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Mark K. Schlegel
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Boston, MA, US
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Patents Grants
last 30 patents
Information
Patent Grant
Complement component C3 iRNA compositions and methods of use thereof
Patent number
12,365,896
Issue date
Jul 22, 2025
Alnylam Pharmaceuticals, Inc.
Mark Keating
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Grant
Coagulation factor V (F5) iRNA compositions and methods of use thereof
Patent number
12,331,297
Issue date
Jun 17, 2025
Alnylam Pharmaceuticals, Inc.
Mark Keating
A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information
Patent Grant
Modified RNA agents with reduced off-target effect
Patent number
12,275,938
Issue date
Apr 15, 2025
Alnylam Pharmaceuticals, Inc.
Shigeo Matsuda
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Grant
Complement component C3 iRNA compositions and methods of use thereof
Patent number
12,258,565
Issue date
Mar 25, 2025
Alnylam Pharmaceuticals, Inc.
Mark Keating
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Grant
Modified RNA agents with reduced off-target effect
Patent number
12,247,203
Issue date
Mar 11, 2025
Alnylam Pharmaceuticals, Inc.
Shigeo Matsuda
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Grant
Hepatitis B virus (HBV) dsRNA agent compositions and methods of use...
Patent number
12,173,289
Issue date
Dec 24, 2024
Alnylam Pharmaceuticals, Inc.
Vasant R. Jadhav
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Grant
Factor XII (F12) iRNA compositions and methods of use thereof
Patent number
12,049,630
Issue date
Jul 30, 2024
Alnylam Pharmaceuticals, Inc.
Karyn Schmidt
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Grant
Huntingtin (HTT) iRNA agent compositions and methods of use thereof
Patent number
11,993,774
Issue date
May 28, 2024
Alnylam Pharmaceuticals, Inc.
Mangala Meenakshi Soundarapandian
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Grant
Complement factor B (CFB) iRNA compositions and methods of use thereof
Patent number
11,965,166
Issue date
Apr 23, 2024
Alnylam Pharmaceuticals, Inc.
James D. McIninch
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Grant
Transthyretin (TTR) iRNA compositions and methods of use thereof
Patent number
11,959,081
Issue date
Apr 16, 2024
Alnylam Pharmaceuticals, Inc.
Mark K. Schlegel
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Grant
Ketohexokinase (KHK) iRNA compositions and methods of use thereof
Patent number
11,926,832
Issue date
Mar 12, 2024
Alnylam Pharmaceuticals, Inc.
Leila Noetzli
A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information
Patent Grant
Transmembrane protease, serine 6 (TMPRSS6) iRNA compositions and me...
Patent number
11,866,710
Issue date
Jan 9, 2024
Alnylam Pharmaceuticals, Inc.
Aimee M. Deaton
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Grant
Angiotensinogen (AGT) iRNA compositions and methods of use thereof
Patent number
11,834,661
Issue date
Dec 5, 2023
Alnylam Pharmaceuticals, Inc.
Donald Foster
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Grant
Serpina1 iRNA compositions and methods of use thereof
Patent number
11,725,207
Issue date
Aug 15, 2023
Alnylam Pharmaceuticals, Inc.
Mark K. Schlegel
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Grant
Superoxide dismutase 1 (SOD1) iRNA compositions and methods of use...
Patent number
11,649,459
Issue date
May 16, 2023
Alnylam Pharmaceuticals, Inc.
Adam Castoreno
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Grant
Angiopoietin-like 3 (ANGPTL3) iRNA compositions and methods of use...
Patent number
11,613,751
Issue date
Mar 28, 2023
Alnylam Pharmaceuticals, Inc.
Lucas D. BonDurant
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Grant
Chirally-enriched double-stranded RNA agents
Patent number
11,597,932
Issue date
Mar 7, 2023
Alnylam Pharmaceuticals, Inc.
Muthiah Manoharan
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Grant
Modified RNA agents with reduced off-target effect
Patent number
11,504,391
Issue date
Nov 22, 2022
Alnylam Pharmaceuticals, Inc.
Mark K. Schlegel
A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information
Patent Grant
Hepatitis B virus (HBV) dsRNA agent compositions and methods of use...
Patent number
11,492,623
Issue date
Nov 8, 2022
Alnylam Pharmaceuticals, Inc.
Vasant R. Jadhav
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Grant
Xanthine dehydrogenase (XDH) iRNA compositions and methods of use t...
Patent number
11,326,166
Issue date
May 10, 2022
Alnylam Pharmaceuticals, Inc.
James D. McIninch
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Grant
Coronavirus iRNA compositions and methods of use thereof
Patent number
11,208,660
Issue date
Dec 28, 2021
Alnylam Pharmaceuticals, Inc.
Akin Akinc
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Grant
Apolipoprotein C3 (APOC3) iRNA compositions and methods of use thereof
Patent number
11,162,103
Issue date
Nov 2, 2021
Alnylam Pharmaceuticals, Inc.
Frederic Tremblay
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Grant
Patatin-like phospholipase domain containing 3 (PNPLA3) iRNA compos...
Patent number
11,149,276
Issue date
Oct 19, 2021
Alnylam Pharmaceuticals, Inc.
Frederic Tremblay
A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information
Patent Grant
Angiotensinogen (AGT) iRNA compositions and methods of use thereof
Patent number
11,015,201
Issue date
May 25, 2021
Alnylam Pharmaceuticals, Inc.
Donald Foster
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Grant
Serpina1 iRNA compositions and methods of use thereof
Patent number
10,995,336
Issue date
May 4, 2021
Alnylam Pharmaceuticals, Inc.
Mark K. Schlegel
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Patents Applications
last 30 patents
Information
Patent Application
MODIFIED RNA AGENTS WITH REDUCED OFF-TARGET EFFECT
Publication number
20250205272
Publication date
Jun 26, 2025
Alnylam Pharmaceuticals, Inc.
Mark K. SCHLEGEL
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Application
MODIFIED RNA AGENTS WITH REDUCED OFF-TARGET EFFECT
Publication number
20250207131
Publication date
Jun 26, 2025
Alnylam Pharmaceuticals, Inc.
Shigeo MATSUDA
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Application
SNCA-TARGETING SIRNA COMPOSITIONS FOR TREATING SNCA-ASSOCIATED DISEASE
Publication number
20250115911
Publication date
Apr 10, 2025
Alnylam Pharmaceuticals, Inc.
Lan Thi Hoang Dang
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Application
COMPOSITIONS AND METHODS FOR SILENCING CARBONIC ANHYDRASE 2 EXPRESSION
Publication number
20250084418
Publication date
Mar 13, 2025
Alnylam Pharmaceuticals, Inc.
JEFFREY ZUBER
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Application
SNCA-TARGETING SIRNA COMPOSITIONS FOR TREATING SNCA-ASSOCIATED DISEASE
Publication number
20250059541
Publication date
Feb 20, 2025
Alnylam Pharmaceuticals, Inc.
Lan Thi Hoang Dang
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Application
CELL DEATH-INDUCING DFFA-LIKE EFFECTOR B (CIDEB) IRNA COMPOSITIONS...
Publication number
20250059542
Publication date
Feb 20, 2025
Alnylam Pharmaceuticals, Inc.
JEFFREY ZUBER
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Application
iRNA Compositions and Methods for Silencing MYLIP
Publication number
20250051767
Publication date
Feb 13, 2025
Alnylam Pharmaceuticals, Inc.
LUCAS WARD
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Application
SERPINA1 iRNA COMPOSITIONS AND METHODS OF USE THEREOF
Publication number
20250043279
Publication date
Feb 6, 2025
Alnylam Pharmaceuticals, Inc.
Mark K. Schlegel
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Application
CELL DEATH-INDUCING DFFA-LIKE EFFECTOR B (CIDEB) IRNA COMPOSITIONS...
Publication number
20250034567
Publication date
Jan 30, 2025
Alnylam Pharmaceuticals, Inc.
JEFFREY ZUBER
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Application
COMPLEMENT FACTOR B (CFB) IRNA COMPOSITIONS AND METHODS OF USE THEREOF
Publication number
20250027080
Publication date
Jan 23, 2025
Alnylam Pharmaceuticals, Inc.
James D. McIninch
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Application
HUNTINGTIN (HTT) IRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF
Publication number
20250011776
Publication date
Jan 9, 2025
Alnylam Pharmaceuticals, Inc.
William Cantley
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Application
TRANSTHYRETIN (TTR) IRNA COMPOSITIONS AND METHODS OF USE THEREOF
Publication number
20240409929
Publication date
Dec 12, 2024
Alnylam Pharmaceuticals, Inc.
Mark K. Schlegel
A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information
Patent Application
FACTOR XII (F12) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
Publication number
20240401056
Publication date
Dec 5, 2024
Alnylam Pharmaceuticals, Inc.
Karyn Schmidt
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Application
IRNA COMPOSITIONS AND METHODS FOR SILENCING ANGIOTENSINOGEN (AGT)
Publication number
20240392294
Publication date
Nov 28, 2024
Alnylam Pharmaceuticals, Inc.
Paul Nioi
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Application
HUNTINGTIN (HTT) IRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF
Publication number
20240368594
Publication date
Nov 7, 2024
Alnylam Pharmaceuticals, Inc.
Mangala Meenakshi Soundarapandian
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Application
2'-MODIFIED NUCLEOSIDE BASED OLIGONUCLEOTIDE PRODRUGS
Publication number
20240336914
Publication date
Oct 10, 2024
Alnylam Pharmaceuticals, Inc.
Shigeo MATSUDA
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Application
PATATIN-LIKE PHOSPHOLIPASE DOMAIN CONTAINING 3 (PNPLA3) iRNA COMPOS...
Publication number
20240318184
Publication date
Sep 26, 2024
Alnylam Pharmaceuticals, Inc.
Ho-Chou Tu
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Application
Compositions and Methods for Silencing MYOC Expression
Publication number
20240318175
Publication date
Sep 26, 2024
Alnylam Pharmaceuticals, Inc.
ADAM CASTORENO
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Application
iRNA Compositions and Methods for Silencing Filamin A (FLNA)
Publication number
20240301418
Publication date
Sep 12, 2024
Alnylam Pharmaceuticals, Inc.
KIRK BROWN
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Application
LEUCINE-RICH REPEAT KINASE 2 (LRRK2) IRNA AGENT COMPOSITIONS AND ME...
Publication number
20240301426
Publication date
Sep 12, 2024
Alnylam Pharmaceuticals, Inc.
LAN THI HOANG DANG
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Application
ATXN2 IRNA COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING OR...
Publication number
20240294906
Publication date
Sep 5, 2024
Alnylam Pharmaceuticals, Inc.
Elane Fishilevich
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Application
MICROTUBULE ASSOCIATED PROTEIN TAU (MAPT) iRNA AGENT COMPOSITIONS A...
Publication number
20240254487
Publication date
Aug 1, 2024
Alnylam Pharmaceuticals, Inc.
JONATHAN EDWARD FARLEY
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Application
COMPOSITIONS AND METHODS FOR SILENCING CARBONIC ANHYDRASE 2 EXPRESSION
Publication number
20240254493
Publication date
Aug 1, 2024
Alnylam Pharmaceuticals, Inc.
JEFFREY ZUBER
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Application
COAGULATION FACTOR V (F5) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
Publication number
20240218366
Publication date
Jul 4, 2024
Alnylam Pharmaceuticals, Inc.
Mark Keating
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Application
iRNA COMPOSITIONS AND METHODS FOR SILENCING CHITINASE 3-LIKE PROTEI...
Publication number
20240209374
Publication date
Jun 27, 2024
Alnylam Pharmaceuticals, Inc.
Bret L. Bostwick
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Application
COMPLEMENT COMPONENT C3 IRNA COMPOSITIONS AND METHODS OF USE THEREOF
Publication number
20240209369
Publication date
Jun 27, 2024
Alnylam Pharmaceuticals, Inc.
Mark Keating
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Application
COAGULATION FACTOR V (F5) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
Publication number
20240209358
Publication date
Jun 27, 2024
Alnylam Pharmaceuticals, Inc.
Mark Keating
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Application
ANGIOTENSINOGEN (AGT) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
Publication number
20240191236
Publication date
Jun 13, 2024
Alnylam Pharmaceuticals, Inc.
Donald Foster
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Application
TRANSMEMBRANE PROTEASE, SERINE 6 (TMPRSS6) iRNA COMPOSITIONS AND ME...
Publication number
20240182905
Publication date
Jun 6, 2024
Alnylam Pharmaceuticals, Inc.
Aimee M. Deaton
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Application
SUPEROXIDE DISMUTASE 1 (SOD1) iRNA COMPOSITIONS AND METHODS OF USE...
Publication number
20240150767
Publication date
May 9, 2024
Alnylam Pharmaceuticals, Inc.
Adam Castoreno
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...