involving restriction enzymes

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CPC
C12Q1/683

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CCHEMISTRY METALLURGY C12Biochemistry C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS COMPOSITIONS OR TEST PAPERS THEREFOR PROCESSES OF PREPARING SUCH COMPOSITIONS CONDITION RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or micro-organisms Compositions therefor Processes of preparing such compositions

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C12Q1/683involving restriction enzymes

Industries

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Patents Grantslast 30 patents

Information Patent Grant
Systems and methods for biomolecule retention
- Patent number 12,305,167
- Issue date May 20, 2025
- Nautilus Subsidiary, Inc.
- Pengyu Hao
- B82 - NANO-TECHNOLOGY
Information Patent Grant
Single molecule analysis with high accuracy
- Patent number 12,305,232
- Issue date May 20, 2025
- Gnothis Holding AG
- Rudolf Rigler
- G01 - MEASURING TESTING
Information Patent Grant
Systems and methods for on-chip analysis of nucleic acids and for m...
- Patent number 12,303,899
- Issue date May 20, 2025
- Cornell University
- Harold G. Craighead
- B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
Information Patent Grant
Genetically modified bacteria producing three DNA repair enzymes an...
- Patent number 12,305,174
- Issue date May 20, 2025
- Universidad de la Republica
- Juan José Marizcurrena
- G01 - MEASURING TESTING
Information Patent Grant
Methods and systems for integrated on-chip single-molecule detection
- Patent number 12,306,093
- Issue date May 20, 2025
- Nautilus Subsidiary, Inc.
- Pierre Indermuhle
- G01 - MEASURING TESTING
Information Patent Grant
Modified excisable DAS68416-4 soybean transgenic herbicide resistan...
- Patent number 12,305,175
- Issue date May 20, 2025
- INARI AGRICULTURE TECHNOLOGY, INC.
- Michael Andreas Kock
- A01 - AGRICULTURE FORESTRY ANIMAL HUSBANDRY HUNTING TRAPPING FISHING
Information Patent Grant
Spatially encoded biological assays
- Patent number 12,297,488
- Issue date May 13, 2025
- Prognosys Biosciences, Inc.
- Mark S. Chee
- C40 - COMBINATORIAL CHEMISTRY
Information Patent Grant
Multicomponent nucleic acid probes for sample analysis
- Patent number 12,297,499
- Issue date May 13, 2025
- 10X GENOMICS, INC.
- Evan Daugharthy
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Spatially encoded biological assays
- Patent number 12,297,487
- Issue date May 13, 2025
- Prognosys Biosciences, Inc.
- Mark S. Chee
- C40 - COMBINATORIAL CHEMISTRY
Information Patent Grant
Methods for spatial analysis using proximity ligation
- Patent number 12,297,486
- Issue date May 13, 2025
- 10X GENOMICS, INC.
- David Michael Patterson
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Methods and/or use of oligonucleotide conjugates for assays and flo...
- Patent number 12,291,738
- Issue date May 6, 2025
- The University of Chicago
- David A. Schwartz
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Electrochemically-cleavable linkers
- Patent number 12,281,134
- Issue date Apr 22, 2025
- Microsoft Technology Licensing, LLC
- Bichlien Nguyen
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Methods for diagnosing and treating inflammatory bowel disease
- Patent number 12,281,351
- Issue date Apr 22, 2025
- Meharry Medical College
- Amosy M'Koma
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Multiplexed imaging with enzyme mediated amplification
- Patent number 12,281,355
- Issue date Apr 22, 2025
- Akoya Biosciences, Inc.
- Grady Carlson
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Chemical compositions and methods of using same
- Patent number 12,281,356
- Issue date Apr 22, 2025
- Bruker Spatial Biology, Inc.
- Dwayne Dunaway
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Method for the site-specific enzymatic labelling of nucleic acids i...
- Patent number 12,281,137
- Issue date Apr 22, 2025
- The Scripps Research Institute
- Floyd E. Romesberg
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Egg-type chicken whole-genome SNP chip and use thereof
- Patent number 12,275,987
- Issue date Apr 15, 2025
- China Agricultural University
- Ning Yang
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Nucleic acid detection method
- Patent number 12,275,991
- Issue date Apr 15, 2025
- Sense Biodetection Limited
- Henry John Lamble
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Method for identifying mastitis-causing microbes
- Patent number 12,270,076
- Issue date Apr 8, 2025
- Michael E. Hogan
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Engineered polymerases
- Patent number 12,270,056
- Issue date Apr 8, 2025
- ELEMENT BIOSCIENCES, INC.
- Mark Ambroso
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Single stranded circular DNA libraries for circular consensus seque...
- Patent number 12,270,070
- Issue date Apr 8, 2025
- Roche Sequencing Solutions, Inc.
- Rui Chen
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
CRISPR enzymes and systems
- Patent number 12,264,359
- Issue date Apr 1, 2025
- The Broad Institute, Inc.
- Feng Zhang
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Method for estimating inflammation area of periodontal pockets
- Patent number 12,258,622
- Issue date Mar 25, 2025
- GC CORPORATION
- Naoyuki Togawa
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
High-throughput method for detecting chromosomal aberrations and/or...
- Patent number 12,258,621
- Issue date Mar 25, 2025
- CELL ENVIRONMENT
- Radhia M'Kacher
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Swellable and structurally homogenous hydrogels and methods of use...
- Patent number 12,258,454
- Issue date Mar 25, 2025
- Massachusetts Institute of Technology
- Ruixuan Gao
- C08 - ORGANIC MACROMOLECULAR COMPOUNDS THEIR PREPARATION OR CHEMICAL WORKING-...
Information Patent Grant
Selectively controllable cleavable linkers
- Patent number 12,252,739
- Issue date Mar 18, 2025
- Microsoft Technology Licensing, LLC
- Karin Strauss
- B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
Information Patent Grant
Methods for fluorescence imaging microscopy and nano-fish
- Patent number 12,253,468
- Issue date Mar 18, 2025
- Altius Institute for Biomedical Sciences
- John A. Stamatoyannopoulos
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Compositions and methods for improving sample identification in ind...
- Patent number 12,247,254
- Issue date Mar 11, 2025
- Illumina, Inc.
- Eric Hans Vermaas
- C40 - COMBINATORIAL CHEMISTRY
Information Patent Grant
Method of identifying a subject having Kawasaki disease
- Patent number 12,247,256
- Issue date Mar 11, 2025
- Imperial College Innovations Limited
- Jethro Herberg
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Point of need testing device and methods of use thereof
- Patent number 12,247,250
- Issue date Mar 11, 2025
- GoDx, Inc.
- Chang Hee Kim
- B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL

Patents Applicationslast 30 patents

Information Patent Application
METHODS AND DEVICES FOR SPATIALLY ENCODED BIOLOGICAL ASSAYS
- Publication number 20250163500
- Publication date May 22, 2025
- AtlasXomics Inc.
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Methods for Multiplex Imaging Using Labeled Nucleic Acid Imaging Ag...
- Publication number 20250154559
- Publication date May 15, 2025
- Ultivue, Inc.
- Stephanie Rae HENNEK
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
METHODS FOR PERFORMING SPATIAL PROFILING OF BIOLOGICAL MOLECULES
- Publication number 20250154564
- Publication date May 15, 2025
- Centrillion Technology Holdings Corporation
- Wei Zhou
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
METHODS OF DETECTING ANALYTES
- Publication number 20250154568
- Publication date May 15, 2025
- 10x Genomics Sweden AB
- Jonas Frisen
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
DIGITAL COUNTING OF INDIVIDUAL MOLECULES BY STOCHASTIC ATTACHMENT O...
- Publication number 20250154587
- Publication date May 15, 2025
- Becton, Dickinson and Company
- Stephen P.A. Fodor
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
SPATIALLY ENCODED BIOLOGICAL ASSAYS
- Publication number 20250154565
- Publication date May 15, 2025
- Prognosys Biosciences, Inc.
- Mark S. CHEE
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
GENERATING CAPTURE PROBES FOR SPATIAL ANALYSIS
- Publication number 20250154569
- Publication date May 15, 2025
- 10X Genomics, Inc.
- Marlon Stoeckius
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
MATERIALS AND METHODS FOR LARGE-SCALE SPATIAL TRANSCRIPTOMICS
- Publication number 20250154570
- Publication date May 15, 2025
- The University of Chicago
- NICOLAS CHEVRIER
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
SPATIALLY ENCODED BIOLOGICAL ASSAYS
- Publication number 20250154566
- Publication date May 15, 2025
- Prognosys Biosciences, Inc.
- Mark S. CHEE
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
SPATIALLY ENCODED BIOLOGICAL ASSAYS
- Publication number 20250154567
- Publication date May 15, 2025
- Prognosys Biosciences, Inc.
- Mark S. CHEE
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Multiplexed Analyses of Test Samples
- Publication number 20250147022
- Publication date May 8, 2025
- SomaLogic Operating Co., Inc.
- Glenn Sanders
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
OLIGONUCLEOTIDE ASSEMBLY USING pH BASED ELECTRODE CONTROLLED HYBRID...
- Publication number 20250146053
- Publication date May 8, 2025
- Microsoft Technology Licensing, LLC
- Yuan-Jyue CHEN
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
METHOD FOR TRANSPOSASE-MEDIATED SPATIAL TAGGING AND ANALYZING GENOM...
- Publication number 20250146057
- Publication date May 8, 2025
- 10X Genomics, Inc.
- Michael Schnall-Levin
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
CELL BARCODING FOR SINGLE CELL SEQUENCING
- Publication number 20250137039
- Publication date May 1, 2025
- Bio-Rad Laboratories, Inc.
- Ronald LEBOFSKY
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
METHODS AND COMPOSITIONS FOR INTEGRATED IN SITU SPATIAL ASSAY
- Publication number 20250137040
- Publication date May 1, 2025
- 10X Genomics, Inc.
- Felice Alessio BAVA
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
METHODS, COMPOSITIONS AND SYSTEMS FOR CALIBRATING EPIGENETIC PARTIT...
- Publication number 20250137044
- Publication date May 1, 2025
- GUARDANT HEALTH, INC.
- Andrew KENNEDY
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Compositions and Methods for Analyte Detection
- Publication number 20250129408
- Publication date Apr 24, 2025
- President and Fellows of Harvard College
- Daniel Levner
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
IMAGING SYSTEM HARDWARE
- Publication number 20250129412
- Publication date Apr 24, 2025
- 10X Genomics, Inc.
- Cedric Uytingco
- B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
Information Patent Application
Compositions and Methods for Analyte Detection
- Publication number 20250122556
- Publication date Apr 17, 2025
- President and Fellows of Harvard College
- George M. Church
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
ENHANCED NUCLEIC ACID DETECTION USING CAS13 AND DESIGNED SECONDARY...
- Publication number 20250115951
- Publication date Apr 10, 2025
- The Trustees of Princeton University
- Cameron Myhrvold
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
ANALYSIS OF RNA MOLECULES USING CATALYTIC NUCLEIC ACIDS
- Publication number 20250101499
- Publication date Mar 27, 2025
- BIONTECH SE
- Irena VLATKOVIC
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
SPATIALLY ENCODED BIOLOGICAL ASSAYS
- Publication number 20250101501
- Publication date Mar 27, 2025
- Prognosys Biosciences, Inc.
- Mark S. CHEE
- C40 - COMBINATORIAL CHEMISTRY
Information Patent Application
PROCESS FOR HIGH PERFORMANCE BARCODED MAGNETIC BEADS
- Publication number 20250102500
- Publication date Mar 27, 2025
- APPLIED BIOCODE INC.
- Chung-Jen Hou
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Systems And Methods For Use In Resolving Genotypic Indicators
- Publication number 20250104807
- Publication date Mar 27, 2025
- MONSANTO TECHNOLOGY LLC
- Guilherme GOMES
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
SPATIALLY ENCODED BIOLOGICAL ASSAYS
- Publication number 20250101502
- Publication date Mar 27, 2025
- Prognosys Biosciences, Inc.
- Mark S. CHEE
- C40 - COMBINATORIAL CHEMISTRY
Information Patent Application
NOVEL PROBE SET FOR ISOTHERMAL ONE-POT REACTION, AND USES THEREOF
- Publication number 20250092451
- Publication date Mar 20, 2025
- POSTECH Research and Business Development Foundation
- Jeong Wook LEE
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
METHODS OF METHYLATION ANALYSIS FOR DISEASE DETECTION
- Publication number 20250092446
- Publication date Mar 20, 2025
- The Regents of the University of California
- Xianghong Jasmine ZHOU
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
REPORTER AND USES THEREOF
- Publication number 20250092444
- Publication date Mar 20, 2025
- SFC CO., LTD.
- Do Min LEE
- C09 - DYES PAINTS POLISHES NATURAL RESINS ADHESIVES MISCELLANEOUS COMPOSITION...
Information Patent Application
Methods of Solid-Phase Nucleic Acid Hybridization
- Publication number 20250092447
- Publication date Mar 20, 2025
- SomaLogic Operating Co., Inc.
- Bhavik Nathwani
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
MULTIPLEX AMPLIFICATION DETECTION ASSAY
- Publication number 20250084455
- Publication date Mar 13, 2025
- EXACT SCIENCES CORPORATION
- Graham P. Lidgard
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...

involving restriction enzymes

Industry

Parent Industries

Current Industry

Patents Grantslast 30 patents

Systems and methods for biomolecule retention

Single molecule analysis with high accuracy

Systems and methods for on-chip analysis of nucleic acids and for m...

Genetically modified bacteria producing three DNA repair enzymes an...

Methods and systems for integrated on-chip single-molecule detection

Modified excisable DAS68416-4 soybean transgenic herbicide resistan...

Spatially encoded biological assays

Multicomponent nucleic acid probes for sample analysis

Spatially encoded biological assays

Methods for spatial analysis using proximity ligation

Methods and/or use of oligonucleotide conjugates for assays and flo...

Electrochemically-cleavable linkers

Methods for diagnosing and treating inflammatory bowel disease

Multiplexed imaging with enzyme mediated amplification

Chemical compositions and methods of using same

Method for the site-specific enzymatic labelling of nucleic acids i...

Egg-type chicken whole-genome SNP chip and use thereof

Nucleic acid detection method

Method for identifying mastitis-causing microbes

Engineered polymerases

Single stranded circular DNA libraries for circular consensus seque...

CRISPR enzymes and systems

Method for estimating inflammation area of periodontal pockets

High-throughput method for detecting chromosomal aberrations and/or...

Swellable and structurally homogenous hydrogels and methods of use...

Selectively controllable cleavable linkers

Methods for fluorescence imaging microscopy and nano-fish

Compositions and methods for improving sample identification in ind...

Method of identifying a subject having Kawasaki disease

Point of need testing device and methods of use thereof

Patents Applicationslast 30 patents

METHODS AND DEVICES FOR SPATIALLY ENCODED BIOLOGICAL ASSAYS

Methods for Multiplex Imaging Using Labeled Nucleic Acid Imaging Ag...

METHODS FOR PERFORMING SPATIAL PROFILING OF BIOLOGICAL MOLECULES

METHODS OF DETECTING ANALYTES

DIGITAL COUNTING OF INDIVIDUAL MOLECULES BY STOCHASTIC ATTACHMENT O...

SPATIALLY ENCODED BIOLOGICAL ASSAYS

GENERATING CAPTURE PROBES FOR SPATIAL ANALYSIS

MATERIALS AND METHODS FOR LARGE-SCALE SPATIAL TRANSCRIPTOMICS

SPATIALLY ENCODED BIOLOGICAL ASSAYS

SPATIALLY ENCODED BIOLOGICAL ASSAYS

Multiplexed Analyses of Test Samples

OLIGONUCLEOTIDE ASSEMBLY USING pH BASED ELECTRODE CONTROLLED HYBRID...

METHOD FOR TRANSPOSASE-MEDIATED SPATIAL TAGGING AND ANALYZING GENOM...

CELL BARCODING FOR SINGLE CELL SEQUENCING

METHODS AND COMPOSITIONS FOR INTEGRATED IN SITU SPATIAL ASSAY

METHODS, COMPOSITIONS AND SYSTEMS FOR CALIBRATING EPIGENETIC PARTIT...

Compositions and Methods for Analyte Detection

IMAGING SYSTEM HARDWARE

Compositions and Methods for Analyte Detection

ENHANCED NUCLEIC ACID DETECTION USING CAS13 AND DESIGNED SECONDARY...

ANALYSIS OF RNA MOLECULES USING CATALYTIC NUCLEIC ACIDS

SPATIALLY ENCODED BIOLOGICAL ASSAYS

PROCESS FOR HIGH PERFORMANCE BARCODED MAGNETIC BEADS

Systems And Methods For Use In Resolving Genotypic Indicators

SPATIALLY ENCODED BIOLOGICAL ASSAYS

NOVEL PROBE SET FOR ISOTHERMAL ONE-POT REACTION, AND USES THEREOF

METHODS OF METHYLATION ANALYSIS FOR DISEASE DETECTION

REPORTER AND USES THEREOF

Methods of Solid-Phase Nucleic Acid Hybridization

MULTIPLEX AMPLIFICATION DETECTION ASSAY