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C12M23/14

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CCHEMISTRY METALLURGY C12Biochemistry C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS C12M23/00Constructional details

Current Industry

C12M23/14Bags

Industries

Patents Grantslast 30 patents

Information Patent Grant
Single-use centrifuge containers for separating biological suspensi...
- Patent number 11,666,925
- Issue date Jun 6, 2023
- Thermo Electron LED GmbH
- Romana Hinz
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Bioprocess vessels with integrated pump
- Patent number 11,666,508
- Issue date Jun 6, 2023
- ALPHINITY USA, INC.
- Michael C. Gagne
- B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
Information Patent Grant
Tank with door locking mechanism
- Patent number 11,649,654
- Issue date May 16, 2023
- Cytiva US LLC
- Jorrit Sevenants
- E05 - LOCKS KEYS WINDOW OR DOOR FITTINGS SAFES
Information Patent Grant
Illuminated container for growth of biological entities
- Patent number 11,643,630
- Issue date May 9, 2023
- Corning Incorporated
- Edward John Fewkes
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Housing for holding a flexible bioprocess bag
- Patent number 11,643,627
- Issue date May 9, 2023
- Cytiva Sweden AB
- Klaus Gebauer
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Oxygen reduction disposable kits, devices and methods of use thereof
- Patent number 11,638,421
- Issue date May 2, 2023
- Hemanext Inc.
- Michael Wolf
- A01 - AGRICULTURE FORESTRY ANIMAL HUSBANDRY HUNTING TRAPPING FISHING
Information Patent Grant
Bioreactor including a rocking device
- Patent number 11,613,726
- Issue date Mar 28, 2023
- Cytiva Sweden AB
- Andreas Andersson
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Single-use connection device
- Patent number 11,608,484
- Issue date Mar 21, 2023
- Eppendorf AG
- Matthias Arnold
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Variable diameter bioreactors
- Patent number 11,597,900
- Issue date Mar 7, 2023
- Lonza Ltd
- Michael Mietzner
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Stirred tank reactor systems and methods of use
- Patent number 11,591,556
- Issue date Feb 28, 2023
- Life Technologies Corporation
- Kurt T. Kunas
- B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
Information Patent Grant
Method for producing a biodigester reactor and membrane template
- Patent number 11,582,895
- Issue date Feb 21, 2023
- BUEN MANEJO DEL CAMPO, S.A. DE C.V.
- Alexander Bennet Eaton
- A01 - AGRICULTURE FORESTRY ANIMAL HUSBANDRY HUNTING TRAPPING FISHING
Information Patent Grant
Apparatus and methods for adjustable volume cell culture
- Patent number 11,566,218
- Issue date Jan 31, 2023
- GLOBAL LIFE SCIENCES SOLUTIONS USA LLC
- Nagaraju Konduru
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Methods for gas filteration in fluid processing systems
- Patent number 11,554,335
- Issue date Jan 17, 2023
- Life Technologies Corporation
- Jason D. Brown
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Device and method for monitoring the temperature of a cryopreserved...
- Patent number 11,549,851
- Issue date Jan 10, 2023
- Fraunhofer-Gesellschaft zur Foerderung der angewandten Forschung e.V.
- Guenter R. Fuhr
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Bioreactor with addition tube
- Patent number 11,549,091
- Issue date Jan 10, 2023
- Cytiva Sweden AB
- Andreas Castan
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
System and method for packaging a bioprocessing bag and associated...
- Patent number 11,535,421
- Issue date Dec 27, 2022
- GLOBAL LIFE SCIENCES SOLUTIONS USA LLC
- Steven Forsberg
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Control system and method for a fluid mixing apparatus
- Patent number 11,529,598
- Issue date Dec 20, 2022
- Life Technologies Corporation
- Joshua Mead
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Cell separation device, method and system
- Patent number 11,524,293
- Issue date Dec 13, 2022
- Sartorius Stedim North America Inc.
- Grishma Patel
- B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
Information Patent Grant
Failure recovery in cell culture bioreactors
- Patent number 11,525,112
- Issue date Dec 13, 2022
- GLOBAL LIFE SCIENCES SOLUTIONS USA LLC
- Manoj Ramakrishna
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Bag assembly for cultivation of cells
- Patent number 11,525,111
- Issue date Dec 13, 2022
- Cytiva Sweden AB
- Klaus Gebauer
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Movable cell incubator
- Patent number 11,518,972
- Issue date Dec 6, 2022
- Lun-Kuang Liu
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Sterile sensor insertion
- Patent number 11,499,126
- Issue date Nov 15, 2022
- GLOBAL LIFE SCIENCES SOLUTIONS USA LLC
- Vincent Francis Pizzi
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Heat exchanger system with flexible bag
- Patent number 11,492,582
- Issue date Nov 8, 2022
- Life Technologies Corporation
- Clinton C. Staheli
- F28 - HEAT EXCHANGE IN GENERAL
Information Patent Grant
Hollow fiber filter arrangement
- Patent number 11,485,947
- Issue date Nov 1, 2022
- GLOBAL LIFE SCIENCES SOLUTIONS USA LLC
- Yasser Ali
- B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
Information Patent Grant
Organ container
- Patent number 11,459,534
- Issue date Oct 4, 2022
- SCREEN Holdings Co., Ltd.
- Shinji Torai
- A01 - AGRICULTURE FORESTRY ANIMAL HUSBANDRY HUNTING TRAPPING FISHING
Information Patent Grant
Bioreactor system and method of bioprocessing
- Patent number 11,447,730
- Issue date Sep 20, 2022
- GLOBAL LIFE SCIENCES SOLUTIONS USA LLC
- Alexander Mark Kilar
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Substrates for high-density cell growth and metabolite exchange
- Patent number 11,414,636
- Issue date Aug 16, 2022
- California Institute of Technology
- Yu-Chong Tai
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Cell processing system and method with fill options
- Patent number 11,401,494
- Issue date Aug 2, 2022
- Fenwal, Inc.
- Steven C. Binninger
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Shaking culture apparatus and culture method using the same
- Patent number 11,390,838
- Issue date Jul 19, 2022
- Fujimori Kogyo Co., Ltd.
- Hiroyuki Matsuda
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Single-use bioreactor port with multiple sensors
- Patent number 11,384,325
- Issue date Jul 12, 2022
- Rosemount Inc.
- Mark S. Schumacher
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...

Patents Applicationslast 30 patents

Information Patent Application
SYSTEM AND METHOD FOR MONITORING AND REGULATING THE LEVEL OF THE CO...
- Publication number 20230168518
- Publication date Jun 1, 2023
- Merck Patent GmbH
- Laurent Jourdainne
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Apparatus, kit and a method for the provision and use of Electromag...
- Publication number 20230159879
- Publication date May 25, 2023
- St Andrews Pharmaceutical Technology Limited
- William J. Henry
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
CELL CULTURE SYSTEM
- Publication number 20230151318
- Publication date May 18, 2023
- MICRO DIGITAL CO., LTD
- Kyung Nam KIM
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
CELL CULTURE VESSEL, METHOD FOR PRODUCING CELL CULTURE VESSEL, METH...
- Publication number 20230134478
- Publication date May 4, 2023
- TOYO SEIKAN GROUP HOLDINGS, LTD.
- Osamu KOSEKI
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
DETECTING FOAM IN A BIOREACTOR PLANT
- Publication number 20230125762
- Publication date Apr 27, 2023
- Sartorius Stedim Biotech GmbH
- Andreas Prediger
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
HYBRID SYSTEM OF CULTURE AND PURIFICATION PROCESS FOR MANUFACTURING...
- Publication number 20230128089
- Publication date Apr 27, 2023
- PRESTIGE BIOLOGICS CO., LTD.
- Joo Yang PARK
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Heat Exchanger System with Flexible Bag
- Publication number 20230117671
- Publication date Apr 20, 2023
- Life Technologies Corporation
- Clinton C. Staheli
- F28 - HEAT EXCHANGE IN GENERAL
Information Patent Application
Control Systems For A Fluid Mixing Apparatus
- Publication number 20230123126
- Publication date Apr 20, 2023
- Life Technologies Corporation
- Joshua Mead
- B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
Information Patent Application
PLATFORMS AND SYSTEMS FOR AUTOMATED CELL CULTURE
- Publication number 20230095664
- Publication date Mar 30, 2023
- CELLINO BIOTECH, INC.
- Matthias WAGNER
- G06 - COMPUTING CALCULATING COUNTING
Information Patent Application
BIOREACTOR WITH ADDITION TUBE
- Publication number 20230093940
- Publication date Mar 30, 2023
- CYTIVA SWEDEN AB
- Andreas Castan
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Methods for Mixing a Fluid with Foldable Impellers
- Publication number 20230093549
- Publication date Mar 23, 2023
- Life Technologies Corporation
- Clinton C. Staheli
- B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
Information Patent Application
Methods for Gas Filtration in Fluid Processing Systems
- Publication number 20230081070
- Publication date Mar 16, 2023
- LIFE TECHNOLOGIES CORPORATION
- Jason D. Brown
- B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
Information Patent Application
SYSTEM AND METHOD FOR PACKAGING A BIOPROCESSING BAG AND ASSOCIATED...
- Publication number 20230082880
- Publication date Mar 16, 2023
- GLOBAL LIFE SCIENCES SOLUTIONS USA LLC
- STEVEN FORSBERG
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
PERFUSION FILTER ASSEMBLY FOR INCREASED CROSS FLOW
- Publication number 20230066761
- Publication date Mar 2, 2023
- GLOBAL LIFE SCIENCES SOLUTIONS USA LLC
- Ralph Stankowski
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
PERFUSION FILTER MEMBRANE ASSEMBLY
- Publication number 20230065984
- Publication date Mar 2, 2023
- GLOBAL LIFE SCIENCES SOLUTIONS USA LLC
- Douglas Albagli
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Single-Use Bioprocessing Bag for Growing Cell Media, and Multilayer...
- Publication number 20230060563
- Publication date Mar 2, 2023
- Tekni-Plex, Inc.
- Robin Van Landeghem
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
PLATFORMS AND SYSTEMS FOR AUTOMATED CELL CULTURE
- Publication number 20230065504
- Publication date Mar 2, 2023
- CELLINO BIOTECH, INC.
- Matthias WAGNER
- G06 - COMPUTING CALCULATING COUNTING
Information Patent Application
ASEPTIC YEAST TRANSFER APPARATUS AND METHOD
- Publication number 20230055476
- Publication date Feb 23, 2023
- WHITE LABS
- Chris White
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
CELL PRODUCTION DEVICE AND CELL PRODUCTION METHOD
- Publication number 20230038829
- Publication date Feb 9, 2023
- FANUC CORPORATION
- Kazunori BAN
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Single Use Bioreactor
- Publication number 20230045226
- Publication date Feb 9, 2023
- LONZA LTD.
- Colin Mark Jaques
- B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
Information Patent Application
SYSTEM HAVING A TUBE SHAFT IMPELLER AND AN ASSOCIATED METHOD THEREOF
- Publication number 20230025193
- Publication date Jan 26, 2023
- GLOBAL LIFE SCIENCES SOLUTIONS USA LLC
- Kandakumar Murugesan
- B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
Information Patent Application
METHODS FOR SEPARATING SUSPENSIONS USING SINGLE-USE CENTRIFUGE CONT...
- Publication number 20230023994
- Publication date Jan 26, 2023
- THERMO ELECTRON LED GMBH
- Romana Hinz
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
ASEPTIC BIOPROCESS PACKAGE
- Publication number 20220411737
- Publication date Dec 29, 2022
- Corning Incorporated
- Vasiliy Nikolaevich Goral
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
METHOD OF FORMING A COLLAPSIBLE BAG USING A MOLD AND MANDREL
- Publication number 20220388725
- Publication date Dec 8, 2022
- GLOBAL LIFE SCIENCES SOLUTIONS USA LLC
- PARRISH M. GALLIHER
- B29 - WORKING OF PLASTICS WORKING OF SUBSTANCES IN A PLASTIC STATE, IN GENERAL
Information Patent Application
BIOLOGICAL COMPONENT CASSETTE, BIOLOGICAL COMPONENT KIT, AND BIOLOG...
- Publication number 20220378988
- Publication date Dec 1, 2022
- Terumo Kabushiki Kaisha
- Masatsugu IGARASHI
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Food Materials Comprising Filamentous Fungal Particles and Membrane...
- Publication number 20220372420
- Publication date Nov 24, 2022
- The Fynder Group, Inc.
- Richard Eugene Macur
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
FLOW PATH CASSETTE, CELL CULTURING KIT, AND CELL CULTURING SYSTEM
- Publication number 20220348857
- Publication date Nov 3, 2022
- Terumo Kabushiki Kaisha
- MASATSUGU IGARASHI
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
METHODS AND COMPOSITIONS FOR DELIVERING COMPACT LYOPHILIZED AGENTS...
- Publication number 20220348853
- Publication date Nov 3, 2022
- Bio-Techne Corporation
- Timothy John Manning
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Substrates for High-Density Cell Growth and Metabolite Exchange
- Publication number 20220348856
- Publication date Nov 3, 2022
- California Institute of Technology
- Yu-Chong Tai
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
BIOREACTOR SYSTEM AND APPLICATION THEREOF
- Publication number 20220333049
- Publication date Oct 20, 2022
- Zhejiang Jinyishengshi Bioengineering Co.,Ltd
- Shun LUO
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...

Industry

Parent Industries

Current Industry

Patents Grantslast 30 patents

Single-use centrifuge containers for separating biological suspensi...

Bioprocess vessels with integrated pump

Tank with door locking mechanism

Illuminated container for growth of biological entities

Housing for holding a flexible bioprocess bag

Oxygen reduction disposable kits, devices and methods of use thereof

Bioreactor including a rocking device

Single-use connection device

Variable diameter bioreactors

Stirred tank reactor systems and methods of use

Method for producing a biodigester reactor and membrane template

Apparatus and methods for adjustable volume cell culture

Methods for gas filteration in fluid processing systems

Device and method for monitoring the temperature of a cryopreserved...

Bioreactor with addition tube

System and method for packaging a bioprocessing bag and associated...

Control system and method for a fluid mixing apparatus

Cell separation device, method and system

Failure recovery in cell culture bioreactors

Bag assembly for cultivation of cells

Movable cell incubator

Sterile sensor insertion

Heat exchanger system with flexible bag

Hollow fiber filter arrangement

Organ container

Bioreactor system and method of bioprocessing

Substrates for high-density cell growth and metabolite exchange

Cell processing system and method with fill options

Shaking culture apparatus and culture method using the same

Single-use bioreactor port with multiple sensors

Patents Applicationslast 30 patents

SYSTEM AND METHOD FOR MONITORING AND REGULATING THE LEVEL OF THE CO...

Apparatus, kit and a method for the provision and use of Electromag...

CELL CULTURE SYSTEM

CELL CULTURE VESSEL, METHOD FOR PRODUCING CELL CULTURE VESSEL, METH...

DETECTING FOAM IN A BIOREACTOR PLANT

HYBRID SYSTEM OF CULTURE AND PURIFICATION PROCESS FOR MANUFACTURING...

Heat Exchanger System with Flexible Bag

Control Systems For A Fluid Mixing Apparatus

PLATFORMS AND SYSTEMS FOR AUTOMATED CELL CULTURE

BIOREACTOR WITH ADDITION TUBE

Methods for Mixing a Fluid with Foldable Impellers

Methods for Gas Filtration in Fluid Processing Systems

SYSTEM AND METHOD FOR PACKAGING A BIOPROCESSING BAG AND ASSOCIATED...

PERFUSION FILTER ASSEMBLY FOR INCREASED CROSS FLOW

PERFUSION FILTER MEMBRANE ASSEMBLY

Single-Use Bioprocessing Bag for Growing Cell Media, and Multilayer...

PLATFORMS AND SYSTEMS FOR AUTOMATED CELL CULTURE

ASEPTIC YEAST TRANSFER APPARATUS AND METHOD

CELL PRODUCTION DEVICE AND CELL PRODUCTION METHOD

Single Use Bioreactor

SYSTEM HAVING A TUBE SHAFT IMPELLER AND AN ASSOCIATED METHOD THEREOF

METHODS FOR SEPARATING SUSPENSIONS USING SINGLE-USE CENTRIFUGE CONT...

ASEPTIC BIOPROCESS PACKAGE

METHOD OF FORMING A COLLAPSIBLE BAG USING A MOLD AND MANDREL

BIOLOGICAL COMPONENT CASSETTE, BIOLOGICAL COMPONENT KIT, AND BIOLOG...

Food Materials Comprising Filamentous Fungal Particles and Membrane...

FLOW PATH CASSETTE, CELL CULTURING KIT, AND CELL CULTURING SYSTEM

METHODS AND COMPOSITIONS FOR DELIVERING COMPACT LYOPHILIZED AGENTS...

Substrates for High-Density Cell Growth and Metabolite Exchange

BIOREACTOR SYSTEM AND APPLICATION THEREOF