Demonstrated in vivo effect

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CPC
C12N2710/10371

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CCHEMISTRY METALLURGY C12Biochemistry C12NMICRO-ORGANISMS OR ENZYMES COMPOSITIONS THEREOF PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS MUTATION OR GENETIC ENGINEERING CULTURE MEDIA C12N2710/00dsDNA Viruses

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C12N2710/10371Demonstrated in vivo effect

Industries

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Patents Grantslast 30 patents

Information Patent Grant
Oncolytic adenovirus with enhanced replication properties comprisin...
- Patent number 12,365,878
- Issue date Jul 22, 2025
- Salk Institute for Biological Studies
- Clodagh O'Shea
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Covalently-modified steroid acid-peptides having enhanced stability...
- Patent number 12,233,130
- Issue date Feb 25, 2025
- DEFENCE THERAPEUTICS INC.
- Simon Beaudoin
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Adenoviral vector system for gene delivery
- Patent number 12,220,454
- Issue date Feb 11, 2025
- Purdue Research Foundation
- Suresh Kumar Mittal
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Immunogenic compositions and uses thereof
- Patent number 12,178,868
- Issue date Dec 31, 2024
- Board of Regents, The University of Texas System
- Maria A. Croyle
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Oncolytic adenoviruses for treating cancer
- Patent number 12,129,280
- Issue date Oct 29, 2024
- FUNDACIÓ INSTITUT D'INVESTIGACIÓ BIOMEDICA DE BELLVITGE
- Sònia Guedan Carrió
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Modified adenoviruses
- Patent number 12,098,383
- Issue date Sep 24, 2024
- GRITSTONE BIO, INC.
- Karin Jooss
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Immunomodulatory fusion proteins
- Patent number 12,054,530
- Issue date Aug 6, 2024
- EpicentRx, Inc.
- Christopher Larson
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Therapeutic compositions and methods of use for treating cancer
- Patent number 12,023,362
- Issue date Jul 2, 2024
- AGALIMMUNE LIMITED
- Uri Galili
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Virus
- Patent number 12,016,949
- Issue date Jun 25, 2024
- iosBio Ltd
- Jeffrey Drew
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Compositition and uses of teleost invariant chain to enhance T cell...
- Patent number 11,912,743
- Issue date Feb 27, 2024
- Nouscom AG
- Alfredo Nicosia
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Methods and compositions for producing an adenovirus vector for use...
- Patent number 11,826,417
- Issue date Nov 28, 2023
- Etubics Corporation
- Joseph P. Balint
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Immunogenic compositions and uses thereof
- Patent number 11,801,295
- Issue date Oct 31, 2023
- Board of Regents, The University of Texas System
- Maria A. Croyle
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Modified adenoviruses
- Patent number 11,591,619
- Issue date Feb 28, 2023
- GRITSTONE BIO, INC.
- Karin Jooss
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Adenovirus comprising an albumin-binding moiety
- Patent number 11,578,104
- Issue date Feb 14, 2023
- Fundació Institut D'lnvestigació Biomedica De Bellvitge (í DIBELL)
- Ramon Alemany Bonastre
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Methods and compositions for producing an adenovirus vector for use...
- Patent number 11,529,408
- Issue date Dec 20, 2022
- Etubics Corporation
- Joseph P. Balint
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Methods and compositions for producing an adenovirus vector for use...
- Patent number 11,504,423
- Issue date Nov 22, 2022
- Etubics Corporation
- Joseph P. Balint
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Methods and compositions for producing an adenovirus vector for use...
- Patent number 11,389,521
- Issue date Jul 19, 2022
- Etubics Corporation
- Joseph P. Balint
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Breast cancer vaccines and methods of use thereof
- Patent number 11,376,316
- Issue date Jul 5, 2022
- Etubics Corporation
- Joseph P. Balint
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
HPV vaccines and methods of use thereof
- Patent number 11,369,673
- Issue date Jun 28, 2022
- Etubics Corporation
- Joseph P. Balint
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Methods and compositions for combination immunotherapy
- Patent number 11,352,642
- Issue date Jun 7, 2022
- Etubics Corporation
- Frank R. Jones
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Sequential administration of a replication defective adenovirus vec...
- Patent number 11,344,613
- Issue date May 31, 2022
- Etubics Corporation
- Joseph P. Balint
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Adenovirus polynucleotides and polypeptides
- Patent number 11,254,710
- Issue date Feb 22, 2022
- GlaxoSmithKline Biologicals SA
- Stefano Colloca
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Adenovirus polynucleotides and polypeptides
- Patent number 11,254,711
- Issue date Feb 22, 2022
- GlaxoSmithKline Biologicals SA
- Virginia Ammendola
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Adenovirus and uses thereof
- Patent number 11,236,361
- Issue date Feb 1, 2022
- Janssen Vaccines & Prevention B.V.
- Taco Gilles Uil
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Composition for diagnosing, preventing, or treating vascular smooth...
- Patent number 11,219,664
- Issue date Jan 11, 2022
- Chung-Ang University Industry Academic Cooperation Foundation
- Wonhee Suh
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Vectors for expression of prostate-associated antigens
- Patent number 11,173,196
- Issue date Nov 16, 2021
- Pfizer Inc.
- Joseph John Binder
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Oncolytic virus and method
- Patent number 11,142,580
- Issue date Oct 12, 2021
- PSIOXUS THERAPEUTICS LIMITED
- Brian Champion
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Adenoviral vector vaccine
- Patent number 11,027,006
- Issue date Jun 8, 2021
- VAXum, LLC
- Albert B. Deisseroth
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Oncolytic adenovirus encoding a B7 protein
- Patent number 11,000,559
- Issue date May 11, 2021
- PSIOXUS THERAPEUTICS LIMITED
- Brian Robert Champion
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Immunomodulatory fusion proteins
- Patent number 10,906,957
- Issue date Feb 2, 2021
- EpicentRx, Inc.
- Christopher Larson
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE

Patents Applicationslast 30 patents

Information Patent Application
MODIFIED ADENOVIRUSES
- Publication number 20250236884
- Publication date Jul 24, 2025
- Gritstone bio, Inc.
- Karin Jooss
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
IMMUNOMODULATORY FUSION PROTEINS
- Publication number 20250074967
- Publication date Mar 6, 2025
- EpicentRx, Inc.
- Christopher Larson
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
ADENOVIRAL VECTOR SYSTEM FOR GENE DELIVERY
- Publication number 20250057935
- Publication date Feb 20, 2025
- Purdue Research Foundation
- Suresh Kumar Mittal
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
ONCOLYTIC ADENOVIRUSES FOR TREATING CANCER
- Publication number 20250011373
- Publication date Jan 9, 2025
- FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE (IDIBELL)
- Sònia Guedan Carrió
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
VECTOR FOR CANCER TREATMENT
- Publication number 20240401075
- Publication date Dec 5, 2024
- CANCER RESEARCH TECHNOLOGY LIMITED
- Lian Ni LEE
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
COMPOSITIONS, KITS AND METHODS FOR TREATMENT OF COMPLEMENT-RELATED...
- Publication number 20240398898
- Publication date Dec 5, 2024
- Trustees of Tufts College
- Rajendra Kumar-Singh
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
VIRUS
- Publication number 20240374509
- Publication date Nov 14, 2024
- iosBio Ltd
- Jeffrey DREW
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
IMMUNOGENIC COMPOSITIONS AND USES THEREOF
- Publication number 20240374703
- Publication date Nov 14, 2024
- Board of Regents, The University of Texas System
- Maria A. CROYLE
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
IMMUNOGENIC COMPOSITIONS AND USES THEREOF
- Publication number 20240293529
- Publication date Sep 5, 2024
- Board of Regents, The University of Texas System
- Maria A. CROYLE
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
METHODS AND COMPOSITIONS FOR PRODUCING AN ADENOVIRUS VECTOR FOR USE...
- Publication number 20240226266
- Publication date Jul 11, 2024
- ETUBICS CORPORATION
- Joseph P. Balint
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
USE OF ONCOLYTIC ADENOVIRUS FOR THE TREATMENT OF PEDIATRIC BRAIN CA...
- Publication number 20240216492
- Publication date Jul 4, 2024
- DNATRIX, INC.
- Erin MITCHELL
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
COVALENTLY-MODIFIED STEROID ACID-PEPTIDES HAVING ENHANCED STABILITY...
- Publication number 20240207426
- Publication date Jun 27, 2024
- DEFENCE THERAPEUTICS INC.
- Simon BEAUDOIN
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
GORILLA ADENOVIRUS NUCLEIC ACID- AND AMINO ACID-SEQUENCES, VECTORS...
- Publication number 20240002879
- Publication date Jan 4, 2024
- REITHERA SRL
- Stefano Colloca
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
METHODS AND COMPOSITIONS FOR PRODUCING AN ADENOVIRUS VECTOR FOR USE...
- Publication number 20230364218
- Publication date Nov 16, 2023
- ETUBICS CORPORATION
- Joseph P. Balint
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
MESENCHYMAL STEM CELLS THAT ENABLE TUMOR TARGETING IMPROVEMENT AND...
- Publication number 20230210927
- Publication date Jul 6, 2023
- Jae Jin SONG
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
VECTOR FOR CANCER TREATMENT
- Publication number 20230110588
- Publication date Apr 13, 2023
- CANCER RESEARCH TECHNOLOGY LIMITED
- Lian Ni LEE
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
METHODS AND COMPOSITIONS FOR PRODUCING AN ADENOVIRUS VECTOR FOR USE...
- Publication number 20230070595
- Publication date Mar 9, 2023
- ETUBICS CORPORATION
- Joseph P. Balint
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
VISMODEGIB IN COMBINATION WITH A REPLICATION-DEFICIENT TYPE 5 ADENO...
- Publication number 20230065168
- Publication date Mar 2, 2023
- Ascend Biopharmaceuticals Ltd
- Clement Leong
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
METHODS AND COMPOSITIONS FOR PRODUCING AN ADENOVIRUS VECTOR FOR USE...
- Publication number 20220370593
- Publication date Nov 24, 2022
- ETUBICS CORPORATION
- Joseph P. Balint
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
ADENOVIRAL- BASED BIOLOGICAL DELIVERY AND EXPRESSION SYSTEM FOR USE...
- Publication number 20220348963
- Publication date Nov 3, 2022
- Baylor College of Medicine
- Brendan Lee
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
AD36E4ORF1: A THERAPEUTIC TREATMENT FOR ALZHEIMER'S DISEASE
- Publication number 20220288159
- Publication date Sep 15, 2022
- TEXAS TECH UNIVERSITY SYSTEM
- Nikhil V. Dhurandhar
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
METHODS AND COMPOSITIONS FOR PRODUCING AN ADENOVIRUS VECTOR FOR USE...
- Publication number 20220265809
- Publication date Aug 25, 2022
- ETUBICS CORPORATION
- Joseph P. Balint
- C07 - ORGANIC CHEMISTRY
Information Patent Application
AGENT FOR INDUCING SPECIFIC IMMUNITY AGAINST SEVERE ACUTE RESPIRATO...
- Publication number 20220259618
- Publication date Aug 18, 2022
- Federal State Budgetary Institution 'National Research Centre For Epidemiolog...
- Olga Vadimovna ZUBKOVA
- C07 - ORGANIC CHEMISTRY
Information Patent Application
PHARMACEUTICAL AGENT FOR INDUCING SPECIFIC IMMUNITY AGAINST SARS-COV-2
- Publication number 20220226466
- Publication date Jul 21, 2022
- Federal State Budgetary Institution 'National Research Centre For Epidemiolog...
- Olga Vadimovna ZUBKOVA
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
MODIFIED ADENOVIRUSES
- Publication number 20220090138
- Publication date Mar 24, 2022
- Gritstone bio, Inc.
- Karin Jooss
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
ADENOVIRAL-BASED BIOLOGICAL DELIVERY AND EXPRESSION SYSTEM FOR USE...
- Publication number 20220073948
- Publication date Mar 10, 2022
- Baylor College of Medicine
- Brendan Lee
- C07 - ORGANIC CHEMISTRY
Information Patent Application
NOVEL APPLICATION OF HEPARIN-BINDING EPIDERMAL GROWTH FACTOR-LIKE G...
- Publication number 20210138037
- Publication date May 13, 2021
- Kagoshima University
- Ken-ichiro KOSAI
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
MAJOR HISTOCOMPATIBILITY COMPLEX (MHC) COMPOSITIONS AND METHODS OF...
- Publication number 20210060126
- Publication date Mar 4, 2021
- Distributed Bio, Inc.
- Sawsan Youssef
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
ONCOLYTIC ADENOVIRUS COMPOSITIONS WITH ENHANCED REPLICATION PROPERTIES
- Publication number 20210024587
- Publication date Jan 28, 2021
- Salk Institute for Biological Studies
- Clodagh O'Shea
- C07 - ORGANIC CHEMISTRY
Information Patent Application
MODIFIED ONCOLYTIC ADENOVIRUSES
- Publication number 20210017501
- Publication date Jan 21, 2021
- VALO THERAPEUTICS OY
- Tuuli Ranki
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE

Demonstrated in vivo effect

Industry

Parent Industries

Current Industry

Patents Grantslast 30 patents

Oncolytic adenovirus with enhanced replication properties comprisin...

Covalently-modified steroid acid-peptides having enhanced stability...

Adenoviral vector system for gene delivery

Immunogenic compositions and uses thereof

Oncolytic adenoviruses for treating cancer

Modified adenoviruses

Immunomodulatory fusion proteins

Therapeutic compositions and methods of use for treating cancer

Virus

Compositition and uses of teleost invariant chain to enhance T cell...

Methods and compositions for producing an adenovirus vector for use...

Immunogenic compositions and uses thereof

Modified adenoviruses

Adenovirus comprising an albumin-binding moiety

Methods and compositions for producing an adenovirus vector for use...

Methods and compositions for producing an adenovirus vector for use...

Methods and compositions for producing an adenovirus vector for use...

Breast cancer vaccines and methods of use thereof

HPV vaccines and methods of use thereof

Methods and compositions for combination immunotherapy

Sequential administration of a replication defective adenovirus vec...

Adenovirus polynucleotides and polypeptides

Adenovirus polynucleotides and polypeptides

Adenovirus and uses thereof

Composition for diagnosing, preventing, or treating vascular smooth...

Vectors for expression of prostate-associated antigens

Oncolytic virus and method

Adenoviral vector vaccine

Oncolytic adenovirus encoding a B7 protein

Immunomodulatory fusion proteins

Patents Applicationslast 30 patents

MODIFIED ADENOVIRUSES

IMMUNOMODULATORY FUSION PROTEINS

ADENOVIRAL VECTOR SYSTEM FOR GENE DELIVERY

ONCOLYTIC ADENOVIRUSES FOR TREATING CANCER

VECTOR FOR CANCER TREATMENT

COMPOSITIONS, KITS AND METHODS FOR TREATMENT OF COMPLEMENT-RELATED...

VIRUS

IMMUNOGENIC COMPOSITIONS AND USES THEREOF

IMMUNOGENIC COMPOSITIONS AND USES THEREOF

METHODS AND COMPOSITIONS FOR PRODUCING AN ADENOVIRUS VECTOR FOR USE...

USE OF ONCOLYTIC ADENOVIRUS FOR THE TREATMENT OF PEDIATRIC BRAIN CA...

COVALENTLY-MODIFIED STEROID ACID-PEPTIDES HAVING ENHANCED STABILITY...

GORILLA ADENOVIRUS NUCLEIC ACID- AND AMINO ACID-SEQUENCES, VECTORS...

METHODS AND COMPOSITIONS FOR PRODUCING AN ADENOVIRUS VECTOR FOR USE...

MESENCHYMAL STEM CELLS THAT ENABLE TUMOR TARGETING IMPROVEMENT AND...

VECTOR FOR CANCER TREATMENT

METHODS AND COMPOSITIONS FOR PRODUCING AN ADENOVIRUS VECTOR FOR USE...

VISMODEGIB IN COMBINATION WITH A REPLICATION-DEFICIENT TYPE 5 ADENO...

METHODS AND COMPOSITIONS FOR PRODUCING AN ADENOVIRUS VECTOR FOR USE...

ADENOVIRAL- BASED BIOLOGICAL DELIVERY AND EXPRESSION SYSTEM FOR USE...

AD36E4ORF1: A THERAPEUTIC TREATMENT FOR ALZHEIMER'S DISEASE

METHODS AND COMPOSITIONS FOR PRODUCING AN ADENOVIRUS VECTOR FOR USE...

AGENT FOR INDUCING SPECIFIC IMMUNITY AGAINST SEVERE ACUTE RESPIRATO...

PHARMACEUTICAL AGENT FOR INDUCING SPECIFIC IMMUNITY AGAINST SARS-COV-2

MODIFIED ADENOVIRUSES

ADENOVIRAL-BASED BIOLOGICAL DELIVERY AND EXPRESSION SYSTEM FOR USE...

NOVEL APPLICATION OF HEPARIN-BINDING EPIDERMAL GROWTH FACTOR-LIKE G...

MAJOR HISTOCOMPATIBILITY COMPLEX (MHC) COMPOSITIONS AND METHODS OF...

ONCOLYTIC ADENOVIRUS COMPOSITIONS WITH ENHANCED REPLICATION PROPERTIES

MODIFIED ONCOLYTIC ADENOVIRUSES