Claims
- 1. A method of stimulating angiogenesis in a mammal, comprising administering to said mammal an effective amount of a polynucleotide encoding CTGF-2, or an active fragment or derivative thereof.
- 2. The method of claim 1, wherein said administered polynucleotide is contained in an adenoviral vector.
- 3. The method of claim 1, wherein the mammal has ischemia.
- 4. The method of claim 1, wherein the mammal has restenosis.
- 5. The method of claim 1, wherein said polynucleotide is delivered to the heart.
- 6. The method of claim 2, wherein the adenoviral vector is pTG14550 deposited with the Pateur Institute as deposit number CNCM I-2695.
- 7. The method of claim 1, wherein the polynucleotide is administered intramuscularly.
- 8. The method of claim 1, wherein the polynucleotide is administered intravenously.
- 9. The method of claim1, wherein the mammal is treated for limb revascularization.
- 10. The method of claim 9, wherein the limb is a leg.
- 11. The method of claim 9, wherein the limb is an arm.
- 12. The method of claim 1, wherein the mammal is human.
- 13. The method of claim 1, wherein the polynucleotide is administered with a pharmaceutically acceptable carrier selected from the group consisting of:
(a) saline, (b) buffered saline, (c) dextrose, (d) water, (e) glycerol, (f) ethanol, and (g) combinations of the above.
- 14. The method of claim 1, wherein the polypeptide or active fragment or derivative thereof is fused to human serum albumin
- 15. A method of stimulating angiogenesis in a mammal, comprising administering to said mammal an effective of a CTGF-2 polypeptide, or an active fragment or derivative thereof.
- 16. The method of claim 15, wherein the mammal has ischemia.
- 17. The method of claim 15, wherein the mammal has restenosis.
- 18. The method of claim 15, wherein the mammal is human
- 19. The method of claim 18, wherein the polypeptide or active fragment or derivative thereof is fused to human serum albumin.
- 20. The method of claim15, wherein the mammal is treated for limb revascularization.
- 21. The method of claim 20, wherein the limb is a leg.
- 22. The method of claim 20, wherein the limb is an arm.
- 23. The method of claim 15, wherein the polynucleotide is administered with a pharmaceutically acceptable carrier selected from the group consisting of:
(a) saline, (b) buffered saline, (c) dextrose, (d) water, (e) glycerol, (f) ethanol, and (g) combinations of the above.
- 24. A method of inhibiting tumor growth by administering an antibody or antibody fragment that specifically binds to CTGF-2.
- 25. An antibody or antibody fragment that specifically binds to a protein whose sequence consists of the protein encoded by the cDNA contained in ATCC Deposit No. 75804.
- 26. An antibody or antibody fragment that specifically binds to a protein whose sequence consists of SEQ ID NO: 2 (as shown in FIGS. 1A-B).
- 27. An antibody or antibody fragment that specifically binds to a protein whose sequence consists of SEQ ID NO: 7 (as shown in FIGS. 1A-C).
Priority Claims (1)
Number |
Date |
Country |
Kind |
PCT/US94/07736 |
Jul 1994 |
WO |
|
Parent Case Info
[0001] This application is a continuation-in-part, and claims benefit under 35 U.S.C. § 120, of copending U.S. patent application Ser. No. 09/348,815, filed Jul. 08, 1999, which is a divisional of U.S. patent application Ser. No. 08/459,101, filed Jun. 02, 1995, which issued as U.S. Pat. No. 5,945,300, which is a continuation-in-part of International Application No. PCT/US94/07736, filed Jul. 12, 1994, which published as International Publication No. WO96/01896 in the English language; and furthermore this application claims benefit under 35 U.S.C. § 119(e) of U.S. Provisional Application Nos. 60/217,402, filed Jul. 11, 2000 and 60/291,642 filed May 18, 2001, each of which provisional, non-provisional, and international applications is hereby incorporated by reference in its entirety.
Provisional Applications (2)
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Number |
Date |
Country |
|
60291642 |
May 2001 |
US |
|
60217402 |
Jul 2000 |
US |
Divisions (1)
|
Number |
Date |
Country |
Parent |
08459101 |
Jun 1995 |
US |
Child |
09901910 |
Jul 2001 |
US |
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
09348815 |
Jul 1999 |
US |
Child |
09901910 |
Jul 2001 |
US |