Claims
- 1. An isolated nucleic acid sequence comprising a coding region that encodes for a glutamine rich peptide, said peptide consisting of the sequence MET(ALA-GLN)n, -(protease cleavage site)-(ALA-GLN)n wherein n is a number ranging from 1 to 20.
- 2. The nucleic acid sequence of claim 1 further comprising a second sequence operably linked to said coding sequence, said second sequence encoding an intracellular, intercellular or secretory targeting signal.
- 3. The nucleic acid sequence of claim 1 wherein the protease cleavage sites are selected from the group consisting of trypsin, chemotrypsin, Factor Xa and TEV.
- 4. The nucleic acid sequence of claim 1 wherein the coding sequence is operably linked to an inducible or developmentally regulated promoter.
- 5. A transgenic host cell comprising the nucleic acid sequence of claim 1.
- 6. The host cell of claim 5 wherein the nucleic acid sequence further comprises a second sequence operably linked to said coding sequence, said second sequence encoding an intracellular, intercellular or secretory targeting signal.
- 7. The host cell of claim 5 wherein the host cell is a photosynthetic eukaryotic cell.
Parent Case Info
This application claims the benefit of U.S. Provisional Application No. 60/133,014, filed May 7, 1999 herein incorporated by reference in its entirety.
US Referenced Citations (28)
Foreign Referenced Citations (26)
Number |
Date |
Country |
4231675 |
Mar 1994 |
DE |
0082184 |
Jun 1983 |
EP |
87750 |
Sep 1983 |
EP |
0098520 |
Jan 1984 |
EP |
220379 |
May 1987 |
EP |
0250559 |
Jan 1988 |
EP |
0311057 |
Apr 1989 |
EP |
0318446 |
May 1989 |
EP |
0398879 |
Nov 1990 |
EP |
0457314 |
Nov 1991 |
EP |
0571198 |
May 1993 |
EP |
0560989 |
Sep 1993 |
EP |
0634168 |
Jan 1995 |
EP |
0649304 |
Apr 1995 |
EP |
753064 |
Jan 1997 |
EP |
625313 |
Oct 1998 |
EP |
875155 |
Nov 1998 |
EP |
2533827 |
Apr 1984 |
FR |
6234715 |
Aug 1994 |
JP |
8325131 |
Dec 1996 |
JP |
9118010 |
Nov 1991 |
WO |
9209277 |
Jun 1992 |
WO |
9516039 |
Jun 1995 |
WO |
9700081 |
Jan 1997 |
WO |
9705890 |
Feb 1997 |
WO |
9846251 |
Oct 1998 |
WO |
Non-Patent Literature Citations (4)
Entry |
(Rev. Hosp. Clin. Fac. Med. Sao Paulo (2002) 57(4): 187-198).* |
(Curr Opin Clin Nutr Metab Care (1999) 2(4) 323-7).* |
(Clinical Infectious Diseases (2000) 31(1):277).* |
Hadasch et al. (Intervirology (1993) 36: 32-43). |
Provisional Applications (1)
|
Number |
Date |
Country |
|
60/133014 |
May 1999 |
US |