The present invention relates to an X-ray device using X-ray and an X-ray measurement method.
Non-destructive examination using radiation is used in a wide range of fields from an industrial use to a medical use. For example, an X-ray, which is one of radial rays, is an electromagnetic wave with a wavelength of about 10−12 to 10−8 m and an X-ray with high energy (about 2 keV to 100 keV) is called a hard X-ray. An X-ray with low energy (about 0.1 keV to 2 keV) is called a soft X-ray.
An absorption contrast method that uses difference of X-ray absorption ability is practically used in a security field such as internal crack inspection of steel material and baggage inspection.
On the other hand, an X-ray phase contrast method that detects phase change of X-ray by an object is effective for an object where contrast is difficult to be generated by absorption of X-ray (for example, a low density object). A method that uses such X-ray phase contrast imaging is studied to be applied to imaging of a phase separation structure of high polymer material, medical procedure, and the like.
PTL 1 discloses an X-ray imaging device in which a mask that blocks X-rays is placed on an edge portion of pixels of a detector.
In
However, the method described in PTL 1 cannot separately extract the information of the X-ray absorbed by the object and information of the X-ray scattered by the object from acquired data. When the object is formed of an aggregate of microparticles or the like, the X-ray 1303 is spread by the effect of scattering and the detection pixel 1301 detects change of intensity of the X-ray caused by the scattering of the X-ray. However, the absorption of the X-ray by the object also generates the change of intensity. Therefore, the method described in PTL 1 cannot determine whether the change of intensity is caused by the absorption of the object or the scattering of the X-ray.
PTL 1 International Publication No. 2008/029107 pamphlet
Therefore, the present invention provides an X-ray device and an X-ray measurement method which can acquire the information of the scattering of the X-ray separate from the information of the absorption of the X-ray.
The X-ray device includes a detector including a first pixel and a second pixel different from the first pixel, which are configured to detect intensity of an X-ray beam passing through an object, an attenuation element configured to attenuate an X-ray beam which is a part of the X-ray beam passing through the object and incident on the second pixel, and an arithmetic device configured to acquire information of the object including scattering information of the object from detection intensity of the X-ray beam detected by the first pixel and detection intensity of the X-ray beam detected by the second pixel. When the object is not located in an optical path of the X-ray beam, the X-ray beam is irradiated on a boundary between the first pixel and the second pixel.
Other aspects of the present invention will be described in embodiments.
In embodiments of the present invention, a detection result, by which object information including information of phase change and information of scattering of X-ray caused by the object can be acquired, is obtained by using an X-ray beam and a detector. The information of phase change of X-ray caused by the object is referred to as phase information of the object and the information of scattering of X-ray caused by the object is referred to as scattering information of the object. An X-ray device of the embodiments further includes an arithmetic device and can acquire information of the object including the phase information of the object and the scattering information of the object from the detection result of the detector. The information of the object including the phase information of the object and the scattering information of the object may be referred to as simply the scattering information of the object.
When the object is not located in an optical path of the X-ray beam, the X-ray beam can be detected by both first and second pixels. The X-ray irradiated to the second pixel is irradiated to the second pixel after passing through an attenuation element. As the attenuation element, an attenuation element is arranged which changes the intensity of the X-ray according to the amount of change of an irradiation position of the X-ray irradiated to the second pixel. The arithmetic device acquires the information of the object including both the phase information and the scattering information from intensity information of the first pixel and the second pixel. When the information is imaged, an image including the phase information and the scattering information can be acquired. The arithmetic device is configured to be able to acquire absorption contrast. Hereinafter, specific embodiments will be described.
In a first embodiment, an X-ray device and an X-ray measurement method which use one X-ray beam will be described.
An X-ray generated from an X-ray source 101, which is an X-ray generation unit, is formed into an X-ray beam by an aperture 103.
As the aperture 103, for example, an aperture having a slit shape that can form a line-shaped X-ray beam or having a pin hole shape that can form a point-shaped X-ray beam. The slit and the pin hole may penetrate a substrate or need not penetrate the substrate. When the slit and the pin hole do not penetrate the substrate, a filter material for X-ray may be used as a substrate of a splitting element. A material that forms the aperture 103 is selected from Pt, Au, Pb, Ta, W, and the like which have a high absorption rate of X-ray. Or, the material may be a compound including these materials.
The X-ray beam passing through the object 104 is irradiated to an attenuation element 105 and the intensity of the X-ray is detected by a detector 106. The detected intensity information is arithmetically processed by an arithmetic device 107 and outputted to a display unit 108 such as a monitor.
Examples of the object 104 include an inorganic material and an inorganic-organic composite material in addition to a human body.
Moving units 109, 110, 111, and 112 such as stepping motors which relatively move the aperture 103, the object 104, the attenuation element 105, and the detector 106 may be provided. For example, if measurement is performed while the object 104 is being moved by the moving unit 110, the entire image of the object 104 can be obtained.
As the detector 106, various two-dimensional X-ray detectors can be used whether the X-ray detector is an indirect conversion type or a direct conversion type. For example, the detector 106 is selected from an X-ray CCD camera, an indirect conversion type flat panel detector, a direct conversion type flat panel detector, and the like. Also, a discrete type photodiode may be used.
When a monochromatic X-ray is used, a monochromatizing unit 102 may be disposed between the X-ray source 101 and the aperture 103. As the monochromatizing unit 102, a monochromator or an X-ray multilayer mirror combined with a slit may be used.
Next, a relationship between the X-ray beam, the attenuation element, and the detector according to the present embodiment will be described with reference to
An X-ray beam 301 represents an X-ray beam when the object 104 is not located in the optical path of the X-ray beam. The X-ray beam 301 is irradiated to a first pixel 303 and a second pixel 304. An attenuation element 302 is arranged on the second pixel 304. When the object 104 is not located in an optical path of the X-ray beam 301, the center of the intensity of the X-ray beam 301 (the center of gravity of the X-ray beam) is set to be located on a boundary between the first pixel 303 and the second pixel 304.
Although the first pixel 303 and the second pixel 304 are arranged adjacent to each other in
The attenuation element 302 is formed into a wedge shape (triangular prism) and has an absorption ability slope where the amount of absorption (the amount of transmission) of X-ray varies along a direction in which the irradiation position is changed by the refraction of the X-ray beam caused by the object. Here, the attenuation element 302 is formed so that the farther away from the boundary between the first pixel 303 and the second pixel 304 in the direction toward the second pixel, the larger the amount of absorption of X-ray.
The absorption ability slope of the attenuation element 302 need not necessarily be continuous, but the amount of absorption (the amount of transmission) may change in a staircase pattern (in a step shape). For example, the shape of the absorption ability slope may change in incremental steps. In the present description, the step shape is also represented as “continuous”. However, it is preferable that there are two or more steps (there are a region a1, a region a2, and a region a3 of the absorption ability). Not only the attenuation element 302 in which the thickness of the element continuously changes, but also the attenuation element 302 in which the density of the element continuously changes may be used.
The X-ray beam that enters the second pixel 304 enters the second pixel 304 after passing through the attenuation element 302. The second pixel 304 and the attenuation element are arranged such that the X-ray beam enters the second pixel 304 after passing through the attenuation element 302. In the description of the present application, the arrangement described above is referred to as “the attenuation element is arranged on the second pixel”.
To arrange the attenuation element on the second pixel, for example, the attenuation element may be arranged on the upper side of the second pixel. Here, the upstream side of the X-ray (the side of the X-ray source) is defined as the upper side.
In
When the incident position of the X-ray beam 301 changes, the detection intensities of the first pixel 303 and the second pixel 304 also change. Here, the attenuation element 302 is not arranged on the first pixel 303, but the attenuation element 302 is arranged on the second pixel 304, so that the amount of change of the detection intensity with respect to the position change of the X-ray beam is different between the first pixel 303 and the second pixel 304. Therefore, the amount of position change of the X-ray beam can be estimated on the basis of an index that can determine a difference between the amount of change of the detection intensity of the first pixel 303 and the amount of change of the detection intensity of the second pixel 304.
For example, when the intensity of the first pixel 303 is I1 and the intensity of the second pixel 304 is I2, it is possible to estimate the amount of position change of the center of gravity of the X-ray beam by using a value v indicated in the formula (1).
Here, in order to cancel the effect of the absorption, the difference between I1 and I2 is divided by the sum of I1 and I2. Hereinafter, the position change of the center of gravity of the X-ray beam may be referred to as simply the position change of the X-ray beam.
In
In a region of the first pixel 303 where the attenuation element 302 is not located, the intensity profile 402 is more broadened than the intensity profile 401 by the effects of scattering. On the other hand, in a region of the second pixel 304 where the attenuation element 302 is located, although there are the effects of scattering, the sensitivity to the change of the intensity is reduced by the attenuation element 302. Therefore, in the region of the second pixel 304, the profile is less broadened than that in the region of the first pixel 303. In other words, the change of the detection intensity of the scattering is different between the area where the attenuation element 302 is located and the area where the attenuation element 302 is not located.
As understood from
A more detailed description will be given with reference to
However, the actual data is an unknown sample. Therefore, even if a value of v=v1 is obtained as an experimental result of an unknown sample, the value can be substituted into only a relational expression (plots represented by the black squares) acquired from the data obtained by not locating the object. Therefore, if Δx is obtained by using the plots (black squares) of the data obtained by not locating the object, when v is v1, Δx is Δx1.
In other words, although a true amount of position change (Δx) of the X-ray beam passing through a certain region is 0, when the amount of position change of the X-ray is acquired by using the data obtained by not locating the object, Δx is Δx1. When the amount of position change is converted into an image, due to a difference between a true amount of position change (here, 0) and an acquired amount of position change (here, Δx1), a contrast is formed between a region including scattering and a region not including scattering even when the amount of refraction of the X-ray beam is the same.
The above phenomenon will be described from another point of view with reference to
Although the value of v may be directly outputted as the contrast of the images, in this case, if the position of the X-ray beam changes, the contrast is distorted because the relationship between v and Δx is nonlinear. Therefore, the arithmetic device 107 fits the relationship between v and Δx by a function in advance. The arithmetic device 107 calculates v from the detection intensities of each pixel detected by the detector 106 and further obtains Δx by substituting v into the fitted function. It is possible to reduce the distortion of the contrast by converting the Δx into an image.
In the embodiment described above, the pixel value of the output image is given from v which is an index obtained by the formula (1). However, the important point is that indexes other than v can be used if the indexes can determine the difference between the amount of change of the detection intensity of the first pixel and the amount of change of the detection intensity of the second pixel, which are caused by refraction or scattering.
In other words, any index can be used which is based on a difference, a ratio, or the like between the detection intensity of the first pixel and the detection intensity of the second pixel.
For example, the formula (1) divides the difference between I1 and I2 by the sum of I1 and I2. This is based on the difference between the detection intensity of the first pixel and the detection intensity of the second pixel. For example an index may be used in which “(I1−I2)2” is used instead of (I1−I2) in the formula (1) described above.
Similarly, the index may be an index which is based on a ratio between the detection intensity of the first pixel and the detection intensity of the second pixel. For example, the pixel value of the output image may be determined by using v′ represented by the formula (2) below.
In the same manner as in
Although, in the same manner as in the case of v, v′ may be used as the pixel value of the output image, in such a case, the contrast is distorted because the relationship between v′ and Δx is nonlinear. Therefore, the relationship between v′ and Δx is fitted by a function. Then, v′ is calculated from the detection intensities of each pixel detected by the detector 106 and further Δx is obtained by substituting v′ into the fitted function. It is possible to reduce the distortion of the contrast by using the Δx as the pixel value.
The amount of position change of the X-ray beam caused by the object 104 where the phase change is small is slight, so that the nonlinear effect is small. Therefore, the value of v or v′ may be directly converted into an image.
In the above description, Δx is determined by using v, v′, or the like calculated from a measurement value when the object is located in the optical path of the X-ray beam. However, the pixel value may be determined by using an index or the like obtained by subtracting v when the object is not located from v when the object is located. Specifically, the pixel value may be determined on the basis of H of the formula (3) below.
H=(I1−I2)/(I1+I2)−(I1(0)−I2(0))/(I1(0)+I2(0)) Formula (3)
Here, I1(0) is the detection intensity of the first pixel when the object is not located. I2(0) is the detection intensity of the second pixel when the object is not located. The index H of the above formula (3) is also an index which is based on the difference between the detection intensity of the first pixel and the detection intensity of the second pixel.
Instead of creating a function, it is possible to obtain Δx by, for example, converting the relationship between v and Δx into a database and performing interpolation by using data of the database on the basis of v obtained by measurement.
When acquiring an absorption contrast image of the object, it is possible to acquire the absorption contrast image by calculating the sum of I1 and I2 and using the sum as the pixel value of the output image. An average value obtained by dividing the sum of I1 and I2 by 2 may be used as the pixel value of the output image. The above calculation methods and other calculation methods related to the sum may be referred to as “on the basis of the sum”. Or, data of only I1 may be used as the pixel value of the output image. Although the center of gravity of the X-ray is located on the boundary between the first pixel and the second pixel in the first embodiment, the center of gravity of the X-ray may be located on other than the boundary between the first pixel and the second pixel if the change of the detection intensity with respect to the change of the intensity of the X-ray incident on the detector is different between the first pixel and the second pixel.
In the present embodiment, an example will be described in which an element that blocks X-ray is used as the attenuation element. Although a device configuration is the same as the configuration described in
An X-ray beam 701 is an X-ray beam when an object is not located in the optical path of the X-ray beam. The X-ray beam 701 is irradiated to a first pixel 703 and a second pixel 704. An attenuation element 702 is arranged on the second pixel 704. Here, the center of gravity of the X-ray beam 701 is set to be located on a boundary between the first pixel 703 and the second pixel 704. The attenuation element 702 is arranged on a position different from the boundary between the first pixel 703 and the second pixel 704 and a part of the X-ray beam 701 is blocked. In
The attenuation element 702 has a function to block the incident X-ray. Therefore, the attenuation element 702 is selected from materials such as Au and W which have a high X-ray absorption ability. The attenuation element 702 need not necessarily have a plate shape as long as the attenuation element 702 has a function to block the X-ray. The attenuation element 702 need not necessarily block all the X-ray, but may block the X-ray at a level at which an image can be acquired. For example, the attenuation element 702 may have a blocking rate of 90% or more.
The change rate of the detection intensity with respect to the position change of the X-ray beam is different between the first pixel 703 and the second pixel 704 due to the attenuation element 702. Therefore, in the same manner as in the first embodiment, it is possible to acquire the scattering information by calculating v, v′, H, or the like by the arithmetic device 107.
As shown in
In the present embodiment, a configuration example of an X-ray device in which a plurality of X-ray beams are generated by using a splitting element will be described.
The slits and the pin holes may penetrate a substrate of the splitting element or need not penetrate the substrate. When the slits and the pin holes do not penetrate the substrate, a filter material for X-ray may be used as the substrate of the splitting element. A material that forms the splitting element 903 is selected from Pt, Au, Pb, Ta, W, and the like which have a high absorption rate of X-ray. Or, the material may be a compound including these materials.
The phases of X-ray beams spatially divided by the splitting element 903 are changed by an object 904 and the X-ray beams are refracted. The X-ray is absorbed by the object 904. The intensity profile of the X-ray beam becomes broad due to the effects of the scattering of the X-ray caused by the object 904.
The X-ray beams passing through the object 904 are irradiated to an attenuation element 905 and the intensities of the X-rays are detected by a detector 906. Information related to the X-rays obtained by the detector 906 is arithmetically processed by an arithmetic device 907 and outputted to a display unit 908 such as a monitor.
Moving units 909, 910, 911, 912, and 913 such as stepping motors which relatively move the splitting element 903, the object 904, the attenuation element 905, the detector 906, and the X-ray source 901 may be provided. For example, if the moving unit 910 is provided, the object 904 can be arbitrarily moved, so that an image of a specific portion of the object 904 can be obtained. It is possible to obtain all information of the object 904 by measuring the object 904 while scanning the object with respect to the X-rays, so that high spatial resolution of the output image can be achieved.
It is possible to acquire a CT image by detecting X-ray intensities while rotating the X-ray source 901, the splitting element 903, the attenuation element 905, and the detector 906 in synchronization with each other around the object 904 by using the moving units 909, 911, 912, and 913.
The detector 906 and a monochromatizing unit 902 may be the same as those in the first embodiment.
Next, a relationship between the X-ray beams, the attenuation element 905, and the detector 906 according to the present embodiment will be described with reference to
For example, the attenuation elements 1004 are arranged every two pixels to be discretely irradiated by considering the pitch of the openings in the splitting element 903, the pixel size of the detector 906, the distance relationships between the X-ray source 901, the splitting element 903, and the detector 906. In
For example, when the object 904 is not located in the optical path, the center of gravity of the X-ray beam 1001 on the detector 906 is located on a boundary position between two pixels irradiated with the X-ray beam 1001.
In the same manner as in the above embodiment, it is possible to acquire an image in which the scattering information is superimposed on the phase information by using an arithmetic device 1007 for a plurality of X-ray beams.
In the present example, an example will be described in which a slit array is used as the splitting element.
The device configuration is the same as that shown in
An attenuation element 1102 in
As the detector 906, an indirect conversion type flat panel detector having a pixel size of 100 μm×100 μm is used.
The splitting element 903 and the attenuation element 905 are moved by using the moving units 909 and 911 to be arranged so that each X-ray beam is projected every two pixels (every 200 μm). The center of gravity of an X-ray beam 1103 is located at the tip portion of the slope portion of the attenuation element 1102. The center of gravity of each X-ray beam is located at a boundary between two pixels irradiated with each X-ray beam.
In this state, v represented by the formula (1) with respect to the amount of position change (Δx) is obtained by measuring the detection intensities of the first pixel and the second pixel of each X-ray beam in the detector 905 while moving the detection element 903. A function to obtain Δx from v can be obtained by fitting the Δx and v by a quartic function.
As the object 904, water and flour, each of which is contained in a plastic container, are used.
The v represented by the formula (1) is calculated by the arithmetic device 907 from intensity data of the first pixel and the second pixel with respect to each X-ray beam and the Δx is obtained by using a quartic function obtained in advance.
An image including the phase information and the scattering information is acquired by arranging Δx of each X-ray beam as values of pixels and the image is outputted to a PC monitor which is a display unit 1107.
As a result of imaging, a difference of contrast is hardly observed between the water and the flour in an image of the absorption contrast. However, a large contrast is obtained in the flour where the scattering is large in the image including the phase information and the scattering information, so that a difference between the water and the flour can be observed.
While the present invention has been described with reference to exemplary embodiments, it is to be understood that the invention is not limited to the disclosed exemplary embodiments. The scope of the following claims is to be accorded the broadest interpretation so as to encompass all such modifications and equivalent structures and functions.
This application claims the benefit of Japanese Patent Application No. 2012-130103, filed Jun. 7, 2012, which is hereby incorporated by reference herein in its entirety.
Number | Date | Country | Kind |
---|---|---|---|
2012-130103 | Jun 2012 | JP | national |
Filing Document | Filing Date | Country | Kind |
---|---|---|---|
PCT/JP2013/064566 | 5/21/2013 | WO | 00 |