Elder, B. et al. Genomics 16:374-379 (1993). |
Lollar, P. et al. J. Biol. Chem. 266(19):12481-12486 (1991). |
Arai, M., et al., "Molecular basis of factor VIII inhibition by human antibodies," 83 J. Clin. Invest. 1978-1984 (1989). |
Burke, R.L., et al., "The functional domains of coagulation factor VIII:C," 261 J. Biol. Chem. 12574-12578 (1986). |
Eaton, D., et al., "Proteolytic processing of human factor VIII, Correlation of specific cleavages by thrombin, factor Xa, and activated protein C with activation and inactivation of factor VIII coagulant activity," 25 Biochem. 505-512 (1986). |
Eaton, D.L., et al., "Construction and characterization of an active factor VIII variant lacking the central one-third of the molecule," 25 Biochem. 8343-8347 (1986). |
Eaton, D.L., et al., "Characterization of recombinant human factor VIII," 262 J. of Biol. Chem. 3285-3290 (1987). |
Fass, D.N., et al., "Monoclonal antibodies to porcine factor VIII coagulant and their use in the isolation of active coagulant protein," 59 Blood 594-600 (1982). |
Fay, P.J., et al., "The size of human factor VIII heterodimers and the effects produced by thrombin," 871 Biochimica et Biophysica Acta 268-278 (1986). |
Fay, P.J., "Subunit structure of thrombin-activated human factor VIII," 952 Biochimica et Biophysica Acta 181-190 (1987). |
Fay, P.J., "Reconstitution of human factor VIII from isolated subunits," 262 Arch. Biochem. Biophys. 525-531 (1988). |
Fay, P.J., et al., "Topography of the human factor VIII--von Willebrand factor complex," 265 J. Biol. Chem. 6197-6202 (1990). |
Fay, P.J., "von Willebrand factor mediates protection of factor VIII from activated protein C-catalyzed inactivation," 266 J. Biol. Chem. 2172-2177 (1991). |
Fay, P.J., et al., "Human factor VIII subunit structure," 266 J. Biol. Chem. 1-6 (1991). |
Fulcher, C.A., and T.S. Zimmerman, "Characterization of the human factor VIII procoagulant protein with a heterologous precipitating antibody," 79 Proc. Nat'l. Acad. Sci. U.S.A. 1648-1652 (1982). |
Fulcher, C.A., et al., "Human factor VIII procoagulant protein," 76 J. Clin. Invest. 117-124 (1985). |
Gitschier, J., et al., "Characterization of the human factor VIII gene," 312 Nature 326 -330 (1984). |
Hill-Eubanks, D.C., and P. Lollar, "von Willebrand factor is a cofactor for thrombin-catalyzed cleavage of the factor VIII light chain," 265 J. Biol. Chem. 17854-17858 (1990). |
Kaufman, R.J., et al., "Synthesis, processing, and secretion of recombinant human factor VIII expressed in mammalian cells," 263 J. Biol. Chem. 6352-6362 (1988). |
Kaufman, R.J., et al., "Effect of von Willebrand factor coexpression on the synthesis and secretion of factor VIII in Chinese hamster ovary cells," 9 Molec. Cell. Biol. 1233-1242 (1989). |
Koedam, J.A., et al., "The effect of von Willebrand factor on activation of factor VIII by factor Xa," 189 Eur. J. Biochem. 229-234 (1990). |
Kohn, D.B., and P.W. Kantoff, "Potential applications of gene therapy," 29 Transfusion 812-820 (1989). |
Leyte, A., et al., "Sulfation of Tyr.sup.1680 of human blood coagulation factor VIII is essential for the interaction of factor VIII with von Willebrand factor," 266 J. Biol. Chem. 740-746 (1991). |
Lollar, P., et al., "Activation of porcine factor VIII:C by thrombin and factor Xa," 24 Biochemistry 8056-8064 (1985). |
Lollar, P. (J.S.), et al., "Association of the factor VIII light chain with von Willebrand factor," 263 J. Biol. Chem. 10451 (1988). |
Lollar, P.(J.S.), et al., "Molecular characterization of commercial porcine factor VIII concentrate," 71 Blood 137-143 (1988). |
Lollar, P.(J.S.), and C.G. Parker, "Subunit structure of thrombin-activated porcine factor VIII," 28 Biochemistry 666-674 (1989). |
Lollar, P., and C.G. Parker, "pH-dependent denaturation of thrombin-activated porcine factor VIII," 265 J. Biol. Chem. 1688-1692 (1990). |
Lollar, P., "The association of factor VIII with von Willebrand factor," 66 Mayo Clin. Proc. 542-534 (1991). |
Lollar, P., and E.T. Parker, "Structural basis for the decreased procoagulent activity of human factor VIII compared to the porcine homolog," 266 J. Biol. Chem. 12481-12486 (1991). |
Mosesson, M.W., et al., "Structural model of porcine factor VIII and factor VIIIa molecules based on scanning transmission electron microscope (STEM) images and STEM mass analysis," 85 J. Clin. Invest. 1983-1990 (1990). |
Naylor, J.A., et al., "Detection of three novel mutations in two haemophilia A patients by rapid screening of whole essential region of factor VIII gene," 337 The Lancet 635-639 (1991). |
Pittman, D.D., and R.J. Kaufman, "Proteolytic requirements for thrombin activation of anti-hemophilic factor (factor VIII)," 85 Proc. Nat'l. Acad. Sci. U.S.A. 2429-2433 (1988). |
Roberts, H.R., and M.R. Jones, "Hemophilia and related conditions--Congenital deficiencies of prothrombin (factor IM, factor V, and factors VII to XII," Ch. 153, 1453-1474, 1460, in Hematology, Williams, W.J., et al., ed., 1990. |
Toole, J.J., et al., "Molecular cloning of a cDNA encoding human antihaemophilic factor," 312 Nature 342-347 (1984). |
Toole, J.J., et al., "A large region (.apprxeq.95 kDa) of human factor VIII is dispensable for in vitro procoagulent activity," 83 Proc. Nat'l. Acad. Sci. U.S.A. 5939-5942 (1986). |
Vehar, G.A., and E.W. Davie, "Preparation and properties of bovine factor VIII (antihemophilic factor)," 19 Biochem. 401-410 (1980). |
Vehar, G.A., et al., "Structure of human factor VIII," 312 Nature 337-342 (1984). |
Walker, F.J., et al., "Identification of the binding site for activated protein C on the light chain of factors V and VIII," 265 J. Biol. Chem. 1484-1489 (1990). |
Ware, J., et al., "Localization of a factor VIII-inhibiting antibody epitope to a region between residues 338 and 362 of factor VIII heavy chain," 85 Proc. Natl. Acad. Sci. USA 3165-3169 (1988). |
Wood, W.I., et al., "Expression of active human factor VIII from recombinant DNA clones," 312 Nature 330-337 (1984). |
Scandella, D., et al., "Localization of Epitopes for Human Factor VIII Inhibitor Antibodies by Immunoblotting and Antibody Neutralization," 111 (25) Chem. Abst. 570, Abst. 230240 (Dec. 18, 1989). |
Scandella, D., et al., "Localization of Epitopes for Human Factor VIII Inhibitor Antibodies by Immunoblotting and Antibody Neutralization," 82 (6) Blood 1767-1775 (1993). |
Scandella, D. et al., "A Recombinant Factor VIII A2 Domain Polypeptide Quantitatively Neutralizes Human Inhibitor Antibodies that Bind to A2," 121 (19) Chem. Abst. 782, Abst. 268801 (Dec. 20, 1993). |
Scandella, D. et al., "A Recombinant Factor VIII A2 Domain Polypeptide Quantitatively Neutralizes Human Inhibitor Antibodies that Bind to A2," 74 (5) Blood 1618-1626 (1989). |
Brinkhous, K.M., et al., "Purified Human Factor VIII Procoagulant Protein: Comparative Hemostatic Resonce After Infusions into Hemophilic and von Willebrand Disease Dogs", Proc. Natl. Acad. Sci. U.S.A., 82:8752-8755 (1985). |
Hoeben, R.C., "Expression of Functional Factor VIII in Primary Human Skin Fibroblasts After Retrovirus-mediated Gene Transfer", J. Biol. Chem., 265(13):7318-7323 (1990). |
Hoeben, R.C., et al., "Toward Gene Therapy for Hemophilia A: Long-Term Persistence for Factor VIII-Secreting Fibroblasts After Transplantation into Immunodeficient Mice", Human Gene Therapy, 4(2):179-186 (1993). |
Horton, R.M., et al., "Gene Splicing by Overlap Extension", Meth. Enzymol., 217:270 (1993). |
Levinson, B., et al., "Sequence of the Human Factor VIII-Associated Gene is Conserved in Mouse", Genomics, 13:862-865 (1992). |
Lollar, P., et al., "Inhibition of Human Factor VIIIa by Anti-A2 Subunit Antibodies", Blood, 82:Abstract No. 230 (1993). |
Lollar, P., et al., "Coagulant Properties of Hybrid Human-Porcine Factor VIII Molecules", J. Biol. Chem., 267:23652-23657 (1992). |
Lubin, I.M., et al., "Elimination of a Major Inhibitor Epitope in Factor VIII", J. Biol. Chem., 269(12):8639-8641 (1994). |
Lubin, L.M., et al., "Expression of a Recombinant Hybrid Human/Porcine Factor VIII Molecule with Elimination of Reactivity Toward an Inhibitory Anti-Human A2 Domain Antibody", Blood, 82:Abstract 229 (1993). |
Lusher, J.M., et al., "Recombinant Factor VIII for the Treatment of Previously Untreated Patients with hemophilia A", New. Engl. J. Med., 328(7):453-459 (1993). |
Pittman, D.D., et al., "A2 Domain of Human Recombinant-Derived Factor VIII is Required for Procoagulant Activity but not for Thrombin Cleavage", Blood, 79(2):389-397 (1992). |
Rebemtulla, A., "Improved Procoagulant Activity of Human Factor VIII Molecules Containing Portions of Porcine Sequence", Blood, 82:Abstract 1339 (1993). |
Sarkar, G., et al., "Access to a Messenger RNA Sequence or its Protein Product is not Limited by Tissue or Species Specificity", Science, 244:331-334 (1989). |
Shima, M., et al., "Factor VIII Neutralizing Monoclonal Antibody and a Human Inhibitor Alloantibody Recognizing Epitopes in the C2 Domain Inhibit Binding to von Willebrand Factor and to Phosphatidyl Serine", Thromb. Haemostas., 69:240-246 (1993). |