Sedolisin (3.4.21.100)

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CPC
C12Y304/211

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CCHEMISTRY METALLURGY C12Biochemistry C12YENZYMES C12Y304/00Hydrolases acting on peptide bonds

Current Industry

C12Y304/211Sedolisin (3.4.21.100)

Industries

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Patents Grantslast 30 patents

Information Patent Grant
Nucleic acid encoding modified membrane type serine protease 1 (MTS...
- Patent number 12,173,337
- Issue date Dec 24, 2024
- Vertex Pharmaceuticals, Incorporated
- Edwin L. Madison
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Methods for treating conditions associated with MASP-2 dependent co...
- Patent number 11,981,749
- Issue date May 14, 2024
- Omeros Corporation
- Gregory A. Demopulos
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Subtilase variants
- Patent number 11,952,558
- Issue date Apr 9, 2024
- Novozymes A/S
- Miguel Duarte Guilherme Pereira Toscano
- C11 - ANIMAL AND VEGETABLE OILS, FATS, FATTY SUBSTANCES AND WAXES FATTY ACIDS...
Information Patent Grant
Methods for treating and/or preventing graft-versus-host disease an...
- Patent number 11,896,621
- Issue date Feb 13, 2024
- Omeros Corporation
- Gregory A. Demopulos
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Antibodies specifically binding to MASP-3 for the treatment of vari...
- Patent number 11,883,493
- Issue date Jan 30, 2024
- Omeros Corporation
- W. Jason Cummings
- B82 - NANO-TECHNOLOGY
Information Patent Grant
Transmembrane protease, serine 6 (TMPRSS6) iRNA compositions and me...
- Patent number 11,866,710
- Issue date Jan 9, 2024
- Alnylam Pharmaceuticals, Inc.
- Aimee M. Deaton
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
IL-15 prodrugs and methods of use thereof
- Patent number 11,845,801
- Issue date Dec 19, 2023
- AskGene Pharma, Inc.
- Yuefeng Lu
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Modified membrane type serine protease 1 (MTSP-1) polypeptides and...
- Patent number 11,807,882
- Issue date Nov 7, 2023
- Vertex Pharmaceuticals Incorporated
- Edwin L. Madison
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Methods and compositions for diagnosing and treating diseases
- Patent number 11,802,164
- Issue date Oct 31, 2023
- Celera Corporation
- Steve Ruben
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Bakery composition
- Patent number 11,696,585
- Issue date Jul 11, 2023
- Puratos N.V.
- Bram Develter
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Prodruggable antibodies, prodrugs thereof, and methods of use and m...
- Patent number 11,623,965
- Issue date Apr 11, 2023
- Bristol-Myers Squibb Company
- Stanley R. Krystek
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Compositions for inhibiting MASP-2 dependent complement activation
- Patent number 11,613,589
- Issue date Mar 28, 2023
- Omeros Corporation
- Thomas Dudler
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Vertebrate cells and methods for recombinantly expressing a polypep...
- Patent number 11,512,335
- Issue date Nov 29, 2022
- Novartis AG
- Holger Laux
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Modified membrane type serine protease 1 (MTSP-1) polypeptides and...
- Patent number 11,401,513
- Issue date Aug 2, 2022
- Catalyst Biosciences, Inc.
- Edwin L. Madison
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Bakery composition
- Patent number 11,252,969
- Issue date Feb 22, 2022
- Puratos N.V.
- Bram Develter
- A21 - BAKING EDIBLE DOUGHS
Information Patent Grant
Enzyme-inhibitor complexes comprising a thermostable hydrolase and...
- Patent number 11,214,783
- Issue date Jan 4, 2022
- Puratos N.V.
- Geertrui Bosmans
- A21 - BAKING EDIBLE DOUGHS
Information Patent Grant
Antibodies specifically binding to MASP-3 for the treatment of vari...
- Patent number 11,027,015
- Issue date Jun 8, 2021
- Omeros Corporation
- W. Jason Cummings
- B82 - NANO-TECHNOLOGY
Information Patent Grant
Methods for treating and/or preventing graft-versus-host disease an...
- Patent number 11,013,772
- Issue date May 25, 2021
- Omeros Corporation
- Gregory A. Demopulos
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Subtilase variants
- Patent number 10,995,304
- Issue date May 4, 2021
- Novozymes A/S
- Miguel Duarte Guilherme Pereira Toscano
- C11 - ANIMAL AND VEGETABLE OILS, FATS, FATTY SUBSTANCES AND WAXES FATTY ACIDS...
Information Patent Grant
Nucleic acid encoding modified membrane type serine protease 1 (MTS...
- Patent number 10,954,501
- Issue date Mar 23, 2021
- Catalyst Biosciences, Inc.
- Edwin L. Madison
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Modified membrane type serine protease 1 (MTSP-1) polypeptides and...
- Patent number 10,781,435
- Issue date Sep 22, 2020
- Catalyst Biosciences, Inc.
- Edwin L. Madison
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Compositions for inhibiting MASP-2 dependent complement activation
- Patent number 10,683,367
- Issue date Jun 16, 2020
- Omeros Corporation
- Thomas Dudler
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Antibodies specifically binding to MASP-3 for the treatment of vari...
- Patent number 10,639,369
- Issue date May 5, 2020
- Omeros Corporation
- W. Jason Cummings
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Methods for selectively activating a thermostable hydrolase
- Patent number 10,550,380
- Issue date Feb 4, 2020
- Puratos N.V.
- Geertrui Bosmans
- C11 - ANIMAL AND VEGETABLE OILS, FATS, FATTY SUBSTANCES AND WAXES FATTY ACIDS...
Information Patent Grant
Compounds and methods for modulating TMPRSS6 expression
- Patent number 10,415,038
- Issue date Sep 17, 2019
- Ionis Pharmaceuticals, Inc.
- Shuling Guo
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Inhibition of PCSK9 through RNAI
- Patent number 10,167,471
- Issue date Jan 1, 2019
- RXi Pharmaceuticals Corporation
- Joanne Kamens
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Compositions for inhibiting MASP-2 dependent complement activation
- Patent number 10,047,165
- Issue date Aug 14, 2018
- Omeros Corporation
- Thomas Dudler
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Treatment of membrane bound transcription factor peptidase, site 1...
- Patent number 9,879,264
- Issue date Jan 30, 2018
- CuRNA, Inc.
- Joseph Collard
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Modified MT-SP1 proteases that inhibit complement activation
- Patent number 9,795,655
- Issue date Oct 24, 2017
- Catalyst Biosciences, Inc.
- Edwin L. Madison
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Compositions for inhibiting MASP-2 dependent complement activation
- Patent number 9,475,885
- Issue date Oct 25, 2016
- Omeros Corporation
- Thomas Dudler
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE

Patents Applicationslast 30 patents

Information Patent Application
CONJUGATE
- Publication number 20240352463
- Publication date Oct 24, 2024
- Argonaute RNA Limited
- Michael Khan
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Methods for Treating Conditions Associated with MASP-2 Dependent Co...
- Publication number 20240343830
- Publication date Oct 17, 2024
- Omeros Corporation
- Gregory A. Demopulos
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
ANTIBODIES SPECIFICALLY BINDING TO MASP-3 FOR THE TREATMENT OF VARI...
- Publication number 20240342278
- Publication date Oct 17, 2024
- Omeros Corporation
- W. Jason Cummings
- B82 - NANO-TECHNOLOGY
Information Patent Application
TOOL AND METHOD FOR DISAGGREGATION OF POLYQ STRETCH-CONTAINING PROT...
- Publication number 20240327817
- Publication date Oct 3, 2024
- UNIVERSITÄT ZU KOLN
- Ernesto LLAMAS PAMANES
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Methods for Treating and/or Preventing Graft-Versus-Host Disease an...
- Publication number 20240293465
- Publication date Sep 5, 2024
- Omeros Corporation
- Gregory A. Demopulos
- A01 - AGRICULTURE FORESTRY ANIMAL HUSBANDRY HUNTING TRAPPING FISHING
Information Patent Application
TRANSMEMBRANE PROTEASE, SERINE 6 (TMPRSS6) iRNA COMPOSITIONS AND ME...
- Publication number 20240182905
- Publication date Jun 6, 2024
- Alnylam Pharmaceuticals, Inc.
- Aimee M. Deaton
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
SUBTILASE VARIANTS
- Publication number 20240132807
- Publication date Apr 25, 2024
- NOVOZYMES A/S
- Miguel Duarte Guilherme Pereira Toscano
- C11 - ANIMAL AND VEGETABLE OILS, FATS, FATTY SUBSTANCES AND WAXES FATTY ACIDS...
Information Patent Application
COMPOSITIONS FOR INHIBITING MASP-2 DEPENDENT COMPLEMENT ACTIVATION
- Publication number 20240092938
- Publication date Mar 21, 2024
- Omeros Corporation
- Thomas Dudler
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
NOVEL IL-15 PRODRUGS AND METHODS OF USE THEREOF
- Publication number 20240067739
- Publication date Feb 29, 2024
- AskGene Pharma, Inc.
- Yuefeng LU
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
COMPOUNDS AND METHODS FOR MODULATING TMPRSS6 EXPRESSION
- Publication number 20240026364
- Publication date Jan 25, 2024
- Ionis Pharmaceuticals, Inc.
- Shuling Guo
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
NUCLEIC ACID ENCODING MODIFIED MEMBRANE TYPE SERINE PROTEASE 1 (MTS...
- Publication number 20240018502
- Publication date Jan 18, 2024
- VERTEX PHARMACEUTICALS INCORPORATED
- Edwin L. MADISON
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
PURIFICATION PROCESSES FOR POLYSACCHARIDES AND POLYPEPTIDE CONJUGAT...
- Publication number 20240000926
- Publication date Jan 4, 2024
- Vaxcyte, Inc.
- Christopher R. BEHRENS
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
Methods for Treating Conditions Associated with MASP-2 Dependent Co...
- Publication number 20230391889
- Publication date Dec 7, 2023
- University of Leicester
- Hans-Wilhelm Schwaeble
- A01 - AGRICULTURE FORESTRY ANIMAL HUSBANDRY HUNTING TRAPPING FISHING
Information Patent Application
VERTEBRATE CELLS AND METHODS FOR RECOMBINANTLY EXPRESSING A POLYPEP...
- Publication number 20230323419
- Publication date Oct 12, 2023
- Novartis AG
- Holger Laux
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
GROUP A STREP IMMUNOGENIC COMPOSITIONS WITH POLYSACCHARIDE-PROTEIN...
- Publication number 20230293658
- Publication date Sep 21, 2023
- Vaxcyte, Inc.
- Jeffery C. FAIRMAN
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
TRANSMEMBRANE PROTEASE, SERINE 6 (TMPRSS6) iRNA COMPOSITIONS AND ME...
- Publication number 20230220396
- Publication date Jul 13, 2023
- Alnylam Pharmaceuticals, Inc.
- Aimee M. Deaton
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
MANNAN BINDING LECTIN SERINE PEPTIDASE 2 (MASP2) IRNA COMPOSITIONS...
- Publication number 20230125933
- Publication date Apr 27, 2023
- Alnylam Pharmaceuticals, Inc.
- JAMES D. MCININCH
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
COMPOUNDS AND METHODS FOR MODULATING TMPRSS6 EXPRESSION
- Publication number 20220259600
- Publication date Aug 18, 2022
- Ionis Pharmaceuticals, Inc.
- Shuling Guo
- C07 - ORGANIC CHEMISTRY
Information Patent Application
NANOPARTICLE FOR SPECIFICALLY HYDROLYZING TEMPLATE PROTEIN MOLECULE...
- Publication number 20220211867
- Publication date Jul 7, 2022
- Guangzhou University of Chinese Medicine (Guangzhou Institute of Traditional...
- Shixia GUAN
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
APPARATUS FOR THE EXTRACORPOREAL TREATMENT OF BLOOD
- Publication number 20220054731
- Publication date Feb 24, 2022
- University of Limerick
- Jakki Cooney
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
ANTISENSE OLIGONUCLEOTIDES FOR MODULATING HTRA1 EXPRESSION
- Publication number 20220042022
- Publication date Feb 10, 2022
- F. Hoffmann-La Roche AG
- Rubén Alvarez Sánchez
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
AKKERMANSIA MUCINIPHILA STRAIN AND USE THEREOF
- Publication number 20220002665
- Publication date Jan 6, 2022
- KoBioLabs, Inc.
- Gwang Pyo KO
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
MODIFIED MEMBRANE TYPE SERINE PROTEASE 1 (MTSP-1) POLYPEPTIDES AND...
- Publication number 20210355474
- Publication date Nov 18, 2021
- Edwin L. Madison
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
Methods for Treating and/or Preventing Graft-Versus-Host Disease an...
- Publication number 20210290684
- Publication date Sep 23, 2021
- Omeros Corporation
- Gregory A. Demopulos
- C07 - ORGANIC CHEMISTRY
Information Patent Application
ANTIBODIES SPECIFICALLY BINDING TO MASP-3 FOR THE TREATMENT OF VARI...
- Publication number 20210275667
- Publication date Sep 9, 2021
- Omeros Corporation
- W. Jason Cummings
- B82 - NANO-TECHNOLOGY
Information Patent Application
SUBTILASE VARIANTS
- Publication number 20210230516
- Publication date Jul 29, 2021
- NOVOZYMES A/S
- Miguel Duarte Guilherme Pereira Toscano
- C11 - ANIMAL AND VEGETABLE OILS, FATS, FATTY SUBSTANCES AND WAXES FATTY ACIDS...
Information Patent Application
COMPOSITIONS FOR INHIBITING MASP-2 DEPENDENT COMPLEMENT ACTIVATION
- Publication number 20210054099
- Publication date Feb 25, 2021
- Omeros Corporation
- Thomas Dudler
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Methods for Treating Conditions Associated with MASP-2 Dependent Co...
- Publication number 20210047433
- Publication date Feb 18, 2021
- Omeros Corporation
- Gregory A. Demopulos
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
MODIFIED MEMBRANE TYPE SERINE PROTEASE 1 (MTSP-1) POLYPEPTIDES AND...
- Publication number 20210032617
- Publication date Feb 4, 2021
- Catalyst Biosciences, Inc.
- Edwin L. Madison
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
NOVEL IL-15 PRODRUGS AND METHODS OF USE THEREOF
- Publication number 20200392235
- Publication date Dec 17, 2020
- AskGene Pharma, Inc.
- Yuefeng LU
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...

Sedolisin (3.4.21.100)

Industry

Parent Industries

Current Industry

Patents Grantslast 30 patents

Nucleic acid encoding modified membrane type serine protease 1 (MTS...

Methods for treating conditions associated with MASP-2 dependent co...

Subtilase variants

Methods for treating and/or preventing graft-versus-host disease an...

Antibodies specifically binding to MASP-3 for the treatment of vari...

Transmembrane protease, serine 6 (TMPRSS6) iRNA compositions and me...

IL-15 prodrugs and methods of use thereof

Modified membrane type serine protease 1 (MTSP-1) polypeptides and...

Methods and compositions for diagnosing and treating diseases

Bakery composition

Prodruggable antibodies, prodrugs thereof, and methods of use and m...

Compositions for inhibiting MASP-2 dependent complement activation

Vertebrate cells and methods for recombinantly expressing a polypep...

Modified membrane type serine protease 1 (MTSP-1) polypeptides and...

Bakery composition

Enzyme-inhibitor complexes comprising a thermostable hydrolase and...

Antibodies specifically binding to MASP-3 for the treatment of vari...

Methods for treating and/or preventing graft-versus-host disease an...

Subtilase variants

Nucleic acid encoding modified membrane type serine protease 1 (MTS...

Modified membrane type serine protease 1 (MTSP-1) polypeptides and...

Compositions for inhibiting MASP-2 dependent complement activation

Antibodies specifically binding to MASP-3 for the treatment of vari...

Methods for selectively activating a thermostable hydrolase

Compounds and methods for modulating TMPRSS6 expression

Inhibition of PCSK9 through RNAI

Compositions for inhibiting MASP-2 dependent complement activation

Treatment of membrane bound transcription factor peptidase, site 1...

Modified MT-SP1 proteases that inhibit complement activation

Compositions for inhibiting MASP-2 dependent complement activation

Patents Applicationslast 30 patents

CONJUGATE

Methods for Treating Conditions Associated with MASP-2 Dependent Co...

ANTIBODIES SPECIFICALLY BINDING TO MASP-3 FOR THE TREATMENT OF VARI...

TOOL AND METHOD FOR DISAGGREGATION OF POLYQ STRETCH-CONTAINING PROT...

Methods for Treating and/or Preventing Graft-Versus-Host Disease an...

TRANSMEMBRANE PROTEASE, SERINE 6 (TMPRSS6) iRNA COMPOSITIONS AND ME...

SUBTILASE VARIANTS

COMPOSITIONS FOR INHIBITING MASP-2 DEPENDENT COMPLEMENT ACTIVATION

NOVEL IL-15 PRODRUGS AND METHODS OF USE THEREOF

COMPOUNDS AND METHODS FOR MODULATING TMPRSS6 EXPRESSION

NUCLEIC ACID ENCODING MODIFIED MEMBRANE TYPE SERINE PROTEASE 1 (MTS...

PURIFICATION PROCESSES FOR POLYSACCHARIDES AND POLYPEPTIDE CONJUGAT...

Methods for Treating Conditions Associated with MASP-2 Dependent Co...

VERTEBRATE CELLS AND METHODS FOR RECOMBINANTLY EXPRESSING A POLYPEP...

GROUP A STREP IMMUNOGENIC COMPOSITIONS WITH POLYSACCHARIDE-PROTEIN...

TRANSMEMBRANE PROTEASE, SERINE 6 (TMPRSS6) iRNA COMPOSITIONS AND ME...

MANNAN BINDING LECTIN SERINE PEPTIDASE 2 (MASP2) IRNA COMPOSITIONS...

COMPOUNDS AND METHODS FOR MODULATING TMPRSS6 EXPRESSION

NANOPARTICLE FOR SPECIFICALLY HYDROLYZING TEMPLATE PROTEIN MOLECULE...

APPARATUS FOR THE EXTRACORPOREAL TREATMENT OF BLOOD

ANTISENSE OLIGONUCLEOTIDES FOR MODULATING HTRA1 EXPRESSION

AKKERMANSIA MUCINIPHILA STRAIN AND USE THEREOF

MODIFIED MEMBRANE TYPE SERINE PROTEASE 1 (MTSP-1) POLYPEPTIDES AND...

Methods for Treating and/or Preventing Graft-Versus-Host Disease an...

ANTIBODIES SPECIFICALLY BINDING TO MASP-3 FOR THE TREATMENT OF VARI...

SUBTILASE VARIANTS

COMPOSITIONS FOR INHIBITING MASP-2 DEPENDENT COMPLEMENT ACTIVATION

Methods for Treating Conditions Associated with MASP-2 Dependent Co...

MODIFIED MEMBRANE TYPE SERINE PROTEASE 1 (MTSP-1) POLYPEPTIDES AND...

NOVEL IL-15 PRODRUGS AND METHODS OF USE THEREOF