Fletcher, A., “The Clearance of Heterologous Protein From the Circulation of Normal and Immunized Man1,2”, J Clin Invest 37:1306-1315 (1959). |
Kline, D. et al., “Proactivator Function of Human Plasmin as Shown by Lysine Esterase Assay”, J. Biol. Chem. 236:2807-2812 (1961). |
Wulf et al., “Studies on plasminogen. VIII. Species specificity of streptokinase”, Canadian Journal of Biochemistry, vol. 47, 1969, pp. 927 931. |
McClintock, D. et al., “The Mechanism of Activation of Human Plasminogen by Streptokinase”, Biochem. Biophys. Res.Commun. 43:694-702 (1971). |
Brockway, W. et al., “A Characterization of Native Streptokinase and Altered Streptokinase Isolated from a Juman Plasminogen Activator Complex”, Biochemistry, vol. 13, No. 10, 1974, pp. 2063-2070. |
Markus, G. et al., “Activator Activities of the Transient forms of the Human Plasminogen Streptokinase complex during its Proteolytic Conversion to the Stable Activator Complex”, J Biol Chem 251:6495-6504 (1976). |
Siefring, G. et al., “Interaction of Streptokinase with Plasminogen”, J Biol Chem. 251:3913-20 (1976). |
Wohl, R. et al., “Kinetics of Activation of Human Plasminogen by Different Activator Species at pH 7.4 and 37° C”, J. Biol. Chem. 255:2005-2013 (1980). |
Fears, R. et al., “Kinetic studies on the interaction of streptokinase and other plasminogen activators with plasminogen and fibrin”, Biochem. J. 229:555-558 (1985). |
Malke, H. et al., “Nucleotide sequence of the streptokinase gene from Streptococcus equisimilis H46A”, Gene, 34 (1985). pp. 357-362. |
Jackson et al., “Active Streptokinase from the Cloned Gene in Streptococcus sanguis Is without the Carboxyl-Terminal 32 Residues”, Biochemistry, vol. 25, No. 1, 1986, pp. 108-114. |
Reddy, K., “Streptokinase—biochemistry and Clinical Application”, Enzyme 40:79-89 (1988). |
Huang et al., “Heterogeneity of the Streptokinase Gene in Group A Streptococci”, Infection and Immunity, Feb. 1989, pp. 502-506. |
Huang, T. et al., “The streptokinase gene of group A streptococci: cloning, expression in Escherichia coli, and sequence analysis” Mol. Microbio. 3:197-205 (1989). |
Lee et al., “Site-Specific Alteration of GLY-24 in Streptokinase: Its Effect on Plasminogen Activation”, Biochemical and Biophysical Research Communications, vol. 165, No. 3, 1989, Dec. 29, 1989, pp. 1085-1090. |
Reed et al., “Synergistic fibrinolysis: Combined effects of plasminogen activators and an antibody that inhibits α2-antiplasmin”, Proc. Natl. Acad. Sci. USA, vol. 87, Feb. 1990, pp. 1114-1118. |
Nakashima, A. et al., “Fibrin-dependent activation of plasminogen by a proteolytic digest of streptokinase”, Blood Coagulation and Fibrinolysis, Aug. 1990, pp. 279-284. |
Sherry, S., “Pharmacology of Anistreplase”, Clin Cardiol 13:3-10 (1990). |
Shi et al., “Activation of Human and Bovine Plasminogens by the Microplasmin and Streptokinase Complex”, Thrombosis Research, vol. 58, No. 3, 1990, pp. 317-329. |
McCoy, H. et al., “Streptokinases Produced by Pathogenic Group C Streptococci Demonstrate Species-Specific Plasminogen Activation”, The Journal of Infectious Diseases 1991, pp. 515-521. |
Misselwitz, R. et al., “Limited proteolysis of streptokinase and properties of some fragments”, Int. J. Biol. Macromol., Apr. 1992, vol. 14. |
Johnston, K. et al., “Analysis of the Variable Domain of the Streptokinase Gene from Streptococci Associated with Post-Streptococcal Glomerulonephritis”, New Perspectives on Streptococci and Streptococcal Infections, Supplement 22, 1992, pp. 339-342. |
Reed et al., “A Functional Analysis of the Antigenicity of Streptokinase Using Monoclonal Antibody Mapping and Recombinant Streptokinase Fragments”, The Journal of Immunology, vol. 150, May 15, 1993, pp. 4407-4415. |
Shi et al., “Interaction of Immobilized Human Plasminogen and Plasmin with Streptokinase”, Biochemical and Biophysical Research Communications, vol. 195 No. 1, Aug. 31, 1993, pp. 192-200. |
Ross et al., “The Effects of Tissue Plasminogen Activator, Streptokinase, or Both on Coronary-Artery Patency, Ventriculuar Function, and Survival After Acute Myocardial Infarction”, The New England Journal of Medicine, Nov. 25, 1993, vol. 329, No. 22, pp. 1615-1622. |
Malke, H. et al., “Polymorphism of the Streptokinase Gene: Implications for the Pathogenesis of Post-Streptococcal Glomerulonephritis”, Zbl. Bakt. 278, pp. 246-257 (1993). |
Shi, G. et al., “Function of streptokinase fragments in plasminogen activation”, Biochemical Journal, Nov. 15, 1994, pp. 235-241. |
Nowicki et al., “Characterization of a Novel Streptokinase Produced by Streptococcus equisimilis of Non-Human Origin”, Thrombosis and Hemostasis 72(4), 1994, pp. 595-603. |
Shishido, Y. et al., “Involvement of protease inhibitors in staphylokinase-induced fibrin-specific fibrinolysis”, Biological and Pharmaceutical Bulletin, Dec. 1994. |
Kapur, V. et al., “Molecular population genetic analysis of the streptokinase gene of Streptococcus pyogenes; mosaic alleles generated by recombination”, Molecular Microbiology, 1995, pp. 509-519. |
Parhami-Seren et al., “Mapping the Antigenic Regions of Streptokinase in Humans Before and After Streptokinase Therapy”, Molecular Immunology, vol. 32, No. 10, 1995, pp. 717-724. |
Reed et al., “Identification of a Plasminogen Binding Region in Streptokinase That Is Necessary for the Creation of a Functional Streptokinase—Plasminogen Activator Complex”, Biochemistry, vol. 34, 1995, pp. 10266-10271. |
Young et al., “Interaction of Streptokinase and Plasminogen”, The Journal of Biological Chemistry, vol. 270 No. 49, Dec. 8, 1995, pp. 29601-29606. |
Parrado et al., “The domain organization of streptokinase: Nuclear magnetic resonance, circular dichroism, and functional characterization of proteolytic fragments”, Protein Science (1996), 5:693-704. |
Parhami-Seren et al., “Structural Characterization of Immunodominant Regions of Streptokinase Recognized by Murine Monoclonal Antibodies”, Hybridoma vol. 15, No. 3, 1996, pp. 169-176. |
Lin et al., “Mutation of Lysines in a Plasminogen Binding Region of Streptokinase Identifies Residues Important for Generating a Functional Activator Complex”, Biochemistry 1996, 35, pp. 16879-16885. |
Parhami-Seren et al., “Sequences of Antigenic Epitopes of Streptokinase Identified via Random Peptide Libraries Displayed on Phage”, J. Mol. Biol. (1997) 271, pp. 333-341. |
International Search Report, Apr. 26, 1999. |