Use of virus as therapeutic agent, other than vaccine

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C12N2710/10332

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CCHEMISTRY METALLURGY C12Biochemistry C12NMICRO-ORGANISMS OR ENZYMES COMPOSITIONS THEREOF PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS MUTATION OR GENETIC ENGINEERING CULTURE MEDIA C12N2710/00dsDNA Viruses

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C12N2710/10332Use of virus as therapeutic agent, other than vaccine

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Patents Grantslast 30 patents

Information Patent Grant
Oncolytic adenovirus with enhanced replication properties comprisin...
- Patent number 12,365,878
- Issue date Jul 22, 2025
- Salk Institute for Biological Studies
- Clodagh O'Shea
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Dosing regime and formulations for type B adenoviruses
- Patent number 12,350,302
- Issue date Jul 8, 2025
- AKAMIS BIO LIMITED
- John Beadle
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
A549 host cells comprising a recombinant oncolytic adenovirus with...
- Patent number 12,291,726
- Issue date May 6, 2025
- EpicentRx, Inc.
- Tony R. Reid
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Adenovirus armed with bispecific T cell engager
- Patent number 12,258,417
- Issue date Mar 25, 2025
- AKAMIS BIO LIMITED
- Brian Robert Champion
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Oncolytic virus or antigen presenting cell mediated cancer therapy...
- Patent number 12,239,666
- Issue date Mar 4, 2025
- H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. INC.
- Amer A. Beg
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Recombinant replication competent viruses comprising a coding regio...
- Patent number 12,233,096
- Issue date Feb 25, 2025
- ORCA Therapeutics B.V.
- Wenliang Dong
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Tumor-selective E1a and E1b mutants
- Patent number 12,195,766
- Issue date Jan 14, 2025
- The Regents of the University of California
- Tony Reid
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Oncolytic adenoviruses for treating cancer
- Patent number 12,129,280
- Issue date Oct 29, 2024
- FUNDACIÓ INSTITUT D'INVESTIGACIÓ BIOMEDICA DE BELLVITGE
- Sònia Guedan Carrió
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Compositions and methods for enhancing production, growth, spread,...
- Patent number 12,076,353
- Issue date Sep 3, 2024
- Ottawa Hospital Research Institute
- Jean-Simon Diallo
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Immunomodulatory fusion proteins
- Patent number 12,054,530
- Issue date Aug 6, 2024
- EpicentRx, Inc.
- Christopher Larson
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Oncolytic group B adenovirus expressing a stroma-targeted bispecifi...
- Patent number 12,049,513
- Issue date Jul 30, 2024
- AKAMIS BIO LIMITED
- Brian Robert Champion
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Cancer therapy
- Patent number 12,031,145
- Issue date Jul 9, 2024
- VALO THERAPEUTICS OY
- Tuuli Ranki
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Therapeutic compositions and methods of use for treating cancer
- Patent number 12,023,362
- Issue date Jul 2, 2024
- AGALIMMUNE LIMITED
- Uri Galili
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Method for producing recombinant oncolytic adenovirus with modified...
- Patent number 11,999,973
- Issue date Jun 4, 2024
- EpicentRx, Inc.
- Tony R. Reid
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Oncolytic adenoviruses armed with heterologous genes
- Patent number 11,938,159
- Issue date Mar 26, 2024
- AKAMIS BIO LIMITED
- Brian Robert Champion
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Rodents having a humanized TMPRSS gene
- Patent number 11,910,787
- Issue date Feb 27, 2024
- REGENERON PHARMACEUTICALS, INC.
- Lisa Purcell
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Recombinant adenoviruses and stem cells comprising same
- Patent number 11,850,215
- Issue date Dec 26, 2023
- GENEMEDICINE CO., LTD.
- Chae Ok Yun
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Adenovirus armed with bispecific T cell activator
- Patent number 11,840,702
- Issue date Dec 12, 2023
- AKAMIS BIO LIMITED
- Brian Champion
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Isolated recombinant oncolytic adenoviruses, pharmaceutical composi...
- Patent number 11,806,374
- Issue date Nov 7, 2023
- HANGZHOU CONVERD CO., LTD.
- Jipo Sheng
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Synthetic adenoviruses with tropism to damaged tissue for use in pr...
- Patent number 11,730,781
- Issue date Aug 22, 2023
- Salk Institute for Biological Studies
- Clodagh O'Shea
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Tumor-selective E1A and E1B mutants
- Patent number 11,618,888
- Issue date Apr 4, 2023
- The Regents of the University of California
- Tony Reid
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Methods of treating bladder cancer
- Patent number 11,596,660
- Issue date Mar 7, 2023
- CG ONCOLOGY, INC.
- Arthur Kuan
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Adenovirus comprising an albumin-binding moiety
- Patent number 11,578,104
- Issue date Feb 14, 2023
- Fundació Institut D'lnvestigació Biomedica De Bellvitge (í DIBELL)
- Ramon Alemany Bonastre
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Oncolytic adenoviruses coding for bi-specific antibodies
- Patent number 11,485,791
- Issue date Nov 1, 2022
- TILT BIOTHERAPEUTICS OY
- Akseli Hemminki
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Membrane lipid coated nanoparticles and method of use
- Patent number 11,471,420
- Issue date Oct 18, 2022
- Coastar Therapeutics Inc.
- Eddie Yocon Chung
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Oncolytic adenoviruses armed with heterologous genes
- Patent number 11,439,678
- Issue date Sep 13, 2022
- Psioxus Therapeutics Limited
- Brian Robert Champion
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Membrane lipid coated viral nanoparticles and method of use
- Patent number 11,413,252
- Issue date Aug 16, 2022
- Coastar Therapeutics Inc.
- Eddie Yocon Chung
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Methods for reversing multiple resistance in animal cells
- Patent number 11,369,650
- Issue date Jun 28, 2022
- Per Sonne Holm
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Detargeted adenovirus variants and related methods
- Patent number 11,364,306
- Issue date Jun 21, 2022
- ADCURE BIOTECHNOLOGIES, LLC.
- Dmitry M. Shayakhmetov
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Methods of treating bladder cancer with an oncolytic virus
- Patent number 11,338,003
- Issue date May 24, 2022
- CG ONCOLOGY, INC.
- Arthur Kuan
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE

Patents Applicationslast 30 patents

Information Patent Application
NASAL ANTI-CANCER THERAPIES
- Publication number 20250152642
- Publication date May 15, 2025
- ORGENESIS INC.
- Oren Moskovich
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
IMMUNOMODULATORY FUSION PROTEINS
- Publication number 20250074967
- Publication date Mar 6, 2025
- EpicentRx, Inc.
- Christopher Larson
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
ADENOVIRUS ARMED WITH BISPECIFIC T CELL ACTIVATOR
- Publication number 20250026851
- Publication date Jan 23, 2025
- AKAMIS BIO LIMITED
- Brian Robert CHAMPION
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
ONCOLYTIC ADENOVIRUSES FOR TREATING CANCER
- Publication number 20250011373
- Publication date Jan 9, 2025
- FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE (IDIBELL)
- Sònia Guedan Carrió
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
ONCOLYTIC ADENOVIRUSES ARMED WITH HETEROLOGOUS GENES
- Publication number 20240325472
- Publication date Oct 3, 2024
- AKAMIS BIO LIMITED
- Brian Robert CHAMPION
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
MEMBRANE LIPID COATED NANOPARTICLES AND METHOD OF USE
- Publication number 20240325314
- Publication date Oct 3, 2024
- Coastar Therapeutics Inc.
- Eddie Yocon Chung
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
COMPOSITIONS AND METHODS FOR ENHANCING PRODUCTION, GROWTH, SPREAD,...
- Publication number 20240307469
- Publication date Sep 19, 2024
- OTTAWA HOSPITAL RESEARCH INSTITUTE
- Jean-Simon Diallo
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
COMPOSITIONS FOR PRODUCING RECOMBINANT VIRUS
- Publication number 20240294883
- Publication date Sep 5, 2024
- EpicentRx, Inc.
- Tony R. Reid
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
ADENOVIRUS FOR ANTI-TUMOUR THERAPY
- Publication number 20240261350
- Publication date Aug 8, 2024
- Medizinische Hochschule Hannover
- Florian Kühnel
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
MODIFIED ADENOVIRUS
- Publication number 20240180982
- Publication date Jun 6, 2024
- University College Cardiff Consultants Limited
- Alan PARKER
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
Adenovirus armed with bispecific T cell activator
- Publication number 20240175052
- Publication date May 30, 2024
- AKAMIS BIO LIMITED
- Brian CHAMPION
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
GENERATION OF DIVERSE VIRAL LIBRARIES
- Publication number 20230265415
- Publication date Aug 24, 2023
- THEOLYTICS LTD.
- Margaret DUFFY
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
ONCOLYTIC ADENOVIRUS WITH REPLICATION SELECTIVITY BASED ON STATUS O...
- Publication number 20230218690
- Publication date Jul 13, 2023
- Salk Institute for Biological Studies
- William Partlo
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
MESENCHYMAL STEM CELLS THAT ENABLE TUMOR TARGETING IMPROVEMENT AND...
- Publication number 20230210927
- Publication date Jul 6, 2023
- Jae Jin SONG
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
DELIVERY OF SIALIDASE TO CANCER CELLS, IMMUNE CELLS AND THE TUMOR M...
- Publication number 20230149487
- Publication date May 18, 2023
- Ansun Biopharma, Inc.
- Nancy CHANG
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
GENE DELIVERY SYSTEM CONTAINING RELAXIN GENE AND PHARMACEUTICAL COM...
- Publication number 20230054820
- Publication date Feb 23, 2023
- Genemedicine Co., Ltd.
- Chae-Ok YUN
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
DETARGETED ADENOVIRUS VARIANTS AND RELATED METHODS
- Publication number 20230001014
- Publication date Jan 5, 2023
- ADCURE BIOTECHNOLOGIES, LLC.
- Dmitry M. Shayakhmetov
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
ADENOVIRUS COMPRISING A MODIFIED ADENOVIRUS HEXON PROTEIN
- Publication number 20220380411
- Publication date Dec 1, 2022
- UNIVERSITAT ULM
- Stefan KOCHANEK
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
VIRUSES WITH MODIFIED CAPSID PROTEINS
- Publication number 20220372514
- Publication date Nov 24, 2022
- SpyBiotech Limited
- Matthew DICKS
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
MEMBRANE LIPID COATED NANOPARTICLES AND METHOD OF USE
- Publication number 20220347110
- Publication date Nov 3, 2022
- Coastar Therapeutics Inc.
- Eddie Yocon Chung
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
METHOD FOR REVERSING MULTIPLE RESISTANCE IN ANIMAL CELLS
- Publication number 20220339219
- Publication date Oct 27, 2022
- Per Sonne Holm
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
METHODS OF TREATING BLADDER CANCER
- Publication number 20220331384
- Publication date Oct 20, 2022
- CG Oncology, Inc.
- Arthur KUAN
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
TREATMENT METHODS USING ADENOVIRUS
- Publication number 20220331383
- Publication date Oct 20, 2022
- Vascular Biogenics Ltd.
- Eyal BREITBART
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
ONCOLYTIC NON-HUMAN ADENOVIRUSES AND USES THEREOF
- Publication number 20220281921
- Publication date Sep 8, 2022
- ACADEMISCH ZIEKENHUIS LEIDEN (H.O.D.N. LUMC)
- Rob Cornelis HOEBEN
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
MEMBRANE LIPID COATED NANOPARTICLES AND METHOD OF USE
- Publication number 20220280438
- Publication date Sep 8, 2022
- Coastar Therapeutics Inc.
- Eddie Yocon Chung
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
Oncolytic adenovirus and checkpoint inhibitor combination therapy
- Publication number 20220251604
- Publication date Aug 11, 2022
- TILT Biotherapeutics Oy
- Akseli Hemminki
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
METHODS AND COMPOSITIONS COMPRISING ENHANCED TARGETED IMMUNE GENE T...
- Publication number 20220226402
- Publication date Jul 21, 2022
- NORTHSHORE UNIVERSITY HEALTH SYSTEM
- Prem SETH
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
PV-DELETED BOVINE ADENOVIRUS
- Publication number 20220154209
- Publication date May 19, 2022
- University of Saskatchewan
- Suresh K. TIKOO
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
ONCOLYTIC ADENOVIRAL VECTOR EXPRESSING PEPTIDYLARGININE DEIMINASE A...
- Publication number 20220154218
- Publication date May 19, 2022
- Targovax ASA
- Lukasz KURYK
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
ONCOLYTIC ADENOVIRAL VECTOR EXPRESSING A MEMBER OF THE B7 FAMILY OF...
- Publication number 20220152134
- Publication date May 19, 2022
- Targovax ASA
- Lukasz KURYK
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE

Use of virus as therapeutic agent, other than vaccine

Industry

Parent Industries

Current Industry

Patents Grantslast 30 patents

Oncolytic adenovirus with enhanced replication properties comprisin...

Dosing regime and formulations for type B adenoviruses

A549 host cells comprising a recombinant oncolytic adenovirus with...

Adenovirus armed with bispecific T cell engager

Oncolytic virus or antigen presenting cell mediated cancer therapy...

Recombinant replication competent viruses comprising a coding regio...

Tumor-selective E1a and E1b mutants

Oncolytic adenoviruses for treating cancer

Compositions and methods for enhancing production, growth, spread,...

Immunomodulatory fusion proteins

Oncolytic group B adenovirus expressing a stroma-targeted bispecifi...

Cancer therapy

Therapeutic compositions and methods of use for treating cancer

Method for producing recombinant oncolytic adenovirus with modified...

Oncolytic adenoviruses armed with heterologous genes

Rodents having a humanized TMPRSS gene

Recombinant adenoviruses and stem cells comprising same

Adenovirus armed with bispecific T cell activator

Isolated recombinant oncolytic adenoviruses, pharmaceutical composi...

Synthetic adenoviruses with tropism to damaged tissue for use in pr...

Tumor-selective E1A and E1B mutants

Methods of treating bladder cancer

Adenovirus comprising an albumin-binding moiety

Oncolytic adenoviruses coding for bi-specific antibodies

Membrane lipid coated nanoparticles and method of use

Oncolytic adenoviruses armed with heterologous genes

Membrane lipid coated viral nanoparticles and method of use

Methods for reversing multiple resistance in animal cells

Detargeted adenovirus variants and related methods

Methods of treating bladder cancer with an oncolytic virus

Patents Applicationslast 30 patents

NASAL ANTI-CANCER THERAPIES

IMMUNOMODULATORY FUSION PROTEINS

ADENOVIRUS ARMED WITH BISPECIFIC T CELL ACTIVATOR

ONCOLYTIC ADENOVIRUSES FOR TREATING CANCER

ONCOLYTIC ADENOVIRUSES ARMED WITH HETEROLOGOUS GENES

MEMBRANE LIPID COATED NANOPARTICLES AND METHOD OF USE

COMPOSITIONS AND METHODS FOR ENHANCING PRODUCTION, GROWTH, SPREAD,...

COMPOSITIONS FOR PRODUCING RECOMBINANT VIRUS

ADENOVIRUS FOR ANTI-TUMOUR THERAPY

MODIFIED ADENOVIRUS

Adenovirus armed with bispecific T cell activator

GENERATION OF DIVERSE VIRAL LIBRARIES

ONCOLYTIC ADENOVIRUS WITH REPLICATION SELECTIVITY BASED ON STATUS O...

MESENCHYMAL STEM CELLS THAT ENABLE TUMOR TARGETING IMPROVEMENT AND...

DELIVERY OF SIALIDASE TO CANCER CELLS, IMMUNE CELLS AND THE TUMOR M...

GENE DELIVERY SYSTEM CONTAINING RELAXIN GENE AND PHARMACEUTICAL COM...

DETARGETED ADENOVIRUS VARIANTS AND RELATED METHODS

ADENOVIRUS COMPRISING A MODIFIED ADENOVIRUS HEXON PROTEIN

VIRUSES WITH MODIFIED CAPSID PROTEINS

MEMBRANE LIPID COATED NANOPARTICLES AND METHOD OF USE

METHOD FOR REVERSING MULTIPLE RESISTANCE IN ANIMAL CELLS

METHODS OF TREATING BLADDER CANCER

TREATMENT METHODS USING ADENOVIRUS

ONCOLYTIC NON-HUMAN ADENOVIRUSES AND USES THEREOF

MEMBRANE LIPID COATED NANOPARTICLES AND METHOD OF USE

Oncolytic adenovirus and checkpoint inhibitor combination therapy

METHODS AND COMPOSITIONS COMPRISING ENHANCED TARGETED IMMUNE GENE T...

PV-DELETED BOVINE ADENOVIRUS

ONCOLYTIC ADENOVIRAL VECTOR EXPRESSING PEPTIDYLARGININE DEIMINASE A...

ONCOLYTIC ADENOVIRAL VECTOR EXPRESSING A MEMBER OF THE B7 FAMILY OF...