Patent Grant
10765552
The following commonly assigned U.S. Patent Applications and U.S. Patents are incorporated herein by reference in their entireties:
The present disclosure relates generally to treatment systems and contoured applicators with cooling cups. Several embodiments are directed to cooling cup applicators with contoured heads and/or liner assemblies.
Excess body fat, or adipose tissue, may be present at various locations of a subject's body and may detract from personal appearance. Aesthetic improvement of the human body often involves the selective removal of adipose tissue located at the abdomen, thighs, buttocks, knees, submental region, face and arms, as well as other locations. Invasive procedures (e.g., liposuction), however, tend to be associated with relative high costs, long recovery times, and increased risk of complications. Injection of drugs for reducing adipose tissue can cause significant swelling, bruising, pain, numbness, and/or induration.
Conventional non-invasive treatments for reducing adipose tissue often include regular exercise, application of topical agents, use of weight-loss drugs, dieting, or a combination of these treatments. One drawback of these non-invasive treatments is that they may not be effective or even possible under certain circumstances. For example, when a person is physically injured or ill, regular exercise may not be an option. Topical agents and orally administered weight-loss drugs are not an option if, as another example, they cause an undesirable reaction, such as an allergic or negative reaction. Additionally, non-invasive treatments may be ineffective for selectively reducing specific regions of adiposity, such as localized adipose tissue along the hips, abdomen, thighs, or the like.
Conventional non-invasive vacuum cooling devices suck a fold of skin between two spaced apart cooled plates that are generally parallel to one another. The cooling device can cool and thermally damage targeted tissue. Unfortunately, only opposites sides of the skin fold contact the cooled plates, which limits the cooling capabilities of the cooling devices. Additionally, the end of the tissue fold located in a gap between the plates may experience pooling of blood. A vacuum may cause rupturing of blood vessels and lead to bruising of the skin located in the gap. Accordingly, conventional invasive and non-invasive treatments are not suitable for many subjects and cannot effectively target certain regions of tissue.
In the drawings, identical reference numbers identify similar elements or acts.
The present disclosure describes treatment systems, applicators, and methods for affecting targeted sites. Several embodiments are directed to non-invasive systems that cool/heat specific regions or volumes of tissue. The non-invasive systems can include applicators with thermally-conductive cooling cups for cooling the skin surface of a retained volume of tissue. The applicators can be reconfigurable to enable treatment at various sites. Several of the details set forth below are provided to describe the following examples and methods in a manner sufficient to enable a person skilled in the relevant art to practice, make, and use them. Several of the details and advantages described below, however, may not be necessary to practice certain examples and methods of the technology. Additionally, the technology may include other examples and methods that are within the scope of the technology but are not described in detail.
Systems for treating a subject's tissue can include a cooling cup applicator with a base unit having a tissue-receiving cavity. A contoured head can be coupled to the base unit to provide a suitable interface for sealing with the subject's skin. A sealing member can be disposed between the base unit and the contoured head to create and maintain a vacuum seal therebetween. Once the contoured head is pressed against the subject's skin, a vacuum can be drawn to pull tissue through the head into the tissue-receiving cavity. A temperature-controlled surface of the cooling cup can then conductively cool/heat the skin. Different contoured heads can be alternatively attached to the base unit and sealing member to create various sizes of applicators to be able to treat various treatment sites, specific volumes of tissue, or the like. Sealing members can be located at various locations to provide sealing (e.g., liquid-tight sealing, air-tight sealing, etc.) between components of the applicators. The seals can be maintained throughout treatment.
A disposable liner assembly can optionally be coupled to or integrated with the applicator to provide a sanitary patient-contact surface. The applicator can securely hold the liner assembly to allow repositioning of the applicator along the patient. The liner assembly can be replaced with another linear assembly to perform procedures on another patient to, for example, prevent cross-contamination between patients. The liner assembly can include a liner which is attached to the sealing member, with the liner extending across the tissue receiving cavity of the base unit. In some treatments, contoured heads, liner assemblies, and/or patient contact elements can be replaced to avoid cross-contamination between patients. Accordingly, most or all of the surfaces of the applicator that contact the patient can be replaced at any time.
The applicator can have one or more vacuum ports used to draw the liner assembly and/or tissue into the tissue-receiving cavity. In some embodiments, the liner assembly has an adhesive surface for adhering to the cooling cup and can be perforated to allow air flow therethrough. The liner assembly can be made, in whole or in part, of plastic, rubber, or other suitable material and can include, without limitation, one or more sealing members, sensors, release liners, carriers, alignment features, or the like.
Tissue can be pulled into the applicator such that the tissue fills most or substantially all of the tissue-receiving cavity. In some embodiments, a vacuum can be drawn to pull the skin against a relatively large area of the cup, thereby providing a relatively large skin-cup interface for heat transfer. A temperature-controlled conductive surface of the cooling cup can extend continuously along spaced apart sidewalls and bottom of the cooling cup and can thermally contact an area of the subject's skin that is equal to or less than about 20 cm2, 40 cm2, 80 cm2, 100 cm2, 140 cm2, 160 cm2, 180 cm2, 200 cm2, 300 cm2, or other suitable area. In some embodiments, the temperature-controlled conductive surface can be cooled to a temperature equal to or less than a selected temperature (e.g., 5° C., 0° C., −2° C., −5° C., −7° C., −10° C., −15° C., −20° C., −25° C., etc.) to cool most of the skin surface of the retained tissue. In some embodiments, most of a heat-exchanging surface of the cup can be cooled to a temperature equal to or less than about 0° C., −2° C., −5° C., −10° C., or −15° C. The temperature-controlled surface area of the cooling cup can be, for example, equal to or less than 20 cm2, 40 cm2, 80 cm2, 100 cm2, 140 cm2, 160 cm2, 180 cm2, 200 cm2, 300 cm2, or another suitable area.
In some embodiments, an apparatus for treating a subject's tissue includes an applicator configured to cool targeted tissue and a controller. The applicator includes a base unit, a head, a sealing member, and optionally a liner. The base unit has a temperature-controlled cup with a conductive heat-exchanging surface defining a tissue-receiving cavity. The head is removably coupleable to the base unit and includes a mounting body and a contoured mouth. The mounting body is configured to be coupled to the base unit to position an opening defined by the contoured mouth with respect to an entrance of the tissue-receiving cavity. The sealing member is disposed between the base unit and the head to create a vacuum seal therebetween. When the liner is used, a liner assembly can include the sealing member and the liner. The sealing member is positionable between the mounting body of the head and the base unit such that the liner extends across the entrance of the tissue-receiving cavity. The liner can be drawn into the tissue-receiving cavity until the liner lines the conductive surface. A majority or the entire liner can be located within the apparatus when the liner lines the conductive surface. The controller can be programmed to command the applicator to draw a vacuum in the tissue-receiving cavity to pull the liner against the conductive heat-exchanging surface.
In another embodiment, an apparatus for treating a subject's tissue comprises a base unit, a head, and a sealing member. The base unit includes a temperature-controlled cup having a conductive surface defining a tissue-receiving cavity. The head includes a mounting body and a contoured mouth. The mounting body is configured to be coupled to the base unit to position an opening defined by the contoured mouth with respect to an entrance of the tissue-receiving cavity. The sealing member is between the base unit and the head to create a seal (e.g., a vacuum seal or other desired seal) therebetween. A liner assembly can include the sealing member and a liner. The sealing member is positionable between the mounting body of the head and the base unit such that the liner extends across the entrance of the tissue-receiving cavity. The liner assembly can be drawn through the tissue-receiving cavity and against at least a portion of the conductive surface of the cup. Sealing members can be installed at other locations to inhibit or prevent leakage (e.g., air leakage into or out of the applicator).
In some embodiments, a contoured head can be configured to clamp onto a base unit via the sealing member to form an applicator. The applicator can be applied to treatment sites while the sealing member remains secured to the applicator, and one can release the sealing member and separate the contoured head from the base unit so as to install another contoured head and sealing member to the base unit. In some embodiments, a liner assembly can be sandwiched between the base unit and contoured head of the applicator. The liner assemblies can be located at suitable joints to limit or reduce deformation, movement, etc. of the liner assembly.
In some procedures, a contoured head is positioned over a liner assembly, which is positioned on a base unit, to clamp together components of the applicator. The liner assembly can be sucked against the entire cup surface for heating/cooling tissue such that the liner adheres to the cup. For example, the liner assembly can be adhered to sidewalls, bottom, or another portion of the cup. One or more holes can be formed (e.g., punched) along the liner assembly to establish vacuum pathways through the liner assembly. Filters, gel traps, and/or other features can be inserted into the holes to inhibit or prevent substances (e.g., cryoprotectants) from being sucked into components of the base unit. The vacuum can be reduced or stopped to place to place the applicator on a subject and then tissue can be suck into the applicator. Temperature sensors, contact sensors, and/or other sensors can be used to monitor, for example, temperatures (e.g., tissue temperatures, cup temperatures, etc.), the presence of tissue, tissue draw (e.g., movement of tissue, amount of tissue in the applicator, etc.), tissue retention, applicator operation, and so forth.
At least some methods for treating a subject's tissue include positioning one or more sealing members between a head and a base unit of an applicator. Optionally a liner assembly can be used that includes a liner that extends across an entrance of a tissue-receiving cavity of the applicator. A vacuum can be drawn in the tissue-receiving cavity to move an adhesive surface of the liner into physical contact with a conductive surface of the temperature-controlled cup. After adhering the liner to the conductive surface, the liner assembly can be perforated to establish fluid communication between at least one vacuum port of the applicator and the tissue-receiving cavity. This allows tissue to be pulled into the applicator via a vacuum.
Some of the embodiments disclosed herein can be for cosmetically beneficial alterations of target regions. Some cosmetic procedures may be for the sole purpose of altering a target region to conform to a cosmetically desirable look, feel, size, shape and/or other desirable cosmetic characteristic or feature. Accordingly, at least some embodiments of the cosmetic procedures can be performed without providing an appreciable therapeutic effect (e.g., no therapeutic effect). For example, some cosmetic procedures may not include restoration of health, physical integrity, or the physical well-being of a subject. The cosmetic methods can target subcutaneous regions to change a subject's appearance and can include, for example, procedures performed on subject's submental region, abdomen, hips, legs, face, neck, ankle region, or the like. In other embodiments, however, cosmetically desirable treatments may have therapeutic outcomes (whether intended or not), such as psychological benefits, alteration of body hormones levels (by the reduction of adipose tissue), etc.
Reference throughout this specification to “one example,” “an example,” “one embodiment,” or “an embodiment” means that a particular feature, structure, or characteristic described in connection with the example is included in at least one example of the present technology. Thus, the occurrences of the phrases “in one example,” “in an example,” “one embodiment,” or “an embodiment” in various places throughout this specification are not necessarily all referring to the same example. Furthermore, the particular features, structures, routines, stages, or characteristics may be combined in any suitable manner in one or more examples of the technology. The headings provided herein are for convenience only and are not intended to limit or interpret the scope or meaning of the technology.
The treatment system 100 can perform medical treatments to provide therapeutic effects and/or cosmetic procedures for cosmetically beneficial effects. Without being bound by theory, selective effects of cooling are believed to result in, for example, membrane disruption, cell shrinkage, disabling, disrupting, damaging, destroying, removing, killing and/or other methods of lipid-rich cell alteration. Such alteration is believed to stem from one or more mechanisms acting alone or in combination. It is thought that such mechanism(s) trigger an apoptotic cascade, which is believed to be the dominant form of lipid-rich cell death by non-invasive cooling. In any of these embodiments, the effect of tissue cooling can be the selectively reduction of lipid-rich cells by a desired mechanism of action, such as apoptosis, lipolysis, or the like. In some procedures, the applicator 102 can cool the skin surface and/or targeted tissue to cooling temperature in a range of from about −25° C. to about 20° C. In other embodiments, the cooling temperatures can be from about −20° C. to about 10° C., from about −18° C. to about 5° C., from about −15° C. to about 5° C., or from about −15° C. to about 0° C. In further embodiments, the cooling temperatures can be equal to or less than −5° C., −10° C., −15° C., or in yet another embodiment, from about −15° C. to about −25° C. Other cooling temperatures and temperature ranges can be used.
Apoptosis, also referred to as “programmed cell death”, is a genetically-induced death mechanism by which cells self-destruct without incurring damage to surrounding tissues. An ordered series of biochemical events induce cells to morphologically change. These changes include cellular blebbing, loss of cell membrane asymmetry and attachment, cell shrinkage, chromatin condensation and chromosomal DNA fragmentation. Injury via an external stimulus, such as cold exposure, is one mechanism that can induce cellular apoptosis in cells. Nagle, W. A., Soloff, B. L., Moss, A. J. Jr., Henle, K. J. “Cultured Chinese Hamster Cells Undergo Apoptosis After Exposure to Cold but Nonfreezing Temperatures” Cryobiology 27, 439-451 (1990).
One aspect of apoptosis, in contrast to cellular necrosis (a traumatic form of cell death causing local inflammation), is that apoptotic cells express and display phagocytic markers on the surface of the cell membrane, thus marking the cells for phagocytosis by macrophages. As a result, phagocytes can engulf and remove the dying cells (e.g., the lipid-rich cells) without eliciting an immune response. Temperatures that elicit these apoptotic events in lipid-rich cells may contribute to long-lasting and/or permanent reduction and reshaping of subcutaneous adipose tissue.
One mechanism of apoptotic lipid-rich cell death by cooling is believed to involve localized crystallization of lipids within the adipocytes at temperatures that do not induce crystallization in non-lipid-rich cells. The crystallized lipids selectively may injure these cells, inducing apoptosis (and may also induce necrotic death if the crystallized lipids damage or rupture the bi-lipid membrane of the adipocyte). Another mechanism of injury involves the lipid phase transition of those lipids within the cell's bi-lipid membrane, which results in membrane disruption or dysfunction, thereby inducing apoptosis. This mechanism is well-documented for many cell types and may be active when adipocytes, or lipid-rich cells, are cooled. Mazur, P., “Cryobiology: the Freezing of Biological Systems” Science, 68: 939-949 (1970); Quinn, P. J., “A Lipid Phase Separation Model of Low Temperature Damage to Biological Membranes” Cryobiology, 22: 128-147 (1985); Rubinsky, B., “Principles of Low Temperature Preservation” Heart Failure Reviews, 8, 277-284 (2003). Other possible mechanisms of adipocyte damage, described in U.S. Pat. No. 8,192,474, relate to ischemia/reperfusion injury that may occur under certain conditions when such cells are cooled as described herein. For instance, during treatment by cooling as described herein, the targeted adipose tissue may experience a restriction in blood supply and thus be starved of oxygen due to isolation as a result of applied pressure, cooling which may affect vasoconstriction in the cooled tissue, or the like. In addition to the ischemic damage caused by oxygen starvation and the buildup of metabolic waste products in the tissue during the period of restricted blood flow, restoration of blood flow after cooling treatment may additionally produce reperfusion injury to the adipocytes due to inflammation and oxidative damage that is known to occur when oxygenated blood is restored to tissue that has undergone a period of ischemia. This type of injury may be accelerated by exposing the adipocytes to an energy source (via, e.g., thermal, electrical, chemical, mechanical, acoustic, or other means) or otherwise increasing the blood flow rate in connection with or after cooling treatment as described herein. Increasing vasoconstriction in such adipose tissue by, e.g., various mechanical means (e.g., application of pressure or massage), chemical means or certain cooling conditions, as well as the local introduction of oxygen radical-forming compounds to stimulate inflammation and/or leukocyte activity in adipose tissue may also contribute to accelerating injury to such cells. Other yet-to-be understood mechanisms of injury may exist.
In addition to the apoptotic mechanisms involved in lipid-rich cell death, local cold exposure is also believed to induce lipolysis (i.e., fat metabolism) of lipid-rich cells and has been shown to enhance existing lipolysis which serves to further increase the reduction in subcutaneous lipid-rich cells. Vallerand, A. L., Zamecnik. J., Jones, P. J. H., Jacobs, I. “Cold Stress Increases Lipolysis, FFA Ra and TG/FFA Cycling in Humans” Aviation, Space and Environmental Medicine 70, 42-50 (1999).
One expected advantage of the foregoing techniques is that the subcutaneous lipid-rich cells in the target region can be reduced generally without collateral damage to non-lipid-rich cells in the same region. In general, lipid-rich cells can be affected at low temperatures that do not affect non-lipid-rich cells. As a result, lipid-rich cells, such as those associated with highly localized adiposity (e.g., adiposity along the abdomen, submental adiposity, submandibular adiposity, facial adiposity, etc.), can be affected while non-lipid-rich cells (e.g., myocytes) in the same generally region are not damaged. The unaffected non-lipid-rich cells can be located underneath lipid-rich cells (e.g., cells deeper than a subcutaneous layer of fat), in the dermis, in the epidermis, and/or at other locations.
In some procedures, the treatment system 100 can remove heat from underlying tissue through the upper layers of tissue and create a thermal gradient with the coldest temperatures near the cooling surface, or surfaces, of the applicator 102 (i.e., the temperature of the upper layer(s) of the skin can be lower than that of the targeted underlying target cells). It may be challenging to reduce the temperature of the targeted cells low enough to be destructive to these target cells (e.g., induce apoptosis, cell death, etc.) while also maintaining the temperature of the upper and surface skin cells high enough so as to be protective (e.g., non-destructive). The temperature difference between these two thresholds can be small (e.g., approximately, 5° C. to about 10° C., less than 10° C., less than 15° C., etc.). Protection of the overlying cells (e.g., typically water-rich dermal and epidermal skin cells) from freeze damage during dermatological and related aesthetic procedures that involve sustained exposure to cold temperatures may include improving the freeze tolerance and/or freeze avoidance of these skin cells by using, for example, cryoprotectants for inhibiting or preventing such freeze damage.
Tissue can be rapidly rewarmed as soon as practicable after a freeze event has occurred to limit, reduce, or prevent damage and adverse side effects associated with the freeze event. After freezing begins, tissue can be rapidly warmed as soon as possible to minimize or limit damage to tissue, such as the epidermis. In some procedures, tissue is partially or completely frozen for a predetermined period of time and then warmed. According to one embodiment, an applicator can warm shallow tissue using, for example, thermoelectric elements in the device. Thermoelectric elements can include Peltier devices capable of operating to establish a desired temperature (or temperature profile) along the surface. In other embodiments, the applicator outputs energy to warm tissue. For example, the applicator has electrodes that output radiofrequency energy for warming tissue. In some procedures, the applicator can be warmed at a rate of about 1° C./s, 2° C./s, 2.5° C./s, 3° C./s, 5° C./s, or other rate selected to thaw frozen tissue after the tissue has been partially or completely frozen for about 10 seconds, 30 seconds, 1 minute, 2 minutes, 5 minutes, 10 minutes, or other suitable length of time.
The liner assembly 117 is configured to line a temperature-controlled three-dimensional conductive cup 95 (“cup 95”), which conductively cools tissue occupying a tissue-receiving cavity 91. The liner assembly 117 can include a flexible liner 119 that lines the cup 95. A vacuum can be drawn through an opening 122 in the liner 119 to draw tissue into and securely hold tissue in the tissue-receiving cavity 91. After establishing thermal contact between the tissue and the cup 95, the base unit 103 can cool/heat the retained tissue. Upon completion of the cryotherapy procedure, the applicator 102 can release the tissue (e.g., by reducing or stopping the vacuum) and can be used at another treatment site.
Most or substantially all of the skin surface of the volume of tissue in a cavity 91 is in thermal contact with the cup 95. The vacuum can be used to apply a generally uniform pressure to the subject's skin in the cavity 91. In some procedures, the tissue can contact a relative large contact area of the cup 95 to efficiently cool the entire volume of retained tissue. A vacuum can be sufficient to keep the tissue in contact with the bottom of the cup 95 so as to keep the cavity 81 filled with tissue while limiting or minimizing pooling of blood, vascular damage (e.g., rupturing of blood vessels), bruising, and other complications with folding tissue.
The base unit 103 can include cooling units 121 in thermal communication with a temperature-controlled heat-exchanging surface 161 of the cup 95. The cooling units 121 can include, without limitation, one or more thermoelectric elements 127 (e.g., Peltier-type elements), fluid-cooled elements 129, heat-exchanging units, or combinations thereof. In a cooling mode, a fluid-cooled element 129 can cool the backside of the thermoelectric elements 127 to keep the thermoelectric elements 127 at or below a target temperature. In a heating mode, the fluid-cooled element 129 can heat the backside of the thermoelectric elements 127 to keep the thermoelectric elements 127 at or above a target temperature. In some embodiments, the cooling units 121 include only fluid-cooled elements or only non-fluid cooled thermoelectric elements. The cooling unit 121 can be coupled to, incorporated into, or part of the cup 95. In some embodiments, the thermoelectric elements 121 can be embedded or otherwise disposed in the cup 95 to reduce the distance from the tissue to the thermoelectric elements.
Although the illustrated embodiment has two thermoelectric elements 121, it can have any desired number of thermoelectric elements. The number, positions, and operating temperatures of the cooling units 121 can be selected based on cooling/heating suitable for treatment. The configurations and components of the cooling units 121 can be selected based on the desired power consumption and target temperatures.
Referring again to
The connector 104 can also include one or more electrical lines 112 for providing power to the applicator 102 and one or more control lines 116 for providing communication between the control module 106 (
The control module 106 can include a fluid system 105 (illustrated in phantom line), a power supply 110 (illustrated in phantom line), and a controller 114 carried by a housing 124 with wheels 126. The fluid system 105 can include a fluid chamber and a refrigeration unit, a cooling tower, a thermoelectric chiller, heaters, or any other device capable of controlling the temperature of coolant in the fluid chamber. The coolant can be continuously or intermittently delivered to the applicator 102 via the supply fluid line 180a (
A pressurization device 123 can provide suction to the applicator 102 via the vacuum line 125 (
The power supply 110 can provide a direct current voltage for powering electrical elements of the applicator 102 via the line 112 (
The cup 95 can include sidewalls 260a, 260b and a bottom 262. A positive draft angle of the sidewalls 260a, 260b can be increased or decreased to decrease or increase, respectively, the vacuum level needed to fill the cavity 91 with tissue. A shown in
The cavity 91 can have a substantially uniform depth along most of longitudinal axis (e.g., longitudinal axis 264 of
Referring again to
Sensors 268 can be temperature sensors, such as thermistors, positioned to detect temperature changes associated with warm tissue being drawn into and/or located in the cup 95. A control module (e.g., control module 106 of
Sensor feedback can be collected in real-time and used in concert with treatment administration to efficaciously target specific tissue. The sensor measurements can also indicate other changes or anomalies that can occur during treatment administration. For example, an increase in temperature detected by the sensors 268 can indicate either a freezing event at the skin or movement of the applicator 102. An operator can inspect the subject's skin and/or applicator 102 in response to a detected increase in temperature. Methods and systems for collection of feedback data and monitoring of temperature measurements are described in commonly assigned U.S. Pat. No. 8,285,390.
The base unit 103 can also include an integrated controller with an input/output device 271 (e.g., a U/I touchpad) used by an operator to control operation the applicator 102. The input/output device 271 can include buttons, switches, screens, or the like and display information. The displayed information can include treatment plan information, sensor readings (e.g., skin temperatures, cup temperatures, etc.), vacuum level, and so forth.
The mouth 152 can include a contoured lip 270 and a body 272. The lip 270 can define an entrance 274 and can be configured to sealingly engage, for example, the subject's skin. The lip 270 can have a rounded or curved cross-sectional shape for forming airtight seals with the subject's skin and can be made, in whole or in part, of silicon, rubber, soft plastic, or other suitable highly compliant materials. The mechanical properties, thermal properties, shape, and/or dimensions of the contoured lip 270 can be selected based on, for example, whether the contoured lip 270 contacts the subject's skin, liner assembly, a cryoprotectant gel pad, or the like. The body 272 is coupled to the frame 150 and can comprise a compliant material to allow the contoured mouth 252 expand or contract. When a vacuum is initially drawn into the mouth 252, the body 272 can deform inwardly due to the vacuum. As a tissue is pulled through the mouth 252 and toward the cup 95, the body 272 can deflect outwardly.
The frame 150 can be made, in whole or in part, of metal, plastic, rubber, combinations thereof, or the like. In some embodiments, the frame 150 comprises plastic and metal stiffeners (e.g., a steel rim) and is shaped to overlie a mounting region of the cup.
Magnetic sensing can provide accurate detection without problems associated with mechanical sensors malfunctioning, even when used with cryotherapy gels (e.g., cryoprotectant gels, temperature-dependent substances, etc.). Each sensing assembly 300 can include a cap 302 and a magnetic element 304. When the cap 302 is installed, its orientation with respect to the frame 150 can indicate information about the head 92. The magnetic element 304 can be sensed by the base unit 103 to obtain information about the presence of the head 92, position of the head 92, information about the head 92 (e.g., type of head) and so forth. Information about the type of head being used can be communicated by the treatment system 100 to its manufacturer so the manufacturer can track usage of various heads and track any failures or treatment malfunctions or treatment parameters and treatment results associated with any head to better track and improve product performance. Once the contoured head 92 is installed, one or more sensors, detectors, readers of the base unit can determine the position of the magnetic element 304, which can correspond and communicate the type of head being used and optionally other information associated with or regarding the head being used. In various embodiments, the head 92 can include, without limitation, labels, barcodes, tags (e.g., radio frequency identification tags), or other devices capable of being read by, for example, a label reader, a barcode reader, communication device (e.g., sensing assemblies, transmitters, tags, etc.), or other component of the applicator 102.
Referring now to
During a treatment session, contoured heads, line assemblies, and other components can be quickly replaced any number of times. Other types of heads, contours, and engagement features can be attached to the base unit 103. For example, contour elements disclosed in U.S. Publication 2010/0280582 can be used with the base unit 103, which may have magnets or other alignment features and can provide desired sealing, including generally air-tight seal cincturing. U.S. Publication 2010/0280582 is incorporated by reference in its entirety.
The liner 119 has a patient-contact surface 350 (
Referring again to
The base unit 103 can suck the liner 119 into the cavity 91 (indicated by arrow 407) and then against the conductive surface 161. Because the liner 119 is positioned directly over the cavity 91, it deforms less than liners or sleeved applied to the outside of applicators. As shown in
The liner 119 can overlie most or substantially the entire thermally conductive surface 161. In some procedures, the liner 119 covers all of the exposed surfaces of the cup 95 to prevent any contact between the patient and the cup 95. The liner 119 can be perforated to establish fluid communication between the base unit 103 and the tissue cavity 91. For example, one or more holes (e.g., opening 122 shown in
The liner 119 can remain securely coupled to the cup 95 throughout one or more treatment protocols, which may include repeatedly drawing tissue into the applicator, applying the applicator to multiple treatment sites, etc. Liner assemblies can include films, sheets, sleeves, or other components suitable for defining an interface surface to prevent direct contact between surfaces of the applicator and the subject's skin to reduce the likelihood of cross-contamination between patients, minimize cleaning requirements, etc. Exemplary protective liners can be sheets, sleeves, or other components constructed from latex, rubber, nylon, Kevlar®, or other substantially impermeable or semi-permeable material. For example, the liner 119 can be a latex sheet coated with a pressure-sensitive adhesive. Further details regarding a patient protection device may be found in U.S. Patent Publication No. 2008/0077201. In some procedures, a liner or protective sleeve may be positioned between an absorbent and the applicator to shield the applicator and to provide a sanitary barrier that is, in some embodiments, inexpensive and thus disposable. After installing the liner assembly 117, gel traps, filters, valves, and other components can be installed to keep applied substances (e.g., coupling gels, cryoprotectants, etc.) from being sucked into and/or through the base unit 103. In some embodiments, the liner 119 is configured to allow air to pass when drawing a vacuum and to restrict passage of a gel.
The geometries of the contoured heads can be selected to conform to a contour of a cutaneous layer. The sides, waistline, and other features of the contoured heads can be selected to facilitate conformation of heads to the contours of individual target areas. For example, the shape of a typical human torso may vary between having a relative large radius of curvature, e.g., on the stomach or back, and having a relatively small radius of curvature, e.g., on the abdominal sides. Moreover, the size of a head having an approximately consistent curvature may vary. Accordingly, an advantage of the present disclosure is the capability to provide flexible contour regions, lips, non-planar frames, etc. with various geometries, e.g., shapes and sizes, to suitably conform to the cutaneous contours of individual target areas. The heads may be fitted to individual lipid-rich cell deposits to achieve an approximately air-tight seal, achieve the vacuum pressure for drawing tissue into an interior cavity for treatment, maintain suction to hold the tissue, massage tissue (e.g., by altering pressure levels), and use little or no force to maintain contact between an applicator and a patient.
Attaching heads to base units creates specific contours to approximately fit tissue to be treated. The heads can be attached and detached in a plurality of combinations to achieve a desired contour for a treatment. Accordingly, a single base unit and/or umbilical cable may be combined with a set of interchangeable heads to form a wide variety of contours for treating different lipid-rich cell deposits in a cost effective manner. Further, a practitioner performing the treatment can demonstrate their expertise to the patient by tailoring the applicator contour to the specific body parts being treated. In this manner, the patient understands that their treatment is customized to their body for better comfort and for better treatment results.
Embodiments according to the present disclosure may provide one or more additional advantages. For example, the size, shapes, and other physical properties of the base units, liner assemblies, sealing members, gaskets, contoured heads, and components of the applicators may be selected to accommodate a heat removal sources (e.g., thermal devices, cooling devices, etc.) that may be used/reused with individual applicators. Modifications to flexible portions of individual applicators may enable the use of a standard heat removal source and accommodate different contours of individual cutaneous layers. In turn, this may make it possible to reuse base units, sealing members, liners, and/or contoured heads for different treatments. The rigid portions of the applicators (e.g., edge or mounting region of base unit), which are relatively stiff with respect to the flexible portions, provide an attachment point for heat removal sources that may resist bowing into the interior cavity and possibly separating from the heat removal sources when a vacuum (including a partial vacuum) is drawn in the applicators. Disposing temperature sensors inside the applicators, along temperature-controlled surfaces, within contoured heads, along liner assemblies, etc. may more accurately measure the temperature of skin surface, subcutaneous tissue, and so forth. The flexible portions of the applicator (e.g., flexible mouth) also allows some compliance to different subject body contours or geometries.
At block 702, the contoured head 92 and/or liner assembly 117 can be installed. As discussed in connection with
At block 704, the liner 119 can be applied to the conductive surface 161 of the cup 95 as discussed in connection with
At block 706, the liner 119 can be adhered to the conductive surface 161 and perforated to allow a vacuum to be drawn in the tissue-receiving cavity 91. Once the liner 119 overlays the cup 95, the applicator 102 can be applied to the treatment site.
At block 708, the mouth 152 can be held against the subject while the pressurization device 123 (
In some treatments, tissue can be drawn into the tissue-receiving cavity 91 such that substantially all of the skin surface within the cavity 91 overlies the conductive surface 161. For example, 90%, 95%, 95%, or more of the surface area of the skin located in the cavity 91 can overlie the conductive surface 161. The size of the vacuum ports can be increased or decreased to decrease or increase the area of the conductive surface 161.
After a sufficient amount of tissue fills most or all of the cavity 91, the tissue is cooled/heated. The pressure level (e.g., vacuum level) can be controlled to comfortably hold the tissue within the applicator 102. During cooling/heating, the tissue can fill substantially the entire cavity 91. In various embodiments, the tissue can occupy at least 70%, 80%, 90%, or 95% of the volume of the cavity 91 to avoid or minimize air pockets that may impair heat transfer. Blood flow through the dermis and subcutaneous layer of the tissue is a heat source that counteracts the cooling of the targeted tissue (e.g., sub-dermal fat). If the blood flow is not reduced, cooling the subcutaneous tissues would require not only removing the specific heat of the tissues but also that of the blood circulating through the tissues. Thus, reducing or eliminating blood flow through the tissue by increasing the vacuum can improve the efficiency of cooling and avoid excessive heat loss from the dermis and epidermis.
The conductive surface 161 can thermally contact an area of the subject's skin equal to or less than about 20 cm2, 40 cm2, 80 cm2, 100 cm2, 140 cm2, 160 cm2, 180 cm2, 200 cm2, 300 cm2, or other suitable area. For example, the temperature-controlled surface area of the cooling cup 95 can be, for example, equal to or less than 20 cm2, 40 cm2, 80 cm2, 100 cm2, 140 cm2, 160 cm2, 180 cm2, 200 cm2, 300 cm2, or another suitable area. The temperature-controlled conductive surface 161 can be cooled to a temperature equal to or less than a selected temperature (e.g., 5° C., 0° C., −2° C., −5° C., −7° C., −10° C., −15° C., −20° C., −25° C., etc.) to cool most of the skin surface of the retained tissue. In one embodiment, most of a heat-exchanging surface 161 can be cooled to a temperature equal to or less than about 0° C., −2° C., −5° C., −10° C., or −15° C.
At block 710, the applicator 102 can hold the tissue in thermal contact with the liner assembly 117 and cup 95. Heat from the tissue can be conductively transferred through the liner assembly 117 to the cooled surface 161 such that heat flows across substantially all of the applicator/skin interface. The cup 95 can be designed for rapid cooling and/or heating to, for example, reduce treatment times and/or produce generally flat temperature profiles over the heat-exchanging surface 161 or a portion thereof. Because the subject's body heat can be rapidly conducted to the cup 95, the cooled skin can be kept at a generally flat temperature profile (e.g., ±3° C. of a target temperature) even though regions of the skin, or underlying tissue, may experience different amounts of blood flow. Because non-lipid-rich cells usually can withstand colder temperatures better than lipid-rich cells, the subcutaneous lipid-rich cells can be injured selectively while maintaining the non-lipid-rich cells (e.g., non-lipid-rich cells in the dermis and epidermis). Accordingly, subcutaneous lipid-rich cells in a subcutaneous layer can be cooled an amount sufficient to be biologically effective in affecting (e.g., damaging and/or reducing) such lipid-rich cells without affecting non-target cells to the same or greater extent.
In contrast to invasive procedures in which coolant is injected directly into targeted tissue, each of the sidewalls 260a, 260b and bottom 262 (
Although the illustrated applicator 102 of
Other elements, materials, components (e.g., gel pads, absorbents, etc.) can be located between the skin and the applicators. U.S. Pub. No. 2007/0255362 and U.S. Patent Publication No. 2008/0077201 and U.S. application Ser. No. 14/610,807 disclose components, materials (e.g., coupling gels, cryoprotectants, compositions, etc.), and elements (e.g., coupling devices, liners/protective sleeves, absorbents, etc.) that can be placed between the skin and the applicator.
The control module 106 (
The control module 106 (
It will be appreciated that while a region of the body has been cooled or heated to the target temperature, in actuality that region of the body may be close but not equal to the target temperature, e.g., because of the body's natural heating and cooling variations. Thus, although the applicator 102 may attempt to heat or cool the target tissue to the target temperature or to provide a target heat flux, the sensors 268 (
The treatment procedures disclosed herein can also involve use of cryoprotectant between the applicator and skin. The cryoprotectant can be a freezing point temperature depressant that may additionally include a thickening agent, a pH buffer, a humectant, a surfactant, and/or other additives. The temperature depressant may include, for example, polypropylene glycol (PPG), polyethylene glycol (PEG), dimethyl sulfoxide (DMSO), or other suitable alcohol compounds. In a particular embodiment, a cryoprotectant may include about 30% polypropylene glycol, about 30% glycerin (a humectant), and about 40% ethanol. In another embodiment, a cryoprotectant may include about 40% propylene glycol, about 0.8% hydroxyethylcellulose (a thickening agent), and about 59.2% water. In a further embodiment, a cryoprotectant may include about 50% polypropylene glycol, about 40% glycerin, and about 10% ethanol. Other cryoprotectants or agents can also be used and can be carried by a cotton pad or other element. U.S. application Ser. No. 14/610,807 is incorporated by reference in its entirety and discloses various compositions that can be used as cryoprotectants.
It may take a few days to a few weeks, or longer, for the adipocytes to break down and be absorbed. A significant decrease in fat thickness may occur gradually over 1-3 months following treatment. Additional treatments can be performed until a desired result is achieved. For example, one or more treatments can be performed to substantially reduce (e.g., visibly reduce) or eliminate targeted tissue.
As illustrated in
In operation, the input module 808 accepts an operator input 819 via the one or more input devices, and communicates the accepted information or selections to other components for further processing. The database module 810 organizes records, including patient records, treatment data sets, treatment profiles and operating records and other operator activities, and facilitates storing and retrieving of these records to and from a data storage device (e.g., internal memory 802, an external database, etc.). Any type of database organization can be utilized, including a flat file system, hierarchical database, relational database, distributed database, etc.
In the illustrated example, the process module 812 can generate control variables based on sensor readings 818 from sensors and/or other data sources, and the output module 814 can communicate operator input to external computing devices and control variables to the controller. The display module 816 can be configured to convert and transmit processing parameters, sensor readings 818, output signals 820, input data, treatment profiles and prescribed operational parameters through one or more connected display devices, such as a display screen 118 (
In various embodiments, the processor 801 can be a standard central processing unit or a secure processor. Secure processors can be special-purpose processors (e.g., reduced instruction set processor) that can withstand sophisticated attacks that attempt to extract data or programming logic. The secure processors may not have debugging pins that enable an external debugger to monitor the secure processor's execution or registers. In other embodiments, the system may employ a secure field programmable gate array, a smartcard, or other secure devices.
The memory 802 can be standard memory, secure memory, or a combination of both memory types. By employing a secure processor and/or secure memory, the system can ensure that data and instructions are both highly secure and sensitive operations such as decryption are shielded from observation. In various embodiments, the memory 802 can be flash memory, secure serial EEPROM, secure field programmable gate array, or secure application-specific integrated circuit. The memory 802 can store instructions for causing the applicators to cool/heat tissue, pressurization devices to draw a vacuum, or other acts disclosed herein. In one embodiment, the memory 802 stores instructions executable by the controller 790 for the thermal device to sufficiently cool conductive cups disclosed herein such that submental vacuum applicators non-invasively cool the subcutaneous lipid-rich cells to a desired temperature, such as a temperature less than about 0° C. In some embodiments, the memory 802 can contain liner installation or draw instructions for causing the liner to drawn into a conductive cup, tissue draw instructions for causing the applicator to draw tissue into the applicator, treatment instructions for heating/cooling tissue, tissue release instructions for releasing tissue, and instructions for monitoring treatment. For example, the liner installation or draw instructions can be executed by the controller 790 to command the pressurization device 123 to suck the liner against a conductive surface of the conductive cup.
The input/output device 118 can include, without limitation, a touchscreen, a keyboard, a mouse, a stylus, a push button, a switch, a potentiometer, a scanner, an audio component such as a microphone, or any other device suitable for accepting user input and can also include one or more video monitor, a medium reader, an audio device such as a speaker, any combination thereof, and any other device or devices suitable for providing user feedback. For example, if an applicator moves an undesirable amount during a treatment session, the input/output device 803 can alert the subject and/or operator via an audible alarm. The input/output device 118 can be a touch screen that functions as both an input device and an output device. The control panel can include visual indicator devices or controls (e.g., indicator lights, numerical displays, etc.) and/or audio indicator devices or controls. The control panel may be a component separate from the input/output device 118 and/or output device 120, may be integrated applicators, may be partially integrated with one or more of the devices, may be in another location, and so on. In alternative embodiments, the controller 114 can be contained in, attached to, or integrated with the applicators. Further details with respect to components and/or operation of applicators, control modules (e.g., treatment units), and other components may be found in commonly-assigned U.S. Patent Publication No. 2008/0287839.
The controller 790 can include any processor, Programmable Logic Controller, Distributed Control System, secure processor, and the like. A secure processor can be implemented as an integrated circuit with access-controlled physical interfaces; tamper resistant containment; means of detecting and responding to physical tampering; secure storage; and shielded execution of computer-executable instructions. Some secure processors also provide cryptographic accelerator circuitry. Suitable computing environments and other computing devices and user interfaces are described in commonly assigned U.S. Pat. No. 8,275,442, entitled “TREATMENT PLANNING SYSTEMS AND METHODS FOR BODY CONTOURING APPLICATIONS,” which is incorporated herein in its entirety by reference.
The treatment systems, applicators, and methods of treatment can be used reduce adipose tissue or treat subcutaneous tissue, acne, hyperhidrosis, wrinkles, structures (e.g., structures in the epidermis, dermis, subcutaneous fat, muscle, nerve tissue, etc.), and so on. Systems, components, and techniques for reducing subcutaneous adipose tissue are disclosed in U.S. Pat. No. 7,367,341 titled “METHODS AND DEVICES FOR SELECTIVE DISRUPTION OF FATTY TISSUE BY CONTROLLED COOLING” to Anderson et al., U.S. Patent Publication No. US 2005/0251120 titled “METHODS AND DEVICES FOR DETECTION AND CONTROL OF SELECTIVE DISRUPTION OF FATTY TISSUE BY CONTROLLED COOLING” to Anderson et al., and U.S. Patent Publication No. 2007/0255362 titled “CRYOPROTECTANT FOR USE WITH A TREATMENT DEVICE FOR IMPROVED COOLING OF SUBCUTANEOUS LIPID-RICH CELLS,” the disclosures of which are incorporated herein by reference in their entireties. Vacuum applicators can stretch, stress, and/or mechanically alter skin to increase damage and fibrosis in the skin, affect glands, control freeze events (including initiating freeze events), etc. Methods for cooling tissue and related devices and systems in accordance with embodiments of the present invention can at least partially address one or more problems associated with conventional technologies as discussed above and/or other problems whether or not such problems are stated herein.
Unless the context clearly requires otherwise, throughout the description, the words “comprise,” “comprising,” and the like are to be construed in an inclusive sense as opposed to an exclusive or exhaustive sense; that is to say, in a sense of “including, but not limited to.” Words using the singular or plural number also include the plural or singular number, respectively. Use of the word “or” in reference to a list of two or more items covers all of the following interpretations of the word: any of the items in the list, all of the items in the list, and any combination of the items in the list. Furthermore, the phrase “at least one of A, B, and C, etc.” is intended in the sense one having skill in the art would understand the convention (e.g., “a system having at least one of A, B, and C” would include but not be limited to systems that have A alone, B alone, C alone, A and B together, A and C together, B and C together, and/or A, B, and C together, etc.). In those instances where a convention analogous to “at least one of A, B, or C, etc.” is used, in general such a construction is intended in the sense one having skill in the art would understand the convention (e.g., “a system having at least one of A, B, or C” would include but not be limited to systems that have A alone, B alone, C alone, A and B together, A and C together, B and C together, and/or A, B, and C together, etc.).
Any patents, applications and other references, including any that may be listed in accompanying filing papers, are incorporated herein by reference. Aspects of the described technology can be modified, if necessary, to employ the systems, functions, and concepts of the various references described above to provide yet further embodiments. These and other changes can be made in light of the above Detailed Description. While the above description details certain embodiments and describes the best mode contemplated, no matter how detailed, various changes can be made. Implementation details may vary considerably, while still being encompassed by the technology disclosed herein. As noted above, particular terminology used when describing certain features or aspects of the technology should not be taken to imply that the terminology is being redefined herein to be restricted to any specific characteristics, features, or aspects of the technology with which that terminology is associated.
The present application claims the benefit of and priority under 35 U.S.C. § 119(e) to U.S. Provisional Patent Application No. 62/297,054, filed Feb. 18, 2016, which is incorporated herein by reference in its entirety.
| Number | Name | Date | Kind |
|---|---|---|---|
| 681806 | Mignault et al. | Sep 1901 | A |
| 889810 | Robinson et al. | Jun 1908 | A |
| 2516491 | Swastek | Jul 1950 | A |
| 2521780 | Dodd et al. | Sep 1950 | A |
| 2726658 | Chessey | Dec 1955 | A |
| 2766619 | Tribus et al. | Oct 1956 | A |
| 2851602 | Cramwinckel et al. | Sep 1958 | A |
| 3093135 | Hirschhorn | Jun 1963 | A |
| 3132688 | Nowak | May 1964 | A |
| 3133539 | Eidus et al. | May 1964 | A |
| 3282267 | Eidus | Nov 1966 | A |
| 3502080 | Hirschhorn | Mar 1970 | A |
| 3566871 | Richter et al. | Mar 1971 | A |
| 3587577 | Zubkov et al. | Jun 1971 | A |
| 3591645 | Selwitz | Jul 1971 | A |
| 3703897 | Mack et al. | Nov 1972 | A |
| 3710784 | Taylor | Jan 1973 | A |
| 3786814 | Armao | Jan 1974 | A |
| 3827436 | Andera et al. | Aug 1974 | A |
| 3942519 | Shock | Mar 1976 | A |
| 3948269 | Zimmer | Apr 1976 | A |
| 3986385 | Johnston et al. | Oct 1976 | A |
| 3993053 | Grossan | Nov 1976 | A |
| 4002221 | Buchalter | Jan 1977 | A |
| 4026299 | Sauder | May 1977 | A |
| 4140130 | Storm | Feb 1979 | A |
| 4149529 | Copeland et al. | Apr 1979 | A |
| 4178429 | Scheffer | Dec 1979 | A |
| 4202336 | Van Gerven | May 1980 | A |
| 4266043 | Fujii et al. | May 1981 | A |
| 4269068 | Molina | May 1981 | A |
| 4381009 | Del Bon | Apr 1983 | A |
| 4396011 | Mack et al. | Aug 1983 | A |
| 4459854 | Richardson et al. | Jul 1984 | A |
| 4470263 | Lehovec et al. | Sep 1984 | A |
| 4483341 | Witteles | Nov 1984 | A |
| 4528979 | Marchenko et al. | Jul 1985 | A |
| 4531524 | Mioduski | Jul 1985 | A |
| 4548212 | Leung | Oct 1985 | A |
| 4555313 | Duchane et al. | Nov 1985 | A |
| 4585002 | Kissin | Apr 1986 | A |
| 4603076 | Bowditch et al. | Jul 1986 | A |
| 4614191 | Perler et al. | Sep 1986 | A |
| 4644955 | Mioduski | Feb 1987 | A |
| 4664110 | Schanzlin | May 1987 | A |
| 4700701 | Montaldi | Oct 1987 | A |
| 4718429 | Smidt | Jan 1988 | A |
| 4741338 | Miyamae | May 1988 | A |
| 4764463 | Mason et al. | Aug 1988 | A |
| 4802475 | Weshahy | Feb 1989 | A |
| 4832022 | Tjulkov et al. | May 1989 | A |
| 4846176 | Golden | Jul 1989 | A |
| 4850340 | Onishi | Jul 1989 | A |
| 4869250 | Bitterly | Sep 1989 | A |
| 4880564 | Abel et al. | Nov 1989 | A |
| 4905697 | Heggs et al. | Mar 1990 | A |
| 4906463 | Cleary et al. | Mar 1990 | A |
| 4930317 | Klein | Jun 1990 | A |
| 4935345 | Guilbeau et al. | Jun 1990 | A |
| 4961422 | Marchosky et al. | Oct 1990 | A |
| 4962761 | Golden | Oct 1990 | A |
| 4990144 | Blott et al. | Feb 1991 | A |
| 5007433 | Hermsdoerffer et al. | Apr 1991 | A |
| 5018521 | Campbell et al. | May 1991 | A |
| 5024650 | Hagiwara et al. | Jun 1991 | A |
| 5065752 | Sessions et al. | Nov 1991 | A |
| 5069208 | Noppel et al. | Dec 1991 | A |
| 5084671 | Miyata et al. | Jan 1992 | A |
| 5108390 | Potocky et al. | Apr 1992 | A |
| 5119674 | Nielsen | Jun 1992 | A |
| 5139496 | Hed | Aug 1992 | A |
| 5143063 | Fellner | Sep 1992 | A |
| 5148804 | Hill et al. | Sep 1992 | A |
| 5158070 | Dory | Oct 1992 | A |
| 5160312 | Voelkel | Nov 1992 | A |
| 5169384 | Bosniak et al. | Dec 1992 | A |
| 5197466 | Marchosky et al. | Mar 1993 | A |
| 5207674 | Hamilton | May 1993 | A |
| 5221726 | Dabi et al. | Jun 1993 | A |
| 5264234 | Windhab et al. | Nov 1993 | A |
| 5277030 | Miller | Jan 1994 | A |
| 5314423 | Seney et al. | May 1994 | A |
| 5327886 | Chiu | Jul 1994 | A |
| 5330745 | Mcdow et al. | Jul 1994 | A |
| 5333460 | Lewis et al. | Aug 1994 | A |
| 5334131 | Omandam et al. | Aug 1994 | A |
| 5336616 | Livesey et al. | Aug 1994 | A |
| 5339541 | Owens | Aug 1994 | A |
| 5342617 | Gold et al. | Aug 1994 | A |
| 5351677 | Kami et al. | Oct 1994 | A |
| 5358467 | Milstein et al. | Oct 1994 | A |
| 5362966 | Rosenthal et al. | Nov 1994 | A |
| 5363347 | Nguyen | Nov 1994 | A |
| 5372608 | Johnson | Dec 1994 | A |
| 5386837 | Sterzer | Feb 1995 | A |
| 5411541 | Bell et al. | May 1995 | A |
| 5427772 | Hagan et al. | Jun 1995 | A |
| 5433717 | Rubinsky et al. | Jul 1995 | A |
| 5456703 | Beeuwkes, III et al. | Oct 1995 | A |
| 5472416 | Blugerman et al. | Dec 1995 | A |
| 5486207 | Mahawili | Jan 1996 | A |
| 5497596 | Zatkulak | Mar 1996 | A |
| 5501655 | Rolt et al. | Mar 1996 | A |
| 5505726 | Meserol | Apr 1996 | A |
| 5505730 | Edwards et al. | Apr 1996 | A |
| 5507790 | Weiss | Apr 1996 | A |
| 5514105 | Goodman, Jr. et al. | May 1996 | A |
| 5514170 | Mauch | May 1996 | A |
| 5516505 | Mcdow | May 1996 | A |
| 5531742 | Barken | Jul 1996 | A |
| 5562604 | Yablon et al. | Oct 1996 | A |
| 5571801 | Segall et al. | Nov 1996 | A |
| 5575812 | Owens et al. | Nov 1996 | A |
| 5603221 | Maytal | Feb 1997 | A |
| 5628769 | Saringer | May 1997 | A |
| 5634890 | Morris | Jun 1997 | A |
| 5634940 | Panyard | Jun 1997 | A |
| 5647051 | Neer | Jul 1997 | A |
| 5647868 | Chinn | Jul 1997 | A |
| 5650450 | Lovette et al. | Jul 1997 | A |
| 5651773 | Perry et al. | Jul 1997 | A |
| 5654279 | Rubinsky et al. | Aug 1997 | A |
| 5654546 | Lindsay et al. | Aug 1997 | A |
| 5660836 | Knowlton et al. | Aug 1997 | A |
| 5665053 | Jacobs | Sep 1997 | A |
| 5672172 | Zupkas | Sep 1997 | A |
| 5700284 | Owens et al. | Dec 1997 | A |
| 5725483 | Podolsky | Mar 1998 | A |
| 5733280 | Avitall | Mar 1998 | A |
| 5741248 | Stern et al. | Apr 1998 | A |
| 5746702 | Gelfgat et al. | May 1998 | A |
| 5746736 | Tankovich | May 1998 | A |
| 5755663 | Larsen et al. | May 1998 | A |
| 5755753 | Knowlton et al. | May 1998 | A |
| 5755755 | Panyard | May 1998 | A |
| 5759182 | Varney et al. | Jun 1998 | A |
| 5759764 | Polovina et al. | Jun 1998 | A |
| 5769879 | Richards et al. | Jun 1998 | A |
| 5785955 | Fischer | Jul 1998 | A |
| 5792080 | Ookawa et al. | Aug 1998 | A |
| 5800490 | Patz et al. | Sep 1998 | A |
| 5814040 | Nelson et al. | Sep 1998 | A |
| 5817050 | Klein et al. | Oct 1998 | A |
| 5817149 | Owens et al. | Oct 1998 | A |
| 5817150 | Owens et al. | Oct 1998 | A |
| 5830208 | Muller et al. | Nov 1998 | A |
| 5833685 | Tortal et al. | Nov 1998 | A |
| 5844013 | Kenndoff et al. | Dec 1998 | A |
| 5865841 | Kolen et al. | Feb 1999 | A |
| 5871524 | Knowlton | Feb 1999 | A |
| 5871526 | Gibbs et al. | Feb 1999 | A |
| 5885211 | Eppstein et al. | Mar 1999 | A |
| 5891617 | Watson et al. | Apr 1999 | A |
| 5895418 | Saringer | Apr 1999 | A |
| 5901707 | Goncalves | May 1999 | A |
| 5902256 | Benaron | May 1999 | A |
| 5919219 | Knowlton et al. | Jul 1999 | A |
| 5944748 | Mager et al. | Aug 1999 | A |
| 5948011 | Knowlton et al. | Sep 1999 | A |
| 5954680 | Augustine et al. | Sep 1999 | A |
| 5964092 | Tozuka et al. | Oct 1999 | A |
| 5964749 | Eckhouse et al. | Oct 1999 | A |
| 5967976 | Larsen et al. | Oct 1999 | A |
| 5980561 | Kolen et al. | Nov 1999 | A |
| 5986167 | Arteman et al. | Nov 1999 | A |
| 5989286 | Owens et al. | Nov 1999 | A |
| 5997530 | Nelson et al. | Dec 1999 | A |
| 6017337 | Pira | Jan 2000 | A |
| 6023932 | Johnston | Feb 2000 | A |
| 6032675 | Rubinsky | Mar 2000 | A |
| 6039694 | Larson et al. | Mar 2000 | A |
| 6041787 | Rubinsky | Mar 2000 | A |
| 6047215 | McClure et al. | Apr 2000 | A |
| 6049927 | Thomas et al. | Apr 2000 | A |
| 6051159 | Hao et al. | Apr 2000 | A |
| 6071239 | Cribbs et al. | Jun 2000 | A |
| 6074415 | Der Ovanesian | Jun 2000 | A |
| 6093230 | Johnson et al. | Jul 2000 | A |
| 6102885 | Bass | Aug 2000 | A |
| 6104952 | Tu et al. | Aug 2000 | A |
| 6104959 | Spertell et al. | Aug 2000 | A |
| 6106517 | Zupkas | Aug 2000 | A |
| 6113558 | Rosenschein et al. | Sep 2000 | A |
| 6113559 | Klopotek | Sep 2000 | A |
| 6113626 | Clifton et al. | Sep 2000 | A |
| 6120519 | Weber et al. | Sep 2000 | A |
| 6139544 | Mikus et al. | Oct 2000 | A |
| 6150148 | Nanda et al. | Nov 2000 | A |
| 6151735 | Koby et al. | Nov 2000 | A |
| 6152952 | Owens et al. | Nov 2000 | A |
| 6171301 | Nelson et al. | Jan 2001 | B1 |
| 6180867 | Hedengren et al. | Jan 2001 | B1 |
| 6226996 | Weber et al. | May 2001 | B1 |
| 6241753 | Knowlton | Jun 2001 | B1 |
| 6264649 | Whitcroft et al. | Jul 2001 | B1 |
| 6273884 | Altshuler et al. | Aug 2001 | B1 |
| 6290988 | Van Vilsteren et al. | Sep 2001 | B1 |
| 6311090 | Knowlton | Oct 2001 | B1 |
| 6311497 | Chung | Nov 2001 | B1 |
| 6312453 | Stefanile et al. | Nov 2001 | B1 |
| 6350276 | Knowlton | Feb 2002 | B1 |
| 6354297 | Eiseman | Mar 2002 | B1 |
| 6357907 | Cleveland et al. | Mar 2002 | B1 |
| 6375673 | Clifton et al. | Apr 2002 | B1 |
| 6377854 | Knowlton | Apr 2002 | B1 |
| 6377855 | Knowlton | Apr 2002 | B1 |
| 6381497 | Knowlton | Apr 2002 | B1 |
| 6381498 | Knowlton | Apr 2002 | B1 |
| 6387380 | Knowlton | May 2002 | B1 |
| 6401722 | Krag | Jun 2002 | B1 |
| 6405090 | Knowlton | Jun 2002 | B1 |
| 6413255 | Stern | Jul 2002 | B1 |
| 6425912 | Knowlton | Jul 2002 | B1 |
| 6426445 | Young et al. | Jul 2002 | B1 |
| 6430446 | Knowlton | Aug 2002 | B1 |
| 6430956 | Haas et al. | Aug 2002 | B1 |
| 6438424 | Knowlton | Aug 2002 | B1 |
| 6438954 | Goetz et al. | Aug 2002 | B1 |
| 6438964 | Giblin | Aug 2002 | B1 |
| 6453202 | Knowlton | Sep 2002 | B1 |
| 6458888 | Hood et al. | Oct 2002 | B1 |
| 6461378 | Knowlton | Oct 2002 | B1 |
| 6470216 | Knowlton | Oct 2002 | B1 |
| 6471693 | Carroll et al. | Oct 2002 | B1 |
| 6475211 | Chess et al. | Nov 2002 | B2 |
| 6478811 | Dobak, III et al. | Nov 2002 | B1 |
| 6494844 | Van Bladel et al. | Dec 2002 | B1 |
| 6497721 | Ginsburg et al. | Dec 2002 | B2 |
| 6508831 | Kushnir | Jan 2003 | B1 |
| 6514244 | Pope et al. | Feb 2003 | B2 |
| 6519964 | Bieberich | Feb 2003 | B2 |
| 6523354 | Tolbert | Feb 2003 | B1 |
| 6527765 | Kelman et al. | Mar 2003 | B2 |
| 6527798 | Ginsburg et al. | Mar 2003 | B2 |
| 6544248 | Bass | Apr 2003 | B1 |
| 6547811 | Becker et al. | Apr 2003 | B1 |
| 6548297 | Kuri-Harcuch et al. | Apr 2003 | B1 |
| 6551255 | Van Bladel et al. | Apr 2003 | B2 |
| 6551341 | Boylan et al. | Apr 2003 | B2 |
| 6551348 | Blalock et al. | Apr 2003 | B1 |
| 6551349 | Lasheras et al. | Apr 2003 | B2 |
| 6569189 | Augustine et al. | May 2003 | B1 |
| 6585652 | Lang et al. | Jul 2003 | B2 |
| 6592577 | Abboud et al. | Jul 2003 | B2 |
| 6605080 | Altshuler et al. | Aug 2003 | B1 |
| 6607498 | Eshel | Aug 2003 | B2 |
| 6620187 | Carson et al. | Sep 2003 | B2 |
| 6620188 | Ginsburg et al. | Sep 2003 | B1 |
| 6620189 | Machold et al. | Sep 2003 | B1 |
| 6623430 | Slayton et al. | Sep 2003 | B1 |
| 6626854 | Friedman et al. | Sep 2003 | B2 |
| 6632219 | Baranov et al. | Oct 2003 | B1 |
| 6635053 | Lalonde et al. | Oct 2003 | B1 |
| 6643535 | Damasco et al. | Nov 2003 | B2 |
| 6645162 | Friedman et al. | Nov 2003 | B2 |
| 6645229 | Matsumura et al. | Nov 2003 | B2 |
| 6645232 | Carson | Nov 2003 | B2 |
| 6648904 | Altshuler et al. | Nov 2003 | B2 |
| 6656208 | Grahn et al. | Dec 2003 | B2 |
| 6660027 | Gruszecki et al. | Dec 2003 | B2 |
| 6662054 | Kreindel et al. | Dec 2003 | B2 |
| 6682550 | Clifton et al. | Jan 2004 | B2 |
| 6685731 | Kushnir et al. | Feb 2004 | B2 |
| 6694170 | Mikus et al. | Feb 2004 | B1 |
| 6695874 | Machold et al. | Feb 2004 | B2 |
| 6697670 | Chornenky | Feb 2004 | B2 |
| 6699237 | Weber et al. | Mar 2004 | B2 |
| 6699266 | Lachenbruch et al. | Mar 2004 | B2 |
| 6699267 | Voorhees et al. | Mar 2004 | B2 |
| 6718785 | Bieberich | Apr 2004 | B2 |
| 6741895 | Gafni et al. | May 2004 | B1 |
| 6743222 | Durkin et al. | Jun 2004 | B2 |
| 6746474 | Saadat | Jun 2004 | B2 |
| 6749624 | Knowlton | Jun 2004 | B2 |
| 6753182 | Kadkade et al. | Jun 2004 | B1 |
| 6764493 | Weber et al. | Jul 2004 | B1 |
| 6764502 | Bieberich | Jul 2004 | B2 |
| 6789545 | Littrup et al. | Sep 2004 | B2 |
| 6795728 | Chornenky et al. | Sep 2004 | B2 |
| 6820961 | Johnson | Nov 2004 | B2 |
| 6821274 | McHale et al. | Nov 2004 | B2 |
| 6840955 | Ein | Jan 2005 | B2 |
| 6849075 | Bertolero et al. | Feb 2005 | B2 |
| 6878144 | Altshuler et al. | Apr 2005 | B2 |
| 6889090 | Kreindel | May 2005 | B2 |
| 6892099 | Jaafar et al. | May 2005 | B2 |
| 6904956 | Noel | Jun 2005 | B2 |
| 6918903 | Bass | Jul 2005 | B2 |
| 6927316 | Faries, Jr. et al. | Aug 2005 | B1 |
| 6942022 | Blangetti et al. | Sep 2005 | B2 |
| 6945942 | Van Bladel et al. | Sep 2005 | B2 |
| 6948903 | Ablabutyan et al. | Sep 2005 | B2 |
| 6969399 | Schock et al. | Nov 2005 | B2 |
| 7005558 | Johansson et al. | Feb 2006 | B1 |
| 7006874 | Knowlton et al. | Feb 2006 | B2 |
| 7022121 | Stern et al. | Apr 2006 | B2 |
| 7037326 | Lee | May 2006 | B2 |
| 7054685 | Dimmer et al. | May 2006 | B2 |
| 7060061 | Altshuler et al. | Jun 2006 | B2 |
| 7077858 | Fletcher et al. | Jul 2006 | B2 |
| 7081111 | Svaasand et al. | Jul 2006 | B2 |
| 7083612 | Littrup et al. | Aug 2006 | B2 |
| 7096204 | Chen et al. | Aug 2006 | B1 |
| 7112712 | Ancell | Sep 2006 | B1 |
| 7115123 | Knowlton et al. | Oct 2006 | B2 |
| 7141049 | Stern et al. | Nov 2006 | B2 |
| 7183360 | Daniel et al. | Feb 2007 | B2 |
| 7189252 | Krueger | Mar 2007 | B2 |
| 7192426 | Baust et al. | Mar 2007 | B2 |
| 7204832 | Altshuler et al. | Apr 2007 | B2 |
| 7220778 | Anderson et al. | May 2007 | B2 |
| 7229436 | Stern et al. | Jun 2007 | B2 |
| 7258674 | Cribbs et al. | Aug 2007 | B2 |
| 7267675 | Stern et al. | Sep 2007 | B2 |
| 7276058 | Altshuler et al. | Oct 2007 | B2 |
| 7318821 | Lalonde et al. | Jan 2008 | B2 |
| 7331951 | Eshel et al. | Feb 2008 | B2 |
| 7347855 | Eshel et al. | Mar 2008 | B2 |
| 7367341 | Anderson et al. | May 2008 | B2 |
| 7532201 | Quistgaard et al. | May 2009 | B2 |
| 7572268 | Babaev | Aug 2009 | B2 |
| 7604632 | Howlett et al. | Oct 2009 | B2 |
| 7613523 | Eggers et al. | Nov 2009 | B2 |
| 7615016 | Barthe et al. | Nov 2009 | B2 |
| 7713266 | Elkins et al. | May 2010 | B2 |
| 7780656 | Tankovich | Aug 2010 | B2 |
| 7799018 | Goulko | Sep 2010 | B2 |
| 7824437 | Saunders | Nov 2010 | B1 |
| 7828831 | Tanhehco et al. | Nov 2010 | B1 |
| 7850683 | Elkins et al. | Dec 2010 | B2 |
| 7854754 | Ting et al. | Dec 2010 | B2 |
| 7862558 | Elkins et al. | Jan 2011 | B2 |
| RE42277 | Jaafar et al. | Apr 2011 | E |
| 7938824 | Chornenky et al. | May 2011 | B2 |
| 7959657 | Harsy et al. | Jun 2011 | B1 |
| 7963959 | Da Silva et al. | Jun 2011 | B2 |
| 7967763 | Deem et al. | Jun 2011 | B2 |
| 7993330 | Goulko | Aug 2011 | B2 |
| 7998137 | Elkins et al. | Aug 2011 | B2 |
| RE42835 | Chornenky et al. | Oct 2011 | E |
| RE43009 | Chornenky et al. | Dec 2011 | E |
| 8133180 | Slayton et al. | Mar 2012 | B2 |
| 8133191 | Rosenberg et al. | Mar 2012 | B2 |
| 8192474 | Levinson | Jun 2012 | B2 |
| 8246611 | Paithankar et al. | Aug 2012 | B2 |
| 8275442 | Allison | Sep 2012 | B2 |
| 8285390 | Levinson et al. | Oct 2012 | B2 |
| 8333700 | Barthe et al. | Dec 2012 | B1 |
| 8337539 | Ting et al. | Dec 2012 | B2 |
| 8366622 | Slayton et al. | Feb 2013 | B2 |
| 8372130 | Young et al. | Feb 2013 | B2 |
| 8397518 | Vistakula et al. | Mar 2013 | B1 |
| 8414631 | Quisenberry et al. | Apr 2013 | B2 |
| 8433400 | Prushinskaya et al. | Apr 2013 | B2 |
| 8506486 | Slayton et al. | Aug 2013 | B2 |
| 8523775 | Barthe et al. | Sep 2013 | B2 |
| 8523791 | Castel | Sep 2013 | B2 |
| 8523927 | Levinson et al. | Sep 2013 | B2 |
| 8535228 | Slayton et al. | Sep 2013 | B2 |
| 8603073 | Allison | Dec 2013 | B2 |
| 8636665 | Slayton et al. | Jan 2014 | B2 |
| 8641622 | Barthe et al. | Feb 2014 | B2 |
| 8663112 | Slayton et al. | Mar 2014 | B2 |
| 8672848 | Slayton et al. | Mar 2014 | B2 |
| 8676332 | Fahey | Mar 2014 | B2 |
| 8690778 | Slayton et al. | Apr 2014 | B2 |
| 8690779 | Slayton et al. | Apr 2014 | B2 |
| 8690780 | Slayton et al. | Apr 2014 | B2 |
| 8702774 | Baker et al. | Apr 2014 | B2 |
| 8758215 | Legendre et al. | Jun 2014 | B2 |
| 8764693 | Graham et al. | Jul 2014 | B1 |
| 8834547 | Anderson et al. | Sep 2014 | B2 |
| 9861520 | Baker et al. | Jan 2018 | B2 |
| 20010005791 | Ginsburg et al. | Jun 2001 | A1 |
| 20010007952 | Shimizu | Jul 2001 | A1 |
| 20010023364 | Ahn | Sep 2001 | A1 |
| 20010031459 | Fahy et al. | Oct 2001 | A1 |
| 20010039439 | Elkins et al. | Nov 2001 | A1 |
| 20010045104 | Bailey, Sr. et al. | Nov 2001 | A1 |
| 20010047196 | Ginsburg et al. | Nov 2001 | A1 |
| 20020026226 | Ein | Feb 2002 | A1 |
| 20020032473 | Kushnir et al. | Mar 2002 | A1 |
| 20020042607 | Palmer et al. | Apr 2002 | A1 |
| 20020049483 | Knowlton | Apr 2002 | A1 |
| 20020058975 | Bieberich | May 2002 | A1 |
| 20020062142 | Knowlton | May 2002 | A1 |
| 20020068338 | Nanda et al. | Jun 2002 | A1 |
| 20020082668 | Ingman | Jun 2002 | A1 |
| 20020103520 | Latham | Aug 2002 | A1 |
| 20020107558 | Clifton et al. | Aug 2002 | A1 |
| 20020117293 | Campbell | Aug 2002 | A1 |
| 20020120315 | Furuno et al. | Aug 2002 | A1 |
| 20020128648 | Weber et al. | Sep 2002 | A1 |
| 20020151830 | Kahn | Oct 2002 | A1 |
| 20020151887 | Stern et al. | Oct 2002 | A1 |
| 20020156509 | Cheung | Oct 2002 | A1 |
| 20020188286 | Quijano et al. | Dec 2002 | A1 |
| 20020198518 | Mikus et al. | Dec 2002 | A1 |
| 20030032900 | Ella | Feb 2003 | A1 |
| 20030044764 | Soane et al. | Mar 2003 | A1 |
| 20030055414 | Altshuler et al. | Mar 2003 | A1 |
| 20030062040 | Lurie et al. | Apr 2003 | A1 |
| 20030069618 | Smith, III et al. | Apr 2003 | A1 |
| 20030077326 | Newton et al. | Apr 2003 | A1 |
| 20030077329 | Kipp et al. | Apr 2003 | A1 |
| 20030079488 | Bieberich | May 2003 | A1 |
| 20030100936 | Altshuler et al. | May 2003 | A1 |
| 20030109908 | Lachenbruch et al. | Jun 2003 | A1 |
| 20030109910 | Lachenbruch et al. | Jun 2003 | A1 |
| 20030109911 | Lachenbruch et al. | Jun 2003 | A1 |
| 20030109912 | Joye et al. | Jun 2003 | A1 |
| 20030114885 | Nova et al. | Jun 2003 | A1 |
| 20030120268 | Bertolero et al. | Jun 2003 | A1 |
| 20030125649 | McIntosh et al. | Jul 2003 | A1 |
| 20030187488 | Kreindel et al. | Oct 2003 | A1 |
| 20030199226 | Sommer et al. | Oct 2003 | A1 |
| 20030199859 | Altshuler et al. | Oct 2003 | A1 |
| 20030220594 | Halvorson et al. | Nov 2003 | A1 |
| 20030220635 | Knowlton et al. | Nov 2003 | A1 |
| 20030220674 | Anderson et al. | Nov 2003 | A1 |
| 20030236487 | Knowlton | Dec 2003 | A1 |
| 20040002705 | Knowlton et al. | Jan 2004 | A1 |
| 20040006328 | Anderson | Jan 2004 | A1 |
| 20040009936 | Tang et al. | Jan 2004 | A1 |
| 20040024437 | Machold et al. | Feb 2004 | A1 |
| 20040030332 | Knowlton et al. | Feb 2004 | A1 |
| 20040034341 | Altshuler et al. | Feb 2004 | A1 |
| 20040039312 | Hillstead et al. | Feb 2004 | A1 |
| 20040044384 | Leber et al. | Mar 2004 | A1 |
| 20040049178 | Abboud et al. | Mar 2004 | A1 |
| 20040073079 | Altshuler et al. | Apr 2004 | A1 |
| 20040074629 | Noel | Apr 2004 | A1 |
| 20040077977 | Ella et al. | Apr 2004 | A1 |
| 20040082886 | Timpson | Apr 2004 | A1 |
| 20040093042 | Altshuler et al. | May 2004 | A1 |
| 20040104012 | Zhou et al. | Jun 2004 | A1 |
| 20040106867 | Eshel et al. | Jun 2004 | A1 |
| 20040133251 | Altshuler et al. | Jul 2004 | A1 |
| 20040162596 | Altshuler et al. | Aug 2004 | A1 |
| 20040176667 | Mihai et al. | Sep 2004 | A1 |
| 20040186535 | Knowlton | Sep 2004 | A1 |
| 20040199226 | Shadduck | Oct 2004 | A1 |
| 20040206365 | Knowlton | Oct 2004 | A1 |
| 20040210214 | Knowlton | Oct 2004 | A1 |
| 20040210287 | Greene | Oct 2004 | A1 |
| 20040215294 | Littrup et al. | Oct 2004 | A1 |
| 20040249427 | Nabilsi et al. | Dec 2004 | A1 |
| 20040259855 | Anderson et al. | Dec 2004 | A1 |
| 20040260209 | Ella et al. | Dec 2004 | A1 |
| 20040260210 | Ella et al. | Dec 2004 | A1 |
| 20040260211 | Maalouf | Dec 2004 | A1 |
| 20050010197 | Lau et al. | Jan 2005 | A1 |
| 20050033957 | Enokida | Feb 2005 | A1 |
| 20050049526 | Baer | Mar 2005 | A1 |
| 20050049543 | Anderson et al. | Mar 2005 | A1 |
| 20050049661 | Koffroth | Mar 2005 | A1 |
| 20050113725 | Masuda | May 2005 | A1 |
| 20050143781 | Carbunaru et al. | Jun 2005 | A1 |
| 20050145372 | Noel | Jul 2005 | A1 |
| 20050149153 | Nakase et al. | Jul 2005 | A1 |
| 20050154314 | Quistgaard | Jul 2005 | A1 |
| 20050154431 | Quistgaard et al. | Jul 2005 | A1 |
| 20050159986 | Breeland et al. | Jul 2005 | A1 |
| 20050177075 | Meunier et al. | Aug 2005 | A1 |
| 20050182462 | Chornenky et al. | Aug 2005 | A1 |
| 20050187495 | Quistgaard et al. | Aug 2005 | A1 |
| 20050187597 | Vanderschuit | Aug 2005 | A1 |
| 20050203446 | Takashima | Sep 2005 | A1 |
| 20050215987 | Slatkine | Sep 2005 | A1 |
| 20050222565 | Manstein | Oct 2005 | A1 |
| 20050251117 | Anderson et al. | Nov 2005 | A1 |
| 20050251120 | Anderson et al. | Nov 2005 | A1 |
| 20050261753 | Littrup et al. | Nov 2005 | A1 |
| 20050277859 | Carlsmith et al. | Dec 2005 | A1 |
| 20050283144 | Shiono et al. | Dec 2005 | A1 |
| 20060030778 | Mendlein et al. | Feb 2006 | A1 |
| 20060035380 | Saint-Leger | Feb 2006 | A1 |
| 20060036300 | Kreindel | Feb 2006 | A1 |
| 20060041704 | Choi | Feb 2006 | A1 |
| 20060074313 | Slayton et al. | Apr 2006 | A1 |
| 20060079852 | Bubb et al. | Apr 2006 | A1 |
| 20060094988 | Tosaya et al. | May 2006 | A1 |
| 20060106836 | Masugi et al. | May 2006 | A1 |
| 20060122509 | Desilets | Jun 2006 | A1 |
| 20060188832 | McCarren | Aug 2006 | A1 |
| 20060189964 | Anderson et al. | Aug 2006 | A1 |
| 20060195168 | Dunbar et al. | Aug 2006 | A1 |
| 20060200063 | Munro et al. | Sep 2006 | A1 |
| 20060206040 | Greenberg et al. | Sep 2006 | A1 |
| 20060206110 | Knowlton et al. | Sep 2006 | A1 |
| 20060234899 | Nekmard et al. | Oct 2006 | A1 |
| 20060259102 | Slatkine | Nov 2006 | A1 |
| 20060265032 | Hennings et al. | Nov 2006 | A1 |
| 20060270745 | Hunt et al. | Nov 2006 | A1 |
| 20060293734 | Scott et al. | Dec 2006 | A1 |
| 20070010811 | Stern et al. | Jan 2007 | A1 |
| 20070010861 | Anderson et al. | Jan 2007 | A1 |
| 20070032561 | Lin et al. | Feb 2007 | A1 |
| 20070038156 | Rosenberg | Feb 2007 | A1 |
| 20070055156 | Desilets et al. | Mar 2007 | A1 |
| 20070055173 | DeLonzor et al. | Mar 2007 | A1 |
| 20070055179 | Deem et al. | Mar 2007 | A1 |
| 20070055180 | Deem et al. | Mar 2007 | A1 |
| 20070055181 | Deem et al. | Mar 2007 | A1 |
| 20070073367 | Jones et al. | Mar 2007 | A1 |
| 20070078502 | Weber et al. | Apr 2007 | A1 |
| 20070100398 | Sloan | May 2007 | A1 |
| 20070106342 | Schumann | May 2007 | A1 |
| 20070129714 | Elkins et al. | Jun 2007 | A1 |
| 20070135876 | Weber | Jun 2007 | A1 |
| 20070141265 | Thomson | Jun 2007 | A1 |
| 20070179482 | Anderson | Aug 2007 | A1 |
| 20070198071 | Ting et al. | Aug 2007 | A1 |
| 20070219540 | Masotti et al. | Sep 2007 | A1 |
| 20070239075 | Rosenberg et al. | Oct 2007 | A1 |
| 20070239150 | Zvuloni et al. | Oct 2007 | A1 |
| 20070249519 | Guha et al. | Oct 2007 | A1 |
| 20070255187 | Branch | Nov 2007 | A1 |
| 20070255274 | Stern et al. | Nov 2007 | A1 |
| 20070255362 | Levinson | Nov 2007 | A1 |
| 20070265585 | Joshi et al. | Nov 2007 | A1 |
| 20070265614 | Stern et al. | Nov 2007 | A1 |
| 20070270925 | Levinson | Nov 2007 | A1 |
| 20070282249 | Quisenberry et al. | Dec 2007 | A1 |
| 20070282318 | Spooner et al. | Dec 2007 | A1 |
| 20080014627 | Merchant et al. | Jan 2008 | A1 |
| 20080046047 | Jacobs | Feb 2008 | A1 |
| 20080058784 | Manstein et al. | Mar 2008 | A1 |
| 20080077201 | Levinson et al. | Mar 2008 | A1 |
| 20080077202 | Levinson | Mar 2008 | A1 |
| 20080077211 | Levinson et al. | Mar 2008 | A1 |
| 20080139901 | Altshuler et al. | Jun 2008 | A1 |
| 20080140061 | Toubia et al. | Jun 2008 | A1 |
| 20080140371 | Warner | Jun 2008 | A1 |
| 20080161892 | Mercuro et al. | Jul 2008 | A1 |
| 20080183164 | Elkins et al. | Jul 2008 | A1 |
| 20080188915 | Mills et al. | Aug 2008 | A1 |
| 20080248554 | Merchant et al. | Oct 2008 | A1 |
| 20080269851 | Deem et al. | Oct 2008 | A1 |
| 20080287839 | Rosen et al. | Nov 2008 | A1 |
| 20080312651 | Pope et al. | Dec 2008 | A1 |
| 20090012434 | Anderson | Jan 2009 | A1 |
| 20090018623 | Levinson et al. | Jan 2009 | A1 |
| 20090018624 | Levinson et al. | Jan 2009 | A1 |
| 20090018625 | Levinson et al. | Jan 2009 | A1 |
| 20090018626 | Levinson et al. | Jan 2009 | A1 |
| 20090018627 | Levinson et al. | Jan 2009 | A1 |
| 20090024023 | Welches et al. | Jan 2009 | A1 |
| 20090076488 | Welches et al. | Mar 2009 | A1 |
| 20090112134 | Avni | Apr 2009 | A1 |
| 20090118722 | Ebbers et al. | May 2009 | A1 |
| 20090149929 | Levinson et al. | Jun 2009 | A1 |
| 20090149930 | Schenck | Jun 2009 | A1 |
| 20090171253 | Davenport | Jul 2009 | A1 |
| 20090171334 | Elkins et al. | Jul 2009 | A1 |
| 20090221938 | Rosenberg et al. | Sep 2009 | A1 |
| 20090276018 | Brader | Nov 2009 | A1 |
| 20090281464 | Cioanta et al. | Nov 2009 | A1 |
| 20090299234 | Cho et al. | Dec 2009 | A1 |
| 20090306749 | Mulindwa | Dec 2009 | A1 |
| 20090312676 | Rousso et al. | Dec 2009 | A1 |
| 20090312693 | Thapliyal et al. | Dec 2009 | A1 |
| 20090326621 | El-Galley | Dec 2009 | A1 |
| 20100015190 | Hassler | Jan 2010 | A1 |
| 20100028969 | Mueller et al. | Feb 2010 | A1 |
| 20100030306 | Edelman et al. | Feb 2010 | A1 |
| 20100036295 | Altshuler et al. | Feb 2010 | A1 |
| 20100042087 | Goldboss et al. | Feb 2010 | A1 |
| 20100049178 | Deem et al. | Feb 2010 | A1 |
| 20100081971 | Allison | Apr 2010 | A1 |
| 20100087806 | Da Silva et al. | Apr 2010 | A1 |
| 20100152824 | Allison | Jun 2010 | A1 |
| 20100168726 | Brookman | Jul 2010 | A1 |
| 20100179531 | Nebrigic et al. | Jul 2010 | A1 |
| 20100198064 | Perl et al. | Aug 2010 | A1 |
| 20100217349 | Fahey et al. | Aug 2010 | A1 |
| 20100268220 | Johnson et al. | Oct 2010 | A1 |
| 20100280582 | Baker | Nov 2010 | A1 |
| 20110009860 | Chornenky et al. | Jan 2011 | A1 |
| 20110040235 | Castel | Feb 2011 | A1 |
| 20110040299 | Kim et al. | Feb 2011 | A1 |
| 20110046523 | Altshuler et al. | Feb 2011 | A1 |
| 20110060323 | Baust et al. | Mar 2011 | A1 |
| 20110066083 | Tosaya et al. | Mar 2011 | A1 |
| 20110066216 | Ting et al. | Mar 2011 | A1 |
| 20110077557 | Wing et al. | Mar 2011 | A1 |
| 20110077723 | Parish et al. | Mar 2011 | A1 |
| 20110112405 | Barthe et al. | May 2011 | A1 |
| 20110112520 | Kreindel | May 2011 | A1 |
| 20110144631 | Elkins et al. | Jun 2011 | A1 |
| 20110152849 | Baust et al. | Jun 2011 | A1 |
| 20110172651 | Altshuler et al. | Jul 2011 | A1 |
| 20110189129 | Qiu et al. | Aug 2011 | A1 |
| 20110196395 | Maschke | Aug 2011 | A1 |
| 20110196438 | Mnozil et al. | Aug 2011 | A1 |
| 20110202048 | Nebrigic et al. | Aug 2011 | A1 |
| 20110238050 | Allison et al. | Sep 2011 | A1 |
| 20110238051 | Levinson et al. | Sep 2011 | A1 |
| 20110257642 | Griggs, III | Oct 2011 | A1 |
| 20110300079 | Martens et al. | Dec 2011 | A1 |
| 20110301585 | Goulko | Dec 2011 | A1 |
| 20110313411 | Anderson et al. | Dec 2011 | A1 |
| 20110313412 | Kim et al. | Dec 2011 | A1 |
| 20120010609 | Deem et al. | Jan 2012 | A1 |
| 20120016239 | Barthe et al. | Jan 2012 | A1 |
| 20120022518 | Levinson | Jan 2012 | A1 |
| 20120022622 | Johnson et al. | Jan 2012 | A1 |
| 20120035475 | Barthe et al. | Feb 2012 | A1 |
| 20120035476 | Barthe et al. | Feb 2012 | A1 |
| 20120041525 | Karni | Feb 2012 | A1 |
| 20120046547 | Barthe et al. | Feb 2012 | A1 |
| 20120053458 | Barthe et al. | Mar 2012 | A1 |
| 20120065629 | Elkins et al. | Mar 2012 | A1 |
| 20120083862 | Altshuler et al. | Apr 2012 | A1 |
| 20120101549 | Schumann | Apr 2012 | A1 |
| 20120109041 | Munz | May 2012 | A1 |
| 20120158100 | Schomacker | Jun 2012 | A1 |
| 20120209363 | Williams, III et al. | Aug 2012 | A1 |
| 20120233736 | Tepper et al. | Sep 2012 | A1 |
| 20120239123 | Weber et al. | Sep 2012 | A1 |
| 20120253416 | Erez et al. | Oct 2012 | A1 |
| 20120259322 | Fourkas et al. | Oct 2012 | A1 |
| 20120277674 | Clark, III et al. | Nov 2012 | A1 |
| 20120310232 | Erez | Dec 2012 | A1 |
| 20130018236 | Altshuler et al. | Jan 2013 | A1 |
| 20130019374 | Schwartz | Jan 2013 | A1 |
| 20130035680 | Ben-Haim | Feb 2013 | A1 |
| 20130066309 | Levinson | Mar 2013 | A1 |
| 20130073017 | Liu et al. | Mar 2013 | A1 |
| 20130079684 | Rosen et al. | Mar 2013 | A1 |
| 20130116758 | Levinson et al. | May 2013 | A1 |
| 20130116759 | Levinson et al. | May 2013 | A1 |
| 20130150844 | Deem et al. | Jun 2013 | A1 |
| 20130158440 | Allison | Jun 2013 | A1 |
| 20130158636 | Ting et al. | Jun 2013 | A1 |
| 20130166003 | Johnson et al. | Jun 2013 | A1 |
| 20130190744 | Avram et al. | Jul 2013 | A1 |
| 20130238062 | Ron Edoute et al. | Sep 2013 | A1 |
| 20130245507 | Khorassani Zadeh | Sep 2013 | A1 |
| 20130253384 | Anderson et al. | Sep 2013 | A1 |
| 20130253493 | Anderson et al. | Sep 2013 | A1 |
| 20130253494 | Anderson et al. | Sep 2013 | A1 |
| 20130253495 | Anderson et al. | Sep 2013 | A1 |
| 20130253496 | Anderson et al. | Sep 2013 | A1 |
| 20130303904 | Barthe et al. | Nov 2013 | A1 |
| 20130303905 | Barthe et al. | Nov 2013 | A1 |
| 20130331914 | Lee et al. | Dec 2013 | A1 |
| 20140005759 | Fahey et al. | Jan 2014 | A1 |
| 20140005760 | Levinson et al. | Jan 2014 | A1 |
| 20140067025 | Levinson et al. | Mar 2014 | A1 |
| 20140142469 | Britva et al. | May 2014 | A1 |
| 20140200487 | Ramdas et al. | Jul 2014 | A1 |
| 20140200488 | Seo et al. | Jul 2014 | A1 |
| 20140222121 | Spence et al. | Aug 2014 | A1 |
| 20140277219 | Nanda | Sep 2014 | A1 |
| 20140277302 | Weber et al. | Sep 2014 | A1 |
| 20140277303 | Biser et al. | Sep 2014 | A1 |
| 20140303697 | Anderson et al. | Oct 2014 | A1 |
| 20150209174 | Abreu | Jul 2015 | A1 |
| 20150216719 | DeBenedictis et al. | Aug 2015 | A1 |
| 20150216720 | DeBenedictis et al. | Aug 2015 | A1 |
| 20150216816 | O'Neil et al. | Aug 2015 | A1 |
| 20150223975 | Anderson et al. | Aug 2015 | A1 |
| 20150328077 | Levinson | Nov 2015 | A1 |
| 20150335468 | Rose et al. | Nov 2015 | A1 |
| 20150342780 | Levinson et al. | Dec 2015 | A1 |
| 20160051308 | Pennybacker et al. | Feb 2016 | A1 |
| 20160051401 | Yee et al. | Feb 2016 | A1 |
| 20160135985 | Anderson | May 2016 | A1 |
| 20160324684 | Levinson et al. | Nov 2016 | A1 |
| 20170007309 | DeBenedictis et al. | Jan 2017 | A1 |
| 20170079833 | Frangineas, Jr. et al. | Mar 2017 | A1 |
| 20170105869 | Frangineas, Jr. et al. | Apr 2017 | A1 |
| 20170165105 | Anderson et al. | Jun 2017 | A1 |
| 20170196731 | DeBenedictis et al. | Jul 2017 | A1 |
| 20170239079 | Root et al. | Aug 2017 | A1 |
| 20170325992 | DeBenedictis et al. | Nov 2017 | A1 |
| 20170325993 | Jimenez Lozano et al. | Nov 2017 | A1 |
| 20170326042 | Zeng et al. | Nov 2017 | A1 |
| 20170326346 | Jimenez Lozano et al. | Nov 2017 | A1 |
| 20180161197 | Baker et al. | Jun 2018 | A1 |
| 20190125424 | DeBenedictis et al. | May 2019 | A1 |
| 20190142493 | Debenedictis et al. | May 2019 | A1 |
| Number | Date | Country |
|---|---|---|
| 2011253768 | Jun 2012 | AU |
| 2441489 | Mar 2005 | CA |
| 2585214 | Oct 2007 | CA |
| 333982 | Nov 1958 | CH |
| 86200604 | Oct 1987 | CN |
| 2514795 | Oct 2002 | CN |
| 2514811 | Oct 2002 | CN |
| 1511503 | Jul 2004 | CN |
| 1741777 | Mar 2006 | CN |
| 1817990 | Aug 2006 | CN |
| 2843367 | Dec 2006 | CN |
| 2850584 | Dec 2006 | CN |
| 2850585 | Dec 2006 | CN |
| 200970265 | Nov 2007 | CN |
| 101259329 | Sep 2008 | CN |
| 101309657 | Nov 2008 | CN |
| 532976 | Sep 1931 | DE |
| 2851602 | Jun 1980 | DE |
| 4213584 | Nov 1992 | DE |
| 4224595 | Jan 1994 | DE |
| 4238291 | May 1994 | DE |
| 4445627 | Jun 1996 | DE |
| 19800416 | Jul 1999 | DE |
| 263069 | Apr 1988 | EP |
| 0397043 | Nov 1990 | EP |
| 0406244 | Jan 1991 | EP |
| 560309 | Sep 1993 | EP |
| 0598824 | Jun 1994 | EP |
| 1030611 | Aug 2000 | EP |
| 1201266 | May 2002 | EP |
| 1568395 | Aug 2005 | EP |
| 2260801 | Dec 2010 | EP |
| 2289598 | Mar 2011 | EP |
| 2527005 | Nov 2012 | EP |
| 854937 | Apr 1940 | FR |
| 2744358 | Aug 1997 | FR |
| 2745935 | Sep 1997 | FR |
| 2767476 | Feb 1999 | FR |
| 2776920 | Oct 1999 | FR |
| 2789893 | Aug 2000 | FR |
| 2805989 | Sep 2001 | FR |
| 387960 | Feb 1933 | GB |
| 2120944 | Dec 1983 | GB |
| 2202447 | Sep 1988 | GB |
| 2248183 | Apr 1992 | GB |
| 2263872 | Aug 1993 | GB |
| 2286660 | Aug 1995 | GB |
| 2323659 | Sep 1998 | GB |
| 58187454 | Nov 1983 | JP |
| S6094113 | Jun 1985 | JP |
| 6282977 | Apr 1987 | JP |
| 63076895 | Apr 1988 | JP |
| 01223961 | Sep 1989 | JP |
| 03051964 | Mar 1991 | JP |
| 03259975 | Nov 1991 | JP |
| 04093597 | Mar 1992 | JP |
| 06261933 | Sep 1994 | JP |
| 07194666 | Aug 1995 | JP |
| 07268274 | Oct 1995 | JP |
| 09164163 | Jun 1997 | JP |
| 10216169 | Aug 1998 | JP |
| 10223961 | Aug 1998 | JP |
| 3065657 | Jul 2000 | JP |
| 2001046416 | Feb 2001 | JP |
| 2002125993 | May 2002 | JP |
| 2002224051 | Aug 2002 | JP |
| 2002282295 | Oct 2002 | JP |
| 2002290397 | Oct 2002 | JP |
| 2002543668 | Dec 2002 | JP |
| 2003190201 | Jul 2003 | JP |
| 2004013600 | Jan 2004 | JP |
| 2004073812 | Mar 2004 | JP |
| 2004159666 | Jun 2004 | JP |
| 2005039790 | Feb 2005 | JP |
| 2005065984 | Mar 2005 | JP |
| 2005110755 | Apr 2005 | JP |
| 2005509977 | Apr 2005 | JP |
| 3655820 | Jun 2005 | JP |
| 2005520608 | Jul 2005 | JP |
| 2005237908 | Sep 2005 | JP |
| 2005323716 | Nov 2005 | JP |
| 2006026001 | Feb 2006 | JP |
| 2006130055 | May 2006 | JP |
| 2006520949 | Sep 2006 | JP |
| 2007270459 | Oct 2007 | JP |
| 2008532591 | Aug 2008 | JP |
| 2009515232 | Apr 2009 | JP |
| 2009189757 | Aug 2009 | JP |
| 200173222 | Dec 1999 | KR |
| 20040094508 | Nov 2004 | KR |
| 20090000258 | Jan 2009 | KR |
| 1020130043299 | Apr 2013 | KR |
| 1020140038165 | Mar 2014 | KR |
| 2036667 | Jun 1995 | RU |
| 532976 | Nov 1978 | SU |
| 0476644 | Feb 2002 | TW |
| 8503216 | Aug 1985 | WO |
| 9114417 | Oct 1991 | WO |
| 9300807 | Jan 1993 | WO |
| 9404116 | Mar 1994 | WO |
| 9623447 | Aug 1996 | WO |
| 9626693 | Sep 1996 | WO |
| 9636293 | Nov 1996 | WO |
| 9637158 | Nov 1996 | WO |
| 9704832 | Feb 1997 | WO |
| 9705828 | Feb 1997 | WO |
| 9722262 | Jun 1997 | WO |
| 9724088 | Jul 1997 | WO |
| 9725798 | Jul 1997 | WO |
| 9748440 | Dec 1997 | WO |
| 9829134 | Jul 1998 | WO |
| 9831321 | Jul 1998 | WO |
| 9841156 | Sep 1998 | WO |
| 9841157 | Sep 1998 | WO |
| 9909928 | Mar 1999 | WO |
| 9916502 | Apr 1999 | WO |
| 9938469 | Aug 1999 | WO |
| 9949937 | Oct 1999 | WO |
| 0044346 | Aug 2000 | WO |
| 0044349 | Aug 2000 | WO |
| 0065770 | Nov 2000 | WO |
| 0067685 | Nov 2000 | WO |
| 0100269 | Jan 2001 | WO |
| 0113989 | Mar 2001 | WO |
| 0114012 | Mar 2001 | WO |
| 0134048 | May 2001 | WO |
| 0205736 | Jan 2002 | WO |
| 02102921 | Dec 2002 | WO |
| 03007859 | Jan 2003 | WO |
| 03078596 | Sep 2003 | WO |
| 03079916 | Oct 2003 | WO |
| 2004000098 | Dec 2003 | WO |
| 2004080279 | Sep 2004 | WO |
| 2004090939 | Oct 2004 | WO |
| 2005033957 | Apr 2005 | WO |
| 2005046540 | May 2005 | WO |
| 2005060354 | Jul 2005 | WO |
| 2005096979 | Oct 2005 | WO |
| 2005112815 | Dec 2005 | WO |
| 2006066226 | Jun 2006 | WO |
| 2006094348 | Sep 2006 | WO |
| 2006106836 | Oct 2006 | WO |
| 2006116603 | Nov 2006 | WO |
| 2006127467 | Nov 2006 | WO |
| 2007012083 | Jan 2007 | WO |
| 2007028975 | Mar 2007 | WO |
| 2007041642 | Apr 2007 | WO |
| 2007101039 | Sep 2007 | WO |
| 2007127924 | Nov 2007 | WO |
| 2007145421 | Dec 2007 | WO |
| 2007145422 | Dec 2007 | WO |
| 2008006018 | Jan 2008 | WO |
| 2008039556 | Apr 2008 | WO |
| 2008039557 | Apr 2008 | WO |
| 2008055243 | May 2008 | WO |
| 2008143678 | Nov 2008 | WO |
| 2009011708 | Jan 2009 | WO |
| 2009026471 | Feb 2009 | WO |
| 2010077841 | Jul 2010 | WO |
| 2010127315 | Nov 2010 | WO |
| 2012012296 | Jan 2012 | WO |
| 2012103242 | Aug 2012 | WO |
| 2013013059 | Jan 2013 | WO |
| 2013075006 | May 2013 | WO |
| 2013075016 | May 2013 | WO |
| 2013190337 | Dec 2013 | WO |
| 2014151872 | Sep 2014 | WO |
| 2014191263 | Dec 2014 | WO |
| 2015117001 | Aug 2015 | WO |
| 2015117005 | Aug 2015 | WO |
| 2015117026 | Aug 2015 | WO |
| 2015117032 | Aug 2015 | WO |
| 2015117036 | Aug 2015 | WO |
| 2016028796 | Feb 2016 | WO |
| 2016048721 | Mar 2016 | WO |
| Entry |
|---|
| Aguilar et al., “Modeling Cryogenic Spray Temperature and Evaporation Rate Based on Single-Droplet Analysis,” Eighth International Conference on Liquid Atomization and Spray Systems, Pasadena, CA, USA, Jul. 2000, 7 pages. |
| Al-Sakere, B. et al. “Tumor Ablation with Irreversible Electroporation,” PLoS One, Issue 11, Nov. 2007, 8 pages. |
| Alster, T. et al., “Cellulite Treatment Using a Novel Combination Radiofrequency, Infrared Light, and Mechanical Tissue Manipulation Device,” Journal of Cosmetic and Laser Therapy, vol. 7, 2005, pp. 81-85. |
| Ardevol, A. et al., “Cooling Rates of Tissue Samples During Freezing with Liquid Nitrogen,” Journal of Biochemical and Biophysical Methods, vol. 27, 1993, pp. 77-86. |
| Arena, C. B. et al., “High-Frequency Irreversible Electroporation (H-FIRE) for Non-Thermal Ablation Without Muscle Contraction,” BioMedical Engineering OnLine 2011, 10:102, Nov. 21, 2011, 21 pgs. |
| Becker, S. M. et al. “Local Temperature Rises Influence In Vivo Electroporation Pore Development: A Numerical Stratum Corneum Lipid Phase Transition Model,” Journal of Biomechanical Engineering, vol. 129, Oct. 2007, pp. 712-721. |
| Bohm, T. et al., “Saline-Enhanced Radiofrequency Ablation of Breast Tissue: an in Vitro Feasibility Study,” Investigative Radiology, vol. 35 (3), 2000, pp. 149-157. |
| Bondei, E. et al., “Disorders of Subcutaneous Tissue (Cold Panniculitis),” Dermatology in General Medicine, Fourth Edition, vol. 1, Chapter 108, 1993, Section 16, pp. 1333-1334. |
| Burge, S.M. et al., “Hair Follicle Destruction and Regeneration in Guinea Pig Skin after Cutaneous Freeze Injury,” Cryobiology, 27(2), 1990, pp. 153-163. |
| Coban, Y. K. et al., “Ischemia-Reperfusion Injury of Adipofascial Tissue: An Experimental Study Evaluating Early Histologic and Biochemical Alterations in Rats,” Mediators of Inflammation, 2005, 5, pp. 304-308. |
| Del Pino, M. E. et al. “Effect of Controlled Volumetric Tissue Heating with Radiofrequency on Cellulite and the Subcutaneous Tissue of the Buttocks and Thighs,” Journal of Drugs in Dermatology, vol. 5, Issue 8, Sep. 2006, pp. 714-722. |
| Donski, P. K. et al., “The Effects of Cooling no Experimental Free Flap Survival,” British Journal of Plastic Surgery, vol. 33, 1980, pp. 353-360. |
| Duck, F. A., Physical Properties of Tissue, Academic Press Ltd., chapters 4 & 5, 1990, pp. 73-165. |
| Duncan, W. C. et al., “Cold Panniculitis,” Archives of Dermatology, vol. 94, Issue 6, Dec. 1966, pp. 722-724. |
| Epstein, E. H. et al., “Popsicle Panniculitis,” The New England Journal of Medicine, 282(17), Apr. 23, 1970, pp. 966-967. |
| Fournier, L. et al. “Lattice Model for the Kinetics of Rupture of Fluid Bilayer Membranes,” Physical Review, vol. 67, 2003, pp. 051908-1-051908-11. |
| Gabriel, S. et al., “The Dielectric Properties of Biological Tissues: II. Measurements in the Frequency Range 10 Hz to 20 GHz,” Physics in Medicine and Biology, vol. 41, 1996, pp. 2251-2269. |
| Gage, A. “Current Progress in Cryosurgery,” Cryobiology 25, 1988, pp. 483-486. |
| Gatto, H. “Effects of Thermal Shocks on Interleukin-1 Levels and Heat Shock Protein 72 (HSP72) Expression in Normal Human Keratinocytes,” PubMed, Archives of Dermatological Research, vol. 284, Issue 7, 1992: pp. 414-417 [Abstract]. |
| Hale, H. B. et al., “Influence of Chronic Heat Exposure and Prolonged Food Deprivation on Excretion of Magnesium, Phosphorus, Calcium, Hydrogen Ion & Ketones,” Aerospace Medicine, vol. 39—No. 9, Sep. 1968, pp. 919-926. |
| Heller Page, E. et al., “Temperature-dependent skin disorders,” Journal of the American Academy of Dermatology, vol. 18, No. 5, Pt 1, May 1988, pp. 1003-1019. |
| Hemmingsson, A. et al. “Attenuation in Human Muscle and Fat Tissue in Vivo and in Vitro,” Acra Radiologica Diagnosis, vol. 23, No. 2, 1982, pp. 149-151. |
| Henry, F. et al., “Les Dermatoses Hivernales,” Rev Med Liege, 54:11, 1999, pp. 864-866. |
| Hernan, P. et al., “Study for the evaluation of the efficacy of Lipocryolysis (EEEL)”, Nov. 30, 2011. |
| Hernan, R. P., “A Study to Evaluate the Action of Lipocryolysis”, 33(3) CryoLellers, 2012, pp. 176-180. |
| Holland, DB. et al. “Cold shock induces the synthesis of stress proteins in human keratinocytes,” PubMed Journal of Investigative Dermatology; 101(2): Aug. 1993, pp. 196-199. |
| Holman, W. L. et al., “Variation in Cryolesion Penetration Due to Probe Size and Tissue Thermal Conductivity,” The Annals of Thoracic Surgery, vol. 53, 1992, pp. 123-126. |
| Hong, J.S. et al., “Patterns of Ice Formation in Normal and Malignant Breast Tissue,” Cryobiology 31, 1994, pp. 109-120. |
| Huang et al. “Comparative Proteomic Profiling of Murine Skin,” Journal of Investigative Dermatology, vol. 121(1), Jul. 2003, pp. 51-64. |
| Isambert, H. “Understanding the Electroporation of Cells and Artificial Bilayer Membranes,” Physical Review Letters, vol. 80, No. 15, 1998, pp. 3404-3707. |
| Jalian, H. R. et al., “Cryolipolysis: A Historical Perspective and Current Clinical Practice”, 32(1) Semin. Cutan. Med. Surg., 2013, pp. 31-34. |
| Kellum, R. E. et al., “Sclerema Neonatorum: Report of Case and Analysis of Subcutaneous and Epidermal-Dermal Lipids by Chromatographic Methods,” Archives of Dermatology, vol. 97, Apr. 1968, pp. 372-380. |
| Koska, J. et al., “Endocrine Regulation of Subcutaneous Fat Metabolism During Cold Exposure in Humans,” Annals of the New York Academy of Sciences, vol. 967, 2002, pp. 500-505. |
| Kumakura et al.; Office Action: Notification of Reason for Rejection; Japanese Patent Application No. 2010-213871; Dispatch No. 254910; Dispatched; Apr. 16, 2012; Drawn up on: Apr. 12, 2012. |
| Kundu, S. K. et al., “Breath Acetone Analyzer: Diagnostic Tool to Monitor Dietary Fat Loss,” Clinical Chemistry, vol. 39, Issue (1), 1993, pp. 87-92. |
| Kundu, S. K. et al., “Novel Solid-Phase Assay of Ketone Bodies in Urine,” Clinical Chemistry, vol. 37, Issue (9), 1991, pp. 1565-1569. |
| Kuroda, S. et al. “Thermal Distribution of Radio-Frequency Inductive Hyperthermia Using an Inductive Aperture-Type Applicator: Evaluation of the Effect of Tumor Size and Depth”, Medical and Biological Engineering and Computing, vol. 37, 1999, pp. 285-290. |
| Laugier, P. et al., “In Vivo Results with a New Device for Ultrasonic Monitoring of Pig Skin Cryosurgery: The Echographic Cryprobe,” The Society for Investigative Dermatology, Inc., vol. 111, No. 2, Aug. 1998, pp. 314-319. |
| Levchenko et al., “Effect of Dehydration on Lipid Metabolism” Ukrainskii Biokhimicheskii Zhurnal, vol. 50, Issue 1, 1978, pp. 95-97. |
| Lidagoster, MD et al., “Comparison of Autologous Fat Transfer in Fresh, Refrigerated, and Frozen Specimens: An Animal Model,” Annals of Plastic Surgery, vol. 44, No. 5, May 2000, pp. 512-515. |
| Liu, A. Y.-C. et al., “Transient Cold Shock Induces the Heat Shock Response upon Recovery at 37 C in Human Cells,” Journal of Biological Chemistry, , 269(20), May 20, 1994, pp. 14768-14775. |
| L'Vova, S.P. “Lipid Levels and Lipid Peroxidation in Frog Tissues During Hypothermia and Hibernation” Ukrainskii Biokhimicheskii Zhurnal, vol. 62, Issue 1, 1990, pp. 65-70. |
| Maize, J.C. “Panniculitis,” Cutaneous Pathology, Chapter 13, 1998, 327-344. |
| Malcolm, G. T. et al., “Fatty Acid Composition of Adipose Tissue in Humans: Differences between Subcutaneous Sites,” The American Journal of Clinical Nutrition, vol. 50, 1989, pp. 288-291. |
| Manstein, D. et al. “A Novel Cryotherapy Method of Non-invasive, Selective Lipolysis,” LasersSurg.Med 40:S20, 2008, p. 104. |
| Manstein, D. et al. “Selective Cryolysis: A Novel Method of Non-Invasive Fat Removal,” Lasers in Surgery and Medicine: The Official Journal of the ASLMS, vol. 40, No. 9, Nov. 2008, pp. 595-604. |
| Mayoral, “Case Reports: Skin Tightening with a Combined Unipolar and Bipolar Radiofrequency Device,” Journal of Drugs in Dermatology, 2007, pp. 212-215. |
| Mazur, P. “Cryobiology: The Freezing of Biological Systems,” Science, 68, 1970, pp. 939-949. |
| Merrill, T. “A Chill to the Heart: A System to Deliver Local Hypothermia Could One Day Improve the Lives of Heart-Attack Patients,” Mechanical Engineering Magazine, Oct. 2010, 10 pages. |
| Miklavcic, D. et al. “Electroporation-Based Technologies and Treatments,” The Journal of Membrane Biology (2010) 236:1-2, 2 pgs. |
| Moschella, S. L. et al., “Diseases of the Subcutaneous Tissue,” in Dermatology, Second Edition, vol. 2, 1985 Chapter 19, Section II (W.B. Saunders Company, 1980) pp. 1169-1181. |
| Murphy, J. V. et al., “Frostbite: Pathogenesis and Treatment” The Journal of Trauma: Injury, Infection, and Critical Care, vol. 48, No. 1, Jan. 2000, pp. 171-178. |
| Nagao, T. et al., “Dietary Diacylglycerol Suppresses Accumulation of Body Fat Compared to Triacylglycerol in Men a Double-Blind Controlled Trial,” The Journal of Nutrition, vol. 130, Issue (4), 2000, pp. 792-797. |
| Nagle, W. A. et al. “Cultured Chinese Hamster Cells Undergo Apoptosis After Exposure to Cold but Nonfreezing Temperatures,” Cryobiology 27, 1990, pp. 439-451. |
| Nagore, E. et al., “Lipoatrophia Semicircularis—a Traumatic Panniculitis: Report of Seven Cases and Review of the Literature,” Journal of the American Academy of Dermatology, vol. 39, Nov. 1998, pp. 879-881. |
| Nanda, G.S. et al., “Studies on electroporation of thermally and chemically treated human erythrocytes,” Bioelectrochemistry and Bioenergetics, 34, 1994, pp. 129-134, 6 pgs. |
| Narins, D.J. et al. “Non-Surgical Radiofrequency Facelift”, The Journal of Drugs in Dermatology, vol. 2, Issue 5, 2003, pp. 495-500. |
| Nielsen, B. “Thermoregulation in Rest and Exercise,” Acta Physiologica Scandinavica Supplementum, vol. 323 (Copenhagen 1969), pp. 7-74. |
| Nishikawa, H. et al. “Ultrastructural Changes and Lipid Peroxidation in Rat Adipomusculocutaneous Flap Isotransplants after Normothermic Storage and Reperfusion,” Transplantation, vol. 54, No. 5,1992, pp. 795-801. |
| Nurnberger, F. “So-Called Cellulite: An Invented Disease,” Journal of Dermatologic Surgery and Oncology, Mar. 1978, pp. 221-229. |
| Pease, G. R. et al., “An Integrated Probe for Magnetic Resonance Imaging Monitored Skin Cryosurgery,” Journal of Biomedical Engineering, vol. 117, Feb. 1995, pp. 59-63. |
| Pech, P. et al., “Attenuation Values, Volume Changes and Artifacts in Tissue Due to Freezing,” Acta Radiologica ,vol. 28, Issue 6, 1987, pp. 779-782. |
| Peterson, L. J. et al., “Bilateral Fat Necrosis of the Scrotum,” Journal of Urology, vol. 116, 1976, pp. 825-826. |
| Phinney, S. D. et al., “Human Subcutaneous Adipose Tissue Shows Site-Specific Differences in Fatty Acid Composition,” The American Journal of Clinical Nutrition, vol. 60, 1994, pp. 725-729. |
| Pierard, G.E. et al., “Cellulite: From Standing Fat Herniation to Hypodermal Stretch Marks,” The American Journal of Dermatology, vol. 22, Issue 1, 2000, pp. 34-37. |
| Pope, K. et al. “Selective Fibrous Septae Heating: An Additional Mechanism of Action for Capacitively Coupled Monopolar Radiofrequency” Thermage, Inc. Article, Feb. 2005, 6pgs. |
| Quinn, P. J. “A Lipid-Phase Separation Model of Low-Temperature Damage to Biological Membranes,” Cryobiology, 22, 1985, 128-146. |
| Rabi, T. et al., “Metabolic Adaptations in Brown Adipose Tissue of the Hamster in Extreme Ambient Temperatures,” American Journal of Physiology, vol. 231, Issue 1, Jul. 1976, pp. 153-160. |
| Renold, A.E. et al. “Adipose Tissue” in Handbook of Physiology, Chapter 15, (Washington, D.C., 1965) pp. 169-176. |
| Rossi, A. B. R. et al. “Cellulite: a Review,” European Academy of Dermatology and Venercology, 2000, pp. 251-262, 12 pgs. |
| Rubinsky, B. “Principles of Low Temperature Cell Preservation,” Heart Failure Reviews, vol. 8, 2003, pp. 277-284. |
| Rubinsky, B. et al., “Cryosurgery: Advances in the Application of low Temperatures to Medicine,” International Journal of Refrigeration, vol. 14, Jul. 1991, pp. 190-199. |
| Saleh, K.Y. et al., “Two-Dimensional Ultrasound Phased Array Design for Tissue Ablation for Treatment of Benign Prostatic Hyperplasia,” International Journal of Hyperthermia, vol. 20, No. 1, Feb. 2004, pp. 7-31. |
| Schoning, P. et al., “Experimental Frostbite: Freezing Times, Rewarming Times, and Lowest Temperatures of Pig Skin Exposed to Chilled Air,” Cryobiology 27, 1990, pp. 189-193. |
| Shephard, R. J. “Adaptation to Exercise in the Cold,” Sports Medicine, vol. 2, 1985, pp. 59-71. |
| Sigma-Aldrich “Poly (ethylene glycol) and Poly (ethylene oxide),” http://www.sigmaaldrich.com/materials-science/materialscience-; products.htmi?TablePage=2020411 0, accessed Oct. 19, 2012. |
| Smalls, L. K. et al. “Quantitative Model of Cellulite: Three Dimensional Skin Surface Topography, Biophysical Characterization, and Relationship to Human Perception,” International Journal of Cosmetic Science, vol. 27, Issue 5, Oct. 2005, 17 pgs. |
| Thermage, News Release, “Study Published in Facial Plastic Surgery Journal Finds Selective Heating of Fibrous Septae Key to Success and Safety of Thermage ThermaCool System,” Jun. 20, 2005, 2 pages. |
| Thermage, Inc. Tech Brochure, “ThermaCool Monopolar Capacitive Radiofrequency, the one choice for nonablative tissue tightening and contouring”, Nov. 30, 2005, 8 pgs. |
| Vallerand et al. “Cold Stress Increases Lipolysis, FFA Ra and TG/FFA Cycling in Humans,” Aviation, Space, and Environmental Medicine 70(1), 1999, pp. 42-50. |
| Wang, X. et al., “Cryopreservation of Cell/Hydrogel Constructs Based on a new Cell-Assembling Technique,” Sep. 5, 2009, 40 pages. |
| Wharton, D. A. et al., “Cold Acclimation and Cryoprotectants in a Freeze-Tolerant Antarctic Nematode, Panagrolaimus Davidi,”, Journal of Comparative Physiology, vol. 170, No. 4, Mar. 2000, 2 pages. |
| Winkler, C. et al., “Gene Transfer in Laboratory Fish: Model Organisms for the Analysis of Gene Function,” in Transgenic Animals, Generation and Use (The Netherlands 1997), pp. 387-395. |
| Young, H. E. et al. “Isolation of Embryonic Chick Myosatellite and Pluripotent Stem Cells” The Journal of Tissue Culture Methods, vol. 14, Issue 2, 1992, pp. 85-92. |
| Zelickson, B. et al., “Cryolipolysis for Noninvasive Fat Cell Destruction: Initial Results from a Pig Model”, 35 Dermatol. Sug., 2009, pp. 1-9. |
| Zouboulis, C. C. et al., “Current Developments and Uses of Cryosurgery in the Treatment of Keloids and Hypertrophic Scars,” Wound Repair and Regeneration, vol. 10, No. 2, 2002, pp. 98-102. |
| Number | Date | Country | |
|---|---|---|---|
| 20170239079 A1 | Aug 2017 | US |
| Number | Date | Country | |
|---|---|---|---|
| 62297054 | Feb 2016 | US |
