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Patents Grants
last 30 patents
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Patent Grant
Lipidic analogs of anti-cancer stem cell agent
Patent number
12,358,941
Issue date
Jul 15, 2025
Virginia Commonwealth University
Umesh R. Desai
A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information
Patent Grant
Polymer agents for cardiopulmonary resuscitation
Patent number
12,350,289
Issue date
Jul 8, 2025
Virginia Commonwealth University
Martin J. Mangino
A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information
Patent Grant
Compositions and methods for restoring or increasing tissue perfusion
Patent number
12,337,012
Issue date
Jun 24, 2025
Virginia Commonwealth University
Martin J. Mangino
A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information
Patent Grant
Metallic and magnetic carbon material
Patent number
12,325,635
Issue date
Jun 10, 2025
Virginia Commonwealth University
Puru Jena
C23 - COATING METALLIC MATERIAL COATING MATERIAL WITH METALLIC MATERIAL CHEMI...
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Patent Grant
MDA-7/IL-24 secretory variants and methods of use
Patent number
12,325,863
Issue date
Jun 10, 2025
Virginia Commonwealth University
Paul B. Fisher
A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
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Patent Grant
Fabrication of aerogels and aerogel composites by ambient pressure...
Patent number
12,291,621
Issue date
May 6, 2025
Virginia Commonwealth University
Massimo Bertino
C08 - ORGANIC MACROMOLECULAR COMPOUNDS THEIR PREPARATION OR CHEMICAL WORKING-...
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Patent Grant
Biofouling-resistant nanoporous alloys
Patent number
12,272,494
Issue date
Apr 8, 2025
Virginia Commonwealth University
Ahmed A. Farghaly
C22 - METALLURGY FERROUS OR NON-FERROUS ALLOYS TREATMENT OF ALLOYS OR NON-FER...
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Patent Grant
Chimeric vaccine antigens for anaplasmosis
Patent number
12,239,696
Issue date
Mar 4, 2025
Virginia Commonwealth University
Richard T. Marconi
C07 - ORGANIC CHEMISTRY
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Patent Grant
Compositions comprising 5-cholesten-3, 25-diol, 3-sulfate (25HC3S)...
Patent number
12,226,423
Issue date
Feb 18, 2025
Virginia Commonwealth University
Shunlin Ren
A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information
Patent Grant
Compounds as NLRP3 inflammasome inhibitors and compositions and use...
Patent number
12,221,406
Issue date
Feb 11, 2025
Virginia Commonwealth University
Shijun Zhang
C07 - ORGANIC CHEMISTRY
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Patent Grant
Subwavelength antennas, drivers, and systems
Patent number
12,217,890
Issue date
Feb 4, 2025
Virginia Commonwealth University
Supriyo Bandyopadhyay
B82 - NANO-TECHNOLOGY
Information
Patent Grant
3D printed magnetocaloric devices with controlled microchannels and...
Patent number
12,179,266
Issue date
Dec 31, 2024
Virginia Commonwealth University
Hong Zhao
B22 - CASTING POWDER METALLURGY
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Patent Grant
Electrospun dextran fibers and devices formed therefrom
Patent number
12,171,888
Issue date
Dec 24, 2024
Virginia Commonwealth University
Gary Bowlin
Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC
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Patent Grant
Devices and methods for repairing damage to a tissue
Patent number
12,161,862
Issue date
Dec 10, 2024
BIOCIRCUIT TECHNOLOGIES, INC.
Jonathan Isaacs
A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information
Patent Grant
Polymeric aerogel composite and synthesis by ambient and freeze-drying
Patent number
12,077,642
Issue date
Sep 3, 2024
Virginia Commonwealth University
Massimo Bertino
C08 - ORGANIC MACROMOLECULAR COMPOUNDS THEIR PREPARATION OR CHEMICAL WORKING-...
Information
Patent Grant
High-yielding continuous flow synthesis of antimalarial drug hydrox...
Patent number
12,071,410
Issue date
Aug 27, 2024
Virginia Commonwealth University
Frank B. Gupton
B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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Patent Grant
Benzaldehyde compounds with direct polymer destabilizing effects to...
Patent number
12,065,408
Issue date
Aug 20, 2024
Virginia Commonwealth Univeristy
Martin Safo
A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information
Patent Grant
Low temperature formation of perovskite films in supercritical fluids
Patent number
12,006,574
Issue date
Jun 11, 2024
Virginia Commonwealth University
Gary Tepper
C23 - COATING METALLIC MATERIAL COATING MATERIAL WITH METALLIC MATERIAL CHEMI...
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Patent Grant
Microdevice for differential separation, purification and amplifica...
Patent number
11,986,822
Issue date
May 21, 2024
Virginia Commonwealth University
Tracey Dawson Green
B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
Information
Patent Grant
Stent retriever cleaning devices and methods
Patent number
11,986,361
Issue date
May 21, 2024
Virginia Commonwealth University
Dennis J. Rivet
B08 - CLEANING
Information
Patent Grant
Devices and methods for repairing damage to a tissue
Patent number
11,918,801
Issue date
Mar 5, 2024
BIOCIRCUIT TECHNOLOGIES, INC.
Jonathan Isaacs
A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information
Patent Grant
Chimeric recombinant proteins and recombinant protein panels for th...
Patent number
11,899,015
Issue date
Feb 13, 2024
Virginia Commonwealth University
Richard Marconi
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Grant
Inhibitors of cancer invasion, attachment, and/or metastasis
Patent number
11,891,399
Issue date
Feb 6, 2024
Virginia Commonwealth University
Paul B. Fisher
A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information
Patent Grant
Pilocarpine ionic liquids for treatment of glaucoma
Patent number
11,845,741
Issue date
Dec 19, 2023
Virginia Commonwealth University Intellectual Property Foundation
Juan Wang
A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information
Patent Grant
Nitric oxide-releasing 3D-printing compositions and uses thereof
Patent number
11,814,519
Issue date
Nov 14, 2023
Virginia Commonwealth University
Xuewei Wang
B29 - WORKING OF PLASTICS WORKING OF SUBSTANCES IN A PLASTIC STATE, IN GENERAL
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Patent Grant
Carbohydrate-functionalized nanoparticles and uses thereof
Patent number
11,801,309
Issue date
Oct 31, 2023
Virginia Commonwealth University Intellectual Property Foundation
Hu Yang
A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information
Patent Grant
Anti-IGFBP-3R antibodies and methods of treating an IGFBP-3R expres...
Patent number
11,786,585
Issue date
Oct 17, 2023
Virginia Commonwealth University
Youngman Oh
A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information
Patent Grant
Sphingosine kinase Type 1 inhibitors and uses thereof
Patent number
11,737,992
Issue date
Aug 29, 2023
Enzo Therapeutics, Inc.
Sarah Spiegel
A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information
Patent Grant
Devices, systems, and methods for dry powder therapies
Patent number
11,690,964
Issue date
Jul 4, 2023
Virginia Commonwealth University
Philip Worth Longest
A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information
Patent Grant
Preparation of recombinant tetrameric N-acetylated alpha-synuclein
Patent number
11,673,913
Issue date
Jun 13, 2023
Virginia Commonwealth University
Heather R. Lucas
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
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Patents Applications
last 30 patents
Information
Patent Application
SUBWAVELENGTH ANTENNAS, DRIVERS, AND SYSTEMS
Publication number
20250239390
Publication date
Jul 24, 2025
Virginia Commonwealth University
Supriyo BANDYOPADHYAY
B82 - NANO-TECHNOLOGY
Information
Patent Application
METHODS AND SYSTEMS FOR SURGICAL TRAINING
Publication number
20250239177
Publication date
Jul 24, 2025
Virginia Commonwealth University
Lauren Siff
G09 - EDUCATION CRYPTOGRAPHY DISPLAY ADVERTISING SEALS
Information
Patent Application
METHODS FOR DETECTING INDOLE, AN INDOLE PRODUCING BACTERIUM, OR AN...
Publication number
20250231179
Publication date
Jul 17, 2025
The Regents of the University of Michigan
Xuewei Wang
G01 - MEASURING TESTING
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Patent Application
NALTREXAMINE DERIVATIVES BEARING 5-MEMBER HETEROCYCLIC RING SYSTEMS...
Publication number
20250195504
Publication date
Jun 19, 2025
Virginia Commonwealth University
Yan ZHANG
A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information
Patent Application
PREPARATION OF GAMMA-GLUTAMYLCYSTEINE, A PRECURSOR OF GLUTATHIONE
Publication number
20250162987
Publication date
May 22, 2025
Children's National Medical Center
Frank GUPTON
C07 - ORGANIC CHEMISTRY
Information
Patent Application
DIGITAL MODULATED RADIOGRAPHY
Publication number
20250152972
Publication date
May 15, 2025
Virginia Commonwealth University
Siyong Kim
G06 - COMPUTING CALCULATING COUNTING
Information
Patent Application
OVERLAYS FOR SOFTWARE AND HARDWARE VERIFICATION
Publication number
20250130972
Publication date
Apr 24, 2025
Virginia Commonwealth University
Carl Elks
G06 - COMPUTING CALCULATING COUNTING
Information
Patent Application
NATIVE CELL MEMBRANE NANOPARTICLES
Publication number
20250109226
Publication date
Apr 3, 2025
VIRGINIA COMMONWEALTH UNIVERSITY
Youzhong GUO
C07 - ORGANIC CHEMISTRY
Information
Patent Application
DEVICES AND METHODS FOR REPAIRING DAMAGE TO A TISSUE
Publication number
20250065111
Publication date
Feb 27, 2025
BioCircuit Technologies, Inc.
Isaac Perry Clements
A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information
Patent Application
METALLIC CLUSTER MODIFIED NANOPORE SENSING FOR PEPTIDE DETECTION
Publication number
20250067721
Publication date
Feb 27, 2025
Virginia Commonwealth University
Joseph E. Reiner
G01 - MEASURING TESTING
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Patent Application
SUSTAINED RELEASE FORMULATIONS AND METHODS OF USE THEREOF
Publication number
20250064971
Publication date
Feb 27, 2025
Virginia Commonwealth University
Qingguo XU
A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information
Patent Application
SYSTEMS AND METHODS FOR PHOTODYNAMIC THERAPY
Publication number
20250065147
Publication date
Feb 27, 2025
Virginia Commonwealth University
Seung Duk Lee
A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information
Patent Application
MODULAR FIELD-STABLE BIO-ARTIFICIAL BLOOD SUBSTITUTE
Publication number
20250064724
Publication date
Feb 27, 2025
Virginia Commonwealth University
Martin J. MANGINO
A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information
Patent Application
METHODS FOR DECELLULARIZING ANIMAL TISSUE AND BIOINKS DERIVED THERE...
Publication number
20250034413
Publication date
Jan 30, 2025
Virginia Commonwealth University
Lucas C. OLSON
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Application
NATIVE CELL MEMBRANE NANOPARTICLES
Publication number
20250026892
Publication date
Jan 23, 2025
Virginia Commonwealth University
Youzhong GUO
G01 - MEASURING TESTING
Information
Patent Application
FIRE-RESISTANT, FIRE RETARDANT AND/OR THERMAL INSULATION
Publication number
20250019511
Publication date
Jan 16, 2025
Virginia Commonwealth University
Massimo BERTINO
C09 - DYES PAINTS POLISHES NATURAL RESINS ADHESIVES MISCELLANEOUS COMPOSITION...
Information
Patent Application
BENZALDEHYDE COMPOUNDS WITH DIRECT POLYMER DESTABILIZING EFFECTS TO...
Publication number
20250019349
Publication date
Jan 16, 2025
Virginia Commonwealth University
Martin SAFO
C07 - ORGANIC CHEMISTRY
Information
Patent Application
ANATOMICALLY ACCURATE RODENT HEAD MODELS AND BRAIN PHANTOMS AND MET...
Publication number
20250001697
Publication date
Jan 2, 2025
Virginia Commonwealth University
Chirayu NIMONKAR
G06 - COMPUTING CALCULATING COUNTING
Information
Patent Application
NEONATAL CIRCUMCISION TRAINING MODEL
Publication number
20240420594
Publication date
Dec 19, 2024
Virginia Commonwealth University
Casey Freymiller
G09 - EDUCATION CRYPTOGRAPHY DISPLAY ADVERTISING SEALS
Information
Patent Application
METHOD FOR CONNECTION TO A RIGID OR FLEXIBLE DEVICE USING MULTIFUNC...
Publication number
20240376332
Publication date
Nov 14, 2024
Virginia Commonwealth University
Vamsi YADAVALLI
C09 - DYES PAINTS POLISHES NATURAL RESINS ADHESIVES MISCELLANEOUS COMPOSITION...
Information
Patent Application
INHIBITORS OF CANCER INVASION, ATTACHMENT, AND/OR METASTASIS
Publication number
20240360138
Publication date
Oct 31, 2024
Virginia Commonwealth University
Paul B. FISHER
A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information
Patent Application
NON-VOLATILE NANOMAGNETIC MATRIX MULTIPLIER-ACCUMULATOR
Publication number
20240354522
Publication date
Oct 24, 2024
Virginia Commonwealth University
Supriyo BANDYOPADHYAY
G06 - COMPUTING CALCULATING COUNTING
Information
Patent Application
HIGH TEMPERATURE END EFFECTORS FOR ROBOTS
Publication number
20240351222
Publication date
Oct 24, 2024
Virginia Commonwealth University
Logan Schorr
B22 - CASTING POWDER METALLURGY
Information
Patent Application
SPUTTERING MACHINES, SUBSTRATE HOLDERS, AND SPUTTERING PROCESSES WI...
Publication number
20240337009
Publication date
Oct 10, 2024
Virginia Commonwealth University
Santiago Vargas GIRALDO
C23 - COATING METALLIC MATERIAL COATING MATERIAL WITH METALLIC MATERIAL CHEMI...
Information
Patent Application
3D-PRINTED ARTIFICIAL CILIA ARRAY MECHANOSENSING TOOL
Publication number
20240328840
Publication date
Oct 3, 2024
Virginia Commonwealth University
Philip GLASS
B29 - WORKING OF PLASTICS WORKING OF SUBSTANCES IN A PLASTIC STATE, IN GENERAL
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Patent Application
MINI CIRCULAR RNA THERAPEUTICS AND VACCINES AND METHODS OF USE THEREOF
Publication number
20240299520
Publication date
Sep 12, 2024
Virginia Commonwealth University
Guizhi ZHU
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Application
SELF-CALIBRATED ELECTROCHEMICAL SENSORS
Publication number
20240295524
Publication date
Sep 5, 2024
Virginia Commonwealth University
Xuewei WANG
G01 - MEASURING TESTING
Information
Patent Application
BRAIN PHANTOM WITH EMBEDDED SENSORS FOR BRAIN INJURY MODELING
Publication number
20240296755
Publication date
Sep 5, 2024
Virginia Commonwealth University
Ravi L. Hadimani
G09 - EDUCATION CRYPTOGRAPHY DISPLAY ADVERTISING SEALS
Information
Patent Application
TEM Orientation Mapping via Dark-Field Vector Images
Publication number
20240272097
Publication date
Aug 15, 2024
Virginia Commonwealth University
Carl R. Mayer
G01 - MEASURING TESTING
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Patent Application
METHODS AND COMPOSITIONS FOR DETERMINATION NON-ALCOHOLIC FATTY LIVE...
Publication number
20240272181
Publication date
Aug 15, 2024
The Regents of the University of California
Edward A. Dennis
G01 - MEASURING TESTING
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NSF Awards
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Characterizing hominin diversification through an ecological approach
Award Id
2419597
Effective date
Oct 15, 2024
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Postdoctoral Fellowship: STEMEdIPRF: Identifying and Developing Gra...
Award Id
2411661
Effective date
Oct 1, 2024
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Exploring Student Interactions in Small Groups in Belonging-Oriente...
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2400902
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Leveraging Scholarships and Vertically Integrated Projects to Incre...
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2424795
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Expanding and Enhancing Methodologies to Obtain Deeper Insights abo...
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2422267
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Variational Problems and Patterns in Materials Science: Martensitic...
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2408507
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MCA: Disentangling demography and adaptation during the evolution o...
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2423013
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Collaborative Research: Co-doping of ultra/wide-bandgap III-nitride...
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2423874
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Geometry of Moduli Spaces and Metaplectic Representations
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2404896
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Conference: Mid-Atlantic Algebra, Geometry, and Combinatorics Workshop
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2408985
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Travel: NSF Student Travel Grant for the 2024 IEEE International Co...
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2425733
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Travel: NSF Student Travel Grant for 2024 Digital Forensics Researc...
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2409934
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Equipment: MRI: Track 1 Acquisition of NVIDIA DGX H100 GPU system f...
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2316003
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Conference: GRANTED Building a Regional Research Ecosystem among Em...
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2324405
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Collaborative Research: IHBEM: Multidisciplinary Analysis of Vaccin...
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2327790
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Laser Directed Energy Deposition Processing of Exchange-Biased Bulk...
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2310234
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Improving the LC Separation of Biomolecule Mixtures using Novel Mix...
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2305102
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Nonlocal Variational Problems from Physical and Biological Models
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2306962
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Student Support for Magnetic Technologies and Clinical Applications...
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2336233
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Collaborative Research: CQIS: On-Chip Nanoscale Trap and Enhance De...
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2322891
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Engineering a Kidney Organoid Model to Investigate Fibronectin-TGF-...
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2302580
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Collaborative Research: Tailoring the Catalytic Properties of Pd Si...
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2308631
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MCA: Mid-Career Advancement - Using STEM Interest Profiling to Buil...
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2308622
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I-Corps: Personalized Human Brain Phantom for Neuromodulation Proc...
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2304513
Effective date
Apr 15, 2023
Information
NSF Award
BCSER - PVEST: A Dynamic Framework for Investigating STEM Interest,...
Award Id
2327055
Effective date
Feb 1, 2023
Information
NSF Award
IPA Action
Award Id
2314106
Effective date
Jan 17, 2023
Information
NSF Award
Collaborative Research: AMPS: Rethinking State Estimation for Power...
Award Id
2229075
Effective date
Jan 1, 2023
Information
NSF Award
ExpandQISE: Track 1: Energy Efficient Quantum Control of Robust Spi...
Award Id
2231356
Effective date
Sep 1, 2022
Information
NSF Award
Explorations in Entanglement and Knotting in Low-Dimensional Topology
Award Id
2204148
Effective date
Aug 1, 2022
Information
NSF Award
LSAMP BD: Virginia Commonwealth University, Virginia-North Carolina...
Award Id
2204703
Effective date
Aug 1, 2022
NIH Research Project
last 12 months
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Count: 30
Research Projects
Information
Research Project
WEEKEND PROGRAM FOR REGISTERED NURSE STUDENTS
Application id
3003846
Award notice date
Jan 1, 2999
Information
Research Project
Establishing Biomarkers and Clinical Endpoints in Myotonic Dystroph...
Application id
10496809
Award notice date
Sep 29, 2021
Information
Research Project
The role of sulfatide in myelin stability
Application id
10373193
Award notice date
Sep 24, 2021
Information
Research Project
Nucleic acid modulators and theranostics for ADAR
Application id
10276650
Award notice date
Sep 17, 2021
Information
Research Project
Preventing Firearm Violence in Youth: A hospital-based prevention s...
Application id
10399852
Award notice date
Sep 17, 2021
Information
Research Project
VCU Healthy Communities for Youth: Evaluation of Violence Preventio...
Application id
10396332
Award notice date
Sep 17, 2021
Information
Research Project
Liver Cirrhosis Network: Clinical Research Centers
Application id
10308126
Award notice date
Sep 10, 2021
Information
Research Project
Incorporating a developmental perspective into gene identification...
Application id
10389028
Award notice date
Sep 8, 2021
Information
Research Project
Adolescent Binge Ethanol Dysregulation of H3K36me3 Leads to Cryptic...
Application id
10314644
Award notice date
Sep 8, 2021
Information
Research Project
Varieties of Impulsivity in Opiate and Stimulant Users
Application id
10299799
Award notice date
Sep 2, 2021
Information
Research Project
Practice Facilitation to Promote Evidence-based Screening and Manag...
Application id
10260467
Award notice date
Sep 2, 2021
Information
Research Project
The relative impact of the Hippo and RB tumor suppressor pathways i...
Application id
10239225
Award notice date
Aug 31, 2021
Information
Research Project
Whole Genome Sequencing in Irish Multiplex Schizophrenia Families
Application id
10252765
Award notice date
Aug 31, 2021
Information
Research Project
Project 3: Using abuse liability data to test hypotheses about adva...
Application id
10245302
Award notice date
Aug 30, 2021
Information
Research Project
Administrative Core
Application id
10245299
Award notice date
Aug 30, 2021
Information
Research Project
Project 1: Using toxicity testing data to test hypotheses about adv...
Application id
10245300
Award notice date
Aug 30, 2021
Information
Research Project
Center for the Study of Tobacco Products
Application id
10245298
Award notice date
Aug 30, 2021
Information
Research Project
Career Enhancement Core
Application id
10245304
Award notice date
Aug 30, 2021
Information
Research Project
Contextual Knowledge Core
Application id
10245305
Award notice date
Aug 30, 2021
Information
Research Project
Project 4: Using a prospective cohort survey to test population-lev...
Application id
10245303
Award notice date
Aug 30, 2021
Information
Research Project
Project 2: Using user behavior data collected in the clinical lab t...
Application id
10245301
Award notice date
Aug 30, 2021
Information
Research Project
Administrative Supplement: ?Mamma Mia?: A multisite randomized cont...
Application id
10382034
Award notice date
Aug 26, 2021
Information
Research Project
The Trojan Horse Hypothesis: Neutrophil Elastase Reprograms Macroph...
Application id
10191015
Award notice date
Aug 25, 2021
Information
Research Project
Mechanisms of B-Myb oncogenicity in ovarian cancer
Application id
10112196
Award notice date
Aug 25, 2021
Information
Research Project
Metformin Therapy for Ischemic Insult and Reperfusion Injury in Aging
Application id
10298194
Award notice date
Aug 25, 2021
Information
Research Project
Measurement of Neuroexcitation during Bladder Filling: A Novel Metr...
Application id
10191877
Award notice date
Aug 25, 2021
Information
Research Project
Genetic and Neural Factors in Alcohol-Influenced Aggression
Application id
10234075
Award notice date
Aug 25, 2021
Information
Research Project
Gut dysbiosis and 5-HT2A dysregulation in a preclinical schizophren...
Application id
10242023
Award notice date
Aug 24, 2021
Information
Research Project
Development of a Novel Personalized Risk Assessment for College Alc...
Application id
10231041
Award notice date
Aug 24, 2021
Information
Research Project
Using transmitted and untransmitted gene networks to identify molec...
Application id
10298865
Award notice date
Aug 19, 2021