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CCHEMISTRY METALLURGY C12Biochemistry C12NMICRO-ORGANISMS OR ENZYMES COMPOSITIONS THEREOF PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS MUTATION OR GENETIC ENGINEERING CULTURE MEDIA C12N2750/00ssDNA Viruses

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C12N2750/14142virus or viral particle as vehicle

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Patents Grantslast 30 patents

Information Patent Grant
Compositions and methods of treating ocular diseases
- Patent number 12,310,997
- Issue date May 27, 2025
- The Regents of the University of California
- David V. Schaffer
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Methods and compositions for antibody-evading virus vectors
- Patent number 12,281,320
- Issue date Apr 22, 2025
- The University of North Carolina at Chapel Hill
- Aravind Asokan
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Adeno-associated virus factor VIII vectors
- Patent number 12,239,692
- Issue date Mar 4, 2025
- Biomarin Pharmaceutical Inc.
- Peter Cameron Colosi
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
CRISPR/Cas-related methods and compositions for treating Leber's co...
- Patent number 12,234,449
- Issue date Feb 25, 2025
- Editas Medicine, Inc.
- Morgan Lee Maeder
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Compositions and methods to restore paternal UBE3A gene expression...
- Patent number 12,221,609
- Issue date Feb 11, 2025
- University of Connecticut
- Stormy Chamberlain
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Factor IX encoding nucleotides
- Patent number 12,209,262
- Issue date Jan 28, 2025
- UCL BUSINESS LTD
- Amit Nathwani
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Compositions and methods for treatment of dominant retinitis pigmen...
- Patent number 12,203,074
- Issue date Jan 21, 2025
- University of Florida Research Foundation, Incorporated
- Alfred S. Lewin
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Methods of predicting ancestral virus sequences and uses thereof
- Patent number 12,134,786
- Issue date Nov 5, 2024
- Schepens Eye Research Institute, Inc.
- Luk H. Vandenberghe
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
KCNV2 variants and their use
- Patent number 12,116,395
- Issue date Oct 15, 2024
- Artema Therapeutics, Inc.
- Shamil Sultanov
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
High activity regulatory elements
- Patent number 12,104,175
- Issue date Oct 1, 2024
- Encoded Therapeutics, Inc.
- Kartik Ramamoorthi
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Methods for using transcription-dependent directed evolution of AAV...
- Patent number 12,084,654
- Issue date Sep 10, 2024
- Oregon Health & Science University
- Hiroyuki Nakai
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Methods for using transcription-dependent directed evolution of AAV...
- Patent number 12,084,653
- Issue date Sep 10, 2024
- Oregon Health & Science University
- Hiroyuki Nakai
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
AAV vectors targeted to oligodendrocytes
- Patent number 12,076,351
- Issue date Sep 3, 2024
- The University of North Carolina at Chapel Hill
- Thomas McCown
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Methods and compositions for dual glycan binding AAV vectors
- Patent number 12,049,478
- Issue date Jul 30, 2024
- The University of North Carolina at Chapel Hill
- Aravind Asokan
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Use of Mullerian inhibiting substance (MIS) proteins for contracept...
- Patent number 11,998,590
- Issue date Jun 4, 2024
- The General Hospital Corporation
- Patricia K. Donahoe
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Methods for analysis of viral capsid protein composition
- Patent number 11,981,913
- Issue date May 14, 2024
- REGENERON PHARMACEUTICALS, INC.
- Shunhai Wang
- G01 - MEASURING TESTING
Information Patent Grant
Methods of treating rheumatoid arthritis using RNA-guided genome ed...
- Patent number 11,932,867
- Issue date Mar 19, 2024
- National Jewish Health
- Brian Freed
- A01 - AGRICULTURE FORESTRY ANIMAL HUSBANDRY HUNTING TRAPPING FISHING
Information Patent Grant
Compositions and methods for transient delivery of nucleases
- Patent number 11,920,168
- Issue date Mar 5, 2024
- University of Massachusetts
- Guangping Gao
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
RAAV with chemically modified capsid
- Patent number 11,865,185
- Issue date Jan 9, 2024
- Centre National de la Recherche Scientifique (Cnrs)
- Mathieu Mevel
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Vector-mediated immune tolerance in the eye
- Patent number 11,866,480
- Issue date Jan 9, 2024
- The University of North Carolina at Chapel Hill
- Matthew Louis Hirsch
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Adeno-associated variants, formulations and methods for pulmonary d...
- Patent number 11,807,868
- Issue date Nov 7, 2023
- 4D MOLECULAR THERAPEUTICS INC.
- Melissa Kotterman
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Adeno-associated virus vector
- Patent number 11,802,293
- Issue date Oct 31, 2023
- King's College London
- Ralph Michael Linden
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
AAV delivery of shRNA for treatment of pancreatic cancer
- Patent number 11,781,142
- Issue date Oct 10, 2023
- University of Florida Research Foundation, Incorporated
- Maria Zajac-Kaye
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Column-based fully scalable rAAV manufacturing process
- Patent number 11,702,639
- Issue date Jul 18, 2023
- SPARK THERAPEUTICS, INC.
- Guang Qu
- B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
Information Patent Grant
Method of increasing the function of an AAV vector
- Patent number 11,680,274
- Issue date Jun 20, 2023
- The Trustees of the University of Pennsylvania
- Luk Vandenberghe
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
rAAV with chemically modified capsid
- Patent number 11,648,319
- Issue date May 16, 2023
- Centre National de la Recherche Scientifique (Cnrs)
- Mathieu Mevel
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Methods and compositions for dual glycan binding AAV2.5 vector
- Patent number 11,639,509
- Issue date May 2, 2023
- The University of North Carolina at Chapel Hill
- Richard Jude Samulski
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Compositions and methods of treatment
- Patent number 11,634,691
- Issue date Apr 25, 2023
- The Regents of the University of California
- David V. Schaffer
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Methods and compositions for treating hemophilia
- Patent number 11,634,463
- Issue date Apr 25, 2023
- Sangamo Therapeutics, Inc.
- Jeffrey C. Miller
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Targeting peptides for directing adeno-associated viruses (AAVs)
- Patent number 11,499,165
- Issue date Nov 15, 2022
- California Institute of Technology
- Benjamin E. Deverman
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...

Patents Applicationslast 30 patents

Information Patent Application
METHOD OF INCREASING THE FUNCTION OF AN AAV VECTOR
- Publication number 20250179525
- Publication date Jun 5, 2025
- The Trustees of the University of Pennsylvania
- Luk VANDENBERGHE
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
METHOD OF INCREASING THE FUNCTION OF AN AAV VECTOR
- Publication number 20250171801
- Publication date May 29, 2025
- The Trustees of the University of Pennsylvania
- Luk VANDENBERGHE
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
METHODS AND COMPOSITIONS FOR DUAL GLYCAN BINDING AAV VECTORS
- Publication number 20250145670
- Publication date May 8, 2025
- The University of North Carolina at Chapel Hill
- Aravind ASOKAN
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
COMPOSITIONS AND METHODS TO RESTORE PATERNAL UBE3A GENE EXPRESSION...
- Publication number 20250136994
- Publication date May 1, 2025
- University of Connecticut
- Stormy CHAMBERLAIN
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
ENGINEERED MUSCLE TARGETING COMPOSITIONS
- Publication number 20250043309
- Publication date Feb 6, 2025
- THE BROAD INSTITUTE, INC.
- Pardis SABETI
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
COMPOSITIONS AND METHODS FOR THE TREATMENT OF TAU-RELATED DISORDERS
- Publication number 20250034559
- Publication date Jan 30, 2025
- VOYAGER THERAPEUTICS, INC.
- Mathieu Emmanuel NONNENMACHER
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
KCNV2 Variants and Their Use
- Publication number 20250011386
- Publication date Jan 9, 2025
- Artema Therapeutics, Inc.
- Shamil Sultanov
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
NUCLEIC ACID CONSTRUCTS, VIRAL VECTORS AND VIRAL PARTICLES
- Publication number 20240417434
- Publication date Dec 19, 2024
- UCB Biopharma SRL
- Natalia RODRIGUEZ ALVAREZ
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
AAV CAPSID COMPOSITIONS AND METHODS FOR DELIVERY
- Publication number 20240384242
- Publication date Nov 21, 2024
- BioMarin Pharmaceutical Inc.
- Peter COLOSI
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
AAV Vectors Targeted to Oligodendrocytes
- Publication number 20240374662
- Publication date Nov 14, 2024
- The University of North Carolina at Chapel Hill
- Thomas McCown
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
HIGH ACTIVITY REGULATORY ELEMENTS
- Publication number 20240376441
- Publication date Nov 14, 2024
- Encoded Therapeutics, Inc.
- Kartik RAMAMOORTHI
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
METHODS AND COMPOSITIONS FOR DUAL GLYCAN BINDING AAV VECTORS
- Publication number 20240327468
- Publication date Oct 3, 2024
- The University of North Carolina at Chapel Hill
- Aravind ASOKAN
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
Methods of Treating Rheumatoid Arthritis Using RNA-Guided Genome Ed...
- Publication number 20240327862
- Publication date Oct 3, 2024
- The Regents of the University of Colorado, a Body Corporate
- Brian Freed
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
CAPSID VARIANTS AND METHODS OF USING THE SAME
- Publication number 20240294578
- Publication date Sep 5, 2024
- DYNO THERAPEUTICS, INC.
- Sylvain Lapan
- C07 - ORGANIC CHEMISTRY
Information Patent Application
COMPOSITION AND METHOD FOR TREATING HEMOPHILIA B
- Publication number 20240287490
- Publication date Aug 29, 2024
- INSPIRAR LIMITED
- Zhongdong SHI
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
USE OF MULLERIAN INHIBITING SUBSTANCE (MIS) PROTEINS FOR CONTRACEPT...
- Publication number 20240277812
- Publication date Aug 22, 2024
- The General Hospital Corporation
- Patricia K. DONAHOE
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
GENE THERAPY OF HEMOPHILIA A USING VIRAL VECTORS ENCODING RECOMBINA...
- Publication number 20240269241
- Publication date Aug 15, 2024
- Takeda Pharmaceutical Company Limited
- Hanspeter Rottensteiner
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
METHODS OF REDOSING GENE THERAPY VECTORS
- Publication number 20240200096
- Publication date Jun 20, 2024
- BioMarin Pharmaceutical Inc.
- Peter COLOSI
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
VECTOR-MEDIATED IMMUNE TOLERANCE IN THE EYE
- Publication number 20240141015
- Publication date May 2, 2024
- The University of North Carolina at Chapel Hill
- Matthew Louis Hirsch
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
ADENO-ASSOCIATED VIRUS VECTOR
- Publication number 20240124894
- Publication date Apr 18, 2024
- King's College London
- Ralph Michael Linden
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Method of Increasing the Function of an AAV Vector
- Publication number 20240117378
- Publication date Apr 11, 2024
- The Trustees of the University of Pennsylvania
- Luk VANDENBERGHE
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Compositions and Methods of Treating Ocular Diseases
- Publication number 20240091378
- Publication date Mar 21, 2024
- The Regents of the University of California
- David V. Schaffer
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
ADENO-ASSOCIATED VARIANTS, FORMULATIONS AND METHODS FOR PULMONARY D...
- Publication number 20240067987
- Publication date Feb 29, 2024
- 4D MOLECULAR THERAPEUTICS INC.
- Melissa Kotterman
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
METHOD OF INCREASING THE FUNCTION OF AN AAV VECTOR
- Publication number 20230416780
- Publication date Dec 28, 2023
- The Trustees of the University of Pennsylvania
- Luk VANDENBERGHE
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
ADENO-ASSOCIATED VIRUS VECTORS
- Publication number 20230346985
- Publication date Nov 2, 2023
- The Children's Medical Center Corporation
- Zhigang HE
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
METHOD OF INCREASING THE FUNCTION OF AN AAV VECTOR
- Publication number 20230340532
- Publication date Oct 26, 2023
- The Trustees of the University of Pennsylvania
- Luk VANDENBERGHE
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Compositions and Methods of Treatment
- Publication number 20230323311
- Publication date Oct 12, 2023
- The Regents of the University of California
- David V. Schaffer
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
METHOD OF INCREASING THE FUNCTION OF AN AAV VECTOR
- Publication number 20230287452
- Publication date Sep 14, 2023
- The Trustees of the University of Pennsylvania
- Luk VANDENBERGHE
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
METHODS OF PREDICTING ANCESTRAL VIRUS SEQUENCES AND USES THEREOF
- Publication number 20230287359
- Publication date Sep 14, 2023
- Massachusetts Eye and Ear Infirmary
- Luk H. Vandenberghe
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
METHOD OF INCREASING THE FUNCTION OF AN AAV VECTOR
- Publication number 20230272424
- Publication date Aug 31, 2023
- The Trustees of the University of Pennsylvania
- Luk VANDENBERGHE
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE

virus or viral particle as vehicle

Industry

Parent Industries

Current Industry

Patents Grantslast 30 patents

Compositions and methods of treating ocular diseases

Methods and compositions for antibody-evading virus vectors

Adeno-associated virus factor VIII vectors

CRISPR/Cas-related methods and compositions for treating Leber's co...

Compositions and methods to restore paternal UBE3A gene expression...

Factor IX encoding nucleotides

Compositions and methods for treatment of dominant retinitis pigmen...

Methods of predicting ancestral virus sequences and uses thereof

KCNV2 variants and their use

High activity regulatory elements

Methods for using transcription-dependent directed evolution of AAV...

Methods for using transcription-dependent directed evolution of AAV...

AAV vectors targeted to oligodendrocytes

Methods and compositions for dual glycan binding AAV vectors

Use of Mullerian inhibiting substance (MIS) proteins for contracept...

Methods for analysis of viral capsid protein composition

Methods of treating rheumatoid arthritis using RNA-guided genome ed...

Compositions and methods for transient delivery of nucleases

RAAV with chemically modified capsid

Vector-mediated immune tolerance in the eye

Adeno-associated variants, formulations and methods for pulmonary d...

Adeno-associated virus vector

AAV delivery of shRNA for treatment of pancreatic cancer

Column-based fully scalable rAAV manufacturing process

Method of increasing the function of an AAV vector

rAAV with chemically modified capsid

Methods and compositions for dual glycan binding AAV2.5 vector

Compositions and methods of treatment

Methods and compositions for treating hemophilia

Targeting peptides for directing adeno-associated viruses (AAVs)

Patents Applicationslast 30 patents

METHOD OF INCREASING THE FUNCTION OF AN AAV VECTOR

METHOD OF INCREASING THE FUNCTION OF AN AAV VECTOR

METHODS AND COMPOSITIONS FOR DUAL GLYCAN BINDING AAV VECTORS

COMPOSITIONS AND METHODS TO RESTORE PATERNAL UBE3A GENE EXPRESSION...

ENGINEERED MUSCLE TARGETING COMPOSITIONS

COMPOSITIONS AND METHODS FOR THE TREATMENT OF TAU-RELATED DISORDERS

KCNV2 Variants and Their Use

NUCLEIC ACID CONSTRUCTS, VIRAL VECTORS AND VIRAL PARTICLES

AAV CAPSID COMPOSITIONS AND METHODS FOR DELIVERY

AAV Vectors Targeted to Oligodendrocytes

HIGH ACTIVITY REGULATORY ELEMENTS

METHODS AND COMPOSITIONS FOR DUAL GLYCAN BINDING AAV VECTORS

Methods of Treating Rheumatoid Arthritis Using RNA-Guided Genome Ed...

CAPSID VARIANTS AND METHODS OF USING THE SAME

COMPOSITION AND METHOD FOR TREATING HEMOPHILIA B

USE OF MULLERIAN INHIBITING SUBSTANCE (MIS) PROTEINS FOR CONTRACEPT...

GENE THERAPY OF HEMOPHILIA A USING VIRAL VECTORS ENCODING RECOMBINA...

METHODS OF REDOSING GENE THERAPY VECTORS

VECTOR-MEDIATED IMMUNE TOLERANCE IN THE EYE

ADENO-ASSOCIATED VIRUS VECTOR

Method of Increasing the Function of an AAV Vector

Compositions and Methods of Treating Ocular Diseases

ADENO-ASSOCIATED VARIANTS, FORMULATIONS AND METHODS FOR PULMONARY D...

METHOD OF INCREASING THE FUNCTION OF AN AAV VECTOR

ADENO-ASSOCIATED VIRUS VECTORS

METHOD OF INCREASING THE FUNCTION OF AN AAV VECTOR

Compositions and Methods of Treatment

METHOD OF INCREASING THE FUNCTION OF AN AAV VECTOR

METHODS OF PREDICTING ANCESTRAL VIRUS SEQUENCES AND USES THEREOF

METHOD OF INCREASING THE FUNCTION OF AN AAV VECTOR