgg gcgcctgtag tcccagctac tcaggaggct gaggagggag

18301
aatggcgtga acccgggagg tggagcttgc agtgagccga gatcgcgcca ctgcactcta

18361
gcctgggcaa cagaatgaga ctgggtctca aaacaaacaa acaaacaaac aaacaaacta

18421
ggaagaatat acagaaatgt aacagaaagt agataggaag aagaatgaag tagaaatgct

18481
tgaaattaga aatacggtga ttgaaattaa aaccttaaca aagtaaactc tagactcaca

18541
acaattggag agttggtgat tggaaagatg aaccaattaa tttacccata acacattaga

18601
gagaggtgaa gaggaaaaaa tagctaaata taaaagcaca tttaagagac atgtaagatg

18661
attaaaagcc tccaacattt ttcaaaaaag agagtagagg caatattata ggtggaataa

18721
tgaaaatgat aatggctgag aatattaaag aattgagaat aaaaaagaca agtggcctca

18781
gattgaaact gccatgaagg tctctgtctc aaattctcaa ctctgctttt gtagtatgaa

18841
agcagccgta gacaataagt aaatgaatgg acatggctgt gtgtcaatac aacttgattt

18901
acaaaaacag gcaggcagca ggctaaatta ggcbgggagg tcatagtttg acagctcttg

18961
atctaaagaa taaccattgt tggccaggcg cagcggctca tgtctgtaat cacaacactt

19021
tgggcggcca aggcgagcag atcacttgag cccaggagtt caagaccagc ctgcgcaaca

19081
tggcgaaacc ccatctctac taaaagtaca aaaattagcc gggcatggtg gcaggctcct

19141
gtagtcccag ctacttagga ggctgaggca ggagaatcgc ttgaacctgg gaggctgagg

19201
ttgcagtgag cggagatggt gccactgcac tccagcctgg atgacagagc cagactcggt

19261
ctcgaaaata aataaagaat aacctttgtt tacattttca tgtatatgtc tccagatgtt

19321
cctcatatat ccatataagt atgtatatat gatgtacata agtgcataag taaaaataca

19381
taagtaattt taaaagaggt tatatcatag ctgaatcaca catgacttag accacacttg

19441
ctcttctgag tacccatttt tggacaactc tcagtgtcca ctagcatgtc taaaaaaaat

19501
ttctcctcct aaaatgctaa tgcatgatgt agattttaac tacagctttt gaggctcagt

19561
ggaggagagt gtacatcaca ctacccaatg caaagccttt taacagcccc ttttgctcat

19621
ctttgttttc cttcactgtt cctcgccctg cagcaggcag ctgacattca cctttccctt

19681
ccaccctcct ctctcagcac tggtcctttg cctcctccct catcccagct ctacaaatgg

19741
cctcagcctg catattccaa ccacccagca aaacaaacat ctagtaacta ccgggtcagc

19801
aagagaaaat cggaggccct agccatagat agatcacctt atcatttctc cagcacattc

19861
caggaaggat ctcaattcgt tctgtcccaa tatacctcta catcctttgt tttgatgatc

19921
acatagaatt cattgtatgc atatatcatt atttatataa ctaagccccc aattttgaac

19981
aagaggctac atactgaaaa tcttttatct accaagtctt ttttttctta caaacccatc

20041
caatacagtt gcactgtatc cgccaataca gttcatgcaa ctgtatggaa agcaaactct

20101
agaagagtat ttgatagctc cataagaata ttaaactctt atacttctag agcgtaaaac

20161
cccagaaaag tattttgtca gaaaaaaatc atgtttttga aatagtaggt tttaaaagaa

20221
aacaaagaga gttagaagta agaaaattca ggttatcagg ggcttgatat cttttttttg

20281
tgactgtagt caggttaccc aggcctttgt ggatcaattt ctcaaacaaa taacagagat

20341
gaaaacaact gtcagtagct actgtcacaa aaataatatg ataaacatct tttcgtttcc

20401
tatggctgcc ataactaatt atcacaaact tggtggctta aaataacaga aatgtatttt

20461
ctcacagctc cagagtccag aattccaaaa tggaagggtc agcaaggctg cacgccctca

20521
aaacactctt ggagagaatc ttttcttgct tcatccagct tctgatggct ctaggcaatc

20581
ccccgcttgt cactgcatca ctcoggtctc tgcccccatc ttcaaatgac cttcctctgt

20641
gtccctgtct tctcttctgt ctcttataag gacacttgtc attgtacagt atttagggtc

20701
cacatagata atccaggagg atctcatttt aagatcctta acttcattac atctgtacag

20761
atcctttgtc caaattaagg taatgttcac aggttctgtg ggttaggatg tggacatatc

20821
attttgaggc ccaccattca atgcactaca attttctttg taagtgttct gagaacccag

20881
gaagaataag taaatcctct gattcaatca aaaatgagca gaatgtaaac caaaaatact

20941
agaagatatc ctttttccta ggcactggca tacgtttcaa tagtatctct aattacagat

21001
gtatttacac ttctaagtgt cagaaatgaa gattattatg acaaatttaa aatttagtaa

21061
cttgttttta aactggtatt tttgtttttt taagcgatca tctcagtcca cattggaacg

21121
atctgaacag cagatcaggg ctgcttctag tttggaggaa ctacttcgaa ttactcactc

21181
tgaggactgg aagcbgtgga gatgcaggct gaggctcaaa agttttacca gtatggactc

21241
tcgctcagca tcccatcggt ccactaggtt tgcggcaact ttctatgaca ttgaaacact

21301
aaaaggtagg tgtgtggatg tggagacaaa ttctttctct ttattagata gtgacaaaca

21361
cacttacttt ctccaaaagt ctgcgtaggg cagacacgtg tcagagggag aatgaaagtc

21421
ggtctttgat ttccagtatt agtgcagaat cttgattttt taatgtttac ttcacagaga

21481
aatatattca atatgatttt gagataaaaa acacaaaaga acatctcaaa atatagaaat

21541
aaatttaact caaggatgtg ggggcaaaga aaacccagga agactattgt tctcaataga

21601
aaaacaatca tcaggtttac ttagaaaata aaacctgggg attcatccac aaggagtatt

21661
ctactgccat acatacatag acaaaaacca aagatggcca ggcatggtgg ctcatgcctg

21721
taatcccagc actttgggag gccaagaacg gcagatcgct tgagcccagg agtttgaaac

21781
cagcctgggc aacatgacga gaccccatct ctacaaaaaa atagaaaaaa atagctgaac

21841
attgtggtac gtgcctgtat tcccagctac ttgggaggct gaggtgggag gatcggctga

21901
gcccaggagg tcgaggctgc agtgagccat gatcatgcta ctgcactcca gcctgggcaa

21961
cagagcaaga tcctgtctca aaaaaaccac cccctccccg aaccaataga ttaggtatag

22021
cttttttttt tatttctgca aagttgtgtg attttttagt aaaagtgaaa agtaaaagtt

22081
agacactgag ttgtaatatt gggtactggt attgctagga gaataatgaa gggagaaaat

22141
tctcaagaca aaatgatcaa aactccagac tagaaaataa cataatttga aataaggata

22201
atgatcgttc cctagtaacg tatgaagatt ctttaaaaga aaatcaggcc aggtgtggtg

22261
gatgacacct gtaatcccag cactttggga ggttgaggca ggtggatcac ctgaggtcag

22321
gagttcgaga ccagcctgac caacatggtg aaaacccatc tctactaaaa atacaaaatt

22381
agccaggcat ggcggtgcat gcctgtaatc ccaactactt gggaggctga ggcaggagaa

22441
tcacttgaac ccaggaggcg gaggttgcag tgagccaaga ttgcaccatt gcactccaac

22501
ctgggcaaca agagtgaaac tccatcttaa aaaacaaaaa aacaaaacaa aacaaaacaa

22561
aaaaacaaag aaagaaagaa agaaaaccag tgtgagtagg tactgtcata atgaataaaa

22621
tgcttgtcaa gtaaagttct gtggtttctg attaggcact taattttttg atgtcatgtc

22681
aaaacaacac aagaagctgc tacagcattg ctgatctagc attctagatt tgattaacat

22741
gattacctgg taactgacta tatatatagc ataattcaaa ttaaccacta ggccaaaact

22801
atttttttct ttctacctaa aattgtattt gttttttccc atttgtaaaa agatgttggg

22861
gttgcacaga cctctgttgt tggcbgtggg gagagctgtg catagatggg gacatattct

22921
ttggtagcac cttgggcatg agtgtgaaga ggattcttag tgttcatgtg tatgactgtg

22981
tgtctaagtg agttgatgtg gtaggaacca tagcctcgag ctcacttcag acagaaattt

23041
gaagctctag atgtttctat gtggtgaatt aatatagcct tcatgagaac aaagggttgg

23101
cacctcatct agaggtcaaa ggccttaacc agattacctg actgaaggcc tgaggtgaac

23161
ctggagctat ttcatgaaca tgaacgttac cataaaacca agactaggtg atctaaaaaa

23221
agtcaatgac attgacattt tctaaggaga aaaccattaa aatatcacgg aatttgcaaa

23281
ccctatgaat ttatctcgta atttctaggg gatcatctga agttatttac taagttagaa

23341
gcagtcaata atgaaatcag catgttacac caattagaat ttgttatcaa ctctcccttg

23401
tggatttcaa ggtaatttcc tgaggcagag cagtcctgct gggaagcagt aaagaatagt

23461
agagttatga agcctttaat cagtgatgtt ggtcataatt gcatatgatt ttgattaaaa

23521
gcttaccact ccaatttcaa aacttagttt tataaaaaga gaaaaagcaa atggaaagca

23581
acctttaagt agaattttaa attgggaata ttttcatagg ttggtttctt gttttttcaa

23641
ggattcatga ttaattatag tgaattaaat aataaccata ataatactta attgagtaat

23701
ttatctctca bitgttcagc cttcaggctt tttatataaa tattaataat cagaaatttt

23761
taaaaaggtt tcttgggggc tgggcacagt ggctcacgcc tttaatccca gcactttggg

23821
aggctgaggt gggcggatca caaggttaag agatcaagac cagcctggcc aacatggtga

23881
aactccgtct ctactaaaaa tacaaaaatt agctgggcat ggtggcgcat acctgtaatc

23941
ccagctactt gggaggctga ggcaggagaa tcgcttgaac ccaggaggtg gaggttgcag

24001
tgagccgaga tcgcgccgct gcactccagc ctggcaacag agtgagaccc cgtctcaaaa

24061
aaaaaaaaaa aagtttctca ggatagaatg ttttattatg aggaaaaaaa taaaaaaaaa

24121
caaagtttag gtagactgtg tagtataatg cagtgctcca gacaactcat attatgtttt

24181
cagtgattga agaagcaaca tatgaaaaaa attggtatta agggatgaaa aaggagaaag

24241
gaatggagaa gatgttataa gggaataatt tagggactag ggtcacatct caaatggtaa

24301
tattgtatca gtatacttca agcagacgtt ttctctattc cttctattcc cctatatggg

24361
aattcaggat aatctcagga gagttcttga aaatgcagta aaaataaagg agagtttgcc

24421
tattgttgca taacacatta ccacaaaact tagctactta aaacaatatt tatctcagtt

24481
tctgtgggcc agaaatgctg acatggccta gatcagtttt tctgcttcag atgtctctgg

24541
aggctgcagt taagatgttg gcttgggctg caggcatctt agggcacagc tgaagcagag

24601
tgtgctttca agttcagtca gctgttgttt gcaggactca attcctcaca ggctgttgga

24661
ctgagggtct tagttcctcg ctggctattg gccagaggct gcctcaagtt ccttgtcgtg

24721
tggacctttc taacatggcg gcaaactaac acaagaactg aaaaccaaac accgcatgtt

24781
ctcactcata agtgggagtt gaacaatgag aacacatata cacaaggagg ggaacatcac

24841
aaaccagggc ctgttggtgg gtggggggca aagggaggga gagcattagg acaaatacct

24901
aatgcatgcg gggcttgaaa cctagatgac gggttgacgg gtgcagcaaa ccaccgtggc

24961
acatgcatac ctgtgtaaca aacctgcacg ttctgcacat gtatcccaga acttaaagta

25021
aaataagcta aaaaaaaaaa aaaaaaaaaa agcctgcaag tggagaagga ggagagagag

25081
agagagagtg tgtgtgagaa agtgagacag agtaagaaag aagggagctt gcaataagta

25141
gaaacaagac tgcaatcttt tttaacttca tcatggaagt ggtatcccat cacttttgct

25201
gtattctctt cataagaagc aagttactag gttcagctca cacacgaggg gaaggcattt

25261
acacaagggc atgactatca ggagatgggg accactgggg gttagtttca aagctgccta

25321
ccacaagaga ttttcaccag caccacaacc ccacacataa taaataaact ctacagttcc

25381
atggcaagct acaaggaagt ctttgtgttg tctttatcat aaaattgaat ctttccccca

25441
aaacacctgt agaaaggcta tgcagcatta agtatcaaag ggtcaaaatc taatttaaaa

25501
aataaattat gagagaaaag caagtactgt tttacaagaa agtatataat ttttttattc

25561
ccataggctt ctttttttgt taccttcaaa ttaactatgg tcaaaggatt gctcattcca

25621
gtaataagaa caggcttatt tcatcattta cataaatatc agtatcgggc acttgcaaat

25681
gagaaaactc tgatttgagt aaggattagt ttcacttcaa tttccattta tgcgtttgcc

25741
aagtttaaat cctactgtag ttacttaagc aaccaacaga aacatatttc ttgatgatgc

25801
taaaacctac ctacacctgg ctttaaagca gaagaaatgc tatccagctg tatcctataa

25861
attgcttgat aaataatatt tacatgttat ttctttacac gcttctattt acttccctat

25921
taaccagctt ctccagatgt attcagtgta attatgtaca ggacatggtg ttctacctca

25981
aagggaaata aaatacttat attctacaag gtatggtata aatgggaaag agcacagaga

26041
ttggttgtaa cttctctgca aacaatcttt ggttaaagga ctgacaaaaa atatccatct

26101
agtaaaagaa acaagcagta gaaatgtgaa aatgactgtg ttcagcataa ccctggcaca

26161
tgttggcaca ccaggaccat tccacctgct agccccagtg agctttcttt ctctctgcag

26221
ttatagatga agaatggcaa agaactcagt gcagccctag agaaacgtgc gtggaggtgg

26281
ccagtgagct ggggaagagt accaacacat tcttcaagcc cccttgtgtg aacgtgttcc

26341
gatgtggtgg ctgttgcaat gaagagagcc ttatctgtat gaacaccagc acctcgtaca

26401
tttccaaaca ggtataagga catcggcaag cctgccgtct ctaaagccct gatgataata

26461
gtgttgatag ctacaacaac cttgttgcta aacactgtac taaatgcttt atgtgcataa

26521
tcgcatttaa tctttgaaac aaatcaagag ggtattttat gctcctttat agatgaggaa

26581
actgaggctc agagaggtaa cttacttatc caagtttaca cggctgataa atagcagagc

26641
tgggattcaa acccaggtct gtgggaggcc agagcctgaa ctcttatcag ttattgtctc

26701
tctgatgcta tgatgtcaag actcagaaaa ccatatggaa gttactagga caggatgtta

26761
aaaggaatga agatagctga tggcaggttc tgtgttgctc aaatggagtg attgagaaaa

26821
atttaatgaa ggttgtgggc agaattgggg aaagagggat gggacagtga agcacctgaa

26881
gctagcaaaa agggtgagat ttocccaccc ttcgactgag gagacaaggg gagggagcag

26941
ttatgggaac ccagagggaa agcggagaag agggtttctg gactggccac tgtcaactct

27001
tagcctggca gggagtaggg gcaggggctg ggagaggcaa gagggtttat agatgtagcc

27061
catggagggc agcgtcctgg ggcacagagc ctgatgggga aggaagggga gaggatggtg

27121
tctctggagg ggcaaagaga gaatatctag cacaaaagac atttggaaat aattctgcag

27181
tccccatgaa agaaataatt cagccctctt catcttataa atttcccttt gcttagtagg

27241
taagttttcc tttctctggt taccatgttt ttaataaatg tcgcatatga gagcagtagt

27301
aacaaacttg ggaaagcaat actaaaaaac tgtacatcaa actacattat ttttggtatc

27361
bittgcaaat tctttgaatg ttgatatact tatttaattg tcagtttgcc tatatggttt

27421
attctccttt taactgcaaa aagaggtagt acaagaaaat tacatgcact gaatatatcc

27481
atgttaggta attttcttaa tgctgatttg ttttgttaat agatttactt atccttaatt

27541
ttgttcctcc accctctaaa atatccttta aactgcagag tttctttttc taaattcttt

27601
tagagaatct tggagcttgt gtgtatttta acctctacta tttgacaatt aggaaaaaaa

27661
aatgacccaa gtagggctaa gcatcaattc tgagtagaaa aaaagcttgc ataacgtaag

27721
agggtttagt tcatgatcat gtgattccct agagcatagc caaaaaattg tgcaagaaga

27781
tgaagtttat gcaaagtaaa cactacaaaa acactctcac tgagactcat ggaagttcca

27841
ttacatattg agatgtcaga ataaacacaa ccttaatgga ttgcttccac ttaatagata

27901
gttgagtact ttattttgac tgctgtactc aacaaatgat taatttcata caatgtactt

27961
aagtgtaagt gtacagcagt ttttcttcca aatatgcatt tttgaacatt ttaatagtag

28021
ttttttaaaa actatctctc gccccaaagt tatggactat ttggcaaacc acctcttaga

28081
aacaaagtga acaaatgaat actctatgta gtaaggacta catggaatgg tgattgaata

28141
gacaatgcat taaaatcaac ttcaaactca tccacacatc atagaaccac tcaagaaagt

28201
tgtgtaatct ctctgtacat ctgtttcttc acctgtaaga tggggataat aaaaacccac

28261
cccataatgt tgttataagg ggtaaatgag ttaacatgaa agcacttaca acagggcctg

28321
gcctacggaa agcgtagaaa gaatgatata catgttagct ataattattt gtttgggcat

28381
gatgatcttg tatcagtcag ctattaatac acagtgctac gtaacaaaca cactaaaact

28441
cagtggttcc aaacaacaat gatttactct cacttatgta tctgaggttc agttagttta

28501
gggtggattc agcbjggctt gactctaagc tgcagtgtga gtccaagtca acttctatgt

28561
ttcccatcgc ttggaccagc aagcctgccg gattatgttc ttttcatggc tatagcataa

28621
gtttgagaaa acaagcccca taaaacatgc acagttcaaa tttgtacttc tgtcatgtct

28681
gctaacatcc cactagccaa agaaagtgac atggccaaat aaaaagtcaa gagacaggaa

28741
actatatttc ttcaatagag atggtgtgag aagggatgaa taaatagttt gaataataat

28801
ctattctaat aaaatcctaa agaaactgca tagctttaat ctcatttaac ccttacgatt

28861
tacactcaaa tttaaagcag gagcagggat taacagtacc attttacaag agtatcaatg

28921
atcaaaaagt taaaagattt gaccaaactt aaacacttca taaagttaga tgagcctgtt

28981
tagttccatt cttaatggac aacttggcta aagtcattgc cgtaaatgac aaaggcaaaa

29041
attcagacta gaacaacttt aaaaatgata tataaaatta aaaaaatata ttgtggttat

29101
ctttctctgc tgtagctctt tgagatatca gtgcctttga catcagtacc tgaattagtg

29161
ccbittaaag ttgccaatca tacaggttgt aagtgottgc caacagoccc ccgccatcca

29221
tactcaatta tcagaagatc catccagatc cctgaagaag atcggtaagc acttttgttt

29281
ttttttttat actggattat gcttattttt gccttgccaa aactgtgtgt agaggatttt

29341
tcattaatgt agagttatca atttatcttc aaattattca tattttagct tctaacctga

29401
acctactggt aataactggc aaatacatat ttttattaga tgttagatat atattgtggt

29461
aggaccaaaa cgctcagtgg tatgagcttg tcatgtctac ttgtagacac gtttgttctt

29521
aatatgcata gtctactgca ggtgtaaaac cgctgtaacc tcaaatttag cacatgttcc

29581
agaacaagca ttaaataaaa cttatttcag gcbgtttgta tatttacatc ctgaaatgag

29641
agaaaacaaa gaagattcct ggggtcattg gggagtgaca aaactagcag cacgtgagtt

29701
ttgcaacttt ctaatctttc ccccttaaga ttaccaaatg gaaaaccctt attttaaatt

29761
aaaatgactt aaaattaatt tggctttgaa attctcttga gattaatttt gtgattattt

29821
ataagacaaa cgacaaaacc aaaggtaagg atcacttatt tgaagaaaaa aaaggattta

29881
atataaagaa acaagtaaag ggtaactgaa tgaaaagatc attagttaga tacttagact

29941
ttgcaaaagt aaagcaataa atatattgtg tgagtggcaa gtaaaagagt aagctggtga

30001
ttagttaaca ttgaaccaag aagacacctc ccgcctctct ccagcagaaa agaaaacttg

30061
tagaaaagca acatttattc tcaagatgtt cctgcbgttc tggccaatgc ttttatcttt

30121
attttaaaga aaataatctt aggggccggg cacggtggct cacacctgta atcccagcag

30181
tatgggaggc tgaggcgggc agatcacgag gtcaggagat tgagaccatc ctggctaaca

30241
cggtgcaact ccgtctctac taaaaatata aaaaaaaatt agccgggtgt ggtggtgggt

30301
gcctgtagtc ccagttactt gggaggctga ggcaggagaa tggcatgaac ctgggaggtg

30361
gagcttgcag tgagccgaga tcgcgccact gcactccagc ctgggcaaca gagggagact

30421
ccgtcaaaaa aaaaagaaaa gaaaataatc ttaggaggta tgttagaaca tatttaattt

30481
tcgtaaataa actgttgaca gctataattt gcatagtttt aacatatacc ttcttaagaa

30541
gattacaatt tccaaaatta cagtttagtt tctaaacatt tccacgtaga atatttataa

30601
ttacagaatc actatctagt aagatgcagt tcataaatac aaattaagct cctttaaaat

30661
cttttttttt tttgagacgg agtttcgctc ttgttgcccc ggctggagtg caatggcgag

30721
atctojgctc actgcaacct ccgcctccca ggttcaagtg attctcctgc ctcagccttc

30781
caagtagctg ggattacagg catgtgccgc cacgcccggc taattttgta tttttcagta

30841
gagatggggt ttctccatat tagtcaggct ggtctcgaac tcccgacctc aggtgatctg

30901
cccgcctcgg actcccaaag tgctgggatt acaggcgtga gccaccgcac ctggcccgct

30961
cctttaaaat cttaactctt ctcacatcct tatcattttg tggtgagaac atttgaaatt

31021
tactctctta gcaatttgga aatataaaat acattattat tattgactat agttaccatg

31081
ctgtgcaata gatctcaaaa ccttatttct ccaaactgag tataaaaagc aaaaaataaa

31141
tttaaaaaat cttaactatt atctactcag gaatttattt aatgttccaa agttttgatt

31201
atccttgaaa gcttttaaat ctggttcatt gttttctttt cctagcbgtt cccattccaa

31261
gaaactctgt cctattgaca tgctatggga tagcaacaaa tgtaaatgtg ttttgcagga

31321
ggaaaatcca cttgctggaa cagaaggtaa tgatagtagt agtaaaataa taacagtaat

31381
aataaaagta gcaacaatag cagcaaccgt tattgagtac ttagtatgac cagacaatgt

31441
tgtaaatott gtatatgttt taactcattt aattctcaca acaaccctgt aatgtactat

31501
tgttatttct ttttttacaa ttacaaaatg ggcacaccaa gatatcgagt aatttcctca

31561
aggtcacaca gctgagagtg atagaagtgg tcagattcca gaaccctctg taccataatc

31621
atatagtaag tccatcaatg catcactctg ctttttaatc tcaaagaaaa gcccagagtg

31681
gttggagcat cctgaaacac tgaaattgaa aggggatgtt aaacttgaat gaaagctgct

31741
tcagaactaa atactagtca actgcagttt actaatttat ttgtataaaa gtctcacagg

31801
aacataaagt aattttggac ttggtttctg tcagctgcat catatgaaaa cacgccagta

31861
atttgaaaaa agaaatggag aataagagaa aatttttctg gaattagggc aaagcaaaag

31921
caaaatatgg ctattggtct aaggggagct gggagcaaaa tgagatatag tcaaattgtc

31981
attgctcata atccgtaatt ctgtgacttt gggtgatgaa catttgcttg aaaatgaatg

32041
cattttaatg tattttccag agagctttac atggttccac caaaaaaaaa aaagaaagaa

32101
aaaaaaagtc acaagtagtc atgcagtttt aaccttgctt gttttaaact ataatctata

32161
agcaagaaca gtaagggcta aactctaaga aatctgtcct ataaactgta aatagcaacc

32221
tactctccat tcttctgcct ctcagcttcc ttctaaatgt tttcacgaaa gctcagccca

32281
gagcatgtgg ggaaatttaa tatttatgtg gtttaaatgc ccatgccgat cttgaatgtt

32341
ctttacaccc ttcccaccaa gtgttcagcc atcctctacc agaacataca tcagttattt

32401
ggagactcgc catccagtga ggcagcacca aggggtgggc acactcctgt tgttatactg

32461
aaatgaaatc tctctccaga acagaccaga ctgcccaatg gaatacaata agagtcatat

32521
atgtaactca cattttacat taaaaagata aaaagaaaca agtgaaattt atcttaatat

32581
attttattta atccaatcta tccaatgtac tatcatttca acatgcaatc aatataaaaa

32641
atttatgagc tagcctacat tctttgtgct aagtctttga aatccagtgt gtgttgtaca

32701
cttacagcac atctcaattt agactctcta tttcatgccc aatagtcaca tatggcccat

32761
agctaccttg ttggacagcc cagctcaaga gcatcaactc attagttcag gttttaccct

32821
atagaaccat gtaaaacaaa tctaattctt tctccatgtg actcatgttc taaaagtgtt

32881
agaaaatttt tgtggggttg gccgggaatg gtggctcatg cctgtaatcc tagcactttg

32941
ggaggccgag atgggaggat cacttgaggt tgggagtttg aaaaccagcc gggccggccg

33001
ggcgcggtgg ctcacgcctg tagtcccagc actttgggag gccgaggcgg gcggatcacg

33061
aggtcaggag attgagacca tcctggctaa aacggtgaaa ccccgtctct actaaaaata

33121
caaaaaaaaa attagccggg cgtagtggcg ggcgcctgta gtcccagcta cttgggaggc

33181
tgaggcagga gaatggcgtg aacccgggag gcggagcttg cagtgagccg agatcccgcc

33241
actgcactcc agcctgggca acagagcgag actccgtctc aaaaaaagaa aaaaaaaaaa

33301
aagaaaacca gccgggccaa catggcgaaa tcccatctct actactacta aaaaaaaaaa

33361
aaaaaaaaaa aaaaaaaaaa aaaaaatagc tgggcatggt gatgtgcgcc tgtagtccca

33421
gctactcagg aggctgaggc atgagaatct cttgaacctg ggaggcagag gttgcagtga

33481
gccgaggtca tgccaccgca ctcgggcctg gatgacagag tgagactctg cctccaaaaa

33541
aagaaagaaa gaaagaaaga gagaaagaga aaaagaaaag aaaagaaaga gagagagaga

33601
gaaagaaaga aagaaaagaa aagaaagaga gagaaagaaa gaaagaaaag aaagaaaaag

33661
aaaggaagga aggaaggata gaaagaaaga aagagaaaga aagtaagtta ctgtgggaag

33721
ggcaatatac ttagagctta aaggctctag ctgaggattt cctggcacaa agcctctgag

33781
acagttttgt acggaggagg tttgtaggca ggcacaaggc attaaagggt aaagagagag

33841
gcagcagacc acagcgcagt tgctaagagg catcagccta agccaatggg aagttgaagc

33901
tgggaacccc tgcgggggta agtcttaaat ctaggtgaag aggctgagcc ctgtagaccg

33961
ttcattggct gccttggaga ggggatgtag ccttaggaga ggcagcttat ttctgctgga

34021
gataattctt gggaaggcac tcagccagta cacgtgtgta gagggtggta agaagaatag

34081
ggaagaagag aagtgctgtt ctaagcagcg ggtatatgag cactcagggc tggaggtgag

34141
agaacatact ggaagaagtt cagcatggtg gggatataat gggtggggac ataatgggga

34201
aggggctggt tagatgtgag agaagaagct ggacaggctc acaggggcaa agcagaagga

34261
ccttgtaatt cttgcatggg agcttggatg tgatactaag gacaaaggga aaccacacaa

34321
ctggctaaag caggagagtg acagtaccca ttagaatttt aacaaaatca tatcagcaac

34381
agtgtagaag aggatgtgtt gactcggggc agggaaggag gcaggaaacc ttttgggaag

34441
ttgtagcaat gatgtaagtg agaggcgcag ggtggactgg atcacaattg tttctcattc

34501
tcatctccta taagtcccca atgtggatca agttcacatt catttctcca gtggccccat

34561
caaattgatg ggatttactg agcttactgc tcactatact ttttttccgc acatgtgact

34621
gttaagccaa ctgccttttc tacagtgact tctcttgccc agatgagcac atttaggtta

34681
gtgaatccaa gtctaattta attgagtctt gttagagtca ggtcattgct ctaaattgtt

34741
aaaacaaacg atatacacaa acacacacac acacaaaaga ataaattgag gaggtcccaa

34801
ttctgtattt taaaatactt aatatatccc ttccttcttg aagagagcta caatttcaag

34861
aatttatttt gaaaaaattc tatcagttta ttgataaaaa tggtaaaagg aacaaagctg

34921
agaacagaac atatcatcag actctctagg gacggaaatc aatacataat acttcaagat

34981
atcaccctca gctacttgct gttccaccac cagttctctt gcatccagtt tttgtttctt

35041
ttaacttggc tataaggatg tgagcacaga ctctgccaaa cagcctgctg aagttctgca

35101
aacaccttgt ggattgtgtt tccctgaaca accctgtcca acaatggcct tgggcctgtc

35161
tgaagtattc ttagtgaact tctgctgcca cctagtgatc attgcgaatt tttaaaaagc

35221
ctctttatcc tttaacaagt tactcttgtc ttaccccaaa gcggcatctg cctcactggc

35281
atatgactta cagagctcac attttccctc tccacaaagt tcaaaatgga gacttctcag

35341
atttagcctt ccagcaccca ttctcaaacg tcgtgcatta cagaaaagtt taaactataa

35401
agttgaaccg cacgagattc tcattttgat atgtcattaa agtcagatat tggcaagaac

35461
atatggttta acccaatggc ttggaatgct ggatgggatt cccagaagct ccatacatcg

35521
gcctgcttca ggaccctttt attacaccaa ataaacccaa caaacatcca tcgagtgcct

35581
attttatatc agaacaatga gacctgctcc ttctccttca ggacatttta cttaatgggg

35641
gaaacataca agtaaacaga caaatgtaat cagtgcaaga aagaatcgga cagcaatatg

35701
cacaggataa ggacacttag ctaaacctgc agacattggg aaagatgtca gggaaaaggg

35761
atggcagaag gaaagacaag gccaaaggca tgggactggg aggcactgga atatcagggc

35821
aacagaaagt gctgtcattt ggtataaatg gaacacacag gatatatgaa agcaagaaac

35881
agaagatgag tctgtgaggt tactatgatc cagttcatgg agggccttgt atgtcctggt

35941
gggaaaattg gtttttattg tgggaaggga accttttaat gcattcaaag cagtggaatg

36001
aagtgatttg gtttgcattt gttaatcatg tgaagaagaa taggttggag ggataaaact

36061
tgtggtggtg agatgagtga cagagcgaca gccatctaca aaagaaacac aaggtacaga

36121
ctgaattgtg ggagtggtag tggggatgga aaataaagaa caaatttaga gaggcagaac

36181
tgagtggaca tgatgctcag acttaccaga gcaggtgagt caagaatgat gtcaccattc

36241
cctaaatgag gcaaactggg agagaagcag atttggggag aaaactacta aacatgtacg

36301
tccctccaaa accttcaaga atgctaaagg gacagagtca agttcttcca aagtttctgt

36361
ctcttccatt tattttgcaa tgaatttcaa cttgttaatc agaaatggat ttggagtagt

36421
agctattcaa ttgttttata caccttctag aagaaatatt tgtcagatga gtatgtcaaa

36481
aacttctcag accctcccct ttacttgaat gtatcttcca gcagatgttg gtggaatcaa

36541
agttcattat tactcctata tcttttatac tagtgttatg atctgcagtg aggacatgca

36601
ttgctattgc tacgcctggc ctggaatgtc tgaggtgtat ttctacaaca ccaattattt

36661
tgtgtgtctc tccttttaat ctccaccaaa aaatggagac agctagattc ataaccctta

36721
gacatcctat attttattac taatacttgg ttgtggaagt ttgcattcta aacaagtcat

36781
caacataaaa atctctaaaa atattttatg aaaaatattc agcttatgat attttaaaaa

36841
tcacaaacct aagaaaacac acaaacctgt gtttgtattg tgaaatcaga ggttaatctt

36901
cctcaccctg tgaaaaaatt aggggcataa atctatagga aggagattgg gtgaatccaa

36961
gttacttacg gatgacataa aagatacaat caactttggt gatccaattg ccacactaca

37021
actatctgac caacacgttt ctgtttctct ttagaccact ctcatctcca ggaaccagct

37081
ctctgtgggc cacacatgat gtttgacgaa gatcgttgcg agtgtgtctg taaaacacca

37141
tgtcccaaag atctaatcca gcaccccaaa aactgcagtt gctttgagtg caaagaaagt

37201
ctggagacct gctgccagaa gcacaagcta tttcacccag acacctgcag gtaaatgcct

37261
tgagttgtct tgcctttact catgacattt aacgtagatg ccattttaat ttggtgggat

37321
tccttagtaa gctaattttt ccccttggtg cctgagtccc ttttggataa tagaacagag

37381
gtttagcagc taaggaataa gcaagagtat accgagtcat gattaatcat gaaaataaga

37441
aaatcaatcc tgcctgttat tatgtgtgta gagctttttt tttttagacg gagtctcgct

37501
ctgtctccag gctggagtgc agtggcgtga tctgggctca ctgcaacctc cgtctctctg

37561
gttcaaggga gtctcctgcc tcagcctccc aagtagctgg gattacaggc acgtgccacc

37621
acacccagct aatttttgta tttcagtaga gacggggttt caccatgttg gccaggatag

37681
tcttgatctc ctgacctcat gatccacccg tctojgcctc ccaaagtgct gggattacag

37741
gcatgagcca ccgcgcccac cojgggttta gagctcttaa acaacaatga aattggtaaa

37801
atttaagcag ttattaggat attgcttaat aataatattt taggaagggg aggtttcaga

37861
tcatcaacct gtttagttca atctctcatt gtttatgtct atatatgttt gtttttttct

37921
ttaatggagg gaatatcatt ggatttatat agcaagtaat ttattcatga atagaacact

37981
tggaggttac tgattcactt cagtagattt tgaatccatg tgggataacc atgcaggatt

38041
ttatactgac attttaaata catgtctgga aaacttaatc aaatcagagc agagttattc

38101
ttttgaatcc agtcattgat tctgaattct catctttatt ttcttttgca acagctgtga

38161
ggacagatgc ccctttcata ccagaccatg tgcaagtggc aaaacagcat gtgcaaagca

38221
ttgccgcttt ccaaaggaga aaagggctgc ccaggggccc cacagccgaa agaatccttg

38281
attcagcgtt ccaagttocc catocctgtc atttttaaca gcatgctgct ttgccaagtt

38341
gcbgtcactg tttttttccc aggtgttaaa aaaaaaatcc attttacaca gcaccacagt

38401
gaatccagac caaccttcca ttcacaccag ctaaggagtc cctggttcat tgatggatgt

38461
cttctagctg cagatgcctc tgcgcaccaa ggaatggaga ggaggggacc catgtaatcc

38521
ttttgtttag ttttgttttt gttttttggt gaatgagaaa ggtgtgctgg tcatggaatg

38581
gcaggtgtca tatgactgat tactcagagc agatgaggaa aactgtagtc tctgagtcct

38641
ttgctaatcg caactcttgt gaattattct gattcttttt tatgcagaat ttgattcgta

38701
tgatcagtac tgactttctg attactgtcc agcttatagt cttccagttt aatgaactac

38761
catctgatgt ttcatattta agtgtattta aagaaaataa acaccattat tcaagccata

38821
taa

In some embodiments of any of the vectors described herein, the vector includes a sequence encoding an antibody or antigen-binding antibody fragment that can bind specifically to VEGF. In some embodiments, an antibody or antigen-binding antibody fragment can include a human IgG Fc domain (e.g., SEQ ID NO: 113). In some embodiments, the sequence encoding an antibody or antigen-binding fragment can further include a sequence encoding a secretion signal sequence (e.g., SEQ ID NO: 92). In some embodiments of any of the vectors described herein, the vector comprises a sequence of a T2A peptidase (e.g., SEQ ID NO: 99).

In some embodiments, the antibody can be a humanized antibody, a chimeric antibody, or a multivalent antibody. In some embodiments, an antibody or an antigen-binding antibody fragment can be a scFv-Fc, a V_HH domain, a V_NARdomain, a (scFv)₂, a minibody, or a BiTE. In some embodiments, an antibody or an antigen-binding antibody fragment can be a DVD-Ig, and a dual-affinity re-targeting antibody (DART), a triomab, kih IgG with a common LC, a crossmab, an ortho-Fab IgG, a 2-in-1-IgG, IgG-ScFv, scFv₂-Fc, a bi-nanobody, tanden antibody, a DART-Fc, a scFv-HAS-scFv, DNL-Fab3, DAF (two-in-one or four-in-one), DutaMab, DT-IgG, knobs-in-holes common LC, knobs-in-holes assembly, charge pair antibody, Fab-arm exchange antibody, SEEDbody, Triomab, LUZ-Y, Fcab, k-body, orthogonal Fab, DVD-IgG, IgG(H)-scFv, scFv-(H)IgG, IgG(L)-scFv, scFv-(L)-IgG, IgG (L,H)-Fc, IgG(H)-V, V(H)-IgG, IgG(L)-V, V(L)-IgG, KIH IgG-scFab, 2scFv-IgG, IgG-2scFv, scFv4-Ig, Zybody, DVI-IgG, nanobody, nanobody-HSA, a diabody, a TandAb, scDiabody, scDiabody-CH3, Diabody-CH3, Triple Body, miniantibody, minibody, TriBi minibody, scFv-CH3 KIH, Fab-scFv, scFv-CH-CL-scFv, F(ab′)₂-scFV₂, scFv-KIH, Fab-scFv-Fc, tetravalent HCAb, scDiabody-Fc, diabody-Fc, tandem scFv-Fc, intrabody, dock and lock bispecific antibody, ImmTAC, HSAbody, scDiabody-HAS, tandem scFv, IgG-IgG, Cov-X-Body, and scFv1-PEG-scFv2.

Additional examples of an antibody or an antigen-binding antibody fragment include an Fv fragment, a Fab fragment, a F(ab′)₂fragment, and a Fab′ fragment.

Additional examples of an antibody or an antigen-binding antibody fragment include an antigen-binding fragment of an IgG (e.g., an antigen-binding fragment of IgG1, IgG2, IgG3, or IgG4) (e.g., an antigen-binding fragment of a human or humanized IgG, e.g., human or humanized IgG1, IgG2, IgG3, or IgG4); an antigen-binding fragment of an IgA (e.g., an antigen-binding fragment of IgA1 or IgA2) (e.g., an antigen-binding fragment of a human or humanized IgA, e.g., a human or humanized IgA1 or IgA2); an antigen-binding fragment of an IgD (e.g., an antigen-binding fragment of a human or humanized IgD); an antigen-binding fragment of an IgE (e.g., an antigen-binding fragment of a human or humanized IgE); or an antigen-binding fragment of an IgM (e.g., an antigen-binding fragment of a human or humanized IgM).

Any of the antibodies or antigen-binding antibody fragments described herein can bind specifically to VEGF.

A V_HH domain is a single monomeric variable antibody domain that can be found in camelids. A V_NARdomain is a single monomeric variable antibody domain that can be found in cartilaginous fish. Non-limiting aspects of V_HH domains and V_NARdomains are described in, e.g., Cromie et al., Curr Top. Med. Chem. 15:2543-2557, 2016; De Genst et al., Dev. Comp. Immunol. 30:187-198, 2006; De Meyer et al., Trends Biotechnol. 32:263-270, 2014; Kijanka et al., Nanomedicine 10:161-174, 2015; Kovaleva et al., Expert. Opin. Biol. Ther 14:1527-1539, 2014; Krah et al., Immunopharmacol. Immunotoxicol. 38:21-28, 2016; Mujic-Delic et al., Trends Pharmacol. Sci. 35:247-255, 2014; Muyldermans, J. Biotechnol. 74:277-302, 2001; Muyldermans et al., Trends Biochem. Sci. 26:230-235, 2001; Muyldermans, Ann. Rev. Biochem. 82:775-797, 2013; Rahbarizadeh et al., Immunol. Invest. 40:299-338, 2011; Van Audenhove et al., EBioMedicine 8:40-48, 2016; Van Bockstaele et al., Curr Opin. Investig. Drugs 10:1212-1224, 2009; Vincke et al., Methods Mol. Biol. 911:15-26, 2012; and Wesolowski et al., Med. Microbiol. Immunol. 198:157-174, 2009.

A “Fv” fragment includes a non-covalently-linked dimer of one heavy chain variable domain and one light chain variable domain.

A “Fab” fragment includes, the constant domain of the light chain and the first constant domain (CHI) of the heavy chain, in addition to the heavy and light chain variable domains of the Fv fragment.

A “F(ab′)₂” fragment includes two Fab fragments joined, near the hinge region, by disulfide bonds.

A “dual variable domain immunoglobulin” or “DVD-Ig” refers to multivalent and multispecific binding proteins as described, e.g., in DiGiammarino et al., Methods Mol. Biol. 899:145-156, 2012; Jakob et al., MABs 5:358-363, 2013; and U.S. Pat. Nos. 7,612,181; 8,258,268; 8,586,714; 8,716,450; 8,722,855; 8,735,546; and 8,822,645, each of which is incorporated by reference in its entirety.

DARTs are described in, e.g., Garber, Nature Reviews Drug Discovery 13:799-801, 2014.

Additional aspects of antibodies and antigen-binding antibody fragments are known in the art.

In some embodiments, any of the antibodies or antigen-binding antibody fragments described herein has a dissociation constant (K_D) of less than 1×10⁻⁵M (e.g., less than 0.5×10⁻⁵M, less than 1×10⁻⁶M, less than 0.5×10⁻⁶M, less than 1×10⁻⁷M, less than 0.5×10⁻⁷M, less than 1×10⁻⁸M, less than 0.5×10⁻⁸M, less than 1×10⁻⁹M, less than 0.5×10⁻⁹M, less than 1×10⁻¹⁰M, less than 0.5×10⁻¹¹M, less than 1×10⁻¹¹M, less than 0.5×10⁻¹¹M, or less than 1×10⁻¹²M), e.g., as measured in phosphate buffered saline using surface plasmon resonance (SPR) for a VEGF protein (e.g., any of the VEGF proteins described herein, e.g., one or more of mature human VEGF-A, mature human VEGF-B, mature human VEGF-C, and mature human VEGF-D).

In some embodiments, any of the antibodies or antigen-binding antibody fragments described herein has a K_Dof about 1×10⁻¹²M to about 1×10⁻⁵M, about 0.5×10⁻⁵M, about 1×10⁻⁶M, about 0.5×10⁻⁶M, about 1×10⁻⁷M, about 0.5×10⁻⁷M, about 1×10⁻⁸M, about 0.5×10⁻⁸M, about 1×10⁻⁹M, about 0.5×10⁻⁹M, about 1×10⁻¹⁰M, about 0.5×10⁻¹⁰M, about 1×10⁻¹¹M, or about 0.5×10⁻¹¹M (inclusive); about 0.5×10⁻¹¹M to about 1×10⁻⁵M, about 0.5×10⁻⁵M, about 1×10⁻⁶M, about 0.5×10⁻⁶M, about 1×10⁻⁷M, about 0.5×10⁻⁷M, about 1×10⁻⁸M, about 0.5×10⁻⁸M, about 1×10⁻⁹M, about 0.5×10⁻⁹M, about 1×10⁻¹⁰M, about 0.5×10⁻¹⁰M, or about 1×10⁻¹¹M (inclusive); about 1×10⁻¹¹M to about 1×10⁻⁵M, about 0.5×10⁻⁵M, about 1×10⁻⁶M, about 0.5×10⁻⁶M, about 1×10⁻⁷M, about 0.5×10⁻⁷M, about 1×10⁻⁸M, about 0.5×10⁻⁸M, about 1×10⁻⁹M, about 0.5×10⁻⁹M, about 1×10⁻¹⁰M, or about 0.5×10⁻¹⁰M (inclusive); about 0.5×10⁻¹⁰M to about 1×10⁻⁵M, about 0.5×10⁻⁵M, about 1×10⁻⁶M, about 0.5×10⁻⁶M, about 1×10⁻⁷M, about 0.5×10⁻⁷M, about 1×10⁻⁸M, about 0.5×10⁻⁸M, about 1×10⁻⁹M, about 0.5×10⁻⁹M, or about 1×10⁻¹⁰M (inclusive); about 1×10⁻¹⁰M to about 1×10⁻⁵M, about 0.5×10⁻⁵M, about 1×10⁻⁶M, about 0.5×10⁻⁶M, about 1×10⁻⁷M, about 0.5×10⁻⁷M, about 1×10⁻⁸M, about 0.5×10⁻⁸M, about 1×10⁻⁹M, or about 0.5×10⁻⁹M (inclusive); about 0.5×10⁻⁹M to about 1×10⁻⁵M, about 0.5×10⁻⁵M, about 1×10⁻⁶M, about 0.5×10⁻⁶M, about 1×10⁻⁷M, about 0.5×10⁻⁷M, about 1×10⁻⁸M, about 0.5×10⁻⁸M, or about 1×10⁻⁹M (inclusive); about 1×10⁻⁹M to about 1×10⁻⁵M, about 0.5×10⁻⁵M, about 1×10⁻⁶M, about 0.5×10⁻⁶M, about 1×10⁻⁷M, about 0.5×10⁻⁷M, about 1×10⁻⁸M, or about 0.5×10⁻⁸M (inclusive); about 0.5×10⁻⁸M to about 1×10⁻⁵M, about 0.5×10⁻⁵M, about 1×10⁻⁶M, about 0.5×10⁻⁶M, about 1×10⁻⁷M, about 0.5×10⁻⁷M, or about 1×10⁻⁸M (inclusive); about 1×10⁻⁸M to about 1×10⁻⁵M, about 0.5×10⁻⁵M, about 1×10⁻⁶M, about 0.5×10⁻⁶M, about 1×10⁻⁷M, or about 0.5×10⁻⁷M (inclusive); about 0.5×10⁻⁷M to about 1×10⁻⁵M, about 0.5×10⁻⁵M, about 1×10⁻⁶M, about 0.5×10⁻⁶M, or about 1×10⁻⁷M (inclusive); about 1×10⁻⁷M to about 1×10⁻⁵M, about 0.5×10⁻⁵M, about 1×10⁻⁶M, or about 0.5×10⁻⁶M (inclusive); about 0.5×10⁻⁶M to about 1×10⁻⁵M, about 0.5×10⁻⁵M, or about 1×10⁻⁶M (inclusive); about 1×10⁻⁶M to about 1×10⁻⁵M or about 0.5×10⁻⁵M (inclusive); or about 0.5×10⁻⁵M to about 1×10⁻⁵M (inclusive), e.g., as measured in phosphate buffered saline using surface plasmon resonance (SPR), for a VEGF protein (e.g., any of the VEGF proteins described herein, e.g., one or more of mature human VEGF-A, mature human VEGF-B, mature human VEGF-C, and mature human VEGF-D).

A variety of different methods known in the art can be used to determine the K_Dvalues of any of the antibodies or antigen-binding antibody fragments described herein (e.g., an electrophoretic mobility shift assay, a filter binding assay, surface plasmon resonance, and a biomolecular binding kinetics assay, etc.).

In some embodiments of any of the antibodies and/or antigen-binding antibody fragments described herein, the half-life of the antibody and/or the antigen-binding antibody fragment in a subject (e.g., a human) is decreased about 0.5-fold to about 4-fold (e.g., about 0.5-fold to about 3.5-fold, about 0.5-fold to about 3-fold, about 0.5-fold to about 2.5-fold, about 0.5-fold to about 2-fold, about 0.5-fold to about 1.5-fold, about 0.5-fold to about 1-fold, about 1-fold to about 4-fold, about 1-fold to about 3.5-fold, about 1-fold to about 3-fold, about 1-fold to about 2.5-fold, about 1-fold to about 2-fold, about 1.5-fold to about 4-fold, about 1.5-fold to about 3.5-fold, about 1.5-fold to about 3-fold, about 1.5-fold to about 2.5-fold, about 1.5-fold to about 2-fold, about 2-fold to about 4-fold, about 2-fold to about 3.5-fold, about 2-fold to about 3-fold, about 2-fold to about 2.5-fold, about 2.5-fold to about 4-fold, about 2.5-fold to about 3.5-fold, about 2.5-fold to about 3-fold, about 3-fold to about 4-fold, about 3-fold to about 3.5-fold, or about 3.5-fold to about 4-fold) as compared to the half-life of a control antibody and/or a control antigen-binding antibody fragment (e.g., any of the control antibodies and control antigen-binding antibody fragments described herein) in a similar subject. See, e.g., Leabman et al., MAbs. 5(6): 896-903, 2013. In some embodiments, an antibody or antigen-binding antibody fragment described herein has one or more amino acid substitutions in the Fc region that decrease its half-life in a mammal, and a control antibody lacks at least one (e.g., lacks all) of these one or more amino acid substiutions in the Fc region.

In some examples of any of the antibodies and antigen-binding fragments thereof described herein, the antibody and antigen-binding fragment can bind to a VEGF antigen (e.g., any of the exemplary VEGF proteins described herein, e.g., one or more of mature human VEGF-A, mature human VEGF-B, mature human VEGF-C, and mature human VEGF-D) (e.g., any of the binding affinities described herein).

In some embodiments described herein, an antibody or antigen-binding antibody fragment can decrease an activity of a VEGF (e.g., one or more of any of the exemplary VEGF proteins described herein, e.g., one or more of mature human VEGF-A, mature human VEGF-B, mature human VEGF-C, and mature human VEGF-D). In some embodiments, an antibody or antigen-binding antibody fragment can block a VEGF (e.g., one or more of any of the exemplary VEGF proteins described herein, e.g., one or more of mature human VEGF-A, mature human VEGF-B, mature human VEGF-C, and mature human VEGF-D) from binding to one or more of its receptors (e.g., one or more VEGF receptors) See, e.g., WO 1998/045331, U.S. Pat. No. 9,079,953, US 2015/0147317, US 2016/0289314, Plotkin et al., Otology & Neurotology 33: 1046-1052 (2012); and Ferrara et al. (2005) Biochem Biophys Res Commun 333(2): 328-335. In some embodiments, an antibody or antigen-binding antibody can decrease downstream signaling (e.g., signaling downstream of a VEGF receptor, e.g., one or more of any of the exemplary VEGF receptors described herein, e.g., one or more of human VEGFR-1 (SEQ ID NO: 111), human VEGFR-2 (SEQ ID NO: 112), and human VEGFR-3). In some embodiments, a decrease in an activity of a VEGF can be detected indirectly, e.g., through an increase in hearing (e.g., a 1% to about 400% increase (or any of the subranges of this range described herein) in hearing) or a decrease (e.g., a 1% to 99%, a 1% to 95%, a 1% to 90%, a 1% to 85%, a 1% to 80%, a 1% to 75%, a 1% to 70%, a 1% to 65%, a 1% to 60%, a 1% to 55%, a 1% to 50%, a 1% to 45%, a 1% to 40%, a 1% to 35%, a 1% to 30%, a 1% to 25%, a 1% to 20%, a 1% to 15%, a 1% to 10%, a 1% to 5%, a 5% to 99%, a 5% to 95%, a 5% to 90%, a 5% to 85%, a 5% to 80%, a 5% to 75%, a 5% to 70%, a 5% to 65%, a 5% to 60%, a 5% to 55%, a 5% to 50%, a 5% to 45%, a 5% to 40%, a 5% to 35%, a 5% to 30%, a 5% to 25%, a 5% to 20%, a 5% to 15%, a 5% to 10%, a 10% to 99%, a 10% to 95%, a 10% to 90%, a 10% to 85%, a 10% to 80%, a 10% to 75%, a 10% to 70%, a 10% to 65%, a 10% to 60%, a 10% to 55%, a 10% to 50%, a 10% to 45%, a 10% to 40%, a 10% to 35%, a 10% to 30%, a 10% to 25%, a 10% to 20%, a 10% to 15%, a 15% to 99%, a 15% to 95%, a 15% to 90%, a 15% to 85%, a 15% to 80%, a 15% to 75%, a 15% to 70%, a 15% to 65%, a 15% to 60%, a 15% to 55%, a 15% to 50%, a 15% to 45%, a 15% to 40%, a 15% to 35%, a 15% to 30%, a 15% to 25%, a 15% to 20%, a 20% to 99%, a 20% to 95%, a 20% to 90%, a 20% to 85%, a 20% to 80%, a 20% to 75%, a 20% to 70%, a 20% to 65%, a 20% to 60%, a 20% to 55%, a 20% to 50%, a 20% to 45%, a 20% to 40%, a 20% to 35%, a 20% to 30%, a 20% to 25%, a 25% to 99%, a 25% to 95%, a 25% to 90%, a 25% to 85%, a 25% to 80%, a 25% to 75%, a 25% to 70%, a 25% to 65%, a 25% to 60%, a 25% to 55%, a 25% to 50%, a 25% to 45%, a 25% to 40%, a 25% to 35%, a 25% to 30%, a 30% to 99%, a 30% to 95%, a 30% to 90%, a 30% to 85%, a 30% to 80%, a 30% to 75%, a 30% to 70%, a 30% to 65%, a 30% to 60%, a 30% to 55%, a 30% to 50%, a 30% to 45%, a 30% to 40%, a 30% to 35%, a 35% to 99%, a 35% to 95%, a 35% to 90%, a 35% to 85%, a 35% to 80%, a 35% to 75%, a 35% to 70%, a 35% to 65%, a 35% to 60%, a 35% to 55%, a 35% to 50%, a 35% to 45%, a 35% to 40%, a 40% to 99%, a 40% to 95%, a 40% to 90%, a 40% to 85%, a 40% to 80%, a 40% to 75%, a 40% to 70%, a 40% to 65%, a 40% to 60%, a 40% to 55%, a 40% to 50%, a 40% to 45%, a 45% to 99%, a 45% to 95%, a 45% to 90%, a 45% to 85%, a 45% to 80%, a 45% to 75%, a 45% to 70%, a 45% to 65%, a 45% to 60%, a 45% to 55%, a 45% to 50%, a 50% to 99%, a 50% to 95%, a 50% to 90%, a 50% to 85%, a 50% to 80%, a 50% to 75%, a 50% to 70%, a 50% to 65%, a 50% to 60%, a 50% to 55%, a 55% to 99%, a 55% to 95%, a 55% to 90%, a 55% to 85%, a 55% to 80%, a 55% to 75%, a 55% to 70%, a 55% to 65%, a 55% to 60%, a 60% to 99%, a 60% to 95%, a 60% to 90%, a 60% to 85%, a 60% to 80%, a 60% to 75%, a 60% to 70%, a 60% to 65%, a 65% to 99%, a 65% to 95%, a 65% to 90%, a 65% to 85%, a 65% to 80%, a 65% to 75%, a 65% to 70%, a 70% to 99%, a 70% to 95%, a 70% to 90%, a 70% to 85%, a 70% to 80%, a 70% to 75%, a 75% to 99%, a 75% to 95%, a 75% to 90%, a 75% to 85%, a 75% to 80%, a 80% to 99%, a 80% to 95%, a 80% to 90%, a 80% to 85%, a 85% to 99%, a 85% to 95%, a 85% to 90%, a 90% to 99%, a 90% to 95%, or a 95% to 99% decrease) in the size or the severity of one or more symptoms of an acoustic neuroma, vestibular schwannoma, or neurofibromatosis type II in a mammal as compared to the level of hearing or size of an acoustic neuroma, vestibular schwannoma, or neurofibromatosis type II in the mammal, respectively, before administration of any of the AAV vectors described herein. In some embodiments, a decrease in a VEGF activity can be detected in an in vitro assay.

In some embodiments, the antibody that specifically binds to a VEGF is bevacizumab (Avastatin®) (SEQ ID NO: 103) or an antigen-binding fragment thereof. Bevacizumab (full size antibody ˜150 kDa) inhibits all isoforms of VEGF-A. Bevacizumab received Food and Drug administration (FDA) approval in 2004 for colon cancer for intravenous (IV) dose of 4.0-7.5 mg/kg at 2-3 weeks (plasmatic half life 21 days), for intravetrial (IVT) dose 1.25 mg in 0.05 mL (half-life 5.6 days). Bevacizumab has a K_Dfor VEGF 165 (VEGF-A) of 58 pM. See, e.g., WO 2017/050825. The leader sequence of bevacizumab is SEQ ID NO: 104, the heavy chain variable domain of bevacizumab is SEQ ID NO: 105, the heavy chain constant region of bevacizumab is SEQ ID NO: 106, the light chain variable domain of devacizumab is SEQ ID NO: 107, and the light chain constant region of bevacizumab is SEQ ID NO: 108. An exemplary cDNA sequence encoding bevacizumab is SEQ ID NO: 109.

In some embodiments, the antibody that specifically binds to a VEGF is ranibizumab (Lucentis®) (SEQ ID NO: 95), or an antigen-binding fragment thereof. Ranibizumab (˜50 kDa) inhibits all isoforms of VEGF-A. Ranibizumab received FDA approval in 2006 for ocular use for intravenous (IV) dose of 4.0-7.5 mg/kg at 2-3 weeks (plasma half life of 0.5 days), for intravetrial (IVT) dose 0.5 mg in 0.05 ml (half-life of 3.2 days). Ranibizumab has a K_Dfor VEGF 165 (VEGF-A) of 46 pM. See, e.g., WO 2014/178078. The leader sequence of ranibizumab has a sequence of SEQ ID NO: 96, the heavy chain variable domain of ranibizumab has a sequence of SEQ ID NO: 97, the heavy chain constant region of ranibizumab has a sequence of SEQ ID NO: 98, the light chain variable domain of ranibizumab has a sequence of SEQ ID NO: 100, the light chain contant region of ranibizumab has a sequence of SEQ ID NO: 101. An exemplary cDNA sequence encoding ranibizumab is SEQ ID NO: 102.

In some embodiments, the antibody that specifically binds to VEGF is sevacizumab (APX003/SIM-BD0801), or an antigen-binding fragment thereof. In some embodiments, the antibody or antigen-binding fragment thereof that specifically binds to VEGF is aflibercept (SEQ ID NO: 110). An exemplary cDNA sequence encoding aflibercept is SEQ ID NO: 114.

In some embodiments of the antibodies that specifically bind to VEGF and antigen-binding fragments thereof described herein, the antibody or antigen-binding fragments thereof includes a variable light chain domain that is or includes a sequence that is at least 80% identical (e.g., at least 82%, at least 84%, at least 86%, at least 88%, at least 90%, at least 92%, at least 94%, at least 96%, at least 98%, or at least 99%) identical to the variable light chain domain of bevacizumab, and/or includes a variable heavy chain domain that is or includes a sequence that is at least 80% identical (e.g., at least 82%, at least 84%, at least 86%, at least 88%, at least 90%, at least 92%, at least 94%, at least 96%, at least 98%, or at least 99%) identical to the variable heavy chain domain of bevacizumab.

In some embodiments of the antibodies that specifically bind to VEGF and antigen-binding fragments thereof described herein, the antibody or antigen-binding fragments thereof includes a variable light chain domain that is or includes the variable light chain domain of bevacizumab, and/or a variable heavy chain domain that is or includes the variable heavy chain domain of bevacizumab. In some embodiments of the antibodies that specifically bind to VEGF and antigen-binding fragments thereof described herein, the antibody or antigen-binding fragments thereof includes a variable light chain domain that is or includes the sequence of variable light chain domain of bevacizumab, except that it includes one, two, three, four, five, six, seven, eight, nine, ten, eleven, twelve, thirteen, fourteen, or fifteen amino acid substitutions, and/or includes a variable heavy chain domain that is or includes the sequence of variable heavy chain of bevacizumab, except that it includes one, two, three, four, five, six, seven, eight, nine, ten, eleven, twelve, thirteen, fourteen, or fifteen amino acid substitutions. In some embodiments the first antigen-binding domain includes the three CDRs in the light chain variable domain of bevacizumab, and/or the three CDRs in the heavy chain variable domain of bevacizumab.

In some embodiments of the antibodies that specifically bind to VEGF and antigen-binding fragments thereof described herein, the antibody or antigen-binding fragments thereof includes a variable light chain domain that is or includes a sequence that is at least 80% identical (e.g., at least 82%, at least 84%, at least 86%, at least 88%, at least 90%, at least 92%, at least 94%, at least 96%, at least 98%, or at least 99%) identical to the variable light chain domain of ranibizumab, and/or includes a variable heavy chain domain that is or includes a sequence that is at least 80% identical (e.g., at least 82%, at least 84%, at least 86%, at least 88%, at least 90%, at least 92%, at least 94%, at least 96%, at least 98%, or at least 99%) identical to the variable heavy chain domain of ranibizumab.

In some embodiments of the antibodies that specifically bind to VEGF and antigen-binding fragments thereof described herein, the antibody or antigen-binding fragments thereof includes a variable light chain domain that is or includes the variable light chain domain of ranibizumab, and/or a variable heavy chain domain that is or includes the variable heavy chain domain of ranibizumab. In some embodiments of the antibodies that specifically bind to VEGF and antigen-binding fragments thereof described herein, the antibody or antigen-binding fragments thereof includes a variable light chain domain that is or includes the sequence of variable light chain domain of ranibizumab, except that it includes one, two, three, four, five, six, seven, eight, nine, ten, eleven, twelve, thirteen, fourteen, or fifteen amino acid substitutions, and/or includes a variable heavy chain domain that is or includes the sequence of variable heavy chain of ranibizumab, except that it includes one, two, three, four, five, six, seven, eight, nine, ten, eleven, twelve, thirteen, fourteen, or fifteen amino acid substitutions. In some embodiments the first antigen-binding domain includes the three CDRs in the light chain variable domain of ranibizumab, and/or the three CDRs in the heavy chain variable domain of ranibizumab.

Vectors

The compositions provided herein include at least two (e.g., two, three, four, five, or six) nucleic acid vectors, where: each of the at least two different vectors includes a coding sequence that encodes a different portion of a target protein (e.g., a supporting cell target protein or a hair cell target protein), each of the encoded portions being at least 30 amino acids (e.g., about 30 amino acids to about 800 amino acids, about 30 amino acids to about 750 amino acids, about 30 amino acids to about 700 amino acids, about 30 amino acids to about 650 amino acids, about 30 amino acids to about 600 amino acids, about 30 amino acids to about 550 amino acids, about 30 amino acids to about 500 amino acids, about 30 amino acids to about 450 amino acids, about 30 amino acids to about 400 amino acids, about 30 amino acids to about 350 amino acids, about 30 amino acids to about 300 amino acids, about 30 amino acids to about 250 amino acids, about 30 amino acids to about 200 amino acids, about 30 amino acids to about 150 amino acids, about 30 amino acids to about 100 amino acids, about 30 amino acids to about 50 amino acids, about 50 amino acids to about 800 amino acids, about 50 amino acids to about 750 amino acids, about 50 amino acids to about 700 amino acids, about 50 amino acids to about 650 amino acids, about 50 amino acids to about 600 amino acids, about 50 amino acids to about 550 amino acids, about 50 amino acids to about 500 amino acids, about 50 amino acids to about 450 amino acids, about 50 amino acids to about 400 amino acids, about 50 amino acids to about 350 amino acids, about 50 amino acids to about 300 amino acids, about 50 amino acids to about 250 amino acids, about 50 amino acids to about 200 amino acids, about 50 amino acids to about 150 amino acids, about 50 amino acids to about 100 amino acids, about 100 amino acids to about 1600 amino acids, about 100 amino acids to about 800 amino acids, about 100 amino acids to about 750 amino acids, about 100 amino acids to about 700 amino acids, about 100 amino acids to about 650 amino acids, about 100 amino acids to about 600 amino acids, about 100 amino acids to about 550 amino acids, about 100 amino acids to about 500 amino acids, about 100 amino acids to about 450 amino acids, about 100 amino acids to about 400 amino acids, about 100 amino acids to about 350 amino acids, about 100 amino acids to about 300 amino acids, about 100 amino acids to about 250 amino acids, about 100 amino acids to about 200 amino acids, about 100 amino acids to about 150 amino acids, about 150 amino acids to about 800 amino acids, about 150 amino acids to about 750 amino acids, about 150 amino acids to about 700 amino acids, about 150 amino acids to about 650 amino acids, about 150 amino acids to about 600 amino acids, about 150 amino acids to about 550 amino acids, about 150 amino acids to about 500 amino acids, about 150 amino acids to about 450 amino acids, about 150 amino acids to about 400 amino acids, about 150 amino acids to about 350 amino acids, about 150 amino acids to about 300 amino acids, about 150 amino acids to about 250 amino acids, about 150 amino acids to about 200 amino acids, about 200 amino acids to about 800 amino acids, about 200 amino acids to about 750 amino acids, about 200 amino acids to about 700 amino acids, about 200 amino acids to about 650 amino acids, about 200 amino acids to about 600 amino acids, about 200 amino acids to about 550 amino acids, about 200 amino acids to about 500 amino acids, about 200 amino acids to about 450 amino acids, about 200 amino acids to about 400 amino acids, about 200 amino acids to about 350 amino acids, about 200 amino acids to about 300 amino acids, about 200 amino acids to about 250 amino acids, about 250 amino acids to about 800 amino acids, about 250 amino acids to about 750 amino acids, about 250 amino acids to about 700 amino acids, about 250 amino acids to about 650 amino acids, about 250 amino acids to about 600 amino acids, about 250 amino acids to about 550 amino acids, about 250 amino acids to about 500 amino acids, about 250 amino acids to about 450 amino acids, about 250 amino acids to about 400 amino acids, about 250 amino acids to about 350 amino acids, about 250 amino acids to about 300 amino acids, about 300 amino acids to about 800 amino acids, about 300 amino acids to about 750 amino acids, about 300 amino acids to about 700 amino acids, about 300 amino acids to about 650 amino acids, about 300 amino acids to about 600 amino acids, about 300 amino acids to about 550 amino acids, about 300 amino acids to about 500 amino acids, about 300 amino acids to about 450 amino acids, about 300 amino acids to about 400 amino acids, about 300 amino acids to about 350 amino acids, about 350 amino acids to about 800 amino acids, about 350 amino acids to about 750 amino acids, about 350 amino acids to about 700 amino acids, about 350 amino acids to about 650 amino acids, about 350 amino acids to about 600 amino acids, about 350 amino acids to about 550 amino acids, about 350 amino acids to about 500 amino acids, about 350 amino acids to about 450 amino acids, about 350 amino acids to about 400 amino acids, about 400 amino acids to about 800 amino acids, about 400 amino acids to about 750 amino acids, about 400 amino acids to about 700 amino acids, about 400 amino acids to about 650 amino acids, about 400 amino acids to about 600 amino acids, about 400 amino acids to about 550 amino acids, about 400 amino acids to about 500 amino acids, about 400 amino acids to about 450 amino acids, about 450 amino acids to about 800 amino acids, about 450 amino acids to about 750 amino acids, about 450 amino acids to about 700 amino acids, about 450 amino acids to about 650 amino acids, about 450 amino acids to about 600 amino acids, about 450 amino acids to about 550 amino acids, about 450 amino acids to about 500 amino acids, about 500 amino acids to about 800 amino acids, about 500 amino acids to about 750 amino acids, about 500 amino acids to about 700 amino acids, about 500 amino acids to about 650 amino acids, about 500 amino acids to about 600 amino acids, about 500 amino acids to about 550 amino acids, about 550 amino acids to about 800 amino acids, about 550 amino acids to about 750 amino acids, about 550 amino acids to about 700 amino acids, about 550 amino acids to about 650 amino acids, about 550 amino acids to about 600 amino acids, about 600 amino acids to about 800 amino acids, about 600 amino acids to about 750 amino acids, about 600 amino acids to about 700 amino acids, about 600 amino acids to about 650 amino acids, about 650 amino acids to about 800 amino acids, about 650 amino acids to about 750 amino acids, about 650 amino acids to about 700 amino acids, about 700 amino acids to about 800 amino acids, about 700 amino acids to about 750 amino acids, or about 750 amino acids to about 800 amino acids), where the amino acid sequence of each of the encoded portions may optionally partially overlap with the amino acid sequence of a different one of the encoded portions; no single vector of the at least two different vectors encodes the active target protein (e.g., an active supporting cell target protein (e.g., a full-length supporting cell target protein (e.g., a full-length wildtype supporting cell target protein)) or an active hair cell target protein (e.g., a full-length hair cell target protein (e.g., a full-length wildtype hair cell target protein)); and, when introduced into a primate cell, the at least two different vectors undergo homologous recombination with each other, where the recombined nucleic acid encodes an active target protein (e.g., an active supporting cell target protein (e.g., a full-length supporting cell target protein) or an active hair cell target protein (e.g., a full-length hair cell target protein). In some embodiments, one of the nucleic acid vectors can include a coding sequence that encodes a portion of a target protein (e.g., a supporting cell target protein or a hair cell target protein), where the encoded portion is, e.g., about 30 amino acids to about 800 amino acids, about 30 amino acids to about 750 amino acids, about 30 amino acids to about 700 amino acids, about 30 amino acids to about 650 amino acids, about 30 amino acids to about 600 amino acids, about 30 amino acids to about 550 amino acids, about 30 amino acids to about 500 amino acids, about 30 amino acids to about 450 amino acids, about 30 amino acids to about 400 amino acids, about 30 amino acids to about 350 amino acids, about 30 amino acids to about 300 amino acids, about 30 amino acids to about 250 amino acids, about 30 amino acids to about 200 amino acids, about 30 amino acids to about 150 amino acids, about 30 amino acids to about 100 amino acids, about 30 amino acids to about 50 amino acids, about 50 amino acids to about 800 amino acids, about 50 amino acids to about 750 amino acids, about 50 amino acids to about 700 amino acids, about 50 amino acids to about 650 amino acids, about 50 amino acids to about 600 amino acids, about 50 amino acids to about 550 amino acids, about 50 amino acids to about 500 amino acids, about 50 amino acids to about 450 amino acids, about 50 amino acids to about 400 amino acids, about 50 amino acids to about 350 amino acids, about 50 amino acids to about 300 amino acids, about 50 amino acids to about 250 amino acids, about 50 amino acids to about 200 amino acids, about 50 amino acids to about 150 amino acids, about 50 amino acids to about 100 amino acids, about 100 amino acids to about 1600 amino acids, about 100 amino acids to about 800 amino acids, about 100 amino acids to about 750 amino acids, about 100 amino acids to about 700 amino acids, about 100 amino acids to about 650 amino acids, about 100 amino acids to about 600 amino acids, about 100 amino acids to about 550 amino acids, about 100 amino acids to about 500 amino acids, about 100 amino acids to about 450 amino acids, about 100 amino acids to about 400 amino acids, about 100 amino acids to about 350 amino acids, about 100 amino acids to about 300 amino acids, about 100 amino acids to about 250 amino acids, about 100 amino acids to about 200 amino acids, about 100 amino acids to about 150 amino acids, about 150 amino acids to about 800 amino acids, about 150 amino acids to about 750 amino acids, about 150 amino acids to about 700 amino acids, about 150 amino acids to about 650 amino acids, about 150 amino acids to about 600 amino acids, about 150 amino acids to about 550 amino acids, about 150 amino acids to about 500 amino acids, about 150 amino acids to about 450 amino acids, about 150 amino acids to about 400 amino acids, about 150 amino acids to about 350 amino acids, about 150 amino acids to about 300 amino acids, about 150 amino acids to about 250 amino acids, about 150 amino acids to about 200 amino acids, about 200 amino acids to about 800 amino acids, about 200 amino acids to about 750 amino acids, about 200 amino acids to about 700 amino acids, about 200 amino acids to about 650 amino acids, about 200 amino acids to about 600 amino acids, about 200 amino acids to about 550 amino acids, about 200 amino acids to about 500 amino acids, about 200 amino acids to about 450 amino acids, about 200 amino acids to about 400 amino acids, about 200 amino acids to about 350 amino acids, about 200 amino acids to about 300 amino acids, about 200 amino acids to about 250 amino acids, about 250 amino acids to about 800 amino acids, about 250 amino acids to about 750 amino acids, about 250 amino acids to about 700 amino acids, about 250 amino acids to about 650 amino acids, about 250 amino acids to about 600 amino acids, about 250 amino acids to about 550 amino acids, about 250 amino acids to about 500 amino acids, about 250 amino acids to about 450 amino acids, about 250 amino acids to about 400 amino acids, about 250 amino acids to about 350 amino acids, about 250 amino acids to about 300 amino acids, about 300 amino acids to about 800 amino acids, about 300 amino acids to about 750 amino acids, about 300 amino acids to about 700 amino acids, about 300 amino acids to about 650 amino acids, about 300 amino acids to about 600 amino acids, about 300 amino acids to about 550 amino acids, about 300 amino acids to about 500 amino acids, about 300 amino acids to about 450 amino acids, about 300 amino acids to about 400 amino acids, about 300 amino acids to about 350 amino acids, about 350 amino acids to about 800 amino acids, about 350 amino acids to about 750 amino acids, about 350 amino acids to about 700 amino acids, about 350 amino acids to about 650 amino acids, about 350 amino acids to about 600 amino acids, about 350 amino acids to about 550 amino acids, about 350 amino acids to about 500 amino acids, about 350 amino acids to about 450 amino acids, about 350 amino acids to about 400 amino acids, about 400 amino acids to about 800 amino acids, about 400 amino acids to about 750 amino acids, about 400 amino acids to about 700 amino acids, about 400 amino acids to about 650 amino acids, about 400 amino acids to about 600 amino acids, about 400 amino acids to about 550 amino acids, about 400 amino acids to about 500 amino acids, about 400 amino acids to about 450 amino acids, about 450 amino acids to about 800 amino acids, about 450 amino acids to about 750 amino acids, about 450 amino acids to about 700 amino acids, about 450 amino acids to about 650 amino acids, about 450 amino acids to about 600 amino acids, about 450 amino acids to about 550 amino acids, about 450 amino acids to about 500 amino acids, about 500 amino acids to about 800 amino acids, about 500 amino acids to about 750 amino acids, about 500 amino acids to about 700 amino acids, about 500 amino acids to about 650 amino acids, about 500 amino acids to about 600 amino acids, about 500 amino acids to about 550 amino acids, about 550 amino acids to about 800 amino acids, about 550 amino acids to about 750 amino acids, about 550 amino acids to about 700 amino acids, about 550 amino acids to about 650 amino acids, about 550 amino acids to about 600 amino acids, about 600 amino acids to about 800 amino acids, about 600 amino acids to about 750 amino acids, about 600 amino acids to about 700 amino acids, about 600 amino acids to about 650 amino acids, about 650 amino acids to about 800 amino acids, about 650 amino acids to about 750 amino acids, about 650 amino acids to about 700 amino acids, about 700 amino acids to about 800 amino acids, about 700 amino acids to about 750 amino acids, or about 750 amino acids to about 800 amino acids in length.

In some embodiments of these compositions, at least one of the coding sequences includes a nucleotide sequence spanning two neighboring exons of target genomic DNA (e.g., supporting cell target genomic DNA or hair cell target genomic DNA), and lacks the intronic sequence that naturally occurs between the two neighboring exons.

In some embodiments, the amino acid sequence of none of the encoded portions overlaps even in part with the amino acid sequence of a different one of the encoded portions. In some embodiments, the amino acid sequence of one or more of the encoded portions partially overlaps with the amino acid sequence of a different one of the encoded portions. In some embodiments, the amino acid sequence of each of the encoded portions partially overlaps with the amino acid sequence of a different one of the encoded portions.

In some embodiments, the overlapping amino acid sequence is between about 30 amino acid residues to about 800 amino acids (e.g., or any of the subranges of this range described herein) in length.

In some examples, the vectors include two different vectors, each of which includes a different segment of an intron, where the intron includes the nucleotide sequence of an intron that is present in a target genomic DNA (e.g., a supporting cell target genomic DNA (e.g., SLC26A4 genomic DNA or a GJB2 genomic DNA) (e.g., any of the exemplary introns in SEQ ID NO: 3 described herein) or a hair cell target genomic DNA (e.g., an OTOF genomic DNA, a TRIOBP genomic DNA, a PJVK genomic DNA, a NDP genomic DNA, a CLRN1 genomic DNA, a TMC1 genomic DNA, a VEGF genomic DNA, a HSPA1A genomic DNA, or a STRC genomic DNA (e.g., any of the exemplary introns in SEQ ID NO: 19, SEQ ID NO: 22, SEQ ID NO: 33, SEQ ID NO: 37, SEQ ID NO: 47, SEQ ID NO: 50, SEQ ID NO: 61, SEQ ID NO: 71 or SEQ ID NO: 80 described herein), and where the two different segments overlap in sequence by at least 100 nucleotides (e.g., about 100 nucleotides to about 3,000 nucleotides, about 100 nucleotides to about 2,500 nucleotides, about 100 nucleotides to about 2,000 nucleotides, about 100 nucleotides to about 1,500 nucleotides, about 100 nucleotides to about 1,000 nucleotides, about 100 nucleotides to about 800 nucleotides, about 100 nucleotides to about 600 nucleotides, about 100 nucleotides to about 400 nucleotides, about 100 nucleotides to about 200 nucleotides, about 200 nucleotides to about 3,000 nucleotides, about 200 nucleotides to about 2,500 nucleotides, about 200 nucleotides to about 2,000 nucleotides, about 200 nucleotides to about 1,500 nucleotides, about 200 nucleotides to about 1,000 nucleotides, about 200 nucleotides to about 800 nucleotides, about 200 nucleotides to about 600 nucleotides, about 200 nucleotides to about 400 nucleotides, about 400 nucleotides to about 3,000 nucleotides, about 400 nucleotides to about 2,500 nucleotides, about 400 nucleotides to about 2,000 nucleotides, about 400 nucleotides to about 1,500 nucleotides, about 400 nucleotides to about 1,000 nucleotides, about 400 nucleotides to about 800 nucleotides, about 400 nucleotides to about 600 nucleotides, about 600 nucleotides to about 3,000 nucleotides, about 600 nucleotides to about 2,500 nucleotides, about 600 nucleotides to about 2,000 nucleotides, about 600 nucleotides to about 1,500 nucleotides, about 600 nucleotides to about 1,000 nucleotides, about 600 nucleotides to about 800 nucleotides, about 800 nucleotides to about 3,000 nucleotides, about 800 nucleotides to about 2,500 nucleotides, about 800 nucleotides to about 2,000 nucleotides, about 800 nucleotides to about 1,500 nucleotides, about 800 nucleotides to about 1,000 nucleotides, about 1,000 nucleotides to about 3,000 nucleotides, about 1,000 nucleotides to about 2,500 nucleotides, about 1,000 nucleotides to about 2,000 nucleotides, about 1,000 nucleotides to about 1,500 nucleotides, about 1,500 nucleotides to about 3,000 nucleotides, about 1,500 nucleotides to about 2,500 nucleotides, about 1,500 nucleotides to about 2,000 nucleotides, about 2,000 nucleotides to about 3,000 nucleotides, about 2,000 nucleotides to about 2,500 nucleotides, or about 2,500 nucleotides to about 3,000 nucleotides), in length.

The overlapping nucleotide sequence in any two of the different vectors can include part or all of one or more exons of a target gene (e.g., a supporting cell target gene (e.g., a SLC26A4 gene or a GJB2 gene) (e.g., any one or more of the exemplary exons in SEQ ID NO: 3 described herein) or a hair cell target gene (e.g., an OTOF gene, a TRIOBP gene, a PJVK gene, a NDP gene, a CLRN1 gene, a TMC1 gene, or a STRC gene) (e.g., any one or more of the exemplary exons in SEQ ID NO: 19, SEQ ID NO: 22, SEQ ID NO: 33, SEQ ID NO: 37, SEQ ID NO: 47, SEQ ID NO: 50, SEQ ID NO: 63, SEQ ID NO: 71 or SEQ ID NO: 80 described herein).

In some embodiments, the number of different vectors in the composition is two, three, four, or five. In compositions where the number of different vectors in the composition is two, the first of the two different vectors can include a coding sequence that encodes an N-terminal portion of the target protein (e.g., an N-terminal portion of the supporting cell target protein or an N-terminal portion of the hair cell target protein). In some examples, the N-terminal portion of the target gene (e.g., the N-terminal portion of the supporting cell target gene or the N-terminal portion of the hair cell target gene) is between about 30 amino acids to about 800 amino acids (e.g., between about 30 amino acids to about 790 amino acids, between about 30 amino acids to about 780 amino acids, between about 30 amino acids to about 770 amino acids, between about 30 amino acids to about 760 amino acids, between about 30 amino acids to about 750 amino acids, between about 30 amino acids to about 740 amino acids, between about 30 amino acids to about 730 amino acids, between about 30 amino acids to about 720 amino acids, between about 30 amino acids to about 710 amino acids, between about 30 amino acids to about 700 amino acids, between about 30 amino acids to about 690 amino acids, between about 30 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 30 amino acids to about 660 amino acids, between about 30 amino acids to about 650 amino acids, between about 30 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 30 amino acids to about 620 amino acids, between about 30 amino acids to about 610 amino acids, between about 30 amino acids to about 600 amino acids, between about 30 amino acids to about 590 amino acids, between about 30 amino acids to about 580 amino acids, between about 30 amino acids to about 570 amino acids, between about 30 amino acids to about 560 amino acids, between about 30 amino acids to about 550 amino acids, between about 30 amino acids to about 540 amino acids, between about 30 amino acids to about 530 amino acids, between about 30 amino acids to about 520 amino acids, between about 30 amino acids to about 510 amino acids, between about 30 amino acids to about 500 amino acids, between about 30 amino acids to about 490 amino acids, between about 30 amino acids to about 480 amino acids, between about 30 amino acids to about 470 amino acids, between about 30 amino acids to about 460 amino acids, between about 30 amino acids to about 450 amino acids, between about 30 amino acids to about 440 amino acids, between about 30 amino acids to about 430 amino acids, between about 30 amino acids to about 420 amino acids, between about 30 amino acids to about 410 amino acids, between about 30 amino acids to about 400 amino acids, between about 30 amino acids to about 390 amino acids, between about 30 amino acids to about 380 amino acids, between about 30 amino acids to about 370 amino acids, between about 30 amino acids to about 360 amino acids, between about 30 amino acids to about 350 amino acids, between about 30 amino acids to about 340 amino acids, between about 30 amino acids to about 330 amino acids, between about 30 amino acids to about 320 amino acids, between about 30 amino acids to about 310 amino acids, between about 30 amino acids to about 300 amino acids, between about 30 amino acids to about 290 amino acids, between about 30 amino acids to about 280 amino acids, between about 30 amino acids to about 270 amino acids, between about 30 amino acids to about 260 amino acids, between about 30 amino acids to about 250 amino acids, between about 30 amino acids to about 240 amino acids, between about 30 amino acids to about 230 amino acids, between about 30 amino acids to about 220 amino acids, between about 30 amino acids to about 210 amino acids, between about 30 amino acids to about 200 amino acids, between about 30 amino acids to about 190 amino acids, between about 30 amino acids to about 180 amino acids, between about 30 amino acids to about 170 amino acids, between about 30 amino acids to about 160 amino acids, between about 30 amino acids to about 150 amino acids, between about 30 amino acids to about 140 amino acids, between about 30 amino acids to about 130 amino acids, between about 30 amino acids to about 120 amino acids, between about 30 amino acids to about 110 amino acids, between about 30 amino acids to about 100 amino acids, between about 30 amino acids to about 90 amino acids, between about 30 amino acids to about 80 amino acids, between about 30 amino acids to about 70 amino acids, between about 30 amino acids to about 60 amino acids, between about 30 amino acids to about 50 amino acids, between about 30 amino acids to about 40 amino acids, between about 50 amino acids to about 800 amino acids, between about 50 amino acids to about 790 amino acids, between about 50 amino acids to about 780 amino acids, between about 50 amino acids to about 770 amino acids, between about 50 amino acids to about 760 amino acids, between about 50 amino acids to about 750 amino acids, between about 50 amino acids to about 740 amino acids, between about 50 amino acids to about 730 amino acids, between about 50 amino acids to about 720 amino acids, between about 50 amino acids to about 710 amino acids, between about 50 amino acids to about 700 amino acids, between about 50 amino acids to about 690 amino acids, between about 50 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 50 amino acids to about 660 amino acids, between about 50 amino acids to about 650 amino acids, between about 50 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 50 amino acids to about 620 amino acids, between about 50 amino acids to about 610 amino acids, between about 50 amino acids to about 600 amino acids, between about 50 amino acids to about 590 amino acids, between about 50 amino acids to about 580 amino acids, between about 50 amino acids to about 570 amino acids, between about 50 amino acids to about 560 amino acids, between about 50 amino acids to about 550 amino acids, between about 50 amino acids to about 540 amino acids, between about 50 amino acids to about 530 amino acids, between about 50 amino acids to about 520 amino acids, between about 50 amino acids to about 510 amino acids, between about 50 amino acids to about 500 amino acids, between about 50 amino acids to about 490 amino acids, between about 50 amino acids to about 480 amino acids, between about 50 amino acids to about 470 amino acids, between about 50 amino acids to about 460 amino acids, between about 50 amino acids to about 450 amino acids, between about 50 amino acids to about 440 amino acids, between about 50 amino acids to about 430 amino acids, between about 50 amino acids to about 420 amino acids, between about 50 amino acids to about 410 amino acids, between about 50 amino acids to about 400 amino acids, between about 50 amino acids to about 390 amino acids, between about 50 amino acids to about 380 amino acids, between about 50 amino acids to about 370 amino acids, between about 50 amino acids to about 360 amino acids, between about 50 amino acids to about 350 amino acids, between about 50 amino acids to about 340 amino acids, between about 50 amino acids to about 330 amino acids, between about 50 amino acids to about 320 amino acids, between about 50 amino acids to about 310 amino acids, between about 50 amino acids to about 300 amino acids, between about 50 amino acids to about 290 amino acids, between about 50 amino acids to about 280 amino acids, between about 50 amino acids to about 270 amino acids, between about 50 amino acids to about 260 amino acids, between about 50 amino acids to about 250 amino acids, between about 50 amino acids to about 240 amino acids, between about 50 amino acids to about 230 amino acids, between about 50 amino acids to about 220 amino acids, between about 50 amino acids to about 210 amino acids, between about 50 amino acids to about 200 amino acids, between about 50 amino acids to about 190 amino acids, between about 50 amino acids to about 180 amino acids, between about 50 amino acids to about 170 amino acids, between about 50 amino acids to about 160 amino acids, between about 50 amino acids to about 150 amino acids, between about 50 amino acids to about 140 amino acids, between about 50 amino acids to about 130 amino acids, between about 50 amino acids to about 120 amino acids, between about 50 amino acids to about 110 amino acids, between about 50 amino acids to about 100 amino acids, between about 50 amino acids to about 90 amino acids, between about 50 amino acids to about 80 amino acids, between about 50 amino acids to about 70 amino acids, between about 50 amino acids to about 60 amino acids, between about 80 amino acids to about 800 amino acids, between about 80 amino acids to about 790 amino acids, between about 80 amino acids to about 780 amino acids, between about 80 amino acids to about 770 amino acids, between about 80 amino acids to about 760 amino acids, between about 80 amino acids to about 750 amino acids, between about 80 amino acids to about 740 amino acids, between about 80 amino acids to about 730 amino acids, between about 80 amino acids to about 720 amino acids, between about 80 amino acids to about 710 amino acids, between about 80 amino acids to about 700 amino acids, between about 80 amino acids to about 690 amino acids, between about 80 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 80 amino acids to about 660 amino acids, between about 80 amino acids to about 650 amino acids, between about 80 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 80 amino acids to about 620 amino acids, between about 80 amino acids to about 610 amino acids, between about 80 amino acids to about 600 amino acids, between about 80 amino acids to about 590 amino acids, between about 80 amino acids to about 580 amino acids, between about 80 amino acids to about 570 amino acids, between about 80 amino acids to about 560 amino acids, between about 80 amino acids to about 550 amino acids, between about 80 amino acids to about 540 amino acids, between about 80 amino acids to about 530 amino acids, between about 80 amino acids to about 520 amino acids, between about 80 amino acids to about 510 amino acids, between about 80 amino acids to about 500 amino acids, between about 80 amino acids to about 490 amino acids, between about 80 amino acids to about 480 amino acids, between about 80 amino acids to about 470 amino acids, between about 80 amino acids to about 460 amino acids, between about 80 amino acids to about 450 amino acids, between about 80 amino acids to about 440 amino acids, between about 80 amino acids to about 430 amino acids, between about 80 amino acids to about 420 amino acids, between about 80 amino acids to about 410 amino acids, between about 80 amino acids to about 400 amino acids, between about 80 amino acids to about 390 amino acids, between about 80 amino acids to about 380 amino acids, between about 80 amino acids to about 370 amino acids, between about 80 amino acids to about 360 amino acids, between about 80 amino acids to about 350 amino acids, between about 80 amino acids to about 340 amino acids, between about 80 amino acids to about 330 amino acids, between about 80 amino acids to about 320 amino acids, between about 80 amino acids to about 310 amino acids, between about 80 amino acids to about 300 amino acids, between about 80 amino acids to about 290 amino acids, between about 80 amino acids to about 280 amino acids, between about 80 amino acids to about 270 amino acids, between about 80 amino acids to about 260 amino acids, between about 80 amino acids to about 250 amino acids, between about 80 amino acids to about 240 amino acids, between about 80 amino acids to about 230 amino acids, between about 80 amino acids to about 220 amino acids, between about 80 amino acids to about 210 amino acids, between about 80 amino acids to about 200 amino acids, between about 80 amino acids to about 190 amino acids, between about 80 amino acids to about 180 amino acids, between about 80 amino acids to about 170 amino acids, between about 80 amino acids to about 160 amino acids, between about 80 amino acids to about 150 amino acids, between about 80 amino acids to about 140 amino acids, between about 80 amino acids to about 130 amino acids, between about 80 amino acids to about 120 amino acids, between about 80 amino acids to about 110 amino acids, between about 80 amino acids to about 100 amino acids, between about 100 amino acids to about 800 amino acids, between about 100 amino acids to about 790 amino acids, between about 100 amino acids to about 780 amino acids, between about 100 amino acids to about 770 amino acids, between about 100 amino acids to about 760 amino acids, between about 100 amino acids to about 750 amino acids, between about 100 amino acids to about 740 amino acids, between about 100 amino acids to about 730 amino acids, between about 100 amino acids to about 720 amino acids, between about 100 amino acids to about 710 amino acids, between about 100 amino acids to about 700 amino acids, between about 100 amino acids to about 690 amino acids, between about 100 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 100 amino acids to about 660 amino acids, between about 100 amino acids to about 650 amino acids, between about 100 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 100 amino acids to about 620 amino acids, between about 100 amino acids to about 610 amino acids, between about 100 amino acids to about 600 amino acids, between about 100 amino acids to about 590 amino acids, between about 100 amino acids to about 580 amino acids, between about 100 amino acids to about 570 amino acids, between about 100 amino acids to about 560 amino acids, between about 100 amino acids to about 550 amino acids, between about 100 amino acids to about 540 amino acids, between about 100 amino acids to about 530 amino acids, between about 100 amino acids to about 520 amino acids, between about 100 amino acids to about 510 amino acids, between about 100 amino acids to about 500 amino acids, between about 100 amino acids to about 490 amino acids, between about 100 amino acids to about 480 amino acids, between about 100 amino acids to about 470 amino acids, between about 100 amino acids to about 460 amino acids, between about 100 amino acids to about 450 amino acids, between about 100 amino acids to about 440 amino acids, between about 100 amino acids to about 430 amino acids, between about 100 amino acids to about 420 amino acids, between about 100 amino acids to about 410 amino acids, between about 100 amino acids to about 400 amino acids, between about 100 amino acids to about 390 amino acids, between about 100 amino acids to about 380 amino acids, between about 100 amino acids to about 370 amino acids, between about 100 amino acids to about 360 amino acids, between about 100 amino acids to about 350 amino acids, between about 100 amino acids to about 340 amino acids, between about 100 amino acids to about 330 amino acids, between about 100 amino acids to about 320 amino acids, between about 100 amino acids to about 310 amino acids, between about 100 amino acids to about 300 amino acids, between about 100 amino acids to about 290 amino acids, between about 100 amino acids to about 280 amino acids, between about 100 amino acids to about 270 amino acids, between about 100 amino acids to about 260 amino acids, between about 100 amino acids to about 250 amino acids, between about 100 amino acids to about 240 amino acids, between about 100 amino acids to about 230 amino acids, between about 100 amino acids to about 220 amino acids, between about 100 amino acids to about 210 amino acids, between about 100 amino acids to about 200 amino acids, between about 100 amino acids to about 190 amino acids, between about 100 amino acids to about 180 amino acids, between about 100 amino acids to about 170 amino acids, between about 100 amino acids to about 160 amino acids, between about 100 amino acids to about 150 amino acids, between about 100 amino acids to about 140 amino acids, between about 100 amino acids to about 130 amino acids, between about 100 amino acids to about 120 amino acids, between about 100 amino acids to about 110 amino acids, between about 120 amino acids to about 800 amino acids, between about 120 amino acids to about 790 amino acids, between about 120 amino acids to about 780 amino acids, between about 120 amino acids to about 770 amino acids, between about 120 amino acids to about 760 amino acids, between about 120 amino acids to about 750 amino acids, between about 120 amino acids to about 740 amino acids, between about 120 amino acids to about 730 amino acids, between about 120 amino acids to about 720 amino acids, between about 120 amino acids to about 710 amino acids, between about 120 amino acids to about 700 amino acids, between about 120 amino acids to about 690 amino acids, between about 120 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 120 amino acids to about 660 amino acids, between about 120 amino acids to about 650 amino acids, between about 120 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 120 amino acids to about 620 amino acids, between about 120 amino acids to about 610 amino acids, between about 120 amino acids to about 600 amino acids, between about 120 amino acids to about 590 amino acids, between about 120 amino acids to about 580 amino acids, between about 120 amino acids to about 570 amino acids, between about 120 amino acids to about 560 amino acids, between about 120 amino acids to about 550 amino acids, between about 120 amino acids to about 540 amino acids, between about 120 amino acids to about 530 amino acids, between about 120 amino acids to about 520 amino acids, between about 120 amino acids to about 510 amino acids, between about 120 amino acids to about 500 amino acids, between about 120 amino acids to about 490 amino acids, between about 120 amino acids to about 480 amino acids, between about 120 amino acids to about 470 amino acids, between about 120 amino acids to about 460 amino acids, between about 120 amino acids to about 450 amino acids, between about 120 amino acids to about 440 amino acids, between about 120 amino acids to about 430 amino acids, between about 120 amino acids to about 420 amino acids, between about 120 amino acids to about 410 amino acids, between about 120 amino acids to about 400 amino acids, between about 120 amino acids to about 390 amino acids, between about 120 amino acids to about 380 amino acids, between about 120 amino acids to about 370 amino acids, between about 120 amino acids to about 360 amino acids, between about 120 amino acids to about 350 amino acids, between about 120 amino acids to about 340 amino acids, between about 120 amino acids to about 330 amino acids, between about 120 amino acids to about 320 amino acids, between about 120 amino acids to about 310 amino acids, between about 120 amino acids to about 300 amino acids, between about 120 amino acids to about 290 amino acids, between about 120 amino acids to about 280 amino acids, between about 120 amino acids to about 270 amino acids, between about 120 amino acids to about 260 amino acids, between about 120 amino acids to about 250 amino acids, between about 120 amino acids to about 240 amino acids, between about 120 amino acids to about 230 amino acids, between about 120 amino acids to about 220 amino acids, between about 120 amino acids to about 210 amino acids, between about 120 amino acids to about 200 amino acids, between about 120 amino acids to about 190 amino acids, between about 120 amino acids to about 180 amino acids, between about 120 amino acids to about 170 amino acids, between about 120 amino acids to about 160 amino acids, between about 120 amino acids to about 150 amino acids, between about 120 amino acids to about 140 amino acids, between about 120 amino acids to about 130 amino acids, between about 150 amino acids to about 800 amino acids, between about 150 amino acids to about 790 amino acids, between about 150 amino acids to about 780 amino acids, between about 150 amino acids to about 770 amino acids, between about 150 amino acids to about 760 amino acids, between about 150 amino acids to about 750 amino acids, between about 150 amino acids to about 740 amino acids, between about 150 amino acids to about 730 amino acids, between about 150 amino acids to about 720 amino acids, between about 150 amino acids to about 710 amino acids, between about 150 amino acids to about 700 amino acids, between about 150 amino acids to about 690 amino acids, between about 150 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 150 amino acids to about 660 amino acids, between about 150 amino acids to about 650 amino acids, between about 150 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 150 amino acids to about 620 amino acids, between about 150 amino acids to about 610 amino acids, between about 150 amino acids to about 600 amino acids, between about 150 amino acids to about 590 amino acids, between about 150 amino acids to about 580 amino acids, between about 150 amino acids to about 570 amino acids, between about 150 amino acids to about 560 amino acids, between about 150 amino acids to about 550 amino acids, between about 150 amino acids to about 540 amino acids, between about 150 amino acids to about 530 amino acids, between about 150 amino acids to about 520 amino acids, between about 150 amino acids to about 510 amino acids, between about 150 amino acids to about 500 amino acids, between about 150 amino acids to about 490 amino acids, between about 150 amino acids to about 480 amino acids, between about 150 amino acids to about 470 amino acids, between about 150 amino acids to about 460 amino acids, between about 150 amino acids to about 450 amino acids, between about 150 amino acids to about 440 amino acids, between about 150 amino acids to about 430 amino acids, between about 150 amino acids to about 420 amino acids, between about 150 amino acids to about 410 amino acids, between about 150 amino acids to about 400 amino acids, between about 150 amino acids to about 390 amino acids, between about 150 amino acids to about 380 amino acids, between about 150 amino acids to about 370 amino acids, between about 150 amino acids to about 360 amino acids, between about 150 amino acids to about 350 amino acids, between about 150 amino acids to about 340 amino acids, between about 150 amino acids to about 330 amino acids, between about 150 amino acids to about 320 amino acids, between about 150 amino acids to about 310 amino acids, between about 150 amino acids to about 300 amino acids, between about 150 amino acids to about 290 amino acids, between about 150 amino acids to about 280 amino acids, between about 150 amino acids to about 270 amino acids, between about 150 amino acids to about 260 amino acids, between about 150 amino acids to about 250 amino acids, between about 150 amino acids to about 240 amino acids, between about 150 amino acids to about 230 amino acids, between about 150 amino acids to about 220 amino acids, between about 150 amino acids to about 210 amino acids, between about 150 amino acids to about 200 amino acids, between about 150 amino acids to about 190 amino acids, between about 150 amino acids to about 180 amino acids, between about 150 amino acids to about 170 amino acids, between about 150 amino acids to about 160 amino acids, between about 180 amino acids to about 800 amino acids, between about 180 amino acids to about 790 amino acids, between about 180 amino acids to about 780 amino acids, between about 180 amino acids to about 770 amino acids, between about 180 amino acids to about 760 amino acids, between about 180 amino acids to about 750 amino acids, between about 180 amino acids to about 740 amino acids, between about 180 amino acids to about 730 amino acids, between about 180 amino acids to about 720 amino acids, between about 180 amino acids to about 710 amino acids, between about 180 amino acids to about 700 amino acids, between about 180 amino acids to about 690 amino acids, between about 180 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 180 amino acids to about 660 amino acids, between about 180 amino acids to about 650 amino acids, between about 180 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 180 amino acids to about 620 amino acids, between about 180 amino acids to about 610 amino acids, between about 180 amino acids to about 600 amino acids, between about 180 amino acids to about 590 amino acids, between about 180 amino acids to about 580 amino acids, between about 180 amino acids to about 570 amino acids, between about 180 amino acids to about 560 amino acids, between about 180 amino acids to about 550 amino acids, between about 180 amino acids to about 540 amino acids, between about 180 amino acids to about 530 amino acids, between about 180 amino acids to about 520 amino acids, between about 180 amino acids to about 510 amino acids, between about 180 amino acids to about 500 amino acids, between about 180 amino acids to about 490 amino acids, between about 180 amino acids to about 480 amino acids, between about 180 amino acids to about 470 amino acids, between about 180 amino acids to about 460 amino acids, between about 180 amino acids to about 450 amino acids, between about 180 amino acids to about 440 amino acids, between about 180 amino acids to about 430 amino acids, between about 180 amino acids to about 420 amino acids, between about 180 amino acids to about 410 amino acids, between about 180 amino acids to about 400 amino acids, between about 180 amino acids to about 390 amino acids, between about 180 amino acids to about 380 amino acids, between about 180 amino acids to about 370 amino acids, between about 180 amino acids to about 360 amino acids, between about 180 amino acids to about 350 amino acids, between about 180 amino acids to about 340 amino acids, between about 180 amino acids to about 330 amino acids, between about 180 amino acids to about 320 amino acids, between about 180 amino acids to about 310 amino acids, between about 180 amino acids to about 300 amino acids, between about 180 amino acids to about 290 amino acids, between about 180 amino acids to about 280 amino acids, between about 180 amino acids to about 270 amino acids, between about 180 amino acids to about 260 amino acids, between about 180 amino acids to about 250 amino acids, between about 180 amino acids to about 240 amino acids, between about 180 amino acids to about 230 amino acids, between about 180 amino acids to about 220 amino acids, between about 180 amino acids to about 210 amino acids, between about 180 amino acids to about 200 amino acids, between about 180 amino acids to about 190 amino acids, between about 200 amino acids to about 800 amino acids, between about 200 amino acids to about 790 amino acids, between about 200 amino acids to about 780 amino acids, between about 200 amino acids to about 770 amino acids, between about 200 amino acids to about 760 amino acids, between about 200 amino acids to about 750 amino acids, between about 200 amino acids to about 740 amino acids, between about 200 amino acids to about 730 amino acids, between about 200 amino acids to about 720 amino acids, between about 200 amino acids to about 710 amino acids, between about 200 amino acids to about 700 amino acids, between about 200 amino acids to about 690 amino acids, between about 200 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 200 amino acids to about 660 amino acids, between about 200 amino acids to about 650 amino acids, between about 200 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 200 amino acids to about 620 amino acids, between about 200 amino acids to about 610 amino acids, between about 200 amino acids to about 600 amino acids, between about 200 amino acids to about 590 amino acids, between about 200 amino acids to about 580 amino acids, between about 200 amino acids to about 570 amino acids, between about 200 amino acids to about 560 amino acids, between about 200 amino acids to about 550 amino acids, between about 200 amino acids to about 540 amino acids, between about 200 amino acids to about 530 amino acids, between about 200 amino acids to about 520 amino acids, between about 200 amino acids to about 510 amino acids, between about 200 amino acids to about 500 amino acids, between about 200 amino acids to about 490 amino acids, between about 200 amino acids to about 480 amino acids, between about 200 amino acids to about 470 amino acids, between about 200 amino acids to about 460 amino acids, between about 200 amino acids to about 450 amino acids, between about 200 amino acids to about 440 amino acids, between about 200 amino acids to about 430 amino acids, between about 200 amino acids to about 420 amino acids, between about 200 amino acids to about 410 amino acids, between about 200 amino acids to about 400 amino acids, between about 200 amino acids to about 390 amino acids, between about 200 amino acids to about 380 amino acids, between about 200 amino acids to about 370 amino acids, between about 200 amino acids to about 360 amino acids, between about 200 amino acids to about 350 amino acids, between about 200 amino acids to about 340 amino acids, between about 200 amino acids to about 330 amino acids, between about 200 amino acids to about 320 amino acids, between about 200 amino acids to about 310 amino acids, between about 200 amino acids to about 300 amino acids, between about 200 amino acids to about 290 amino acids, between about 200 amino acids to about 280 amino acids, between about 200 amino acids to about 270 amino acids, between about 200 amino acids to about 260 amino acids, between about 200 amino acids to about 250 amino acids, between about 200 amino acids to about 240 amino acids, between about 200 amino acids to about 230 amino acids, between about 200 amino acids to about 220 amino acids, between about 200 amino acids to about 210 amino acids, between about 250 amino acids to about 800 amino acids, between about 250 amino acids to about 790 amino acids, between about 250 amino acids to about 780 amino acids, between about 250 amino acids to about 770 amino acids, between about 250 amino acids to about 760 amino acids, between about 250 amino acids to about 750 amino acids, between about 250 amino acids to about 740 amino acids, between about 250 amino acids to about 730 amino acids, between about 250 amino acids to about 720 amino acids, between about 250 amino acids to about 710 amino acids, between about 250 amino acids to about 700 amino acids, between about 250 amino acids to about 690 amino acids, between about 250 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 250 amino acids to about 660 amino acids, between about 250 amino acids to about 650 amino acids, between about 250 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 250 amino acids to about 620 amino acids, between about 250 amino acids to about 610 amino acids, between about 250 amino acids to about 600 amino acids, between about 250 amino acids to about 590 amino acids, between about 250 amino acids to about 580 amino acids, between about 250 amino acids to about 570 amino acids, between about 250 amino acids to about 560 amino acids, between about 250 amino acids to about 550 amino acids, between about 250 amino acids to about 540 amino acids, between about 250 amino acids to about 530 amino acids, between about 250 amino acids to about 520 amino acids, between about 250 amino acids to about 510 amino acids, between about 250 amino acids to about 500 amino acids, between about 250 amino acids to about 490 amino acids, between about 250 amino acids to about 480 amino acids, between about 250 amino acids to about 470 amino acids, between about 250 amino acids to about 460 amino acids, between about 250 amino acids to about 450 amino acids, between about 250 amino acids to about 440 amino acids, between about 250 amino acids to about 430 amino acids, between about 250 amino acids to about 420 amino acids, between about 250 amino acids to about 410 amino acids, between about 250 amino acids to about 400 amino acids, between about 250 amino acids to about 390 amino acids, between about 250 amino acids to about 380 amino acids, between about 250 amino acids to about 370 amino acids, between about 250 amino acids to about 360 amino acids, between about 250 amino acids to about 350 amino acids, between about 250 amino acids to about 340 amino acids, between about 250 amino acids to about 330 amino acids, between about 250 amino acids to about 320 amino acids, between about 250 amino acids to about 310 amino acids, between about 250 amino acids to about 300 amino acids, between about 250 amino acids to about 290 amino acids, between about 250 amino acids to about 280 amino acids, between about 250 amino acids to about 270 amino acids, between about 250 amino acids to about 260 amino acids, between about 280 amino acids to about 800 amino acids, between about 280 amino acids to about 790 amino acids, between about 280 amino acids to about 780 amino acids, between about 280 amino acids to about 770 amino acids, between about 280 amino acids to about 760 amino acids, between about 280 amino acids to about 750 amino acids, between about 280 amino acids to about 740 amino acids, between about 280 amino acids to about 730 amino acids, between about 280 amino acids to about 720 amino acids, between about 280 amino acids to about 710 amino acids, between about 280 amino acids to about 700 amino acids, between about 280 amino acids to about 690 amino acids, between about 280 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 280 amino acids to about 660 amino acids, between about 280 amino acids to about 650 amino acids, between about 280 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 280 amino acids to about 620 amino acids, between about 280 amino acids to about 610 amino acids, between about 280 amino acids to about 600 amino acids, between about 280 amino acids to about 590 amino acids, between about 280 amino acids to about 580 amino acids, between about 280 amino acids to about 570 amino acids, between about 280 amino acids to about 560 amino acids, between about 280 amino acids to about 550 amino acids, between about 280 amino acids to about 540 amino acids, between about 280 amino acids to about 530 amino acids, between about 280 amino acids to about 520 amino acids, between about 280 amino acids to about 510 amino acids, between about 280 amino acids to about 500 amino acids, between about 280 amino acids to about 490 amino acids, between about 280 amino acids to about 480 amino acids, between about 280 amino acids to about 470 amino acids, between about 280 amino acids to about 460 amino acids, between about 280 amino acids to about 450 amino acids, between about 280 amino acids to about 440 amino acids, between about 280 amino acids to about 430 amino acids, between about 280 amino acids to about 420 amino acids, between about 280 amino acids to about 410 amino acids, between about 280 amino acids to about 400 amino acids, between about 280 amino acids to about 390 amino acids, between about 280 amino acids to about 380 amino acids, between about 280 amino acids to about 370 amino acids, between about 280 amino acids to about 360 amino acids, between about 280 amino acids to about 350 amino acids, between about 280 amino acids to about 340 amino acids, between about 280 amino acids to about 330 amino acids, between about 280 amino acids to about 320 amino acids, between about 280 amino acids to about 310 amino acids, between about 280 amino acids to about 300 amino acids, between about 300 amino acids to about 800 amino acids, between about 300 amino acids to about 790 amino acids, between about 300 amino acids to about 780 amino acids, between about 300 amino acids to about 770 amino acids, between about 300 amino acids to about 760 amino acids, between about 300 amino acids to about 750 amino acids, between about 300 amino acids to about 740 amino acids, between about 300 amino acids to about 730 amino acids, between about 300 amino acids to about 720 amino acids, between about 300 amino acids to about 710 amino acids, between about 300 amino acids to about 700 amino acids, between about 300 amino acids to about 690 amino acids, between about 300 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 300 amino acids to about 660 amino acids, between about 300 amino acids to about 650 amino acids, between about 300 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 300 amino acids to about 620 amino acids, between about 300 amino acids to about 610 amino acids, between about 300 amino acids to about 600 amino acids, between about 300 amino acids to about 590 amino acids, between about 300 amino acids to about 580 amino acids, between about 300 amino acids to about 570 amino acids, between about 300 amino acids to about 560 amino acids, between about 300 amino acids to about 550 amino acids, between about 300 amino acids to about 540 amino acids, between about 300 amino acids to about 530 amino acids, between about 300 amino acids to about 520 amino acids, between about 300 amino acids to about 510 amino acids, between about 300 amino acids to about 500 amino acids, between about 300 amino acids to about 490 amino acids, between about 300 amino acids to about 480 amino acids, between about 300 amino acids to about 470 amino acids, between about 300 amino acids to about 460 amino acids, between about 300 amino acids to about 450 amino acids, between about 300 amino acids to about 440 amino acids, between about 300 amino acids to about 430 amino acids, between about 300 amino acids to about 420 amino acids, between about 300 amino acids to about 410 amino acids, between about 300 amino acids to about 400 amino acids, between about 300 amino acids to about 390 amino acids, between about 300 amino acids to about 380 amino acids, between about 300 amino acids to about 370 amino acids, between about 300 amino acids to about 360 amino acids, between about 300 amino acids to about 350 amino acids, between about 300 amino acids to about 340 amino acids, between about 300 amino acids to about 330 amino acids, between about 300 amino acids to about 320 amino acids, between about 300 amino acids to about 310 amino acids, between about 350 amino acids to about 800 amino acids, between about 350 amino acids to about 790 amino acids, between about 350 amino acids to about 780 amino acids, between about 350 amino acids to about 770 amino acids, between about 350 amino acids to about 760 amino acids, between about 350 amino acids to about 750 amino acids, between about 350 amino acids to about 740 amino acids, between about 350 amino acids to about 730 amino acids, between about 350 amino acids to about 720 amino acids, between about 350 amino acids to about 710 amino acids, between about 350 amino acids to about 700 amino acids, between about 350 amino acids to about 690 amino acids, between about 350 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 350 amino acids to about 660 amino acids, between about 350 amino acids to about 650 amino acids, between about 350 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 350 amino acids to about 620 amino acids, between about 350 amino acids to about 610 amino acids, between about 350 amino acids to about 600 amino acids, between about 350 amino acids to about 590 amino acids, between about 350 amino acids to about 580 amino acids, between about 350 amino acids to about 570 amino acids, between about 350 amino acids to about 560 amino acids, between about 350 amino acids to about 550 amino acids, between about 350 amino acids to about 540 amino acids, between about 350 amino acids to about 530 amino acids, between about 350 amino acids to about 520 amino acids, between about 350 amino acids to about 510 amino acids, between about 350 amino acids to about 500 amino acids, between about 350 amino acids to about 490 amino acids, between about 350 amino acids to about 480 amino acids, between about 350 amino acids to about 470 amino acids, between about 350 amino acids to about 460 amino acids, between about 350 amino acids to about 450 amino acids, between about 350 amino acids to about 440 amino acids, between about 350 amino acids to about 430 amino acids, between about 350 amino acids to about 420 amino acids, between about 350 amino acids to about 410 amino acids, between about 350 amino acids to about 400 amino acids, between about 350 amino acids to about 390 amino acids, between about 350 amino acids to about 380 amino acids, between about 350 amino acids to about 370 amino acids, between about 350 amino acids to about 360 amino acids, between about 380 amino acids to about 800 amino acids, between about 380 amino acids to about 790 amino acids, between about 380 amino acids to about 780 amino acids, between about 380 amino acids to about 770 amino acids, between about 380 amino acids to about 760 amino acids, between about 380 amino acids to about 750 amino acids, between about 380 amino acids to about 740 amino acids, between about 380 amino acids to about 730 amino acids, between about 380 amino acids to about 720 amino acids, between about 380 amino acids to about 710 amino acids, between about 380 amino acids to about 700 amino acids, between about 380 amino acids to about 690 amino acids, between about 380 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 380 amino acids to about 660 amino acids, between about 380 amino acids to about 650 amino acids, between about 380 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 380 amino acids to about 620 amino acids, between about 380 amino acids to about 610 amino acids, between about 380 amino acids to about 600 amino acids, between about 380 amino acids to about 590 amino acids, between about 380 amino acids to about 580 amino acids, between about 380 amino acids to about 570 amino acids, between about 380 amino acids to about 560 amino acids, between about 380 amino acids to about 550 amino acids, between about 380 amino acids to about 540 amino acids, between about 380 amino acids to about 530 amino acids, between about 380 amino acids to about 520 amino acids, between about 380 amino acids to about 510 amino acids, between about 380 amino acids to about 500 amino acids, between about 380 amino acids to about 490 amino acids, between about 380 amino acids to about 480 amino acids, between about 380 amino acids to about 470 amino acids, between about 380 amino acids to about 460 amino acids, between about 380 amino acids to about 450 amino acids, between about 380 amino acids to about 440 amino acids, between about 380 amino acids to about 430 amino acids, between about 380 amino acids to about 420 amino acids, between about 380 amino acids to about 410 amino acids, between about 380 amino acids to about 400 amino acids, between about 380 amino acids to about 390 amino acids, between about 400 amino acids to about 800 amino acids, between about 400 amino acids to about 790 amino acids, between about 400 amino acids to about 780 amino acids, between about 400 amino acids to about 770 amino acids, between about 400 amino acids to about 760 amino acids, between about 400 amino acids to about 750 amino acids, between about 400 amino acids to about 740 amino acids, between about 400 amino acids to about 730 amino acids, between about 400 amino acids to about 720 amino acids, between about 400 amino acids to about 710 amino acids, between about 400 amino acids to about 700 amino acids, between about 400 amino acids to about 690 amino acids, between about 400 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 400 amino acids to about 660 amino acids, between about 400 amino acids to about 650 amino acids, between about 400 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 400 amino acids to about 620 amino acids, between about 400 amino acids to about 610 amino acids, between about 400 amino acids to about 600 amino acids, between about 400 amino acids to about 590 amino acids, between about 400 amino acids to about 580 amino acids, between about 400 amino acids to about 570 amino acids, between about 400 amino acids to about 560 amino acids, between about 400 amino acids to about 550 amino acids, between about 400 amino acids to about 540 amino acids, between about 400 amino acids to about 530 amino acids, between about 400 amino acids to about 520 amino acids, between about 400 amino acids to about 510 amino acids, between about 400 amino acids to about 500 amino acids, between about 400 amino acids to about 490 amino acids, between about 400 amino acids to about 480 amino acids, between about 400 amino acids to about 470 amino acids, between about 400 amino acids to about 460 amino acids, between about 400 amino acids to about 450 amino acids, between about 400 amino acids to about 440 amino acids, between about 400 amino acids to about 430 amino acids, between about 400 amino acids to about 420 amino acids, between about 400 amino acids to about 410 amino acids, between about 450 amino acids to about 800 amino acids, between about 450 amino acids to about 790 amino acids, between about 450 amino acids to about 780 amino acids, between about 450 amino acids to about 770 amino acids, between about 450 amino acids to about 760 amino acids, between about 450 amino acids to about 750 amino acids, between about 450 amino acids to about 740 amino acids, between about 450 amino acids to about 730 amino acids, between about 450 amino acids to about 720 amino acids, between about 450 amino acids to about 710 amino acids, between about 450 amino acids to about 700 amino acids, between about 450 amino acids to about 690 amino acids, between about 450 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 450 amino acids to about 660 amino acids, between about 450 amino acids to about 650 amino acids, between about 450 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 450 amino acids to about 620 amino acids, between about 450 amino acids to about 610 amino acids, between about 450 amino acids to about 600 amino acids, between about 450 amino acids to about 590 amino acids, between about 450 amino acids to about 580 amino acids, between about 450 amino acids to about 570 amino acids, between about 450 amino acids to about 560 amino acids, between about 450 amino acids to about 550 amino acids, between about 450 amino acids to about 540 amino acids, between about 450 amino acids to about 530 amino acids, between about 450 amino acids to about 520 amino acids, between about 450 amino acids to about 510 amino acids, between about 450 amino acids to about 500 amino acids, between about 450 amino acids to about 490 amino acids, between about 450 amino acids to about 480 amino acids, between about 450 amino acids to about 470 amino acids, between about 450 amino acids to about 460 amino acids, between about 480 amino acids to about 800 amino acids, between about 480 amino acids to about 790 amino acids, between about 480 amino acids to about 780 amino acids, between about 480 amino acids to about 770 amino acids, between about 480 amino acids to about 760 amino acids, between about 480 amino acids to about 750 amino acids, between about 480 amino acids to about 740 amino acids, between about 480 amino acids to about 730 amino acids, between about 480 amino acids to about 720 amino acids, between about 480 amino acids to about 710 amino acids, between about 480 amino acids to about 700 amino acids, between about 480 amino acids to about 690 amino acids, between about 480 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 480 amino acids to about 660 amino acids, between about 480 amino acids to about 650 amino acids, between about 480 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 480 amino acids to about 620 amino acids, between about 480 amino acids to about 610 amino acids, between about 480 amino acids to about 600 amino acids, between about 480 amino acids to about 590 amino acids, between about 480 amino acids to about 580 amino acids, between about 480 amino acids to about 570 amino acids, between about 480 amino acids to about 560 amino acids, between about 480 amino acids to about 550 amino acids, between about 480 amino acids to about 540 amino acids, between about 480 amino acids to about 530 amino acids, between about 480 amino acids to about 520 amino acids, between about 480 amino acids to about 510 amino acids, between about 480 amino acids to about 500 amino acids, between about 480 amino acids to about 490 amino acids, between about 50 amino acids to about 800 amino acids, between about 50 amino acids to about 790 amino acids, between about 50 amino acids to about 780 amino acids, between about 50 amino acids to about 770 amino acids, between about 50 amino acids to about 760 amino acids, between about 50 amino acids to about 750 amino acids, between about 50 amino acids to about 740 amino acids, between about 50 amino acids to about 730 amino acids, between about 50 amino acids to about 720 amino acids, between about 50 amino acids to about 710 amino acids, between about 50 amino acids to about 700 amino acids, between about 50 amino acids to about 690 amino acids, between about 50 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 50 amino acids to about 660 amino acids, between about 50 amino acids to about 650 amino acids, between about 50 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 50 amino acids to about 620 amino acids, between about 50 amino acids to about 610 amino acids, between about 50 amino acids to about 600 amino acids, between about 50 amino acids to about 590 amino acids, between about 50 amino acids to about 580 amino acids, between about 50 amino acids to about 570 amino acids, between about 50 amino acids to about 560 amino acids, between about 50 amino acids to about 550 amino acids, between about 50 amino acids to about 540 amino acids, between about 50 amino acids to about 530 amino acids, between about 50 amino acids to about 520 amino acids, between about 50 amino acids to about 510 amino acids, between about 550 amino acids to about 800 amino acids, between about 550 amino acids to about 790 amino acids, between about 550 amino acids to about 780 amino acids, between about 550 amino acids to about 770 amino acids, between about 550 amino acids to about 760 amino acids, between about 550 amino acids to about 750 amino acids, between about 550 amino acids to about 740 amino acids, between about 550 amino acids to about 730 amino acids, between about 550 amino acids to about 720 amino acids, between about 550 amino acids to about 710 amino acids, between about 550 amino acids to about 700 amino acids, between about 550 amino acids to about 690 amino acids, between about 550 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 550 amino acids to about 660 amino acids, between about 550 amino acids to about 650 amino acids, between about 550 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 550 amino acids to about 620 amino acids, between about 550 amino acids to about 610 amino acids, between about 550 amino acids to about 600 amino acids, between about 550 amino acids to about 590 amino acids, between about 550 amino acids to about 580 amino acids, between about 550 amino acids to about 570 amino acids, between about 550 amino acids to about 560 amino acids, between about 580 amino acids to about 800 amino acids, between about 580 amino acids to about 790 amino acids, between about 580 amino acids to about 780 amino acids, between about 580 amino acids to about 770 amino acids, between about 580 amino acids to about 760 amino acids, between about 580 amino acids to about 750 amino acids, between about 580 amino acids to about 740 amino acids, between about 580 amino acids to about 730 amino acids, between about 580 amino acids to about 720 amino acids, between about 580 amino acids to about 710 amino acids, between about 580 amino acids to about 700 amino acids, between about 580 amino acids to about 690 amino acids, between about 580 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 580 amino acids to about 660 amino acids, between about 580 amino acids to about 650 amino acids, between about 580 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 580 amino acids to about 620 amino acids, between about 580 amino acids to about 610 amino acids, between about 580 amino acids to about 600 amino acids, between about 580 amino acids to about 590 amino acids, between about 600 amino acids to about 800 amino acids, between about 600 amino acids to about 790 amino acids, between about 600 amino acids to about 780 amino acids, between about 600 amino acids to about 770 amino acids, between about 600 amino acids to about 760 amino acids, between about 600 amino acids to about 750 amino acids, between about 600 amino acids to about 740 amino acids, between about 600 amino acids to about 730 amino acids, between about 600 amino acids to about 720 amino acids, between about 600 amino acids to about 710 amino acids, between about 600 amino acids to about 700 amino acids, between about 600 amino acids to about 690 amino acids, between about 600 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 600 amino acids to about 660 amino acids, between about 600 amino acids to about 650 amino acids, between about 600 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 600 amino acids to about 620 amino acids, between about 600 amino acids to about 610 amino acids, between about 650 amino acids to about 800 amino acids, between about 650 amino acids to about 790 amino acids, between about 650 amino acids to about 780 amino acids, between about 650 amino acids to about 770 amino acids, between about 650 amino acids to about 760 amino acids, between about 650 amino acids to about 750 amino acids, between about 650 amino acids to about 740 amino acids, between about 650 amino acids to about 730 amino acids, between about 650 amino acids to about 720 amino acids, between about 650 amino acids to about 710 amino acids, between about 650 amino acids to about 700 amino acids, between about 650 amino acids to about 690 amino acids, between about 650 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 650 amino acids to about 660 amino acids, between about 680 amino acids to about 800 amino acids, between about 680 amino acids to about 790 amino acids, between about 680 amino acids to about 780 amino acids, between about 680 amino acids to about 770 amino acids, between about 680 amino acids to about 760 amino acids, between about 680 amino acids to about 750 amino acids, between about 680 amino acids to about 740 amino acids, between about 680 amino acids to about 730 amino acids, between about 680 amino acids to about 720 amino acids, between about 680 amino acids to about 710 amino acids, between about 680 amino acids to about 700 amino acids, between about 680 amino acids to about 690 amino acids, between about 700 amino acids to about 800 amino acids, between about 700 amino acids to about 790 amino acids, between about 700 amino acids to about 780 amino acids, between about 700 amino acids to about 770 amino acids, between about 700 amino acids to about 760 amino acids, between about 700 amino acids to about 750 amino acids, between about 700 amino acids to about 740 amino acids, between about 700 amino acids to about 730 amino acids, between about 700 amino acids to about 720 amino acids, between about 700 amino acids to about 710 amino acids, between about 750 amino acids to about 800 amino acids, between about 750 amino acids to about 790 amino acids, between about 750 amino acids to about 780 amino acids, between about 750 amino acids to about 770 amino acids, between about 750 amino acids to about 760 amino acids, or between about 780 amino acids to about 800 amino acids) in length. In some examples, the first vector further includes one or both of a promoter (e.g., any of the promoters described herein or known in the art) and a Kozak sequence (e.g., any of the exemplary Kozak sequences described herein or known in the art). In some examples, the first vector includes a promoter that is an inducible promoter, a constitutive promoter, or a tissue-specific promoter. In some examples, the second of the two different vectors includes a coding sequence that encodes a C-terminal portion of the target protein (e.g., a C-terminal potion of the supporting cell target protein or a C-terminal portion of the hair cell target protein). In some examples, the C-terminal portion of the target protein (e.g., the C-terminal portion of the supporting cell target protein or the C-terminal portion of the hair cell target protein) is between about 30 amino acids to about 800 amino acids (e.g., between about 30 amino acids to about 790 amino acids, between about 30 amino acids to about 780 amino acids, between about 30 amino acids to about 770 amino acids, between about 30 amino acids to about 760 amino acids, between about 30 amino acids to about 750 amino acids, between about 30 amino acids to about 740 amino acids, between about 30 amino acids to about 730 amino acids, between about 30 amino acids to about 720 amino acids, between about 30 amino acids to about 710 amino acids, between about 30 amino acids to about 700 amino acids, between about 30 amino acids to about 690 amino acids, between about 30 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 30 amino acids to about 660 amino acids, between about 30 amino acids to about 650 amino acids, between about 30 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 30 amino acids to about 620 amino acids, between about 30 amino acids to about 610 amino acids, between about 30 amino acids to about 600 amino acids, between about 30 amino acids to about 590 amino acids, between about 30 amino acids to about 580 amino acids, between about 30 amino acids to about 570 amino acids, between about 30 amino acids to about 560 amino acids, between about 30 amino acids to about 550 amino acids, between about 30 amino acids to about 540 amino acids, between about 30 amino acids to about 530 amino acids, between about 30 amino acids to about 520 amino acids, between about 30 amino acids to about 510 amino acids, between about 30 amino acids to about 500 amino acids, between about 30 amino acids to about 490 amino acids, between about 30 amino acids to about 480 amino acids, between about 30 amino acids to about 470 amino acids, between about 30 amino acids to about 460 amino acids, between about 30 amino acids to about 450 amino acids, between about 30 amino acids to about 440 amino acids, between about 30 amino acids to about 430 amino acids, between about 30 amino acids to about 420 amino acids, between about 30 amino acids to about 410 amino acids, between about 30 amino acids to about 400 amino acids, between about 30 amino acids to about 390 amino acids, between about 30 amino acids to about 380 amino acids, between about 30 amino acids to about 370 amino acids, between about 30 amino acids to about 360 amino acids, between about 30 amino acids to about 350 amino acids, between about 30 amino acids to about 340 amino acids, between about 30 amino acids to about 330 amino acids, between about 30 amino acids to about 320 amino acids, between about 30 amino acids to about 310 amino acids, between about 30 amino acids to about 300 amino acids, between about 30 amino acids to about 290 amino acids, between about 30 amino acids to about 280 amino acids, between about 30 amino acids to about 270 amino acids, between about 30 amino acids to about 260 amino acids, between about 30 amino acids to about 250 amino acids, between about 30 amino acids to about 240 amino acids, between about 30 amino acids to about 230 amino acids, between about 30 amino acids to about 220 amino acids, between about 30 amino acids to about 210 amino acids, between about 30 amino acids to about 200 amino acids, between about 30 amino acids to about 190 amino acids, between about 30 amino acids to about 180 amino acids, between about 30 amino acids to about 170 amino acids, between about 30 amino acids to about 160 amino acids, between about 30 amino acids to about 150 amino acids, between about 30 amino acids to about 140 amino acids, between about 30 amino acids to about 130 amino acids, between about 30 amino acids to about 120 amino acids, between about 30 amino acids to about 110 amino acids, between about 30 amino acids to about 100 amino acids, between about 30 amino acids to about 90 amino acids, between about 30 amino acids to about 80 amino acids, between about 30 amino acids to about 70 amino acids, between about 30 amino acids to about 60 amino acids, between about 30 amino acids to about 50 amino acids, between about 30 amino acids to about 40 amino acids, between about 50 amino acids to about 800 amino acids, between about 50 amino acids to about 790 amino acids, between about 50 amino acids to about 780 amino acids, between about 50 amino acids to about 770 amino acids, between about 50 amino acids to about 760 amino acids, between about 50 amino acids to about 750 amino acids, between about 50 amino acids to about 740 amino acids, between about 50 amino acids to about 730 amino acids, between about 50 amino acids to about 720 amino acids, between about 50 amino acids to about 710 amino acids, between about 50 amino acids to about 700 amino acids, between about 50 amino acids to about 690 amino acids, between about 50 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 50 amino acids to about 660 amino acids, between about 50 amino acids to about 650 amino acids, between about 50 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 50 amino acids to about 620 amino acids, between about 50 amino acids to about 610 amino acids, between about 50 amino acids to about 600 amino acids, between about 50 amino acids to about 590 amino acids, between about 50 amino acids to about 580 amino acids, between about 50 amino acids to about 570 amino acids, between about 50 amino acids to about 560 amino acids, between about 50 amino acids to about 550 amino acids, between about 50 amino acids to about 540 amino acids, between about 50 amino acids to about 530 amino acids, between about 50 amino acids to about 520 amino acids, between about 50 amino acids to about 510 amino acids, between about 50 amino acids to about 500 amino acids, between about 50 amino acids to about 490 amino acids, between about 50 amino acids to about 480 amino acids, between about 50 amino acids to about 470 amino acids, between about 50 amino acids to about 460 amino acids, between about 50 amino acids to about 450 amino acids, between about 50 amino acids to about 440 amino acids, between about 50 amino acids to about 430 amino acids, between about 50 amino acids to about 420 amino acids, between about 50 amino acids to about 410 amino acids, between about 50 amino acids to about 400 amino acids, between about 50 amino acids to about 390 amino acids, between about 50 amino acids to about 380 amino acids, between about 50 amino acids to about 370 amino acids, between about 50 amino acids to about 360 amino acids, between about 50 amino acids to about 350 amino acids, between about 50 amino acids to about 340 amino acids, between about 50 amino acids to about 330 amino acids, between about 50 amino acids to about 320 amino acids, between about 50 amino acids to about 310 amino acids, between about 50 amino acids to about 300 amino acids, between about 50 amino acids to about 290 amino acids, between about 50 amino acids to about 280 amino acids, between about 50 amino acids to about 270 amino acids, between about 50 amino acids to about 260 amino acids, between about 50 amino acids to about 250 amino acids, between about 50 amino acids to about 240 amino acids, between about 50 amino acids to about 230 amino acids, between about 50 amino acids to about 220 amino acids, between about 50 amino acids to about 210 amino acids, between about 50 amino acids to about 200 amino acids, between about 50 amino acids to about 190 amino acids, between about 50 amino acids to about 180 amino acids, between about 50 amino acids to about 170 amino acids, between about 50 amino acids to about 160 amino acids, between about 50 amino acids to about 150 amino acids, between about 50 amino acids to about 140 amino acids, between about 50 amino acids to about 130 amino acids, between about 50 amino acids to about 120 amino acids, between about 50 amino acids to about 110 amino acids, between about 50 amino acids to about 100 amino acids, between about 50 amino acids to about 90 amino acids, between about 50 amino acids to about 80 amino acids, between about 50 amino acids to about 70 amino acids, between about 50 amino acids to about 60 amino acids, between about 80 amino acids to about 800 amino acids, between about 80 amino acids to about 790 amino acids, between about 80 amino acids to about 780 amino acids, between about 80 amino acids to about 770 amino acids, between about 80 amino acids to about 760 amino acids, between about 80 amino acids to about 750 amino acids, between about 80 amino acids to about 740 amino acids, between about 80 amino acids to about 730 amino acids, between about 80 amino acids to about 720 amino acids, between about 80 amino acids to about 710 amino acids, between about 80 amino acids to about 700 amino acids, between about 80 amino acids to about 690 amino acids, between about 80 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 80 amino acids to about 660 amino acids, between about 80 amino acids to about 650 amino acids, between about 80 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 80 amino acids to about 620 amino acids, between about 80 amino acids to about 610 amino acids, between about 80 amino acids to about 600 amino acids, between about 80 amino acids to about 590 amino acids, between about 80 amino acids to about 580 amino acids, between about 80 amino acids to about 570 amino acids, between about 80 amino acids to about 560 amino acids, between about 80 amino acids to about 550 amino acids, between about 80 amino acids to about 540 amino acids, between about 80 amino acids to about 530 amino acids, between about 80 amino acids to about 520 amino acids, between about 80 amino acids to about 510 amino acids, between about 80 amino acids to about 500 amino acids, between about 80 amino acids to about 490 amino acids, between about 80 amino acids to about 480 amino acids, between about 80 amino acids to about 470 amino acids, between about 80 amino acids to about 460 amino acids, between about 80 amino acids to about 450 amino acids, between about 80 amino acids to about 440 amino acids, between about 80 amino acids to about 430 amino acids, between about 80 amino acids to about 420 amino acids, between about 80 amino acids to about 410 amino acids, between about 80 amino acids to about 400 amino acids, between about 80 amino acids to about 390 amino acids, between about 80 amino acids to about 380 amino acids, between about 80 amino acids to about 370 amino acids, between about 80 amino acids to about 360 amino acids, between about 80 amino acids to about 350 amino acids, between about 80 amino acids to about 340 amino acids, between about 80 amino acids to about 330 amino acids, between about 80 amino acids to about 320 amino acids, between about 80 amino acids to about 310 amino acids, between about 80 amino acids to about 300 amino acids, between about 80 amino acids to about 290 amino acids, between about 80 amino acids to about 280 amino acids, between about 80 amino acids to about 270 amino acids, between about 80 amino acids to about 260 amino acids, between about 80 amino acids to about 250 amino acids, between about 80 amino acids to about 240 amino acids, between about 80 amino acids to about 230 amino acids, between about 80 amino acids to about 220 amino acids, between about 80 amino acids to about 210 amino acids, between about 80 amino acids to about 200 amino acids, between about 80 amino acids to about 190 amino acids, between about 80 amino acids to about 180 amino acids, between about 80 amino acids to about 170 amino acids, between about 80 amino acids to about 160 amino acids, between about 80 amino acids to about 150 amino acids, between about 80 amino acids to about 140 amino acids, between about 80 amino acids to about 130 amino acids, between about 80 amino acids to about 120 amino acids, between about 80 amino acids to about 110 amino acids, between about 80 amino acids to about 100 amino acids, between about 100 amino acids to about 800 amino acids, between about 100 amino acids to about 790 amino acids, between about 100 amino acids to about 780 amino acids, between about 100 amino acids to about 770 amino acids, between about 100 amino acids to about 760 amino acids, between about 100 amino acids to about 750 amino acids, between about 100 amino acids to about 740 amino acids, between about 100 amino acids to about 730 amino acids, between about 100 amino acids to about 720 amino acids, between about 100 amino acids to about 710 amino acids, between about 100 amino acids to about 700 amino acids, between about 100 amino acids to about 690 amino acids, between about 100 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 100 amino acids to about 660 amino acids, between about 100 amino acids to about 650 amino acids, between about 100 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 100 amino acids to about 620 amino acids, between about 100 amino acids to about 610 amino acids, between about 100 amino acids to about 600 amino acids, between about 100 amino acids to about 590 amino acids, between about 100 amino acids to about 580 amino acids, between about 100 amino acids to about 570 amino acids, between about 100 amino acids to about 560 amino acids, between about 100 amino acids to about 550 amino acids, between about 100 amino acids to about 540 amino acids, between about 100 amino acids to about 530 amino acids, between about 100 amino acids to about 520 amino acids, between about 100 amino acids to about 510 amino acids, between about 100 amino acids to about 500 amino acids, between about 100 amino acids to about 490 amino acids, between about 100 amino acids to about 480 amino acids, between about 100 amino acids to about 470 amino acids, between about 100 amino acids to about 460 amino acids, between about 100 amino acids to about 450 amino acids, between about 100 amino acids to about 440 amino acids, between about 100 amino acids to about 430 amino acids, between about 100 amino acids to about 420 amino acids, between about 100 amino acids to about 410 amino acids, between about 100 amino acids to about 400 amino acids, between about 100 amino acids to about 390 amino acids, between about 100 amino acids to about 380 amino acids, between about 100 amino acids to about 370 amino acids, between about 100 amino acids to about 360 amino acids, between about 100 amino acids to about 350 amino acids, between about 100 amino acids to about 340 amino acids, between about 100 amino acids to about 330 amino acids, between about 100 amino acids to about 320 amino acids, between about 100 amino acids to about 310 amino acids, between about 100 amino acids to about 300 amino acids, between about 100 amino acids to about 290 amino acids, between about 100 amino acids to about 280 amino acids, between about 100 amino acids to about 270 amino acids, between about 100 amino acids to about 260 amino acids, between about 100 amino acids to about 250 amino acids, between about 100 amino acids to about 240 amino acids, between about 100 amino acids to about 230 amino acids, between about 100 amino acids to about 220 amino acids, between about 100 amino acids to about 210 amino acids, between about 100 amino acids to about 200 amino acids, between about 100 amino acids to about 190 amino acids, between about 100 amino acids to about 180 amino acids, between about 100 amino acids to about 170 amino acids, between about 100 amino acids to about 160 amino acids, between about 100 amino acids to about 150 amino acids, between about 100 amino acids to about 140 amino acids, between about 100 amino acids to about 130 amino acids, between about 100 amino acids to about 120 amino acids, between about 100 amino acids to about 110 amino acids, between about 120 amino acids to about 800 amino acids, between about 120 amino acids to about 790 amino acids, between about 120 amino acids to about 780 amino acids, between about 120 amino acids to about 770 amino acids, between about 120 amino acids to about 760 amino acids, between about 120 amino acids to about 750 amino acids, between about 120 amino acids to about 740 amino acids, between about 120 amino acids to about 730 amino acids, between about 120 amino acids to about 720 amino acids, between about 120 amino acids to about 710 amino acids, between about 120 amino acids to about 700 amino acids, between about 120 amino acids to about 690 amino acids, between about 120 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 120 amino acids to about 660 amino acids, between about 120 amino acids to about 650 amino acids, between about 120 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 120 amino acids to about 620 amino acids, between about 120 amino acids to about 610 amino acids, between about 120 amino acids to about 600 amino acids, between about 120 amino acids to about 590 amino acids, between about 120 amino acids to about 580 amino acids, between about 120 amino acids to about 570 amino acids, between about 120 amino acids to about 560 amino acids, between about 120 amino acids to about 550 amino acids, between about 120 amino acids to about 540 amino acids, between about 120 amino acids to about 530 amino acids, between about 120 amino acids to about 520 amino acids, between about 120 amino acids to about 510 amino acids, between about 120 amino acids to about 500 amino acids, between about 120 amino acids to about 490 amino acids, between about 120 amino acids to about 480 amino acids, between about 120 amino acids to about 470 amino acids, between about 120 amino acids to about 460 amino acids, between about 120 amino acids to about 450 amino acids, between about 120 amino acids to about 440 amino acids, between about 120 amino acids to about 430 amino acids, between about 120 amino acids to about 420 amino acids, between about 120 amino acids to about 410 amino acids, between about 120 amino acids to about 400 amino acids, between about 120 amino acids to about 390 amino acids, between about 120 amino acids to about 380 amino acids, between about 120 amino acids to about 370 amino acids, between about 120 amino acids to about 360 amino acids, between about 120 amino acids to about 350 amino acids, between about 120 amino acids to about 340 amino acids, between about 120 amino acids to about 330 amino acids, between about 120 amino acids to about 320 amino acids, between about 120 amino acids to about 310 amino acids, between about 120 amino acids to about 300 amino acids, between about 120 amino acids to about 290 amino acids, between about 120 amino acids to about 280 amino acids, between about 120 amino acids to about 270 amino acids, between about 120 amino acids to about 260 amino acids, between about 120 amino acids to about 250 amino acids, between about 120 amino acids to about 240 amino acids, between about 120 amino acids to about 230 amino acids, between about 120 amino acids to about 220 amino acids, between about 120 amino acids to about 210 amino acids, between about 120 amino acids to about 200 amino acids, between about 120 amino acids to about 190 amino acids, between about 120 amino acids to about 180 amino acids, between about 120 amino acids to about 170 amino acids, between about 120 amino acids to about 160 amino acids, between about 120 amino acids to about 150 amino acids, between about 120 amino acids to about 140 amino acids, between about 120 amino acids to about 130 amino acids, between about 150 amino acids to about 800 amino acids, between about 150 amino acids to about 790 amino acids, between about 150 amino acids to about 780 amino acids, between about 150 amino acids to about 770 amino acids, between about 150 amino acids to about 760 amino acids, between about 150 amino acids to about 750 amino acids, between about 150 amino acids to about 740 amino acids, between about 150 amino acids to about 730 amino acids, between about 150 amino acids to about 720 amino acids, between about 150 amino acids to about 710 amino acids, between about 150 amino acids to about 700 amino acids, between about 150 amino acids to about 690 amino acids, between about 150 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 150 amino acids to about 660 amino acids, between about 150 amino acids to about 650 amino acids, between about 150 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 150 amino acids to about 620 amino acids, between about 150 amino acids to about 610 amino acids, between about 150 amino acids to about 600 amino acids, between about 150 amino acids to about 590 amino acids, between about 150 amino acids to about 580 amino acids, between about 150 amino acids to about 570 amino acids, between about 150 amino acids to about 560 amino acids, between about 150 amino acids to about 550 amino acids, between about 150 amino acids to about 540 amino acids, between about 150 amino acids to about 530 amino acids, between about 150 amino acids to about 520 amino acids, between about 150 amino acids to about 510 amino acids, between about 150 amino acids to about 500 amino acids, between about 150 amino acids to about 490 amino acids, between about 150 amino acids to about 480 amino acids, between about 150 amino acids to about 470 amino acids, between about 150 amino acids to about 460 amino acids, between about 150 amino acids to about 450 amino acids, between about 150 amino acids to about 440 amino acids, between about 150 amino acids to about 430 amino acids, between about 150 amino acids to about 420 amino acids, between about 150 amino acids to about 410 amino acids, between about 150 amino acids to about 400 amino acids, between about 150 amino acids to about 390 amino acids, between about 150 amino acids to about 380 amino acids, between about 150 amino acids to about 370 amino acids, between about 150 amino acids to about 360 amino acids, between about 150 amino acids to about 350 amino acids, between about 150 amino acids to about 340 amino acids, between about 150 amino acids to about 330 amino acids, between about 150 amino acids to about 320 amino acids, between about 150 amino acids to about 310 amino acids, between about 150 amino acids to about 300 amino acids, between about 150 amino acids to about 290 amino acids, between about 150 amino acids to about 280 amino acids, between about 150 amino acids to about 270 amino acids, between about 150 amino acids to about 260 amino acids, between about 150 amino acids to about 250 amino acids, between about 150 amino acids to about 240 amino acids, between about 150 amino acids to about 230 amino acids, between about 150 amino acids to about 220 amino acids, between about 150 amino acids to about 210 amino acids, between about 150 amino acids to about 200 amino acids, between about 150 amino acids to about 190 amino acids, between about 150 amino acids to about 180 amino acids, between about 150 amino acids to about 170 amino acids, between about 150 amino acids to about 160 amino acids, between about 180 amino acids to about 800 amino acids, between about 180 amino acids to about 790 amino acids, between about 180 amino acids to about 780 amino acids, between about 180 amino acids to about 770 amino acids, between about 180 amino acids to about 760 amino acids, between about 180 amino acids to about 750 amino acids, between about 180 amino acids to about 740 amino acids, between about 180 amino acids to about 730 amino acids, between about 180 amino acids to about 720 amino acids, between about 180 amino acids to about 710 amino acids, between about 180 amino acids to about 700 amino acids, between about 180 amino acids to about 690 amino acids, between about 180 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 180 amino acids to about 660 amino acids, between about 180 amino acids to about 650 amino acids, between about 180 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 180 amino acids to about 620 amino acids, between about 180 amino acids to about 610 amino acids, between about 180 amino acids to about 600 amino acids, between about 180 amino acids to about 590 amino acids, between about 180 amino acids to about 580 amino acids, between about 180 amino acids to about 570 amino acids, between about 180 amino acids to about 560 amino acids, between about 180 amino acids to about 550 amino acids, between about 180 amino acids to about 540 amino acids, between about 180 amino acids to about 530 amino acids, between about 180 amino acids to about 520 amino acids, between about 180 amino acids to about 510 amino acids, between about 180 amino acids to about 500 amino acids, between about 180 amino acids to about 490 amino acids, between about 180 amino acids to about 480 amino acids, between about 180 amino acids to about 470 amino acids, between about 180 amino acids to about 460 amino acids, between about 180 amino acids to about 450 amino acids, between about 180 amino acids to about 440 amino acids, between about 180 amino acids to about 430 amino acids, between about 180 amino acids to about 420 amino acids, between about 180 amino acids to about 410 amino acids, between about 180 amino acids to about 400 amino acids, between about 180 amino acids to about 390 amino acids, between about 180 amino acids to about 380 amino acids, between about 180 amino acids to about 370 amino acids, between about 180 amino acids to about 360 amino acids, between about 180 amino acids to about 350 amino acids, between about 180 amino acids to about 340 amino acids, between about 180 amino acids to about 330 amino acids, between about 180 amino acids to about 320 amino acids, between about 180 amino acids to about 310 amino acids, between about 180 amino acids to about 300 amino acids, between about 180 amino acids to about 290 amino acids, between about 180 amino acids to about 280 amino acids, between about 180 amino acids to about 270 amino acids, between about 180 amino acids to about 260 amino acids, between about 180 amino acids to about 250 amino acids, between about 180 amino acids to about 240 amino acids, between about 180 amino acids to about 230 amino acids, between about 180 amino acids to about 220 amino acids, between about 180 amino acids to about 210 amino acids, between about 180 amino acids to about 200 amino acids, between about 180 amino acids to about 190 amino acids, between about 200 amino acids to about 800 amino acids, between about 200 amino acids to about 790 amino acids, between about 200 amino acids to about 780 amino acids, between about 200 amino acids to about 770 amino acids, between about 200 amino acids to about 760 amino acids, between about 200 amino acids to about 750 amino acids, between about 200 amino acids to about 740 amino acids, between about 200 amino acids to about 730 amino acids, between about 200 amino acids to about 720 amino acids, between about 200 amino acids to about 710 amino acids, between about 200 amino acids to about 700 amino acids, between about 200 amino acids to about 690 amino acids, between about 200 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 200 amino acids to about 660 amino acids, between about 200 amino acids to about 650 amino acids, between about 200 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 200 amino acids to about 620 amino acids, between about 200 amino acids to about 610 amino acids, between about 200 amino acids to about 600 amino acids, between about 200 amino acids to about 590 amino acids, between about 200 amino acids to about 580 amino acids, between about 200 amino acids to about 570 amino acids, between about 200 amino acids to about 560 amino acids, between about 200 amino acids to about 550 amino acids, between about 200 amino acids to about 540 amino acids, between about 200 amino acids to about 530 amino acids, between about 200 amino acids to about 520 amino acids, between about 200 amino acids to about 510 amino acids, between about 200 amino acids to about 500 amino acids, between about 200 amino acids to about 490 amino acids, between about 200 amino acids to about 480 amino acids, between about 200 amino acids to about 470 amino acids, between about 200 amino acids to about 460 amino acids, between about 200 amino acids to about 450 amino acids, between about 200 amino acids to about 440 amino acids, between about 200 amino acids to about 430 amino acids, between about 200 amino acids to about 420 amino acids, between about 200 amino acids to about 410 amino acids, between about 200 amino acids to about 400 amino acids, between about 200 amino acids to about 390 amino acids, between about 200 amino acids to about 380 amino acids, between about 200 amino acids to about 370 amino acids, between about 200 amino acids to about 360 amino acids, between about 200 amino acids to about 350 amino acids, between about 200 amino acids to about 340 amino acids, between about 200 amino acids to about 330 amino acids, between about 200 amino acids to about 320 amino acids, between about 200 amino acids to about 310 amino acids, between about 200 amino acids to about 300 amino acids, between about 200 amino acids to about 290 amino acids, between about 200 amino acids to about 280 amino acids, between about 200 amino acids to about 270 amino acids, between about 200 amino acids to about 260 amino acids, between about 200 amino acids to about 250 amino acids, between about 200 amino acids to about 240 amino acids, between about 200 amino acids to about 230 amino acids, between about 200 amino acids to about 220 amino acids, between about 200 amino acids to about 210 amino acids, between about 250 amino acids to about 800 amino acids, between about 250 amino acids to about 790 amino acids, between about 250 amino acids to about 780 amino acids, between about 250 amino acids to about 770 amino acids, between about 250 amino acids to about 760 amino acids, between about 250 amino acids to about 750 amino acids, between about 250 amino acids to about 740 amino acids, between about 250 amino acids to about 730 amino acids, between about 250 amino acids to about 720 amino acids, between about 250 amino acids to about 710 amino acids, between about 250 amino acids to about 700 amino acids, between about 250 amino acids to about 690 amino acids, between about 250 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 250 amino acids to about 660 amino acids, between about 250 amino acids to about 650 amino acids, between about 250 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 250 amino acids to about 620 amino acids, between about 250 amino acids to about 610 amino acids, between about 250 amino acids to about 600 amino acids, between about 250 amino acids to about 590 amino acids, between about 250 amino acids to about 580 amino acids, between about 250 amino acids to about 570 amino acids, between about 250 amino acids to about 560 amino acids, between about 250 amino acids to about 550 amino acids, between about 250 amino acids to about 540 amino acids, between about 250 amino acids to about 530 amino acids, between about 250 amino acids to about 520 amino acids, between about 250 amino acids to about 510 amino acids, between about 250 amino acids to about 500 amino acids, between about 250 amino acids to about 490 amino acids, between about 250 amino acids to about 480 amino acids, between about 250 amino acids to about 470 amino acids, between about 250 amino acids to about 460 amino acids, between about 250 amino acids to about 450 amino acids, between about 250 amino acids to about 440 amino acids, between about 250 amino acids to about 430 amino acids, between about 250 amino acids to about 420 amino acids, between about 250 amino acids to about 410 amino acids, between about 250 amino acids to about 400 amino acids, between about 250 amino acids to about 390 amino acids, between about 250 amino acids to about 380 amino acids, between about 250 amino acids to about 370 amino acids, between about 250 amino acids to about 360 amino acids, between about 250 amino acids to about 350 amino acids, between about 250 amino acids to about 340 amino acids, between about 250 amino acids to about 330 amino acids, between about 250 amino acids to about 320 amino acids, between about 250 amino acids to about 310 amino acids, between about 250 amino acids to about 300 amino acids, between about 250 amino acids to about 290 amino acids, between about 250 amino acids to about 280 amino acids, between about 250 amino acids to about 270 amino acids, between about 250 amino acids to about 260 amino acids, between about 280 amino acids to about 800 amino acids, between about 280 amino acids to about 790 amino acids, between about 280 amino acids to about 780 amino acids, between about 280 amino acids to about 770 amino acids, between about 280 amino acids to about 760 amino acids, between about 280 amino acids to about 750 amino acids, between about 280 amino acids to about 740 amino acids, between about 280 amino acids to about 730 amino acids, between about 280 amino acids to about 720 amino acids, between about 280 amino acids to about 710 amino acids, between about 280 amino acids to about 700 amino acids, between about 280 amino acids to about 690 amino acids, between about 280 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 280 amino acids to about 660 amino acids, between about 280 amino acids to about 650 amino acids, between about 280 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 280 amino acids to about 620 amino acids, between about 280 amino acids to about 610 amino acids, between about 280 amino acids to about 600 amino acids, between about 280 amino acids to about 590 amino acids, between about 280 amino acids to about 580 amino acids, between about 280 amino acids to about 570 amino acids, between about 280 amino acids to about 560 amino acids, between about 280 amino acids to about 550 amino acids, between about 280 amino acids to about 540 amino acids, between about 280 amino acids to about 530 amino acids, between about 280 amino acids to about 520 amino acids, between about 280 amino acids to about 510 amino acids, between about 280 amino acids to about 500 amino acids, between about 280 amino acids to about 490 amino acids, between about 280 amino acids to about 480 amino acids, between about 280 amino acids to about 470 amino acids, between about 280 amino acids to about 460 amino acids, between about 280 amino acids to about 450 amino acids, between about 280 amino acids to about 440 amino acids, between about 280 amino acids to about 430 amino acids, between about 280 amino acids to about 420 amino acids, between about 280 amino acids to about 410 amino acids, between about 280 amino acids to about 400 amino acids, between about 280 amino acids to about 390 amino acids, between about 280 amino acids to about 380 amino acids, between about 280 amino acids to about 370 amino acids, between about 280 amino acids to about 360 amino acids, between about 280 amino acids to about 350 amino acids, between about 280 amino acids to about 340 amino acids, between about 280 amino acids to about 330 amino acids, between about 280 amino acids to about 320 amino acids, between about 280 amino acids to about 310 amino acids, between about 280 amino acids to about 300 amino acids, between about 300 amino acids to about 800 amino acids, between about 300 amino acids to about 790 amino acids, between about 300 amino acids to about 780 amino acids, between about 300 amino acids to about 770 amino acids, between about 300 amino acids to about 760 amino acids, between about 300 amino acids to about 750 amino acids, between about 300 amino acids to about 740 amino acids, between about 300 amino acids to about 730 amino acids, between about 300 amino acids to about 720 amino acids, between about 300 amino acids to about 710 amino acids, between about 300 amino acids to about 700 amino acids, between about 300 amino acids to about 690 amino acids, between about 300 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 300 amino acids to about 660 amino acids, between about 300 amino acids to about 650 amino acids, between about 300 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 300 amino acids to about 620 amino acids, between about 300 amino acids to about 610 amino acids, between about 300 amino acids to about 600 amino acids, between about 300 amino acids to about 590 amino acids, between about 300 amino acids to about 580 amino acids, between about 300 amino acids to about 570 amino acids, between about 300 amino acids to about 560 amino acids, between about 300 amino acids to about 550 amino acids, between about 300 amino acids to about 540 amino acids, between about 300 amino acids to about 530 amino acids, between about 300 amino acids to about 520 amino acids, between about 300 amino acids to about 510 amino acids, between about 300 amino acids to about 500 amino acids, between about 300 amino acids to about 490 amino acids, between about 300 amino acids to about 480 amino acids, between about 300 amino acids to about 470 amino acids, between about 300 amino acids to about 460 amino acids, between about 300 amino acids to about 450 amino acids, between about 300 amino acids to about 440 amino acids, between about 300 amino acids to about 430 amino acids, between about 300 amino acids to about 420 amino acids, between about 300 amino acids to about 410 amino acids, between about 300 amino acids to about 400 amino acids, between about 300 amino acids to about 390 amino acids, between about 300 amino acids to about 380 amino acids, between about 300 amino acids to about 370 amino acids, between about 300 amino acids to about 360 amino acids, between about 300 amino acids to about 350 amino acids, between about 300 amino acids to about 340 amino acids, between about 300 amino acids to about 330 amino acids, between about 300 amino acids to about 320 amino acids, between about 300 amino acids to about 310 amino acids, between about 350 amino acids to about 800 amino acids, between about 350 amino acids to about 790 amino acids, between about 350 amino acids to about 780 amino acids, between about 350 amino acids to about 770 amino acids, between about 350 amino acids to about 760 amino acids, between about 350 amino acids to about 750 amino acids, between about 350 amino acids to about 740 amino acids, between about 350 amino acids to about 730 amino acids, between about 350 amino acids to about 720 amino acids, between about 350 amino acids to about 710 amino acids, between about 350 amino acids to about 700 amino acids, between about 350 amino acids to about 690 amino acids, between about 350 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 350 amino acids to about 660 amino acids, between about 350 amino acids to about 650 amino acids, between about 350 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 350 amino acids to about 620 amino acids, between about 350 amino acids to about 610 amino acids, between about 350 amino acids to about 600 amino acids, between about 350 amino acids to about 590 amino acids, between about 350 amino acids to about 580 amino acids, between about 350 amino acids to about 570 amino acids, between about 350 amino acids to about 560 amino acids, between about 350 amino acids to about 550 amino acids, between about 350 amino acids to about 540 amino acids, between about 350 amino acids to about 530 amino acids, between about 350 amino acids to about 520 amino acids, between about 350 amino acids to about 510 amino acids, between about 350 amino acids to about 500 amino acids, between about 350 amino acids to about 490 amino acids, between about 350 amino acids to about 480 amino acids, between about 350 amino acids to about 470 amino acids, between about 350 amino acids to about 460 amino acids, between about 350 amino acids to about 450 amino acids, between about 350 amino acids to about 440 amino acids, between about 350 amino acids to about 430 amino acids, between about 350 amino acids to about 420 amino acids, between about 350 amino acids to about 410 amino acids, between about 350 amino acids to about 400 amino acids, between about 350 amino acids to about 390 amino acids, between about 350 amino acids to about 380 amino acids, between about 350 amino acids to about 370 amino acids, between about 350 amino acids to about 360 amino acids, between about 380 amino acids to about 800 amino acids, between about 380 amino acids to about 790 amino acids, between about 380 amino acids to about 780 amino acids, between about 380 amino acids to about 770 amino acids, between about 380 amino acids to about 760 amino acids, between about 380 amino acids to about 750 amino acids, between about 380 amino acids to about 740 amino acids, between about 380 amino acids to about 730 amino acids, between about 380 amino acids to about 720 amino acids, between about 380 amino acids to about 710 amino acids, between about 380 amino acids to about 700 amino acids, between about 380 amino acids to about 690 amino acids, between about 380 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 380 amino acids to about 660 amino acids, between about 380 amino acids to about 650 amino acids, between about 380 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 380 amino acids to about 620 amino acids, between about 380 amino acids to about 610 amino acids, between about 380 amino acids to about 600 amino acids, between about 380 amino acids to about 590 amino acids, between about 380 amino acids to about 580 amino acids, between about 380 amino acids to about 570 amino acids, between about 380 amino acids to about 560 amino acids, between about 380 amino acids to about 550 amino acids, between about 380 amino acids to about 540 amino acids, between about 380 amino acids to about 530 amino acids, between about 380 amino acids to about 520 amino acids, between about 380 amino acids to about 510 amino acids, between about 380 amino acids to about 500 amino acids, between about 380 amino acids to about 490 amino acids, between about 380 amino acids to about 480 amino acids, between about 380 amino acids to about 470 amino acids, between about 380 amino acids to about 460 amino acids, between about 380 amino acids to about 450 amino acids, between about 380 amino acids to about 440 amino acids, between about 380 amino acids to about 430 amino acids, between about 380 amino acids to about 420 amino acids, between about 380 amino acids to about 410 amino acids, between about 380 amino acids to about 400 amino acids, between about 380 amino acids to about 390 amino acids, between about 400 amino acids to about 800 amino acids, between about 400 amino acids to about 790 amino acids, between about 400 amino acids to about 780 amino acids, between about 400 amino acids to about 770 amino acids, between about 400 amino acids to about 760 amino acids, between about 400 amino acids to about 750 amino acids, between about 400 amino acids to about 740 amino acids, between about 400 amino acids to about 730 amino acids, between about 400 amino acids to about 720 amino acids, between about 400 amino acids to about 710 amino acids, between about 400 amino acids to about 700 amino acids, between about 400 amino acids to about 690 amino acids, between about 400 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 400 amino acids to about 660 amino acids, between about 400 amino acids to about 650 amino acids, between about 400 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 400 amino acids to about 620 amino acids, between about 400 amino acids to about 610 amino acids, between about 400 amino acids to about 600 amino acids, between about 400 amino acids to about 590 amino acids, between about 400 amino acids to about 580 amino acids, between about 400 amino acids to about 570 amino acids, between about 400 amino acids to about 560 amino acids, between about 400 amino acids to about 550 amino acids, between about 400 amino acids to about 540 amino acids, between about 400 amino acids to about 530 amino acids, between about 400 amino acids to about 520 amino acids, between about 400 amino acids to about 510 amino acids, between about 400 amino acids to about 500 amino acids, between about 400 amino acids to about 490 amino acids, between about 400 amino acids to about 480 amino acids, between about 400 amino acids to about 470 amino acids, between about 400 amino acids to about 460 amino acids, between about 400 amino acids to about 450 amino acids, between about 400 amino acids to about 440 amino acids, between about 400 amino acids to about 430 amino acids, between about 400 amino acids to about 420 amino acids, between about 400 amino acids to about 410 amino acids, between about 450 amino acids to about 800 amino acids, between about 450 amino acids to about 790 amino acids, between about 450 amino acids to about 780 amino acids, between about 450 amino acids to about 770 amino acids, between about 450 amino acids to about 760 amino acids, between about 450 amino acids to about 750 amino acids, between about 450 amino acids to about 740 amino acids, between about 450 amino acids to about 730 amino acids, between about 450 amino acids to about 720 amino acids, between about 450 amino acids to about 710 amino acids, between about 450 amino acids to about 700 amino acids, between about 450 amino acids to about 690 amino acids, between about 450 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 450 amino acids to about 660 amino acids, between about 450 amino acids to about 650 amino acids, between about 450 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 450 amino acids to about 620 amino acids, between about 450 amino acids to about 610 amino acids, between about 450 amino acids to about 600 amino acids, between about 450 amino acids to about 590 amino acids, between about 450 amino acids to about 580 amino acids, between about 450 amino acids to about 570 amino acids, between about 450 amino acids to about 560 amino acids, between about 450 amino acids to about 550 amino acids, between about 450 amino acids to about 540 amino acids, between about 450 amino acids to about 530 amino acids, between about 450 amino acids to about 520 amino acids, between about 450 amino acids to about 510 amino acids, between about 450 amino acids to about 500 amino acids, between about 450 amino acids to about 490 amino acids, between about 450 amino acids to about 480 amino acids, between about 450 amino acids to about 470 amino acids, between about 450 amino acids to about 460 amino acids, between about 480 amino acids to about 800 amino acids, between about 480 amino acids to about 790 amino acids, between about 480 amino acids to about 780 amino acids, between about 480 amino acids to about 770 amino acids, between about 480 amino acids to about 760 amino acids, between about 480 amino acids to about 750 amino acids, between about 480 amino acids to about 740 amino acids, between about 480 amino acids to about 730 amino acids, between about 480 amino acids to about 720 amino acids, between about 480 amino acids to about 710 amino acids, between about 480 amino acids to about 700 amino acids, between about 480 amino acids to about 690 amino acids, between about 480 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 480 amino acids to about 660 amino acids, between about 480 amino acids to about 650 amino acids, between about 480 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 480 amino acids to about 620 amino acids, between about 480 amino acids to about 610 amino acids, between about 480 amino acids to about 600 amino acids, between about 480 amino acids to about 590 amino acids, between about 480 amino acids to about 580 amino acids, between about 480 amino acids to about 570 amino acids, between about 480 amino acids to about 560 amino acids, between about 480 amino acids to about 550 amino acids, between about 480 amino acids to about 540 amino acids, between about 480 amino acids to about 530 amino acids, between about 480 amino acids to about 520 amino acids, between about 480 amino acids to about 510 amino acids, between about 480 amino acids to about 500 amino acids, between about 480 amino acids to about 490 amino acids, between about 50 amino acids to about 800 amino acids, between about 50 amino acids to about 790 amino acids, between about 50 amino acids to about 780 amino acids, between about 50 amino acids to about 770 amino acids, between about 50 amino acids to about 760 amino acids, between about 50 amino acids to about 750 amino acids, between about 50 amino acids to about 740 amino acids, between about 50 amino acids to about 730 amino acids, between about 50 amino acids to about 720 amino acids, between about 50 amino acids to about 710 amino acids, between about 50 amino acids to about 700 amino acids, between about 50 amino acids to about 690 amino acids, between about 50 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 50 amino acids to about 660 amino acids, between about 50 amino acids to about 650 amino acids, between about 50 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 50 amino acids to about 620 amino acids, between about 50 amino acids to about 610 amino acids, between about 50 amino acids to about 600 amino acids, between about 50 amino acids to about 590 amino acids, between about 50 amino acids to about 580 amino acids, between about 50 amino acids to about 570 amino acids, between about 50 amino acids to about 560 amino acids, between about 50 amino acids to about 550 amino acids, between about 50 amino acids to about 540 amino acids, between about 50 amino acids to about 530 amino acids, between about 50 amino acids to about 520 amino acids, between about 50 amino acids to about 510 amino acids, between about 550 amino acids to about 800 amino acids, between about 550 amino acids to about 790 amino acids, between about 550 amino acids to about 780 amino acids, between about 550 amino acids to about 770 amino acids, between about 550 amino acids to about 760 amino acids, between about 550 amino acids to about 750 amino acids, between about 550 amino acids to about 740 amino acids, between about 550 amino acids to about 730 amino acids, between about 550 amino acids to about 720 amino acids, between about 550 amino acids to about 710 amino acids, between about 550 amino acids to about 700 amino acids, between about 550 amino acids to about 690 amino acids, between about 550 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 550 amino acids to about 660 amino acids, between about 550 amino acids to about 650 amino acids, between about 550 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 550 amino acids to about 620 amino acids, between about 550 amino acids to about 610 amino acids, between about 550 amino acids to about 600 amino acids, between about 550 amino acids to about 590 amino acids, between about 550 amino acids to about 580 amino acids, between about 550 amino acids to about 570 amino acids, between about 550 amino acids to about 560 amino acids, between about 580 amino acids to about 800 amino acids, between about 580 amino acids to about 790 amino acids, between about 580 amino acids to about 780 amino acids, between about 580 amino acids to about 770 amino acids, between about 580 amino acids to about 760 amino acids, between about 580 amino acids to about 750 amino acids, between about 580 amino acids to about 740 amino acids, between about 580 amino acids to about 730 amino acids, between about 580 amino acids to about 720 amino acids, between about 580 amino acids to about 710 amino acids, between about 580 amino acids to about 700 amino acids, between about 580 amino acids to about 690 amino acids, between about 580 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 580 amino acids to about 660 amino acids, between about 580 amino acids to about 650 amino acids, between about 580 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 580 amino acids to about 620 amino acids, between about 580 amino acids to about 610 amino acids, between about 580 amino acids to about 600 amino acids, between about 580 amino acids to about 590 amino acids, between about 600 amino acids to about 800 amino acids, between about 600 amino acids to about 790 amino acids, between about 600 amino acids to about 780 amino acids, between about 600 amino acids to about 770 amino acids, between about 600 amino acids to about 760 amino acids, between about 600 amino acids to about 750 amino acids, between about 600 amino acids to about 740 amino acids, between about 600 amino acids to about 730 amino acids, between about 600 amino acids to about 720 amino acids, between about 600 amino acids to about 710 amino acids, between about 600 amino acids to about 700 amino acids, between about 600 amino acids to about 690 amino acids, between about 600 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 600 amino acids to about 660 amino acids, between about 600 amino acids to about 650 amino acids, between about 600 amino acids to about 640 amino acids, between about 30 amino acids to about 630 amino acids, between about 600 amino acids to about 620 amino acids, between about 600 amino acids to about 610 amino acids, between about 650 amino acids to about 800 amino acids, between about 650 amino acids to about 790 amino acids, between about 650 amino acids to about 780 amino acids, between about 650 amino acids to about 770 amino acids, between about 650 amino acids to about 760 amino acids, between about 650 amino acids to about 750 amino acids, between about 650 amino acids to about 740 amino acids, between about 650 amino acids to about 730 amino acids, between about 650 amino acids to about 720 amino acids, between about 650 amino acids to about 710 amino acids, between about 650 amino acids to about 700 amino acids, between about 650 amino acids to about 690 amino acids, between about 650 amino acids to about 680 amino acids, between 30 amino acids to about 670 amino acids, between about 650 amino acids to about 660 amino acids, between about 680 amino acids to about 800 amino acids, between about 680 amino acids to about 790 amino acids, between about 680 amino acids to about 780 amino acids, between about 680 amino acids to about 770 amino acids, between about 680 amino acids to about 760 amino acids, between about 680 amino acids to about 750 amino acids, between about 680 amino acids to about 740 amino acids, between about 680 amino acids to about 730 amino acids, between about 680 amino acids to about 720 amino acids, between about 680 amino acids to about 710 amino acids, between about 680 amino acids to about 700 amino acids, between about 680 amino acids to about 690 amino acids, between about 700 amino acids to about 800 amino acids, between about 700 amino acids to about 790 amino acids, between about 700 amino acids to about 780 amino acids, between about 700 amino acids to about 770 amino acids, between about 700 amino acids to about 760 amino acids, between about 700 amino acids to about 750 amino acids, between about 700 amino acids to about 740 amino acids, between about 700 amino acids to about 730 amino acids, between about 700 amino acids to about 720 amino acids, between about 700 amino acids to about 710 amino acids, between about 750 amino acids to about 800 amino acids, between about 750 amino acids to about 790 amino acids, between about 750 amino acids to about 780 amino acids, between about 750 amino acids to about 770 amino acids, between about 750 amino acids to about 760 amino acids, or between about 780 amino acids to about 800 amino acids) in length. In some examples, the second vector further includes a poly(A) sequence.

In some examples where the number of different vectors in the composition is two, the N-terminal portion encoded by one of the two vectors can include a portion including amino acid position 1 to about amino acid position 800, about amino acid position 790, about amino acid position 780, about amino acid position 770, about amino acid position 760, about amino acid position 750, about amino acid position 740, about amino acid position 730, about amino acid position 720, about amino acid position 710, about amino acid position 700, about amino acid position 690, about amino acid position 680, about amino acid position 670, about amino acid position 660, about amino acid position 650, about amino acid position 640, about amino acid position 630, about amino acid position 620, about amino acid position 610, about amino acid position 600, about amino acid position 590, about amino acid position 580, about amino acid position 570, about amino acid position 560, about amino acid position 550, about amino acid position 540, about amino acid position 530, about amino acid position 520, about amino acid position 510, about amino acid position 500, about amino acid position 490, about amino acid position 480, about amino acid position 470, about amino acid position 460, about amino acid position 450, about amino acid position 440, about amino acid position 430, about amino acid position 420, about amino acid position 410, about amino acid position 400, about amino acid position 390, about amino acid position 380, about amino acid position 370, about amino acid position 360, about amino acid position 350, about amino acid position 340, about amino acid position 330, about amino acid position 320, about amino acid position 310, about amino acid position 300, about amino acid position 290, about amino acid position 280, about amino acid position 270, about amino acid position 260, about amino acid position 250, about amino acid position 240, about amino acid position 230, about amino acid position 220, about amino acid position 210, about amino acid position 200, about amino acid position 190, about amino acid position 180, about amino acid position 170, about amino acid position 160, about amino acid position 150, about amino acid position 140, about amino acid position 130, about amino acid position 120, about amino acid position 110, about amino acid position 100, about amino acid position 90, about amino acid position 80, about amino acid position 70, about amino acid position 60, about amino acid position 50, or about amino acid position 40 of a wildtype hair cell target protein (e.g., SEQ ID NO: 8, SEQ ID NO: 9, SEQ ID NO: 10, SEQ ID NO: 11, SEQ ID NO: 12, SEQ ID NO: 20, SEQ ID NO: 23, SEQ ID NO: 24, SEQ ID NO: 25, SEQ ID NO: 26, SEQ ID NO: 27, SEQ ID NO: 28, SEQ ID NO: 30, SEQ ID NO: 31, SEQ ID NO: 32, SEQ ID NO: 34, SEQ ID NO: 39, SEQ ID NO: 41, SEQ ID NO: 43, SEQ ID NO: 45, SEQ ID NO: 48, SEQ ID NO: 51, SEQ ID NO: 53, SEQ ID NO: 55, SEQ ID NO: 57, SEQ ID NO: 59, SEQ ID NO: 61, SEQ ID NO: 64, SEQ ID NO: 66, SEQ ID NO: 68, SEQ ID NO: 69, SEQ ID NO: 70, SEQ ID NO: 72, SEQ ID NO: 74, SEQ ID NO: 76, SEQ ID NO: 77, SEQ ID NO: 78, or SEQ ID NO: 79).

In some examples where the number of different vectors in the composition is two, the N-terminal portion of the precursor hair cell target protein can include a portion including amino acid position 1 to amino acid position 300, amino acid position 1 to amino acid position 310, amino acid position 1 to about amino acid position 320, amino acid position 1 to about amino acid position 330, amino acid position 1 to about amino acid position 340, amino acid position 1 to about amino acid position 350, amino acid position 1 to about amino acid position 360, amino acid position 1 to about amino acid position 370, amino acid position 1 to about amino acid position 380, amino acid position 1 to about amino acid position 390, amino acid position 1 to about amino acid position 400, amino acid position 1 to about amino acid position 410, amino acid position 1 to about amino acid position 420, amino acid position 1 to about amino acid position 430, amino acid position 1 to about amino acid position 440, amino acid position 1 to about amino acid position 450, amino acid position 1 to about amino acid position 460, amino acid position 1 to about amino acid position 470, amino acid position 1 to about amino acid position 480, amino acid position 1 to about amino acid position 490, amino acid position 1 to about amino acid position 500, amino acid position 1 to about amino acid position 510, amino acid position 1 to about amino acid position 520, amino acid position 1 to about amino acid position 530, amino acid position 1 to about amino acid position 540, amino acid position 1 to about amino acid position 550, amino acid position 1 to about amino acid position 560, amino acid position 1 to about amino acid position 570, amino acid position 1 to about amino acid position 580, amino acid position 1 to about amino acid position 590, amino acid position 1 to about amino acid position 600, amino acid position 1 to about amino acid position 610, amino acid position 1 to about amino acid position 620, amino acid position 1 to about amino acid position 630, amino acid position 1 to about amino acid position 640, amino acid position 1 to about amino acid position 650, amino acid position 1 to about amino acid position 660, amino acid position 1 to about amino acid position 670, amino acid position 1 to about amino acid position 680, amino acid position 1 to about amino acid position 690, amino acid position 1 to about amino acid position 700, amino acid position 1 to about amino acid position 710, amino acid position 1 to about amino acid position 720, amino acid position 1 to about amino acid position 730, amino acid position 1 to about amino acid position 740, amino acid position 1 to about amino acid position 750, amino acid position 1 to about amino acid position 760, amino acid position 1 to about amino acid position 770, amino acid position 1 to about amino acid position 780, amino acid position 1 to about amino acid position 790, amino acid position 1 to about amino acid position 800 of a wildtype hair cell target protein (e.g., SEQ ID NO: 8, SEQ ID NO: 9, SEQ ID NO: 10, SEQ ID NO: 11, SEQ ID NO: 12, SEQ ID NO: 20, SEQ ID NO: 23, SEQ ID NO: 24, SEQ ID NO: 25, SEQ ID NO: 26, SEQ ID NO: 27, SEQ ID NO: 28, SEQ ID NO: 30, SEQ ID NO: 31, SEQ ID NO: 32, SEQ ID NO: 34, SEQ ID NO: 35, SEQ ID NO: 41, SEQ ID NO: 43, SEQ ID NO: 45, SEQ ID NO: 48, SEQ ID NO: 51, SEQ ID NO: 53, SEQ ID NO: 55, SEQ ID NO: 57, SEQ ID NO: 59, SEQ ID NO: 61, SEQ ID NO: 64, SEQ ID NO: 66, SEQ ID NO: 68, SEQ ID NO: 69, SEQ ID NO: 70, SEQ ID NO: 72, SEQ ID NO: 74, SEQ ID NO: 76, SEQ ID NO: 77, SEQ ID NO: 78, SEQ ID NO: 79).

In some examples where the number of different vectors in the composition is two, the N-terminal portion encoded by one of the two vectors can include a portion including amino acid position 1 to about amino acid position 800, about amino acid position 790, about amino acid position 780, about amino acid position 770, about amino acid position 760, about amino acid position 750, about amino acid position 740, about amino acid position 730, about amino acid position 720, about amino acid position 710, about amino acid position 700, about amino acid position 690, about amino acid position 680, about amino acid position 670, about amino acid position 660, about amino acid position 650, about amino acid position 640, about amino acid position 630, about amino acid position 620, about amino acid position 610, about amino acid position 600, about amino acid position 590, about amino acid position 580, about amino acid position 570, about amino acid position 560, about amino acid position 550, about amino acid position 540, about amino acid position 530, about amino acid position 520, about amino acid position 510, about amino acid position 500, about amino acid position 490, about amino acid position 480, about amino acid position 470, about amino acid position 460, about amino acid position 450, about amino acid position 440, about amino acid position 430, about amino acid position 420, about amino acid position 410, about amino acid position 400, about amino acid position 390, about amino acid position 380, about amino acid position 370, about amino acid position 360, about amino acid position 350, about amino acid position 340, about amino acid position 330, about amino acid position 320, about amino acid position 310, about amino acid position 300, about amino acid position 290, about amino acid position 280, about amino acid position 270, about amino acid position 260, about amino acid position 250, about amino acid position 240, about amino acid position 230, about amino acid position 220, about amino acid position 210, about amino acid position 200, about amino acid position 190, about amino acid position 180, about amino acid position 170, about amino acid position 160, about amino acid position 150, about amino acid position 140, about amino acid position 130, about amino acid position 120, about amino acid position 110, about amino acid position 100, about amino acid position 90, about amino acid position 80, about amino acid position 70, about amino acid position 60, about amino acid position 50, or about amino acid position 40 of a wildtype supporting cell target protein (e.g., SEQ ID NO: 1 or SEQ ID NO: 4).

In some examples where the number of different vectors in the composition is two, the N-terminal portion of the precursor supporting cell target protein can include a portion including amino acid position 1 to amino acid position 300, amino acid position 1 to amino acid position 310, amino acid position 1 to about amino acid position 320, amino acid position 1 to about amino acid position 330, amino acid position 1 to about amino acid position 340, amino acid position 1 to about amino acid position 350, amino acid position 1 to about amino acid position 360, amino acid position 1 to about amino acid position 370, amino acid position 1 to about amino acid position 380, amino acid position 1 to about amino acid position 390, amino acid position 1 to about amino acid position 400, amino acid position 1 to about amino acid position 410, amino acid position 1 to about amino acid position 420, amino acid position 1 to about amino acid position 430, amino acid position 1 to about amino acid position 440, amino acid position 1 to about amino acid position 450, amino acid position 1 to about amino acid position 460, amino acid position 1 to about amino acid position 470, amino acid position 1 to about amino acid position 480, amino acid position 1 to about amino acid position 490, amino acid position 1 to about amino acid position 500, amino acid position 1 to about amino acid position 510, amino acid position 1 to about amino acid position 520, amino acid position 1 to about amino acid position 530, amino acid position 1 to about amino acid position 540, amino acid position 1 to about amino acid position 550, amino acid position 1 to about amino acid position 560, amino acid position 1 to about amino acid position 570, amino acid position 1 to about amino acid position 580, amino acid position 1 to about amino acid position 590, amino acid position 1 to about amino acid position 600, amino acid position 1 to about amino acid position 610, amino acid position 1 to about amino acid position 620, amino acid position 1 to about amino acid position 630, amino acid position 1 to about amino acid position 640, amino acid position 1 to about amino acid position 650, amino acid position 1 to about amino acid position 660, amino acid position 1 to about amino acid position 670, amino acid position 1 to about amino acid position 680, amino acid position 1 to about amino acid position 690, amino acid position 1 to about amino acid position 700, amino acid position 1 to about amino acid position 710, amino acid position 1 to about amino acid position 720, amino acid position 1 to about amino acid position 730, amino acid position 1 to about amino acid position 740, amino acid position 1 to about amino acid position 750, amino acid position 1 to about amino acid position 760, amino acid position 1 to about amino acid position 770, amino acid position 1 to about amino acid position 780, amino acid position 1 to about amino acid position 790, amino acid position 1 to about amino acid position 800 of a wildtype supporting cell target protein (e.g., SEQ ID NO: 1 or SEQ ID NO: 4).

As used herein, the term “vector” means a composition including a polynucleotide capable of carrying at least one exogenous nucleic acid fragment, e.g., a plasmid vector, a transposon, a cosmid, an artificial chromosome (e.g., a human artificial chromosome (HAC), a yeast artificial chromosome (YAC), a bacterial artificial chromosome (BAC), or a P1-derived artificial chromosome (PAC)) or a viral vector (e.g., any adenoviral vectors (e.g., pSV or pCMV vectors), any retroviral vectors as described herein) and any Gateway® vectors. A vector can, e.g., include sufficient cis-acting elements for expression; other elements for expression can be supplied by the host primate cell or in an in vitro expression system. The term “vector” includes any genetic element (e.g., a plasmid, a transposon, a cosmid, an artificial chromosome, or a viral vector, etc.) that is capable of replicating when associated with the proper control elements. Thus, the term includes cloning and expression vectors, as well as viral vectors (e.g., an adeno-associated virus (AAV) vector, an adenovirus vector, a lentivirus vector, or a retrovirus vector).

Vectors include all those known in the art, including cosmids, plasmids (e.g., naked or contained in liposomes) and viruses (e.g., lentiviruses, retroviruses, adenoviruses, and adeno-associated viruses) that incorporate the recombinant polynucleotide. Skilled practitioners will be capable of selecting suitable vectors and primate cells for making any of the nucleic acids described herein.

In some embodiments the vector is a plasmid (i.e. a circular DNA molecule that can autonomously replicate inside a cell). In some embodiments, the vector can be a cosmid (e.g., pWE and sCos series (Wahl et al. (1987), Evans et al. (1989)).

In some embodiments, the vector(s) is a viral vector (e.g., adeno-associated virus, adenovirus, lentivirus, and retrovirus). Non-limiting examples of viral vectors are described herein. In some embodiments, the vector(s) is an adeno-associated viral vector (AAV) (see, e.g., Asokan et al., Mol. Ther. 20: 699-7080, 2012). “Recombinant AAV vectors” or “rAAVs” are typically composed of, at a minimum, a transgene or a portion thereof and a regulatory sequence, and optionally 5′ and 3′ AAV inverted terminal repeats (ITRs). Such a recombinant AAV vector is packaged into a capsid and delivered to a selected target cell (e.g., an outer hair cell).

The AAV sequences of the vector typically include the cis-acting 5′ and 3′ ITR sequences (See, e.g., B. J. Carter, in “Handbook of Parvoviruses”, ed., P. Tijsser, CRC Press, pp. 155 168, 1990). Typical AAV ITR sequences are about 145 nucleotides in length. In some embodiments, at least 75% of a typical ITR sequence (e.g., at least 80%, at least 85%, at least 90%, or at least 95%) is incorporated into the AAV vector. The ability to modify these ITR sequences is within the skill of the art. (See, e.g., texts such as Sambrook et al., “Molecular Cloning. A Laboratory Manual”, 2d ed., Cold Spring Harbor Laboratory, New York, 1989; and K. Fisher et al., J Virol. 70:520 532, 1996). In some embodiments, any of the coding sequences described herein are flanked by 5′ and 3′ AAV ITR sequences in the AAV vectors. The AAV ITR sequences may be obtained from any known AAV, including presently identified AAV types.

AAV vectors as described herein may include any of the regulatory elements described herein (e.g., one or more of a promoter, a polyA sequence, and an IRES).

In some embodiments, the AAV vector is selected from the group consisting of: an AAV1 vector, an AAV2 vector, an AAV3 vector, an AAV4 vector, an AAV5 vector, an AAV6 vector, an AAV7 vector, an AAV8 vector, an AAV9 vector, an AAV2.7m8 vector, an AAV8BP2 vector, and an AAV293 vector. Additional exemplary AAV vectors that can be used herein are known in the art. See, e.g., Kanaan et al., Mol. Ther. Nucleic Acids 8:184-197, 2017; Li et al., Mol. Ther. 16(7): 1252-1260; Adachi et al., Nat. Commun. 5: 3075, 2014; Isgrig et al., Nat. Commun. 10(1): 427, 2019; and Gao et al., J. Virol. 78(12): 6381-6388.

In some embodiments, the vector(s) is an adenovirus (see, e.g., Dmitriev et al. (1998) J. Virol. 72: 9706-9713; and Poulin et al., J. Virol 8: 10074-10086, 2010). In some embodiments, the vector(s) is a retrovirus (see, e.g., Maier et al. (2010) Future Microbiol 5: 1507-23).

The vectors provided herein can be of different sizes. The choice of vector that is used in any of the compositions, kits, and methods described herein may depend on the size of the vector.

In some embodiments, the vector(s) is a plasmid and can include a total length of up to about 1 kb, up to about 2 kb, up to about 3 kb, up to about 4 kb, up to about 5 kb, up to about 6 kb, up to about 7 kb, up to about 8 kb, up to about 9 kb, up to about 10 kb, up to about 11 kb, up to about 12 kb, up to about 13 kb, up to about 14 kb, or up to about 15 kb. In some embodiments, the vector(s) is a plasmid and can have a total length in a range of about 1 kb to about 2 kb, about 1 kb to about 3 kb, about 1 kb to about 4 kb, about 1 kb to about 5 kb, about 1 kb to about 6 kb, about 1 kb to about 7 kb, about 1 kb to about 8 kb, about 1 kb to about 9 kb, about 1 kb to about 10 kb, about 1 kb to about 11 kb, about 1 kb to about 12 kb, about 1 kb to about 13 kb, about 1 kb to about 14 kb, or about 1 kb to about 15 kb.

In some embodiments, the vector(s) is a viral vector and can have a total number of nucleotides of up to 10 kb. In some embodiments, the viral vector(s) can have a total number of nucleotides in the range of about 1 kb to about 2 kb, 1 kb to about 3 kb, about 1 kb to about 4 kb, about 1 kb to about 5 kb, about 1 kb to about 6 kb, about 1 kb to about 7 kb, about 1 kb to about 8 kb, about 1 kb to about 9 kb, about 1 kb to about 10 kb, about 2 kb to about 3 kb, about 2 kb to about 4 kb, about 2 kb to about 5 kb, about 2 kb to about 6 kb, about 2 kb to about 7 kb, about 2 kb to about 8 kb, about 2 kb to about 9 kb, about 2 kb to about 10 kb, about 3 kb to about 4 kb, about 3 kb to about 5 kb, about 3 kb to about 6 kb, about 3 kb to about 7 kb, about 3 kb to about 8 kb, about 3 kb to about 9 kb, about 3 kb to about 10 kb, about 4 kb to about 5 kb, about 4 kb to about 6 kb, about 4 kb to about 7 kb, about 4 kb to about 8 kb, about 4 kb to about 9 kb, about 4 kb to about 10 kb, about 5 kb to about 6 kb, about 5 kb to about 7 kb, about 5 kb to about 8 kb, about 5 kb to about 9 kb, about 5 kb to about 10 kb, about 6 kb to about 7 kb, about 6 kb to about 8 kb, about 6 kb to about 9 kb, about 6 kb to about 10 kb, about 7 kb to about 8 kb, about 7 kb to about 9 kb, about 7 kb to about 10 kb, about 8 kb to about 9 kb, about 8 kb to about 10 kb, or about 9 kb to about 10 kb.

In some embodiments, the vector(s) is a lentivirus and can have a total number of nucleotides of up to 8 kb. In some examples, the lentivirus(es) can have a total number of nucleotides of about 1 kb to about 2 kb, about 1 kb to about 3 kb, about 1 kb to about 4 kb, about 1 kb to about 5 kb, about 1 kb to about 6 kb, about 1 kb to about 7 kb, about 1 kb to about 8 kb, about 2 kb to about 3 kb, about 2 kb to about 4 kb, about 2 kb to about 5 kb, about 2 kb to about 6 kb, about 2 kb to about 7 kb, about 2 kb to about 8 kb, about 3 kb to about 4 kb, about 3 kb to about 5 kb, about 3 kb to about 6 kb, about 3 kb to about 7 kb, about 3 kb to about 8 kb, about 4 kb to about 5 kb, about 4 kb to about 6 kb, about 4 kb to about 7 kb, about 4 kb to about 8 kb, about 5 kb to about 6 kb, about 5 kb to about 7 kb, about 5 kb to about 8 kb, about 6 kb to about 8 kb, about 6 kb to about 7 kb, or about 7 kb to about 8 kb.

In some embodiments, the vector(s) is an adenovirus and can have a total number of nucleotides of up to 8 kb. In some embodiments, the adenovirus(es) can have a total number of nucleotides in the range of about 1 kb to about 2 kb, about 1 kb to about 3 kb, about 1 kb to about 4 kb, about 1 kb to about 5 kb, about 1 kb to about 6 kb, about 1 kb to about 7 kb, about 1 kb to about 8 kb, about 2 kb to about 3 kb, about 2 kb to about 4 kb, about 2 kb to about 5 kb, about 2 kb to about 6 kb, about 2 kb to about 7 kb, about 2 kb to about 8 kb, about 3 kb to about 4 kb, about 3 kb to about 5 kb, about 3 kb to about 6 kb, about 3 kb to about 7 kb, about 3 kb to about 8 kb, about 4 kb to about 5 kb, about 4 kb to about 6 kb, about 4 kb to about 7 kb, about 4 kb to about 8 kb, about 5 kb to about 6 kb, about 5 kb to about 7 kb, about 5 kb to about 8 kb, about 6 kb to about 7 kb, about 6 kb to about 8 kb, or about 7 kb to about 8 kb.

In some embodiments, the vector(s) is an adeno-associated virus (AAV vector) and can include a total number of nucleotides of up to 5 kb. In some embodiments, the AAV vector(s) can include a total number of nucleotides in the range of about 1 kb to about 2 kb, about 1 kb to about 3 kb, about 1 kb to about 4 kb, about 1 kb to about 5 kb, about 2 kb to about 3 kb, about 2 kb to about 4 kb, about 2 kb to about 5 kb, about 3 kb to about 4 kb, about 3 kb to about 5 kb, or about 4 kb to about 5 kb.

In some embodiments of any of the compositions, kits, and methods provided herein, the at least two different vectors can be substantially the same type of vector and may differ in size. In some embodiments, the at least two different vectors can be different types of vector, and may have substantially the same size or have different sizes.

In some embodiments, any of the at least two vectors can have a total number of nucleotides in the range of about 500 nucleotides to about 10,000 nucleotides, about 500 nucleotides to about 9,500 nucleotides, about 500 nucleotides to about 9,000 nucleotides, about 500 nucleotides to about 8,500 nucleotides, about 500 nucleotides to about 8,000 nucleotides, about 500 nucleotides to about 7,800 nucleotides, about 500 nucleotides to about 7,600 nucleotides, about 500 nucleotides to about 7,400 nucleotides, about 500 nucleotides to about 7,200 nucleotides, about 500 nucleotides to about 7,000 nucleotides, about 500 nucleotides to about 6,800 nucleotides, about 500 nucleotides to about 6,600 nucleotides, about 500 nucleotides to about 6,400 nucleotides, about 500 nucleotides to about 6,200 nucleotides, about 500 nucleotides to about 6,000 nucleotides, about 500 nucleotides to about 5,800 nucleotides, about 500 nucleotides to about 5,600 nucleotides, about 500 nucleotides to about 5,400 nucleotides, about 500 nucleotides to about 5,200 nucleotides, about 500 nucleotides to about 5,000 nucleotides, about 500 nucleotides to about 4,800 nucleotides, about 4,600 nucleotides, about 500 nucleotides to about 4,400 nucleotides, about 500 nucleotides to about 4,200 nucleotides, about 500 nucleotides to about 4,000 nucleotides, about 500 nucleotides to about 3,800 nucleotides, about 500 nucleotides to about 3,600 nucleotides, about 500 nucleotides to about 3,400 nucleotides, about 500 nucleotides to about 3,200 nucleotides, about 500 nucleotides to about 3,000 nucleotides, about 500 nucleotides to about 2,800 nucleotides, about 500 nucleotides to about 2,600 nucleotides, about 500 nucleotides to about 2,400 nucleotides, about 500 nucleotides to about 2,200 nucleotides, about 500 nucleotides to about 2,000 nucleotides, about 500 nucleotides to about 1,800 nucleotides, about 500 nucleotides to about 1,600 nucleotides, about 500 nucleotides to about 1,400 nucleotides, about 500 nucleotides to about 1,200 nucleotides, about 500 nucleotides to about 1,000 nucleotides, about 500 nucleotides to about 800 nucleotides, about 800 nucleotides to about 10,000 nucleotides, about 800 nucleotides to about 9,500 nucleotides, about 800 nucleotides to about 9,000 nucleotides, about 800 nucleotides to about 8,500 nucleotides, about 800 nucleotides to about 8,000 nucleotides, about 800 nucleotides to about 7,800 nucleotides, about 800 nucleotides to about 7,600 nucleotides, about 800 nucleotides to about 7,400 nucleotides, about 800 nucleotides to about 7,200 nucleotides, about 800 nucleotides to about 7,000 nucleotides, about 800 nucleotides to about 6,800 nucleotides, about 800 nucleotides to about 6,600 nucleotides, about 800 nucleotides to about 6,400 nucleotides, about 800 nucleotides to about 6,200 nucleotides, about 800 nucleotides to about 6,000 nucleotides, about 800 nucleotides to about 5,800 nucleotides, about 800 nucleotides to about 5,600 nucleotides, about 800 nucleotides to about 5,400 nucleotides, about 800 nucleotides to about 5,200 nucleotides, about 800 nucleotides to about 5,000 nucleotides, about 800 nucleotides to about 4,800 nucleotides, about 800 nucleotides to about 4,600 nucleotides, about 800 nucleotides to about 4,400 nucleotides, about 800 nucleotides to about 4,200 nucleotides, about 800 nucleotides to about 4,000 nucleotides, about 800 nucleotides to about 3,800 nucleotides, about 800 nucleotides to about 3,600 nucleotides, about 800 nucleotides to about 3,400 nucleotides, about 800 nucleotides to about 3,200 nucleotides, about 800 nucleotides to about 3,000 nucleotides, about 800 nucleotides to about 2,800 nucleotides, about 800 nucleotides to about 2,600 nucleotides, about 800 nucleotides to about 2,400 nucleotides, about 800 nucleotides to about 2,200 nucleotides, about 800 nucleotides to about 2,000 nucleotides, about 800 nucleotides to about 1,800 nucleotides, about 800 nucleotides to about 1,600 nucleotides, about 800 nucleotides to about 1,400 nucleotides, about 800 nucleotides to about 1,200 nucleotides, about 800 nucleotides to about 1,000 nucleotides, about 1,000 nucleotides to about 10,000 nucleotides, about 1,000 nucleotides to about 9,000 nucleotides, about 1,000 nucleotides to about 8,500 nucleotides, about 1,000 nucleotides to about 8,000 nucleotides, about 1,000 nucleotides to about 7,800 nucleotides, about 1,000 nucleotides to about 7,600 nucleotides, about 1,000 nucleotides to about 7,400 nucleotides, about 1,000 nucleotides to about 7,200 nucleotides, about 1,000 nucleotides to about 7,000 nucleotides, about 1,000 nucleotides to about 6,800 nucleotides, about 1,000 nucleotides to about 6,600 nucleotides, about 1,000 nucleotides to about 6,400 nucleotides, about 1,000 nucleotides to about 6,200 nucleotides, about 1,000 nucleotides to about 6,000 nucleotides, about 1,000 nucleotides to about 5,800 nucleotides, about 1,000 nucleotides to about 5,600 nucleotides, about 1,000 nucleotides to about 5,400 nucleotides, about 1,000 nucleotides to about 5,200 nucleotides, about 1,000 nucleotides to about 5,000 nucleotides, about 1,000 nucleotides to about 4,800 nucleotides, about 1,000 nucleotides to about 4,600 nucleotides, about 1,000 nucleotides to about 4,400 nucleotides, about 1,000 nucleotides to about 4,200 nucleotides, about 1,000 nucleotides to about 4,000 nucleotides, about 1,000 nucleotides to about 3,800 nucleotides, about 1,000 nucleotides to about 3,600 nucleotides, about 1,000 nucleotides to about 3,400 nucleotides, about 1,000 nucleotides to about 3,200 nucleotides, about 1,000 nucleotides to about 3,000 nucleotides, about 1,000 nucleotides to about 2,600 nucleotides, about 1,000 nucleotides to about 2,400 nucleotides, about 1,000 nucleotides to about 2,200 nucleotides, about 1,000 nucleotides to about 2,000 nucleotides, about 1,000 nucleotides to about 1,800 nucleotides, about 1,000 nucleotides to about 1,600 nucleotides, about 1,000 nucleotides to about 1,400 nucleotides, about 1,000 nucleotides to about 1,200 nucleotides, about 1,200 nucleotides to about 10,000 nucleotides, about 1,200 nucleotides to about 9,500 nucleotides, about 1,200 nucleotides to about 9,000 nucleotides, about 1,200 nucleotides to about 8,500 nucleotides, about 1,200 nucleotides to about 8,000 nucleotides, about 1,200 nucleotides to about 7,800 nucleotides, about 1,200 nucleotides to about 7,600 nucleotides, about 1,200 nucleotides to about 7,400 nucleotides, about 1,200 nucleotides to about 7,200 nucleotides, about 1,200 nucleotides to about 7,000 nucleotides, about 1,200 nucleotides to about 6,800 nucleotides, about 1,200 nucleotides to about 6,600 nucleotides, about 1,200 nucleotides to about 6,400 nucleotides, about 1,200 nucleotides to about 6,200 nucleotides, about 1,200 nucleotides to about 6,000 nucleotides, about 1,200 nucleotides to about 5,800 nucleotides, about 1,200 nucleotides to about 5,600 nucleotides, about 1,200 nucleotides to about 5,400 nucleotides, about 1,200 nucleotides to about 5,000 nucleotides, about 1,200 nucleotides to about 4,800 nucleotides, about 1,200 nucleotides to about 4,600 nucleotides, about 1,200 nucleotides to about 4,400 nucleotides, about 1,200 nucleotides to about 4,200 nucleotides, about 1,200 nucleotides to about 4,000 nucleotides, about 1,200 nucleotides to about 3,800 nucleotides, about 1,200 nucleotides to about 3,600 nucleotides, about 1,200 nucleotides to about 3,400 nucleotides, about 1,200 nucleotides to about 3,200 nucleotides, about 1,200 nucleotides to about 3,000 nucleotides, about 1,200 nucleotides to about 2,800 nucleotides, about 1,200 nucleotides to about 2,600 nucleotides, about 1,200 nucleotides to about 2,400 nucleotides, about 1,200 nucleotides to about 2,200 nucleotides, about 1,200 nucleotides to about 2,000 nucleotides, about 1,200 nucleotides to about 1,800 nucleotides, about 1,200 nucleotides to about 1,600 nucleotides, about 1,200 nucleotides to about 1,400 nucleotides, about 1,400 nucleotides to about 10,000 nucleotides, about 1,400 nucleotides to about 9,500 nucleotides, about 1,400 nucleotides to about 9,000 nucleotides, about 1,400 nucleotides to about 8,500 nucleotides, about 1,400 nucleotides to about 8,000 nucleotides, about 1,400 nucleotides to about 7,800 nucleotides, about 1,400 nucleotides to about 7,600 nucleotides, about 1,400 nucleotides to about 7,400 nucleotides, about 1,400 nucleotides to about 7,200 nucleotides, about 1,400 nucleotides to about 7,000 nucleotides, about 1,400 nucleotides to about 6,800 nucleotides, about 1,400 nucleotides to about 6,600 nucleotides, about 1,400 nucleotides to about 6,400 nucleotides, about 1,400 nucleotides to about 6,200 nucleotides, about 1,400 nucleotides to about 6,000 nucleotides, about 1,400 nucleotides to about 5,800 nucleotides, about 1,400 nucleotides to about 5,600 nucleotides, about 1,400 nucleotides to about 5,400 nucleotides, about 1,400 nucleotides to about 5,200 nucleotides, about 1,400 nucleotides to about 5,000 nucleotides, about 1,400 nucleotides to about 4,800 nucleotides, about 1,400 nucleotides to about 4,600 nucleotides, about 1,400 nucleotides to about 4,400 nucleotides, about 1,400 nucleotides to about 4,200 nucleotides, about 1,400 nucleotides to about 4,000 nucleotides, about 1,400 nucleotides to about 3,800 nucleotides, about 1,400 nucleotides to about 3,600 nucleotides, about 1,400 nucleotides to about 3,400 nucleotides, about 1,400 nucleotides to about 3,200 nucleotides, about 1,400 nucleotides to about 3,000 nucleotides, about 1,400 nucleotides to about 2,600 nucleotides, about 1,400 nucleotides to about 2,400 nucleotides, about 1,400 nucleotides to about 2,200 nucleotides, about 1,400 nucleotides to about 2,000 nucleotides, about 1,400 nucleotides to about 1,800 nucleotides, about 1,400 nucleotides to about 1,600 nucleotides, about 1,600 nucleotides to about 10,000 nucleotides, about 1,600 nucleotides to about 9,500 nucleotides, about 1,600 nucleotides to about 9,000 nucleotides, about 1,600 nucleotides to about 8,500 nucleotides, about 1,600 nucleotides to about 8,000 nucleotides, about 1,600 nucleotides to about 7,800 nucleotides, about 1,600 nucleotides to about 7,600 nucleotides, about 1,600 nucleotides to about 7,400 nucleotides, about 1,600 nucleotides to about 7,200 nucleotides, about 1,600 nucleotides to about 7,000 nucleotides, about 1,600 nucleotides to about 6,800 nucleotides, about 1,600 nucleotides to about 6,400 nucleotides, about 1,600 nucleotides to about 6,200 nucleotides, about 1,600 nucleotides to about 6,000 nucleotides, about 1,600 nucleotides to about 5,800 nucleotides, about 1,600 nucleotides to about 5,600 nucleotides, about 1,600 nucleotides to about 5,400 nucleotides, about 1,600 nucleotides to about 5,200 nucleotides, about 1,600 nucleotides to about 5,000 nucleotides, about 1,600 nucleotides to about 4,800 nucleotides, about 1,600 nucleotides to about 4,600 nucleotides, about 1,600 nucleotides to about 4,400 nucleotides, about 1,600 nucleotides to about 4,200 nucleotides, about 1,600 nucleotides to about 4,000 nucleotides, about 1,600 nucleotides to about 3,800 nucleotides, about 1,600 nucleotides to about 3,600 nucleotides, about 1,600 nucleotides to about 3,400 nucleotides, about 1,600 nucleotides to about 3,200 nucleotides, about 1,600 nucleotides to about 3,000 nucleotides, about 1,600 nucleotides to about 2,800 nucleotides, about 1,600 nucleotides to about 2,600 nucleotides, about 1,600 nucleotides to about 2,400 nucleotides, about 1,600 nucleotides to about 2,200 nucleotides, about 1,600 nucleotides to about 2,000 nucleotides, about 1,600 nucleotides to about 1,800 nucleotides, about 1,800 nucleotides to about 10,000 nucleotides, about 1,800 nucleotides to about 9,500 nucleotides, about 1,800 nucleotides to about 9,000 nucleotides, about 1,800 nucleotides to about 8,500 nucleotides, about 1,800 nucleotides to about 8,000 nucleotides, about 1,800 nucleotides to about 7,800 nucleotides, about 1,800 nucleotides to about 7,600 nucleotides, about 1,800 nucleotides to about 7,400 nucleotides, about 1,800 nucleotides to about 7,200 nucleotides, about 1,800 nucleotides to about 7,000 nucleotides, about 1,800 nucleotides to about 6,800 nucleotides, about 1,800 nucleotides to about 6,600 nucleotides, about 1,800 nucleotides to about 6,400 nucleotides, about 1,800 nucleotides to about 6,200 nucleotides, about 1,800 nucleotides to about 6,000 nucleotides, about 1,800 nucleotides to about 5,800 nucleotides, about 1,800 nucleotides to about 5,600 nucleotides, about 1,800 nucleotides to about 5,400 nucleotides, about 1,800 nucleotides to about 5,200 nucleotides, about 1,800 nucleotides to about 5,000 nucleotides, about 1,800 nucleotides to about 4,800 nucleotides, about 1,800 nucleotides to about 4,600 nucleotides, about 1,800 nucleotides to about 4,400 nucleotides, about 1,800 nucleotides to about 4,200 nucleotides, about 1,800 nucleotides to about 4,000 nucleotides, about 1,800 nucleotides to about 3,800 nucleotides, about 1,800 nucleotides to about 3,600 nucleotides, about 1,800 nucleotides to about 3,400 nucleotides, about 1,800 nucleotides to about 3,200 nucleotides, about 1,800 nucleotides to about 3,000 nucleotides, about 1,800 nucleotides to about 2,800 nucleotides, about 1,800 nucleotides to about 2,600 nucleotides, about 1,800 nucleotides to about 2,400 nucleotides, about 1,800 nucleotides to about 2,200 nucleotides, about 1,800 nucleotides to about 2,000 nucleotides, about 2,000 nucleotides to about 10,000 nucleotides, about 2,000 nucleotides to about 9,500 nucleotides, about 2,000 nucleotides to about 9,000 nucleotides, about 2,000 nucleotides to about 8,500 nucleotides, about 2,000 nucleotides to about 8,000 nucleotides, about 2,000 nucleotides to about 7,800 nucleotides, about 2,000 nucleotides to about 7,600 nucleotides, about 2,000 nucleotides to about 7,400 nucleotides, about 2,000 nucleotides to about 7,200 nucleotides, about 2,000 nucleotides to about 7,000 nucleotides, about 2,000 nucleotides to about 6,800 nucleotides, about 2,000 nucleotides to about 6,600 nucleotides, about 2,000 nucleotides to about 6,400 nucleotides, about 2,000 nucleotides to about 6,200 nucleotides, about 2,000 nucleotides to about 6,000 nucleotides, about 2,000 nucleotides to about 5,800 nucleotides, about 2,000 nucleotides to about 5,600 nucleotides, about 2,000 nucleotides to about 5,400 nucleotides, about 2,000 nucleotides to about 5,200 nucleotides, about 2,000 nucleotides to about 5,000 nucleotides, about 2,000 nucleotides to about 4,800 nucleotides, about 2,000 nucleotides to about 4,600 nucleotides, about 2,000 nucleotides to about 4,400 nucleotides, about 2,000 nucleotides to about 4,200 nucleotides, about 2,000 nucleotides to about 4,000 nucleotides, about 2,000 nucleotides to about 3,800 nucleotides, about 2,000 nucleotides to about 3,600 nucleotides, about 2,000 nucleotides to about 3,400 nucleotides, about 2,000 nucleotides to about 3,200 nucleotides, about 2,000 nucleotides to about 3,000 nucleotides, about 2,000 nucleotides to about 2,800 nucleotides, about 2,000 nucleotides to about 2,600 nucleotides, about 2,000 nucleotides to about 2,400 nucleotides, about 2,000 nucleotides to about 2,200 nucleotides, about 2,200 nucleotides to about 10,000 nucleotides, about 9,500 nucleotides, about 9,000 nucleotides, about 8,500 nucleotides, about 8,000 nucleotides, about 7,800 nucleotides, about 7,600 nucleotides, about 7,400 nucleotides, about 7,200 nucleotides, about 7,000 nucleotides, about 6,800 nucleotides, about 6,600 nucleotides, about 6,400 nucleotides, about 6,200 nucleotides, about 6,000 nucleotides, about 5,800 nucleotides, about 5,600 nucleotides, about 5,400 nucleotides, about 5,200 nucleotides, about 5,000 nucleotides, about 4,800 nucleotides, about 4,600 nucleotides, about 4,400 nucleotides, about 4,200 nucleotides, about 4,000 nucleotides, about 3,800 nucleotides, about 3,600 nucleotides, about 3,400 nucleotides, about 3,200 nucleotides, about 3,000 nucleotides, about 2,800 nucleotides, about 2,600 nucleotides, about 2,400 nucleotides, about 2,400 nucleotides to about 10,000 nucleotides, about 2,400 nucleotides to about 9,500 nucleotides, about 2,400 nucleotides to about 9,000 nucleotides, about 2,400 nucleotides to about 8,500 nucleotides, about 2,400 nucleotides to about 8,000 nucleotides, about 2,400 nucleotides to about 7,800 nucleotides, about 2,400 nucleotides to about 7,600 nucleotides, about 2,400 nucleotides to about 7,400 nucleotides, about 2,400 nucleotides to about 7,200 nucleotides, about 2,400 nucleotides to about 7,000 nucleotides, about 2,400 nucleotides to about 6,800 nucleotides, about 2,400 nucleotides to about 6,600 nucleotides, about 2,400 nucleotides to about 6,400 nucleotides, about 2,400 nucleotides to about 6,200 nucleotides, about 2,400 nucleotides to about 6,000 nucleotides, about 2,400 nucleotides to about 5,800 nucleotides, about 2,400 nucleotides to about 5,600 nucleotides, about 2,400 nucleotides to about 5,400 nucleotides, about 2,400 nucleotides to about 5,200 nucleotides, about 2,400 nucleotides to about 5,000 nucleotides, about 2,400 nucleotides to about 4,800 nucleotides, about 2,400 nucleotides to about 4,600 nucleotides, about 2,400 nucleotides to about 4,400 nucleotides, about 2,400 nucleotides to about 4,200 nucleotides, about 2,400 nucleotides to about 4,000 nucleotides, about 2,400 nucleotides to about 3,800 nucleotides, about 2,400 nucleotides to about 3,600 nucleotides, about 2,400 nucleotides to about 3,400 nucleotides, about 2,400 nucleotides to about 3,200 nucleotides, about 2,400 nucleotides to about 3,000 nucleotides, about 2,400 nucleotides to about 2,800 nucleotides, about 2,400 nucleotides to about 2,600 nucleotides, about 2,600 nucleotides to about 10,000 nucleotides, about 2,600 nucleotides to about 9,500 nucleotides, about 2,600 nucleotides to about 9,000 nucleotides, about 2,600 nucleotides to about 8,500 nucleotides, about 2,600 nucleotides to about 8,000 nucleotides, about 2,600 nucleotides to about 7,800 nucleotides, about 2,600 nucleotides to about 7,600 nucleotides, about 2,600 nucleotides to about 7,400 nucleotides, about 2,600 nucleotides to about 7,200 nucleotides, about 2,600 nucleotides to about 7,000 nucleotides, about 2,600 nucleotides to about 6,800 nucleotides, about 2,600 nucleotides to about 6,600 nucleotides, about 2,600 nucleotides to about 6,400 nucleotides, about 2,600 nucleotides to about 6,200 nucleotides, about 2,600 nucleotides to about 6,000 nucleotides, about 2,600 nucleotides to about 5,800 nucleotides, about 2,600 nucleotides to about 5,600 nucleotides, about 2,600 nucleotides to about 5,400 nucleotides, about 2,600 nucleotides to about 5,200 nucleotides, about 2,600 nucleotides to about 5,000 nucleotides, about 2,600 nucleotides to about 4,800 nucleotides, about 2,600 nucleotides to about 4,600 nucleotides, about 2,600 nucleotides to about 4,400 nucleotides, about 2,600 nucleotides to about 4,200 nucleotides, about 2,600 nucleotides to about 4,000 nucleotides, about 2,600 nucleotides to about 3,800 nucleotides, about 2,600 nucleotides to about 3,600 nucleotides, about 2,600 nucleotides to about 3,400 nucleotides, about 2,600 nucleotides to about 3,200 nucleotides, about 2,600 nucleotides to about 3,000 nucleotides, about 2,600 nucleotides to about 2,800 nucleotides, about 2,800 nucleotides to about 10,000 nucleotides, about 2,800 nucleotides to about 9,500 nucleotides, about 2,800 nucleotides to about 9,000 nucleotides, about 2,800 nucleotides to about 8,500 nucleotides, about 2,800 nucleotides to about 8,000 nucleotides, about 2,800 nucleotides to about 7,800 nucleotides, about 2,800 nucleotides to about 7,600 nucleotides, about 2,800 nucleotides to about 7,400 nucleotides, about 2,800 nucleotides to about 7,200 nucleotides, about 2,800 nucleotides to about 7,000 nucleotides, about 2,800 nucleotides to about 6,800 nucleotides, about 2,800 nucleotides to about 6,600 nucleotides, about 2,800 nucleotides to about 6,400 nucleotides, about 2,800 nucleotides to about 6,200 nucleotides, about 2,800 nucleotides to about 6,000 nucleotides, about 2,800 nucleotides to about 5,800 nucleotides, about 2,800 nucleotides to about 5,600 nucleotides, about 2,800 nucleotides to about 5,400 nucleotides, about 2,800 nucleotides to about 5,200 nucleotides, about 2,800 nucleotides to about 5,000 nucleotides, about 2,800 nucleotides to about 4,800 nucleotides, about 2,800 nucleotides to about 4,600 nucleotides, about 2,800 nucleotides to about 4,400 nucleotides, about 2,800 nucleotides to about 4,200 nucleotides, about 2,800 nucleotides to about 4,000 nucleotides, about 2,800 nucleotides to about 3,800 nucleotides, about 2,800 nucleotides to about 3,600 nucleotides, about 2,800 nucleotides to about 3,400 nucleotides, about 2,800 nucleotides to about 3,200 nucleotides, about 2,800 nucleotides to about 3,000 nucleotides, about 3,000 nucleotides to about 10,000 nucleotides, about 3,000 nucleotides to about 9,500 nucleotides, about 3,000 nucleotides to about 9,000 nucleotides, about 3,000 nucleotides to about 8,500 nucleotides, about 3,000 nucleotides to about 8,000 nucleotides, about 3,000 nucleotides to about 7,800 nucleotides, about 3,000 nucleotides to about 7,600 nucleotides, about 3,000 nucleotides to about 7,400 nucleotides, about 3,000 nucleotides to about 7,200 nucleotides, about 3,000 nucleotides to about 7,000 nucleotides, about 3,000 nucleotides to about 6,800 nucleotides, about 3,000 nucleotides to about 6,600 nucleotides, about 3,000 nucleotides to about 6,400 nucleotides, about 3,000 nucleotides to about 6,200 nucleotides, about 3,000 nucleotides to about 6,000 nucleotides, about 3,000 nucleotides to about 5,800 nucleotides, about 3,000 nucleotides to about 5,600 nucleotides, about 3,000 nucleotides to about 5,400 nucleotides, about 3,000 nucleotides to about 5,200 nucleotides, about 3,000 nucleotides to about 5,000 nucleotides, about 3,000 nucleotides to about 4,800 nucleotides, about 3,000 nucleotides to about 4,600 nucleotides, about 3,000 nucleotides to about 4,400 nucleotides, about 3,000 nucleotides to about 4,200 nucleotides, about 3,000 nucleotides to about 4,000 nucleotides, about 3,000 nucleotides to about 3,800 nucleotides, about 3,000 nucleotides to about 3,600 nucleotides, about 3,000 nucleotides to about 3,400 nucleotides, about 3,000 nucleotides to about 3,200 nucleotides, about 3,200 nucleotides to about 10,000 nucleotides, about 3,200 nucleotides to about 9,500 nucleotides, about 3,200 nucleotides to about 9,000 nucleotides, about 3,200 nucleotides to about 8,500 nucleotides, about 3,200 nucleotides to about 8,000 nucleotides, about 3,200 nucleotides to about 7,800 nucleotides, about 3,200 nucleotides to about 7,600 nucleotides, about 3,200 nucleotides to about 7,400 nucleotides, about 3,200 nucleotides to about 7,200 nucleotides, about 3,200 nucleotides to about 7,000 nucleotides, about 3,200 nucleotides to about 6,800 nucleotides, about 3,200 nucleotides to about 6,600 nucleotides, about 3,200 nucleotides to about 6,400 nucleotides, about 3,200 nucleotides to about 6,200 nucleotides, about 3,200 nucleotides to about 6,000 nucleotides, about 3,200 nucleotides to about 5,800 nucleotides, about 3,200 nucleotides to about 5,600 nucleotides, about 3,200 nucleotides to about 5,400 nucleotides, about 3,200 nucleotides to about 5,200 nucleotides, about 3,200 nucleotides to about 5,000 nucleotides, about 3,200 nucleotides to about 4,800 nucleotides, about 3,200 nucleotides to about 4,600 nucleotides, about 3,200 nucleotides to about 4,400 nucleotides, about 3,200 nucleotides to about 4,200 nucleotides, about 3,200 nucleotides to about 4,000 nucleotides, about 3,200 nucleotides to about 3,800 nucleotides, about 3,200 nucleotides to about 3,600 nucleotides, about 3,200 nucleotides to about 3,400 nucleotides, about 3,400 nucleotides to about 10,000 nucleotides, about 3,400 nucleotides to about 9,500 nucleotides, about 3,400 nucleotides to about 9,000 nucleotides, about 3,400 nucleotides to about 8,500 nucleotides, about 3,400 nucleotides to about 8,000 nucleotides, about 3,400 nucleotides to about 7,800 nucleotides, about 3,400 nucleotides to about 7,600 nucleotides, about 3,400 nucleotides to about 7,400 nucleotides, about 3,400 nucleotides to about 7,200 nucleotides, about 3,400 nucleotides to about 7,000 nucleotides, about 3,400 nucleotides to about 6,800 nucleotides, about 3,400 nucleotides to about 6,600 nucleotides, about 3,400 nucleotides to about 6,400 nucleotides, about 3,400 nucleotides to about 6,200 nucleotides, about 3,400 nucleotides to about 6,000 nucleotides, about 3,400 nucleotides to about 5,800 nucleotides, about 3,400 nucleotides to about 5,600 nucleotides, about 3,400 nucleotides to about 5,400 nucleotides, about 3,400 nucleotides to about 5,200 nucleotides, about 3,400 nucleotides to about 5,000 nucleotides, about 3,400 nucleotides to about 4,800 nucleotides, about 3,400 nucleotides to about 4,600 nucleotides, about 3,400 nucleotides to about 4,400 nucleotides, about 3,400 nucleotides to about 4,200 nucleotides, about 3,400 nucleotides to about 4,000 nucleotides, about 3,400 nucleotides to about 3,800 nucleotides, about 3,400 nucleotides to about 3,600 nucleotides, about 3,600 nucleotides to about 10,000 nucleotides, about 3,600 nucleotides to about 9,500 nucleotides, about 3,600 nucleotides to about 9,000 nucleotides, about 3,600 nucleotides to about 8,500 nucleotides, about 3,600 nucleotides to about 8,000 nucleotides, about 3,600 nucleotides to about 7,800 nucleotides, about 3,600 nucleotides to about 7,600 nucleotides, about 3,600 nucleotides to about 7,400 nucleotides, about 3,600 nucleotides to about 7,200 nucleotides, about 3,600 nucleotides to about 7,000 nucleotides, about 3,600 nucleotides to about 6,800 nucleotides, about 3,600 nucleotides to about 6,600 nucleotides, about 3,600 nucleotides to about 6,400 nucleotides, about 3,600 nucleotides to about 6,200 nucleotides, about 3,600 nucleotides to about 6,000 nucleotides, about 3,600 nucleotides to about 5,800 nucleotides, about 3,600 nucleotides to about 5,600 nucleotides, about 3,600 nucleotides to about 5,400 nucleotides, about 3,600 nucleotides to about 5,200 nucleotides, about 3,600 nucleotides to about 5,000 nucleotides, about 3,600 nucleotides to about 4,800 nucleotides, about 3,600 nucleotides to about 4,600 nucleotides, about 3,600 nucleotides to about 4,400 nucleotides, about 3,600 nucleotides to about 4,200 nucleotides, about 3,600 nucleotides to about 4,000 nucleotides, about 3,600 nucleotides to about 3,800 nucleotides, about 3,800 nucleotides to about 10,000 nucleotides, about 3,800 nucleotides to about 9,500 nucleotides, about 3,800 nucleotides to about 9,000 nucleotides, about 3,800 nucleotides to about 8,500 nucleotides, about 3,800 nucleotides to about 8,000 nucleotides, about 3,800 nucleotides to about 7,800 nucleotides, about 3,800 nucleotides to about 7,600 nucleotides, about 3,800 nucleotides to about 7,400 nucleotides, about 3,800 nucleotides to about 7,200 nucleotides, about 3,800 nucleotides to about 7,000 nucleotides, about 3,800 nucleotides to about 6,800 nucleotides, about 3,800 nucleotides to about 6,600 nucleotides, about 3,800 nucleotides to about 6,400 nucleotides, about 3,800 nucleotides to about 6,200 nucleotides, about 3,800 nucleotides to about 6,000 nucleotides, about 3,800 nucleotides to about 5,800 nucleotides, about 3,800 nucleotides to about 5,600 nucleotides, about 3,800 nucleotides to about 5,400 nucleotides, about 3,800 nucleotides to about 5,200 nucleotides, about 3,800 nucleotides to about 5,000 nucleotides, about 3,800 nucleotides to about 4,800 nucleotides, about 3,800 nucleotides to about 4,600 nucleotides, about 3,800 nucleotides to about 4,200 nucleotides, about 3,800 nucleotides to about 4,000 nucleotides, about 4,000 nucleotides to about 10,000 nucleotides, about 4,000 nucleotides to about 9,500 nucleotides, about 4,000 nucleotides to about 9,000 nucleotides, about 4,000 nucleotides to about 8,500 nucleotides, about 4,000 nucleotides to about 8,000 nucleotides, about 4,000 nucleotides to about 7,800 nucleotides, about 4,000 nucleotides to about 7,600 nucleotides, about 4,000 nucleotides to about 7,400 nucleotides, about 4,000 nucleotides to about 7,200 nucleotides, about 4,000 nucleotides to about 7,000 nucleotides, about 4,000 nucleotides to about 6,800 nucleotides, about 4,000 nucleotides to about 6,600 nucleotides, about 4,000 nucleotides to about 6,400 nucleotides, about 4,000 nucleotides to about 6,200 nucleotides, about 4,000 nucleotides to about 6,000 nucleotides, about 4,000 nucleotides to about 5,800 nucleotides, about 4,000 nucleotides to about 5,600 nucleotides, about 4,000 nucleotides to about 5,400 nucleotides, about 4,000 nucleotides to about 5,200 nucleotides, about 4,000 nucleotides to about 5,000 nucleotides, about 4,000 nucleotides to about 4,800 nucleotides, about 4,000 nucleotides to about 4,600 nucleotides, about 4,000 nucleotides to about 4,400 nucleotides, about 4,000 nucleotides to about 4,200 nucleotides, about 4,200 nucleotides to about 10,000 nucleotides, about 4,200 nucleotides to about 9,500 nucleotides, about 4,200 nucleotides to about 9,000 nucleotides, about 4,200 nucleotides to about 8,500 nucleotides, about 4,200 nucleotides to about 8,000 nucleotides, about 4,200 nucleotides to about 7,800 nucleotides, about 4,200 nucleotides to about 7,600 nucleotides, about 4,200 nucleotides to about 7,400 nucleotides, about 4,200 nucleotides to about 7,200 nucleotides, about 4,200 nucleotides to about 7,000 nucleotides, about 4,200 nucleotides to about 6,800 nucleotides, about 4,200 nucleotides to about 6,600 nucleotides, about 4,200 nucleotides to about 6,400 nucleotides, about 4,200 nucleotides to about 6,200 nucleotides, about 4,200 nucleotides to about 6,000 nucleotides, about 4,200 nucleotides to about 5,800 nucleotides, about 4,200 nucleotides to about 5,600 nucleotides, about 4,200 nucleotides to about 5,400 nucleotides, about 4,200 nucleotides to about 5,200 nucleotides, about 4,200 nucleotides to about 5,000 nucleotides, about 4,200 nucleotides to about 4,800 nucleotides, about 4,200 nucleotides to about 4,600 nucleotides, about 4,200 nucleotides to about 4,400 nucleotides, about 4,400 nucleotides to about 10,000 nucleotides, about 4,400 nucleotides to about 9,500 nucleotides, about 4,400 nucleotides to about 9,000 nucleotides, about 4,400 nucleotides to about 8,500 nucleotides, about 4,400 nucleotides to about 8,000 nucleotides, about 4,400 nucleotides to about 7,800 nucleotides, about 4,400 nucleotides to about 7,600 nucleotides, about 4,400 nucleotides to about 7,400 nucleotides, about 4,400 nucleotides to about 7,200 nucleotides, about 4,400 nucleotides to about 7,000 nucleotides, about 4,400 nucleotides to about 6,800 nucleotides, about 4,400 nucleotides to about 6,600 nucleotides, about 4,400 nucleotides to about 6,400 nucleotides, about 4,400 nucleotides to about 6,200 nucleotides, about 4,400 nucleotides to about 6,000 nucleotides, about 4,400 nucleotides to about 5,800 nucleotides, about 4,400 nucleotides to about 5,600 nucleotides, about 4,400 nucleotides to about 5,400 nucleotides, about 4,400 nucleotides to about 5,200 nucleotides, about 4,400 nucleotides to about 5,000 nucleotides, about 4,400 nucleotides to about 4,800 nucleotides, about 4,400 nucleotides to about 4,600 nucleotides, about 4,600 nucleotides to about 10,000 nucleotides, about 4,600 nucleotides to about 9,500 nucleotides, about 4,600 nucleotides to about 9,000 nucleotides, about 4,600 nucleotides to about 8,500 nucleotides, about 4,600 nucleotides to about 8,000 nucleotides, about 4,600 nucleotides to about 7,800 nucleotides, about 4,600 nucleotides to about 7,600 nucleotides, about 4,600 nucleotides to about 7,400 nucleotides, about 4,600 nucleotides to about 7,200 nucleotides, about 4,600 nucleotides to about 7,000 nucleotides, about 4,600 nucleotides to about 6,800 nucleotides, about 4,600 nucleotides to about 6,600 nucleotides, about 4,600 nucleotides to about 6,400 nucleotides, about 4,600 nucleotides to about 6,200 nucleotides, about 4,600 nucleotides to about 6,000 nucleotides, about 4,600 nucleotides to about 5,800 nucleotides, about 4,600 nucleotides to about 5,600 nucleotides, about 4,600 nucleotides to about 5,400 nucleotides, about 4,600 nucleotides to about 5,200 nucleotides, about 4,600 nucleotides to about 5,000 nucleotides, about 4,600 nucleotides to about 4,800 nucleotides, about 4,800 nucleotides to about 10,000 nucleotides, about 4,800 nucleotides to about 9,500 nucleotides, about 4,800 nucleotides to about 9,000 nucleotides, about 4,800 nucleotides to about 8,500 nucleotides, about 4,800 nucleotides to about 8,000 nucleotides, about 4,800 nucleotides to about 7,800 nucleotides, about 4,800 nucleotides to about 7,600 nucleotides, about 4,800 nucleotides to about 7,400 nucleotides, about 4,800 nucleotides to about 7,200 nucleotides, about 4,800 nucleotides to about 7,000 nucleotides, about 4,800 nucleotides to about 6,800 nucleotides, about 4,800 nucleotides to about 6,600 nucleotides, about 4,800 nucleotides to about 6,400 nucleotides, about 4,800 nucleotides to about 6,200 nucleotides, about 4,800 nucleotides to about 6,000 nucleotides, about 4,800 nucleotides to about 5,800 nucleotides, about 4,800 nucleotides to about 5,600 nucleotides, about 4,800 nucleotides to about 5,400 nucleotides, about 4,800 nucleotides to about 5,200 nucleotides, about 4,800 nucleotides to about 5,000 nucleotides, about 5,000 nucleotides to about 10,000 nucleotides, about 5,000 nucleotides to about 9,500 nucleotides, about 5,000 nucleotides to about 9,000 nucleotides, about 5,000 nucleotides to about 8,500 nucleotides, about 5,000 nucleotides to about 8,000 nucleotides, about 5,000 nucleotides to about 7,800 nucleotides, about 5,000 nucleotides to about 7,600 nucleotides, about 5,000 nucleotides to about 7,400 nucleotides, about 5,000 nucleotides to about 7,200 nucleotides, about 5,000 nucleotides to about 7,000 nucleotides, about 5,000 nucleotides to about 6,800 nucleotides, about 5,000 nucleotides to about 6,600 nucleotides, about 5,000 nucleotides to about 6,400 nucleotides, about 5,000 nucleotides to about 6,200 nucleotides, about 5,000 nucleotides to about 6,000 nucleotides, about 5,000 nucleotides to about 5,800 nucleotides, about 5,000 nucleotides to about 5,600 nucleotides, about 5,000 nucleotides to about 5,400 nucleotides, about 5,000 nucleotides to about 5,200 nucleotides, about 5,200 nucleotides to about 10,000 nucleotides, about 5,200 nucleotides to about 9,500 nucleotides, about 5,200 nucleotides to about 9,000 nucleotides, about 5,200 nucleotides to about 8,500 nucleotides, about 5,200 nucleotides to about 8,000 nucleotides, about 5,200 nucleotides to about 7,800 nucleotides, about 5,200 nucleotides to about 7,600 nucleotides, about 5,200 nucleotides to about 7,400 nucleotides, about 5,200 nucleotides to about 7,200 nucleotides, about 5,200 nucleotides to about 7,000 nucleotides, about 5,200 nucleotides to about 6,800 nucleotides, about 5,200 nucleotides to about 6,600 nucleotides, about 5,200 nucleotides to about 6,400 nucleotides, about 5,200 nucleotides to about 6,200 nucleotides, about 5,200 nucleotides to about 6,000 nucleotides, about 5,200 nucleotides to about 5,800 nucleotides, about 5,200 nucleotides to about 5,600 nucleotides, about 5,200 nucleotides to about 5,400 nucleotides, about 5,400 nucleotides to about 10,000 nucleotides, about 5,400 nucleotides to about 9,500 nucleotides, about 5,400 nucleotides to about 9,000 nucleotides, about 5,400 nucleotides to about 8,500 nucleotides, about 5,400 nucleotides to about 8,000 nucleotides, about 5,400 nucleotides to about 7,800 nucleotides, about 5,400 nucleotides to about 7,600 nucleotides, about 5,400 nucleotides to about 7,400 nucleotides, about 5,400 nucleotides to about 7,200 nucleotides, about 5,400 nucleotides to about 7,000 nucleotides, about 5,400 nucleotides to about 6,800 nucleotides, about 5,400 nucleotides to about 6,600 nucleotides, about 5,400 nucleotides to about 6,400 nucleotides, about 5,400 nucleotides to about 6,200 nucleotides, about 5,400 nucleotides to about 6,000 nucleotides, about 5,400 nucleotides to about 5,800 nucleotides, about 5,400 nucleotides to about 5,600 nucleotides, about 5,600 nucleotides to about 10,000 nucleotides, about 5,600 nucleotides to about 9,500 nucleotides, about 5,600 nucleotides to about 9,000 nucleotides, about 5,600 nucleotides to about 8,500 nucleotides, about 5,600 nucleotides to about 8,000 nucleotides, about 5,600 nucleotides to about 7,800 nucleotides, about 5,600 nucleotides to about 7,600 nucleotides, about 5,600 nucleotides to about 7,400 nucleotides, about 5,600 nucleotides to about 7,200 nucleotides, about 5,600 nucleotides to about 7,000 nucleotides, about 5,600 nucleotides to about 6,800 nucleotides, about 5,600 nucleotides to about 6,600 nucleotides, about 5,600 nucleotides to about 6,400 nucleotides, about 5,600 nucleotides to about 6,200 nucleotides, about 5,600 nucleotides to about 6,000 nucleotides, about 5,600 nucleotides to about 5,800 nucleotides, about 5,800 nucleotides to about 10,000 nucleotides, about 5,800 nucleotides to about 9,500 nucleotides, about 5,800 nucleotides to about 9,000 nucleotides, about 5,800 nucleotides to about 8,500 nucleotides, about 5,800 nucleotides to about 8,000 nucleotides, about 5,800 nucleotides to about 7,800 nucleotides, about 5,800 nucleotides to about 7,600 nucleotides, about 5,800 nucleotides to about 7,400 nucleotides, about 5,800 nucleotides to about 7,200 nucleotides, about 5,800 nucleotides to about 7,000 nucleotides, about 5,800 nucleotides to about 6,800 nucleotides, about 5,800 nucleotides to about 6,600 nucleotides, about 5,800 nucleotides to about 6,400 nucleotides, about 5,800 nucleotides to about 6,200 nucleotides, about 5,800 nucleotides to about 6,000 nucleotides, about 6,000 nucleotides to about 10,000 nucleotides, about 6,000 nucleotides to about 9,500 nucleotides, about 6,000 nucleotides to about 9,000 nucleotides, about 6,000 nucleotides to about 8,500 nucleotides, about 6,000 nucleotides to about 8,000 nucleotides, about 6,000 nucleotides to about 7,800 nucleotides, about 6,000 nucleotides to about 7,600 nucleotides, about 6,000 nucleotides to about 7,400 nucleotides, about 6,000 nucleotides to about 7,200 nucleotides, about 6,000 nucleotides to about 7,000 nucleotides, about 6,000 nucleotides to about 6,800 nucleotides, about 6,000 nucleotides to about 6,600 nucleotides, about 6,000 nucleotides to about 6,400 nucleotides, about 6,000 nucleotides to about 6,200 nucleotides, about 6,200 nucleotides to about 10,000 nucleotides, about 6,200 nucleotides to about 9,000 nucleotides, about 6,200 nucleotides to about 8,500 nucleotides, about 6,200 nucleotides to about 8,000 nucleotides, about 6,200 nucleotides to about 7,800 nucleotides, about 6,200 nucleotides to about 7,600 nucleotides, about 6,200 nucleotides to about 7,400 nucleotides, about 6,200 nucleotides to about 7,200 nucleotides, about 6,200 nucleotides to about 7,000 nucleotides, about 6,200 nucleotides to about 6,800 nucleotides, about 6,200 nucleotides to about 6,600 nucleotides, about 6,200 nucleotides to about 6,400 nucleotides, about 6,400 nucleotides to about 10,000 nucleotides, about 6,400 nucleotides to about 9,500 nucleotides, about 6,400 nucleotides to about 9,000 nucleotides, about 6,400 nucleotides to about 8,500 nucleotides, about 6,400 nucleotides to about 8,000 nucleotides, about 6,400 nucleotides to about 7,800 nucleotides, about 6,400 nucleotides to about 7,600 nucleotides, about 6,400 nucleotides to about 7,400 nucleotides, about 6,400 nucleotides to about 7,200 nucleotides, about 6,400 nucleotides to about 7,000 nucleotides, about 6,400 nucleotides to about 6,800 nucleotides, about 6,400 nucleotides to about 6,600 nucleotides, about 6,600 nucleotides to about 10,000 nucleotides, about 6,600 nucleotides to about 9,500 nucleotides, about 6,600 nucleotides to about 9,000 nucleotides, about 6,600 nucleotides to about 8,500 nucleotides, about 6,600 nucleotides to about 8,000 nucleotides, about 6,600 nucleotides to about 7,800 nucleotides, about 6,600 nucleotides to about 7,600 nucleotides, about 6,600 nucleotides to about 7,400 nucleotides, about 6,600 nucleotides to about 7,200 nucleotides, about 6,600 nucleotides to about 7,000 nucleotides, about 6,600 nucleotides to about 6,800 nucleotides, about 6,800 nucleotides to about 10,000 nucleotides, about 6,800 nucleotides to about 9,500 nucleotides, about 6,800 nucleotides to about 9,000 nucleotides, about 6,800 nucleotides to about 8,500 nucleotides, about 6,800 nucleotides to about 8,000 nucleotides, about 6,800 nucleotides to about 7,800 nucleotides, about 6,800 nucleotides to about 7,600 nucleotides, about 6,800 nucleotides to about 7,400 nucleotides, about 6,800 nucleotides to about 7,200 nucleotides, about 6,800 nucleotides to about 7,000 nucleotides, about 7,000 nucleotides to about 10,000 nucleotides, about 7,000 nucleotides to about 9,500 nucleotides, about 7,000 nucleotides to about 9,000 nucleotides, about 7,000 nucleotides to about 8,500 nucleotides, about 7,000 nucleotides to about 8,000 nucleotides, about 7,000 nucleotides to about 7,800 nucleotides, about 7,000 nucleotides to about 7,600 nucleotides, about 7,000 nucleotides to about 7,400 nucleotides, about 7,000 nucleotides to about 7,200 nucleotides, about 7,200 nucleotides to about 10,000 nucleotides, about 7,200 nucleotides to about 9,500 nucleotides, about 7,200 nucleotides to about 9,000 nucleotides, about 7,200 nucleotides to about 8,500 nucleotides, about 7,200 nucleotides to about 8,000 nucleotides, about 7,200 nucleotides to about 7,800 nucleotides, about 7,200 nucleotides to about 7,600 nucleotides, about 7,200 nucleotides to about 7,400 nucleotides, about 7,400 nucleotides to about 10,000 nucleotides, about 7,400 nucleotides to about 9,500 nucleotides, about 7,400 nucleotides to about 9,000 nucleotides, about 7,400 nucleotides to about 8,500 nucleotides, about 7,400 nucleotides to about 8,000 nucleotides, about 7,400 nucleotides to about 7,800 nucleotides, about 7,400 nucleotides to about 7,600 nucleotides, about 7,600 nucleotides to about 10,000 nucleotides, about 7,600 nucleotides to about 9,500 nucleotides, about 7,600 nucleotides to about 9,000 nucleotides, about 7,600 nucleotides to about 8,500 nucleotides, about 7,600 nucleotides to about 8,000 nucleotides, about 7,600 nucleotides to about 7,800 nucleotides, about 7,800 nucleotides to about 10,000 nucleotides, about 7,800 nucleotides to about 9,500 nucleotides, about 7,800 nucleotides to about 9,000 nucleotides, about 7,800 nucleotides to about 8,500 nucleotides, about 7,800 nucleotides to about 8,000 nucleotides, about 8,000 nucleotides to about 10,000 nucleotides, about 8,000 nucleotides to about 9,500 nucleotides, about 8,000 nucleotides to about 9,000 nucleotides, about 8,000 nucleotides to about 8,500 nucleotides, about 8,500 nucleotides to about 10,000 nucleotides, about 8,500 nucleotides to about 9,500 nucleotides, about 8,500 nucleotides to about 9,000 nucleotides, about 9,000 nucleotides to about 10,000 nucleotides, about 9,000 nucleotides to about 9,500 nucleotides, or about 9,500 nucleotides to about 10,000 nucleotides (inclusive).

A variety of different methods known in the art can be used to introduce any of vectors disclosed herein into a primate cell (e.g., a supporting cochlear outer hair cell or a hair cell (e.g., an inner hair cell or an outer hair cell). Non-limiting examples of methods for introducing nucleic acid into a primate cell include: lipofection, transfection (e.g., calcium phosphate transfection, transfection using highly branched organic compounds, transfection using cationic polymers, dendrimer-based transfection, optical transfection, particle-based transfection (e.g., nanoparticle transfection), or transfection using liposomes (e.g., cationic liposomes)), microinjection, electroporation, cell squeezing, sonoporation, protoplast fusion, impalefection, hydrodynamic delivery, gene gun, magnetofection, viral transfection, and nucleofection.

Skilled practitioners will appreciate that any of the vectors described herein can be introduced into a primate cell by, for example, lipofection.

Various molecular biology techniques that can be used to introduce a mutation(s) and/or a deletion(s) into an endogenous gene are also known in the art. Non-limiting examples of such techniques include site-directed mutagenesis, CRISPR (e.g., CRISPR/Cas9-induced knock-in mutations and CRISPR/Cas9-induced knock-out mutations), TALENs, and base editing (Rees & Lui, Nature Rev. Genetics 19: 770-788, 2018; Eid et al., Biochem J. 475(11): 1955-1964, 2018). These methods can be used to correct the sequence of a defective endogenous gene present in a chromosome of a target cell.

Any of the vectors described herein can further include a control sequence, e.g., a control sequence selected from the group of a transcription initiation sequence, a transcription termination sequence, a promoter sequence, an enhancer sequence, an RNA splicing sequence, a polyadenylation (polyA) sequence, and a Kozak consensus sequence. Non-limiting examples of these control sequences are described herein. In some embodiments, a promoter can be a native promoter, a constitutive promoter, an inducible promoter, and/or a tissue-specific promoter.

Some embodiments of any of the compositions and kits described herein can include any combination of the AAV vectors described herein. Some embodiments of any of the methods described herein can include the use of any combination of the AAV vectors described herein.

Promoters

The term “promoter” means a DNA sequence recognized by enzymes/proteins in a primate cell required to initiate the transcription of a specific gene (e.g., a supporting cell target gene or a hair cell target gene). A promoter typically refers to, e.g., a nucleotide sequence to which an RNA polymerase and/or any associated factor binds and at which transcription is initiated. Non-limiting examples of promoters are described herein. Additional examples of promoters are known in the art.

In some embodiments, a vector encoding an N-terminal portion of a hair cell target protein (e.g., a human hair cell target protein) or a hair cell target protein can include a promoter and/or an enhancer. The vector encoding the N-terminal portion of the hair cell target protein or a hair cell target protein can include any of the promoters and/or enhancers described herein or known in the art.

In some embodiments, a vector encoding an N-terminal portion of a supporting cell target protein (e.g., a human supporting cell target protein) or a supporting cell target protein can include a promoter and/or an enhancer. The vector encoding the N-terminal portion of the supporting cell target protein or a supporting cell target protein can include any of the promoters and/or enhancers described herein or known in the art.

In some embodiments, the promoter is an inducible promoter, a constitutive promoter, a primate cell promoter, a viral promoter, a chimeric promoter, an engineered promoter, a tissue-specific promoter, or any other type of promoter known in the art. In some embodiments, the promoter is a RNA polymerase II promoter, such as a primate RNA polymerase II promoter. In some embodiments, the promoter is a RNA polymerase III promoter, including, but not limited to, a H1 promoter, a human U6 promoter, a mouse U6 promoter, or a swine U6 promoter. The promoter will generally be one that is able to promote transcription in cochlear cells such as hair cells. In some examples, the promoter is a cochlea-specific promoter or a cochlea-oriented promoter.

A variety of promoters are known in the art that can be used herein. Non-limiting examples of promoters that can be used herein include: human EF1a, human cytomegalovirus (CMV) (U.S. Pat. No. 5,168,062), human ubiquitin C (UBC), mouse phosphoglycerate kinase 1, polyoma adenovirus, simian virus 40 (SV40), β-globin, β-actin, α-fetoprotein, γ-globin, β-interferon, γ-glutamyl transferase, mouse mammary tumor virus (MMTV), Rous sarcoma virus, rat insulin, glyceraldehyde-3-phosphate dehydrogenase, metallothionein II (MT II), amylase, cathepsin, MI muscarinic receptor, retroviral LTR (e.g. human T-cell leukemia virus HTLV), AAV ITR, interleukin-2, collagenase, platelet-derived growth factor, adenovirus 5 E2, stromelysin, murine MX gene, glucose regulated proteins (GRP78 and GRP94), α-2-macroglobulin, vimentin, MHC class I gene H-2κb, HSP70, proliferin, tumor necrosis factor, thyroid stimulating hormone a gene, immunoglobulin light chain, T-cell receptor, HLA DQα and DQβ, interleukin-2 receptor, MHC class II, MHC class II HLA-DRα, muscle creatine kinase, prealbumin (transthyretin), elastase I, albumin gene, c-fos, c-HA-ras, neural cell adhesion molecule (NCAM), H2B (TH2B) histone, rat growth hormone, human serum amyloid (SAA), troponin I (TN I), duchenne muscular dystrophy, human immunodeficiency virus, and Gibbon Ape Leukemia Virus (GALV) promoters. Additional examples of promoters are known in the art. See, e.g., Lodish, Molecular Cell Biology, Freeman and Company, New York 2007. In some embodiments, the promoter is the CMV immediate early promoter. In some embodiments, the promoter is a CAG promoter or a CAG/CBA promoter.

The term “constitutive” promoter refers to a nucleotide sequence that, when operably linked with a nucleic acid encoding a target protein (e.g., a supporting cell target protein, a hair cell target protein), causes RNA to be transcribed from the nucleic acid in a primate cell under most or all physiological conditions.

Examples of constitutive promoters include, without limitation, the retroviral Rous sarcoma virus (RSV) LTR promoter, the cytomegalovirus (CMV) promoter (see, e.g., Boshart et al, Cell 41:521-530, 1985), the SV40 promoter, the dihydrofolate reductase promoter, the beta-actin promoter, the phosphoglycerol kinase (PGK) promoter, and the EF1-alpha promoter (Invitrogen).

Inducible promoters allow regulation of gene expression and can be regulated by exogenously supplied compounds, environmental factors such as temperature, or the presence of a specific physiological state, e.g., acute phase, a particular differentiation state of the cell, or in replicating cells only. Inducible promoters and inducible systems are available from a variety of commercial sources, including, without limitation, Invitrogen, Clontech, and Ariad. Additional examples of inducible promoters are known in the art.

Examples of inducible promoters regulated by exogenously supplied compounds include the zinc-inducible sheep metallothionine (MT) promoter, the dexamethasone (Dex)-inducible mouse mammary tumor virus (MMITV) promoter, the T7 polymerase promoter system (WO 98/10088); the ecdysone insect promoter (No et al, Proc. Natl. Acad. Sci. U.S.A. 93:3346-3351, 1996), the tetracycline-repressible system (Gossen et al, Proc. Natl. Acad. Sci. U.S.A. 89:5547-5551, 1992), the tetracycline-inducible system (Gossen et al, Science 268:1766-1769, 1995, see also Harvey et al, Curr. Opin. Chem. Biol. 2:512-518, 1998), the RU486-inducible system (Wang et al, Nat. Biotech. 15:239-243, 1997) and Wang et al, Gene Ther. 4:432-441, 1997), and the rapamycin-inducible system (Magari et al. J. Clin. Invest. 100:2865-2872, 1997).

The term “tissue-specific” promoter refers to a promoter that is active only in certain specific cell types and/or tissues (e.g., transcription of a specific gene occurs only within cells expressing transcription regulatory proteins that bind to the tissue-specific promoter).

In some embodiments, the regulatory sequences impart tissue-specific gene expression capabilities. In some cases, the tissue-specific regulatory sequences bind tissue-specific transcription factors that induce transcription in a tissue-specific manner.

Exemplary tissue-specific promoters include but are not limited to the following: a liver-specific thyroxin binding globulin (TBG) promoter, an insulin promoter, a glucagon promoter, a somatostatin promoter, a pancreatic polypeptide (PPY) promoter, a synapsin-1 (Syn) promoter, a creatine kinase (MCK) promoter, a primate desmin (DES) promoter, an alpha-myosin heavy chain (a-MHC) promoter, and a cardiac Troponin T (cTnT) promoter. Additional exemplary promoters include Beta-actin promoter, hepatitis B virus core promoter (Sandig et al., Gene Ther. 3:1002-1009, 1996), alpha-fetoprotein (AFP) promoter (Arbuthnot et al., Hum. Gene Ther. 7:1503-1514, 1996), bone osteocalcin promoter (Stein et al., Mol. Biol. Rep. 24:185-196, 1997); bone sialoprotein promoter (Chen et al., J. Bone Miner. Res. 11:654-664, 1996), CD2 promoter (Hansal et al., J. Immunol. 161:1063-1068, 1998); immunoglobulin heavy chain promoter; T cell receptor alpha-chain promoter, neuronal such as neuron-specific enolase (NSE) promoter (Andersen et al., Cell. Mol. Neurobiol. 13:503-515, 1993), neurofilament light-chain gene promoter (Piccioli et al., Proc. Natl. Acad. Sci. U.S.A. 88:5611-5615, 1991), and the neuron-specific vgf gene promoter (Piccioli et al., Neuron 15:373-384, 1995).

In some embodiments, the tissue-specific promoter is a cochlea-specific promoter. In some embodiments, the tissue-specific promoter is a cochlear hair cell-specific promoter. Non-limiting examples of cochlear hair cell-specific promoters include but are not limited to: a ATOH1 promoter, a POU4F3 promoter, a LHX3 promoter, a MYO7A promoter, a MYO6 promoter, a α9ACHR promoter, and a α10ACHR promoter. In some embodiments, the promoter is an outer hair cell-specific promoter such as a PRESTIN promoter or an ONCOMOD promoter. See, e.g., Zheng et al., Nature 405:149-155, 2000; Tian et al. Dev. Dyn. 231:199-203, 2004; and Ryan et al., Adv. Otorhinolaryngol. 66: 99-115, 2009.

In some embodiments of any of the AAV vectors described herein, the AAV vector includes a human ATOH1 enhancer-promoter (SEQ ID NO: 84).

Human ATOH1 enhancer-promoter

(SEQ ID NO: 84)

ctatggagtttgcataacaaacgtttggcagctcgctctottacactccattaacaagctgtaacatatag

ctgcaggttgctataatctcattaatattttggaaacttgaatattgagtatttctgagtgctcattcccc

atatgccagccacttctgccatgctgactggttcctttctctccattattagcaattagcttcttaccttc

caaagtcagatccaaggtatccaagatactagcaaaggaatcaactatgtgtgcaagttaagcatgcttaa

tatcacccaaacaaacaaagaggcagcatttcttaaagtaatgaagatagataaatcgggttagtcctttg

cgacactgctggtgctttctagagttttatatattttaagcagcttgctttatattctgtctttgcctccc

accccaccagcacttttatttgtggagggttttggctcgccacactttgggaaacttatttgatttcacgg

agagctgaaggaagatcatttttggcaacagacaagtttaaacacgatttctatgggacattgctaactgg

ggcccctaaggagaaaggggaaactgagcggagaatgggttaaatccttggaagcaggggagaggcagggg

aggagagaagtcggaggagtataaagaaaaggacaggaaccaagaagcgtgggggtggtttgccgtaatgt

gagtgtttcttaattagagaacggttgacaatagagggtctggcagaggctcctggccgcggtgcggagcg

tctggagcggagcacgcgctgtcagctggtgagcgcactctcctttcaggcagctccccggggagctgtgc

ggccacatttaacaccatcatcacccctccccggcctcctcaacctcggcctcctcctcgtcgacagcctt

ccttggcccccaccagcagagctcacagtagcgagcgtctctcgccgtctcccgcactcggccggggcctc

tctcctcccccagctgcgcagcgggagccgccactgcccactgcacctcccagcaaccagcccagcacgca

aagaagctgcgcaaagttaaagccaagcaatgccaaggggaggggaagctggaggcgggctttgagtggct

tctgggcgcctggcgggtccagaatcgcccagagccgcccgcggtcgtgcacatctgacccgagtcagctt

gggcaccagccgagagccggctccgcaccgctcccgcaccccagccgccggggtggtgacacacaccggag

tcgaattacagccctgcaattaacatatgaatctgacgaatttaaaagaaggaaaaaaaaaaaaaaacctg

agcaggcttgggagtcctctgcacacaagaacttttctcggggtgtaaaaactctttgattggctgctcgc

acgcgcctgcccgcgccctccattggctgagaagacacgcgaccggcgcgaggagggggttgggagaggag

cggggggagactgagtggcgcgtgccgctttttaaaggggcgcagcgccttcagcaaccggagaagcatag

ttgcacgcgacctggtgtgtgatctccgagtgggtgggggagggtcgaggagggaaaaaaaaataagacgt

tgcagaagagacccggaaagggccttttttttggttgagctggtgtcccagtgctgcctccgatcctgagc

ctccgagcctttgcagtgcaa

Enhancers and 5′ Cap

In some instances, a vector can include a promoter sequence and/or an enhancer sequence. The term “enhancer” refers to a nucleotide sequence that can increase the level of transcription of a nucleic acid encoding a protein of interest (e.g., a supporting cell target protein or a hair cell target protein). Enhancer sequences (50-1500 basepairs in length) generally increase the level of transcription by providing additional binding sites for transcription-associated proteins (e.g., transcription factors). In some embodiments, an enhancer sequence is found within an intronic sequence. Unlike promoter sequences, enhancer sequences can act at much larger distance away from the transcription start site (e.g., as compared to a promoter). Non-limiting examples of enhancers include a RSV enhancer, a CMV enhancer, and a SV40 enhancer.

Destabilizing Domain (DD)

Any of the AAV vectors provided herein can optionally include a sequence encoding a destabilizing domain (“a destabilizing sequence”) for temporal control of protein expression. Non-limiting examples of destabilizing sequences include sequences encoding: a FK506 sequence, a dihydrofolate reductase (DHFR) sequence.

Exemplary DHFR destabilizing sequence

(SEQ ID NO: 85):

MISLIAALAVDYVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPSTDDR

VTWVKSVDEAIAACGDVPEIMVIGGGRVIEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVESEFHD

ADAQNSHSYCFEILERR

Exemplary DHFR destabilizing domain sequence

(SEQ ID NO: 86)

ggtaccatcagtotgattqcggcgttagoggtagattacgttatoggcatggaaaacgccatgccgtggaa

cctqcctqccgatctcgcctggtttaaacgcaacaccttaaataaacccgtgattatgggccgccatacct

gggaatcaatoggtcgtccgttgccaggacgcaaaaatattatcctcagcagtcaaccgagtacggacgat

cgcgtaacgtgggtgaagtoggtggatgaagccatcgcggcgtgtggtgacgtaccagaaatcatggtgat

tggcggcggtcgcgttattgaacagttottgccaaaagcgcaaaaactqtatctgacgcatatcgacgcag

aagtggaaggcgacacccatttccoggattacgagccggatgactgggaatcggtattcagcgaattccac

gatqctgatqcgcagaactotcacagctattgotttgagattctggagoggcgataa

In some embodiments of any of the AAV vectors described herein, the AAV vector includes a destabilizing domain (SEQ ID NO: 87).

Exemplary destabilizing domain

(SEQ ID NO: 87)

atcagtctgattgoggcgttagcggtagattacgttatcggcatggaaaacgccatgccgtggaacctgcc

tgccgatctcgcctggtttaaacgcaacaccttaaataaacccgtgattatgggccgccatacctgggaat

caatcggtcgtccgttgccaggacgcaaaaatattatcctcagcagtcaaccgagtacggacgatcgcgta

acgtgggtgaagtcggtggatgaagccatcgcggcgtgtggtgacgtaccagaaatcatggtgattggcgg

cggtcgcgttattgaacagttcttgccaaaagcgcaaaaactgtatctgacgcatatcgacgcagaagtgg

aaggcgacacccatttcccggattacgagccggatgactgggaatcggtattcagcgaattccacgatgct

gatgcgcagaactctcacagctattgctttgagattctggagcggcga

Additional examples of destabilizing sequences are known in the art. In some embodiments, the destabilizing sequence is a FK506- and rapamycin-binding protein (FKBP12) sequence, and the stabilizing ligand is Shield-1 (Shld1) (Banaszynski et al. (2012) Cell 126(5): 995-1004).

Exemplary FKBP12 destabilizing sequence

(SEQ ID NO: 88)

MGVEKQVIRPGNGPKPAPGQTVTVHCTGEGKDGDLSQKFWSTKDEGQKPFSFQIGKGAVIKGWDEGVIGMQ

IGEVARLRCSSDYAYGAGGFPAWGIQPNSVLDFEIEVLSVQ

In some embodiments, the destabilizing sequence is a DHFR sequence, and the stabilizing ligand is trimethoprim (IMP) (Iwamoto et al. (2010) Chem Biol 17:981-988).

In the absence of a stabilizing ligand, the protein sequence operatively linked to the destabilizing sequence is degraded by ubiquitination. In contrast, in the presence of a stabilizing ligand, protein degradation is inhibited, thereby allowing the protein sequence operatively linked to the destabilizing sequence to be actively expressed. As a positive control for stabilization of protein expression, protein expression can be detected by conventional means, including enzymatic, radiographic, colorimetric, fluorescence, or other spectrographic assays; fluorescent activating cell sorting (FACS) assays; immunological assays (e.g., enzyme linked immunosorbent assay (ELISA), radioimmunoassay (RIA), and immunohistochemistry).

In some embodiments, the destabilizing sequence is a FKBP12 sequence, and the presence of an AAV vector carrying the FKBP12 gene in a primate cell (e.g., a supporting cochlear outer hair cell) is detected by western blotting. In some embodiments, the destabilizing sequence can be used to verify the temporally-specific activity of any of the AAV vectors described herein.

Poly(A) Sequences

In some embodiments, any of the vectors provided herein can include a poly(A) sequence. Most nascent eukaryotic mRNAs possess a poly(A) tail at their 3′ end which is added during a complex process that includes cleavage of the primary transcript and a coupled polyadenylation reaction (see, e.g., Proudfoot et al., Cell 108:501-512, 2002). The poly(A) tail confers mRNA stability and transferability (Molecular Biology of the Cell, Third Edition by B. Alberts et al., Garland Publishing, 1994). In some embodiments, the poly(A) sequence is positioned 3′ to the nucleic acid sequence encoding the C-terminus of the hair cell target protein. In some embodiments, the poly(A) sequence is positioned 3′ to the nucleic acid sequence encoding the C-terminus of the supporting cell target protein or a protein of interest (e.g., a Cas9 endonuclease, e.g., a SaCas9 endonuclease (e.g., any of the SaCas9 endonucleases described herein), a reporter protein (e.g., a GFP protein, a mScarlet protein)).

As used herein, “polyadenylation” refers to the covalent linkage of a polyadenylyl moiety, or its modified variant, to a messenger RNA molecule. In eukaryotic organisms, most messenger RNA (mRNA) molecules are polyadenylated at the 3′ end. The 3′ poly(A) tail is a long sequence of adenine nucleotides (e.g., 50, 60, 70, 100, 200, 500, 1000, 2000, 3000, 4000, or 5000) added to the pre-mRNA through the action of an enzyme, polyadenylate polymerase. In higher eukaryotes, the poly(A) tail is added onto transcripts that contain a specific sequence, the polyadenylation signal or “poly(A) sequence.” The poly(A) tail and the protein bound to it aid in protecting mRNA from degradation by exonucleases. Polyadenylation is also important for transcription termination, export of the mRNA from the nucleus, and translation. Polyadenylation occurs in the nucleus immediately after transcription of DNA into RNA, but additionally can also occur later in the cytoplasm. After transcription has been terminated, the mRNA chain is cleaved through the action of an endonuclease complex associated with RNA polymerase. The cleavage site is usually characterized by the presence of the base sequence AAUAAA near the cleavage site. After the mRNA has been cleaved, adenosine residues are added to the free 3′ end at the cleavage site.

As used herein, a “poly(A) sequence” is a sequence that triggers the endonuclease cleavage of an mRNA and the additional of a series of adenosines to the 3′ end of the cleaved mRNA.

There are several poly(A) sequences that can be used, including those derived from bovine growth hormone (bgh) (Woychik et al., Proc. Natl. Acad. Sci. U.S.A. 81(13):3944-3948, 1984; U.S. Pat. No. 5,122,458), mouse-β-globin, mouse-α-globin (Orkin et al., EMBO J. 4(2):453-456, 1985; Them et al., Blood 71(2):313-319, 1988), human collagen, polyoma virus (Batt et al., Mol. Cell Biol. 15(9):4783-4790, 1995), the Herpes simplex virus thymidine kinase gene (HSV TK), IgG heavy-chain gene polyadenylation signal (US 2006/0040354), human growth hormone (hGH) (Szymanski et al., Mol. Therapy 15(7):1340-1347, 2007), the group of SV40 poly(A) sites, such as the SV40 late and early poly(A) site (Schek et al., Mol. Cell Biol. 12(12):5386-5393, 1992).

The poly(A) sequence can be a sequence of AATAAA. The AATAAA sequence may be substituted with other hexanucleotide sequences with homology to AATAAA which are capable of signaling polyadenylation, including ATTAAA, AGTAAA, CATAAA, TATAAA, GATAAA, ACTAAA, AATATA, AAGAAA, AATAAT, AAAAAA, AATGAA, AATCAA, AACAAA, AATCAA, AATAAC, AATAGA, AATTAA, or AATAAG (see, e.g., WO 06/12414).

In some embodiments, the poly(A) sequence can be a synthetic polyadenylation site (see, e.g., the pCl-neo expression vector of Promega which is based on Levitt el al, Genes Dev. 3(7):1019-1025, 1989). In some embodiments, the poly(A) sequence is the polyadenylation signal of soluble neuropilin-1 (sNRP) (AAATAAAATACGAAATG, SEQ ID NO: 90) (see, e.g., WO 05/073384). Additional examples of poly(A) sequences are known in the art.

Internal Ribosome Entry Site (IRES)

In some embodiments, a vector encoding the C-terminus of the hair cell target protein or a hair cell target protein can include a polynucleotide internal ribosome entry site (IRES). In some embodiments, a vector encoding the C-terminus of the supporting cell target protein or a supporting cell target protein can include a polynucleotide internal ribosome entry site (IRES). An IRES sequence is used to produce more than one polypeptide from a single gene transcript. An IRES forms a complex secondary structure that allows translation initiation to occur from any position with an mRNA immediately downstream from where the IRES is located (see, e.g., Pelletier and Sonenberg, Mol. Cell. Biol. 8(3):1103-1112, 1988).

There are several IRES sequences known to those in skilled in the art, including those from, e.g., foot and mouth disease virus (FMDV), encephalomyocarditis virus (EMCV), human rhinovirus (HRV), cricket paralysis virus, human immunodeficiency virus (HIV), hepatitis A virus (HAV), hepatitis C virus (HCV), and poliovirus (PV). See e.g., Alberts, Molecular Biology of the Cell, Garland Science, 2002; and Hellen et al., Genes Dev. 15(13):1593-612, 2001.

In some embodiments, the IRES sequence that is incorporated into the vector that encodes the C-terminus of a hair cell target protein or a hair cell target protein is the foot and mouth disease virus (FMDV). In some embodiments, the IRES sequence that is incorporated into the vector that encodes the C-terminus of a supporting cell target protein or a supporting cell target protein is the foot and mouth disease virus (FMDV) 2A sequence. In some embodiments, the IRES sequence that is incorporated into the vector that encodes the C-terminal portion of a protein of interest (e.g., a Cas9 endonuclease, e.g., a SaCas9 endonuclease (e.g., any of the SaCas9 endonucleases described herein)) is the FMDV 2A sequence. The Foot and Mouth Disease Virus 2A sequence is a small peptide (approximately 18 amino acids in length) that has been shown to mediate the cleavage of polyproteins (Ryan, M D et al., EMBO 4:928-933, 1994; Mattion et al., J. Virology 70:8124-8127, 1996; Furler et al., Gene Therapy 8:864-873, 2001; and Halpin et al., Plant Journal 4:453-459, 1999). The cleavage activity of the 2A sequence has previously been demonstrated in artificial systems including plasmids and gene therapy vectors (AAV and retroviruses) (Ryan et al., EMBO 4:928-933, 1994; Mattion et al., J. Virology 70:8124-8127, 1996; Furler et al., Gene Therapy 8:864-873, 2001; and Halpin et al., Plant Journal 4:453-459, 1999; de Felipe et al., Gene Therapy 6:198-208, 1999; de Felipe et al., Human Gene Therapy 11:1921-1931, 2000; and Klump et al., Gene Therapy 8:811-817, 2001).

Reporter Sequences/Detectable Marker Genes

Any of the vectors provided herein can optionally include a sequence encoding a reporter protein or a detectable marker (“a reporter sequence” or “detectable marker gene”). Non-limiting examples of reporter sequences or detectable marker genes include DNA sequences encoding: a beta-lactamase, a beta-galactosidase (LacZ), an alkaline phosphatase, a thymidine kinase, a green fluorescent protein (GFP), a red fluorescent protein, an mCherry fluorescent protein, a yellow fluorescent protein, a chloramphenicol acetyltransferase (CAT), and a luciferase. Additional examples of reporter sequences and detectable marker genes are known in the art. When associated with regulatory elements which drive their expression, the reporter sequence or detectable marker gene can provide signals detectable by conventional means, including enzymatic, radiographic, colorimetric, fluorescence, or other spectrographic assays; fluorescent activating cell sorting (FACS) assays; immunological assays (e.g., enzyme linked immunosorbent assay (ELISA), radioimmunoassay (RIA), and immunohistochemistry).

In some embodiments, the reporter sequence or detectable marker gene is the LacZ gene, and the presence of a vector carrying the LacZ gene in a primate cell (e.g., a supporting cochlear outer hair cell or a hair cell (e.g., a cochlear outer hair cell or a cochlear inner hair cell)) is detected by assays for beta-galactosidase activity. In other embodiments, the reporter or detectable marker is a fluorescent protein (e.g., green fluorescent protein) or luciferase, the presence of a vector carrying the fluorescent protein or luciferase in a primate cell (e.g., a supporting cochlear outer hair cell or a hair cell (e.g., a cochlear outer hair cell, a cochlear inner hair cell)) may be measured by fluorescent techniques (e.g., fluorescent microscopy or FACS) or light production in a luminometer (e.g., a spectrophotometer or an IVIS imaging instrument). In some embodiments, the reporter sequence or detectable marker can be used to verify the tissue-specific targeting capabilities and tissue-specific promoter regulatory activity of any of the vectors described herein.

Flanking Regions Untranslated Regions (UTRs)

In some embodiments, any of the vectors described herein (e.g., any of the at least two different vectors) can include an untranslated region. In some embodiments, a vector can includes a 5′ UTR or a 3′ UTR.

Untranslated regions (UTRs) of a gene are transcribed but not translated. The 5′ UTR starts at the transcription start site and continues to the start codon but does not include the start codon. The 3′ UTR starts immediately following the stop codon and continues until the transcriptional termination signal. There is growing body of evidence about the regulatory roles played by the UTRs in terms of stability of the nucleic acid molecule and translation. The regulatory features of a UTR can be incorporated into any of the vectors, compositions, kits, or methods as described herein to enhance the stability of a supporting cell target protein or a hair cell target protein or of a protein of interest (e.g., a Cas9 endonuclease, e.g., a SaCas9 endonuclease (e.g., any of the SaCas9 endonucleases described herein), a reporter protein (e.g., a GFP protein, a mScarlet protein).

Natural 5′ UTRs include a sequence that plays a role in translation initiation. They harbor signatures like Kozak sequences, which are commonly known to be involved in the process by which the ribosome initiates translation of many genes. Kozak sequences have the consensus sequence CCR(A/G)CCAUGG, where R is a purine (A or G) three bases upstream of the start codon (AUG), which is followed by another “G”. The 5′ UTR have also been known, e.g., to form secondary structures that are involved in elongation factor binding.

For example, in some embodiments, a 5′ UTR is included in any of the vectors described herein. Non-limiting examples of 5′ UTRs including those from the following genes: albumin, serum amyloid A, Apolipoprotein A/B/E, transferrin, alpha fetoprotein, erythropoietin, and Factor VIII, can be used to enhance expression of a nucleic acid molecule, such as a mRNA.

In some embodiments, a 5′ UTR from a mRNA that is transcribed by a cell in the cochlea can be included in any of the vectors, compositions, kits, and methods described herein. 3′ UTRs are known to have stretches of adenosines and uridines embedded in them. These AU-rich signatures are particularly prevalent in genes with high rates of turnover. Based on their sequence features and functional properties, the AU-rich elements (AREs) can be separated into three classes (Chen et al., Mol. Cell. Biol. 15:5777-5788, 1995; Chen et al., Mol. Cell Biol. 15:2010-2018, 1995): Class I AREs contain several dispersed copies of an AUUUA motif within U-rich regions. For example, c-Myc and MyoD mRNAs contain class I AREs. Class II AREs possess two or more overlapping UUAUUUA(U/A) (U/A) nonamers. GM-CSF and TNF-alpha mRNAs are examples that contain class II AREs. Class III AREs are less well defined. These U-rich regions do not contain an AUUUA motif Two well-studied examples of this class are c-Jun and myogenin mRNAs.

Most proteins binding to the AREs are known to destabilize the messenger, whereas members of the ELAV family, most notably HuR, have been documented to increase the stability of mRNA. HuR binds to AREs of all the three classes. Engineering the HuR specific binding sites into the 3′ UTR of nucleic acid molecules will lead to HuR binding and thus, stabilization of the message in vivo.

In some embodiments, the introduction, removal, or modification of 3′ UTR AREs can be used to modulate the stability of an mRNA encoding a hair cell target protein. In some embodiments, the introduction, removal, or modification of 3′ UTR AREs can be used to modulate the stability of an mRNA encoding a supporting cell target protein. In other embodiments, AREs can be removed or mutated to increase the intracellular stability and thus increase translation and production of a hair cell target protein. In other embodiments, AREs can be removed or mutated to increase the intracellular stability and thus increase translation and production of a supporting cell target protein.

In other embodiments, non-UTR sequences may be incorporated into the 5′ or 3′ UTRs. In some embodiments, introns or portions of intron sequences may be incorporated into the flanking regions of the polynucleotides in any of the vectors, compositions, kits, and methods provided herein. Incorporation of intronic sequences may increase protein production as well as mRNA levels.

Primate Cells

Also provided herein is a cell (e.g., a primate cell) that includes any of the nucleic acids, vectors (e.g., at least two different vectors described herein), or compositions described herein. In some embodiments, the primate cell is a human cell (e.g., a human supporting cell or a human hair cell). In other embodiments, the primate is a non-human primate (e.g., simian cell (e.g., a monkey cell (e.g., a marmoset cell, a baboon cell, a macaque cell), or an ape cell (e.g., a gorilla cell, a gibbon cell, an orangutan cell, a chimpanzee cell). Skilled practitioners will appreciate that the nucleic acids and vectors described herein can be introduced into any primate cell (e.g., a primate supporting cell or a primate hair cell). Non-limiting examples of vectors and methods for introducing vectors into primate cells are described herein.

In some embodiments, the primate cell can be a supporting hair cell of the inner ear of a mammal. For example, a supporting cell can be Hensen's cells, Deiters' cells, inner pillar cells, outer pillar cells, Claudius cells, inner border cells, inner phalangeal cells, or cells of the stria vascularis.

In some embodiments, the primate cell is a specialized cell of the cochlea. In some embodiments, the primate cell is a hair cell. In some embodiments, the primate cell is a cochlear inner hair cell or a cochlear outer hair cell. In some embodiments, the primate cell is a cochlear inner hair cell. In some embodiments, the primate cell is a cochlear outer hair cell.

In some embodiments, the primate cell is in vitro. In some embodiments, the primate cell is present in a primate. In some embodiments, the primate cell is autologous cell obtained from a primate and cultured ex vivo.

Methods

Also provided herein are methods of treating hearing loss (e.g., non-syndromic sensorineural hearing loss or syndromic sensorineural hearing loss) in a primate identified as having a defective hair cell target gene that include: administering to the inner ear of the primate a therapeutically effective amount of any of the compositions described herein.

In some embodiments of any of these methods, the primate has been previously identified as having a defective hair cell target gene (e.g., a hair cell target gene having a mutation that results in a decrease in the expression and/or activity of a hair cell target protein encoded by the gene). Some embodiments of any of these methods further include, prior to the introducing or administering step, determining that the primate has a defective hair cell target gene. Some embodiments of any of these methods can further include detecting a mutation in a hair cell target gene in a primate. Some embodiments of any of the methods can further include identifying or diagnosing a primate as having non-syndromic sensorineural hearing loss. Some embodiments of any of the methods can further include identifying or diagnosing a primate as having syndromic sensorineural hearing loss.

Also provided herein are methods of treating hearing loss (e.g., non-syndromic sensorineural hearing loss or syndromic sensorineural hearing loss) in a primate identified as having a defective supporting cell target gene that include: administering to the inner ear of the primate a therapeutically effective amount of any of the compositions described herein.

Also provided herein are methods that include administering to an inner ear of a primate a therapeutically effective amount of any of the compositions described herein.

In some embodiments of any of these methods, the primate has been previously identified as having a defective supporting cell target gene (e.g., a supporting cell target gene having a mutation that results in a decrease in the expression and/or activity of a supporting cell target protein encoded by the gene). Some embodiments of any of these methods further include, prior to the introducing or administering step, determining that the primate has a defective supporting cell target gene. Some embodiments of any of these methods can further include detecting a mutation in a supporting cell target gene in a primate. Some embodiments of any of the methods can further include identifying or diagnosing a primate as having non-syndromic sensorineural hearing loss. Some embodiments of any of the methods can further include identifying or diagnosing a primate as having syndromic sensorineural hearing loss.

In some embodiments of any of these methods, two or more doses of any of the compositions described herein are introduced or administered into the cochlea of the primate. Some embodiments of any of these methods can include introducing or administering a first dose of the composition into the cochlea of the primate, assessing hearing function of the primate following the introducing or the administering of the first dose, and administering an additional dose of the composition into the cochlea of the primate found not to have a hearing function within a normal range (e.g., as determined using any test for hearing known in the art).

In some embodiments of any of the methods described herein, the composition can be formulated for intra-cochlear administration. In some embodiments of any of the methods described herein, the compositions described herein can be administered via intra-cochlear administration or local administration. In some embodiments of any of the methods described herein, the compositions are administered through the use of a medical device (e.g., any of the exemplary medical devices described herein).

In some embodiments, intra-cochlear administration can be performed using any of the methods described herein or known in the art. For example, a composition can be administered or introduced into the cochlea using the following surgical technique: first using visualization with a 0 degree, 2.5-mm rigid endoscope, the external auditory canal is cleared and a round knife is used to sharply delineate an approximately 5-mm tympanomeatal flap. The tympanomeatal flap is then elevated and the middle ear is entered posteriorly. The chorda tympani nerve is identified and divided, and a currette is used to remove the scutal bone, exposing the round window membrane. To enhance apical distribution of the administered or introduced composition, a surgical laser may be used to make a small 2-mm fenestration in the oval window to allow for perilymph displacement during trans-round window membrane infusion of the composition. The microinfusion device is then primed and brought into the surgical field. The device is maneuvered to the round window, and the tip is seated within the bony round window overhang to allow for penetration of the membrane by the microneedle(s). The footpedal is engaged to allow for a measured, steady infusion of the composition. The device is then withdrawn and the round window and stapes foot plate are sealed with a gelfoam patch.

In some embodiments of any of the methods described herein, the primate has or is at risk of developing non-syndromic sensorineural hearing loss. In some embodiments of any of the methods described herein, the primate has been previously identified as having a mutation in a hair cell target gene. In some embodiments of any of the methods described herein, the primate has been previously identified as having a mutation in a supporting cell target gene. In some embodiments of any of the methods described herein, the primate has any of the mutations in a hair cell target gene that are described herein or are known in the art to be associated with non-syndromic sensorineural hearing loss or syndromic sensorineural hearing loss. In some embodiments of any of the methods described herein, the primate has any of the mutations in a supporting cell target gene that are described herein or are known in the art to be associated with non-syndromic sensorineural hearing loss or syndromic sensorineural hearing loss.

In some embodiments of any of the methods described herein, the primate has been identified as being a carrier of a mutation in a hair cell target gene (e.g., via genetic testing). In some embodiments of any of the methods described herein, the primate has been identified as being a carrier of a mutation in a supporting cell target gene (e.g., via genetic testing). In some embodiments of any of the methods described herein, the primate has been identified as having a mutation in a hair cell target gene and has been diagnosed with hearing loss (e.g., non-syndromic sensorineural hearing loss or syndromic sensorineural hearing loss). In some embodiments of any of the methods described herein, the primate has been identified as having a mutation in a supporting cell target gene and has been diagnosed with hearing loss (e.g., non-syndromic sensorineural hearing loss or syndromic sensorineural hearing loss). In some embodiments of any of the methods described herein, the primate has been identified as having hearing loss (e.g., non-syndromic sensorineural hearing loss or syndromic sensorineural hearing loss).

In some embodiments, successful treatment of hearing loss (e.g., non-syndromic sensorineural hearing loss or syndromic sensorineural hearing loss) can be determined in a primate using any of the conventional functional hearing tests known in the art. Non-limiting examples of functional hearing tests are various types of audiometric assays (e.g., pure-tone testing, speech testing, test of the middle ear, auditory brainstem response, and otoacoustic emissions).

In some embodiments of these methods, the primate cell is in vitro. In some embodiments of these methods, the primate cell is originally obtained from a primate and is cultured ex vivo. In some embodiments, the primate cell has previously been determined to have a defective hair cell target gene. In some embodiments, the primate cell has previously been determined to have a defective supporting cell target gene.

Methods for introducing any of the compositions described herein into a primate cell are known in the art (e.g., via lipofection or through the use of a viral vector, e.g., any of the viral vectors described herein).

An increase in expression of an active target protein (e.g., an active supporting cell target protein (e.g., a full-length supporting cell target protein) or an active hair cell target protein (e.g., a full-length hair cell target protein) as described herein is, e.g., as compared to a control or to the level of expression of an active target protein (e.g., an active supporting cell target protein (e.g., a full-length supporting cell target protein) or an active hair cell target protein (e.g., a full-length hair cell target protein) prior to the introduction of the vector(s).

Methods of detecting expression and/or activity of a target protein (e.g., a supporting cell target protein or a hair cell target protein) are known in the art. In some embodiments, the level of expression of a hair cell target protein can be detected directly (e.g., detecting hair cell target protein or detecting hair cell target mRNA). In some embodiments, the level of expression of a supporting cell target protein can be detected directly (e.g., detecting supporting cell target protein or detecting supporting cell target mRNA). Non-limiting examples of techniques that can be used to detect expression and/or activity of a target protein (e.g., a supporting cell target protein or a hair cell target protein) directly include: real-time PCR, Western blotting, immunoprecipitation, immunohistochemistry, or immunofluorescence. In some embodiments, expression of a hair cell target protein can be detected indirectly (e.g., through functional hearing tests). In some embodiments, expression of a supporting cell target protein can be detected indirectly (e.g., through functional hearing tests).

Pharmaceutical Compositions and Kits

In some embodiments, any of the compositions described herein can further include one or more agents that promote the entry of a nucleic acid or any of the vectors described herein into a primate cell (e.g., a liposome or cationic lipid).

In some embodiments, any of the vectors described herein can be formulated using natural and/or synthetic polymers. Non-limiting examples of polymers that may be included in any of the compositions described herein can include, but are not limited to, DYNAMIC POLYCONJUGATE® (Arrowhead Research Corp., Pasadena, Calif.), formulations from Mirus Bio (Madison, Wis.) and Roche Madison (Madison, Wis.), PhaseRX polymer formulations such as, without limitation, SMARTT POLYMER TECHNOLOGY® (PhaseRX, Seattle, Wash.), DMRI/DOPE, poloxamer, VAXFECTIN® adjuvant from Vical (San Diego, Calif.), chitosan, cyclodextrin from Calando Pharmaceuticals (Pasadena, Calif.), dendrimers and poly(lactic-co-glycolic acid) (PLGA) polymers, RONDEL™ (RNAi/Oligonucleotide Nanoparticle Delivery) polymers (Arrowhead Research Corporation, Pasadena, Calif.), and pH responsive co-block polymers, such as, but not limited to, those produced by PhaseRX (Seattle, Wash.). Many of these polymers have demonstrated efficacy in delivering oligonucleotides in vivo into a primate cell (see, e.g., deFougerolles, Human Gene Ther. 19:125-132, 2008; Rozema et al., Proc. Natl. Acad. Sci. U.S.A. 104:12982-12887, 2007; Rozema et al., Proc. Natl. Acad. Sci. U.S.A. 104:12982-12887, 2007; Hu-Lieskovan et al., Cancer Res. 65:8984-8982, 2005; Heidel et al., Proc. Natl. Acad. Sci. U.S.A. 104:5715-5721, 2007).

Any of the compositions described herein can be, e.g., a pharmaceutical composition. A pharmaceutical composition can include any of the compositions described herein and one or more pharmaceutically or physiologically acceptable carriers, diluents, or excipients. Such compositions may include one or more buffers, such as neutral-buffered saline, phosphate-buffered saline, and the like; one or more carbohydrates, such as glucose, mannose, sucrose, and dextran; mannitol; one or more proteins, polypeptides, or amino acids, such as glycine; one or more antioxidants; one or more chelating agents, such as EDTA or glutathione; and/or one or more preservatives.

In some embodiments, the composition includes a pharmaceutically acceptable carrier (e.g., phosphate buffered saline, saline, or bacteriostatic water). Upon formulation, solutions will be administered in a manner compatible with the dosage formulation and in such amount as is therapeutically effective. The formulations are easily administered in a variety of dosage forms such as injectable solutions, injectable gels, drug-release capsules, and the like.

As used herein, the term “pharmaceutically acceptable carrier” includes solvents, dispersion media, coatings, antibacterial agents, antifungal agents, and the like that are compatible with pharmaceutical administration. Supplementary active compounds can also be incorporated into any of the compositions described herein.

In some embodiments, a single dose of any of the compositions described herein can include a total sum amount of the at least two different vectors of at least 1 ng, at least 2 ng, at least 4 ng, about 6 ng, about 8 ng, at least 10 ng, at least 20 ng, at least 30 ng, at least 40 ng, at least 50 ng, at least 60 ng, at least 70 ng, at least 80 ng, at least 90 ng, at least 100 ng, at least 200 ng, at least 300 ng, at least 400 ng, at least 500 ng, at least 1 μg, at least 2 μg, at least 4 μg, at least 6 μg, at least 8 μg, at least 10 μg, at least 12 μg, at least 14 μg, at least 16 μg, at least 18 μg, at least 20 μg, at least 22 μg, at least 24 μg, at least 26 μg, at least 28 μg, at least 30 μg at least 32 μg, at least 34 μg, at least 36 μg, at least 38 μg, at least 40 μg, at least 42 μg, at least 44 μg, at least 46 μg, at least 48 μg, at least 50 μg, at least 52 μg, at least 54 μg, at least 56 μg, at least 58 μg, at least 60 μg, at least 62 μg, at least 64 μg, at least 66 μg, at least 68 μg, at least 70 μg, at least 72 μg, at least 74 μg, at least 76 μg, at least 78 μg, at least 80 μg, at least 82 μg, at least 84 μg, at least 86 μg, at least 88 μg, at least 90 μg, at least 92 μg, at least 94 μg, at least 96 μg, at least 98 μg, at least 100 μg, at least 102 μg, at least 104 μg, at least 106 μg, at least 108 μg, at least 110 μg, at least 112 μg, at least 114 μg, at least 116 μg, at least 118 μg, at least 120 μg, at least 122 μg, at least 124 μg, at least 126 μg, at least 128 μg, at least 130 μg at least 132 μg, at least 134 μg, at least 136 μg, at least 138 μg, at least 140 μg, at least 142 μg, at least 144 μg, at least 146 μg, at least 148 μg, at least 150 μg, at least 152 μg, at least 154 μg, at least 156 μg, at least 158 μg, at least 160 μg, at least 162 μg, at least 164 μg, at least 166 μg, at least 168 μg, at least 170 μg, at least 172 μg, at least 174 μg, at least 176 μg, at least 178 μg, at least 180 μg, at least 182 μg, at least 184 μg, at least 186 μg, at least 188 μg, at least 190 μg, at least 192 μg, at least 194 μg, at least 196 μg, at least 198 μg, or at least 200 μg, e.g., in a buffered solution.

The compositions provided herein can be, e.g., formulated to be compatible with their intended route of administration. A non-limiting example of an intended route of administration is local administration (e.g., intra-cochlear administration). In some embodiments, the therapeutic compositions are formulated to include a lipid nanoparticle. In some embodiments, the therapeutic compositions are formulated to include a polymeric nanoparticle. In some embodiments, the therapeutic compositions are formulated to include a mini-circle DNA. In some embodiments, the therapeutic compositions are formulated to comprise a CELiD DNA. In some embodiments, the therapeutic compositions are formulated to comprise a synthetic perilymph solution. An exemplary synthetic perilymph solution includes 20-200 mM NaCl; 1-5 mM KCl; 0.1-10 mM CaCl₂; 1-10 mM glucose; 2-50 mM HEPES, having a pH of between about 6 and about 9.

Also provided are kits including any of the compositions described herein. In some embodiments, a kit can include a solid composition (e.g., a lyophilized composition including the at least two different vectors described herein) and a liquid for solubilizing the lyophilized composition. In some embodiments, a kit can include a pre-loaded syringe including any of the compositions described herein.

In some embodiments, the kit includes a vial comprising any of the compositions described herein (e.g., formulated as an aqueous composition, e.g., an aqueous pharmaceutical composition).

In some embodiments, the kits can include instructions for performing any of the methods described herein.

Devices and Surgical Methods

Provided herein are therapeutic delivery systems for treating hearing loss (e.g., non-syndromic sensorineural hearing loss or syndromic sensorineural hearing loss). In one aspect, the therapeutic delivery systems include i) a medical device capable of creating one or a plurality of incisions in a round window membrane of an inner ear of a primate in need thereof, and ii) an effective dose of a composition (e.g., any of the compositions described herein). In some embodiments, the medical device includes a plurality of micro-needles.

Also provided herein are surgical methods for treatment of hearing loss (e.g., non-syndromic sensorineural hearing loss or syndromic sensorineural hearing loss). In some embodiments, the methods include the steps of: introducing into a cochlea of a primate a first incision at a first incision point; and administering intra-cochlearly a therapeutically effective amount of any of the compositions provided herein. In some embodiments, the composition is administered to the primate at the first incision point. In some embodiments, the composition is administered to the primate into or through the first incision.

In some embodiments of any of the methods described herein, any of the compositions described herein is administered to the primate into or through the cochlea oval window membrane. In some embodiments of any of the methods described herein, any of the compositions described herein is administered to the primate into or through the cochlea round window membrane. In some embodiments of any of the methods described herein, the composition is administered using a medical device capable of creating a plurality of incisions in the round window membrane. In some embodiments, the medical device includes a plurality of micro-needles. In some embodiments, the medical device includes a plurality of micro-needles including a generally circular first aspect, where each micro-needle has a diameter of at least about 10 microns. In some embodiments, the medical device includes a base and/or a reservoir capable of holding the composition. In some embodiments, the medical device includes a plurality of hollow micro-needles individually including a lumen capable of transferring the composition. In some embodiments, the medical device includes a means for generating at least a partial vacuum.

The invention is further described in detail by reference to the following experimental examples. These examples are provided for purposes of illustration only, and are not intended to be limiting unless otherwise specified. Thus, the invention should in no way be construed as being limited to the following examples, but rather should be construed to encompass any and all variations that become evident as a result of the teaching provided herein.

Without further description, it is believed that one of ordinary skill in the art can, using the preceding description and the following illustrative examples, make and utilize the compounds of the present invention and practice the claimed methods. The following working examples specifically point out various aspects of the present invention, and are not to be construed as limiting in any way the remainder of the disclosure.

EXAMPLES
Example 1. AAV Single Vector Injection into the Inner Ear

Immunofluorescent staining was performed on cochlear tissue of a cynomolgus macaque (non-human primate) following administration of a single Anc80-GFP AAV vector directly into the inner ear through the round window.

The cochlear tissue from the treated macaque was processed for immunofluorescence analysis using Myo7a as a marker for hair cells and Iba-1 as a marker for macrophages. The middle turn is representative of the entire sensory epithelium. The data in FIGS. 1A-1C show clear GFP expression in both the hair cells and the supporting cells, including the following supporting cell subtypes: Hensen's cells (HC), Claudius cells (CC), Dieter cells (DC), inner and outer pillar cells (OPC/IPC), inner border cells, and inner phalangeal cells (IPHC/IBC). These data demonstrate successful Anc80-GFP AAV vector transduction into different cell types of the inner ear sensory epithelium, and the resulting expression of the encoded reporter gene (GFP) in these different cell types. These data indicate the present claimed compositions including a single AAV vector or two or more AAV vectors can be used to express a gene in hair cells and supporting cells, and can be used to repair a mutation in a gene in hair cells and supporting cells.

OTHER EMBODIMENTS

It is to be understood that while the invention has been described in conjunction with the detailed description thereof, the foregoing description is intended to illustrate and not limit the scope of the invention, which is defined by the scope of the appended claims. Other aspects, advantages, and modifications are within the scope of the following claims.

All publications, patent applications, patents, and other references mentioned herein are incorporated by reference in their entirety. In case of conflict, the present specification, including definitions, will control. In addition, section headings, the materials, methods, and examples are illustrative only and not intended to be limiting.

	Number	Date	Country
	62888093	Aug 2019	US
	62756953	Nov 2018	US

	Number	Date	Country
Parent	17291931	May 2021	US
Child	18806641		US

USE OF ADENO-ASSOCIATED VIRAL VECTORS TO CORRECT GENE DEFECTS/ EXPRESS PROTEINS IN HAIR CELLS AND SUPPORTING CELLS IN THE INNER EAR

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