Claims
- 1. An oligonucleotide having the sequence of SEQ ID NO: 6, wherein at least one adenosine nucleotide is replaced with a thymidine, cytidine or guanosine nucleotide; at least one thymidine nucleotide is replaced with an adenosine, cytidine or guanosine nucleotide; at least one guanosine nucleotide is replaced with an adenosine, thymidine or cytidine nucleotide or at least one cytidine nucleotide is replaced with an adenosine, cytidine or guanosine nucleotide.
- 2. An RNA compound between about 8 and 80 nucleobases in length targeted to HCV genomic or messenger RNA, wherein said compound specifically hybridizes with said HCV genomic or mRNA and inhibits the expression of HCV.
- 3. The compound of claim 2 comprising between about 12 and 50 nucleobases in length.
- 4. The compound of claim 2 comprising between about 15 and 30 nucleobases in length.
- 5. The compound of claim 2, wherein said compound comprises SEQ ID NO: 6.
- 6. The compound of claim 2, wherein said compound is double stranded.
- 7. A double stranded RNA compound having SEQ ID NO: 6.
- 8. The compound of claim 7, wherein at least one adenosine nucleotide is replaced with a thymidine, cytidine or guanosine nucleotide; at least one uridine nucleotide is replaced with an adenosine, cytidine or guanosine nucleotide; at least one guanosine nucleotide is replaced with an adenosine, thymidine or cytidine nucleotide or at least one cytidine nucleotide is replaced with an adenosine, cytidine or guanosine nucleotide
Priority Claims (1)
Number |
Date |
Country |
Kind |
PCT/JP93/01293 |
Sep 1993 |
WO |
|
Parent Case Info
[0001] This application is a continuation-in-part of U.S. Ser. No. ______ (to be determined), filed Jun. 4, 2003, which is a continuation-in-part of U.S. Ser. No. 09/853,409, filed May 11, 2001, which is a continuation-in-part of U.S. Ser. No. 09/690,936 filed Oct. 18, 2000, which is a continuation of U.S. Ser. No. 08/988,321, filed Dec. 10, 1997, now issued as U.S. Pat. No. 6,174,868, which is a continuation-in-part of U.S. Ser. No. 08/650,093, filed May 17, 1996, now issued as U.S. Pat. No. 6,391,542, which is a continuation-in-part of U.S. Ser. No. 08/452,841 filed May 30, 1995, now issued as U.S. Pat. No. 6,423,489, which in turn is a continuation-in-part of U.S. Ser. No. 08/397,220, filed Mar. 9, 1995, now issued as U.S. Pat. No. 6,284,458, which is the U.S. National Phase filing of PCT/JP93/01293 filed Sep. 10, 1993, which is a continuation-in-part of U.S. Ser. No. 07/945,289, filed Sep. 10, 1992, which is now abandoned.