Claims
- 1. A recombinant polypeptide comprising a polypeptide sequence selected from the group consisting of an amino acid sequence at least 90 percent identical to SEQ ID No. 2, an amino acid sequence at least 90 percent identical to SEQ ID No. 4, a portion of an amino acid sequence at least 90 percent identical to SEQ ID No. 2, and a portion of an amino acid sequence at least 90 percent identical to SEQ ID No. 4, and which polypeptide or polypeptide portion binds to a mek-4 or sek receptor.
- 2. The recombinant polypeptide of claim 1, which binds to a mek-4 receptor.
- 3. The recombinant polypeptide of claim 1, which polypeptide sequence comprises a Cys4 motif at least 90 percent identical to a Cys4 motif having amino acids 69 through 159 of SEQ ID No. 2 or amino acids 61 through 150 of SEQ ID NO. 4.
- 4. The recombinant polypeptide of claim 1, which polypeptide sequence comprises a core sequence motif at least 90 percent identical to a core sequence motif having amino acids 35 through 166 of SEQ ID No. 2 or amino acids 33 through 157 of SEQ ID No. 4.
- 5. The recombinant polypeptide of claim 1, which polypeptide comprises a mature polypeptide sequence at least 90 percent identical with a mature polypeptide having the sequence of SEQ ID Nos. 2 or 4.
- 6. The recombinant polypeptide of claim 1, which polypeptide is post-translationally modified to include a phosphatidylinositol moiety, a carbohydrate, or both.
- 7. The recombinant polypeptide of claim 1, which protein is a fusion protein.
- 8. The recombinant polypeptide of claim 7, wherein said fusion protein further includes, in addition to said polypeptide sequence, a second polypeptide sequence which functions as a detectable label for detecting the presence of said fusion protein, or as a matrix-binding domain for immobilizing said fusion protein.
- 9. The recombinant polypeptide of claim 8, wherein said second polypeptide sequence has an enzymatic activity.
- 10. An isolated or recombinant polypeptide comprising a polypeptide sequence identical with an amino acid sequence set forth in the general formula designated by SEQ ID No. 5 and which polypeptide binds to a mek-4 or sek receptor.
- 11. The recombinant polypeptide of claim 1, which binds to a sek receptor.
- 12. The recombinant polypeptide of claim 1 consisting of SEQ ID NO. 2.
- 13. The recombinant polypeptide of claim 1 comprising SEQ ID NO. 4.
- 14. The recombinant polypeptide of claim 1 consisting of SEQ ID NO. 4.
REFERENCE TO RELATED APPLICATIONS
This application in a continuation-in-part of U.S. Ser. No. 08/308,814, filed Sep. 19, 1994, now abandoned, and entitled “EPH Receptor Ligands, and Uses Related Thereto”. The disclosure of U.S. Ser. No. 08/308,814 is incorporated by reference.
GOVERNMENT FUNDING
Work described herein was supported by National Institutes of Health Grants DK45580 and HD29417. The United States Government has certain rights in the invention.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
6268482 |
Cerretti |
Jul 2001 |
B1 |
Non-Patent Literature Citations (5)
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Mikayama T. Molecular cloning and funtional expression of a cDNA encoding glycosylation-inhibiting factor. Proc. Natl. Acad. Sci. USA vol. 90, pp. 10056-10060, 1993.* |
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Flanagan et al (1994) cell 79: 157-168.* |
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Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
08/308814 |
Sep 1994 |
US |
Child |
08/393462 |
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US |