DNAzymes

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CPC
C12N2310/127

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CCHEMISTRY METALLURGY C12Biochemistry C12NMICRO-ORGANISMS OR ENZYMES COMPOSITIONS THEREOF PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS MUTATION OR GENETIC ENGINEERING CULTURE MEDIA C12N2310/00Structure or type of the nucleic acid

Current Industry

C12N2310/127DNAzymes

Industries

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Patents Grantslast 30 patents

Information Patent Grant
Peptide docking vehicle for targeted nucleic acid delivery
- Patent number 12,054,714
- Issue date Aug 6, 2024
- Sirnaomics, Inc.
- Xiaoyong Lu
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Composition for regulating expression of PROX1 or expression of tel...
- Patent number 12,006,498
- Issue date Jun 11, 2024
- Korea Institute of Science and Technology
- Sang Hoon Jung
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Euglobulin-based method for determining the biological activity of...
- Patent number 11,746,348
- Issue date Sep 5, 2023
- GENTIUM S.R.L.
- Terenzio Ignoni
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Method for selective translation of desired proteins in the presenc...
- Patent number 11,629,366
- Issue date Apr 18, 2023
- Collin Frank Marino
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Molecular programming tools
- Patent number 11,286,517
- Issue date Mar 29, 2022
- President and Fellows of Harvard College
- Jocelyn Yoshiko Kishi
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Euglobulin-based method for determining the biological activity of...
- Patent number 11,236,328
- Issue date Feb 1, 2022
- GENTIUM S.R.L.
- Terenzio Ignoni
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Phosphorothioate DNAzyme complexes and use thereof
- Patent number 11,142,544
- Issue date Oct 12, 2021
- Juewen Liu
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Particles coated with catalysts useful for splicing nucleic acids
- Patent number 11,136,595
- Issue date Oct 5, 2021
- Emory University
- Khalid Salaita
- B82 - NANO-TECHNOLOGY
Information Patent Grant
Euglobulin-based method for determining the biological activity of...
- Patent number 11,085,043
- Issue date Aug 10, 2021
- GENTIUM S.R.L.
- Terenzio Ignoni
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
MicroRNA initiated DNAzyme motor operating in living cells
- Patent number 10,934,162
- Issue date Mar 2, 2021
- The Governors of the University of Alberta
- X. Chris Le
- B82 - NANO-TECHNOLOGY
Information Patent Grant
Approach for treating inflammatory disorders
- Patent number 10,647,987
- Issue date May 12, 2020
- Secama Pharmaceuticals GmbH & Co KG
- Frank Jaschinski
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Method for diagnosing a molecular phenotype of a patient suffering...
- Patent number 10,591,489
- Issue date Mar 17, 2020
- Sterna Biologicals GmbH & Co. KG
- Agnieszka Turowska
- G01 - MEASURING TESTING
Information Patent Grant
GATA-3 inhibitors for use in the treatment of Th2-driven asthma
- Patent number 10,487,325
- Issue date Nov 26, 2019
- Sterna Biologicals GmbH & Co. KG
- Joachim Bille
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
DNAzyme-nanoparticle conjugates and methods of use thereof
- Patent number 10,287,578
- Issue date May 14, 2019
- The University of Notre Dame
- James Carter
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Particle-nucleic acid conjugates and therapeutic uses related thereto
- Patent number 10,155,946
- Issue date Dec 18, 2018
- Emory University
- Kevin Yehl
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Method for evaluating redox activity of nucleic acid molecule and n...
- Patent number 10,138,480
- Issue date Nov 27, 2018
- NEC SOLUTION INNOVATORS, LTD.
- Naoto Kaneko
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Fluorescence sensor for target analysis, kit for target analysis, a...
- Patent number 10,012,631
- Issue date Jul 3, 2018
- NEC SOLUTION INNOVATORS, LTD.
- Naoto Kaneko
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Euglobulin-based method for determining the biological activity of...
- Patent number 9,902,952
- Issue date Feb 27, 2018
- GENTRUM S.R.L.
- Terenzio Ignoni
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Dnazyme for silencing the expression of EGFR
- Patent number 9,856,480
- Issue date Jan 2, 2018
- NATIONAL TAIWAN UNIVERSITY
- Pan-Chyr Yang
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Particle-nucleic acid conjugates and therapeutic uses related thereto
- Patent number 9,803,197
- Issue date Oct 31, 2017
- Emory University
- Kevin Yehl
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Method for diagnosing a molecular phenotype of a patient suffering...
- Patent number 9,791,454
- Issue date Oct 17, 2017
- Sterna Biologicals GmbH & Co. KG
- Agnieszka Turowska
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Method for evaluating redox activity of nucleic acid molecule and n...
- Patent number 9,637,737
- Issue date May 2, 2017
- NEC SOLUTION INNOVATORS, LTD.
- Naoto Kaneko
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Catalytic nucleic acid probes as microbial indicators
- Patent number 9,624,551
- Issue date Apr 18, 2017
- McMaster University
- Yingfu Li
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
cDNA construct of Salmonidae alphavirus
- Patent number 9,611,300
- Issue date Apr 4, 2017
- Institut National de la Recherche Agronomique
- Monique Leberre
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Dermatological, pharmaceutical composition suitable for oligonucleo...
- Patent number 9,404,110
- Issue date Aug 2, 2016
- Sterna Biologicals GmbH & Co. KG
- Thomas Schmidts
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Dermatological, pharmaceutical composition suitable for oligonucleo...
- Patent number 9,249,413
- Issue date Feb 2, 2016
- Sterna Biologicals GmbH & Co. KG
- Thomas Schmidts
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Nucleic acid enzymes and complexes and methods for their use
- Patent number 8,962,238
- Issue date Feb 24, 2015
- SpeedDx Pty Ltd
- Alison Velyian Todd
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Nanoparticle-based gene delivery systems
- Patent number 8,871,509
- Issue date Oct 28, 2014
- Chung-Ang University-Academy Corporation Foundation
- Min Su Han
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Use of DNAzymes for analysis of an RNA sample
- Patent number 8,815,782
- Issue date Aug 26, 2014
- Agilent Technologies, Inc.
- Gusti Zeiner
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
cDNA construct of salmonidae alphavirus
- Patent number 8,603,491
- Issue date Dec 10, 2013
- Institut National de la Recherche Agronomique
- Monique Leberre
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE

Patents Applicationslast 30 patents

Information Patent Application
BIOLOGICALLY STABLE XNAZYME THAT EFFICIENTLY SILENCES GENE EXPRESSI...
- Publication number 20240392298
- Publication date Nov 28, 2024
- The Regents of the University of California
- John C. Chaput
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
DNAZYME HYDROGEL FORMULATIONS
- Publication number 20240382430
- Publication date Nov 21, 2024
- Sterna Biologicals GmbH
- Thomas Rupp
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
GUANINE-RICH DEOXYRIBOZYMES, COMPOSITIONS AND USES THEREOF
- Publication number 20240344064
- Publication date Oct 17, 2024
- 1E Therapeutics, Ltd.
- Ido BACHELET
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
DNAZYMES TARGETING CELL WALL SYNTHESIS ENZYMES AND USES THEREOF
- Publication number 20240336923
- Publication date Oct 10, 2024
- 1E Therapeutics, Ltd.
- Ido BACHELET
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
OPTICAL TRANSMISSION SAMPLE HOLDER AND ANALYSIS, PARTICULARLY FOR H...
- Publication number 20240309369
- Publication date Sep 19, 2024
- ESSENLIX CORPORATION
- Stephen Y. CHOU
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Deoxyribozymes Generating Chemiluminescent Signals
- Publication number 20240229108
- Publication date Jul 11, 2024
- USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I.
- Edward Arthur CURTIS
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
MULTICOMPONENT XNAZYME-BASED NUCLEIC ACID DETECTION SYSTEM
- Publication number 20240209333
- Publication date Jun 27, 2024
- The Regents of the University of California
- John Chaput
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Deoxyribozymes Generating Chemiluminescent Signals
- Publication number 20240132941
- Publication date Apr 25, 2024
- USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I.
- Edward Arthur CURTIS
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
P21 MRNA TARGETING DNAZYMES
- Publication number 20240076671
- Publication date Mar 7, 2024
- Rehovot
- NOAM PILPEL
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
COMPOSITION FOR TREATING A PATIENT SUFFERING FROM ULCERATIVE COLITI...
- Publication number 20240041912
- Publication date Feb 8, 2024
- STERNA BIOLOGICALS GMBH & CO. KG
- Jonas Renz
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
METHODS OF GENE ASSEMBLY USING DNAZYMES AND USE IN DNA DATA STORAGE
- Publication number 20240035018
- Publication date Feb 1, 2024
- Gemma Roselle MENDONSA
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
EUGLOBULIN-BASED METHOD FOR DETERMINING THE BIOLOGICAL ACTIVITY OF...
- Publication number 20230357762
- Publication date Nov 9, 2023
- GENTIUM S.R.L.
- Terenzio IGNONI
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
METHODS OF TREATING AND PREVENTING BACTERIAL INFECTIONS
- Publication number 20230265424
- Publication date Aug 24, 2023
- 1E Therapeutics Ltd.
- IDO BACHELET
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
TARGETING ZNF410 FOR FETAL HEMOGLOBIN INDUCTION IN BETAHEMOGLOBINOP...
- Publication number 20230257746
- Publication date Aug 17, 2023
- The Children's Medical Center Corporation
- Daniel E. BAUER
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
COMPOSITION FOR REGULATING EXPRESSION OF PROX1 OR EXPRESSION OF TEL...
- Publication number 20230250424
- Publication date Aug 10, 2023
- Korea Institute of Science and Technology
- Sang Hoon JUNG
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
ENGINEERED NUCLEIC ACIDS AND USES THEREOF
- Publication number 20230174982
- Publication date Jun 8, 2023
- The Methodist Hospital System
- Nan ZHANG
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
RESPONSIVE, CATALYTIC NUCLEIC NANOSTRUCTURES
- Publication number 20230159990
- Publication date May 25, 2023
- National University of Singapore
- Huilin Shao
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
PHARMACEUTICAL COMPOSITION CONTAINING HERES EXPRESSION INHIBITOR FO...
- Publication number 20220348927
- Publication date Nov 3, 2022
- IUCF-HYU(Industry-University Cooperation Foundation Hanyang University)
- Jin-Wu NAM
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
MOLECULAR PROGRAMMING TOOLS
- Publication number 20220348990
- Publication date Nov 3, 2022
- President and Fellows of Harvard College
- Jocelyn Yoshiko Kishi
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Method for the production of a catalytically active DNA molecule ha...
- Publication number 20220340904
- Publication date Oct 27, 2022
- Sterna Biologicals GmbH
- Thomas RUPP
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Tumor-Targeting Polypeptide Nanoparticle Delivery System for Nuclei...
- Publication number 20220331441
- Publication date Oct 20, 2022
- Sirnaomics, Inc.
- Xiaoyong LU
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
DNAZYMES FOR DETECTING LEGIONELLA PNEUMOPHILA
- Publication number 20220317123
- Publication date Oct 6, 2022
- McMaster University
- Yingfu Li
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
ENZYMATIC NUCLEIC ACID MOLECULES
- Publication number 20210395753
- Publication date Dec 23, 2021
- Greg BROOKE
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
EUGLOBULIN-BASED METHOD FOR DETERMINING THE BIOLOGICAL ACTIVITY OF...
- Publication number 20210388350
- Publication date Dec 16, 2021
- GENTIUM S.R.L.
- Terenzio IGNONI
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
EUGLOBULIN-BASED METHOD FOR DETERMINING THE BIOLOGICAL ACTIVITY OF...
- Publication number 20210363519
- Publication date Nov 25, 2021
- GENTIUM S.R.L.
- Terenzio IGNONI
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
METHOD OF TREATING WASTING DISORDERS
- Publication number 20210269517
- Publication date Sep 2, 2021
- CSL Limited
- Ulf ERIKSSON
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
Peptide Docking Vehicle for Targeted Nucleic Acid Delivery
- Publication number 20210214726
- Publication date Jul 15, 2021
- Sirnaomics, Inc.
- Xiaoyong LU
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
COMPOSITION FOR TREATING A PATIENT SUFFERING FROM ULCERATIVE COLITI...
- Publication number 20210177883
- Publication date Jun 17, 2021
- STERNA BIOLOGICALS GMBH & CO. KG
- Jonas Renz
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
EMBRYONIC ZEBRAFISH MODELS USING DNAZYME MEDIATED KNOCKDOWN
- Publication number 20210022324
- Publication date Jan 28, 2021
- DR. REDDY'S INSTITUTE OF LIFE SCIENCES
- Aarti SEVILIMEDU
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
METHODS AND COMPOSITIONS FOR GENERATING DOMINANT ALLELES USING GENO...
- Publication number 20200377900
- Publication date Dec 3, 2020
- Monsanto Technology LLC
- Edward James CARGILL
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...

Industry

Parent Industries

Current Industry

Patents Grantslast 30 patents

Peptide docking vehicle for targeted nucleic acid delivery

Composition for regulating expression of PROX1 or expression of tel...

Euglobulin-based method for determining the biological activity of...

Method for selective translation of desired proteins in the presenc...

Molecular programming tools

Euglobulin-based method for determining the biological activity of...

Phosphorothioate DNAzyme complexes and use thereof

Particles coated with catalysts useful for splicing nucleic acids

Euglobulin-based method for determining the biological activity of...

MicroRNA initiated DNAzyme motor operating in living cells

Approach for treating inflammatory disorders

Method for diagnosing a molecular phenotype of a patient suffering...

GATA-3 inhibitors for use in the treatment of Th2-driven asthma

DNAzyme-nanoparticle conjugates and methods of use thereof

Particle-nucleic acid conjugates and therapeutic uses related thereto

Method for evaluating redox activity of nucleic acid molecule and n...

Fluorescence sensor for target analysis, kit for target analysis, a...

Euglobulin-based method for determining the biological activity of...

Dnazyme for silencing the expression of EGFR

Particle-nucleic acid conjugates and therapeutic uses related thereto

Method for diagnosing a molecular phenotype of a patient suffering...

Method for evaluating redox activity of nucleic acid molecule and n...

Catalytic nucleic acid probes as microbial indicators

cDNA construct of Salmonidae alphavirus

Dermatological, pharmaceutical composition suitable for oligonucleo...

Dermatological, pharmaceutical composition suitable for oligonucleo...

Nucleic acid enzymes and complexes and methods for their use

Nanoparticle-based gene delivery systems

Use of DNAzymes for analysis of an RNA sample

cDNA construct of salmonidae alphavirus

Patents Applicationslast 30 patents

BIOLOGICALLY STABLE XNAZYME THAT EFFICIENTLY SILENCES GENE EXPRESSI...

DNAZYME HYDROGEL FORMULATIONS

GUANINE-RICH DEOXYRIBOZYMES, COMPOSITIONS AND USES THEREOF

DNAZYMES TARGETING CELL WALL SYNTHESIS ENZYMES AND USES THEREOF

OPTICAL TRANSMISSION SAMPLE HOLDER AND ANALYSIS, PARTICULARLY FOR H...

Deoxyribozymes Generating Chemiluminescent Signals

MULTICOMPONENT XNAZYME-BASED NUCLEIC ACID DETECTION SYSTEM

Deoxyribozymes Generating Chemiluminescent Signals

P21 MRNA TARGETING DNAZYMES

COMPOSITION FOR TREATING A PATIENT SUFFERING FROM ULCERATIVE COLITI...

METHODS OF GENE ASSEMBLY USING DNAZYMES AND USE IN DNA DATA STORAGE

EUGLOBULIN-BASED METHOD FOR DETERMINING THE BIOLOGICAL ACTIVITY OF...

METHODS OF TREATING AND PREVENTING BACTERIAL INFECTIONS

TARGETING ZNF410 FOR FETAL HEMOGLOBIN INDUCTION IN BETAHEMOGLOBINOP...

COMPOSITION FOR REGULATING EXPRESSION OF PROX1 OR EXPRESSION OF TEL...

ENGINEERED NUCLEIC ACIDS AND USES THEREOF

RESPONSIVE, CATALYTIC NUCLEIC NANOSTRUCTURES

PHARMACEUTICAL COMPOSITION CONTAINING HERES EXPRESSION INHIBITOR FO...

MOLECULAR PROGRAMMING TOOLS

Method for the production of a catalytically active DNA molecule ha...

Tumor-Targeting Polypeptide Nanoparticle Delivery System for Nuclei...

DNAZYMES FOR DETECTING LEGIONELLA PNEUMOPHILA

ENZYMATIC NUCLEIC ACID MOLECULES

EUGLOBULIN-BASED METHOD FOR DETERMINING THE BIOLOGICAL ACTIVITY OF...

EUGLOBULIN-BASED METHOD FOR DETERMINING THE BIOLOGICAL ACTIVITY OF...

METHOD OF TREATING WASTING DISORDERS

Peptide Docking Vehicle for Targeted Nucleic Acid Delivery

COMPOSITION FOR TREATING A PATIENT SUFFERING FROM ULCERATIVE COLITI...

EMBRYONIC ZEBRAFISH MODELS USING DNAZYME MEDIATED KNOCKDOWN

METHODS AND COMPOSITIONS FOR GENERATING DOMINANT ALLELES USING GENO...