Claims
- 1. An isolated polypeptide comprising SEQ ID NO: 2.
- 2. An isolated polypeptide according to claim 1, covalently linked at the amino or carboxyl terminus to a moiety selected from the group consisting of affinity tags, toxins, radionucleotides, enzymes and fluorophores.
- 3. A fusion protein comprising a first portion and a second portion joined by a peptide bond, said first portion consisting of a polypeptide selected from the group consisting of:
a) a polypeptide consisting of amino acid residues 23-186 of SEQ ID NO: 2; and b) a polypeptide consisting of amino acid residues 23-319 of SEQ ID NO: 2; and said second portion comprising another polypeptide.
- 4. An isolated polypeptide according to claim 1; in combination with a pharmaceutically acceptable vehicle.
- 5. An antibody or antibody fragment that specifically binds to a polypeptide according to claim 1.
- 6. An antibody according to claim 5, wherein said antibody is selected from the group consisting of:
(a) polyclonal antibody; (b) murine monoclonal antibody; (c) humanized antibody derived from b); (d) an antibody fragment; and (e) human monoclonal antibody.
- 7. An antibody fragment according to claim 5, wherein said antibody fragment is selected from the group consisting of F(ab′), F(ab), Fab′, Fab, Fv, scFv, and minimal recognition unit.
- 8. An anti-idiotype antibody that specifically binds to said antibody of claim 5.
- 10. An isolated nucleic acid molecule encoding a polypeptide of SEQ ID NO: 2.
- 11. An isolated nucleic acid molecule selected from the group consisting of:
a) a nucleic acid molecule of SEQ ID NO: 1; and b) a nucleic acid molecule of SEQ ID NO: 7.
- 12. An isolated polynucleotide encoding a fusion protein comprising a first portion and a second portion joined by a peptide bond, said first portion is selected from the group consisting of:
a) a polypeptide consisting of amino acid residues 23-186 of SEQ ID NO: 2; and b) a polypeptide consisting of amino acid residues 23-319 of SEQ ID NO: 2; and said second portion comprising another polypeptide.
- 13. An expression vector comprising the following operably linked elements:
a transcription promoter; a DNA segment encoding a polypeptide according to claim 1; and a transcription terminator.
- 14. A cultured cell into which has been introduced an expression vector according to claim 13, wherein said cell expresses said polypeptide encoded by said DNA segment.
- 15. A method of producing a polypeptide comprising:
culturing a cell into which has been introduced an expression vector according to claim 13;whereby said cell expresses said polypeptide encoded by said DNA segment; and recovering said expressed polypeptide.
REFERENCE TO RELATED APPLICATION
[0001] This application is related to Provisional Application U.S. 60/254,019, filed on Dec. 7, 2000. Under 35 U.S.C. § 119(e)(1), this application claims benefit of said Provisional Application.
Provisional Applications (1)
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Number |
Date |
Country |
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60254019 |
Dec 2000 |
US |