Immunoglobulins having two or more different antigen binding sites

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C07K16/468

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CCHEMISTRY METALLURGY C07Organic chemistry C07KPEPTIDES C07K16/00Immunoglobulins [IGs]

Current Industry

C07K16/468Immunoglobulins having two or more different antigen binding sites

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Patents Grantslast 30 patents

Information Patent Grant
Heterodimeric antibodies that bind CD3 and tumor antigens
- Patent number 12,359,002
- Issue date Jul 15, 2025
- Xencor, Inc.
- Matthew Bernett
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Bispecific anti-human A-beta/anti-human transferrin receptor antibo...
- Patent number 12,358,997
- Issue date Jul 15, 2025
- HOFFMANN-LA ROCHE INC.
- Harald Duerr
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Method for producing polypeptide hetero-oligomer
- Patent number 12,359,001
- Issue date Jul 15, 2025
- CHUGAI SEIYAKU KABUSHIKI KAISHA
- Tomoyuki Igawa
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
PD1 and/or LAG3 binders
- Patent number 12,351,630
- Issue date Jul 8, 2025
- Merck Sharp & Dohme LLC
- Edward Bowman
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Antibodies binding to fibroblast activation protein alpha and death...
- Patent number 12,351,650
- Issue date Jul 8, 2025
- GENMAB A/S
- Bart E.C.G. De Goeij
- G01 - MEASURING TESTING
Information Patent Grant
Bispecific antibody
- Patent number 12,344,674
- Issue date Jul 1, 2025
- Mie University
- Hiroshi Shiku
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
CH3 domain variant pair inducing formation of heterodimer of heavy...
- Patent number 12,344,679
- Issue date Jul 1, 2025
- AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
- Yong Sung Kim
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
CD47-CD38 bispecific antibodies
- Patent number 12,338,292
- Issue date Jun 24, 2025
- IGI Therapeutics SA
- Laure Bouchez
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Efflux pump-cancer antigen multi-specific antibodies and compositio...
- Patent number 12,331,121
- Issue date Jun 17, 2025
- William Robert Arathoon Living Trust Dated August 29, 2016
- William Robert Arathoon
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Protease cleavable bispecific antibodies and uses thereof
- Patent number 12,325,757
- Issue date Jun 10, 2025
- Zhejiang Shimai Pharmaceutical Co., Ltd.
- Weizao Chen
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Anti-TNFα/anti IL-17A natural antibody structure-like heterodimer f...
- Patent number 12,325,743
- Issue date Jun 10, 2025
- Beijing Hanmi Pharmaceutical Co., Ltd.
- Jiawang Liu
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Protease cleavable bispecific antibodies and uses thereof
- Patent number 12,325,758
- Issue date Jun 10, 2025
- Zhejiang Shimai Pharmaceutical Co., Ltd.
- Weizao Chen
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Compositions and methods for making antibody conjugates
- Patent number 12,324,842
- Issue date Jun 10, 2025
- The Trustees of the University of Pennsylvania
- Andrew Tsourkas
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Anti-VEGF-anti-PD-L1 bispecific antibody, pharmaceutical compositio...
- Patent number 12,325,759
- Issue date Jun 10, 2025
- BIOTHEUS INC.
- Xiaoniu Miao
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Orthogonal mutations for heterodimerization
- Patent number 12,312,418
- Issue date May 27, 2025
- INVENRA INC.
- Jonathan Harry Davis
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Compositions and methods related to engineered Fc constructs
- Patent number 12,297,291
- Issue date May 13, 2025
- Momenta Pharmaceuticals, Inc.
- Carlos J. Bosques
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Bispecific antigen-binding molecules and methods of use
- Patent number 12,297,270
- Issue date May 13, 2025
- Genentech, Inc.
- Diego Ellerman
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Multispecific antigen-binding molecules and uses thereof
- Patent number 12,297,257
- Issue date May 13, 2025
- REGENERON PHARMACEUTICALS, INC.
- Julian Andreev
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Wnt surrogate molecules and uses thereof
- Patent number 12,297,278
- Issue date May 13, 2025
- Surrozen Operating, Inc.
- Yang Li
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Antibody constructs for CDH19 and CD3
- Patent number 12,297,292
- Issue date May 13, 2025
- Amgen Inc.
- Shouhua Xiao
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Generation of binding molecules
- Patent number 12,291,798
- Issue date May 6, 2025
- Merus N.V.
- Mark Throsby
- C40 - COMBINATORIAL CHEMISTRY
Information Patent Grant
IL12 receptor synthetic cytokines and methods of use
- Patent number 12,291,572
- Issue date May 6, 2025
- Synthekine, Inc.
- Robert Kastelein
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Modified antigen binding polypeptide constructs and uses thereof
- Patent number 12,286,489
- Issue date Apr 29, 2025
- Zymeworks BC, Inc.
- Mario Sanches
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
IL10RB binding molecules and encoding nucleic acids
- Patent number 12,286,482
- Issue date Apr 29, 2025
- Synthekine, Inc.
- Robert Kastelein
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Binding molecules for BCMA and CD3
- Patent number 12,281,175
- Issue date Apr 22, 2025
- Amgen Inc.
- Peter Kufer
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Binding molecules for BCMA and CD3
- Patent number 12,281,176
- Issue date Apr 22, 2025
- Amgen Inc.
- Peter Kufer
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Heterodimer molecule based on CH3 domain, and preparation method an...
- Patent number 12,281,177
- Issue date Apr 22, 2025
- JIANGSU ALPHAMAB BIOPHARMACEUTICALS CO., LTD.
- Ting Xu
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Binding molecules against BCMA and uses thereof
- Patent number 12,275,795
- Issue date Apr 15, 2025
- Novartis AG
- Aida Abujoub
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Human antibodies to the human glucagon receptor (HGCGR) and methods...
- Patent number 12,269,889
- Issue date Apr 8, 2025
- REGENERON PHARMACEUTICALS, INC.
- Haruka Okamoto
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Antigen binding proteins specifically binding MAGE-A
- Patent number 12,269,881
- Issue date Apr 8, 2025
- Immatics Biotechnologies GmbH
- Meike Hutt
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE

Patents Applicationslast 30 patents

Information Patent Application
GENERATION OF BINDING MOLECULES
- Publication number 20250230579
- Publication date Jul 17, 2025
- Merus N.V.
- Mark THROSBY
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
HETERODIMERIC HUMAN IgG1 POLYPEPTIDES WITH ISOELECTRIC POINT MODIFI...
- Publication number 20250230262
- Publication date Jul 17, 2025
- Xencor, Inc.
- Gregory L. Moore
- C07 - ORGANIC CHEMISTRY
Information Patent Application
METHODS AND AGENTS FOR THE TREATMENT OF OCULAR DISEASE
- Publication number 20250230228
- Publication date Jul 17, 2025
- Line 6 Biotechnology, Inc.
- Brian W. ZIEGELAAR
- C07 - ORGANIC CHEMISTRY
Information Patent Application
BISPECIFIC ANTI-HUMAN A-BETA/HUMAN TRANSFERRIN RECEPTOR ANTIBODIES...
- Publication number 20250223372
- Publication date Jul 10, 2025
- HOFFMANN-LA ROCHE INC.
- Harald Duerr
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
WNT SURROGATE MOLECULES AND USES THEREOF
- Publication number 20250223368
- Publication date Jul 10, 2025
- Surrozen Operating, Inc.
- Yang LI
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
MODIFIED ANTIGEN BINDINGPOLYPEPTIDE CONSTRUCTS AND USES THEREOF
- Publication number 20250215115
- Publication date Jul 3, 2025
- ZYMEWORKS BC INC.
- Mario Sanches
- C07 - ORGANIC CHEMISTRY
Information Patent Application
NEUTRALIZING ANTIBODIES TO GP120 AND THEIR USE
- Publication number 20250215068
- Publication date Jul 3, 2025
- The U.S.A as represented by the Secretary, Department of Health and Human Ser...
- Mark Connors
- G01 - MEASURING TESTING
Information Patent Application
Use of Car and Bite Technology Coupled with an SCFV from an Antibod...
- Publication number 20250215075
- Publication date Jul 3, 2025
- Kim Leslie O'Neill
- C07 - ORGANIC CHEMISTRY
Information Patent Application
ANTIGEN BINDING PROTEINS SPECIFICALLY BINDING MAGE-A
- Publication number 20250215084
- Publication date Jul 3, 2025
- Immatics Biotechnologies GmbH
- Meike HUTT
- C07 - ORGANIC CHEMISTRY
Information Patent Application
METHODS OF DEPLETING DISEASE CAUSING AGENTS VIA ANTIBODY TARGETED P...
- Publication number 20250206826
- Publication date Jun 26, 2025
- Dren Bio, Inc.
- Panagiotis FOTAKIS
- C07 - ORGANIC CHEMISTRY
Information Patent Application
METHOD FOR IN VIVO GENERATION OF MULTISPECIFIC ANTIBODIES FROM MONO...
- Publication number 20250206821
- Publication date Jun 26, 2025
- HOFFMANN-LA ROCHE INC.
- Ulrich Brinkmann
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
DIMERIC ANTIBODIES AND THEIR METHODS OF MANUFACTURE
- Publication number 20250206847
- Publication date Jun 26, 2025
- Medicovestor, Inc.
- Seah Lim
- C07 - ORGANIC CHEMISTRY
Information Patent Application
BISPECIFIC ANTIBODIES WITH CLEAVABLE C-TERMINAL CHARGE-PAIRED TAGS
- Publication number 20250197518
- Publication date Jun 19, 2025
- Amgen Inc.
- John K. KAWOOYA
- C07 - ORGANIC CHEMISTRY
Information Patent Application
TRISPECIFIC BINDING PROTEINS AND METHODS OF USE
- Publication number 20250197526
- Publication date Jun 19, 2025
- Harpoon Therapeutics, Inc.
- Patrick BAEUERLE
- C07 - ORGANIC CHEMISTRY
Information Patent Application
STABLE HETERODIMERIC ANTIBODY DESIGN WITH MUTATIONS IN THE Fc DOMAIN
- Publication number 20250197527
- Publication date Jun 19, 2025
- ZYMEWORKS BC INC.
- Thomas Spreter Von Kreudenstein
- C07 - ORGANIC CHEMISTRY
Information Patent Application
Anti-FLT3 Antigen Binding Proteins
- Publication number 20250197510
- Publication date Jun 19, 2025
- Deutsches Krebsforschungszentrum Stiftung des Offentlichen Rechts
- Gundram Jung
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
NATURAL KILLER (NK) CELL ENGAGERS BINDING TO NKp46 AND BCMA VARIANT...
- Publication number 20250197528
- Publication date Jun 19, 2025
- SANOFI
- Nicolas GOURDIN
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
NEUTRALIZING ANTIBODIES TO GP120 AND THEIR USE
- Publication number 20250179154
- Publication date Jun 5, 2025
- The U.S.A as represented by the Secretary, Department of Health and Human Ser...
- Mark Connors
- G01 - MEASURING TESTING
Information Patent Application
COMPOSITIONS AND METHODS RELATED TO IL27 RECEPTOR BINDING
- Publication number 20250179198
- Publication date Jun 5, 2025
- Synthekine, Inc.
- Robert Kastelein
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
MULTISPECIFIC ANTIGEN-BINDING PROTEINS
- Publication number 20250177523
- Publication date Jun 5, 2025
- Genentech, Inc.
- Paul CARTER
- G01 - MEASURING TESTING
Information Patent Application
IL27RAlpha BINDING MOLECULES AND METHODS OF USE
- Publication number 20250171548
- Publication date May 29, 2025
- Synthekine, Inc.
- Robert Kastelein
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
BISPECIFIC T CELL ENGAGING ANTIBODY CONSTRUCTS
- Publication number 20250163177
- Publication date May 22, 2025
- AMGEN RESEARCH (MUNICH) GMBH
- Tobias Raum
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
PROTEINS COMPRISING CD3 ANTIGEN BINDING DOMAINS AND USES THEREOF
- Publication number 20250145711
- Publication date May 8, 2025
- JANSSEN BIOTECH, INC.
- Adam Zwolak
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
ANTI-PD-L1/ANTI-4-1BB BISPECIFIC ANTIBODIES AND USES THEREOF
- Publication number 20250145718
- Publication date May 8, 2025
- ABL Bio Inc.
- Eunyoung PARK
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
ADAM9-Binding Molecules, and Methods of Use Thereof
- Publication number 20250115676
- Publication date Apr 10, 2025
- MacroGenics, Inc.
- Deryk T. Loo
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
DUAL SPECIFIC ANTIBODIES
- Publication number 20250109195
- Publication date Apr 3, 2025
- Genentech, Inc.
- Germaine FUH
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
HETERODIMERIC ANTIBODIES THAT BIND CD3 AND TUMOR ANTIGENS
- Publication number 20250109215
- Publication date Apr 3, 2025
- Xencor, Inc.
- Matthew J. Bernett
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
COMPOSITIONS AND METHODS FOR CROSSLINKING FC RECEPTORS
- Publication number 20250109216
- Publication date Apr 3, 2025
- The University of North Carolina at Chapel Hill
- Barbara Vilen
- C07 - ORGANIC CHEMISTRY
Information Patent Application
METHODS, COMPOSITIONS AND KITS FOR TREATING A SUBJECT USING A RECOM...
- Publication number 20250101137
- Publication date Mar 27, 2025
- Trustees of Tufts College
- CHARLES B. SHOEMAKER
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
T CELL ENGAGERS
- Publication number 20250092160
- Publication date Mar 20, 2025
- Biomolecular Holdings LLC
- Daniel J. Capon
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE

Immunoglobulins having two or more different antigen binding sites

Industry

Parent Industries

Current Industry

Patents Grantslast 30 patents

Heterodimeric antibodies that bind CD3 and tumor antigens

Bispecific anti-human A-beta/anti-human transferrin receptor antibo...

Method for producing polypeptide hetero-oligomer

PD1 and/or LAG3 binders

Antibodies binding to fibroblast activation protein alpha and death...

Bispecific antibody

CH3 domain variant pair inducing formation of heterodimer of heavy...

CD47-CD38 bispecific antibodies

Efflux pump-cancer antigen multi-specific antibodies and compositio...

Protease cleavable bispecific antibodies and uses thereof

Anti-TNFα/anti IL-17A natural antibody structure-like heterodimer f...

Protease cleavable bispecific antibodies and uses thereof

Compositions and methods for making antibody conjugates

Anti-VEGF-anti-PD-L1 bispecific antibody, pharmaceutical compositio...

Orthogonal mutations for heterodimerization

Compositions and methods related to engineered Fc constructs

Bispecific antigen-binding molecules and methods of use

Multispecific antigen-binding molecules and uses thereof

Wnt surrogate molecules and uses thereof

Antibody constructs for CDH19 and CD3

Generation of binding molecules

IL12 receptor synthetic cytokines and methods of use

Modified antigen binding polypeptide constructs and uses thereof

IL10RB binding molecules and encoding nucleic acids

Binding molecules for BCMA and CD3

Binding molecules for BCMA and CD3

Heterodimer molecule based on CH3 domain, and preparation method an...

Binding molecules against BCMA and uses thereof

Human antibodies to the human glucagon receptor (HGCGR) and methods...

Antigen binding proteins specifically binding MAGE-A

Patents Applicationslast 30 patents

GENERATION OF BINDING MOLECULES

HETERODIMERIC HUMAN IgG1 POLYPEPTIDES WITH ISOELECTRIC POINT MODIFI...

METHODS AND AGENTS FOR THE TREATMENT OF OCULAR DISEASE

BISPECIFIC ANTI-HUMAN A-BETA/HUMAN TRANSFERRIN RECEPTOR ANTIBODIES...

WNT SURROGATE MOLECULES AND USES THEREOF

MODIFIED ANTIGEN BINDINGPOLYPEPTIDE CONSTRUCTS AND USES THEREOF

NEUTRALIZING ANTIBODIES TO GP120 AND THEIR USE

Use of Car and Bite Technology Coupled with an SCFV from an Antibod...

ANTIGEN BINDING PROTEINS SPECIFICALLY BINDING MAGE-A

METHODS OF DEPLETING DISEASE CAUSING AGENTS VIA ANTIBODY TARGETED P...

METHOD FOR IN VIVO GENERATION OF MULTISPECIFIC ANTIBODIES FROM MONO...

DIMERIC ANTIBODIES AND THEIR METHODS OF MANUFACTURE

BISPECIFIC ANTIBODIES WITH CLEAVABLE C-TERMINAL CHARGE-PAIRED TAGS

TRISPECIFIC BINDING PROTEINS AND METHODS OF USE

STABLE HETERODIMERIC ANTIBODY DESIGN WITH MUTATIONS IN THE Fc DOMAIN

Anti-FLT3 Antigen Binding Proteins

NATURAL KILLER (NK) CELL ENGAGERS BINDING TO NKp46 AND BCMA VARIANT...

NEUTRALIZING ANTIBODIES TO GP120 AND THEIR USE

COMPOSITIONS AND METHODS RELATED TO IL27 RECEPTOR BINDING

MULTISPECIFIC ANTIGEN-BINDING PROTEINS

IL27RAlpha BINDING MOLECULES AND METHODS OF USE

BISPECIFIC T CELL ENGAGING ANTIBODY CONSTRUCTS

PROTEINS COMPRISING CD3 ANTIGEN BINDING DOMAINS AND USES THEREOF

ANTI-PD-L1/ANTI-4-1BB BISPECIFIC ANTIBODIES AND USES THEREOF

ADAM9-Binding Molecules, and Methods of Use Thereof

DUAL SPECIFIC ANTIBODIES

HETERODIMERIC ANTIBODIES THAT BIND CD3 AND TUMOR ANTIGENS

COMPOSITIONS AND METHODS FOR CROSSLINKING FC RECEPTORS

METHODS, COMPOSITIONS AND KITS FOR TREATING A SUBJECT USING A RECOM...

T CELL ENGAGERS