Claims
- 1. A method for identifying a bioactivity or biomolecule of interest, comprising:
(a) introducing a recombinant clone into a capillary tube of a capillary array, wherein each capillary tube of the capillary array comprises at least one wall defining a lumen for retaining the recombinant clone, and wherein the at least one wall is comprised of a material having a low refractive index; (b) exposing the recombinant clone to conditions which induce a detectable signal; and (c) detecting the detectable signal in the capillary tube to identify one or more capillaries containing the detectable signal thereby identifying the bioactivity or biomolecule of interest.
- 2. A method for identifying a bioactivity or biomolecule of interest, comprising:
(a) introducing a recombinant clone into a capillary tube of a capillary array, wherein each capillary tube of the capillary array comprises at least one wall defining a lumen for retaining the recombinant clone, and the at least one wall is comprised of a material having a low refractive index, and wherein the recombinant clone contains a substrate; (b) exposing the recombinant clone to conditions which causes the substrate to produce a detectable signal; and (c) detecting the detectable signal in the capillary tube to identify one or more capillaries containing the detectable signal thereby identifying the bioactivity or biomolecule of interest.
- 3. A method for identifying a bioactivity or biomolecule of interest, comprising:
(a) introducing a recombinant clone into a capillary tube of a capillary array, wherein each capillary tube of the capillary array comprises at least one wall defining a lumen for retaining the recombinant clone, and wherein the recombinant clone contains a substrate; (b) exposing the recombinant clone to conditions which causes the substrate to produce a detectable signal; and (c) detecting the detectable signal in the capillary tube to identify one or more capillaries containing the detectable signal thereby identifying the bioactivity or biomolecule of interest.
- 4. A method for identifying a bioactivity or biomolecule of interest, comprising:
(a) introducing a substrate labeled with a detectable molecule and a recombinant clone into a capillary tube of a capillary array, wherein each capillary tube of the capillary array comprises at least one wall defining a lumen for retaining the substrate and the recombinant clone and wherein each capillary tube in the array is separated from one another by a material with a low refractive index; (b) culturing the capillary tube containing the substrate and the recombinant clone under conditions which allow interaction of the substrate and the recombinant clone to produce a detectable signal; and (c) detecting the detectable signal in the capillary tube to identify one or more capillary tubes containing the detectable signal thereby identifying the bioactivity or biomolecule of interest.
- 5. The method of claim 1, wherein each capillary tube in the array is separated from one another by a material with a low refractive index.
- 6. A method for identifying a bioactivity or biomolecule of interest, comprising:
(a) introducing a recombinant clone containing a substrate into a capillary tube of a capillary array, wherein each capillary tube of the capillary array comprises at least one wall defining a lumen for retaining the recombinant clone and wherein each capillary tube in the array is separated from one another by a material with a low refractive index; (b) exposing the recombinant clone to conditions which causes the substrate to produce a detectable signal; and (c) detecting the detectable signal in the capillary tube to identify one or more capillary tubes containing the detectable signal thereby identifying the bioactivity or biomolecule of interest.
- 7. The method of claim 4, wherein each capillary tube of the capillary array comprises at least a first wall and a second wall wherein the first wall defines a lumen for retaining the substrate and the recombinant clone and is comprised of a material having a high refractive index and the second wall surrounds the first wall and is comprised of a material having a low refractive index, wherein the second wall is in contact with at least one other capillary tube second wall.
- 8. The method of claim 1, wherein each capillary tube of the capillary array comprises at least a first wall and a second wall wherein the first wall defines a lumen for retaining the substrate and the recombinant clone and is comprised of a material having a high refractive index and the second wall surrounds the first wall and is comprised of a material having a low refractive index, wherein the second wall is in contact with at least one other capillary tube second wall.
- 9. The method of claim 2, wherein each capillary tube of the capillary array comprises at least a first wall and a second wall wherein the first wall defines a lumen for retaining the substrate and the recombinant clone and is comprised of a material having a high refractive index and the second wall surrounds the first wall and is comprised of a material having a low refractive index, wherein the second wall is in contact with at least one other capillary tube second wall.
- 10. A method for identifying a compound of interest, comprising:
(a) introducing a sample containing a plurality of compounds into a capillary tube of a capillary array, wherein each capillary tube of the capillary array comprises at least one wall defining a lumen for retaining the sample, and the at least one wall is comprised of a material having a low refractive index, and wherein the recombinant clone contains a substrate; (b) exposing the sample in the capillary tube to conditions which causes the compound of interest to produce a detectable signal; and c) detecting the detectable signal in the capillary tube to identify one or more capillaries containing the detectable signal thereby identifying the compound of interest.
CROSS REFERENCE TO RELATED APPLICATIONS
[0001] This application is a divisional of U.S. application Ser. No. 09/687,219, filed Oct. 12, 2000, which is a continuation-in-part of U.S. patent application Ser. No. 09/444,112, filed Nov. 22, 1999, which is a continuation-in-part of U.S. patent application Ser. No. 08/876,276, filed Jun. 16, 1997, and is a continuation-in-part of U.S. patent application Ser. No. 09/636,778, filed Aug. 11, 2000, which application is a continuation and claims the benefit of priority under 35 U.S.C. § 120 of U.S. patent application Ser. No. 09/098,206, filed Jun. 16, 1998, now U.S. Pat. No. 6,174,673, which is a continuation-in-part of U.S. patent application Ser. No. 08/876,276, filed Jun. 16, 1997, all of the contents of which are incorporated by reference in their entirety herein.
Divisions (1)
|
Number |
Date |
Country |
Parent |
09687219 |
Oct 2000 |
US |
Child |
10156878 |
May 2002 |
US |
Continuations (1)
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Number |
Date |
Country |
Parent |
09098206 |
Jun 1998 |
US |
Child |
09636778 |
Aug 2000 |
US |
Continuation in Parts (4)
|
Number |
Date |
Country |
Parent |
09444112 |
Nov 1999 |
US |
Child |
09687219 |
Oct 2000 |
US |
Parent |
08876276 |
Jun 1997 |
US |
Child |
09444112 |
Nov 1999 |
US |
Parent |
09636778 |
Aug 2000 |
US |
Child |
09444112 |
Nov 1999 |
US |
Parent |
08876276 |
Jun 1997 |
US |
Child |
09098206 |
Jun 1998 |
US |