Position-specific modifications

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C12N2310/344

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CCHEMISTRY METALLURGY C12Biochemistry C12NMICRO-ORGANISMS OR ENZYMES COMPOSITIONS THEREOF PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS MUTATION OR GENETIC ENGINEERING CULTURE MEDIA C12N2310/00Structure or type of the nucleic acid

Current Industry

C12N2310/344Position-specific modifications

Industries

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Patents Grantslast 30 patents

Information Patent Grant
Chemically modified single-stranded rna-editing oligonucleotides
- Patent number 12,203,072
- Issue date Jan 21, 2025
- ProQR Therapeutics II B.V.
- Janne Juha Turunen
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
C5a binding nucleic acids
- Patent number 12,188,021
- Issue date Jan 7, 2025
- APTARION biotech AG
- Kai Hohlig
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Fully stabilized asymmetric siRNA
- Patent number 12,173,286
- Issue date Dec 24, 2024
- UNIVERSITY OF MASSACHUSETTS
- Anastasia Khvorova
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Modified guide RNAs
- Patent number 12,173,284
- Issue date Dec 24, 2024
- Intellia Therapeutics, Inc.
- Amy Madison Rhoden Smith
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Modified double-stranded RNA agents
- Patent number 12,168,767
- Issue date Dec 17, 2024
- Alnylam Pharmaceuticals, Inc.
- Martin Maier
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Base editing of ANGPTL3 and methods of using same for treatment of...
- Patent number 12,115,230
- Issue date Oct 15, 2024
- Verve Therapeutics, Inc.
- Alexandra Chadwick
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Nucleic acid, composition and conjugate comprising the same, and pr...
- Patent number 12,084,661
- Issue date Sep 10, 2024
- Suzhou Ribo Life Science Co., Ltd.
- Hongyan Zhang
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Modified oligonucleotides and methods of use
- Patent number 12,077,757
- Issue date Sep 3, 2024
- JANSSEN PHARMACEUTICA NV
- Sergei Gryaznov
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
SERPINA1 iRNA compositions and methods of use thereof
- Patent number 12,071,619
- Issue date Aug 27, 2024
- Alnylam Pharmaceuticals, Inc.
- Alfica Sehgal
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Compositions and methods for ordered and continuous complementary D...
- Patent number 12,054,705
- Issue date Aug 6, 2024
- The Regents of the University of California
- Kathleen Collins
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Nucleic acids for inhibiting expression of LPA in a cell
- Patent number 12,054,717
- Issue date Aug 6, 2024
- Silence Therapeutics GmbH
- Sibylle Dames
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Two-tailed self-delivering siRNA
- Patent number 12,049,627
- Issue date Jul 30, 2024
- University of Massachusetts
- Anastasia Khvorova
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Transthyretin (TTR) iRNA compositions and methods of use thereof fo...
- Patent number 12,049,628
- Issue date Jul 30, 2024
- Alnylam Pharmaceuticals, Inc.
- Tracy Zimmermann
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Targeted compositions
- Patent number 12,043,833
- Issue date Jul 23, 2024
- ARBUTUS BIOPHARMA CORPORATION
- James Heyes
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
4′-phosphate analogs and oligonucleotides comprising the same
- Patent number 12,037,586
- Issue date Jul 16, 2024
- Dicerna Pharmaceuticals, Inc.
- Weimin Wang
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
GNAQ targeted dsRNA compositions and methods for inhibiting expression
- Patent number 12,031,133
- Issue date Jul 9, 2024
- Alnylam Pharmaceuticals, Inc.
- Jared Gollob
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Base editing of PCSK9 and methods of using same for treatment of di...
- Patent number 12,029,795
- Issue date Jul 9, 2024
- Verve Therapeutics, Inc.
- Alexandra Chadwick
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Lipid formulations for delivery of therapeutic agents
- Patent number 12,016,929
- Issue date Jun 25, 2024
- ARBUTUS BIOPHARMA CORPORATION
- Ed Yaworski
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Modification of 3′ terminal ends of nucleic acids by DNA polymerase...
- Patent number 11,993,791
- Issue date May 28, 2024
- Temple University - of the Commonwealth System of Higher Education
- Richard T. Pomerantz
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Products and compositions
- Patent number 11,987,794
- Issue date May 21, 2024
- Silence Therapeutics GmbH
- Judith Hauptmann
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
RNA interference mediated inhibition of gene expression using short...
- Patent number 11,932,854
- Issue date Mar 19, 2024
- SIRNA Therapeutics, Inc.
- Mark Cancilla
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Aptamer therapeutics useful in the treatment of complement-related...
- Patent number 11,913,000
- Issue date Feb 27, 2024
- IVERIC bio, Inc.
- Claude Benedict
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Lipid formulated compositions and methods for inhibiting expression...
- Patent number 11,884,919
- Issue date Jan 30, 2024
- Alnylam Pharmaceuticals, Inc.
- Antonin de Fougerolles
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Allosteric conditional guide RNAs for cell-selective regulation of...
- Patent number 11,873,485
- Issue date Jan 16, 2024
- California Institute of Technology
- Lisa Hochrein
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Nucleic acids for inhibiting expression of a target gene comprising...
- Patent number 11,873,489
- Issue date Jan 16, 2024
- Silence Therapeutics GmbH
- Lucas Bethge
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Chemically modified single-stranded RNA-editing oligonucleotides
- Patent number 11,851,656
- Issue date Dec 26, 2023
- ProQR Therapeutics II B.V.
- Janne Juha Turunen
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Structure-guided chemical modification of guide RNA and its applica...
- Patent number 11,845,933
- Issue date Dec 19, 2023
- Massachusetts Institute of Technology
- Hao Yin
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Compounds and methods for increasing STMN2 expression
- Patent number 11,833,168
- Issue date Dec 5, 2023
- Ionis Pharmaceuticals, Inc.
- Huynh-Hoa Bui
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Lipid formulations for delivery of therapeutic agents
- Patent number 11,786,598
- Issue date Oct 17, 2023
- ARBUTUS BIOPHARMA CORPORATION
- Ed Yaworski
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Micro-RNA and obesity
- Patent number 11,753,639
- Issue date Sep 12, 2023
- Beth Israel Deaconess Medical Center
- Pier Paolo Pandolfi
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...

Patents Applicationslast 30 patents

Information Patent Application
Modified Guide RNAs
- Publication number 20250059532
- Publication date Feb 20, 2025
- INTELLIA THERAPEUTICS, INC.
- Amy Madison Rhoden Smith
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Methods and Compositions for ADAR-Mediated Editing
- Publication number 20250034564
- Publication date Jan 30, 2025
- Korro Bio, Inc.
- Mallikarjuna Reddy Putta
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE ALAS1 GENE
- Publication number 20250034566
- Publication date Jan 30, 2025
- Alnylam Pharmaceuticals, Inc.
- Brian Bettencourt
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
MODIFIED DOUBLE-STRANDED RNA AGENTS
- Publication number 20250034572
- Publication date Jan 30, 2025
- Alnylam Pharmaceuticals, Inc.
- Martin MAIER
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
THERAPEUTIC NUCLEIC ACIDS AND METHODS OF USE THEREOF
- Publication number 20250025487
- Publication date Jan 23, 2025
- Cedars-Sinai Medical Center
- Eduardo Marbán
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
COMPOSITIONS AND METHODS FOR INHIBITING COMPLEMENT COMPONENT 3 EXPR...
- Publication number 20250002908
- Publication date Jan 2, 2025
- AstraZeneca Ireland Limited
- Melissa Lasaro
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
MODIFIED DOUBLE-STRANDED RNA AGENTS
- Publication number 20240409942
- Publication date Dec 12, 2024
- Alnylam Pharmaceuticals, Inc.
- Martin MAIER
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
BASE EDITING OF PCSK9 AND METHODS OF USING SAME FOR TREATMENT OF DI...
- Publication number 20240390523
- Publication date Nov 28, 2024
- Verve Therapeutics, Inc.
- Alexandra Chadwick
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
C5a Binding Nucleic Acids
- Publication number 20240384275
- Publication date Nov 21, 2024
- Aptarion Biotech AG
- Kai Hohlig
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Compositions and methods for ordered and continuous complementary D...
- Publication number 20240344050
- Publication date Oct 17, 2024
- The Regents of the University of California
- Kathleen Collins
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Compositions and methods for ordered and continuous complementary D...
- Publication number 20240344051
- Publication date Oct 17, 2024
- The Regents of the University of California
- Kathleen Collins
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Modification of 3' Terminal Ends of Nucleic Acids by DNA Polymerase...
- Publication number 20240336901
- Publication date Oct 10, 2024
- Richard T. Pomerantz
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
NUCLEIC ACIDS FOR INHIBITING EXPRESSION OF LPA IN A CELL
- Publication number 20240327843
- Publication date Oct 3, 2024
- Silence Therapeutics GMBH
- Sibylle Dames
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
LIPID FORMULATED COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION...
- Publication number 20240327834
- Publication date Oct 3, 2024
- Alnylam Pharmaceuticals, Inc.
- Antonin de Fougerolles
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
NOVEL LIPID FORMULATIONS FOR DELIVERY OF THERAPEUTIC AGENTS
- Publication number 20240316206
- Publication date Sep 26, 2024
- ARBUTUS BIOPHARMA CORPORATION
- Ed Yaworski
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
COMPOUNDS AND METHODS FOR INCREASING STMN2 EXPRESSION
- Publication number 20240316092
- Publication date Sep 26, 2024
- Ionis Pharmaceuticals, Inc.
- Huynh-Hoa Bui
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF TMPRSS6 GENE
- Publication number 20240309386
- Publication date Sep 19, 2024
- Alnylam Pharmaceuticals, Inc.
- David Bumcrot
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
METABOLIC DISORDER-ASSOCIATED TARGET GENE IRNA COMPOSITIONS AND MET...
- Publication number 20240309370
- Publication date Sep 19, 2024
- Alnylam Pharmaceuticals, Inc.
- Aimee M. Deaton
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
OLIGONUCLEOTIDES
- Publication number 20240287510
- Publication date Aug 29, 2024
- Hudson Institute of Medical Research
- Michael GANTIER
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT...
- Publication number 20240287515
- Publication date Aug 29, 2024
- Srina Therapeutics, Inc.
- Mark Cancilla
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
CHEMICALLY MODIFIED SINGLE-STRANDED RNA-EDITING OLIGONUCLEOTIDES
- Publication number 20240271131
- Publication date Aug 15, 2024
- ProQR Therapeutics II B.V.
- Janne Juha Turunen
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE ALAS1 GENE
- Publication number 20240254486
- Publication date Aug 1, 2024
- Alnylam Pharmaceuticals, Inc.
- Brian Bettencourt
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
METHODS FOR TREATING OR PREVENTING CONTACT-ACTIVATION PATHWAY-ASSOC...
- Publication number 20240254482
- Publication date Aug 1, 2024
- Alnylam Pharmaceuticals, Inc.
- James Butler
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
TUNING CRISPR/CAS9 ACTIVITY WITH CHEMICALLY MODIFIED NUCLEOTIDE SUB...
- Publication number 20240229010
- Publication date Jul 11, 2024
- The Royal Institution for the advancement of Learning/McGill University
- Keith Gagnon
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
ANGIOPOIETIN-LIKE 3 (ANGPTL3) IRNA COMPOSITIONS AND METHODS OF USE...
- Publication number 20240200075
- Publication date Jun 20, 2024
- Alnylam Pharmaceuticals, Inc.
- William Querbes
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
NUCLEIC ACIDS FOR INHIBITING EXPRESSION OF A TARGET GENE COMPRISING...
- Publication number 20240200071
- Publication date Jun 20, 2024
- Silence Therapeutics GMBH
- Lucas Bethge
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
CONJUGATES OF SIRNA AND ANTISENSE OLIGONUCLEOTIDES (SIRNASO) AND ME...
- Publication number 20240191230
- Publication date Jun 13, 2024
- University of Massachusetts
- Jonathan Watts
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
RNA SILENCING AGENTS AND METHODS OF USE
- Publication number 20240191229
- Publication date Jun 13, 2024
- ADARx Pharmaceuticals, Inc.
- Zhen Li
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
METHODS AND COMPOSITIONS FOR INHIBITING EXPRESSION OF LDHA
- Publication number 20240182901
- Publication date Jun 6, 2024
- Novo Nordisk Healthcare AG
- Bob D. BROWN
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
NOVEL LIPID FORMULATIONS FOR DELIVERY OF THERAPEUTIC AGENTS
- Publication number 20240148875
- Publication date May 9, 2024
- ARBUTUS BIOPHARMA CORPORATION
- Ed Yaworski
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...

Position-specific modifications

Industry

Parent Industries

Current Industry

Patents Grantslast 30 patents

Chemically modified single-stranded rna-editing oligonucleotides

C5a binding nucleic acids

Fully stabilized asymmetric siRNA

Modified guide RNAs

Modified double-stranded RNA agents

Base editing of ANGPTL3 and methods of using same for treatment of...

Nucleic acid, composition and conjugate comprising the same, and pr...

Modified oligonucleotides and methods of use

SERPINA1 iRNA compositions and methods of use thereof

Compositions and methods for ordered and continuous complementary D...

Nucleic acids for inhibiting expression of LPA in a cell

Two-tailed self-delivering siRNA

Transthyretin (TTR) iRNA compositions and methods of use thereof fo...

Targeted compositions

4′-phosphate analogs and oligonucleotides comprising the same

GNAQ targeted dsRNA compositions and methods for inhibiting expression

Base editing of PCSK9 and methods of using same for treatment of di...

Lipid formulations for delivery of therapeutic agents

Modification of 3′ terminal ends of nucleic acids by DNA polymerase...

Products and compositions

RNA interference mediated inhibition of gene expression using short...

Aptamer therapeutics useful in the treatment of complement-related...

Lipid formulated compositions and methods for inhibiting expression...

Allosteric conditional guide RNAs for cell-selective regulation of...

Nucleic acids for inhibiting expression of a target gene comprising...

Chemically modified single-stranded RNA-editing oligonucleotides

Structure-guided chemical modification of guide RNA and its applica...

Compounds and methods for increasing STMN2 expression

Lipid formulations for delivery of therapeutic agents

Micro-RNA and obesity

Patents Applicationslast 30 patents

Modified Guide RNAs

Methods and Compositions for ADAR-Mediated Editing

COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE ALAS1 GENE

MODIFIED DOUBLE-STRANDED RNA AGENTS

THERAPEUTIC NUCLEIC ACIDS AND METHODS OF USE THEREOF

COMPOSITIONS AND METHODS FOR INHIBITING COMPLEMENT COMPONENT 3 EXPR...

MODIFIED DOUBLE-STRANDED RNA AGENTS

BASE EDITING OF PCSK9 AND METHODS OF USING SAME FOR TREATMENT OF DI...

C5a Binding Nucleic Acids

Compositions and methods for ordered and continuous complementary D...

Compositions and methods for ordered and continuous complementary D...

Modification of 3' Terminal Ends of Nucleic Acids by DNA Polymerase...

NUCLEIC ACIDS FOR INHIBITING EXPRESSION OF LPA IN A CELL

LIPID FORMULATED COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION...

NOVEL LIPID FORMULATIONS FOR DELIVERY OF THERAPEUTIC AGENTS

COMPOUNDS AND METHODS FOR INCREASING STMN2 EXPRESSION

COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF TMPRSS6 GENE

METABOLIC DISORDER-ASSOCIATED TARGET GENE IRNA COMPOSITIONS AND MET...

OLIGONUCLEOTIDES

RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT...

CHEMICALLY MODIFIED SINGLE-STRANDED RNA-EDITING OLIGONUCLEOTIDES

COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE ALAS1 GENE

METHODS FOR TREATING OR PREVENTING CONTACT-ACTIVATION PATHWAY-ASSOC...

TUNING CRISPR/CAS9 ACTIVITY WITH CHEMICALLY MODIFIED NUCLEOTIDE SUB...

ANGIOPOIETIN-LIKE 3 (ANGPTL3) IRNA COMPOSITIONS AND METHODS OF USE...

NUCLEIC ACIDS FOR INHIBITING EXPRESSION OF A TARGET GENE COMPRISING...

CONJUGATES OF SIRNA AND ANTISENSE OLIGONUCLEOTIDES (SIRNASO) AND ME...

RNA SILENCING AGENTS AND METHODS OF USE

METHODS AND COMPOSITIONS FOR INHIBITING EXPRESSION OF LDHA

NOVEL LIPID FORMULATIONS FOR DELIVERY OF THERAPEUTIC AGENTS