Claims
- 1. A composition comprising a selected viral antigen adsorbed to a poly(α-hydroxy acid) microparticle and a pharmaceutically acceptable excipient.
- 2. The composition of claim 1, wherein the microparticle is formed from a poly(α-hydroxy acid) selected from the group consisting of poly(L-lactide), poly(D,L-lactide) and poly(D,L-lactide-co-glycolide).
- 3. The composition of claim 2, wherein the microparticle is formed from poly(D,L-lactide-co-glycolide.
- 4. The composition of claim 1, wherein the selected antigen is gp120.
- 5. The composition of claim 1, wherein the selected antigen is p24gag.
- 6. The composition of claim 1, wherein the selected antigen is Influenza A hemagglutinin antigen.
- 7. A method of immunization which comprises administering to a vertebrate subject a therapeutically effective amount of a selected viral antigen adsorbed to a poly(α-hydroxy acid) microparticle.
- 8. The method of claim 7, wherein the microparticle is formed from a poly(α-hydroxy acid) selected from the group consisting of poly(L-lactide), poly(D,L-lactide) and poly(D,L-lactide-co-glycolide).
- 9. The method of claim 8, wherein the microparticle is formed from poly(D,L-lactide-co-glycolide.
- 10. The method of claim 7, wherein the selected antigen is gp120.
- 11. The method of claim 7, wherein the selected antigen is p24gag.
- 12. The method of claim 7, wherein the selected antigen is Influenza A hemagglutinin antigen.
- 13. The method of claim 7, further comprising administering a submicron oil-in-water emulsion to said subject.
- 14. A method for eliciting a cellular immune response in a vertebrate subject comprising administering to a vertebrate subject a therapeutically effective amount of a selected viral antigen adsorbed to a poly(α-hydroxy acid) microparticle.
- 15. The method of claim 14, wherein the microparticle is formed from a poly(α-hydroxy acid) selected from the group consisting of poly(L-lactide), poly(D,L-lactide) and poly(D,L-lactide-co-glycolide).
- 16. The method of claim 15, wherein the microparticle is formed from poly(D,L-lactide-co-glycolide.
- 17. The method of claim 14, wherein the selected antigen is gp120.
- 18. The method of claim 14, wherein the selected antigen is p24gag.
- 19. The method of claim 14, wherein the selected antigen is Influenza A hemagglutinin antigen.
- 20. A method of producing a composition comprising:
(a) providing a viral antigen; (b) adsorbing said viral antigen to a poly(α-hydroxy acid) microparticle; and (c) combining said microparticle with the adsorbed antigen with a pharmaceutically acceptable excipient.
- 21. The method of claim 20, wherein the microparticle is formed from a poly(α-hydroxy acid) selected from the group consisting of poly(L-lactide), poly(D,L-lactide) and poly(D,L-lactide-co-glycolide).
- 22. The method of claim 21, wherein the microparticle is formed from poly(D,L-lactide-co-glycolide.
- 23. The method of claim 20, wherein the selected antigen is gp120.
- 24. The method of claim 20, wherein the selected antigen is p24gag.
- 25. The method of claim 20, wherein the selected antigen is Influenza A hemagglutinin antigen.
CROSS-REFERENCE TO RELATED APPLICATIONS
[0001] This application is related to provisional patent applications serial Nos. 60/036,316, filed Jan. 30, 1997 and 60/069,749, filed Dec. 16, 1997, from which priority is claimed under 35 USC §119(e)(1) and which applications are incorporated herein by reference in their entireties.
Provisional Applications (2)
|
Number |
Date |
Country |
|
60036316 |
Jan 1997 |
US |
|
60069749 |
Dec 1997 |
US |
Continuations (1)
|
Number |
Date |
Country |
Parent |
09015652 |
Jan 1998 |
US |
Child |
10189104 |
Jul 2002 |
US |