Claims
- 1. An anti-IL-8 monoclonal antibody, wherein the antibody comprises an antigen binding site comprising the complementarity determining regions of the light chain polypeptide of FIG. 24 (SEQ ID NO:48) and the complementarity determining regions of the heavy chain polypeptide of FIG. 25 (SEQ ID NO:50).
- 2. The antibody of claim 1, wherein the antibody is the monoclonal antibody 6G4.2.5 having ATCC Accession No. HB 11722.
- 3. The antibody of claim 1, wherein the antibody is chimeric.
- 4. The antibody of claim 1, wherein the antibody is humanized.
- 5. The antibody of claim 1, wherein the antibody comprises a first variable region and a second variable region, wherein the first variable region comprises the amino acid sequence of amino acids 1-114 set forth in FIG. 24 (SEQ ID NO:48) and the second variable region comprises the amino acid sequence of amino acids 1-122 set forth in FIG. 25 (SEQ ID NO:50).
- 6. Plasmid pantiIL-8.2 having ATCC Accession No. 97056.
- 7. Plasmid p6G425chim2 having ATCC Accession No. 97055.
- 8. Chimeric fab encoded by p6G425chim2 having ATCC Accession No. 97055.
- 9. An antibody fragment selected from the group consisting of Fab, Fab', Fab'-SH, Fv, and F(ab').sub.2, wherein the antibody fragment comprises the complementarity determining regions of the light chain polypeptide of FIG. 24 (SEQ ID NO:48) and the complementarity determining regions of the heavy chain polypeptide FIG. 25 (SEQ ID NO:50).
- 10. The antibody fragment of claim 9, wherein the antibody fragment is humanized.
- 11. The antibody fragment of claim 9, wherein the antibody fragment is a F(ab').sub.2.
- 12. The antibody fragment of claim 11, wherein the F(ab').sub.2 comprises the variable regions of the light chain polypeptide of FIG. 24 (SEQ ID NO:48) and the heavy chain polypeptide of FIG. 25 (SEQ ID NO:50).
Parent Case Info
This application is a continuation-in-part of U.S. Ser. No. 08/205,864, filed Mar. 3, 1994, now abandoned, which is specifically incorporated by reference herein in its entirety.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
4816567 |
Cabilly et al. |
Mar 1989 |
|
Foreign Referenced Citations (1)
Number |
Date |
Country |
454225 A1 |
Oct 1991 |
EPX |
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
205864 |
Mar 1994 |
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