viral genome or elements thereof as genetic vector

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C12N2710/24043

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CCHEMISTRY METALLURGY C12Biochemistry C12NMICRO-ORGANISMS OR ENZYMES COMPOSITIONS THEREOF PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS MUTATION OR GENETIC ENGINEERING CULTURE MEDIA C12N2710/00dsDNA Viruses

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C12N2710/24043viral genome or elements thereof as genetic vector

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Patents Grantslast 30 patents

Information Patent Grant
Recombinant viral vector, immune composition containing same, and u...
- Patent number 12,195,517
- Issue date Jan 14, 2025
- Vacdiagn Biotechnology Co., Ltd
- Jianqing Xu
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Viral vectors encoding cancer/testis antigens for use in a method o...
- Patent number 12,180,501
- Issue date Dec 31, 2024
- LUDWIG INSTITUTE FOR CANCER RESEARCH LTD.
- Benoit J. Van Den Eynde
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Non-invasive agent applicator
- Patent number 12,115,333
- Issue date Oct 15, 2024
- MuPharma Pty Ltd
- Harry Unger
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Materials and methods for respiratory disease control in canines
- Patent number 11,865,172
- Issue date Jan 9, 2024
- University of Florida Research Foundation, Inc.
- Patti Cynthia Crawford
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Cassette encoding a FPV/brachyury fusion protein
- Patent number 11,753,652
- Issue date Sep 12, 2023
- Bavarian Nordic A/S
- Zengji Li
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Poxvirus vectors encoding HIV antigens, and methods of use thereof
- Patent number 11,723,970
- Issue date Aug 15, 2023
- Janssen Vaccines & Prevention B.V.
- Frank Wegmann
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Prime/boost immunization regimen against HIV-1 utilizing a multiepi...
- Patent number 11,666,651
- Issue date Jun 6, 2023
- AELIX Therapeutics, S.L.
- Christian Brander
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Apoptotic upregulation by myxoma virus expressing walleye dermal sa...
- Patent number 11,591,616
- Issue date Feb 28, 2023
- Colorado State University Research Foundation
- Amy MacNeill
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Antiviral vaccines with improved cellular immunogenicity
- Patent number 11,331,386
- Issue date May 17, 2022
- Beth Israel Deaconess Medical Center, Inc.
- Dan H. Barouch
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Drug delivery system based on JCV-VLP
- Patent number 11,291,735
- Issue date Apr 5, 2022
- LIFE SCIENCE INKUBATOR BETRIEBS GMBH & CO. KG
- Victoria Demina
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Poxvirus vectors encoding HIV antigens, and methods of use thereof
- Patent number 11,229,693
- Issue date Jan 25, 2022
- Janssen Vaccines & Prevention B.V.
- Frank Wegmann
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Materials and methods for respiratory disease control in canines
- Patent number 11,160,859
- Issue date Nov 2, 2021
- University of Florida Research Foundation, Inc.
- Patti Cynthia Crawford
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Recombinant viral vector systems expressing exogenous feline paramy...
- Patent number 11,033,616
- Issue date Jun 15, 2021
- Hervé Poulet
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Multivalent recombinant SPV
- Patent number 11,020,472
- Issue date Jun 1, 2021
- Ceva Sante Animale
- Takanori Sato
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Methods and compositions for inducing protective immunity against a...
- Patent number 10,925,956
- Issue date Feb 23, 2021
- Janssen Vaccines & Prevention B.V.
- Benoit Christophe Stephan Callendret
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Avian oncolytic virus having modified sequences and uses thereof
- Patent number 10,829,786
- Issue date Nov 10, 2020
- ARV Pharma Inc.
- Robert Kozak
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Antiviral vaccines with improved cellular immunogenicity
- Patent number 10,772,952
- Issue date Sep 15, 2020
- Beth Israel Deaconess Medical Center, Inc.
- Dan H. Barouch
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Poxviral vaccines
- Patent number 10,576,143
- Issue date Mar 3, 2020
- GlaxoSmithKline Biologicals SA
- Stefano Colloca
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Methods and compositions for enhancing immune responses
- Patent number 10,561,722
- Issue date Feb 18, 2020
- Bavarian Nordic A/S
- Ariane Volkmann
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Methods for inducing an immune response against human immunodeficie...
- Patent number 10,525,123
- Issue date Jan 7, 2020
- Janssen Vaccines & Prevention B.V.
- Frank Tomaka
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Antiviral vaccines with improved cellular immunogenicity
- Patent number 10,426,831
- Issue date Oct 1, 2019
- Beth Israel Deaconess Medical Center, Inc.
- Dan H. Barouch
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Hendra virus recombinant compositions and uses thereof
- Patent number 10,350,287
- Issue date Jul 16, 2019
- BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC.
- Jean-Christophe Audonnet
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Methods for inducing an immune response against human immunodeficie...
- Patent number 10,307,477
- Issue date Jun 4, 2019
- Janssen Vaccines & Prevention B.V.
- Frank Tomaka
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Materials and methods for respiratory disease control in canines
- Patent number 10,258,686
- Issue date Apr 16, 2019
- University of Florida Research Foundation, Inc.
- Patti Cynthia Crawford
- G01 - MEASURING TESTING
Information Patent Grant
Method for augmenting vision in persons suffering from photorecepto...
- Patent number 10,259,857
- Issue date Apr 16, 2019
- The General Hospital Corporation
- Richard H. Masland
- A01 - AGRICULTURE FORESTRY ANIMAL HUSBANDRY HUNTING TRAPPING FISHING
Information Patent Grant
Fusion polypeptides and vaccines
- Patent number 10,174,084
- Issue date Jan 8, 2019
- Ceva Sante Animale
- Takanori Sato
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Recombinant swinepox virus and vaccines
- Patent number 10,106,819
- Issue date Oct 23, 2018
- Ceva Sante Animale
- Takanori Sato
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Recombinant CDV compositions and uses thereof
- Patent number 10,076,566
- Issue date Sep 18, 2018
- MERIAL INC.
- Jean-Christophe Audonnet
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Immune regulatory oligonucleotide (IRO) compounds to modulate toll-...
- Patent number 10,066,230
- Issue date Sep 4, 2018
- Idera Pharmaceuticals, Inc.
- Ekambar R. Kandimalla
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Immune regulatory oligonucleotide (IRO) compounds to modulate toll-...
- Patent number 10,041,076
- Issue date Aug 7, 2018
- Idera Pharmaceuticals, Inc.
- Ekambar R. Kandimalla
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE

Patents Applicationslast 30 patents

Information Patent Application
NON-INVASIVE AGENT APPLICATOR
- Publication number 20250032766
- Publication date Jan 30, 2025
- MuPharma Pty Ltd
- Harry Unger
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
COMPOSITION AND METHODS INCLUDING RECOMBINANT VIRUSES MODULATING AR...
- Publication number 20240316130
- Publication date Sep 26, 2024
- UNM Rainforest Innovations
- Eric Bartee
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
AMINO ACIDS, NUCLEOTIDES AND VECTORS EXPRESSING THE SAME AND USES T...
- Publication number 20240261389
- Publication date Aug 8, 2024
- National University of Singapore
- Linfa Wang
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
Use of Ectromelia Virus for Cancer Immunotherapy and Vaccines
- Publication number 20240245765
- Publication date Jul 25, 2024
- Thomas Jefferson University
- Renhuan Xu
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
SARS-COV-2 MULTI-EPITOPE VACCINES
- Publication number 20240238409
- Publication date Jul 18, 2024
- The University of British Columbia
- Wilfred JEFFERIES
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
METHODS OF ENHANCING DIVERSITY OF HLA HAPLOTYPE EXPRESSION IN TUMOR...
- Publication number 20240156869
- Publication date May 16, 2024
- T-Cure Bioscience, Inc.
- Erika VON EUW
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
MULTI-ARMED MYXOMA VIRUS
- Publication number 20240092852
- Publication date Mar 21, 2024
- Oncomyx Therapeutics, Inc.
- Leslie Lynne SHARP
- C07 - ORGANIC CHEMISTRY
Information Patent Application
COVID-19 VACCINE BASED ON THE MYXOMA VIRUS PLATFORM
- Publication number 20230151387
- Publication date May 18, 2023
- Arizona Board of Regents on behalf of Arizona State University
- Grant MCFADDEN
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Prostate Neoantigens And Their Uses
- Publication number 20230029453
- Publication date Feb 2, 2023
- JANSSEN BIOTECH, INC.
- Jason Lee DeHart
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
MATERIALS AND METHODS FOR RESPIRATORY DISEASE CONTROL IN CANINES
- Publication number 20220105171
- Publication date Apr 7, 2022
- University of Florida Research Foundation, Inc.
- PATTI CYNTHIA CRAWFORD
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
ONCOLYTIC MYXOMA VIRUS EXPRESSING FAST P14 TO TREAT HEMATOLOGICAL C...
- Publication number 20220088096
- Publication date Mar 24, 2022
- ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA, ACTING FOR
- Douglas Grant McFADDEN
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Poxvirus Vectors Encoding HIV Antigens, and Methods of Use Thereof
- Publication number 20220088172
- Publication date Mar 24, 2022
- Janssen Vaccines & Prevention B.V.
- Frank WEGMANN
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
RECOMBINANT VIRAL VECTOR, IMMUNE COMPOSITION CONTAINING SAME, AND U...
- Publication number 20220002750
- Publication date Jan 6, 2022
- VACDIAGN BIOTECHNOLOGY CO., LTD
- Jianqing Xu
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Combination Therapy for Treating Cancer with a Poxvirus Expressing...
- Publication number 20210205429
- Publication date Jul 8, 2021
- Bavarian Nordic A/S
- SUSAN FOY
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
VIRAL VECTORS ENCODING CANCER/TESTIS ANTIGENS FOR USE IN A METHOD O...
- Publication number 20210171981
- Publication date Jun 10, 2021
- Benoit J. Van Den Eynde
- C07 - ORGANIC CHEMISTRY
Information Patent Application
ANTIVIRAL VACCINES WITH IMPROVED CELLULAR IMMUNOGENICITY
- Publication number 20200397890
- Publication date Dec 24, 2020
- Beth Israel Deaconess Medical Center, Inc.
- Dan H. BAROUCH
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
RECOMBINANT SWINEPOX VIRUS AND VACCINES
- Publication number 20200390878
- Publication date Dec 17, 2020
- CEVA SANTE ANIMALE
- DOLORES RODRIGUEZ AGUIRRE
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Compositions and Methods for Inducing an Enhanced Immune Response U...
- Publication number 20200325477
- Publication date Oct 15, 2020
- Bavarian Nordic A/S
- Jürgen Hausmann
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
AVIAN ONCOLYTIC VIRUS HAVING MODIFIED SEQUENCES AND USES THEREOF
- Publication number 20200190538
- Publication date Jun 18, 2020
- ARV Pharma Inc.
- Robert KOZAK
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
POXVIRUS VECTORS ENCODING HIV ANTIGENS, AND METHODS OF USE THEREOF
- Publication number 20200138938
- Publication date May 7, 2020
- Janssen Vaccines & Prevention B.V.
- Frank WEGMANN
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
ANTIVIRAL VACCINES WITH IMPROVED CELLULAR IMMUNOGENICITY
- Publication number 20190314492
- Publication date Oct 17, 2019
- Beth Israel Deaconess Medical Center, Inc.
- Dan H. BAROUCH
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
METHOD FOR AUGMENTING VISION IN PERSONS SUFFERING FROM PHOTORECEPTO...
- Publication number 20190263883
- Publication date Aug 29, 2019
- The General Hospital Corporation
- Richard H. MASLAND
- A01 - AGRICULTURE FORESTRY ANIMAL HUSBANDRY HUNTING TRAPPING FISHING
Information Patent Application
NOVEL DRUG DELIVERY SYSTEM BASED ON JCV-VLP
- Publication number 20190201549
- Publication date Jul 4, 2019
- LIFE SCIENCE INKUBATOR BETRIEBS GMBH & CO. KG
- Victoria DEMINA
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
NOVEL DRUG DELIVERY SYSTEM BASED ON JCV-VLP
- Publication number 20180296700
- Publication date Oct 18, 2018
- LIFE SCIENCE INKUBATOR BETRIEBS GMBH & CO. KG
- Victoria Demina
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
PROMOTERS FOR ENHANCING EXPRESSION IN POXVIRUSES
- Publication number 20180216134
- Publication date Aug 2, 2018
- BAVARIAN NORDIC A/S
- Zengji Li
- C07 - ORGANIC CHEMISTRY
Information Patent Application
METHODS AND COMPOSITIONS FOR ENHANCING IMMUNE RESPONSES
- Publication number 20170340721
- Publication date Nov 30, 2017
- BAVARIAN NORDIC A/S
- Ariane VOLKMANN
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
RECOMBINANT SWINEPOX VIRUS AND VACCINES
- Publication number 20170335343
- Publication date Nov 23, 2017
- CEVA SANTE ANIMALE
- TAKANORI SATO
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
POXVIRAL VACCINES
- Publication number 20170333550
- Publication date Nov 23, 2017
- GlaxoSmithKline Biologicals, S.A.
- Stefano COLLOCA
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Non-Invasive Agent Applicator
- Publication number 20170312490
- Publication date Nov 2, 2017
- MuPharma Pty Ltd
- Harry Unger
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
ANTIVIRAL VACCINES WITH IMPROVED CELLULAR IMMUNOGENICITY
- Publication number 20170239344
- Publication date Aug 24, 2017
- Beth Israel Deaconess Medical Center
- Dan H. BAROUCH
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...

viral genome or elements thereof as genetic vector

Industry

Parent Industries

Current Industry

Patents Grantslast 30 patents

Recombinant viral vector, immune composition containing same, and u...

Viral vectors encoding cancer/testis antigens for use in a method o...

Non-invasive agent applicator

Materials and methods for respiratory disease control in canines

Cassette encoding a FPV/brachyury fusion protein

Poxvirus vectors encoding HIV antigens, and methods of use thereof

Prime/boost immunization regimen against HIV-1 utilizing a multiepi...

Apoptotic upregulation by myxoma virus expressing walleye dermal sa...

Antiviral vaccines with improved cellular immunogenicity

Drug delivery system based on JCV-VLP

Poxvirus vectors encoding HIV antigens, and methods of use thereof

Materials and methods for respiratory disease control in canines

Recombinant viral vector systems expressing exogenous feline paramy...

Multivalent recombinant SPV

Methods and compositions for inducing protective immunity against a...

Avian oncolytic virus having modified sequences and uses thereof

Antiviral vaccines with improved cellular immunogenicity

Poxviral vaccines

Methods and compositions for enhancing immune responses

Methods for inducing an immune response against human immunodeficie...

Antiviral vaccines with improved cellular immunogenicity

Hendra virus recombinant compositions and uses thereof

Methods for inducing an immune response against human immunodeficie...

Materials and methods for respiratory disease control in canines

Method for augmenting vision in persons suffering from photorecepto...

Fusion polypeptides and vaccines

Recombinant swinepox virus and vaccines

Recombinant CDV compositions and uses thereof

Immune regulatory oligonucleotide (IRO) compounds to modulate toll-...

Immune regulatory oligonucleotide (IRO) compounds to modulate toll-...

Patents Applicationslast 30 patents

NON-INVASIVE AGENT APPLICATOR

COMPOSITION AND METHODS INCLUDING RECOMBINANT VIRUSES MODULATING AR...

AMINO ACIDS, NUCLEOTIDES AND VECTORS EXPRESSING THE SAME AND USES T...

Use of Ectromelia Virus for Cancer Immunotherapy and Vaccines

SARS-COV-2 MULTI-EPITOPE VACCINES

METHODS OF ENHANCING DIVERSITY OF HLA HAPLOTYPE EXPRESSION IN TUMOR...

MULTI-ARMED MYXOMA VIRUS

COVID-19 VACCINE BASED ON THE MYXOMA VIRUS PLATFORM

Prostate Neoantigens And Their Uses

MATERIALS AND METHODS FOR RESPIRATORY DISEASE CONTROL IN CANINES

ONCOLYTIC MYXOMA VIRUS EXPRESSING FAST P14 TO TREAT HEMATOLOGICAL C...

Poxvirus Vectors Encoding HIV Antigens, and Methods of Use Thereof

RECOMBINANT VIRAL VECTOR, IMMUNE COMPOSITION CONTAINING SAME, AND U...

Combination Therapy for Treating Cancer with a Poxvirus Expressing...

VIRAL VECTORS ENCODING CANCER/TESTIS ANTIGENS FOR USE IN A METHOD O...

ANTIVIRAL VACCINES WITH IMPROVED CELLULAR IMMUNOGENICITY

RECOMBINANT SWINEPOX VIRUS AND VACCINES

Compositions and Methods for Inducing an Enhanced Immune Response U...

AVIAN ONCOLYTIC VIRUS HAVING MODIFIED SEQUENCES AND USES THEREOF

POXVIRUS VECTORS ENCODING HIV ANTIGENS, AND METHODS OF USE THEREOF

ANTIVIRAL VACCINES WITH IMPROVED CELLULAR IMMUNOGENICITY

METHOD FOR AUGMENTING VISION IN PERSONS SUFFERING FROM PHOTORECEPTO...

NOVEL DRUG DELIVERY SYSTEM BASED ON JCV-VLP

NOVEL DRUG DELIVERY SYSTEM BASED ON JCV-VLP

PROMOTERS FOR ENHANCING EXPRESSION IN POXVIRUSES

METHODS AND COMPOSITIONS FOR ENHANCING IMMUNE RESPONSES

RECOMBINANT SWINEPOX VIRUS AND VACCINES

POXVIRAL VACCINES

Non-Invasive Agent Applicator

ANTIVIRAL VACCINES WITH IMPROVED CELLULAR IMMUNOGENICITY