reducing unwanted side-effects

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C12N2320/53

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CCHEMISTRY METALLURGY C12Biochemistry C12NMICRO-ORGANISMS OR ENZYMES COMPOSITIONS THEREOF PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS MUTATION OR GENETIC ENGINEERING CULTURE MEDIA C12N2320/00Applications Uses

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C12N2320/53reducing unwanted side-effects

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Patents Grantslast 30 patents

Information Patent Grant
Targeted non-viral DNA insertions
- Patent number 12,234,461
- Issue date Feb 25, 2025
- THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, A CALIFORNIA CORPORATION
- Theodore Lee Roth
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Fully stabilized asymmetric siRNA
- Patent number 12,173,286
- Issue date Dec 24, 2024
- UNIVERSITY OF MASSACHUSETTS
- Anastasia Khvorova
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Organic compositions to treat HSF1-related diseases
- Patent number 12,091,661
- Issue date Sep 17, 2024
- Arrowhead Pharmaceuticals, Inc.
- Gregory Hinkle
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Extended dicer substrate agents and methods for the specific inhibi...
- Patent number 12,077,756
- Issue date Sep 3, 2024
- Dicerna Pharmaceuticals, Inc.
- Bob Dale Brown
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Dosages and methods for delivering lipid formulated nucleic acid mo...
- Patent number 11,827,883
- Issue date Nov 28, 2023
- Alnylam Pharmaceuticals, Inc.
- Pia Kasperkovitz
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Compositions and methods for modulating dysferlin expression
- Patent number 11,827,886
- Issue date Nov 28, 2023
- University of Massachusetts
- Robert H. Brown
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Targeted non-viral DNA insertions
- Patent number 11,814,624
- Issue date Nov 14, 2023
- The Regents of the University of California
- Theodore Lee Roth
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Extended dicer substrate agents and methods for the specific inhibi...
- Patent number 11,634,713
- Issue date Apr 25, 2023
- Dicerna Pharmaceuticals, Inc.
- Bob Dale Brown
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Extended dicer substrate agents and methods for the specific inhibi...
- Patent number 11,597,929
- Issue date Mar 7, 2023
- Dicerna Pharmaceuticals, Inc.
- Bob Dale Brown
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
RNA interference agents for GST-PI gene modulation
- Patent number RE49431
- Issue date Feb 28, 2023
- Nitto Denko Corporation
- Kenjirou Minomi
Information Patent Grant
Therapeutic compositions
- Patent number 11,530,408
- Issue date Dec 20, 2022
- Alnylam Pharmaceuticals, Inc.
- Muthiah Manoharan
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
MicroRNA-based logic gates and uses thereof
- Patent number 11,492,622
- Issue date Nov 8, 2022
- Massachusetts Institute of Technology
- Ron Weiss
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
RNA-modulating agents
- Patent number 11,464,873
- Issue date Oct 11, 2022
- University of Massachusetts
- Phillip D. Zamore
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
CRISPR-based compositions and methods of use
- Patent number 11,459,559
- Issue date Oct 4, 2022
- Integrated DNA Technologies, Inc.
- Michael Allen Collingwood
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Methods of use of CRISPR CPF1 hybrid DNA/RNA polynucleotides
- Patent number 11,459,588
- Issue date Oct 4, 2022
- Caribou Biosciences, Inc.
- Andrew Paul May
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Methods and compositions for treating malignant tumors associated w...
- Patent number RE49229
- Issue date Oct 4, 2022
- Nitto Denko Corporation
- Kenjirou Minomi
Information Patent Grant
Extended dicer substrate agents and methods for the specific inhibi...
- Patent number 11,414,664
- Issue date Aug 16, 2022
- Dicerna Pharmaceuticals, Inc.
- Bob Dale Brown
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Extended dicer substrate agents and methods for the specific inhibi...
- Patent number 11,408,003
- Issue date Aug 9, 2022
- Dicerna Pharmaceuticals, Inc.
- Bob Dale Brown
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Neutral nanotransporters
- Patent number 11,396,654
- Issue date Jul 26, 2022
- Phio Pharmaceuticals Corp.
- Anastasia Khvorova
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Extended dicer substrate agents and methods for the specific inhibi...
- Patent number 11,359,198
- Issue date Jun 14, 2022
- Dicerna Pharmaceuticals, Inc.
- Bob Dale Brown
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Switchable CAS9 nucleases and uses thereof
- Patent number 11,299,755
- Issue date Apr 12, 2022
- President and Fellows of Harvard College
- David R. Liu
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
CRISPR hybrid DNA/RNA polynucleotides and methods of use
- Patent number 11,236,364
- Issue date Feb 1, 2022
- Caribou Biosciences, Inc.
- Andrew Paul May
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
RNA interference compositions and methods for malignant tumors
- Patent number RE48887
- Issue date Jan 11, 2022
- Nitto Denko Corporation
- Yoshiro Niitsu
Information Patent Grant
Mixed tricyclo-DNA, 2′-modified RNA oligonucleotide compositions an...
- Patent number 11,118,179
- Issue date Sep 14, 2021
- SYNTHENA AG
- Wolfgang Andreas Renner
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Modulation of angiopoietin-like 3 expression
- Patent number 11,118,183
- Issue date Sep 14, 2021
- Ionis Pharmaceuticals, Inc.
- Susan M. Freier
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Organic compositions to treat HSF1-related diseases
- Patent number 11,091,761
- Issue date Aug 17, 2021
- Arrowhead Pharmaceuticals, Inc.
- Gregory Hinkle
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Multimeric oligonucleotides having decreased kidney clearance
- Patent number 11,078,484
- Issue date Aug 3, 2021
- MPEG LA, LLC
- Jonathan Miles Brown
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Compositions of asymmetric interfering RNA and uses thereof
- Patent number 11,015,195
- Issue date May 25, 2021
- 1GLOBE HEALTH INSTITUTE LLC
- Chiang Jia Li
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Therapeutic agent for treating cancer comprising anti-miRNA-albumin...
- Patent number 11,015,197
- Issue date May 25, 2021
- Korea Institute of Science and Technology
- Sun Hwa Kim
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Method of target cleaving using CRISPR hybrid DNA/RNA polynucleotides
- Patent number 10,988,781
- Issue date Apr 27, 2021
- Caribou Biosciences, Inc.
- Andrew Paul May
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...

Patents Applicationslast 30 patents

Information Patent Application
GUIDE RNA WITH CHEMICAL MODIFICATIONS
- Publication number 20250092389
- Publication date Mar 20, 2025
- Agilent Technologies, Inc.
- Daniel E. Ryan
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
CRISPR-BASED COMPOSITIONS AND METHODS OF USE
- Publication number 20240318171
- Publication date Sep 26, 2024
- Integrated DNA Technologies, Inc.
- Michael Allen Collingwood
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
NEPHROTOXICITY REDUCING AGENT
- Publication number 20240316093
- Publication date Sep 26, 2024
- Nippon Shinyaku Co., Ltd.
- Takashi HORIUCHI
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
Selective Antisense Compounds and Uses Thereof
- Publication number 20240294923
- Publication date Sep 5, 2024
- Ionis Pharmaceuticals, Inc.
- Michael Oestergaard
- C07 - ORGANIC CHEMISTRY
Information Patent Application
OLIGONUCLEOTIDES
- Publication number 20240287510
- Publication date Aug 29, 2024
- Hudson Institute of Medical Research
- Michael GANTIER
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
Short Duplex DNA as a Novel Gene Silencing Technology and Use Thereof
- Publication number 20240254490
- Publication date Aug 1, 2024
- 1Globe Health Institute LLC
- Chiang J. LI
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
METHOD FOR DESIGNING OLIGONUCLEOTIDE HAVING REDUCED CENTRAL TOXICITY
- Publication number 20240247263
- Publication date Jul 25, 2024
- LUXNA BIOTECH CO., LTD.
- Takaaki KAWANOBE
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
DOSAGES AND METHODS FOR DELIVERING LIPID FORMULATED NUCLEIC ACID MO...
- Publication number 20240175024
- Publication date May 30, 2024
- Alnylam Pharmaceuticals, Inc.
- Pia Kasperkovitz
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
TARGETED NON-VIRAL DNA INSERTIONS
- Publication number 20240117360
- Publication date Apr 11, 2024
- Theodore Lee Roth
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
SYSTEM AND METHOD FOR TISSUE REJUVENATION AND PROTEIN SYNTHESIS BY...
- Publication number 20240093187
- Publication date Mar 21, 2024
- Arthur Mikaelian
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
ANTISENSE COMPOUNDS
- Publication number 20240058370
- Publication date Feb 22, 2024
- Ionis Pharmaceuticals, Inc.
- Eric E. Swayze
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
CHEMICAL MODIFICATIONS FOR INHIBITING EXPRESSION OF ALDH2
- Publication number 20230416752
- Publication date Dec 28, 2023
- Dicerna Pharmaceuticals, Inc.
- Bob Dale BROWN
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
GUIDE RNA WITH CHEMICAL MODIFICATIONS
- Publication number 20230416733
- Publication date Dec 28, 2023
- Agilent Technologies, Inc.
- Daniel E. Ryan
- C07 - ORGANIC CHEMISTRY
Information Patent Application
MODIFIED GAPMER OLIGOMERS AND METHODS OF USE THEREOF
- Publication number 20230383296
- Publication date Nov 30, 2023
- ALIGOS THERAPEUTICS, INC.
- Leonid Beigelman
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
OLIGONUCLEOTIDES
- Publication number 20230348903
- Publication date Nov 2, 2023
- Hudson Institute of Medical Research
- Michael Paul Marie GANTIER
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
TRANSGENE EXPRESSION SYSTEM
- Publication number 20230323391
- Publication date Oct 12, 2023
- THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH
- Stuart Robert COBB
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Guanosine Analogues for Use in Therapeutics Polynucleotides
- Publication number 20230212572
- Publication date Jul 6, 2023
- Roche Innovation Center Copenhagen A/S
- Nanna Albaek
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
CRISPR HYBRID DNA/RNA POLYNUCLEOTIDES AND METHODS OF USE
- Publication number 20230193324
- Publication date Jun 22, 2023
- Caribou Biosciences, Inc.
- Andrew Paul May
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Compositions and Methods for Genome Editing
- Publication number 20230183689
- Publication date Jun 15, 2023
- Shape Therapeutics Inc.
- Debojit BOSE
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
MICRORNA-BASED LOGIC GATES AND USES THEREOF
- Publication number 20230124274
- Publication date Apr 20, 2023
- Massachusetts Institute of Technology
- Ron Weiss
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
SWITCHABLE CAS9 NUCLEASES AND USES THEREOF
- Publication number 20230058176
- Publication date Feb 23, 2023
- President and Fellows of Harvard College
- David R. Liu
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
POLYNUCLEOTIDE EDITORS AND METHODS OF USING THE SAME
- Publication number 20230059368
- Publication date Feb 23, 2023
- PRIME MEDICINE, INC.
- Brian CAFFERTY
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Modulation of Angiopoietin-Like 3 Expression
- Publication number 20220403393
- Publication date Dec 22, 2022
- Ionis Pharmaceuticals, Inc.
- Susan M. FREIER
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
EXTENDED DICER SUBSTRATE AGENTS AND METHODS FOR THE SPECIFIC INHIBI...
- Publication number 20220315925
- Publication date Oct 6, 2022
- Dicerna Pharmaceuticals, Inc.
- Bob Dale Brown
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
RNA COMBINATIONS AND COMPOSITIONS WITH DECREASED IMMUNOSTIMULATORY...
- Publication number 20220296628
- Publication date Sep 22, 2022
- CureVac AG
- Andreas THESS
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
PEPTIDE NUCLEIC ACID COMPOSITIONS WITH MODIFIED HOOGSTEEN BINDING S...
- Publication number 20220243211
- Publication date Aug 4, 2022
- Yale University
- Anisha Gupta
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
EXTENDED DICER SUBSTRATE AGENTS AND METHODS FOR THE SPECIFIC INHIBI...
- Publication number 20220162608
- Publication date May 26, 2022
- Dicerna Pharmaceuticals, Inc.
- Bob Dale Brown
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
OLIGONUCLEOTIDE COMPOSITIONS AND METHODS OF USE THEREOF
- Publication number 20220145300
- Publication date May 12, 2022
- WAVE LIFE SCIENCES LTD.
- Yuanjing Liu
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
RNA INTERFERENCE COMPOSITIONS AND METHODS FOR MALIGNANT TUMORS
- Publication number 20220087531
- Publication date Mar 24, 2022
- Nitto Denko Corporation
- Yoshiro Niitsu
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
TARGETED NON-VIRAL DNA INSERTIONS
- Publication number 20220064653
- Publication date Mar 3, 2022
- The Regents of the University of California
- Theodore Lee Roth
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...

reducing unwanted side-effects

Industry

Parent Industries

Current Industry

Patents Grantslast 30 patents

Targeted non-viral DNA insertions

Fully stabilized asymmetric siRNA

Organic compositions to treat HSF1-related diseases

Extended dicer substrate agents and methods for the specific inhibi...

Dosages and methods for delivering lipid formulated nucleic acid mo...

Compositions and methods for modulating dysferlin expression

Targeted non-viral DNA insertions

Extended dicer substrate agents and methods for the specific inhibi...

Extended dicer substrate agents and methods for the specific inhibi...

RNA interference agents for GST-PI gene modulation

Therapeutic compositions

MicroRNA-based logic gates and uses thereof

RNA-modulating agents

CRISPR-based compositions and methods of use

Methods of use of CRISPR CPF1 hybrid DNA/RNA polynucleotides

Methods and compositions for treating malignant tumors associated w...

Extended dicer substrate agents and methods for the specific inhibi...

Extended dicer substrate agents and methods for the specific inhibi...

Neutral nanotransporters

Extended dicer substrate agents and methods for the specific inhibi...

Switchable CAS9 nucleases and uses thereof

CRISPR hybrid DNA/RNA polynucleotides and methods of use

RNA interference compositions and methods for malignant tumors

Mixed tricyclo-DNA, 2′-modified RNA oligonucleotide compositions an...

Modulation of angiopoietin-like 3 expression

Organic compositions to treat HSF1-related diseases

Multimeric oligonucleotides having decreased kidney clearance

Compositions of asymmetric interfering RNA and uses thereof

Therapeutic agent for treating cancer comprising anti-miRNA-albumin...

Method of target cleaving using CRISPR hybrid DNA/RNA polynucleotides

Patents Applicationslast 30 patents

GUIDE RNA WITH CHEMICAL MODIFICATIONS

CRISPR-BASED COMPOSITIONS AND METHODS OF USE

NEPHROTOXICITY REDUCING AGENT

Selective Antisense Compounds and Uses Thereof

OLIGONUCLEOTIDES

Short Duplex DNA as a Novel Gene Silencing Technology and Use Thereof

METHOD FOR DESIGNING OLIGONUCLEOTIDE HAVING REDUCED CENTRAL TOXICITY

DOSAGES AND METHODS FOR DELIVERING LIPID FORMULATED NUCLEIC ACID MO...

TARGETED NON-VIRAL DNA INSERTIONS

SYSTEM AND METHOD FOR TISSUE REJUVENATION AND PROTEIN SYNTHESIS BY...

ANTISENSE COMPOUNDS

CHEMICAL MODIFICATIONS FOR INHIBITING EXPRESSION OF ALDH2

GUIDE RNA WITH CHEMICAL MODIFICATIONS

MODIFIED GAPMER OLIGOMERS AND METHODS OF USE THEREOF

OLIGONUCLEOTIDES

TRANSGENE EXPRESSION SYSTEM

Guanosine Analogues for Use in Therapeutics Polynucleotides

CRISPR HYBRID DNA/RNA POLYNUCLEOTIDES AND METHODS OF USE

Compositions and Methods for Genome Editing

MICRORNA-BASED LOGIC GATES AND USES THEREOF

SWITCHABLE CAS9 NUCLEASES AND USES THEREOF

POLYNUCLEOTIDE EDITORS AND METHODS OF USING THE SAME

Modulation of Angiopoietin-Like 3 Expression

EXTENDED DICER SUBSTRATE AGENTS AND METHODS FOR THE SPECIFIC INHIBI...

RNA COMBINATIONS AND COMPOSITIONS WITH DECREASED IMMUNOSTIMULATORY...

PEPTIDE NUCLEIC ACID COMPOSITIONS WITH MODIFIED HOOGSTEEN BINDING S...

EXTENDED DICER SUBSTRATE AGENTS AND METHODS FOR THE SPECIFIC INHIBI...

OLIGONUCLEOTIDE COMPOSITIONS AND METHODS OF USE THEREOF

RNA INTERFERENCE COMPOSITIONS AND METHODS FOR MALIGNANT TUMORS

TARGETED NON-VIRAL DNA INSERTIONS