Hybrid polypeptides with enhanced pharmacokinetic properties

Abstract

The present invention relates to enhancer peptide sequences originally derived from various retroviral envelope (gp41) protein sequences that enhance the pharmacokinetic properties of any core polypeptide to which they are linked. The invention is based on the discovery that hybrid polypeptides comprising the enhancer peptide sequences linked to a core polypeptide possess enhanced pharmacokinetic properties such as increased half life. The invention further relates to methods for enhancing the pharmacokinetic properties of any core polypeptide through linkage of the enhancer peptide sequences to the core polypeptide. The core polypeptides to be used in the practice of the invention can include any pharmacologically useful peptide that can be used, for example, as a therapeutic or prophylactic reagent.

Description

1. INTRODUCTION

The present invention relates to enhancer peptide sequences originally derived from various retroviral envelope (gp41) protein sequences that enhance the pharmacokinetic properties of any core polypeptide to which they are linked. The invention is based on the discovery that hybrid polypeptides comprising the enhancer peptide sequences linked to a core polypeptide possess enhanced pharmacokinetic properties such as increased half life. The invention further relates to methods for enhancing the pharmacokinetic properties of any core polypeptide through linkage of the enhancer peptide sequences to the core polypeptide. The core polypeptides to be used in the practice of the invention can include any pharmacologically useful peptide that can be used, for example, as a therapeutic or prophylactic reagent. In a non-limiting embodiment, the invention is demonstrated by way of example wherein a hybrid polypeptide comprising, for example, an HIV core polypeptide linked to enhancer peptide sequences, is shown to be a potent, non-cytotoxic inhibitor of HIV-1, HIV-2 and SIV infection. Additionally, the enhancer peptide sequences of the invention have been linked to a respiratory syncytial virus (RSV) core polypeptide and a luteinizing hormone receptor (LH-RH) core polypeptide. In each instance, the hybrid polypeptide was found to possess enhanced pharmacokinetic properties, and the RSV hybrid polypeptide exhibited substantial anti-RSV activity.

2. BACKGROUND OF THE INVENTION

Polypeptide products have a wide range of uses as therapeutic and/or prophylactic reagents for prevention and treatment of disease. Many polypeptides are able to regulate biochemical or physiological processes to either prevent disease or provide relief from symptoms associated with disease. For example, polypeptides such as viral or bacterial polypeptides have been utilized successfully as vaccines for prevention of pathological diseases. Additionally, peptides have been successfully utilized as therapeutic agents for treatment of disease symptoms. Such peptides fall into diverse categories such, for example, as hormones, enzymes, immunomodulators, serum proteins and cytokines.

For polypeptides to manifest their proper biological and therapeutic effect on the target sites, the polypeptides must be present in appropriate concentrations at the sites of action. In addition, their structural integrity must generally be maintained. Therefore, the formulation of polypeptides as drugs for therapeutic use is directed by the chemical nature and the characteristics of the polypeptides, such as their size and complexity, their conformational requirements, and their often complicated stability, and solubility profiles. The pharmacokinetics of any particular therapeutic peptide is dependent on the bioavailability, distribution and clearance of said peptide.

Since many bioactive substances, such as peptides and proteins, are rapidly destroyed by the body, it is critical to develop effective systems for maintaining a steady concentration of peptide in blood circulation, to increase the efficacy of such peptides, and to minimize the incidence and severity of adverse side effects.

3. SUMMARY OF THE INVENTION

The present invention relates, first, to enhancer peptide sequences derived from various retroviral envelope (gp41) protein sequences i.e., HIV-1, HIV-2 and SIV, that enhance the pharmacokinetic properties of any core polypeptide to which they are linked. The invention is based on the surprising result that when the disclosed enhancer peptide sequences are linked to any core polypeptide, the resulting hybrid polypeptide possesses enhanced pharmacokinetic properties including, for example, increased half life and reduced clearance rate relative to the core polypeptide alone. The present invention further relates to such hybrid polypeptides and core polypeptides.

The core polypeptides to be used in the practice of the invention can comprise any peptides which may be introduced into a living system, for example, any peptides capable of functioning as therapeutic or prophylactic reagents useful for treatment or prevention of disease. Such peptides include, for example, growth factors, hormones, cytokines, angiogenic growth factors, extracellular matrix polypeptides or polypeptides that exhibit antifusogenic and/or antiviral activity, and peptides or polypeptides that function as immunogens including, for example, viral and bacterial polypeptides.

The invention further relates to methods for enhancing the pharmacokinetic properties of any core polypeptide through linkage of the core polypeptide to the enhancer peptide sequences to form hybrid polypeptides.

The invention is demonstrated by way of examples wherein hybrid polypeptides containing an HIV core polypeptide linked to enhancer peptide sequences are shown to exhibit greatly enhanced pharmacokinetic properties and act as a potent, non-cytotoxic inhibitors of HIV-1, HIV-2 and SIV infection. The invention is further demonstrated by examples wherein hybrid polypeptides containing an RSV core polypeptide or a luteinizing hormone polypeptide are shown to exhibit greatly enhanced pharmacokinetic properties. In addition, the RSV hybrid polypeptide exhibited substantial anti-RSV activity.

3.1. Definitions

Peptides are defined herein as organic compounds comprising two or more amino acids covalently joined by peptide bonds. Peptides may be referred to with respect to the number of constituent natural L-amino acids, i.e., a dipeptide contains two amino acid residues, a tripeptide contains three, etc. Peptides containing ten or fewer amino acids may be referred to as oligopeptides, while those with more than ten amino acid residues are polypeptides. Such peptides may also include non-natural amino acids and any of the modifications and additional amino and carboxyl groups as are described herein.

Peptide sequences defined herein are represented by one-letter symbols for amino acid residues as follows:

A (alanine)

R (arginine)

N (asparagine)

D (aspartic acid)

C (cysteine)

Q (glutamine)

E (glutamic acid)

G (glycine)

H (histidine)

I (isoleucine)

L (leucine)

K (lysine)

M (methionine)

F (phenylalanine)

P (proline)

S (serine)

T (threonine)

W (tryptophan)

Y (tyrosine)

V (valine)

X (any amino acid)

“Enhancer peptide sequences” are defined as peptides having the following consensus amino acid sequences: “WXXWXXXI”, “WXXWXXX”, “WXXWXX”, “WXXWX”, “WXXW”, “WXXXWXWX”, “XXXWXWX”, “XXWXWX”, “XWXWX”, “WXWX”, “WXXXWXW”, “WXXXWX”, “WXXXW”, “IXXXWXXW”, “XXXWXXW”, “XXWXXW”, “XWXXW”, “XWXWXXXW”, “XWXWXXX”, “XWXWXX”, “XWXWX”, “XWXW”, “WXWXXXW”, or “XWXXXW”, wherein X can be any amino acid, W represents tryptophan and I represents isoleucine. As discussed below, the enhancer peptide sequences of the invention also include peptide sequences that are otherwise the same as the consensus amino acid sequences but contain amino acid substitutions, insertions or deletions but which do not abolish the ability of the peptide to enhance the pharmacokinetic properties of a core peptide to which it is linked.

“Core polypeptide” as used herein, refers to any polypeptide which may be introduced into a living system and, thus, represents a bioactive molecule, for example any polypeptide that can function as a pharmacologically useful peptide for treatment or prevention of disease.

“Hybrid polypeptide” as used herein, refers to any polypeptide comprising a terminal enhancer peptide sequence and a core polypeptide.

4. BRIEF DESCRIPTION OF DRAWINGS

FIG. 1 . Hybrid polypeptides. Enhancer peptide sequences derived from putative N-terminal and C-terminal interactive regions are depicted linked to a core polypeptide. The critical enhancer peptide sequences are shaded. It is to be noted that the enhancer peptide sequences indicated may be used either as N- or C-terminal additions. Further, the enhancer peptide sequences can be added to a core polypeptide in forward or reverse orientation, individually or in any of the possible combinations, to enhance pharmacokinetic properties of the peptide.

FIG. 2 A. Enhancer peptide sequences derived from various envelope (gp41) protein sequences, representing the N-terminal interactive region observed in all currently published isolate sequences of HIV-1, HIV-2 and SIV (SEQ ID NOS:1129 and 1437-1473, respedtively. The final sequence “WXXWXXXI” represents a consensus sequence.

FIG. 2 B. Enhancer peptide sequence variants derived from various envelope (gp41) protein sequences, representing the C-terminal interactive region observed in all currently published isolate sequences of HIV-1, HIV-2 and SIV (SEQ ID NOS:1474-1512, respectively. The final sequence “WXXXWXWX” represents a consensus sequence.

FIG. 3 . Comparison of HIV-1 titres in tissues of HIV-1 9320 infected SCID-HuPBMC mice as measured by P24 Levels in HuPBMC co-culture assays. The figure shows a comparison of in vivo T20 and T1249 viral inhibition.

FIGS. 4A-4B . Plasma pharmacokinetic profile of T1249 vs T1387 core control in CD-rats following IV injection for up to 2 hrs ( FIG. 4A ) and 8 hrs (FIG. 4 B). The T1387 polypeptide is a core polypeptide and the T1249 polypeptide is the core polypeptide linked to enhancer peptide sequences.

FIG. 5 . Plasma pharmacokinetic profile of T1249 vs T20 control in CD-rats following IV administration. The T1249 polypeptide is a hybrid polypeptide of a core polypeptide (T1387) linked to enhancer peptide sequences. T20: n=4; T1249: n=3.

FIG. 6 . Comparison of T20/T1249 Anti-HIV-1/IIIb activity and cytotoxicity.

FIG. 7 . Direct Binding of T1249 to gp41construct M41Δ178 . 125 I-T1249 was HPLC purified to maximum specific activity. Saturation binding to M41Δ178 (a gp41ectodomain fusion protein lacking the T20 amino acid sequence) immobilized in microtitre plates at 0.5 mg/ml is shown.

FIG. 8 . Time Course of T1249 Association/Dissociation. Dissociation of bound radioligand was measured following the addition of unlabeled peptide to a final concentration of 10 μM in {fraction (1/10)} total assay volume.

FIG. 9 . Competition for T1249 Binding to M41Δ178. Unlabeled T1249 and T20 were titrated in the presence of a single concentration of either 125 I-T1249 or 125 I-T20. Ligand was added just after the unlabeled peptide to start the incubation.

FIGS. 10A-10B . Plasma pharmacokinetic profile of RSV hybrid polypeptides T1301 (10A) and T1302 (10B) vs T786 in CD rats.

FIG. 11 A. Plaque Reduction Assay. Hybrid polypeptide T1293 is capable of inhibiting RSV infection with an IC 50 2.6 μg/ml.

FIG. 11 B. Plaque Reduction Assay demonstrates the ability of RSV Hybrid Polypeptides T1301, T1302 and T1303 to inhibit RSV infection.

FIGS. 12A and 12B . Plasma pharmacokinetic profile of luteinizing hormone hybrid polypeptide T1324 vs T1323 in CD male rats. The T1323 polypeptide is a luteinizing hormone core polypeptide and the T1324 polypeptide is a hybrid polypeptide comprising a core polypeptide linked to enhancer peptide sequences.

FIG. 13 . Hybrid polypeptide sequences derived from various core polypeptides. Core polypeptide sequences are shown shaded (SEQ ID NOS: 1513, 15, 375, 397, 1514, 572, 386, 739, 897, 1515, 547, 746, 747, 1205, 1206, 1052, 1053, 1070, 1089, 1091, 1132, 1135, 1133, 1134, 1097, 1098, 1099, 1100, 1101, 1102, 1069, 1071, 1171, 1149, 1150, 1151, 1152, 1153, 1165, 1168, 1166, 1169, 1167, 1170, 1158, 1115, 1156, 1157, 1116, 1130, 1103, 1104, 1105, 1106, 1117, 63, 692, 970, 986, 969, 987, 988, 989, 1001, 1416, 1415, 1107, 1110, 1108, 1111, 1109, 1112, 1113, 1114, 1122, 1123, 1124, 1143, 1146, 1147, 1148, 1144, 1145, 1172, and 1173, in the order that sequences appear in the table).

5. DETAILED DESCRIPTION OF THE INVENTION

Described herein are peptide sequences, referred to as enhancer peptide sequences, derived from various retroviral envelope (gp41) protein sequences that are capable of enhancing the pharmacokinetic properties of core polypeptides to which they are linked. Such enhancer peptide sequences can be utilized in methods for enhancing the pharmacokinetic properties of any core polypeptide through linkage of the enhancer peptide sequences to the core polypeptide to form a hybrid polypeptide with enhanced pharmalokinetic properties relative to the core polypeptide alone.

The core polypeptides of the hybrid polypeptides of the invention comprise any peptide which may be introduced into a living system, for example, any peptide that can function as a therapeutic or prophylactic reagent useful for treatment or prevention of disease.

5.1. Hybrid Polypeptides

The hybrid polypeptides of the invention comprise at least one enhancer peptide sequence and a core polypeptide. The enhancer peptide sequences of the invention comprise peptide sequences originally derived from various retroviral envelope (gp 41) protein sequences including HIV-1, HIV-2 and SIV. While not wishing to be bound by any particular theory, the structure of the envelope protein is such that the putative α-helix region located in the C-terminal region of the protein is believed to associate with the leucine zipper region located in the N-terminal region of the protein. Alignment of the N-terminal and C-terminal enhancer peptide sequence gp41 regions observed in all currently published isolate sequences of HIV-1, HIV-2 and SIV identified consensus amino acid sequences.

In particular, the following consensus amino acid sequences were identified (the consensus sequences are listed below in forward and reverse orientations because said enhancer sequences can be utilized either in forward or reverse orientation): “WXXWXXXI”, “WXXWXXX”, “WXXWXX”, “WXXWX”, “WXXW”, “WXXXWXWX”, “XXXWXWX”, “XXWXWX”, “XWXWX”, “WXWX”, “WXXXWXW”, “WXXXWX”, “WXXXW”, “IXXXWXXW”, “XXWXXW”, “XXWXXW”, “XWXXW”, “XWXWXXW”, “XWXWXXX”, “XWXWXX”, “XWXWX”, “XXWXXW”, “WXWXXW”, or “XWXXXW”, wherein X can be any amino acid, W represents tryptophan and I represents isoleucine. Forward orientations of consensus amino acid sequences are shown in FIGS. 1 and 2 .

In a preferred embodiment of the invention, enhancer peptide sequences which may be used to enhance the pharmacokinetic properties of the resultant hybrid polypeptides comprise the enhancer sequences depicted in FIG. 2 . In another preferred embodiment, enhancer peptide sequences of the invention comprise the enhancer peptide sequences depicted in FIG. 2 exhibiting conserved amino acid substitutions at one or more residues wherein said substitutions do not abolish the ability of the enhancer peptide sequence to enhance the pharmacokinetic properties of a hybrid polypeptide relative to its corresponding core polypeptide. Among the most preferred enhancer peptide sequences are ones comprising the following amino sequence: “WQEWEQKI (SEQ ID NO:1129)” and “WASLWEWF (SEQ NO:1433)”.

The present invention further provides enhancer peptide sequences comprising amino acid sequences of FIGS. 1 and 2 that are otherwise the same, but, that said enhancer peptide sequences comprise one or more amino acid substitutions, additions (generally no greater than about 15 amino acid residues in length) or deletions (for example, amino- or terminal-truncations) which nevertheless are able to increase the pharmacokinetic properties of core polypeptides to which they are linked relative to core polypeptides without such enhancer sequences.

In particular, it is understood that certain amino acid residues comprising the consensus amino acid sequence of the enhancer peptide sequences can be replaced with other amino acid residues without significantly deleteriously affecting, and in some instances even enhancing, the activity of the peptides. Thus, also contemplated by the present invention are altered forms of the enhancer peptide sequence wherein at least one defined amino acid residue in the structure is substituted with another amino acid residue. Such amino acid substitutions may be conservative i.e., the replacing amino acid residue has physical and chemical properties (e.g., similar charge, size and/or hydrophobicity characteristics) that are similar to the amino acid residue being replaced, or non-conservative amino acid substitutions.

A critical feature affecting the activity of the peptides of the invention is their ability to increase the pharmacokinetic properties of core polypeptides to which they are linked relative to the core polypeptides above, thus it will be recognized that in preferred embodiments of the invention, the amino acid substitutions do not affect the ability of the enhancer peptides to increase the pharmacokinetic properties of the peptide. In general, such changes involve the “X” amino acid residues of the enhancer peptide consensus sequences.

In addition, the amino acid substitutions need not be, and in certain embodiments preferably are not, restricted to the genetically encoded amino acids. Indeed, the peptides may contain genetically non-encoded amino acids. Thus, in addition to the naturally occurring genetically encoded amino acids, amino acid residues in the peptides may be substituted with naturally occurring non-encoded amino acids and synthetic amino acids.

Certain commonly encountered amino acids which provide useful substitutions include, but are not limited to, β-alanine (β-Ala) and other omega-amino acids such as 3-aminopropionic acid, 2,3-diaminopropionic acid (Dpr), 4-aminobutyric acid and so forth; α-aminoisobutyric acid (Aib); ε-aminohexanoic acid (Aha); δ-aminovaleric acid (Ava); N-methylglycine or sarcosine (MeGly); ornithine (Orn); citrulline (Cit); t-butylalanine (t-BuA); t-butylglycine (t-BuG); N-methylisoleucine (MeIle); phenylglycine (Phg); cyclohexylalanine (Cha); norleucine (Nle); naphthylalanine (Nal); 4-chlorophenylalanine (Phe(4-Cl)); 2-fluorophenylalanine (Phe(2-F)); 3-fluorophenylalanine (Phe(3-F)); 4-fluorophenylalanine (Phe(4-F)); penicillamine (Pen); 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (Tic); β-2-thienylalanine (Thi); methionine sulfoxide (MSO); homoarginine (hArg); N-acetyl lysine (AcLys); 2,4-diaminobutyric acid (Dbu); 2,4-diaminobutyric acid (Dab); p-aminophenylalanine (Phe(pNH 2 )); N-methyl valine (MeVal); homocysteine (hCys), homophenylalanine (hphe) and homoserine (hSer); hydroxyproline (Hyp), homoproline (hPro), N-methylated amino acids and peptoids (N-substituted glycines).

While in most instances, the amino acids of the peptide will be substituted with L-enantiomeric amino acids, the substitutions are not limited to L-enantiomeric amino acids. Thus, also included in the definition of “mutated” or “altered” forms are those situations where an L-amino acid is replaced with an identical D-amino acid (e.g., L-Arg→D-Arg) or with a D-amino acid of the same category or subcategory (e.g., L-Arg→D-Lys), and vice versa.

It is to be understood that the present invention also contemplates peptide analogues wherein one or more amide linkage is optionally replaced with a linkage other than amide, preferably a substituted amide or an isostere of amide. Thus, while the amino acid residues within peptides are generally described in terms of amino acids, and preferred embodiments of the invention are exemplified by way of peptides, one having skill in the art will recognize that in embodiments having non-amide linkages, the term “amino acid” or “residue” as used herein refers to other bifunctional moieties bearing groups similar in structure to the side chains of the amino acids. In addition the amino acid residues may be blocked or unblocked.

Additionally, one or more amide linkages can be replaced with peptidomimetic or amide mimetic moieties which do not significantly interfere with the structure or activity of the peptides. Suitable amide mimetic moieties are described, for example, in Olson et al., 1993, J. Med. Chem. 36:3049.

Enhancer peptide sequences can be used to enhance the pharmacokinetic properties of the core polypeptide as either N-terminal or C-terminal additions. While it is preferable for the enhancer peptide sequences to be utilized in a pairwise fashion, that is, preferably hybrid polypeptides comprise an enhancer peptide sequence at both the amino- and carboxy-termini, hybrid polypeptides can also comprise a single enhancer peptide, said peptide present at either the amino- or carboxy-terminus of the hybrid polypeptide. Further, the enhancer peptides can be used in either forward or reverse orientation, or in any possible combination, linked to a core polypeptide. It is noted that any of the enhancer peptides can be introduced at either the N-terminus on the C-terminus of the core polypeptide.

It is understood that the core polypeptide may be linked to the enhancer peptides via a peptide amide linkage, although linkages other than amide linkages can be utilized to join the enhancer peptide sequences to the core polypeptides. Such linkages include for example any carbon-carbon, ester or chemical bond that functions to link the enhancer peptide sequences of the invention to a core peptide.

The amino- and/or carboxy-termini of the resulting hybrid polypeptide can comprise an amino group (—NH 2 ) or a carboxy (—COOH) group, respectively. Alternatively, the hybrid polypeptide amino-terminus may, for example, represent a hydrophobic group, including but not limited to carbobenzyl, dansyl, T-butoxycarbonyl, decanoyl, napthoyl or other carbohydrate group; an acetyl group; 9-fluorenylmethoxy-carbonyl (FMOC) group; or a modified, non-naturally occurring amino acid residue. Alternatively, the hybrid polypeptide carboxy-terminus can, for example, represent an amido group; a T-buxoxycarbonyl group; or a modified non-naturally occurring amino acid residue. As a non-limiting example, the amino- and/or carboxy-termini of the resulting hybrid polypeptide can comprise any of the amino- and/or carboxy-terminal modifications depicted in the peptides shown in FIG. 13 or Table 1, below.

The core polypeptides to be used in the practice of the invention comprise any polypeptide which may be introduced into a living system, for example, any polypeptide that can function as a pharmacologically useful polypeptide. Such core polypeptides may be useful for the treatment or prevention of disease. Examples of possible core polypeptides include growth factors, cytokines, therapeutic polypeptides, hormones and peptide fragments of hormones, inhibitors of cytokines, peptide growth and differentiation factors, interleukins, chemokines, interferons, colony stimulating factors, angiogenic factors and extracellular matrix proteins such as collagen, laminin and fibronectin to name a few. In addition, possible core polypeptides may include viral or bacterial polypeptides that may function either directly or as immunogens, and thus may be useful in the treatment or prevention of pathological disease.

Representative examples of hybrid polypeptides which comprise core polypeptides derived from viral protein sequences are shown in FIG. 13 . Core polypeptide sequences are shaded. Core polypeptides also include, but are not limited to, the polypeptides disclosed in U.S. Pat. No. 5,464,933, U.S. Pat. No. 5,656,480 and WO 96/19495, each of which is incorporated herein by reference in its entirety.

Core polypeptide sequences can further include, but are not limited to the core polypeptide sequences depicted in FIG. 13 and Table 1, below.

It is to be understood that such core polypeptide sequences, per se, can exhibit antiviral and/or anti-fusogenic activity and are considered part of the present invention. Among the core polypeptide sequences are, for example, ones which have been derived from individual viral protein sequences. Also among the core polypeptide sequences are, for example, ones whose amino acid sequences are derived from greater than one viral protein sequence (e.g., an HIV-1, HIV-2 and SIV-derived core polypeptide).

The amino- and carboxy-termini of such core polypeptides (either Per se or as part of a hybrid polypeptide) can be as discussed above for hybrid polypeptides. It is noted that while a number of the core polypeptides listed in Table 1, above, are depicted with modified, e.g., blocked amino and/or carboxy termini, that any core polypeptide comprising an unmodified primary amino acid sequence as depicted in Table 1 are to also be considered part of the present invention.

In addition, such core polypeptides can exhibit amino acid substitutions, deletions and/or insertions as discussed, above, for enhancer polypeptide sequences as long as the particular core polypeptide's antiviral and/or antifusogenic activity (either per se or as part of a hybrid polypeptide) is not abolished. With respect to amino acid deletions, it is preferable that the resulting core polypeptide is at least about 4-6 amino acid residues in length. With respect to amino acid insertions, preferable insertions are no greater than about 50 amino acid residues, and, more preferably no more than about 15 amino acid residues. It is also preferable that core polypeptide insertions be amino- and/or carboxy-terminal insertions.

Among such amino and/or carboxy-terminal insertions are ones which comprise amino acid sequences amino and/or carboxy to the endogenous protein sequence from which the core polypeptide is derived. For example, if the core polypeptide is derived from gp41protein, such an insertion would comprise an amino and/or carboxy-terminal insertion comprising a gp41 amino acid sequence adjacent to the gp41 core polypeptide sequence.

The invention further relates to the association of the enhancer core polypeptide sequences to types of molecules other than peptides. For example, the enhancer peptide sequences may be linked to nucleic acid molecules (e.g., DNA or RNA) or any type of small organic molecule for the purpose of enhancing the pharmacokinetic properties of said molecules.

5.2. Synthesis of Peptides

The enhancer, core and hybrid polypeptides of the invention may be synthesized or prepared by techniques well known in the art. See, for example, Creighton, 1983, Proteins: Structures and Molecular Principles, W. H. Freeman and Co., N.Y., which is incorporated herein by reference in its entirety. Hybrid polypeptides may be prepared using conventional step-wise solution or solid phase synthesis, fragment condensation, F-MOC or T-BOC chemistry. (see, e.g., Chemical Approaches to the Synthesis of Peptides and Proteins, Williams et al., Eds., 1997, CRC Press, Boca Raton Fla., and references cited therein; Solid Phase Peptide Synthesis: A Practical Approach, Atherton & Sheppard, Eds., 1989, IRL Press, Oxford, England, and references cited therein). Likewise the amino- and/or carboxy-terminal modifications.

The enhancer, core and hybrid polypeptides of the invention can be purified by art-known techniques such as normal and reverse phase high performance liquid chromatography, ion exchange chromatography, gel electrophoresis, affinity chromatography, size exclusion, precipitation and the like. The actual conditions used to purify a particular polypeptide will depend, in part, on synthesis strategy and on factors such as net charge, hydrophobicity, hydrophilicity, solubility, stability etc., and will be apparent to those having skill in the art.

Hybrid, enhancer and core polypeptides may also be made using recombinant DNA techniques. Here, the nucleotide sequences encoding the polypeptides of the invention may be synthesized, and/or cloned, and expressed according to techniques well known to those of ordinary skill in the art. See, for example, Sambrook, et al., 1989, Molecular Cloning, A Laboratory Manual, Vols. 1-3, Cold Spring Harbor Press, N.Y.

One may obtain the DNA segment encoding the polypeptide of interest using a variety of molecular biological techniques, generally known to those skilled in the art. For example, polymerase chain reaction (PCR) may be used to generate the DNA fragment encoding the protein of interest. Alternatively, the DNA fragment may be obtained from a commercial source.

The DNA encoding the polypeptides of interest may be recombinantly engineered into a variety of host vector systems that also provide for replication of the DNA in large scale. These vectors can be designed to contain the necessary elements for directing the transcription and/or translation of the DNA sequence encoding the hybrid polypeptide.

Vectors that may be used include, but are not limited to, those derived from recombinant bacteriophage DNA, plasmid DNA or cosmid DNA. For example, plasmid vectors such as pcDNA3, pBR322, pUC 19/18, pUC 118, 119 and the M13 mp series of vectors may be used. Bacteriophage vectors may include λgt10, λgt11, λgt18-23, λZAP/R and the EMBL series of bacteriophage vectors. Cosmid vectors that may be utilized include, but are not limited to, pJB8, pCV 103, pCV 107, pCV 108, pTM, pMCS, pNNL, pHSG274, COS202, COS203, pWE15, pWE16 and the charomid 9 series of vectors.

Alternatively, recombinant virus vectors including, but not limited to, those derived from viruses such as herpes virus, retroviruses, vaccinia viruses, adenoviruses, adeno-associated viruses or bovine papilloma viruses plant viruses, such as tobacco mosaic virus and baculovirus may be engineered.

In order to express a biologically active polypeptide, the nucleotide sequence coding for the protein may be inserted into an appropriate expression vector, i.e., a vector which contains the necessary elements for the transcription and translation of the inserted coding sequences. Methods which are well known to those skilled in the art can be used to construct expression vectors having the hybrid polypeptide coding sequence operatively associated with appropriate transcriptional/translational control signals. These methods include in vitro recombinant DNA techniques and synthetic techniques. See, for example, the techniques described in Sambrook, et al., 1992 , Molecular Cloning, A Laboratory Manual , Cold Spring Harbor Laboratory, N.Y. and Ausubel et al., 1989 , Current Protocols in Molecular Biology , Greene Publishing Associates & Wiley Interscience, N.Y., each of which are incorporated herein by reference in its entirety.

The nucleic acid molecule encoding the hybrid, enhancer and core polypeptides of interest may be operatively associated with a variety of different promoter/enhancer elements. The promoter/enhancer elements may be selected to optimize for the expression of therapeutic amounts of protein. The expression elements of these vectors may vary in their strength and specificities. Depending on the host/vector system utilized, any one of a number of suitable transcription and translation elements may be used. The promoter may be in the form of the promoter which is naturally associated with the gene of interest. Alternatively, the DNA may be positioned under the control of a recombinant or heterologous promoter, i.e., a promoter that is not normally associated with that gene. For example, tissue specific promoter/enhancer elements may be used to regulate the expression of the transferred DNA in specific cell types.

Examples of transcriptional control regions that exhibit tissue specificity which have been described and could be used include, but are not limited to, elastase I gene control region which is active in pancreatic acinar cells (Swift et al., 1984 , Cell 38:639-646; Ornitz et al., 1986 , Cold Spring Harbor Symp. Ouant. Biol . 50:399-409; MacDonald, 1987 , Hepatolocgy 7:42S-51S); insulin gene control region which is active in pancreatic beta cells (Hanahan, 1985 , Nature 315:115-122); immunoglobulin gene control region which is active in lymphoid cells (Grosschedl et al., 1984 , Cell 38:647-658; Adams et al., 1985 , Nature 318:533-538; Alexander et al., 1987 , Mol. Cell. Biol . 7:1436-1444): albumin gene control region which is active in liver (Pinkert et al., 1987 , Genes and Devel . 1:268-276) alpha-fetoprotein gene control region which is active in liver (Krumlauf et al., 1985 , Mol. Cell. Biol . 5:1639-1648; Hammer et al., 1987 , Science 235:53-58); alpha-1-antitrypsin gene control region which is active in liver (Kelsey et al., 1987 , Genes and Devel . 1:161-171); beta-globin gene control region which is active in myeloid cells (Magram et al., 1985 , Nature 315:338-340; Kollias et al., 1986 , Cell 46:89-94); myelin basic protein gene control region which is active in oligodendrocyte cells in the brain (Readhead et al., 1987 , Cell 48:703-712); myosin light chain-2 gene control region which is active in skeletal muscle (Shani, 1985 , Nature 314:283-286); and gonadotropic releasing hormone gene control region which is active in the hypothalamus (Mason et al., 1986 , Science 234:1372-1378). Promoters isolated from the genome of viruses that grow in mammalian cells, (e.g., vaccinia virus 7.5K, SV40, HSV, adenoviruses MLP, MMTV, LTR and CMV promoters) may be used, as well as promoters produced by recombinant DNA or synthetic techniques.

In some instances, the promoter elements may be constitutive or inducible promoters and can be used under the appropriate conditions to direct high level or regulated expression of the nucleotide sequence of interest. Expression of genes under the control of constitutive promoters does not require the presence of a specific substrate to induce gene expression and will occur under all conditions of cell growth. In contrast, expression of genes controlled by inducible promoters is responsive to the presence or absence of an inducing agent.

Specific initiation signals are also required for sufficient translation of inserted protein coding sequences. These signals include the ATG initiation codon and adjacent sequences. In cases where the entire coding sequence, including the initiation codon and adjacent sequences are inserted into the appropriate expression vectors, no additional translational control signals may be needed. However, in cases where only a portion of the coding sequence is inserted, exogenous translational control signals, including the ATG initiation codon must be provided. Furthermore, the initiation codon must be in phase with the reading frame of the protein coding sequences to ensure translation of the entire insert. These exogenous translational control signals and initiation codons can be of a variety of origins, both natural and synthetic. The efficiency of expression may be enhanced by the inclusion of transcription attenuation sequences, enhancer elements, etc.

5.3. Pharmaceutical Formulations, Dosages and Modes of Administration

The peptides of the invention may be administered using techniques well known to those in the art. Preferably, agents are formulated and administered systemically. Techniques for formulation and administration may be found in “Remington's Pharmaceutical Sciences”, 18th ed., 1990, Mack Publishing Co., Easton, Pa. Suitable routes may include oral, rectal, vaginal, lung, transdermal, transmucosal, or intestinal administration; parenteral delivery, including intramuscular, subcutaneous, intramedullary injections, as well as, intrathecal, direct intraventricular, intravenous, intraperitoneal, intranasal, or intraocular injections, just to name a few. For intravenous injection, the agents of the invention may be formulated in aqueous solutions, preferably in physiologically compatible buffers such as Hanks' solution, Ringer's solution, or physiological saline buffer to name a few. In addition, infusion pumps may be used to deliver the peptides of the invention. For such transmucosal administration, penetrants appropriate to the barrier to be permeated are used in the formulation. Such penetrants are generally known in the art.

In instances wherein intracellular administration of the peptides of the invention or other inhibitory agents is preferred, techniques well known to those of ordinary skill in the art may be utilized. For example, such agents may be encapsulated into liposomes, or microspheres then administered as described above. Liposomes are spherical lipid bilayers with aqueous interiors. All molecules present in an aqueous solution at the time of liposome formation are incorporated into the aqueous interior. The liposomal contents are both protected from the external microenvironment and, because liposomes fuse with cell membranes, are effectively delivered into the cell cytoplasm. Additionally, due to their hydrophobicity, when small molecules are to be administered, direct intracellular administration may be achieved.

Nucleotide sequences encoding the peptides of the invention which are to be intracellularly administered may be expressed in cells of interest, using techniques well known to those of skill in the art. For example, expression vectors derived from viruses such as retroviruses, vaccinia viruses, adeno-associated viruses, herpes viruses, or bovine papilloma viruses, may be used for delivery and expression of such nucleotide sequences into the targeted cell population. Methods for the construction of such vectors and expression constructs are well known. See, for example, Sambrook et al., 1989, Molecular Cloning, A Laboratory Manual, Cold Spring Harbor Press, Cold Spring Harbor N.Y., and Ausubel et al., 1989, Current Protocols in Molecular Biology, Greene Publishing Associates and Wiley Interscience, N.Y.

Effective dosages of the peptides of the invention to be administered may be determined through procedures well known to those in the art which address such parameters as biological half-life, bioavailability, and toxicity. In one embodiment, an effective hybrid polypeptide dosage range is from 0.1-100 μg/kg body weight. A therapeutically effective dose refers to that amount of the compound sufficient to result in amelioration of symptoms or a prolongation of survival in a patient. Toxicity and therapeutic efficacy of such compounds can be determined by standard pharmaceutical procedures in cell cultures or experimental animals, e.g., for determining the LD 50 (the dose lethal to 50% of the population) and the ED 50 ( (the dose therapeutically effective in 50% of the population). The dose ratio between toxic and therapeutic effects is the therapeutic index and it can be expressed as the ratio LD 50 /ED 50 . Compounds which exhibit large therapeutic indices are preferred. The data obtained from these cell culture assays and animal studies can be used in formulating a range of dosage for use in humans. The dosage of such compounds lies preferably within a range of circulating concentrations that include the ED 50 with little or no toxicity. The dosage may vary within this range depending upon the dosage form employed and the route of administration utilized. For any compound used in the method of the invention, the therapeutically effective dose can be estimated initially from cell culture assays. A dose may be formulated in animal models to achieve a circulating plasma concentration range that includes the IC 50 (e.g., the concentration of the test compound which achieves a half-maximal inhibition of the fusogenic event, such as a half-maximal inhibition of viral infection relative to the amount of the event in the absence of the test compound) as determined in cell culture. Such information can be used to more accurately determine useful doses in humans. Levels in plasma may be measured, for example, by high performance liquid chromatography (HPLC) or any biological or immunological assay capable of measuring peptide levels.

The hybrid polypeptides of the invention can also be administered in combination with at least one other therapeutic agent. Administration can be concomitantly or sequentially, including cycling therapy (that is, administration of a first compound for a period of time, followed by administration of a second antiviral compound for a period of time and repeating this sequential administration in order to reduce the development of resistance to one of the therapies).

In the case of viral infections, an effective amount of a hybrid polypeptide or a pharmaceutically acceptable derivative thereof can be administered in combination with at least one other antiviral agent. Such antiviral agents can include, but are not limited to DP-107, DP-178, cytokines, e.g., rIFN α, rIFN β, rIFN γ; inhibitors of reverse transcriptase, e.g., AZT, 3TC, D4T, ddI, and other dideoxynucleosides or dideoxyfluoronucleosides; inhibitors of viral mRNA capping, such as ribavirin; inhibitors of HIV protease, such as ABT-538 and MK-639; amphotericin B as a lipid-binding molecule with anti-HIV activity; and castanospermine as an inhibitor of glycoprotein processing.

The hybrid and/or core polypeptides of the invention may, further, be utilized prophylactically for the prevention of disease. Hybrid and/or core polypeptides can act directly to prevent disease or, alternatively, can be used as vaccines, wherein the host raises antibodies against the hybrid polypeptides of the invention, which then serve to neutralize pathogenic organisms including, for example, inhibiting viral, bacterial and parasitic infection.

For all such treatments described above, the exact formulation, route of administration and dosage can be chosen by the individual physician in view of the patient's condition. (See e.g. Fingl et al., 1975, in “The Pharmacological Basis of Therapeutics”, Ch. 1 p1).

It should be noted that the attending physician would know how to and when to terminate, interrupt, or adjust administration due to toxicity, or to organ dysfunctions. Conversely, the attending physician would also know to adjust treatment to higher levels if the clinical response were not adequate (precluding toxicity). The magnitude of an administrated dose in the management of the oncogenic disorder of interest will vary with the severity of the condition to be treated and the route of administration. The dose and perhaps dose frequency, will also vary according to the age, body weight, and response of the individual patient. A program comparable to that discussed above may be used in veterinary medicine.

Use of pharmaceutically acceptable carriers to formulate the compounds herein disclosed for the practice of the invention into dosages suitable for systemic administration is within the scope of the invention. With proper choice of carrier and suitable manufacturing practice, the compositions of the present invention, in particular, those formulated as solutions, may be administered parenterally, such as by intravenous injection. The compounds can be formulated readily using pharmaceutically acceptable carriers well known in the art into dosages suitable for oral administration. Such carriers enable the compounds of the invention to be formulated as tablets, pills, capsules, liquids, gels, syrups, slurries, suspensions and the like, for oral ingestion by a patient to be treated.

Pharmaceutical compositions suitable for use in the present invention include compositions wherein the active ingredients are contained in an effective amount to achieve its intended purpose. Determination of the effective amounts is well within the capability of those skilled in the art, especially in light of the detailed disclosure provided herein.

In addition to the active ingredients, these pharmaceutical compositions may contain suitable pharmaceutically acceptable carriers comprising excipients and auxiliaries which facilitate processing of the active compounds into preparations which can be used pharmaceutically. The preparations formulated for oral administration may be in the form of tablets, dragees, capsules, or solutions.

The pharmaceutical compositions of the present invention may be manufactured in a manner that is itself known, e.g., by means of conventional mixing, dissolving, granulating, dragee-making, levigating, spray drying, emulsifying, encapsulating, entrapping or lyophilizing processes.

Pharmaceutical formulations for parenteral administration include aqueous solutions of the active compounds in water-soluble form. Additionally, emulsions and suspensions of the active compounds may be prepared as appropriate oily injection mixtures. Suitable lipophilic solvents or vehicles include fatty oils such as sesame oil, or synthetic fatty acid esters, such as ethyl oleate or triglycerides, liposomes or other substances known in the art for making lipid or lipoptilic emulsions. Aqueous injection suspensions may contain substances which increase the viscosity of the suspension, such as sodium carboxymethyl cellulose, sorbitol, or dextran. Optionally, the suspension may also contain suitable stabilizers or agents which increase the solubility of the compounds to allow for the preparation of highly concentrated solutions.

Pharmaceutical preparations for oral use can be obtained by combining the active compounds with solid excipient, optionally grinding a resulting mixture, and processing the mixture of granules, after adding suitable auxiliaries, if desired, to obtain tablets or dragee cores. Suitable excipients are, in particular, fillers such as sugars, including lactose, sucrose, trehalose, mannitol, or sorbitol; cellulose preparations such as, for example, maize starch, wheat starch, rice starch, potato starch, gelatin, gum tragacanth, methyl cellulose, hydroxypropylmethyl-cellulose, sodium carboxymethylcellulose, and/or polyvinylpyrrolidone (PVP). If desired, disintegrating agents may be added, such as the cross-linked polyvinyl pyrrolidone, agar, or alginic acid or a salt thereof such as sodium alginate.

Dragee cores are provided with suitable coatings. For this purpose, concentrated sugar solutions may be used, which may optionally contain gum arabic, talc, polyvinyl pyrrolidone, carbopol gel, polyethylene glycol, and/or titanium dioxide, lacquer solutions, and suitable organic solvents or solvent mixtures. Dyestuffs or pigments may be added to the tablets or dragee coatings for identification or to characterize different combinations of active compound doses.

Pharmaceutical preparations which can be used orally include push-fit capsules made of gelatin, as well as soft, sealed capsules made of gelatin and a plasticizer, such as glycerol or sorbitol. The push-fit capsules can contain the active ingredients in admixture with filler such as lactose, binders such as starches, and/or lubricants such as talc or magnesium stearate and, optionally, stabilizers. In soft capsules, the active compounds may be dissolved or suspended in suitable liquids, such as fatty oils, liquid paraffin, or liquid polyethylene glycols. In addition, stabilizers may be added.

In instances where an enhancement of the host immune response is desired, the hybrid polypeptides may be formulated with a suitable adjuvant in order to enhance the immunological response. Such adjuvants may include, but are not limited to mineral gels such as aluminum hydroxide; surface active substances such as lysolecithin, pluronic polyols, polyanions; other peptides; oil emulsions; and potentially useful human adjuvants such as BCG and Corynebacterium parvum. Many methods may be used to introduce the vaccine formulations described here. These methods include but are not limited to oral, intradermal, intramuscular, intraperitoneal, intravenous, subcutaneous, and intranasal routes.

6. EXAMPLE

IDENTIFICATION OF CONSENSUS AMINO ACID SEQUENCES THAT COMPRISE ENHANCER PEPTIDE SEQUENCES

The retroviral gp41protein contains structural domains referred to as the α-helix region located in the C-terminal region of the protein and the leucine zipper region located in the N-terminal region of the protein. Alignment of the enhancer sequence regions contained within gp41( FIGS. 2A and 2B ) of gp41from all currently published isolate sequences of HIV-1, HIV-2 and SIV identified the consensus amino acid sequences shown in FIG. 1 .

As described in detail in the Examples presented below, such sequences represent enhancer peptide sequences in that linkage of these peptide sequences to a variety of different core polypeptides enhances the pharmacokinetic properties of the resultant hybrid polypeptides.

7. EXAMPLE

HYBRID POLYPEPTIDES THAT FUNCTION AS POTENT INHIBITORS OF HIV-1 INFECTION

T1249, as depicted in FIG. 13 , is a hybrid polypeptide comprising enhancer peptide sequences linked to an HIV core polypeptide. As demonstrated below, the T1249 hybrid polypeptide exhibits enhanced pharmacokinetic properties and potent in vitro activity against HIV-1, HIV-2, and SIV isolates, with enhanced activity against HIV-1 clinical isolates in HuPBMC infectivity assays in vitro as well as in the HuPBMC SCID mouse model of HIV-1 infection in vivo. In the biological assays described below, the activity of the T1249 is compared to the potent anti-viral T20 polypeptide. The T20 polypeptide, also known as DP-178, is derived from HIV-1 gp41 protein sequence, and is disclosed and claimed in U.S. Pat. No. 5,464,933.

7.1. Materials and Methods

7.1.1. Peptide Synthesis and Purification

Peptides were synthesized using Fast Moc chemistry. Generally, unless otherwise noted, the peptides contained amidated carboxyl termini and acetylated amino termini. Purification was carried out by reverse phase HPLC.

T1249 (Ac-WQEWEQKITALLEQAQIQQEKNEYELQKLDKWASL WEWF-NH 2 ) (SEQ ID: 1071) is a 39 amino acid peptide (MW=5036.7) composed entirely of naturally occurring amino acids and is blocked at the amino terminus by an acetyl group and the carboxyl terminus is blocked by an amido group to enhance stability. T1387 is a 23 amino acid peptide lacking enhancer peptide sequences (Ac-TALLEQAQIQQEKNEYELQKLDK-NH 2 ) (SEQ ID: 1286). Thus, T1387 represents the core polypeptide of the T1249 hybrid polypeptide. T1387 is blocked at its amino- and carboxy-termini in the same manner as T1249.

In particular, T1249 was synthesized using standard solid-phase synthesis techniques. The identity of the principal peak in the HPLC trace was confirmed by mass spectroscopy to be T1249.

T1249 was readily purified by reverse phase chromatography on a 6-inch column packed with a C18, 10 micron, 120A support.

7.1.2. Virus

The HIV-1 LAI virus (Popovic, M. et al., 1984, Science 224:497-508) was propagated in CEM cells cultured in RPMI 1640 containing 10% fetal calf serum. Supernatant from the infected CEM cells was passed through a 0.2 μm filter and the infectious titer estimated in a microinfectivity assay using the AA5 cell line to support virus replication. For this purpose, 20 μl of serially diluted virus was added to 20 μl CEM cells at a concentration of 6×10 5 /ml in a 96-well microtitre plate. Each virus dilution was tested in triplicate. Cells were cultured for seven days by addition of fresh medium every other day. On day 7 post infection, supernatant samples were tested for virus replication as evidenced by reverse transcriptase activity released to the supernatant. The TCID 50 was calculated according to the Reed and Muench formula (Reed, L. J. et al., 1938, Am. J. Hyg. 27:493-497).

7.1.3. Cell Fusion Assay

Approximately 7×10 4 Molt-4 cells were incubated with 1×10 4 CEM cells chronically infected with the HIV-1 LAI virus in 96-well tissue culture plates in a final volume of 100 μl culture medium (RPM11640 containing 10% heat inactivated FBS, supplemented with 1% L-glutamine and 1% Pen-Strep) as previously described (Matthews, T. J. et al., 1987, Proc. Natl. Acad. Sci. USA 84: 5424-5428). Peptide inhibitors were added in a volume of 10 μl and the cell mixtures were incubated for 24 hr. at 37° C. in 5% CO 2 . At that time, multinucleated giant cells (syncytia, five cell widths or larger) were counted by microscopic examination at 10× and 40×magnification which allowed visualization of the entire well in a single field. Treated cells were compared to infected, untreated controls and results expressed as percent inhibition of infected controls.

7.1.4. Magi-CCR-5 Infectivily Assays

Approximately 1×10 6 Magi-CCR-5 cells (obtained through the NIH AIDS Research and Reference Reagent Program, Division of AIDS, NIAID; Chackerian, B. et al., 1997, J. Virol. 71: 3932-3939) were seeded into a 48-well tissue culture plate (approximately 2×10 4 cells/well in a volume of 300 μl/well selective growth medium consisting of DMEM supplemented with 10% heat inactivated FBS, 1% L-glutamine, 1% Pen/Strep, Hygromycin B, Geneticin, and Puromycin) and allowed to attach overnight at 37° C., 5% CO 2 . Cell confluency was approximately 30% by the following day. Seeding medium was removed and diluted peptide inhibitor added in volumes of 50 μl/well (media only in untreated controls), followed by 100 μl/well of diluted virus (desired input virus titre of 100-200 pfu/well). Finally, 250 μl of selective growth medium was added to each well and the plate incubated for 2 days at 37° C., 5% CO 2 . Fixing and staining were done according to the 30 protocol provided by NIAID with the MAGI-CCR5 cells. Briefly, medium was removed from the plate and 500 μl of fixative added to each well. Plates were allowed to fix for 5 minutes at room temp. Fixative was removed, each well washed twice with DPBS, and 200 μl of staining solution added to each well. The plate was then incubated at 37° C., 5% CO 2 , for 50 minutes, staining solution removed, and each well washed twice with DPBS. The plate was allowed to air dry before blue cells were counted by microscopic, enumerating the entire well. Treated wells were compared to infected, untreated controls and results expressed as percent inhibition of infected controls.

7.1.5. Reverse Transcriptase Assay

The micro-reverse transcriptase (RT) assay was adapted from Goff et al. (Goff, S. et al., 1981, J. Virol. 38: 239-248) and Willey et al. (Willey, R. et al., 1988, J. Virol. 62: 139-147). Supernatants from virus/cell cultures were adjusted to 1% Triton-X100. 10 ul of each supernatant/Triton X-100 sample were added to 50 ul of RT cocktail (75 mM KCl, 2 mM Clevelands reagent, 5 mM MgCl 2 , 5 μg/ml poly A, 0.25 units/ml oligo dT, 0.05% NP40, 50 mM Tris-HCl, pH 7.8, 0.5 μM non-radioactive dTTP, and 10 cCi/ml 32 P-dTTP) in a 96-well U-bottom microtitre plate and incubated at 37° C. for 90 min. After incubation, 40 μl of reaction mixture from each well was transferred to a Schleicher and Schuell (S+S) dot blot apparatus, under partial vacuum, containing a gridded 96-well filter-mat (Wallac catalog #1450-423) and filter backing saturated with 2×SSC buffer (0.3M NaCl and 0.003M sodium citrate). Each well was washed 4 times with at least 200 μl 2×SSC using full vacuum. Minifold was disassembled and gridded filter paper removed and washed 3 times with 2×SSC. Finally, the filter membrane was drained on absorbent paper, allowed to air dry, and sealed in heat sealable bags. Samples were placed in a phosphorscreen cassette and an erased (at least 8 min) phosphorscreen applied and closed. Exposure was for 16 hr. Pixel Index Values (PIV), generated in volume reporting format retrieved from phosphorimaging (Molecular Dynamics Phosphorimager) blots, were used to determine the affected or inhibited fraction (Fa) for all doses of inhibitor(s) when compared to untreated, infected controls (analyzed by ImageQuant volume report, corrected for background).

7.1.6. Human PBMC Infectivity/Neutralization Assay

The prototypic assay used cell lines where the primary isolate assay utilizes PBMC, obtained through Interstate Blood Bank, activated for 2-3 days with a combination of OKT3 (0.5 μ/ml) and CD28 antibodies (0.1 μ/ml). The target cells were banded on lymphocyte separation medium (LSM), washed, and frozen. Cells were thawed as required and activated as indicated above a minimum of 2-3 days prior to assay. In this 96-well format assay, cells were at a concentration of 2×10 6 /ml in 5% IL-2 medium and a final volume of 100 μl. Peptide stock solutions were made in DPBS (1 mg/ml). Peptide dilutions were performed in 20% FBS RPM1 1640/5% IL-2 complete medium.

7.1.7. In Vivo HU-PBMC SCID Model of HIV-1 Infection

Female SCID mice (5-7 weeks old) received 5-10×10 7 adult human PBMC injected intraperitoneally. Two weeks after reconstitution, mice were infected IP on day 0 with 10 3 TCID 50 HIV-1 9320 (AZT-sensitive isolate A018). Treatment with peptides was IP, bid, beginning day-1 and continuing through day 6. The extent of infection in blood cells, splenocytes, lymph nodes, and peritoneal cells was assayed by quantitative co-culture with human PBMC blasts weekly for three consecutive weeks following animal exanguinations and tissue harvest (day 7, approximately 12-18 hours following the last drug treatment). Co-culture supernatants were evaluated for HIV-1 p24 antigen production as a measure of virus infection (Immunotek Coulter kits and protocol).

7.1.8. Rat Pharmacokinetic Studies

250-300 g male CD rats, double jugular catheter, obtained from Charles River Laboratories were used. Peptides were injected in one jugular catheter in a volume of 200 μl of peptide solution (approximately 3.75 mg/ml), dosing solution concentration was determined using the Edelhoch method, (Edelhoch, 1967, Biochemistry 6:1948-1954) method and adjusted based on animal weight such that each animal received a dose of 2.5 mg/kg). Approximately 250-300 μl of blood was removed at predetermined time intervals (0, 15, 30 min and 1,2,4, 6, and 8 hours) and added to EDTA capiject tubes. Plasma was removed from pelleted cells upon centrifugation and either frozen or immediately processed for fluorescence HPLC analysis.

7.1.9. Fluorescence HPLC Analysis of Plasma Samples

100 μl of sample plasma was added to 900 μl of precipitation buffer (acetonitrile, 0.1% TFA, detergent) resulting in precipitation of the majority of plasma proteins. Following centrifugation at 10,000 rpm for 10 min, 400 μl of the supernatant was removed and added to 600 μl of HPLC grade water. Serial dilutions were performed as dictated by concentration of peptide present in each sample in dilution buffer comprised of 40% precipitation buffer and 60% HPLC water. In addition to sample dilutions, serial dilutions of dosing solution were performed in buffer as well as in plasma and used to generate a standard curve relating peak area to known concentration of peptide. This curve was then used to calculate concentration of peptide in plasma taking into account all dilutions performed and quantity injected onto column.

7.1.10. XTT Protocol

In order to measure cytotoxic/cytostatic effects of peptides, XTT assays (Weislow, O. S. et al., 1989, J. Natl. Cancer Inst. 81:577-586) were performed in the presence of varying concentrations of peptide in order to effectively establish a selective index (SI). A TC 50 was determined in this assay by incubating cells in the presence and absence of serially diluted peptide followed by the addition of XTT. In surviving/metabolizing cells XTT is reduced to a soluble brown dye, XTT-formazan. Absorbance is read and comparisons made between readings in the presence and absence of peptide to determine a TC 50 utilizing the Karber method (see. e.g., Lennette, E. H. et al., eds., 1969, “Diagnostic Procedures for Viral and Rickettsial Infections, ” American Public Health Association, Inc., fourth ed., pp. 47-52). Molt 4, CEM (80,000 cells/well) and a combination of the two cell types (70,000 and 10,000 respectively) were plated and incubated with serially diluted peptide for 24 hours in a total volume of 100 μl. Following incubation, 25 μl of XTT working stock (1 mg/ml XTT, 250 μM PMS in complete medium containing 5% DMSO) was added to each well and the plates incubated at 37° C. Color development was read and results used to express values generated from peptide containing wells as a percentage of the untreated control wells.

7.2. Results

7.2.1. Antiviral Activity—Fusion Assays

T1249 was directly compared to T20 in virus mediated cell-cell fusion assays conducted using chronically infected CEM cells mixed with uninfected Molt-4 cells, as shown in Table 2, below. T1249 fusion inhibition against lab isolates such as IIIb, MN, and RF is comparable to T20, and displays an approximately 2.5-5-fold improvement over T20. T1249 was also more active (3-28 fold improvement) than T20 against several syncytia-inducing clinical isolates, including an AZT resistant isolate (G691-2), a pre-AZT treatment isolate (G762-3), and 9320 (isolate used in HuPBMC-SCID studies). Most notably, T1249 was over 800-fold more potent than T20 against HIV-2 NIHZ.

TABLE 2
	T20		T1249		Fold
Virus Isolate	(ng/ml)	n	(ng/ml)	n	Difference
HIV-1 IIIb	2.5	9	1.0	9	2.5
HIV-1 G691-2 (AZT-R)	406.0	1	16.0	1	25
HIV-1 G762-3 (Pre-	340.1	1	12.2	1	28
AZT)
HIV-1 MN	20.0	7	3.1	7	6
HIV-1 RF	6.1	7	2.1	7	3
HIV-1 9320	118.4	1	34.5	1	3
HIV-2 NIHZ	3610.0	>10	4.3	2	840

7.2.2. Antiviral Activity-Magi-CCR-5 Infectivity Assays

Magi-CCR-5 infectivity assays allow direct comparisons to be made of syncytia and non-syncytia inducing virus isolates, as well as comparisons between laboratory and clinical isolates. The assay is also a direct measure of virus infection (TAT expression following infection, transactivating an LTR driven beta-galactosidase production), as opposed to commonly used indirect measures of infectivity such as p24 antigen or reverse transcriptase production. Magi-CCR-5 infectivity assays (see Table 3 below) reveal that T1249 is consistently more effective than T20 against all isolates tested, in terms of both EC 50 and Vn/Vo=0.1 inhibition calculations. T1249 shows considerable improvement in potency against the clinical isolate HIV-1 301714 (>25-fold), which is one of the least sensitive isolates to T20. In addition, T1249 is at least 100-fold more potent than T20 against the SIV isolate B670. These data, along with fusion data suggest that T1249 is a potent peptide inhibitor of HIV-1, HIV-2, and SIV.

TABLE 3
					EC-50
					Fold	Vn/Vo =
Virus		Vn/Vo =	EC-	Vn/Vo =	Dif-	0.1 Fold
Isolate	EC-50	0.1	50	0.1	ference	Difference
HIV-1
IIIB	42	80	8	10	5	8
9320	11	50	1	6	11	8
301714	1065	4000	43	105	25	38
(subtype
B, NSI)
G691-2	13	200	0.3	20	43	10
(AZT-R)
pNL4-3	166	210	1	13	166	16
SIV-B670	2313	>1000	21	100	110	>100
		0

7.2.3. Antiviral Activity—HuPBMC Infectivity Assays

T1249 was directly compared to T20 in HuPBMC infectivity assays (Table 4, below), which represent a recognized surrogate in vitro system to predict plasma drug concentrations required for viral inhibition in vivo. These comparisons revealed that T1249 is more potent against all HIV-1 isolates tested to date, with all Vn/Vo=0.1 (dose required to reduce virus titer by one log) values being reduced to sub-microgram concentrations. Many of the least sensitive clinical isolates to T20 exhibited 10-fold or greater sensitivity to T1249. It is noteworthy that HIV-1 9320, the isolate used in the HuPBMC SCID mouse model of infection, is 46-fold less sensitive to T20 than to T1249, indicating a very good correlation with the in vivo results.

TABLE 4
	T20	T1249
	Vn/Vo = 0.1	Vn/Vo = 0.1	Fold
Virus Isolate (HIV-1	(ng/ml)	(ng/ml)	Difference
IIIB	250	80	3
9320	6000	130	46
301714 (subtype B,	8000	700	11
NSI)
302056 (subtype B,	800	90	9
NSI)
301593 (subtype B, SI)	3500	200	18
302077 (subtype A)	3300	230	14
302143 (SI)	1600	220	7
G691-2 (AZT-R)	1300	400	3

7.2.4. Antiviral Activity—T20 Resistant Lab Isolates

T1249 was directly compared to T20 in virus mediated cell-cell fusion assays conducted using chronically infected CEM cells mixed with uninfected Molt-4 cells (Table 5, below). T1249 was nearly 200-fold more potent than T20 against a T20-resistant isolate.

	TABLE 5
	Virus	T20		T1249		Fold
	Isolate	(ng/ml)	n	(ng/ml)	n	Difference
	HIV-1 pNL4-3 SM	405.3	3	2.1	3	193

In Magi-CCR-5 assays (see Table 6, below), T1249 is as much as 50,000-fold more potent than T20 against T20-resistant isolates such as pNL4-3 SM and pNL4-3 STM (Rimsky, L. and Matthews, T., 1998, J. Virol. 72:986-993).

TABLE 6
					EC-50	Vn/Vo =
		T20		T1249	Fold	0.1 Fold
Virus		Vn/Vo =	EC-	Vn/Vo =	Dif-	Dif-
Isolate	EC-50	0.1	50	0.1	ference	ference
HIV-1
pNL4-3	166	210	1	13	166	16
pNL4-3	90	900	4	11	23	82
SM
(T20-R)
pNL4-3	410	2600	4	11	103	236
SM
(T20-R)
Duke
pNL4-3	>5000	>5000	1	13	>50000	>3846
STM	0	0
(T20/
T649-R)
Duke

T1249 was directly compared to T20 in HUPBMC infectivity assays (see Table 7, below), evaluating differences in potency against a resistant isolate. T1249 is greater than 250-fold more potent than T20 against the resistant isolate pNL4-3SM.

	TABLE 7
		T20	T1249
		Vn/Vo = 0.1	Vn/Vo = 0.1	Fold
	Virus Isolate (HIV-1	(ng/ml)	(ng/ml)	Difference
	HIV-1
	pNL4-3	3500	30	117
	pNL4-3 SM (T20-R)	>10000	40	>250

7.2.5. Antiviral Activity—In Vivo SCID-HuPBMC Model

In vivo antiviral activity of T1249 was directly compared to T20 activity in the HuPBMC-SCID mouse model of HIV-1 9320 infection (FIG. 3 ). Two weeks after reconstitution with HuPBMCs, mice were infected IP on day 0 with 10 3 TCID 50 HIV-1 9320 passed in PBMCs (AZT-sensitive isolate A018). Treatment with peptides was IP, bid, for total daily doses of 67 mg/kg (T20), 20 mg/kg (T1249), 6.7 mg/kg (T1249), 2.0 mg/kg (T1249), and 0.67 mg/kg (T1249), for 8 days beginning on day-1. The extent of infection in blood cells, splenocytes, lymph nodes, and peritoneal cells was assayed by quantitative co-culture with human PBMC blasts weekly for three consecutive weeks following animal exanguinations and tissue harvest (day 7, approx. 12 to 18 hours following last drug treatment). Co-culture supernatants were evaluated for HIV-1 p24 antigen production as a measure of virus infection. Infectious virus was not detectable in the blood or lymph tissues of the T20-treated animals, although, virus was detected in the peritoneal washes and spleen preparation. All compartments were negative for infectious virus at the 6.7 mg/kg dose of T1249, indicating at least a 10-fold improvement over T20 treatment. At the 2.0 mg/kg dose of T1249, both the lymph and the spleen were completely free of detectable infectious virus, with a 2 log 10 reduction in virus titer in the peritoneal wash and a 1 log 10 reduction in virus titer in the blood, compared to infected controls. At the lowest dose of T1249, 0.67 mg/kg, the peritoneal washes and blood were equivalent to infected control; however, at least a 1 log 10 drop in infectious virus titer was observed in both the lymph and the spleen tissues. Overall, the results indicate that T1249 is between 30 and 100-fold more potent against HIV-1 9320, in vivo, under these conditions.

7.2.6. Pharmacokinetic Studies—Rat

Cannulated rats were used to further define the pharmacokinetic profile of T1249. Male CD rats, 250-300 g, were dosed IV through a jugular catheter with T1249 and T20 (FIGS. 4 A- 5 ). The resulting plasma samples were evaluated using fluorescence HPLC to estimate peptide quantities in extracted plasma. The beta-phase half-life and total AUC of T1249 was nearly three times greater than T20 (FIG. 5 ).

7.2.7. Cytotosicity

No overt evidence of T1249 cytotoxicity has been observed in vitro, as demonstrated in FIG. 6 .

In addition, T1249 is not acutely toxic (death within 24 hours) at 167 mg/kg (highest dose tested) given IV through jugular cannula (0.3 ml over 2-3 min).

7.2.8. Direct Binding to gp41 Construct M41 Δ178

T1249 was radiolabelled with 125 I and HPLC- purified to maximum specific activity. T20 was iodinated in the same manner. Saturation binding of to M41Δ178 (a truncated gp41 actodomain fusion protein lacking the T20 amino acid sequence) immobilized on microtitre plates at 0.5 gm/μl is shown in FIG. 7 . Nonspecific binding was defined as binding of the radioligand in the presence of 1 μM unlabeled peptide. Specific binding was the difference between total and nonspecific binding. The results demonstrate that 125 I-T1249 and 125 I-T20 have similar binding affinities of 1-2 nM. Linear inverse Scatchard plots suggests that each ligand binds to a homogeneous class of sites.

The kinetics of 125 I-T1249 and 125 I-T20 binding was determined on scintillating microtitre plates coated with 0.5 μg/ml M41Δ178. The time course for association and dissociation is shown in FIG. 8 . Dissociation of bound radioligand was measured following the addition of unlabeled peptide to a final concentration of 10 μM in one-tenth of the total assay volume. Initial on- and off-rates for 125 I-T1249 were significantly slower than those of 125 I-T20. Dissociation patterns for both radioligands were unchanged when dissociation was initiated with the other unlabeled peptide (i.e., 125 I-T1249 with T20).

To further demonstrate that both ligands compete for the same target site, unlabeled T1249 and T20 were titrated in the presence of a single concentration of either 125 I-T1249 or 125 I-T20. Ligand was added just after the unlabeled peptide to start the incubation. The competition curves shown in FIG. 9 suggest that although both ligands have similar affinities, a higher concentration of unlabeled peptide is required to fully compete for bound 125 I-T1249.

8. EXAMPLE

RESPIRATORY SYNCYTIAL VIRUS HYBRID POLYPEPTIDES

The following example describes respiratory syncytial irus (RSV) hybrid polypeptides with enhanced pharmacokinetic roperties. In addition, results are presented, below, which demonstrate that the RSV hybrid polypeptides represent potent inhibitors of RSV infection.

8.1. Materials and Methods

8.1.1. Peptide-Synetheis and Purification

RSV polypeptides were synthesized using standard Fast Moc chemistry. Generally, unless otherwise noted, the peptides contained amidated carboxyl termini and acetylated amino termini. Purification was carried out by reverse phase HPLC.

8.1.2. Respiratory Syncytial Virus Plaque Reduction Assay

All necessary dilutions of peptides were performed in clean, sterile 96-well TC plate. A total of eleven dilutions for each peptide and one control well containing no peptide were assembled. The final concentration range of peptide started at 50 μg/ml or 100 μg/ml, with a total of eleven two-fold dilutions. The RSV was prepared at a concentration of 100PFU/well in 100 μl 3% EMEM, as determined by a known titer of RSV. The virus is then added to all of the wells.

The media was removed from one sub-confluent 96-well plate of Hep2 cells. The material from the dilution plate was transferred onto the cell plates starting with row 1 and then transferring row 12, row 11, etc. until all rows were transferred. Plates were placed back into the incubator for 48 hours.

The cells were checked to ensure that syncytia were present in the control wells. Media was removed and approximately 50 μls of 0.25% Crystal Violet in methanol was added to each well. The wells were rinsed immediately in water to remove excess stain and allowed to dry. Using a dissecting microscope, the number of syncytia in each well was counted.

8.2. RESULTS

Pharmacokinetic studies with the RSV hybrid peptides T1301 (Ac-WQEWDEYDASISQVNEKINQALAYIREADELWA WF-NH 2 ) (SEQ ID NO:1434) and T1302 (Ac-WQAWDEYDASISQVNEKINQALAYIREADELW AWF-NH 2 ) (SEQ ID NO:1435) containing enhancer peptide sequences demonstrated a greatly enhanced half-life relative to core peptide T786 (Ac-VYPSDEYDASISQVNEEINQALAYIRKADELLENV-NH 2 ) (SEQ ID NO:1312), as demonstrated in FIGS. 10A-10B . Hybrid polypeptides T1301, T1302 and T1303 WQAWDEYDASISQVNEKINQALAYIREADELWEWF (SEQ ID NO:1124) also showed a greatly enhanced half-size relative to core peptide T1476 (Ac-DEYDASISQVNEKINQALAYIREADEL-NH 2 ) (SEQ ID NO:1340).

RSV hybrid polypeptides T1301, T1302 and T1303, as well as polypeptide T786 and T1293, were tested for their ability to inhibit RSV plaque formation of HEp2 cells. As indicated in FIGS. 11A and 11B , both the tested hybrid RSV polypeptides, as well as the T786 core polypeptide were able to inhibit RSV infection. Surprisingly, the T1293 hybrid polypeptide was also revealed to be a potent anti-RSV compound (FIG. 13 ).

9. EXAMPLE

LUTEINIZING HORMONE HYBRID POLYPEPTIDES

The example presented herein describes luteinizing hormone (LH) hybrid proteins with enhanced pharmacokinetic properties. The following LH hybrid peptides were synthesized and purified using the methods described above: core peptide T1323 (Ac-QHWSYGLRPG-NH 2 ) (SEQ ID NO:1309) and hybrid polypeptide T1324 (Ac-WQEWEQKIQHWSYGLRPGWASLWEWF-NH 2 ) (SEQ ID NO:1144) which comprises the core polypeptide T1323 amino acid sequence coupled with enhancer peptides at its amino- and carboxy-termini. As demonstrated in FIGS. 12A and 12B , the T1324 hybrid peptide exhibited a significantly increased half-life when compared to the T1323 core peptide which lacks the enhancer peptide sequences.

The present invention is not to be limited in scope by the specific embodiments described herein, which are intended as single illustrations of individual aspects of the invention, and functionally equivalent methods and components are within the scope of the invention. Indeed, various modifications of the invention, in addition to those shown and described herein will become apparent to those skilled in the art from the foregoing description and accompanying drawings. Such modifications are intended to fall within the scope of the appended claims.

TABLE 1
T		Seq.
No.	Sequence	ID No.
1	GIKQLQARILAVERYLKDQ	1
2	NNLLRAIEAQQHLLQLTVW	2
3	NEQELLELDKWASLWNWF	3
4	YTSLIHSLIEESQNQQEK	4
5	Ac-VWGIKQLQARILAVERYLKDQQLLGIWG-NH2	5
6	QHLLQLTVWGIKQLQARILAVERYLKDQ	6
7	LRAIEAQQHLLQLTVWGIKQLQARILAV	7
8	VQQQNNLLARIEAQQHLLQLTVWGIKQL	8
9	RQLLSGIVQQQNNLLRAIEAQQHLLQLT	9
10	MTLTVQARQLLSGIVQQQNNLLRAIEAQ	10
12	VVSLSNGVSVLTSKVLDLKNYIDKQLL	11
13	LLSTNKAVVSLSNGVSVLTSKVLDLKNY	12
15	Ac-VLHLEGEVNKIKSALLSTKKAVVSLSNG-NH2	13
19	Ac-LLSTNKAVVSLSNGVSVLTSKVLDLKNY-NH2	14
20	Ac-YTSLIHSLIEESQNQQEKNEQELLELDKWASLWNWF-NH2	15
21	Ac-NNLLRAIEAQQHLLQLTVWGIKQLQARILAVERYLKDQ-NH2	16
22	Ac-IELSNIKENKCNGTDAKVKLIKQELDKYKNAVTELQLLMQST-NH2	17
23	Ac-IELSNIKENKCNGTDAKVKLIKQELDKY-NH2	18
24	Ac-ENKCNGTDAKVKLIKQELDKYKNAVTEL-NH2	19
25	Ac-DAKVKLIKQELDKYKNAVTELQLLMQST-NH2	20
26	Ac-CNGTDAKVKLIKQELDKYKNAVTELQLL-NH2	21
27	Ac-SNIKENKCNGTDAKVKLIKQELDKYKNAVTELQLL-NH2	22
28	Ac-ASGVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGV-NH2	23
29	Ac-SGVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNG-NH2	24
30	Ac-VLHLEGEVNKIKSALLSTHKAVVSLSNGVSVLTSK-NH2	25
31	Ac-ARKLQRMKQLEDKVEELLSKNYHYLENEVARLKKLV-NH2	26
32	Ac-RMKQLEDKVEELLSKNYHYLENEVARLKKLVGER-NH2	27
33	Ac-VQQQNNLLRAIEAQQHLLQLTVWGIKQL-NH2	28
34	Ac-LRAIEAQQHLLQLTVWGIKQLQARILAV-NH2	29
35	Ac-QHLLQLTVWGIKQLQARILAVERYLKDQ-NH2	30
36	Ac-RQLLSGIVQQQNNLLRAIEAQQHLLQLT-NH2	31
37	Ac-MTLTVQARQLLSGIVQQQNNLLRAIEAQ-NH2	32
38	Ac-AKQARSDIEKLKEAIRDTNKAVQSVQSS-NH2	33
39	Ac-AAVALVEAKQARSDIEKLKEAIRDTNKAVQSVQSS-NH2	34
40	Ac-AKQARSDIEKLKEAIRDTNKAVQSVQSSIGNLIVA-NH2	35
41	Ac-GTIALGVATSAQITAAVALVEAKQARSD-NH2	36
42	Ac-ATSAQITAAVALVEAKQARSDIEKLKEA-NH2	37
43	Ac-AAVALVEAKQARSDIEKLKEAIRDTNKANH2	38
44	Ac-IEKLKEAIRDTNKAVQSVQSSIGNLIVA-NH2	40
45	Ac-IRDTNKAVQSVQSSIGNLIVAIKSVQDY-NH2	41
46	Ac-AVQSVQSSIGNLIVAIKSVQDYVNKEIV-NH2	42
47	Ac-QARQLLSGIVQQQNNLLRAIEAQQHLLQLTVWGIKQLARILAVERYLKDQ-NH2	43
48	Ac-QARQLLSGIVQQQNNLLRAIEAQQHLLQ-NH2	44
49	Ac-MTWMEMDREINNYTSLIGSLIEESQNQQEKNEQELLELDKWASLWNWF-NH2	45
50	Ac-WMEWDREINNYTSLIGSLIEESQNQQEKNEQELLE-NH2	46
51	Ac-INNYTSLIGSLIEESQNQQEKNEQELLE-NH2	47
52	Ac-INNYTSLIGSLIEESQNQQEKNEQELLELDKWASL-NH2	48
53	Ac-EWDREINNYTSLIGSLIEESQNQQEKNEQEGGC-NH2	49
54	Ac-QSRTLLAGIVQQQQQLLDVVKRQQELLWNH2	50
55	Ac-NNDTWQEWERKVDFLEENITALLEEAQIQQEKNMYELQKLNSWD-NH2	51
56	Ac-WQEWERKVDFLEENITALLEEAQIQQEK-NH2	52
57	Ac-VDFLEENITALLEEAQIQQEKNMYELQK-NH2	53
58	Ac-ITALLEEAQIQQEKNMYELQKLNSWDVF-NH2	54
59	Ac-SSESFTLLEQWNNWKLQLAEQWLEQINEKHYLEDIS-NH2	55
60	Ac-DKWASLWNWF-NH2	56
61	Ac-NEQELLELDKWASLWNWF-NH2	57
62	Ac-EKNEQELLELDKWASLWNWF-NH2	58
63	Ac-NQQEKNEQELLELDKWASLWNWF-NH2	59
64	Ac-ESQNQQEKNEQELLELDKWASLWNWF-NH2	60
65	Ac-LIHSLIEESQNQQEKNEQELLELDKWASLWNWF-NH2	61
66	Ac-NDQKKLMSNNVQIVRQQSYSIMSIIKEE-NH2	62
67	Ac-DEFDASISQVNEKINQSLAFIRKSDELL-NH2	63
68	Ac-VSKGYSALRTGWYTSVITIELSNIKEN-NH2	64
69	Ac-VVSLSNGVSVLTSKVLDLKNYIDKQLL-NH2	65
70	Ac-VNKIKSALLSTNKAVVSLSNGVSVLTSK-NH2	66
71	Ac-PIINFYDPLVFPSDEFDASISQVNEKINQSLAFIR-NH2	67
72	Ac-NLVYAQLQFTYDTLRGYINRALAQIAEA-NH2	68
73	Ac-LNQVDLTETLERYQQRLNTYALVSKDASYRS-NH2	69
74	Ac-ELLVLKKAQLNRHSYLKDSDFLDAALD-NH2	70
75	Ac-LAEAGEESVTEDTEREDTEEEREDEEE-NH2	71
76	Ac-ALLAEAGEESVTEDTEREDTEEEREDEEEENEART-NH2	72
77	Ac-ETERSVDLVAALLAEAGEESVTEDTEREDTEEERE-NH2	73
78	Ac-EESVTEDTEREDTEEEREDEEEENEART-NH2	74
79	Ac-VDLVAALLAEAGEESVTEDTEREDTEEE-NH2	75
80	Ac-NSETERSVDLVAALLAEAGEESVTE-NH2	76
81	Ac-DISYAQLQFTYDVLKDYINDALRNIMDA-NH2	77
82	Ac-SNVFSKDEIMREYNSQKQHIRTLSAKVNDN-NH2	78
83	Biotin-YTSLIHSLIEESQNQQEKNEQELLELDKWASLWNWF-NH2	1076
84	Dig-YTSLIHSLIEESQNQQEKNEQELLELDKWASLWNWF-NH2	1076
85	Biotin-NNLLRAIEAQQHLLQLTVWGIKQLQARILAVERYLKDG-NH2	16
86	Dig-NNLLRAIEAQQHLLQLTVWGIKQLQARILAVERYLKDQ-NH2	16
87	Ac-VLHQLNIQLKQYLETQERLLAGNRIAARQLLQIWKDVA-NH2	83
88	Ac-LWHEQLLNTAQRAGLQLQLINQALAVREKVLIRYDIQK-NH2	84
89	Ac-LLDNFESTWEQSKELWEQQEISIQNLHKSALQEYW-NH2	85
90	Ac-LSNLLQISNNSDEWLEALEIEHEKWKLTQWQSYEQF-NH2	86
91	Ac-KLEALEGKLEALEGKLEALEGKLEALEGKLEALEGK-NH2	87
92	Ac-ELRALRGELRALRGELRALRGELRALRGK-NH2	88
93	Ac-ELKAKELEGEGLAEGEEALKGLLEKAAKLEGLELLK-NH2	89
94	Ac-WEAAAREAAAREAAAREAAARA-NH2	90
95	Ac-YTSLIHSLIEESQNQQEKNEQELLELDKWASLWNAF-NH2	91
96	Ac-YTSLIHSLIEESQNQQEKNEQELLELDKWASLANWF-NH2	92
97	Ac-YTSLIHSLIEESQNQQEKNQQELLELDKWASLWNWF-NH2	93
98	Ac-YTSLIHSLIEESQNQQEKNEQELLQLDKWASLWNWF-NH2	94
99	Ac-YTSLIHSLIEESQNQQEKNQQELLQLDKWASLWNWF-NH2	95
100	Ac-RMKQLEDKVEELLSKNYHLENEVARLKKLVGER-NH2	96
101	Ac-QQLLQLTVWGIKQLQARILAVERYLKNQ-NH2	97
102	Ac-NEQELLELDKWASLWNWF-NH2	98
103	Ac-YTSLIQSLIEESQNQQEKNEQELLELDKWASLWNWF-NH2	99
104	Ac-IINFYDPLVFPSDEFDASISQVNEKINQSLAFIRK-NH2	100
105	Ac-INFYDPLVFPSDEFDASISQVNEKINQSLAFIRKS-NH2	101
106	Ac-NFYDPLVFPSDEFDASISQVNEKINQSLAFIKKSD-NH2	102
107	Ac-FYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDE-NH2	103
108	Ac-YDPLVFPSDEFDASISQVNEKINQSLAFIRKSDEL-NH2	104
109	Ac-DPLVFPSDEFDASISQVNEKINQSLAFIRKSDELL-NH2	105
110	Ac-PLVFPSDEFDASISQVNEKINQSLAFIRKSDELLH-NH2	106
111	Ac-LVFPSDEFDASISQVNEKINQSLAFIRKSDELLHN-NH2	107
112	Ac-VFPSDEFDASISQVNEKINQSLAFIRKSDELLHNV-NH2	108
113	Ac-FPSDEFDASISQVNEKINQSLAFIRKSDELLHNVN-NH2	109
114	Ac-PSDEFDASISQVNEKINQSLAFIRKSDELLHNVNA-NH2	110
115	Ac-SDEFDASISQVNEKINQSLAFIRKSDELLHNVNAG-NH2	111
116	Ac-DEFDASISQVNEKINQSLAFIRKSDELLHNVNAGK-NH2	112
117	Ac-EFDASISQVNEKINQSLAFIPKSDELLHNVNAGKS-NH2	113
118	Ac-FDASISQVNEKINQSLAFIRKSDELLHNVNAGKST-NH2	114
119	Ac-DASISQVNEKINQSLAFIRKSDELLHNVNAGKSTT-NH2	115
120	Ac-ASGVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSN-NH2	116
121	Ac-SGVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNG-NH2	117
122	Ac-GVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGV-NH2	118
123	Ac-VAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVS-NH2	119
124	Ac-AVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSV-NH2	120
125	Ac-VSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVL-NH2	121
126	Ac-SKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLT-NH2	122
127	Ac-KVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTS-NH2	123
128	Ac-VLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTSK-NH2	124
129	Ac-LHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTSKV-NH2	125
130	Ac-HLEGEVNKIKSALLSTNKAVVSLSNGVSVLTSKVL-NH2	126
131	Ac-LEGEVNKIKSALLSTNKAVVSLSNGVSVLTSKVLD-NH2	127
132	Ac-EGEVNKIKSALLSTNKAVVSLSNGVSVLTSKVLDL-NH2	128
133	Ac-GEVNKIKSALLSTNKAVVSLSNGVSVLTSKVLDLK-NH2	129
134	Ac-EVNKIKSALLSTNKAVVSLSNGVSVLTSKVLDLKN-NH2	130
135	Ac-VNKIKSALLSTNKAVVSLSNGVSVLTSKVLDLKNY-NH2	131
136	Ac-NKIKSALLSTNKAVVSLSNGVSVLTSKVLDLKNYI-NH2	132
137	Ac-KIKSALLSTNKAVVSLSNGVSVLTSKVLDLKNYID-NH2	133
138	Ac-IKSALLSTNKAVVSLSNGVSVLTSKVLDLKNYIDK-NH2	134
139	Ac-KSALLSTNKAVVSLSNGVSVLTSKVLDLKNYIDKQ-NH2	135
140	Ac-SALLSTNKAVVSLSNQVSVLTSKVLDLKNYIDKQL-NH2	136
141	Ac-ALLSTNKAVVSLSNGVSVLTSKVLDLKNYIDKQLL-NH2	137
142	Ac-YTSVITIELSNIKENKCNGTDAKVKLIKQELDKYK-NH2	138
143	Ac-TSVITIELSNIKENKCNGTDAKVKLIKQELDKYKN-NH2	139
144	Ac-SVITIELSNIKENKCNGTDAKVKLIKQELDKYKNA-NH2	140
145	Ac-VITIELSNIKBNKCNGTDAKVKLIKQELDKYKNAV-NH2	141
146	Ac-ITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVT-NH2	142
147	Ac-TIELSMKENKCNGTDAKVKLIKQELDKYKNAVTE-NH2	143
148	Ac-IELSNIKENKCNGTDAKVKLIKQELDKYKNAVTEL-NH2	144
149	Ac-ELSNIKENKCNGTDAKVKLIKQELDKYKNAVTELQ-NH2	145
150	Ac-LSNIKENKCNGTDAKVKLIKQELDKYKNAVTELQL-NH2	146
151	Ac-SNIKENKCNGTDAKVKLIKQELDKYKNAVTELQLL-NH2	147
152	Ac-NIKENKCNGTDAKVKLIKQELDKYKNAVTELQLLM-NH2	148
153	Ac-IKENKCNGTDAKVKLIKQELDKYKNAVTELQLLMQ-NH2	149
154	Ac-KENKCNGTDAKVKLIKQELDKYKNAVTELQLLMQS-NH2	150
155	Ac-ENKCNGTDAKVKLIKQELDKYKNAVTELQLLMQST-NH2	151
156	Ac-LLDNFESTWEQSKELWELQEISIQNLHKSALQEYWN-NH2	152
157	Ac-ALGVATSAQITAAVALVEAKQARSDIEKLKEAIRD-NH2	153
158	Ac-LGVATSAQITAAVALVEAKQARSDIEKLKEAIRDT-NH2	154
159	Ac-GVATSAQITAAVALVEAKQARSDIEKLKEAIRDTN-NH2	155
160	Ac-VATSAQITAAVALVEAKQARSDIEKLKEAIRDTNK-NH2	156
161	Ac-ATSAQITAAVALVEAKQARSDIEKLKEAIRDTNKA-NH2	157
162	Ac-TSAQITAAVALVEAKQARSDIEKLKEAIRDTNKAV-NH2	158
163	Ac-SAQITAAVALVEAKQARSDIEKLKEAIRDTNKAVQ-NH2	159
164	Ac-AQITAAVALVEAKQARSDIEKLKEAIRDTNKAVQS-NH2	160
165	Ac-QITXAVALVEAKQARSDIEKLKEAIRDTNKAVQSV-NH2	161
166	Ac-ITAAVALVEAKQARSDIEKLKEAIRDTNKAVQSVQ-NH2	162
167	Ac-TAAVALVEAKQARSDIEKLKEAIRDTNKAVQSVQS-NH2	163
168	Ac-AAVALVEAKQARSDIEKLKEAIRDTNKAVQSVQSS-NH2	164
169	Ac-AVALVEAKQARSDIEKLKEAIRDTNKAVQSVQSSI-NH2	165
170	Ac-VALVEAKQARSDIEKLKEAIRDTNKAVQSVQSSIG-NH2	166
171	Ac-ALVEAKQARSDIEKLKEAIRDTNKAVQSVQSSIGN-NH2	167
172	Ac-LVEAKQARSDIEKLKEAIRDTNKAVQSVQSSIGNL-NH2	168
173	Ac-VEAKQARSDIEKLKEAIRDTNKAVQSVQSSIGNLI-NH2	169
174	Ac-EAKQARSDIEKLKEAIRDTNKAVQSVQSSIGNLIV-NH2	170
175	Ac-KQARSDIEKLKEAIRDTNKAVQSVQSSIGNLIVAI-NH2	171
176	Ac-QARSDIEKLKEAIRDTNKAVQSVQSSIGNLIVAIK-NH2	172
177	Ac-ARSDIEKLKEAIRDTNKAVQSVQSSIGNLIVAIKS-NH2	174
178	Ac-RSDIEKLKEAIRDTNKAVQSVQSSIGNLIVAIKSV-NH2	175
179	Ac-SDIEKLKEAIRDTNKAVQSVQSSIGNLIVAIKSVQ-NH2	176
180	Ac-DIEKLKEAIRDTNKAVQSVQSSIGNLIVAIKSVQD-NH2	177
181	Ac-IEKLKEAIRDTNKAVQSVQSSIGNLIVAIKSVQDY-NH2	178
182	Ac-EKLKEAIRDTNKAVQSVQSSIGNLIVAIKSVQDYV-NH2	179
183	Ac-KLKEAIRDTNKAVQSVQSSIGNLIVAIKSVQDYVN-NH2	180
184	Ac-LKEAIRDTNKAVQSVQSSIGNLIVAIKSVQDYVNK-NH2	181
185	Ac-KEAIRDTNKAVQSVQSSIGNLIVAIKSVQDYVNKE-NH2	182
186	Ac-EAIRDTNKAVQSVQSSIGNLIVAIKSVQDYVNKEI-NH2	183
187	Ac-AIRDTNKAVQSVQSSIGNLIVAIKSVQDYVNKEIV-NH2	184
188	Ac-IRDTNKAVQSVQSSIGNLIVAIKSVQDYVKKEIV-NH2	185
189	Ac-YTFNDITLNNSVALDFIDISIELNKAKSDLEESKE-NH2	186
190	Ac-TPNDITLNNSVALDPIDISIELNKAKSDLEESKEW-NH2	187
191	Ac-PNDITLNNSVALDPIDISIELNKAKSDLEESKEWI-NH2	188
192	Ac-NDITLNNSVALDPIDISIELNKAKSDLEESKEWIR-NH2	189
193	Ac-DITLNNSVALDPIDISIELNKAKSDLEESKEWIRR-NH2	190
194	Ac-ITLNNSVALDPIDISIELNKAKSDLEESKEWIRRS-NH2	191
195	Ac-TLNNSVALDPIDISIELNKAKSDLEESKEWIRRSN-NH2	192
196	Ac-LNNSVALDPIDISIELNKAKSDLEESKEWIRRSNQ-NH2	193
197	Ac-NNSVALDPIDISIELNKAKSDLEESKEWIRRSNQK-NH2	194
198	Ac-NSVALDPIDISIELNKAKSDLEESKEWIRRSNQKL-NH2	195
200	Ac-SVALDPIDISIELNKAKSDLEESKEWIRRSNQKLD-NH2	197
201	Ac-VALDPIDISIELNKAKSDLEESKEWIRRSNQKLDS-NH2	198
202	Ac-ALDPIDISIELNKAKSDLEESKEWIRRSNQKLDSI-NH2	199
203	Ac-LDPIDISIELNKAKSDLEESKEWIRRSNQKLDSIG-NH2	200
204	Ac-DPIDISIELNKAKSDLEESKEWIRRSNQKLDSIGN-NH2	201
205	Ac-PIDISIELNKAKSDLEESKEWIRRSNQKLDSIGNW-NH2	202
206	Ac-IDISIELNKAKSDLEESKEWIRRSNQKLDSIGNWH-NH2	203
207	Ac-DISIELNAAKSDLEESKEWIRRSNQKLDSIGNWHQ-NH2	204
208	Ac-ISIELNKAKSDLEESKEWIRRSNQKLDSIGNWHQS-NH2	205
209	Ac-SIELNKAKSDLEESKEWIRRSNQKLDSIGNWHQSS-NH2	206
210	Ac-IELNKAKSDLEESKEWIRRSNQKLDSIGNWHQSST-NH2	207
211	Ac-ELNKAKSDLEESKEWIRRSNQKLDSIGNWHQSSTT-NH2	208
212	Ac-ELRALRGELRALRGELRALRGELRALRGELRALRGK-NH2	209
213	Ac-YTSLIHSLIEESQNQQQKNEQELLELDKWASLWNWF-NH2	210
214	Ac-YTSLIHSLIEESQNQQEKNEQELLELNKWASLWNWF-NH2	211
215	Ac-YTSHHSLIEQSQNQQEKNEQELLELDKWASLWNWF-NH2	212
216	Ac-YTSLIHSLIQESQNQQEKNEQELLELDKWASLWNWF-NH2	213
217	Ac-YTSLIHSLIQQSQNQQQKNQQQLLQLNKWASLWNWF-NH2	214
218	Ac-EQELLELDKWASLWNWF-NH2	215
219	Ac-QELLELDKWASLWNWF-NH2	216
220	Ac-ELLELDKWASLWNWF-NH2	217
221	Ac-LELDKWASLWNWF-NH2	218
222	Ac-ELDKWASLWNWF-NH2	219
226	Ac-WASLWNWF-NH2	223
227	Ac-ASLWNWF-NH2	224
229	Ac-YTSLIHSLIEESQNQQEKNEQELLELDKWASLANAA-NH2	226
230	Ac-YTSLIHSLIEESQNQQEKNEQQLLELDKWASLWNWF-NH2	227
231	Ac-YTSLIQSLIEESQNQQEKNQQELLELDKWASLWNWF-NH2	228
234	Ac-EAAAREAAAREAAARLELDKWASLWNWF-NH2	231
236	Ac-PSLRDPISAEISIQALSYALGGDINKVLEKLGYSG-NH2	233
237	Ac-SLRDPISAEISIQALSYALGGDINKVLEKLGYSGG-NH2	234
238	Ac-LRDPISAEISIQALSYALGGDINKVLEKLGYSGGD-NH2	235
239	Ac-RDPISAEISIQALSYALGGDINKVLEKLGYSGGDL-NH2	236
240	Ac-DPISAEISIQALSYAIIGGDINKVLEKLGYSGGDLL-NH2	237
241	Ac-PISAEISIQALSYALGGDINKVLEKLGYSGGDLLG-NH2	238
242	Ac-ISAEISIQALSYALGGDINKVLEKLGYSGGDLLGI-NH2	239
243	Ac-SAEISIQALSYALGGDINKVLEKLGYSGGDLLGIL-NH2	240
244	Ac-AEISIQALSYALGGDINKVLEKLGYSGGDLLGILE-NH2	241
245	Ac-EISIQALSYALGGDINKVLEKLGYSGGDLLGILES-NH2	242
246	Ac-ISIQALSYALQGDINKVLEKLGYSGGDLLGILESR-NH2	243
247	Ac-SIQALSYALGGDINKVLEKLGYSGGDLLGILESRG-NH2	244
248	Ac-IQALSYALGGDINKVLEKLGYSGGDLLGILESRGI-NH2	245
249	Ac-QALSYALGGDINKVLEKLGYSGGDLLGILESRGIK-NH2	246
250	Ac-ALSYALGGDINKVLEKLGYSGGDLLGILESRGIKA-NH2	247
251	Ac-LSYALGGDINKVLEKLGYSGGDLLGILESRGIKAR-NH2	248
252	Ac-PDAVYLHRIDLGPPISLERLDVGTNLGNAIAKLED-NH2	249
253	Ac-DAVYLHRIDLGPPISLERLDVGTNLGNAIAKLEDA-NH2	250
254	Ac-AVYLHRIDLGPPISLERLDVGTNLGNAIAKLEDAK-NH2	251
255	Ac-VYLHRDLGPPISLERLDVGTNLGNAIAKLEDAKE-NH2	252
256	Ac-YLHRIDLGPPISLERLDVGTNLGNAIAKLEDAKEL-NH2	253
257	Ac-LHRIDLGPPISLERLDVGTNLGNAIAKLEDAKELL-NH2	254
258	Ac-HRIDLGPPISLERLDVGTNLGNAIAKLEDAKELLE-NH2	255
259	Ac-RIDLGPPISLERLDVGTNLGNAIAKLEDAKELLES-NH2	256
260	Ac-IDLGPPISLERLDVGTNLGNAIAKLEDAKELLESS-NH2	257
261	Ac-DLGPPISLERLDVGTNLGNAIAKLEDAKELLESSD-NH2	258
262	Ac-LGPPISLERLDVGTNLGNAIAKLEDAKELLESSDQ-NH2	259
263	Ac-GPPISLERLDVGTNLGNAIAKLEDAKELLESSDQI-NH2	260
264	Ac-PPISLERLDVGTNLGNAIAKLEDAKELLESSDQIL-NH2	261
265	Ac-PISLERLDVGTNLGNAIAKLEDAKELLESSDQILR-NH2	262
266	Ac-ISLERLDVGTNLGNAIAKLEDAKELLESSDQIRS-NH2	263
267	Ac-SLERLDVGTNLGNAIAKLEDAKELLESSDQILRSM-NH2	264
268	Ac-LERLDVGTNLGNAIAKLEDAKELLESSDQILRSMK-NH2	265
269	Ac-EWIRRSNQKLDSI-NH2	266
270	Ac-LELDKWASLANAF-NH2	267
271	Ac-LELDKWASLENFF-NH2	268
272	Ac-LELDKWASLANWF-NH2	269
273	Ac-LELDKWASLWNAF-NH2	270
274	Ac-ELGNVNNSISNALDKLEESNSKLDKVNVKLTSTSA-NH2	271
275	Ac-TELGNVNNSISNALDKLEESNSKLDKVNVKLTSTS-NH2	282
276	Ac-STELGNVNNSISNALDKLEESNSKLDKVNVKLTST-NH2	273
277	Ac-ISTBLGNVNNSISNALDKLEESNSKLDKVNVKLTS-NH2	274
278	Ac-DISTELGNVNNSISNALDKLEESNSKLDKVNVKLT-NH2	275
279	Ac-LDISTELGNVNNSISNALDKLEESNSKLDKVNVKL-NH2	276
280	Ac-NLDISTELGNVNNSISNALDKLEESNSKLDKVNVK-NH2	277
281	Ac-GNLDISTELGNVNNSISNALDKLEESNSKLDKVNV-NH2	278
282	Ac-TGNLDISTELGNVNNSISNALDKLEESNSKLDKVN-NH2	279
283	Ac-VTGNLDISTELGNVNNSISNALDKLEESNSKLDKV-NH2	280
284	Ac-IVTGNLDISTELGNVNNSISNALDKLEESNSKLDK-NH2	281
285	Ac-VIVTGNLDISTELGNVNNSISNALDKLEESNSKLD-NH2	282
286	Ac-QVIVTGNLDISTELGNVNNSISNALDKLEESNSKL-NH2	283
287	Ac-SQVIVTGNLDISTELGNVNNSISNALDKLEESNSK-NH2	284
288	Ac-DSQVIVTGNLDISTELGNVNNSISNALDKLEESNS-NH2	285
289	Ac-LDSQVIVTGNLDISTELGNVNNSISNALDKLEESN-NH2	286
290	Ac-ILDSQVIVTGNLDISTELGNVNNSISNALDKLEES-NH2	287
291	Ac-SILDSQVIVTGNLDISTELGNVNNSISNALDKLEE-NH2	288
292	Ac-ISILDSQVIVTGNLDISTELGNVNNSISNALDKLE-NH2	289
293	Ac-NISILDSQVIVTGNLDISTELGNVNNSISNALDKL-NH2	290
294	Ac-KNISILDSQVIVTGNLDISTELGNVNNSISNALDK-NH2	291
295	Ac-QKNISILDSQVIVTGNLDISTELGNVNNSISNALD-NH2	292
296	Ac-YQKNISILDSQVIVTGNLDISTELGNVNNSISNAL-NH2	293
297	Ac-TYQKNISILDSQVIVTGNLDISTELGNVNNSISNA-NH2	294
298	Ac-ATYQKNISILDSQVIVTGNLDISTELGNVNNSISN-NH2	295
299	Ac-DATYQKNISILDSQVTVTGNLDISTELGNVNNSIS-NH2	296
300	Ac-FDATYQKNISILDSQVIVTGNLDISTELGNVNNSI-NH2	297
301	Ac-EFDATYQKNISILDSQVIVTGNLDISTELGNVNNS-NH2	298
302	Ac-GEFDATYQKNISILDSQVIVTGNLDISTELGNVNN-NH2	299
303	Ac-SGEFDATYQKNISILDSQVIVTGNLDISTELGNVN-NH2	300
304	Ac-LSGEFDATYQKNISILDSQVIVTGNLDISTELGNV-NH2	301
305	Ac-RLSGEFDATYQKNISILDSQVIVTGNLDISTELGN-NH2	302
306	Ac-LRLSGEFDATYQKNISILDSQVIVTGNLDISTELG-NH2	303
307	Ac-TLRLSGEFDATYQKNISILDSQVIVTGNLDISTEL-NH2	304
308	Ac-ITLRLSGEFDATYQKNISILDSQVIVTGNLDISTE-NH2	305
309	Ac-GITLRLSGEFDATYQKNISILDSQVIVTGNLDIST-NH2	306
310	Ac-TATIEAVHEVTDGLSQLAVAVGKMQQFVNDQFNNT-NH2	307
311	Ac-ITATIEAVHEVTDGLSQLAVAVGKMQQFVNDQFNN-NH2	308
312	Ac-SITATIEAVHEVTDGLSQLAVAVGKMQQFVNDQFN-NH2	309
314	Ac-KESITATIEAVHEVTDGLSQLAVAVGKMQQFVNDQ-NH2	310
315	Ac-LKESITATIEAVHEVTDGLSQLAVAVGKMQQFVND-NH2	311
316	Ac-RLKESITATIEAVHEVTDGLSQLAVAVGKMQQFVN-NH2	312
317	Ac-LRLKESITATIEAVHEVTDGLSQLAVAVGKMQQFV-NH2	313
318	Ac-ILRLKESITATIEAVHEVTDGLSQLAVAVGKMQQF-NH2	314
319	Ac-NILRLKESITATIEAVHEVTDGLSQLAVAVGKMQQ-NH2	315
320	Ac-ANILRLKESITATIEAVHEVTDGLSQLAVAVGKMQ-NH2	316
321	Ac-AANILRLKESITATIEAVHEVTDGLSQLAVAVGKM-NH2	317
322	Ac-HKCDDECMNSVKNGTYDYPKYEEESKLNRNEIKGV-NH2	318
323	Ac-KCDDECMNSVKNGTYDYPKYEEESKLNRNEIKGVK-NH2	319
324	Ac-CDDECMNSVKNGTYDYPKYEEESKLNRNEIKGVKL-NH2	320
325	Ac-DDECMNSVKNGTYDYPKYEEESKLNRNEIKGVKLS-NH2	321
326	Ac-DECMNSVKNGTYDYPKYEEESKLNRNEIKGVKLSS-NH2	322
327	Ac-ECMNSVKNGTYDYPKYEEESKLNRNEIKGVKLSSM-NH2	323
328	Ac-CMNSVKNGTYDYPKYEEESKLNRNEIKGVKLSSMG-NH2	324
329	Ac-MNSVKNGTYDYPKYEEESKLNRNEIKGVKLSSMGV-NH2	325
330	Ac-NSVKNGTYDYPKYEEESKLNRNEIKGVKLSSMGVY-NH2	326
331	Ac-SVKNGTYDYPKYEEESKLNRNEIKGVKLSSMGVYQ-NH2	327
332	Ac-VKNGTYDYPKYEEESKLNRNEIKGVKLSSMGVYQI-NH2	328
333	Ac-KNGTYDYPKYEEESKLNRNEIKGVKLSSMGVYQIL-NH2	329
334	Ac-AFIRKSDELLHNV-NH2	330
335	Ac-VVLAGAALGVATAAQITAGIALHQSMLNSQAIDNL-NH2	331
336	Ac-VLAGAALGVATAAQITAGIALHQSMLNSQAIDNLR-NH2	332
337	Ac-LAGAALGVATAAQITAGIALHQSMLNSQAIDNLRA-NH2	333
338	Ac-AGAALGVATAAQITAGIALHQSMLNSQAIDNLRAS-NH2	334
339	Ac-GAALGVATAAQITAGIALHQSMLNSQAIDNLRASL-NH2	335
340	Ac-AALGVATAAQITAGIALHQSMLNSQAIDNLRASLE-NH2	336
341	Ac-ALGVATAAQITAGIALHQSMLNSQAIDNLRASLET-NH2	337
342	Ac-LGVATAAQITAGIALHQSMLNSQAIDNLRASLETT-NH2	338
343	Ac-GVATAAQITAGIALHQSMLNSQAIDNLRASLETTN-NH2	339
344	Ac-VATAAQITAGIALHQSMLNSQAIDNLRASLETTNQ-NH2	340
345	Ac-ATAAQITAGIALHQSMLNSQAIDNLRASLETTNQA-NH2	341
346	Ac-TAAQITAGIALHQSMLNSQAIDNLRASLETTNQAI-NH2	342
347	Ac-AAQITAGIALHQSMLNSQAIDNLRASLETTNQAIE-NH2	343
348	Ac-AQITAGIALHQSMLNSQAIDNLRASLETTNQAIEA-NH2	344
349	Ac-QITAGIALHQSMLNSQAIDNLRASLETTNQAIEAI-NH2	345
350	Ac-ITAGIALHQSMLNSQAIDNLRASLETTNQAIEAIR-NH2	346
351	Ac-TAGIALHQSMLNSQAIDNLRASLETTNQAIEAIRQ-NH2	347
352	Ac-AGIALHQSMLNSQAIDNLRASLETTNQAIEAIRQA-NH2	348
353	Ac-GIALHQSMLNSQAIDNLRASLETTNQAIEAIRQAG-NH2	349
354	Ac-IALHQSMLNSQAIDNLRASLETTNQAIEAIRQAGQ-NH2	350
355	Ac-ALHQSMLNSQAIDNLRASLETTNQAIEAIRQAGQE-NH2	351
356	Ac-LHQSMLNSQAIDNLRASLETTNQAIEAIRQAGQEM-NH2	352
357	Ac-HQSMLNSQAIDNLRASLETTNQAIEAIRQAGQEMI-NH2	353
358	Ac-QSMLNSQAIDNLRASLETTNQAIEAIRQAGQEMIL-NH2	354
359	Ac-SMLNSQAIDNLRASLETTNQAIEAIRQAGQEMILA-NH2	355
360	Ac-MLNSQAIDNLRASLETTNQAIEAIRQAGQEMILAV-NH2	356
361	Ac-LNSQAIDNLRASLETTNQAIEAIRQAGQEMILAVQ-NH2	357
362	Ac-NSQAIDNLRASLETTNQAIEAIRQAGQEMILAVQG-NH2	358
363	Ac-SQAIDNLRASLETTNQAIEAIRQAGQEMILAVQGV-NH2	359
364	Ac-QAIDNLRASLETTNQAIEAIRQAGQEMILAVQGVQ-NH2	360
365	Ac-AIDNLRASLETTNQAIEAIRQAGQEMILAVQGVQD-NH2	361
366	Ac-IDNLRASLETTNQAIEAIRQAGQEMILAVQGVQDY-NH2	362
367	Ac-DNLRASLETTNQAIEAIRQAGQEMILAVQGVQDYI-NH2	363
368	Ac-NLRASLETTNQAIEAIRQAGQEMILAVQGVQDYIN-NH2	364
369	Ac-LRASLETFNQAIEAIRQAGQEMILAVQGVQDYINN-NH2	365
370	Ac-RASLETTNQAIEAIRQAGQEMILAVQGVQDYINNE-NH2	366
371	Ac-YTSVITIELSNIKENKLNGTDAVKLIKQELDKYK-NH2	367
372	Ac-TSVITIELSNIKENKLNGTDAVKLIKQELDKYKN-NH2	368
373	Ac-SVITIELSNIKENKLNGTDAVKLIKQELDKYKNA-NH2	369
374	Ac-SNIKENKLNGTDAKVKLIKQELDKYKNAVTELQLL-NH2	370
375	Ac-KENKLNGTDAKVKLIKQELDKYKNAVTELQLLMQS-NH2	371
376	Ac-CLELDKWASLWNWFC-NH2	372
377	Ac-CLELDKWASLANWFC-NH2	373
378	Ac-CLELDKWASLFNFFC-NH2	374
379	Ac-YTSLIHSLIEESQNQQEKNEQELLELDKWASLFNFF-NH2	375
381	Ac-KMKQLEDKVEELLSKNYHLENELELDKWASLWNWF-NH2	376
382	Ac-KVEELLSKNYHLENELELDKWASLWNWF-NH2	377
383	Ac-RMKQLEDKVEELLSKLEWIRRSNQKLDSI-NH2	378
384	Ac-RMKQLEDkVEELLSKLAFIRKSDELLHNV-NH2	379
385	Ac-ELEALRGELRALRGELELDKWASLWNWF-NH2	380
386	Ac-LDPIDISIELNKAKSDLEESKEWIRRSNQKLDSI-NH2	381
387	Ac-CNEQLSDSFPVEFFQV-NH2	382
388	Ac-MAEDDPYLGRPEQMFHLDPSL-NH2	383
389	Ac-EDFSSIADMDFSALLSQISS-NH2	384
390	Ac-TWQEWERKVDFLEENITALLEEAQIQQEKNMYELQ-NH2	385
391	Ac-WQEWERKVDFLEENITALLEEAQIQQEKNMYELQK-NH2	386
392	Ac-QEWERKVDFLEENITALLEEAQIQQEKNMYELQKL-NH2	387
393	Ac-EWERKVDFLEENITALLEEAQIQQEKNMYELQKLN-NH2	388
394	Ac-WERKVDFLEENITALLEEAQIQQEKNMYELQKLNS-NH2	389
395	Ac-ERKVDFLEENITALLEEAQIQQEKNMYELQKLNSW-NH2	390
396	Ac-RKVDFLEENITALLEEAQIQQEKNMYELQKLNSWD-NH2	391
397	Ac-KVDFLEENITALLEEAQIQQEKNMYELQKLNSWDV-NH2	392
398	Ac-VDFLEENITALLEEAQIQQEKNMYELQKLNSWDVF-NH2	393
399	Ac-DFLEENITALLEEAQIQQEKNMYELQKLNSWDVFG-NH2	394
400	Ac-FLEENITALLEEAQIQQEKNMYELQKLNSWDVFGN-NH2	395
401	Ac-LEENITALLEEAQIQQEKNMYELQKLNSWDVFGNW-NH2	396
402	Ac-LEENITALLEEAQIQQEKNMYELQKLNSWDVFGNWF-NH2	397
403	Ac-NEQSEEKENELYWAKEQLLDLLFNIFNQTVGAWIMQ-NH2	398
405	Ac-QQQLLDVVKRQQELLRLTVWGTKNLQTRVTAIEKYLKD-NH2	400
406	Ac-QQLLDVVKRQQELLRLTVWGTKNLQTRVTAIEKYLKLQ-NH2	401
407	Ac-QQLLDVVKRQQELLRLTVWGPKNLQTRVTAIEKYLKLQ-NH2	402
408	Ac-DERKQDKVLVVQQTGTLQtTLIQLEKTAKLQWVRLNRY-NH2	403
409	Ac-QQQLLDVVKRQQELLRLTVWGTKNLQTRVTAIEKY-NH2	404
410	Ac-QQLLDVVKRQQELLRLTVWGTKNLQTRVTAIEKYL-NH2	405
411	Ac-QLLDVVKRQQELLRLTVWGTKNLQTRVTAIEKYLK-NH2	406
412	Ac-LLDVVKRQQELLRLTVWGTKNLQTRVTAIEKYLKL-NH2	407
413	Ac-LDVVKRQQELLRLTVWGTKNLQTRVTAIEKYLKLQ-NH2	408
414	Ac-DVKKRQQELLRLTVWGTKNLQTRVTAIEKYLKLQA-NH2	409
415	Ac-VVKRQQELLRLTVWGTKNLQTRVTAIEKYLKLQAQ-NH2	410
416	Ac-VKRQQELLRLTVWGTKNLQTRVTAIEKYLKLQAQL-NH2	411
417	Ac-KRQQELLRLTVWGTKNLQTRVTAIEKYLKDQAQLN-NH2	412
418	Ac-RQQELLRLTVWGTKNLQTRVTAIEKYLKDQAQLNA-NH2	413
419	Ac-QQELLRLTVWGTKNLQTRVTAIEKYLKDQAQLNAW-NH2	414
420	Ac-QELLRLTVWGTKNLQTRVTAIEKYLKDQAQLNAWG-NH2	415
421	Ac-ELLRLTVWGTKNLQTRVTAIEKYLKDQAQLNAWGC-NH2	416
422	Ac-NNLLRAIEAQQHLLQLTVWGPKQLQARILAVERYLKDQ-NH2	417
423	Ac-SELEIKRYKNRVASRKCRAKFKQLLQHYREVAAAK-NH2	418
424	Ac-ELEIKRYKNRVASRKCRAKFKQLLQHYREVAAAKS-NH2	419
425	Ac-LEIKRYNNRVASRKCRAKFKQLLQHYREVAAAKSS-NH2	420
426	Ac-EIKRYKNRVASRKCRAKFKQLLQHYREVAAAKSSE-NH2	421
427	Ac-IKRYKNRVASRKCRAKFKQLLQHYREVAAAKSSEN-NH2	422
428	Ac-KRYKNRVASRKCRAKFKQLLQHYREVAAAKSSEND-NH2	423
429	Ac-RYKNRVASRKCRAKFKQLLQHYREVAAAKSSENDR-NH2	424
430	Ac-YKNRVASRKCRAKFKQLLQHYREVAAAKSSENDRL-NH2	425
431	Ac-KNRVASRKCRAKFKQLLQHYREVAAAKSSENDRLR-NH2	426
432	Ac-NRVASRKCRAKFKQLLQHYREVAAAKSSENDRLRL-NH2	427
433	Ac-RVASRKCRAKFKQLLQHYREVAAAKSSENDRLRLL-NH2	428
434	Ac-VASRKCRAKFKQLLQHYREVAAAKSSENDRLRLLL-NH2	429
435	Ac-ASRKCRAKFKQLLQHYREVAAAKSSENDRLRLLLK-NH2	430
436	Ac-SRKCRAKFKQLLQHYREVAAAKSSENDRLRLLLKQ-NH2	431
437	Ac-RKCRAKFKQLLQHYREVAAAKSSENDRLRLLLKQM-NH2	432
438	Ac-KCRAKFKQLLQHYREVAAAKSSENDRLRLLLKQMC-NH2	433
439	Ac-CRAKFKQLLQHYREVAAAKSSENDRLRLLLKQMCP-NH2	434
440	Ac-RAKFKQLLQHYREVAAAKSSENDRLRLLLKQMCPS-NH2	435
441	Ac-AKFKQLLQHYREVAAAKSSENDRLRLLLKQMCPSL-NH2	436
442	Ac-KFKQLLQHYREVAAAKSSENDRLRLLLKQMCPSLD-NH2	437
443	Ac-FKQLLQHYREVAAAKSSENDRLRLLLKQMCPSLDV-NH2	438
444	Ac-KQLLQHYREVAAAKSSENDRLRLLLKQMCPSLDVD-NH2	439
445	Ac-QLLQHYREVAAAKSSENDRLRLLLKQMCPSLDVDS-NH2	440
446	Ac-LLQHYREVAAAKSSENDRLRLLLKQMCPSLDVDSI-NH2	441
447	Ac-LQHYREVAAAKSSENDRLRLLLKQMCPSLDVDSII-NH2	442
448	Ac-QHYREVAAAKSSENDRLRLLLKQMCPSLDVDSIIP-NH2	443
449	Ac-HYREVAAAKSSENDRLRLLLKQMCPSLDVDSIIPR-NH2	444
450	Ac-YREVAAAKSSENDRLRLLLKQMCPSLDVDSIIPRT-NH2	445
451	Ac-REVAAAKSSENDRLRLLLKQMCPSLDVDSIIPRTP-NH2	446
452	Ac-EVAAAKSSENDRLRLLLKQMCPSLDVDSIIPRTPD-NH2	447
453	Ac-VAAAKSSENDRLRLLLKQMCPSLDVDSIIPRTPDV-NH2	448
454	Ac-AAAKSSENDRLRLLLKQMCPSLDVDSIIPRTPDVL-NH2	449
455	Ac-AAKSSENDRLRLLLKQMCPSLDVDSIIPRTPDVLH-NH2	450
456	Ac-AKSSENDRLRLLLKQMCPSLDVDSIIPRTPDVLHE-NH2	451
457	Ac-KSSENDRLRLLLKQMCPSLDVDSIIPRTPDVLHED-NH2	452
458	Ac-SSENDRLRLLLKQMCPSLDVDSIIPRTPDVLHEDL-NH2	453
459	Ac-SENDRLRLLLKQMCPSLDVDSIIPRTPDVLHEDLL-NH2	454
460	Ac-ENDRLRLLLKQMCPSLDVDSIIPRTPDVLHEDLLN-NH2	455
461	Ac-NDRLRLLLKQMCPSLDVDSIIPRTPDVLHEDLLNF-NH2	456
534	Ac-PGYRWMCLRRFIIFLFILLLCLIFLLVLLDYQGML-NH2	458
535	Ac-GYRWMCLRRFIIFLFILLLCLIFLLVLLDYQGMLP-NH2	459
536	Ac-YRWMCLRRFIIFLFILLLCLIFLLVLLDYQGMLPV-NH2	460
537	Ac-RWMCLRRFIIFLFILLLCLIFLLVLLDYQGMLPVC-NH2	461
538	Ac-WMCLRRFIIFLFILLLCLIFLLVLLDYQGMLPVCP-NH2	462
539	Ac-MCLRRFIIFLFILLLCLIFLLVLLDYQGMLPVCPL-NH2	463
540	Ac-CLRRFIIFLFILLLCLIFLLVLLDYQGMLPVCPLI-NH2	464
541	Ac-LRRFIIFLFILLLCLIFLLVLLDYQGMLPVCPLIP-NH2	465
542	Ac-RRFIIFLFILLLCLIFLLVLLDYQGMLPVCPLIPG-NH2	466
543	Ac-RFIIFLFILLLCLIFLLVLLDYQGMLPVCPLIPGS-NH2	467
544	Ac-FIIFLFILLLCLIFLLVLLDYQGMLPVCPLIPGSS-NH2	468
545	Ac-HFLFILLLCLIFLLVLLDYQGMLPVCPLIPGSST-NH2	469
546	Ac-IFLFILLLCLIFLLVLLDYQGMLPVCPLIPGSSTT-NH2	470
547	Ac-FLFILLLCLIFLLVLLDYQGMLPVCPLIPGSSTTS-NH2	471
548	Ac-LFILLLCLIFLLVLLDYQGMLPVCPLIPGSSTTST-NH2	472
549	Ac-FILLLCLIFLLVLLDYQGMLPVCPLIPGSSTTSTG-NH2	473
550	Ac-ILLLCLIFLLVLLDYQGMLPVCPLIPGSSTTSTGP-NH2	474
551	Ac-LLLCLIFLLVLLDYQGMLPVCPLIPGSSTTSTGPC-NH2	475
552	Ac-LLCLIFLLVLLDYQGMLPVCPLIPGSSTTSTGPCR-NH2	476
553	Ac-LCLIFLLVLLDYQGMLPVCPLIPGSSTTSTGPCRT-NH2	477
554	Ac-CLIFLLVLLDYQGMLPVCPLIPGSSTTSTGPCRTC-NH2	478
555	Ac-LIFLLVLLDYQGMLPVCPLIPGSSTTSTGPCRTCM-NH2	479
556	Ac-IFLLVLLDYQGMLPVCPLIPGSSTTSTGPCRTCMT-NH2	480
557	Ac-FLLVLLDYQGMLPVCPLIPGSSTTSTGPCRTCMTT-NH2	481
558	Ac-PPLVLQAGFFLLTMLTIPQSLDSWWTSLNFLGGT-NH2	482
559	Ac-LLVLQAGFFLLTRILTIPQSLDSWWTSLNFLGGTT-NH2	483
560	Ac-LVLQAGFFLLTRILTIPQSLDSWWTSLNFLGGTTV-NH2	484
561	Ac-VLQAGFFLLTMLTIPQSLDSWWTSLNFLGGTTVC-NH2	485
562	Ac-LQAGFFLLTMLTIPQSLDSWWTSLNFLGGTTVCL-NH2	486
563	Ac-QAGFFLLTRILTIPQSLDSWWTSLNFLGGTTVCLG-NH2	487
564	Ac-AGFFLLTMLTIPQSLDSWWTSLNFLGGTTVCLGQ-NH2	488
565	Ac-GFFLLTRILTIPQSLDSWWTSLNFLGGTTVCLGQN-NH2	489
566	Ac-FFLLTRILTIPQSLDSWWTSLNFLGGTTVCLGQNS-NH2	490
567	Ac-FLLTMLTIPQSLDSWWTSLNFLGGTTVCLGQNSQ-NH2	491
568	Ac-LLTRILTIPQSLDSWWTSLNFLGGTTVCLGQNSQS-NH2	492
569	Ac-LTMLTIPQSLDSWWTSLNFLGGTTVCLGQNSQSP-NH2	493
570	Ac-FWNWLSAWKDLELKSLLEEVKDELQKMR-NH2	494
571	Ac-NNLLRAIEAQQHLLQLTVW-NH2	495
572	Ac-CGGNNLLRAIEAQQHLLQLTVWGIKQLQAMLAVERYLKDQ-NH2	496
573	Ac-YTSLIHSLIEESQNQQEKNEQELLELDKWASLWNWF-NH2	497
574	C13H27CO-YTSLIHSLIEESQNQQEKNEQELLELDKWASLWNWF-NH2	498
575	Ac-AVSKGYLSALRTGWYTSVITIELSNIKENKLNGTDA-NH2	499
576	Ac-SISNIETVIEFQQKRRRLLEITREFSVNAGVTTPVS-NH2	500
577	Ac-DQQIKQYRRLLDRLIIPLYDGLRQKDVWSNQESN-NH2	501
578	Ac-YSELTNIFGDMGSLQEKGIKLQGIASLYRTNITEI-NH2	502
579	Ac-TSITLQVRLPLLTRLLNTQIYRVDSISYNIQNREWY-NH2	503
580	Ac-VEIAEYRRLLRTVLEPIRDALNAMTQNIRPVQSVA-NH2	504
581	Ac-SYFIVLSIAYPTLSEIKGVIVHRLEGVSYNIGSQEW-NH2	505
582	Ac-LKEAIRDTKKAVQSVQSSIGNLIVAIKS-NH2	506
583	NNLLRAIEAQQHLLQLTVWGIKQLQARILAVERYLKDQ-NH2	507
583	NNLLRAIEAQQHLLQLTVWGIKQLQARILAVERYLKDQ-NH2	507
584	QKQEPIDKELYPLTSL	508
585	YPKFVKQNTLKLAT	509
586	QYIKANQKFIGITE	510
587	NGQIGNDPNRDILY	511
588	AC-RPDVY-OH	512
589	CLELDKWASLWWWFC-(cyclic)	513
590	CLELDKWASLANWFC-(cyclic)	514
591	CLELDKWASLANFFC-(cyclic)	515
594	Ac-NNLLRAIEAQQQHLLQLTVWGIKQLQARILAVERYLKDQ-NH2	516
595	Ac-CGGYTSLIHSLIEESQNQQEKNEQELLELDKWASLWNNWF-NH2	517
596	Ac-PLLVLQAGFFLLTRILTIPQSLDSWWTSLNFLGGT-NH2	518
597	Ac-LLVLQAGFFLLTRILTIPQSLDSWWTSLNFLGGTT-NH2	519
598	Ac-LVLQAGFFLLTRILTIPQStDSWWTSLNFLGGTTV-NH2	520
599	Ac-VLQAGFFLLTRILTIPQSLDSWWTSLNFLGGTTVC-NH2	521
600	Ac-LQAGFFLLTRILTIPQSLDSWWTSLNFLGGTTVCL-NH2	522
601	Ac-QAGFFLLTRILTIPQSLDSWWTSLNFLGGTTVCLG-NH2	523
602	Ac-AGFFLLTRILTIPQSLDSWWTSLNFLGGTTVCLGQ-NH2	524
603	Ac-GFFLLTRILTIPQSLDSWWTSLNFLGGTTVCLGQN-NH2	525
604	Ac-FFLLTRILTIPQSLDSWWTSLNFLGGTTVCLGQNS-NH2	526
605	Ac-FLLTRILTIPQSLDSWWTSLNFLGGTTVCLGQNSQ-NH2	527
606	Ac-LLTRILTIPQSLDSWWTSLNFLGGTTVCLGQNSQS-NH2	528
607	Ac-LTRILTIPQSLDSWWTSLNFLGGTTVCLGQNSQSP-NH2	529
608	Ac-LELDKWASLWNWA-NH2	530
609	Ac-LELDKWASAWNWF-NH2	531
610	Ac-LELDKAASLWNWF-NH2	532
611	Ac-LKLDKWASLWNWF-NH2	533
612	Ac-LELKKWASLWNWF-NH2	534
613	Ac-DELLHNVNAGKST-NH2	535
614	Ac-KSDELLHNVNAGKST-NH2	536
615	Ac-IRKSDELLHNVNAGKST-NH2	537
616	Ac-AFIRKSDELLHNVNAGKST-NH2	538
617	Ac-FDASISQVNEKINQSLAFI-NH2	539
618	Ac-YAADKESTQKAFDGITNKVNSVIEKMNTQFEAVGKE-NH2	540
619	Ac-SVIEKMNTQFEAVGKEFGNLERRLENLNKRMEDGFL-NH2	541
620	Ac-VWTYNAELLVLMENERTLDFHDSNNKNLYDKVRMQL-NH2	542
621	Ac-EWDREINNYTSLIHSLIEESQNQQEKNEQEGGC-NH2	543
622	Ac-INNYTSLIHSLIEESQNQQEKNEQELLELDKWASL-NH2	544
623	Ac-INNYTSLIHSLIEESQNQQEKNEQELLE-NH2	545
624	Ac-WMEWDREINNYTSLIHSLIEESQNQQEKNEQELLE-NH2	546
625	Ac-MTWMEWDREINNYTSLIHSLIEESQNQQEKNEQELLELDKWASLWNWF-NH2	547
626	Ac-IDISIELNKAKSDLEESKEWIKKSNQKLDSIGNWH-NH2	548
627	Ac-NQQEKNEQELLELDKWASLWNWFNITNWLWYIKIFI-NH2	549
627	Ac-NQQEKNEQELLELDKWASLWNWFNITNWLWYIKIFI-NH2	549
628	Ac-QNQQEKNEQELLELDKWASLWNWFNITNWLWYIKIF-NH2	550
629	Ac-SQNQQEKNBQELLELDKWASLWWWFMTNWLWYIKI-NH2	551
630	Ac-ESQNQQEKNEQELLELDKWASLWNWFNITNWLWYIK-NH2	552
631	Ac-EESQNQQEKNEQELLELDKWASLWNWFNITNWLWYI-NH2	553
632	Ac-IEESQNQQEKNEQELLELDKWASLWNWFhTNWLWY-NH2	554
633	Ac-LIEESQNQQEKNEQELLELDKWASLWNWFMTNWLW-NH2	555
634	Ac-SLIEESQNQQEKNEQELLELDKWASLWNWFNITNWL-NH2	556
635	Ac-HSLIEESQNQQEKNEQELLELDKWASLWNWFNITNW-NH2	557
636	Ac-IHSLIEESQNQQEKNEQELLELDKWASLWNWFNITN-NH2	558
637	Ac-LIHSLIEESQNQQEKNEQELLELDKWASLWNWFNIT-NH2	559
638	Ac-SLIHSLIEESQNQQEKNEQELLELDKWASLWNWFNI-NH2	560
639	Ac-TSLIHSLIEESQNQQEKNEQELLELDKWASLWNWFN-NH2	561
640	Ac-NYTSLIHSLIEESQNQQEKNEQELLELDKWASLWNW-NH2	562
641	Ac-NNYTSLIHSLIEESQNQQEKNEQELLELDKWASLWN-NH2	563
642	Ac-INNYTSLIHSLIEESQNQQEKNEQELLELDKWASLW-NH2	564
643	Ac-EINNYTSLIHSLIEESQNQQEKNEQELLELDKWASL-NH2	565
644	Ac-REINNYTSLIHSLIEESQNQQEKNEQELLELDKWAS-NH2	566
645	Ac-DREINNYTSLIHSLIEESQNQQEKNEQELLELDKWA-NH2	567
646	Ac-WDKEINNYTSLIHSLIEESQNQQEKNEQELLELDKW-NH2	568
647	Ac-EWDREINNYTSLIHSLIEESQNQQEKNEQELLELDK-NH2	569
648	Ac-MEWDREINNYTSLIHSLIEESQNQQEKNEQELLELD-NH	570
649	Ac-WMEWDREINNYTSLIHSLIEESQNQQEKNEQELLEL-NH2	572
650	Ac-TWMEWDREINNYTSLIHSLIEESQNQQEKNEQELLE-NH2	573
651	Ac-MTWMEWDREINNYTSLIHSLIEESQNQQEKNEQELL-NH2	574
652	Ac-NMTWMEWDREINNYTSLIHSLIEESQNQQEKNEQEL-NH2	575
653	Ac-NNMTWMEWDREINNYTSLIHSLIEESQNQQEKNEQE-NH2	576
654	Ac-WNNMTWMEWDREINNYTSLIHSLIEESQNQQEKNEQ-NH2	577
655	Ac-IWNNMTWMEWDREINNYTSLIHSLIEESQNQQEKNE-NH2	578
656	Ac-QIWNNMTWMEWDREINNYTSLIHSLIEESQNQQEKN-NH2	579
657	Ac-EQIWNNMTWMEWDREINNYTSLIHSLIEESQNQQEK-NH2	580
658	Ac-LEQIWNNMTWMEWDREINNYTSLIHSLIEESQNQQE-NH2	581
659	Ac-SLEQIWNNMTWMEWDREINNYTSLIHSLIEESQNQQ-NH2	582
660	Ac-KSLEQIWNNMTWMEWDREINNYTSLIHSLIEESQNQ-NH2	583
661	Ac-NKSLEQIWNNMTWMEWDREINNYTSLIHSLIEESQN-NH2	584
662	Ac-SLAFIRKSDELLHNVNAGKST-NH2	585
663	Ac-FDASISQVNEKINQSLAFIRK-NH2	586
664	Ac-YTSLIHSLIEESQQQQEKQEQELLELDKWASLWNWF-NH2	587
665	Ac-FDASISQVNEKINQSLAFIRKSDELLHNVNAGK-NH2	588
666	Ac-FDASISQVNEKINQSLAFIRKSDELLHNVNA-NH2	589
667	Ac-FDASISQVNEKINQSLAFIRKSDELLHNV-NH2	590
668	Ac-FDASISQVNEKINQSLAFIRKSDELLH-NH2	591
669	Ac-FDASISQVNEKINQSLAFIRKSDEL-NH2	592
670	Ac-FDASISQVNEKINQSLAFIRKSD-NH2	593
671	Ac-ASISQVNEKINQSLAFIRKSDELLHNVNAGKST-NH2	594
672	Ac-ISQVNEKINQSLAFIRKSDELLHNVNAGKST-NH2	595
673	Ac-QVNEKINQSLAFIRKSDELLHNVNAGKST-NH2	596
674	Ac-NEKINQSLAFIRKSDELLHNVNAGKST-NH2	597
675	Ac-KINQSLAFIRKSDELLHNVNAGKST-NH2	598
676	Ac-NQSLAFIRKSDELLHNVNAGKST-NH2	599
677	Ac-FWNWLSAWKDLELYPGSLELDKWASLWNWF-NH2	600
678	Ac-CGGNNLLRAIEAQQHLLQLTVWGIKQLQARILAVERYLKDQ-NH2	601
679	Ac-CGGYTSLIHSLIEESQNQQEKNEQELLELDKWASLWNWF-NH2	602
680	YTSLIHSLIEESQNQQEKNEQELLELDKWASLWNWF	603
681	NNLLRAIEAQQHLLQLTVWGIKQLQARILAVERYLKDQ	604
682	Ac-EKNMYELQKLNSWDVFTNWLDFTSWVRYIQYIQYGV-NH2	605
683	Ac-QEKNMYELQKLNSWDVFTNWLDFTSWVRYIQYIQYG-NH2	606
684	Ac-QQEKNMYELQKLNSWDVFTNWLDFTSWVRYIQYIQY-NH2	607
685	Ac-IQQEKNMYELQKLNSWDVFTNWLDFTSWVRYIQYIQ-NH2	608
686	Ac-QIQQEKNMYELQKLNSWDVFTNWLDFTSWVRYIQYI-NH2	609
687	Ac-AQIQQEKNMYELQKLNSWDVFTNWLDFTSWVRYIQY-NH2	610
688	Ac-QAQIQQEKNMYELQKLNSWDVFTNWLDFTSWVRYIQ-NH2	611
689	Ac-EQAQIQQEKNMYELQKLNSWDVFTNWLDFTSWVRYI-NH2	612
690	Ac-LEQAQIQQEKNMYELQKLNSWDVFTNWLDFTSWVRY-NH2	613
691	Ac-SLEQAQIQQEKNMYELQKLNSWDVFTNWLDFTSWVR-NH2	614
692	Ac-QSLEQAQIQQEKNMYELQKLNSWDVFTNWLDFTSWV-NH2	615
693	Ac-SQSLEQAQIQQEKNMYELQKLNSWDVFTNWLDFTSW-NH2	616
694	Ac-ISQSLEQAQIQQEKNMYELQKLNSWDVFTNWLDFTS-NH2	617
695	Ac-NISQSLEQAQIQQEKNMYELQKLNSWDVFTNWLDFT-NH2	618
696	Ac-ANISQSLEQAQIQQEKNMYELQKLNSWDVFTNWLDF-NH2	619
697	Ac-EAMSQSLEQAQIQQEKNMYELQKLNSWDVFTMWLD-NH2	620
699	Ac-YLEAMSQSLEQAQIQQEKNMYELQKLNSWDVFTNW-NH2	621
700	Ac-YTSLIHSLIEESQNQQEKNEQEL-NH2	622
701	Ac-YTSLIHSLIEESQNLQEKNEQELLELDKWASLWNWF-NH2	623
702	Ac-YTSLIHSLIEESQNQQEKLEQELLELDKWASLWNWF-NH2	624
703	Ac-YTSLIHSLIEESQNQQEKNEQELLEFDKWASLWNWF-NH2	625
704	Ac-YTSLIHSLIEESQNQQEKNEQELLELDKPASLWNWF-NH2	626
705	Ac-YTSLIHSLIEESQNQQEKNEQELLELDKWASPWNWF-NH2	627
706	Ac-YTSLIHSLIEESQNQQEKNEQELLELDKWASLWNSF-NH2	628
707	Biotin NH(CH2)4CO-YTSLIHSLIEESQNQQEKNEQELLELDKWASLWNWF-NH2	629
708	Biotin NH(CH2)6CO-YTSLIHSLIEESQNQQEKNEQELLELDKWASLWNWF-NH2	630
709	FMOC-YTSLIHSLIEESQNQQEKNEQELLELDKWASLWNWF	92
710	FMOC-NNLLRAIEAQQHLLQLTVWGIKQLQARILAVERYLKDQ	16
711	Ac-EWDREINNYTSLIHSLIEESQNQQEKNEQE-NH2	634
712	Ac-LIEESQNQQEKNEQELLELDKWASLWNWF-NH2	635
713	Ac-FWNWLSAWKDLELGGPGSGPGGLELDKWASLWNWF-NH2	636
714	Ac-LIHSLIEESQNQQEKNEQELLELDKWASL-NH2	637
715	Ac-TSLIHSLIEESQNQQEKNEQELLELDKWASLWNWF-NH2	638
716	Ac-LIHSLIEESQNQQEKNEQELLELDKWASLWNWF-NH2	639
718	FMOC-GGGGGYTSLIHSLIEESQNQQEKNEQELLELDKWASLWNWF-NH2	640
719	Ac-HSLIEESQNQQEKNEQELLELDKWASLWNWF-NH2	641
720	Ac-YTSLIYSLIEESQNQQEKNEQELLELDKWASLWNWF-NH2	642
721	Ac-YTSLIHSLIEKSQNQQEKNEQELLELDKWASLWNWF-NH2	643
722	Ac-YTSLIHSSIEESQNQQEKNEQELLELDKWASLWNWF-NH2	644
723	Ac-LEANISQLLEQAQIQQEKNMYELQKLNSWDVFTNWL-NH2	645
724	Ac-SLEECDSELEIKRYKNRVASRKCRAKFKQLLQHYR-NH2	646
725	Ac-LEECDSELEIKRYKNRVASRKCRAKFKQLLQHYRE-NH2	647
726	Ac-EECDSELEIKRYKNRVASRKCRAKFKQLLQHYREV-NH2	648
727	Ac-ECDSELEIKRYKNRVASRKCRAKFKQLLQHYREVA-NH2	649
728	Ac-CDSELEIKRYKNRVASRKCRAKFKQLLQHYREVAA-NH2	650
729	Ac-DSELEIKRYKNRVASRKCRAKFKQLLQHYREVAAA-NH2	651
730	Desaminotyrosine-FDASISQVNEKINQSLAFIRKSDELLHNVNAGKST-NH2	652
731	WASLWNW-NH2	653
732	Ac-EAQQHLLQLTVWGIKQLQARILAVERYLKDQQLGIWG-NH2	654
733	Ac-IEAQQHLLQLTVWGIKQLQARILAVERYLKDQQLLGIW-NH2	655
734	Ac-AIEAQQHLLQLTVWGIKQLQARILAVERYLKDQQLLGI-NH2	656
735	Ac-RAIEAQQHLLQLTVWGIKQLQARILAVERYLKDQQLLG-NH2	657
736	Ac-LRAIEAQQHLLQLTVWGIKQLQARILAVERYLKDQQLL-NH2	658
737	Ac-LLRAIEAQQHLLQLTVWGIKQLQARILAVERYLKDQQL-NH2	659
738	Ac-NLLRAIEAQQHLLQLTVWGIKQLQARILAVERYLKDQQ-NH2	660
739	Ac-QNNLLRAIEAQQHLLQLTVWGIKQLQARILAVERYLKD-NH2	661
740	Ac-QQNNLLRAIEAQQHLLQLTVWGIKQLQARILAVERYLK-NH2	662
741	Ac-QQQNNLLRAIEAQQHLLQLTVWGIKQLQARILAVERYL-NH2	663
742	Ac-VQQQNNLLRAIEAQQHLLQLTVWGIKQLQARILAVERY-NH2	664
743	Ac-IVQQQNNLLRAIEAQQHLLQLTVWGIKQLQARILAVER-NH2	665
744	Ac-GIVQQQNNLLRAIEAQQHLLQLTVWGIKQLQARILAVE-NH2	666
745	Ac-SGIVQQQNNLLRAIEAQQHLLQLTVWGIKQLQARILAV-NH2	667
758	Ac-RSMTLTVQARQLLSGIVQQQNNLLRAIEAQQHLLQLTV-NH2	668
760	Ac-GARSMTLTVQARQLLSGIVQQQNNLLRAIEAQQHLLQL-NH2	669
764	Ac-GSTMGARSMTLTVQARQLLSGIVQQQNNLLRAIEAQQH-NH2	670
765	Ac-GSTMGARSMTLTVQARQLLSGIVQQQNNLLRAIEAQQH-NH2	671
766	Ac-EGSTMGARSMTLTVQARQLLSGIVQQQNNLLRAIEAQQ-NH2	672
767	Ac-RAKFKQLLQHYREVAAAKSSENDRLRLL-NH2	673
768	Ac-AKFKQLLQHYREVAAAKSSENDRLRLLL-NH2	674
769	Ac-KFKQLLQHYREVAAAKSSENDRLRLLLK-NH2	675
770	Ac-FKQLLQHYREVAAAKSSENDRLRLLLKQ-NH2	676
771	Ac-RAKFKQELQHYREVAAAKSSENDRLRLLLKQMCPS-NH2	677
772	DKWASLWNWF-NH2	678
773	Biotin-FDASISQVNEKINQSLAFIRKSDELLHNVNAGKST-NH2	679
774	Ac-YDASISQVNEKINQSLAFIRKSDELLHNVNAGKST-NH2	680
775	Ac-YDASISQVNEKINQSLAYIRKSDELLHNVNAGKST-NH2	681
776	Ac-FDASISQVNEKINQSLAYIRKSDELLHNVNAGKST-NH2	682
777	Ac-FDASISQVQEKIQQSLAFIRKSDELLHQVQAGKST-NH2	683
778	Ac-FDASISQVNEKINQALAFIRKADELLHNVNAGKST-NH2	684
779	Ac-FDASISQVNEKINQALAFIRKSDELLHNVNAGKST-NH2	685
780	Ac-FDASISQVNEKINQSLAFIRKADELLHNVNAGKST-NH2	686
781	Ac-YDASISQVQEEIQQALAFIRKADELLEQVQAGKST-NH2	687
782	Ac-FDASISQVNEKINQSLAFIRKSDELLENVNAGKST-NH2	688
783	Ac-FDASISQVNEEINQSLAFIRKSDELLHNVNAGKST-NH2	689
784	Ac-VFPSDEFDASISQVNEKINQSLAFIRKSDELLENV-NH2	690
785	Ac-VFPSDEFDASISQVNEEINQSLAFIRKSDELLENV-NH2	691
786	Ac-VYPSDEYDASISQVNEEINQALAYIRKADELLENV-NH2	692
787	Ac-VFPSDEFDASISQVNEEINQSLAFIRKSDELLHNV-NH2	693
788	Ac-SNKSLEQIWNNMTWMEWDREINNYTSLIHSLIEESQ-NH2	694
789	Ac-WSNKSLEQIWNNMTWMEWDREINNYTSLIHSLIEES-NH2	695
790	Ac-SWSNKSLEQIWNNMTWMEWDREINNYTSLIHSLIEE-NH2	696
791	Ac-ASWSNKSLEQIWNNMTWMEWDREINNYTSLIHSLIE-NH2	697
792	Ac-NASWSNKSLEQIWNNMTWMEWDREINNYTSLIHSLI-NH2	698
793	Ac-WNASWSNKSLEQIWNNMTWMEWDREINNYTSLIHSL-NH2	699
793	Ac-WNASWSNKSLEQIWNNMTWMEWDREINNYTSLIHSL-NH2	699
794	Ac-PWNASWSNKSLEQIWNNMTWMEWDREINNYTSLIHS-NH2	700
795	Ac-VPWNASWSNKSLEQIWNNMTWMEWDREINNYTSLIH-NH2	701
796	Ac-AVPWNASWSNKSLEQIWNNMTWMEWDREINNYTSLI-NH2	702
797	Ac-TAVPWNASWSNKSLEQIWNNMTWMEWDREINNYTSL-NH2	703
798	Ac-TTAVPWNASWSNKSLEQIWNNMTWMEWDREINNYTS-NH2	704
800	Ac-AAASDEFDASISQVNEKINQSLAFIRKSDELLHNV-NH2	705
801	Ac-VFPAAAFDASISQVNEKINQSLAFIRKSDELLHNV-NH2	706
802	Ac-VFPSDEAAASISQVNEKINQSLAFIRKSDELLHNV-NH2	707
803	Ac-VFPSDEFDAAAAQVNEKINQSLAFIRKSDELLHNV-NH2	708
804	Ac-VFPSDEFDASISAAAEKINQSLAFIRKSDBLLHNV-NH2	709
805	Ac-VFPSDEFDASISQVNAAANQSLAFIRKSDELLHNV-NH2	711
806	Ac-VFPSDEFDASISQVNEKIAAALAFIRKSDELLHNV-NH2	712
807	Ac-VFPSDEFDASISQVNEKINQSAAAIRKSDELLHNV-NH2	713
808	Ac-VFPSDEFDASISQVNEKINQSLAFAAASDELLHNV-NH2	714
809	Ac-VFPSDEFDASISQVNEKINQSLAFIRKAAALLHNV-NH2	715
810	Ac-VFPSDEFDASISQVNEKINQSLAFIRKSDEAAANV-NH2	716
811	Ac-VFPSDEFDASISQVNEKINQSLAFIRKSDELLAAA-NH2	717
812	Ac-VYPSDEFDASISQVNEKINQSLAFIRKSDELLHNV-NH2	718
813	Ac-AAAAIHSLIEESQNQQEKNEQELLELDKWASLWNWF-NH2	719
814	Ac-YTSLIHSLIEESQQQQEKNEQELLELDKWASLWNWF-NH2	720
815	Ac-YTSLIHSLIEESQNQQEKQEQELLELDKWASLWNWF-NH2	721
816	Ac-QIWNNMTWMEWDREINNYTSLIHSLIEESQNQQEKQ-NH2	722
817	Ac-QIWNNMTWMEWDREINNYTSLIHSLIEESQQQQEKN-NH2	723
818	Ac-QIWNNMTWMEWDREINNYTSLIHSLIEESQQQQEKQ-NH2	724
819	Ac-NKSLEQIWNNMTWMEWDREINNYTSLIHSLIEESQQ-NH2	725
820	Ac-FDASISQVNEKINQSLAFIEESDELLHNVNAGKST-NH2	726
821	Ac-ACIRKSDELCL-NH2	727
823	Ac-YTSLIHSLIEESQNQQEKDEQELLELDKWASLWNWF-NH2	728
824	Ac-YTSLIHSLIEESQDQQEKNEQELLELDKWASLWNWF-NH2	729
825	Ac-YTSLIHSLIEESQDQQEKDEQELLELDKWASLWNWF-NH2	730
826	Ac-YTSLIHSLIEESQNQQEKNEQELLELDKWASLWDWF-NH2	731
841	Ac-LEANITQSLEQAQIQQEKNMYELQKLNSWDVFTNWLNH2	732
842	Ac-LEANISASLEQAQIQQEKNMYELQKLNSWDVFTNWL-NH2	733
843	Ac-LEANISALLEQAQIQQEKNMYELQKLNSWDVFTNWL-NH2	734
844	Ac-LEAMTALLEQAQIQQEKNMYELQKLNSWDVFTNWL-NH2	735
845	Ac-LEAMTASLEQAQIQQEKNMYELQKLNSWDVFTNWL-NH2	736
845	Ac-LEAMTASLEQAQIQQEKNMYELQKLNSWDVFTNWL-NH2	736
846	Ac-RAKFKQLLQHYREVAAAKSSENDRLRLLLKQMUPS-NH2	737
847	Ac-Abu-DDE-Abu-MNSVKNGTYDYPKYEEESKLNRNEIKGVKL-NH2	738
856	Ac-WQEWEQKVRYLEANISQSLEQAQIQQEKNMYELQKL-NH2	739
860	Ac-DEYDASISQVNEKiNQSLAFIRKSDELLHNVNAGK-NH2	740
861	Ac-YTSLIHSLIEESQNQQEKNEQELLELDKWASLWN-NH2	741
862	Ac-YTSLIHSLIEESQNQQEKNEQELLELDKWASLW-NH2	742
863	Ac-YTSLIHSLIEESQNQQEKNEQELLELDKWASL-NH2	743
864	Ac-YTSLIHSLIEESQNQQEKNEQELLELDKWAS-NH2	744
865	Ac-QARQLLSGWQQQNNLLRAIEAQQHLLQLTVWGIKQLQARILAVERYLKDQ-NH2	745
866	Ac-DREINNYTSLIHSLIEESQNQQEKNEQELLELDKWASLWNWF-NH2	746
867	Ac-NNMTWMEWDREINNYTSLIHSLIEESQNQQEKNEQELLELDK-NH2	747
868	Ac-YTSLIHSLIEESQNQQEKNEQELLELDKWASLWAAA-NH2	748
869	Ac-YTSLIHSLIEESQN9QEKNEQELLELDKWAAAANWF-NH2	749
870	Ac-YTSLIHSHEESQNQQEKNEQELLELDAAASLWNWF-NH2	750
871	Ac-YTSLIHSLIEESQNQQEKNEQELLAAAKWASLWNWF-NH2	751
872	Ac-YTSLIHSLIEESQNQQEKNEQAAAELDKWASLWNWF-NH2	752
873	Ac-YTSLIHSLIEESQNQQEKAAAELLELDKWASLWNWF-NH2	753
874	Ac-YTSLIHSLIEESQNQAAANEQELLELDKWASLWNWF-NH2	754
875	Ac-YTSLIHSLIEESAAAQEKNEQELLELDKWASLWNWF-NH2	755
876	Ac-YTSLIHSLIAAAQNQQEKNEQELLELDKWASLWNWF-NH2	756
877	Ac-YTSLIHAAAEESQNQQEKNEQELLELDKWASLWNWF-NH2	757
878	Ac-YTSAAASLIEESQNQQEKNEQELLELDKWASLWNWF-NH2	758
879	Ac-EIWNNMTWMEWDRENEKINQSLAFIRKSDELLHNV-NH2	759
880	Ac-YISEVNEEINQSLAHRKADELLENVDKWASLWNWF-NH2	760
881	Ac-TSVITIELSMKENKANGTDAKVKLIKQELDKYKN-NH2	761
882	YTSLIHSLlEESQNQQEKNEQELLELDKWASLWNWFMG-NH2	762
883	Ac-NEKINQSLAFIRKSDELLHNV-NH2	763
884	Biotin-YDPLVFPSDEFDASISQVNEKINQSLAFIRKSDEL-NH2	764
885	Biotin-PLVFPSDEFDASISQVNEKINQSLAFIRKSDELLH-NH2	765
886	Biotin-VFPSDEFDASISQVNEKINQSLAFIRKSDELLHNV-NH2	766
887	Biotin-DEFDASISQVNEKINQSLAFIRKSDELLHNVNAGK-NH2	767
888	Biotin-VYPSDEFDASISQVNEKINQSLAFIRKSDELLHNV-NH2	768
889	Biotin-VYPSDEYDASISQVNEEINQALAYIRKADELLENV-NH2	769
890	Ac-VYPSDEFDASISQVQEEIQQALAFIRKADELLEQV-NH2	770
891	Ac-NYTSLIHSLIEESQNQQEKNEQELLELDKWASLWNWF-NH2	771
892	Ac-NNYTSLIHSLIEESQNQQEKNEQELLELDKWASLWNWF-NH2	772
893	Ac-INNYTSLIHSLIEESQNQQEKNEQELLELDKWASLWNWF-NH2	773
894	Ac-EINNYTSLIHSLIEESQNQQEKNEQELLELDKWASLWWWF-NH2	774
895	Ac-YTSLIHSLIEESQNQQEKNEQELLELDKWASLWNWFN-NH2	775
896	Ac-YTSLIHSLIEESQNQQEKNEQELLELDKWASLWNWFM-NH2	776
897	Ac-YTSLIHSLIEES9NQQEKNEQELLELDKWASLWNWFNIT-NH2	777
898	Ac-YTSLIHSLIEESQNQQEKNEQELLELDKWASLWNWFNITN-NH2	778
899	Ac-YDPLVFPSDEFDASISQVNEKINQSLAHRKSDELLHNVNAGK-NH2	779
900	Ac-NYTSLIHSHEESQNQQEKNEQELLELDKWASLWNWFN-NH2	780
901	Ac-NNYTSLIHSLIEESQNQQEKNEQELLELDKWASLWNWFNI-NH2	781
905	Ac-KCRAKFKQLLQHYREVAAAKSSENDRLRLLLKQMCPSLDVDSIIPRTPD-NH2	782
906	Ac-RAKFKQLLQHYREVAAAKSSENDRLRLLLKQMCPSLDVDSIIPRTPD-NH2	783
907	Ac-VYPSDEYDASISQVNEEINQALAYIAAADELLENV-NH2	784
909	Ac-YDASISQVNEEINQALAYIRKADELL-NH2	785
910	Ac-M-Nle-WMEWDREINNYTSLIHSLIEESQNQQEKNEQELLEL-NH2	786
911	Ac-KNGTYDYPKYEEESKLNRNEIKGVKLSSMGVYQI-NH2	787
912	Ac-VTEKIQMASDNINDLIQSGVNTRLLTIQSHVQNYI-NH2	788
913	QNQQEKNEQELLELDKWASLWNWF-NH2	789
914	Ac-QNQQEKNEQELLELDKWASLWNWF-NH2	790
915	LWNWF-NH2	791
916	ELLELDKWASLWNWF-NH2	792
917	EKNEQELLELDKWASLWNWF-NH2	793
918	SLIEESQNQQEKNEQELLELDKWASLWNWF-NH2	794
919	Ac-YTSLIHSLIEESQNQQEKNEQELLELDKWASLWNW	795
920	Ac-YTSLIHSLIEESQNQQEKNEQELLELDKWASLWN	796
921	Ac-YTSLIHSLIEESQNQQEKNEQELLELDKWASLW	797
922	Ac-YTSLIHSLIEESQNQQEKNEQELLELDKWASL	798
923	TSHHSLIEESQNQQEKNEQELLELDKWASLWNWF-NH2	799
924	SLIHSLIEESQNQQEKNEQELLELDKWASLWNWF-NH2	800
925	LIHSLIEESQNQQEKNEQELLELDKWASLWNWF-NH2	801
926	IHSLIEESQNQQEKNEQELLELDKWASLWNWF-NH2	802
940	Ac-AAVALLPAVLLALLAPSELEIKRYKNRVASRKCRAKFKQLLQHYREVAAAK-NH2	803
941	Ac-AAVALLPAVLLALLAPCRAKFKQLLQHYREVAAAKSSENDRLRLLLKQMCP-NH2	804
942	Ac-YTSLIHSLIEESQNQQEKNNNIERDWEMWTMNNWIQ-NH2	805
944	VYPSDEYDASISQVNEEINQALAYIRKADELLENV-NH2	806
945	Ac-LMQLARQLMQLARQMKQLADSLMQLARQVSRLFSA-NH2	807
946	Ac-WMEWDREINNYTSLIHSLIEESQNQQEKNEQELL-NH2	808
947	Ac-MEWDREINNYTSLIHSLIEESQNQQEKNEQELLEL-NH2	809
948	Ac-EWDREINNYTSLIHSLIEESQNQQEKNEQELLEL-NH2	810
949	Ac-MEWDREINNYTSLIHSLIEESQNQQEKNEQELLE-NH2	811
950	Biotin-W-Nle-EWDREINNYTSLIHSLIEESQNQQEKNEQELLEL-NH2	812
951	Ac-YLEYDREINNYTSLIHSLIEESQN9QEKNEQELLEL-NH2	813
952	Ac-IKQFINMWQEVGKAMYA-NH2	814
953	Ac-IRKSDELL-NH2	815
954	Decanoyl-IRKSDELL-NH2	815
955	Acetyl-Aca-Aca-IRKSDELL-NH2	815
956	Ac-YDASISQV-NH2	816
957	Ac-NEKINQSL-NH2	817
958	Ac-SISQVNEEINQALAYIRKADELL-NH2	818
959	Ac-QVNEEINQALAYIRKADELL-NH2	819
960	Ac-EEINQALAYIRKADELL-NH	820
961	Ac-NQALAYIRKADELL-NH2	821
962	Ac-LAYIRKADELL-NH2	822
963	FDASISQVNEKINQALAFIRKSDELL-NH2	823
964	Ac-W-Nle-EWDREINNYTSLIHSLIEESQNQQEKNEQELLEL-NH2	824
965	Ac-ASRKCRAKFKQLLQHYREVAAAKSSENDRLRLLLKQMCPSLDVDS-NH2	825
967	Ac-WLEWDREINNYTSLIHSLIEESQNQQEKNEQELLEL-NH2	827
968	Ac-YVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSL-NH2	828
969	Ac-VYPSDEYDASISQVNEEINQSLAYIRKADELLHNV-NH2	829
970	Ac-YDASISQVNEEINQALAYIRKADELLENV-NH2	830
971	Ac-YDASISQVNEEINQALAYIRKADELLE-NH2	831
972	Ac-VYPSDEYDASISQVNEEINQALAYIRAAAELLHNV-NH2	832
973	Ac-VYPSDEYDASISQVNEEINQALAYIRKALELLHNV-NH2	833
974	Decanoyl-YTSLIHSLIEESQNQQEKNEQELLELDKWASLWNWF-NH2	834
975	Ac-VYPSDEYDASISQVNEEINQLLAYIRKLDELLENV-NH2	835
976	Ac-DEYDASISQVNEKINQSLAFIRKSDELL-NH2	836
977	Ac-SNDQGSGYAADKESTQKAFDGITNKVNSVIEKTNT-NH2	837
978	Ac-ESTQKAFDGITNKVNSVIEKTNTQFEAVGKEFGNLEKR-NH2	838
979	Ac-DGITNKVNSVIEKTNTQFEAVGKEFGNLEKRLENLNK-NH2	839
980	Ac-DSNVKNLYDKVRSQLRDNKKELGNGAFEFYHK-NH2	840
981	Ac-RDNKKELGNGAFEFYHKADDEALNSVKNGTYDYPKY-NH2	841
982	Ac-EFYHKADDEALNSVKNGTYDYPKY-NH2	842
983	Ac-AAVALLPAVLLALLAPAADKESTQKAFDGITNKVNS-NH2	843
984	Ac-AAVALLPAVLLALLAPAADSNVKNLYDKVRSQLRDN-NH2	844
985	Ac-KESTQKAFDGITNKVNSV-NH2	845
986	Ac-IEKTNTQFEAVGKEFGNLER-NH2	846
987	Ac-RLENLNKRVEDGFLDVWTYNAELLVALEME-NH2	847
988	Ac-SNVKNLYDKVRSQLRDN-NH2	848
989	Ac-WMEWDREINNYTSLIHSLIEESQNQQEKNEQEL-NH2	849
990	Ac-WMEWDREINNYTSLIHSLIEESQNQQEKNEQE-NH2	850
991	Ac-MEWDREINNYTSLIHSLIEESQNQQEKNEQEL-NH2	851
992	Ac-MEWDREINNYTSuHSLIEESQNQQEKNEQE-NH2	852
993	Ac-EWDREINNYTSLIHSLIEESQNQQEKNEQELLE-NH2	853
994	Ac-EWDREINNYTSLIHSHEESQNQQEKNEQELL-NH2	854
995	Ac-EWDREINNYTSLIHSLIEESQNQQEKNEQEL-NH2	855
996	Ac-YTKFIYTLLEESQNQQEKNEQELLELDKWASLWNWF-NH2	856
997	Ac-YMKQLADSLMQLARQVSRLESA-NH2	857
998	Ac-YLMQLARQMKQLADSLMQLARQVSRLESA-NH2	858
999	Ac-YQEWERKVDFLEENITALLEEAQIQQEKNMYELQKL-NH2	859
1000	Ac-WMAWAAAINNYTSLIHSLIEESQNQQEKNEQEEEEE-NH2	860
1001	Ac-YASLIAALIEESQNQQEKNEQELLELAKWAALWAWF-NH2	861
1002	[Ac-EWDREINNYTSLIHSLIEESQNQQEKNEQEGGC-NH2]dimer	862
1003	Ac-YDISIELNKAKSDLEESKEWIKKSNQKLDSIGNWH-NH2	863
1004	Biotinyl-IDISIELNAAKSDLEESKEWIKKSNQKLDSIGNWH-NH2	864
1005	Ac-YTSLI-OH	865
1006	Fmoc-HSLIEE-OH	866
1007	Fmoc-SQNQQEK-OH	867
1008	Fmoc-NEQELLEL-OH	868
1009	Fmoc-DKWASL-OH	869
1010	Fmoc-WNWF-OH	870
1011	Ac-AKTLERTWDTLNHLLFISSALYKLNLKSVAQITLSI-NH2	871
1012	Ac-MTLQAKIKQFINMWQEVGKAMYA-NH2	872
1013	Ac-LENERTLDFHDSNVKNLYDKVRLQLRDN-NH2	873
1014	Ac-LENERTLDFHDSNVKNLYDKVRLQLRDNVKELGNG-NH2	874
1015	Ac-TLDFHDSNVKNLYDKVRLQLRDNVKELGNGAFEF-NH2	875
1016	Ac-IDISIELNKAKSDLEESKEWIKKSNQKLDSIGNWH-NH2	876
1021	Biotinyl-SISQVNEEINQALAYIRKADELL-NH2	877
1022	Biotinyl-SISQVNEEINQSLAYIRKSDELL-NH2	878
1023	Ac-SISQVNEEINQSLAYIRKSDELL-NH2	879
1024	Ac-IDISIFLNKAKSDLEESKEWIEKSNQELDSIGNWE-NH2	39
1025	Ac-IDISIELNKAKSDLEESKEWIKKSNQELDSIGNWH-NH2	864
1026	Ac-IDISIELNKAKSDLEEAKEWIDDANQKLDSIGNWH-NH2	79
1027	Ac-IDISIELNKAKSDLEESKEWIKKANQKLDSIGNWH-NH2	80
1028	Ac-IDISIELNKAKSDLEEAKEWIKKSNQKLDSIGNWH-NH2	548
1029	Biotinyl-NSVALDPIDISIELNKAKSDLEESKEWIKKSNQKL-NH2	880
1030	Biotinyl-ALDPIDISIELNKAKSDLEESKEWIKKSNQKLDSI-NH2	881
1031	desAminoTyrosine-NSVALDPIDISIELNKAKSDLEESKEWIKKSNQKL-NH2	882
1032	desAminoTyrosine-ALDPIDISIELNKAKSDLEESKEWIKKSNQKLDSI-NH2	883
1033	Ac-YDASISQVNEEINQALAFIRKADEL-NH2	984
1034	Ac-YDASISQVNEEINQSLAYIRKADELL-NH2	985
1035	Biotinyl-YDASISQVNEEINQALAYIRKADELL-NH2	986
1036	Biotinyl-YDASISQVNEEINQSLAFIRKSDELL-NH2	987
1037	Ac-YDASISQVNEEINQSLAFIRKSDELL-NH2	988
1038	Ac-WLEWDREINNYTSLIHSLIEESQNQQEKNEQEL-NH2	989
1039	Biotinyl-IDISIELNKAKSDLEESKEWIRRSNQKLDSIGNWH-NH2	916
1044	Ac-YESTQKAFDGITNKVNSVIEKTNTQFEAVGKEFGNLEKR-NH2	81
1045	Biotin-DEYDASISQVNEKINQSLAFIRKSDELL-NH2	82
1046	Ac-MEWDREINNYTSLIHSLIEESQNQQEKNEQELL-NH2	90
1047	Ac-WQEWEQKVRYLEANISQSLEQAQIQQEKNMYEL-NH2	892
1048	Ac-WQEWEQKVRYLEAMSQSLEQAQIQQEKNEYEL-NH2	893
1049	Ac-WQEWEQKVRYLEANITALLEQAQIQQEKNEYEL-NH2	894
1050	Ac-WQEWEQKVRYLEANITALLEQAQIQQEKNMYEL-NH2	895
1051	Ac-WQEWEQKVRYLEANISQSLEQAQIQQEKNEYELQKL-NH2	896
1052	Ac-WQEWEQKVRYLEANITALLEQAQIQQEKNEYELQKL-NH2	897
1053	Ac-WQEWEQKVRYLEAMTALLEQAQIQQEKNMYELQKL-NH2	898
1054	Ac-IDISIELNKAKSDLEESKEWIEKSNQKLDSIGNWH-NH2
1055	Ac-EFGNLEKRLENLNKRVEDGFLDVWTYNAELLVALENE-NH2	899
1056	Ac-EDGFLDVWTYNAELLVLMENERTLDFHDSNKKNLYDKVRMQL-NH2	900
1057	Ac-SISQVNEKINQSLAFIRKSDELL-NH2	901
1058	desaminoTyr-SISQVNEKINQSLAFIRKSDELL-NH2	902
1059	Ac-SISQVNEKINQSLAYIRKSDELL-NH2	903
1060	Ac-QQLLDVKKRQQEMLRLTVWGTKNLQARVTAIEKYLKDQ-NH2	904
1061	YTSLIHSLIEESQNQQEKNEQELLELDKWASLWNWFC	905
1062	Ac-FDASISQVNEKINQSLAYIRKSDELL-NH2	906
1063	Ac-YTSLIHSHEESQNQQEKNEQELLELDKWA	907
1064	Indole-3-acetyl-DEFDASISQVNEKINQSLAFIRKSDELL-NH2	908
1065	Indole-3-acetyl-DEFDESISQVNEKINQSLAFIRKSDELL-NH2	909
1066	Indole-3-acetyl-DEFDESISQVNEKIEQSLAFIRKSDELL-NH2	910
1067	Indole-3-acetyl-DEFDESISQVNEKIEESLAFIRKSDELL-NH2	911
1068	Indole-3-acetyl-DEFDESISQVNEKIEESLQFIRKSDELL-NH2	912
1069	Indole-3-acetyl-GGGGGDEFDASISQVNEKINQSLAFIRKSDELL-NH2	913
1070	2-Napthoyl-DEFDASISQVNEKINQSLAFIRKSDELL-NH2	914
1071	desNH2Tyr-DEFDASISQVNEKINQSLAFIRKSDELL-NH2	915
1072	biotin-ALDPIDISIELNKAKSDLEESKEWIRRSNQKLDSI-NH2	916
1073	Ac-YDASISQVNEKINQALAYIRKADELLHNvNAGKST-NH2	917
1074	Ac-VYPSDEYDASISQVNEKINQALAYIRKADELLHNV-NH2	918
1075	Ac-VYPSDEYDASISQVNEKINQSLAYIPKSDELLHNV-NH2	718
1076	Ac-WGWGYGYG-NH2	919
1077	Ac-YGWGWGWGF-NH2	920
1078	Ac-WQEWEQKVRYLEANITALQEQAQIQAEKAEYELQKL-NH2	921
1079	Ac-WQEWEQKVRYLEAEITALQEEAQIQAEKAEYELQKL-NH2	922
1081	Ac-YTSLIHSLIEESQNQQEKNEQELLELDKWAS	923
1082	Ac-VWPSDEFDASISQVNEKINQSLAFIRKSDELLHNV-NH2	924
1083	Ac-SKNISEQIDQIKKDEQKEGTGWGLGGKWWTSDWGV-NH2	925
1084	Ac-LSKNISEQIDQIKKDEQKEGTGWGLGGKWWTSDWG-NH2	926
1085	Ac-DLSKNISEQIDQIKKDEQKEGTGWGLGGKWWTSDW-NH2	927
1086	Ac-EDLSKNISEQIDQIKKDEQKEGTGWGLGGKWWTSD-NH2	928
1087	Ac-IEDLSKNISEQIDQIKKDEQKEGTGWGLGGKWWTS-NH2	929
1088	Ac-GIEDLSKMSEQIDQIKKDEQKEGTGWGLGGKWWT-NH2	930
1089	Ac-IGIEDLSKNISEQIDQIKKDEQKEGTGWGLGGKWW-NH2	931
1090	2-Napthoyl--PSDEFDASISQVNEKINQSLAFIRKSDELLHNVN-NH2	932
1091	Ac-VYPSDEYDASISQVNEKINQALAYIRKADELLENV-NH2	933
1092	Ac-VYPSDEFDASISQVNEKINQALAFIRKADELLENV-NH2	934
1093	Ac-VYPSDEYDASISQVNEKINQALAYIREADELLENV-NH2	935
1094	Biotinyl-YDASISQVNEKINQSLAFIRESDELL-NH2	936
1095	Ac-AIGIEDLSKNISEQIDQIKKDEQKEGTGWGLGGKW-NH2	937
1096	Ac-AAIGIEDLSKNISEQIDQIKKDEQKEGTGWGLGGK-NH2	938
1097	Ac-DAAIGIEDLSKNISEQIDQIKKDEQKEGTGWGLGG-NH2	939
1098	Ac-PDAAIGIEDLSKNISEQIDQIKKDEQKEGTGWGLG-NH2	940
1099	Ac-NITDKIDQIIHDFVDKTLPDQGDNDNWWTGWRQWI-NH2	941
1100	Ac-KNITDKIDQIIHDFVDKTLPDQGDNDNWWTGWRQW-NH2	942
1101	Ac-TKNITDKIDQIIHDFVDKTLPDQGDNDNWWTGWRQ-NH2	943
1102	Ac-WTKNITDKIDQIIHDFVDKTLPDQGDNDNWWTGWR-NH2	944
1103	Ac-DWTKNITDKIDQIIHDFVDKTLPDQGDNDNWWTGW-NH2	945
1104	Ac-HDWTKNITDKIDQIIHDFVDKTLPDQGDNDNWWTG-NH2	946
1105	Ac-PHDWTKNITDKIDQIIHDFVDKTLPDQGDNDNWWT-NH2	947
1106	Ac-EPHDWTKNITDKIDQIIHDFVDKTLPDQGDNDNWW-NH2	948
1107	Ac-IEPHDWTKNITDKIDQIIHDFVDKTLPDQGDNDNW-NH2	949
1108	Ac-AIEPHDWTKNITDKIDQIIHDFVDKTLPDQGDNDN-NH2	950
1109	Ac-AAIEPHDWTKNITDKIDQIIHDFVDKTLPDQGDND-NH2	951
1110	Ac-DAAIEPHDWTKNITDKIDQIIHDFVDKTLPDQGDN-NH2	952
1111	Ac-LSPTVWLSVIWMMWYWGPSLYSILSPFLPLLPIFF-NH2	953
1112	Ac-GLSPTVWLSVIWMMWYWGPSLYSILSPFLPLLPIF-NH2	1345
1113	Ac-VGLSPTVWLSVIWMMWYWGPSLYSILSPFLPLLPI-NH2	1346
1114	Ac-FVGLSPTWLSVIWMMWYWGPSLYSILSPFLPLLP-NH2	1347
1115	Ac-WFVGLSPTVWLSVIWMMWYWGPSLYSILSPFLPLL-NH2	1348
1116	Ac-QWFVFLSPTVWLSVIWMMWYWGPSLYSILSPFLPL-NH2	1349
1117	Ac-VQWFVGLSPTVWLSVIWMMWYWGPSLYSILSPFLP-NH2	1350
1118	Ac-FVQWFVGLSPTVWLSVIWMMWYWGPSLYSILSPFL-NH2	1351
1119	Ac-PFVQWFVGLSPTVWLSVIWMMWYWGPSLYSILSPF-NH2	1352
1120	Ac-VPFVQWFVGLSPTVWLSVIWMMWYWGPSLYSILSP-NH2	1353
1121	Ac-LVPFVQWFVGLSPTVWLSVIWMMWYWGPSLYSILS-NH2	1354
1122	H-NHTTWMEWDEREINNYTSLIHSLIEESQNQQEKNEQELLELDKW-OH	954
1123	H-QARQLLSGIVQQQNNLLRAEIAQQHLLQLTVWGIKQLQARILAVERYLKDQ-OH	955
1124	Ac-VYPSDEFDASISQVNEKINQSLAFIREADELLENV-NH2	956
1125	AcNFPSDEFDASISQVNEKWQSLAYIREADELLENV-NH2	957
1126	Ac-DEFDASISQVNEKWQSLAYIREADELL-NH2	958
1127	Ac-NEQELLELDKWASLWNWFGGGGDEFDASISQVNEKWQSLAFIRKSDELL-NH2	959
1128	Ac-LELDKWASLWNWFGGGGDEFDASISQVNEKWQSLAFIRKSDELL-NH2	960
1129	Naphthoyl-EGEGEGEGDEFDASISQVNEKWQSLAFIRKSDELL-NH2	961
1130	Ac-ASRKCRAKFKQLLQHYREVAAAKSSENDRLRLLLKQMCPSLDV-NH2	962
1131	Naphthoyl-GDEEDASISQVNEKWQSLAFIRKSDELL-NH2	963
1132	Naphthoyl-GDEEDASESQVNEKWQSLAFIRKSDELL-NH2	964
1133	Naphthoyl-GDEEDASESQQNEKWQSLAFIRKSDELL-NH2	965
1134	Naphthoyl-GDEEDASESQQNEKQNQSLAFIRKSDELL-NH2	966
1135	Naphthoyl-GDEEDASESQQNEKQNQSEAFIRKSDELL-NH2	967
1136	Ac-WGDEFDESISQVNEKIEESLAFIRKSDELL-NH2	968
1137	Ac-YTSLGGDEFDESISQVNEKIEESLAFIRKSDELLGGWNWF-NH2	969
1138	Ac-YTSLIHSLGGDEFDESISQVNEKIEESLAFIRKSDELLGGWASLWNWF-NH	970
1139	2-Naphthoyl-GDEFDESISQVNEKIEESLAFIRKSDELL-NH2	971
1140	2-Naphthoyl-GDEEDESISQVNEKIEESLAFIRKSDELL-NH2	972
1141	2-Naphthoyl-GDEEDESISQVQEKIEESLAFIRKSDELL-NH2	973
1142	2-Naphthoyl-GDEEDESISQVQEKIEESLLFIRKSDELL-NH2	974
1143	Biotin-GDEYDESISQVNEKIEESLAFIRKSDELL-NH2	975
1144	2-Naphthoyl-GDEYDESISQVNEKIEESLAFIRKSDELL-NH2	976
1145	Ac-YTSLIHSLIDEQEKIEELAFIRKSDELLELDKWNWF-NH2	977
1146	VYPSDEYDASISQVNEEWQALAYIRKADELLENV-NH2	978
1147	Ac-NNLLRAIEAQQHLLQLTVWGSKQLQARILAVERYLKDQ-NH2	979
1148	GGGVYPSDEYDASISQVNEEWQALAYIRKADELLENV-NH2	980
1149	Ac-NNLLRAIEAQQHLLQLTVWGEKQLQARILAVERYLKDQ-NH2	981
1150	Ac-PTRVNYILIIGVLVLAbuEVTGVRADVHLL-NH2	982
1151	Ac-PTRVNYILIIGVLVLAbuEVTGVRADVHLLEQPGNLW-NH2	983
1152	Ac-PEKTPLLPTRVNYILIIGVLVLAbuEVTGVRADVHLL-NH2	984
1153	AhaGGGVYPSDEYDASISQVNEEWQALAYIRAADELLENV-NH2	985
1155	Ac-YTSLIHSLGGDEFDESISQVNEKIEESLAFIRKSDELL-NH2	986
1156	Ac-YTSLGGDEFDESISQVNEKIEESLAFIRKSDELL-NH2	987
1157	Ac-DEFDESISQVNEKIEESLAFIRKSDELLGGWASLWNWF-NH2	988
1158	Ac-DEFDESISQVNEKIEESLAFIRKSDELLGGWNWF-NH2	989
1159	Ac-YTSLIHSLIEESQNQQEKNEQELLELDKASLWNWF-NH2	990
1160	Ac-YTSLIHSLIEESQNQQEKNEQELLELDKSLWNWF-NH2	991
1161	Ac-YTSLIHSLIEESQNQQEKNEQELLELDKLWNWF-NH2	992
1162	Ac-YTSLIHSLIEESQNQQEKNEQELLELDKWNWF-NH2	993
1163	Ac-MTWMEWDREWNYTSLIHSLIEESQNQQEKNEQELLELDKASLWNWF-NH2	994
1164	Ac-MTWMEWDREWNYTSLIHSLIEESQNQQEKNEQELLELDKSLWNWF-NH2	995
1165	Ac-MTWMEWDREWNYTSLIHSLIEESQNQQEKNEQELLELDKLWNWF-NH2	996
1166	Ac-MTWMEWDREWNYTSLIHSLIEESQNQQEKNEQELLELDKWNWF-NH2	997
1167	Ac-MTWMEWDREWNYTSLIHSLIEESQNQQEKNEQELLELDKWASLWN-NH2	998
1168	Ac-MTWMEWDREINNYTSLIHSLIEESQNQQEKNEQELLELDKWASL-NH2	999
1169	(Pyr)HWSY(2-napthyl-D-Ala)LRPG-NH2	1000
1170	Ac-WNWFDEFDESISQVNEKIEESLAFIRKSDELLWNWF-NH2	1001
1171	Ac-YTSLIHSLIEESQNQQEKNEQELLELDKYASLYYYF-NH2	1002
1172	Ac-YTSLIHSLIEESQNQQEKNEQELLELDKYAYLYNYF-NH2	1003
1173	2-NaphthoAcaAcaAcaDEFDESISQVNEKIEESLAFIRKSDELLAcaAcaAcaW-NH2	1004
1174	2-Naphthoyl-AcaAcaAcaGDEFDESISQVNEKIEESLAFIRKSDELLGAcaAcaAcaW-NH2	1005
1175	2-Naphthoyl-GDEFDESISQVNEKIEESLAFIRESDELL-NH2	1006
1176	2-Naphthoyl-GDEFDESISQVNEKIEESLAFIEESDELL-NH2	1007
1177	Ac-WQEWEQKVNYLEANITALLEQAQIQQEKNEYELQKL-NH2	1008
1178	Ac-WQEWEQKVDYLEANITALLEQAQIQQEKNEYELQKL-NH2	1009
1179	Ac-WQEWEQKVRWLEAMTALLEQAQIQQEKNEYELQKL-NH2	1010
1180	Ac-WQEWEKQVRYLEANITALLEQAQIQQEKNEYELQKL-NH2	1011
1181	Ac-WQEWEHQVRYLEANITALLEQAQIQQEKNEYELQKL-NH2	1012
1182	Ac-WQEWEHKVRYLEANITALLEQAQIQQEKNEYELQKL-NH2	1013
1183	Ac-WQEWDREVRYLEAMTALLEQAQIQQEKNEYELQKL-NH2	1014
1184	Ac-WQEWEREVRYLEANITALLEQAQIQQEKNEYELQKL-NH2	1015
1185	Ac-WQFWERQVRYLEANITALLEQAQIQQEKNEYELQKL-NH2	1016
1186	Ac-WQEWEQKVKYLEANITALLEQAQIQQEKNEYELQKL-NH2	1017
1187	Ac-WQEWEQKVRFLEANITALLEQAQIQQEKNEYELQKL-NH2	1018
1188	Ac-VNalPSDEYDASISQVNEEINQALAYIRKADELLENV-NH2	1019
1189	Ac-VNalPSDENalDASISQVNEEINQALAYIRKADELLENV-NH2	1020
1190	Ac-VNalPSDEYDASISQVNEEINQALANalIRKADELLENV-NH2	1021
1191	Ac-VYPSDEFDASISQVNEKINQSLAFIREADELLFNFF-NH2	1022
1192	Ac-VYPSDEYDASISQVNEEINQALAYIRKADELLFNFF-NH2	1023
1193	Ac-YTSLITALLEQAQIQQEKNEYELQKLDKWASLWNWF-NH2	1024
1194	Ac-YTSLITALLEQAQIQQEKNEYELQKLDKWASLWEWF-NH2	1025
1195	Ac-YTSLITALLEQAQIQQEKNEYELQKLDEWASLWEWF-NH2	1026
1196	Ac-YTSLITALLEQAQIQQEKNEYELQELDEWASLWEWF-NH2	1027
1197	Ac-YTSLITALLEEAQIQQEKNEYELQELDEWASLWEWF-NH2	1028
1198	Naphthoyl-Aua-Aua-Aua-TALLEQAQIQQEKNEYELQKLAua-Aua-Aua-W-NH2	1029
1199	Ac-WAAWEQKVRYLEAMTALLEQAQIQQEKNEYELQKL-NH2	1030
1200	Ac-WQEAAQKVRYLEANITALLEQAQIQQEKNEYELQKL-NH2	1031
1201	Ac-WQEWAAKVRYLEANITALLEQAQIQQEKNEYELQKL-NH2	1032
1202	Ac-WQAAEQKVRYLEANITALLEQAQIQQEKNEYELQKL-NH2	1033
1203	Ac-WQEWEAAVRYLEAMTALLEQAQIQQEKNEYELQKL-NH2	1034
1204	Ac-WQEWEQAARYLEAMTALLEQAQIQQEKNEYELQKL-NH2	1035
1205	Ac-WQEWEQKAAYLEAMTALLEQAQIQQEKNEYELQKL-NH2	1036
1206	Ac-WQEWEQKVAALEANITALLEQAQIQQEKNEYELQKL-NH2	1037
1207	Ac-WQEWEQKVRYLEANITALLEQAQIQQEKNEYELQKLGGGGWASLWNF-NH2	1038
1208	2-Naphthoyl-GDEFDASISQVNEKINQSLAFIRKSDELT-NH2	1039
1209	2-Naphthoyl-GDEFDASISQVNEKINQSLAFTRKSDELT-NH2	1040
1210	2-Naphthoyl-GDEFDASISQVNEKTNQSLAFTRKSDELT-NH2	971
1211	2-Naphthoyl-GDEFDASISQTNEKTNQSLAFTRKSDELT-NH2	1038
1212	2-Naphthoyl-GDEFDASTSQTNEKTNQSLAFTRKSDELT-NH2	1039
1213	2-Naphthoyl-GDEYDASTSQTNEKTNQSLAFTRKSDELT-NH2	1040
1214	2-Naphthoyl-GDEFDEEISQVNEKIEESLAHRKSDELL-NH2	1041
1215	2-Naphthoyl-GDEFDASISQVNEKINQSLAFIRKSDELA-NH2	1042
1216	2-Naphthoyl-GDEFDASASQANEKANQSLAFARKSDELA-NH2	1043
1217	2-Naphthoyl-GDEFDESISQVNEKIEESLAFTRKSDELL-NH2	1044
1218	2-Naphthoyl-GDEFDESISQVNEKTEESLAFIRKSDELL-NH2	1045
1219	2-Naphthoyl-GDEFDESISQTNEKIEESLAFIRKSDELL-NH2	1046
1220	2-Naphthoyl-GDEFDESTSQVNEKIEESLAFIRKSDELL-NH2	1047
1221	Ac-WNWFDEFDESTSQVNEKIEESLAFIRKSDELLWNWF-NH2	1048
1222	Ac-WNWFDEFDESTSQTNEKIEESLAFIRKSDELLWNWF-NH2	1049
1223	Ac-WNWFDEFDESTSQTNEKTEESLAFIRKSDELLWNWF-NH2	1050
1224	Ac-LQAGFFLLTRILTIPQSLDSWWTSLNFLGGTTVAL-NH2	1355
1225	Ac-YTNLIYTLLEESQNQQEKNEQELLELDKWASLWSWF-NH2	1051
1226	Ac-WQEWEQKVRYLEANITALLEQAQIQQEKNEYELQKLDKWASLWNWF-NH2	1052
1227	Ac-NNMTWQEWEQKVRYLEANITALLEQAQIQQEKNEYELQKLDKWASLWNWF-NH2	1053
1230	Ac-WWWFIEESDELLWNWF-NH2	1054
1231	2-Naphthoyl-GFIEESDELLW-NH2	1055
1232	Ac-WFIEESDELLW-NH2	1056
1233	2-Naphthoyl-GFNFFIEESDELLFNFF-NH2	1057
1234	2-Naphthoyl-GESDELW-NH2	1058
1235	Ac-WNWFGDEFDESISQVQEEIEESLAFIEESDELLGGWNWF-NH2	1059
1236	Ac-WNWFIHSLIEESQNQQEKNEQELLELDKWASLWNWF-NH2	1356
1237	Ac-YTSLITALLEQAQIQQEENEYELQALDEWASLWEWF-NH2	1025
1238	Ac-YTSLIHSLGGDEFDESISQVNEEIEESLAFIEESDELLGGWASLWNWF-NH2	1060
1239	2-Naphthoyl-GDEFDESISQVQEEIEESLAFIEESDELL-NH2	1061
1240	H-QARQLLSSIMQQQNNLLRAIEAQQHLLQLTVWGIKQLQARILAVERYLKDQ-OH	1062
1241	Ac-CPKYVKQNTLKLATGMRNVPEKQTR-NH2	1063
1242	Ac-GLFGAIAGFIENGWEGMIDGWYGFRHQNSC-NH2	1064
1243	Ac-LNFLGGT-NH2	1065
1244	Ac-LDSWWTSLNFLGGT-NH2	1066
1245	Ac-ILTIPQSLDSWWTSLNFLGGT-NH2	1067
1246	Ac-GFFLLTRILTIPQSLDSWWTSLNFLGGT-NH2	1068
1247	Ac-WQEWEQKITALLEQAQIQQEKNEYELQKLDKWASLWNWF-NH2	1069
1248	Ac-WNWFITALLEQAQIQQEKNEYELQKLDKWASLWNWF-NH2	1070
1249	Ac-WQEWEQKlTALLEQAQIQQEKNEYELQKLDKWASLWEWF-NH2	1071
1250	Ac-WQEWEQKVRYLEANITALLEQAQIQQEKIEYELQKL-NH2	1072
1251	Ac-WQEWEQKVRYLEAQITALLEQAQIQQEKIEYELQKL-NH2	1073
1252	Ac-KENKANGThAKVKLIKQELDKYKNAVTELQLLMQS-NH2	1074
1253	Ac-NIKENKANGTDAKVKLIKQELDKYKNAVTELQLLM-NH2	1075
1254	(FS)-YTSLIHSLIEESQNQQEKNEQELLELDKWASLWNWF-NH2	1076
1255	2-Naphthoyl-GWNWFAcaDEFDESISQVQEEIEESLAFIEESDELLAcaWNWF-NH2	1077
1256	Ac-WNWFGDEFDESISQVNEKIEESLAFIEESDELLGWNWF-NH2	1078
1257	Ac-WNWFGDEFDESISQVNEKIEESLAFIRKSDELLGWNWF-NH2	1079
1258	Ac-WNWF-Aca-DEFDESISQVNEKIEESLAFIRKSDELL-Aca-WNWF-NH2	1080
1259	Ac-WNWF-Aca-DEFDESISQVNEKIEESLAFIEESDELL-Aca-WNWF-NH2	1081
1260	Ac-EESQNQQEKNEQELLELDKWA-NH2	1082
1261	EESQNQQEKNEQELLELDKWA	1083
1262	Ac-CGTTDRSGAPTYSWGANDTDVFVLNNTRPPLGNWFG-NH2	1084
1263	Ac-GVEHRLEAACNWTRGERADLEDRDRSELSP-NH2	1085
1264	Ac-CVREGNASRAWVAVTPTVATRDGKLPT-NH2	1086
1265	Ac-CFSPRHHWTTQDANASIYPG-NH2	1087
1266	Ac-LQHYREVAAAKSSENDRLRLLLKQMCPSLDVDS-NH2	1088
1267	Ac-WQEWDREISNYTSLITALLEQAQIQQEKNEYELQKLDEWASLWEWF-NH2	1089
1268	Ac-CWQEWDREISNYTSLITALLEQAQIQQEKNEYELQKLDEWASLWEWFC-NH2	1090
1269	Ac-WQEWDREISNYTSLITALLEQAQIQQEKNEYELQKLDEWEWF-NH2	1091
1270	Ac-CWQEWDREISNYTSLITALLEQAQIQQEKNEYELQKLDEWEWFC-NH2	1092
1271	Ac-GQNSQSPTSNHSPTSAPPTAPGYRWA-NH2	1093
1272	Ac-PGSSTTSTGPARTALTTAQGTSLYPSA-NH2	1094
1273	Ac-PGSSTTSTGPARTALTTAQGTSLYPSAAATKPSDGNATA-NH2	1095
1275	Ac-WQEWDREITALLEQAQIQQEKNEYELQKLDKWASLWNWF-NH2	1097
1276	Ac-WQEWDREITALLEQAQIQQEKNEYELQKLDEWASLWEWF-NH2	1098
1277	Ac-WQEWDREITALLEQAQIQQEKNEYELQKLDEWEWF-NH2	1099
1278	Ac-WQEWDREITALLEQAQIQQEKNEYELQKLDEWEWF-NH2	1100
1279	Ac-WQEWEREITALLEQAQIQQEKNEYELQKLIEWEWF-NH2	1101
1280	Ac-WQEWEREITALLEQAQIQQEKIEYELQKLDEWEWF-NH2	1102
1281	Ac-WQEWEITALLEQAQIQQEKNEYELQKLDEWEWF-NH2	1103
1282	Ac-WQEWEITALLEQAQIQQEKNEYELQKLIEWEWF-NH2	1104
1283	Ac-WQEWEITALLEQAQIQQEKIEYELQKLDEWEWF-NH2	1105
1284	Ac-WQEWEITALLEQAQIQQEKIEYELQKLIEWEWF-NH2	1106
1285	Ac-WQEWDREDEYDASISQVNEKINQALAYIREADELWEWF-NH2	1107
1286	Ac-WQEWEREIDEYDASISQVNEKINQALAYIREADELWEWF-NH2	1108
1287	Ac-WQEWEIDEYDASISQVNEKINQALAYIREADELWEWF-NH2	1109
1288	Ac-WQEWDREIDEYDASISQVNEEINQALAYIREADELWEWF-NH2	1110
1289	Ac-WQEWEREIDEYDASISQVNEEINQALAYIREADELWEWF-NH2	1111
1290	Ac-WQEWEIDEYDASISQVNEEINQALAYIREADELWEWF-NH2	1112
1291	Ac-WQEWDEYDASISQVNEKINQALAYIREADELWEWF-NH2	1113
1292	Ac-WQEWDEYDASISQVNEEINQALAYIREADELWEWF-NH2	1114
1293	Ac-WQEWEQKITALLEQAQIQQEKiEYELQKLIEWEWF-NH2	1115
1294	Ac-WQEWEQKITALLEQAQIQQEKIEYELQKLIEWASLWEWF-NH2	1116
1295	Ac-WQEWEITALLEQAQIQQEKIEYELQKLIEWASLWEWF-NH2	1117
1298	VYPSDEYDASISQVNEEINQALAYIRKADELLENV-NH2	1160
1299	Ac-WVYPSDEYDASISQVNEEINQALAYIRKADELLENVWNWF-NH2	1120
1300	YTSLIHSLIEESQNQQEKNEQELLELDKWASLWNWF-NH2	1121
1301	Ac-WQEWDEYDASISQVNEKINQALAYIREADELWAWF-NH2	1122
1302	Ac-WQAWDEYDASISQVNEKINQALAYIREADELWAWF-NH2	1123
1303	Ac-WQAWDEYDASISQVNEKINQALAYIREADELWEWF-NH2	1124
1304	Biotin-YDPLVFPSDEFDASISQVNEKINQSLAFIRKSDEL-NH2	1125
1305	Biotin-YDPLVFPSDEFDASISQVNEKINQSLAF-NH2	1126
1306	Biotin-QVNEKINQSLAFIRKSDELLHNVNAGKST-NH2	1127
1307	Ac-WMEWDREI-NH2	1128
1308	Ac-WQEWEQKI-NH2	1129
1309	Ac-WQEWEQKITALLEQAQIQQEKIEYELQKLIKWASLWEWF-NH2	1130
1310	Ac-WQEWEQKITALLEQAQIQQEKiEYELQKLIEWASLWEWF-NH2	1131
1311	Ac-WQEWEREISAYTSLITALLEQAQIQQEKIEYELQKLIEWEWF-NH2	1132
1312	Ac-WQEWEREISAYTSLITALLEQAQIQQEKIEYELQKEWEWF-NH2	1133
1313	Ac-WQEWEREISAYTSLITALLEQAQIQQEKIEYELQKEWEW-NH2	1134
1314	Ac-WQEWEREISAYTSLITALLEQAQIQQEKIEYELQKLIEWEW-NH2	1135
1315	Ac-FNLSDHSESIQKKFQLMKKHVNKIGVDSDPIGSWLWNH2	1136
1316	Ac-DHSESIQKKFQLMKKHVNKIGVDSDPIGSWLRGIF-NH2	1137
1317	Ac-WSVKQANLTTSLLGDLLDDVTSIRHAVLQNRA-NH2	1138
1318	Biotin-WMEWDREI-NH2	1128
1319	Biotin-NNMTWMEWDREINNYTSL-NH2	1139
1320	Ac-GAASLTLTVQARQLLSGWQQQNNLLRAIEAQQHLL-NH2	1140
1321	Ac-ASLTLTVQARQLLSG4VQQQNNLLKAIEAQQHLLQL-NH2	1141
1322	Ac-VSVGNTLYYVNKQEGKSLYVKGEPIINFYDPLVF-NH2	1142
1323	Ac-QHWSYGLREG-NH2	1143
1324	Ac-WQEWEQKIQHWSYGLRPGWASLWEWF-NH2	1144
1325	Ac-WQEWEQKIQHWSYGLRPGWEWF-NH2	1145
1326	Ac-WNWFQHWSYGLRPGWNWF-NH2	1146
1327	Ac-FNFFQHWSYGLREGFNFF-NH2	1147
1328	Ac-GAGAQHWSYGLRPGAGAG-NH2	1148
1329	PLLVLQAGFFLLTRILTIPQSLDSWWTSLNFLGGT	482
1330	Ac-WQEWEQKITALLEQAQIQQEKIEYELQKLAKWASLWEWF-NH2	1149
1331	Ac-WQEWEQKlTALLEQAQIQQEKIEYELQKLAEWASLWEWF-NH2	1150
1332	Ac-WQEWEQKITALLEQAQIQQEKAEYELQKLAEWASLWEWF-NH2	1151
1333	Ac-WQEWEQKITALLEQAQIQQEKAEYELQKLAEWASLWAWF-NH2	1152
1334	Ac-WQEWEQKITALLEQAQIQQEKAEYELQKLAKWASLWAWF-NH2	1153
1335	Ac-TNKAVVSLSNGVSVLTSKVLDLKNYIDKQLLPIVNK-NH2	1154
1336	Ac-KAVVSLSNGVSVLTSKVLDLKNYIDKQLLPIVNKQS-NH2	1155
1337	Ac-WQEWEQKITALLEQAQIQQEKNEYELQKLIEWEWF-NH2	1156
1338	Ac-WQEWEQKITALLEQAQIQQEKNEYELQKLIEWEWF-NH2	1157
1339	Ac-WQEWEQKITALLEQAQIQQEKIEYELQKLDKWEWF-NH2	1158
1340	Ac-YDPLVFPSDEFDASISQVNEKINQSLAF-NH2	1159
1341	Fluor--VYPSDEYDASISQVNEEWQALAYIRKADELLENV-NH2	1160
1342	Fluor-YTSLIHSLIEESQNQQEKNEQELLELDKWASLWNWF-NH2	1161
1344	Ac-SGIVQQQNNLLRAIEAQQHLLQLTVWGIKQLQARIL-NH2	1162
1345	Ac-QQQNNLLRAIEAQQHLLQLTVWGIKQLQARILAVERYLKDQ-NH2	1163
1346	Ac-SGIVQQQNNLLRAIEAQQHLLQLTVWGIKQLQARILAVERYLKDQ-NH2	1164
1347	Ac-WQEWEQKITALLEQAQIQQEKNEYELQKLAEWASLWAWF-NH2	1165
1348	Ac-WQEWEQKITALLEQAQIQQEKNEYELQKLAEWASLWAW-NH2	1166
1349	Ac-WQEWEQKITALLEQAQIQQEKAEYELQKLAEWASLWAW-NH2	1167
1350	Ac-WQEWEQKITALLEQAQIQQEKNEYELQKLAEWAGLWAWF-NH2	1168
1351	Ac-WQEWEQKITALLEQAQIQQEKNEYELQKLAEWAGLWAW-NH2	1169
1352	Ac-WQEWEQKITALLEQAQIQQEKAEYELQKLAEWAGLWAW-NH2	1170
1353	Ac-WQEWEQKITALLEQAQIQQEKNEYELQKLDKWAGLWEWF-NH2	1171
1354	Ac-WQEWQHWSYGLRPGWEWF-NH2	1172
1355	Ac-WQAWQHWSYGLRPGWAWF-NH2	1173
1356	Biotinyl-WQEWEQKITALLEQAQIQQEKNEYELQKLDKWASLWEWF-NH2	1174
1357	WQEWEQKITALLEQAQIQQEKNEYELQKLDKWASLWEWF	1175
1358	WQEWEQKITALLEQAQIQQEKIEYELQKLIEWEWF	1176
1361	Ac-AGSTMGARSMTLTVQARQLLSGIVQQQNNLLRAIEAQQ-NH2	1179
1362	Ac-AGSAMGAASLTLSAQSRTLLAGIVQQQQQLLDVVKRQQ-NH2	1180
1363	Ac-AGSAMGAASTALTAQSRTLLAGIVQQQQQLLDVVKRQQ-NH2	1181
1364	Ac-ALTAQSRTLLAGIVQQQQQLLDVVKRQQELLRLTVWGT-NH2	1182
1365	Ac-TLSAQSRTLLAGIVQQQQQLLDVVKRQQEMLRLTVWGT-NH2	1183
1366	Ac-TLTVQARQLLSGIVQQQNNLLRAIEAQQHLLQLTVWGI-NH2	1184
1367	Ac-WQAWIEYEAELSQVKEKlEQSLAYIREADELWAWF-NH2	1185
1368	Ac-WQAWIEYEASLSQAKEKIEESKAYIREADELWAWF-NH2	1186
1369	Ac-WQAWIEYERLLVQAKLKlAIAKLYIAKELLEWAWF-NH2	1187
1370	Ac-WQAWIEYERLLVQVKLKIAIALLYIAKELLEWAWF-NH2	1188
1371	Ac-WQAWIELERLLVQVKLKLAIAKLEIAKELLEWAWF-NH2	1189
1372	Ac-GEWTYDDATKTFTVTEGGH-NH2	1190
1373	Ac-WQEWEQKIGEWTYDDATKTFTVTEGGHWASLWEWF-NH2	1191
1374	Ac-GEWTYDDATKTFTVTE-NH2	1192
1375	Ac-WQEWEQKIGEWTYDDATKTFTVTEWASLWEWF-NH2	1193
1376	Ac-MHRFDYRT-NH2	1194
1377	Ac-WQEWEQKIMHRFDYRTWASLWEWF-NH2	1195
1378	Ac-MHRFNWSTGGG-NH2	1196
1379	Ac-WQEWEQKIMHRFNWSTGGGWASLWEWF-NH2	1197
1380	Ac-MHRFNWST-NH2	1198
1381	Ac-WQEWEQKIMHRFNWSTWASLWEWF-NH2	1199
1382	Ac-LLVPLARlMTMSSVHGGG-NH2	1200
1383	Ac-WQEWEQKlLLVPLARIMTMSSVHGGGWASLWEWF-NH2	1201
1384	Ac-LLVPLARIMTMSSVH-NH2	1202
1385	Ac-WQEWEQKILLVPLARIMTMSSVHWASLWEWF-NH2	1203
1386	TALLEQAQIQQEKNEYELQKLDK	1204
1387	Ac-TALLEQAQIQQEKNEYELQKLDK-NH2	1205
1388	Ac-TALLEQAQIQQEKIEYELQKLIE-NH2	1206
1389	TALLEQAQIQQEKIEYELQKLIE	1207
1390	Ac-QARQLLSGIVQQQNNLLRAIEAQQHLLQLTVWGIKQLQARILAVERY-NH2	1208
1391	Rhod-QARQLLSGIVQQQNNLLRAIEAQQHLLQLTVWGIKQLQARILAVERY-NH2	1209
1392	Ac-GAASLTLSAQSRTLLAGIVQQQQQLLDVVKRQQEML-NH2	1210
1393	Ac-GSAMGAASLTLSAQSRTLLAGIVQQQQQLLDVVKRQQEML-NH2	1211
1394	Ac-PALSTGLIHLHQNIVDVQFLFGVGSSIASWAIKWEY-NH2	1212
1395	Ac-PALSTGLIHLHQNIVDVQFLYGVGSSIASWAIK-NH2	1213
1396	Ac-LSTTQWQVLPUSFTTLPALSTGLIHLHQMVDVQY-NH2	1214
1397	Ac-FRKFPEATFSRUGSGPRITPRUMVDFPFRLWHY-NH2	1215
1398	Ac-DFPFRLWHFPUTINYTIFKVRLFVGGVEHRLEAAUNWTWNH2♂	1216
1399	Ac-YVGGVEHRLEAAUNWTRGERUDLEDRDRSELSPL-NH2	1217
1400	MVYPSDEYDASISQVNEEINQALAYIRKADELLENV	1218
1402	Ac-GPLLVLQAGFFLLTRILTIPQSLDSWWTSLNFLGG-NH2	1220
1403	Ac-LGPLLVLQAGFFLLTRILTIPQSLDSWWTSLNFLG-NH2	1221
1404	Ac-FLGPLLVLQAGFFLLTRILTIPQSLDSWWTSLNFL-NH2	1222
1405	Ac-YTNTIYTLLEESQNQQEKNEQELLELDKWASLWNWF-NH2	1223
1406	YTNTIYTLLEESQNQQEKNEQELLELDKWASLWNWF	1357
1407	Ac-YTGIIYNLLEESQNQQEKNEQELLELDKWANLWNWF-NH2	1358
1408	YTGIIYNLLEESQNQQEKNEQELLELDKWANLWNWF	1359
1409	Ac-YTSLWSLLEKSQIQQEKNEQELLELDKWASLWNWF-NH2	1360
1410	YTSLIYSLLEKSQIQQEKNEQELLELDKWASLWNWF	1361
1411	Ac-EKSQIQQEKNEQELLELDKWA-NH2	1362
1412	EKSQIQQEKNEQELLELDKWA	1363
1413	Ac-EQAQIQQEKNEYELQKLDKWA-NH2	1364
1414	Ac-YTSLIGSLIEESQIQQERNEQELLELDRWASLWEWF-NH2	1365
1415	Ac-YTXLIHSLIXESQNQQXKNEQELXELDKWASLWNWF-NH2	1366
1416	Ac-YTXLIHSLIWESQNQQXKNEQELXELD-NH2	1367
1417	Ac-YTSLIHSHEESQNQQEKNEQELLELD-NH2	1368
1418	Ac-WQEQEXKlTALLXQAQIQQXKNEYELXKLDKWASLWEWF-NH2	1369
1419	Ac-XKITALLXQAQIQQXKNEYELXKLDKWASLWEWF-NH2	1370
1420	Ac-WQEWWXKITALLXQAQIQQXKNEYELXKLD-NH2	1371
1421	Ac-WEQKITALLEQAQIQQEKNEYELQKLD-NH2	1372
1422	Ac-WEXKITALLXQAQIQQXKNEYELXKLD-NH2	1373
1423	Ac-XKITALLXQAQIQQXKNEYELXKLD-NH2	1374
1425	Ac-QKITALLEQAQIQQEKNEYELQKLD-NH2	1375
1426	Ac-QKITALLEQAQIQQEKNEYELQKLDKWASLWEWF-NH2	1381
1427	Ac-WQEWEQKITALLEQAQIQQEKNEYELQKLD-NH2	1379
1428	Ac-VYPSDEYDASISQVNEEINQALAYIRKADELLEN-OH	1377
1429	Ac-VYPSDEYDASISQVNEEINQALAYIRKADELLE-OH	1380
1430	Ac-VYPSDEYDASISQVNEEINQALAYIRKADELL-OH	1376
1431	Ac-VYPSDEYDASISQVNEEINQALAYIRKADEL-OH	1378
1432	YPSDEYDASISQVNEEINQALAYIRKADELLENV-NH2	1227
1433	PSDEYDASISQVNEEINQALAYIRKADELLENV-NH2	1228
1434	SDEYDASISQVNEEINQALAYIRKADELLENV-NH2	1229
1435	DEYDASISQVNEEINQALAYIRKADELLENV-NH2	1230
1436	Ac-VYPSDEYDASISQVDEEINQALAYIRKADELLENV-NH2	1231
1437	Ac-VYPSDEYDASISQVNEEIDQALAYIRKADELLENV-NH2	1232
1438	Ac-VYPSDEYDASISQVNEEINQALAYIRKADELLEDV-NH2	1233
1439	Ac-VYPSDEYDASISQVDEEIDQALAYIRKADELLENV-NH2	1234
1440	Ac-LLSTNKAVVLSLNGVSVLTSKVLDLKNYIDKQLLP-NH2	1235
1441	Ac-LSTNKAVVSLSNGVSVLTSKVLDLKNYIDKQLLPI-NH2	1236
1442	Ac-STNKAVVSLSNGVSVGTSKVLDLKNYIDKQLLPIV-NH2	1382
1443	Ac-TNKAVVSLSNGVSVLTSKVLDLKNYIDKQLLPIVN-NH2	1383
1444	Ac-NKAVVSLSNGVSVLTSKVLDLKNYIDKQLLPIVNK-NH2	1384
1445	Ac-KAVVSLSNGVSVLTSKVLDLKNYIDKQLLPIVNKQ-NH2	1385
1446	Ac-AVVSLSNGVSVLTSKVLDLKNYIDKQLLPIVNKQS-NH2	1386
1447	Ac-VVSLSNGVSVLTSKVDLKNYIDKQWLLPIVNKQSU-NH2	1387
1448	Ac-VSLSNGVSVLTSKVLDLKNYIDKQLLPIVNKQSUS-NH2	1388
1449	Ac-SLSNGVSVLTSKVLDLKNYIDKQLLPIVNKQSUSI-NH2	1389
1450	Ac-LSNGVSVLTSKVLDKLKNYIDKQLLPIVNKQSUSIS-NH2	1390
1451	Ac-SNGVSVLTSKVLDLKNYIDKQLLPIVNKQSUSISN-NH2	1391
1452	Ac-NGVSVLTSKVLDLKNYIDKQLLPIVNKQSUSISNI-NH2	1392
1453	Ac-GVSVLTSKVLDLKNYIDKQLLPIVNKQSUSISNIE-NH2	1393
1454	Ac-VSVLTSKVLDLKNYIDKQLLPIVNKQSUSISINIET-NH2	1394
1455	Ac-SVLTSKVLDLKNYIDKQLLPIVNKQSUSISNIETV-NH2	1395
1456	Ac-VLTSKVLDLKNYIDKQLLPIVNKQSUSISNIETVI-NH2	1396
1457	Ac-LTSKVLDLKNYIDKQLLPIVNKQSUSISNIETVIE-NH2	1397
1458	Ac-TSKVLDLKNYIDKQLLPIVKQSUSISNIETVIEF-NH2	1398
1459	Ac-SKVLDLKNYIDKQLLPIVNKQSUSISNIETVIEFQ-NH2	1399
1460	Ac-KVLDLKNYIDKQLLPIVNKQSUSISNIETVIEFQQ-NH2	1400
1461	Ac-VLDLKNYIDKQLLPIVNKQSUSISNIETVIEFQQK-NH2	1401
1462	Ac-LDLKNYIDKQLLPIVNKQSUSISNIETVIEFQQKN-NH2	1402
1463	Ac-DLKYNYIDKQLLPIVNKQSUSISNIETVIEFQQKNN-NH2	1403
1464	Ac-LKNYIDKQLLPIVNKQSUSISNIETVIEFQQKNNR-NH2	1404
1465	Ac-KNYIDKQLLPIVNKQSUSISNIETVIEFQQKNNRL-NH2	1405
1466	Ac-NYIDKQLLPIVNKQSUSISNIETVIEFQQKNNRLL-NH2	1406
1467	Ac-YIDKQLLPIVNKQSUSISNIETVIEFQQKNNRLLE-NH2	1407
1468	Ac-IDKQLLPIVNKQSUSISNIETVIEFQQKNNRLLEI-NH2	1408
1469	Ac-DKQLLPIVNKQSUSISNIETVIEFQQKNNRLLEIT-NH2	1409
1470	Ac-KQLLPIVNKQSUSISNIETVIEFQQKNNRLLEITR-NH2	1410
1471	Ac-QLLPIVNKQSUSISNIETVIEFQQKNNRLLEITRE-NH2	1411
1472	Ac-VYPSDEYDASISQVNEEINQALA	1412
1473	QVNEEINQALAYIRKADELLENV-NH2	1413
1474	VYPSDEYDASISQVNEEINQALAYIRKADELLENV	1414
1475	Ac-DEYDASISQVNEEINQALAYIREADEL-NH2	1415
1476	Ac-DEYDASISQVNEKINQALAYIREADEL-NH2	1416
1477	Ac-DDECLNSVKNGTYDFPKFEEESKLNRNEIKGVKLS-NH2	1417
1478	Ac-DDE-Abu-LNSVKNGTYDFPKFEEESKLNRNEIKGVKLS-NH2	1718
1479	Ac-YHKCDDECLNSVKNGTFDFPKFEEESKLNRNEIKGVKLSS-NH2	1719
1480	Ac-YHK-Abu-DDE-Abu-LNSVKNGTFDFPKFEEESKLNRNEIKGVKLSS-NH2	1420
1481	Ac-YTSLIHSLIEESQIQQEKNEQELLELDKWASLWNWF-NH2	1344
1482	Ac-YTSLIHSLIEESQNQQEKNEYELLELDKWASLWNWF-NH2	1345
1483	Ac-YTSLIHSLIEESQIQQEKNEYELLELDKWASLWNWF-NH2	1346
1484	Ac-YTSLIHSLIEESQIQQEKNEYELQKLDKWASLWNWF-NH2	1347
1485	Ac-YTSLIHSLIEESQNQQEKNEQELQKLDKWASLWNWF-NH2	1348
1486	Ac-YTSLIHSLIEESQNQQEKNEYELQKLDKWASLWNWF-NH2	1421
1487	Ac-YTSHHSLIEESQIQQEKNEQELQKLDKWASLWNWF-NH2	1422
1488	Ac-YTSLIHSLIEESQNQQEKNEQELLELDKWASLWEWF-NH2	1423
1489	Ac-YTSuHSLIEESQIQQEKNEQELLELDKWASLWEWF-NH2	1424
1490	Ac-YTSLIHSuEESQNQQEKNEYELLELDKWASLWEWF-NH2	1425
1491	Ac-YTSHHSLIEESQIQQEKNEYELLELDKWASLWEWF-NH2	1426
1492	Ac-YTSLIHSLIEESQIQQEKNEYELQKLDKWASLWEWF-NH2	1427
1493	Ac-YTSLIHSLIEESQNQQEKNEQELQKLDKWASLWEWF-NH2	1428
1494	Ac-YTSLIHSLIEESQNQQEKNEYELQKLDKWASLWEWF-NH2	1429
1495	Ac-YTSLIHSLIEESQIQQEKNEQELQKLDKWASLWEWF-NH2	1430
1496	Ac-WQEQEQKITALLEQAQIQQEKNEYELQKLDKEWWF-NH2	1431
1497	Ac-WQEWEQKITALLEQAQIQQEKNEYELQKLIEWASLWEWF-NH2	1432
1498	Ac-WQEWEQKITALLEQAQIQQEKNEYELQKLAKWASLWEWF-NH2	1256
1499	Ac-WQEWEQKITALLEQAQIQQEKNEYELQKLIKWASLWEWF-NH2	1257
1500	Ac-WQEWEQKITALLEQAQIQQEKNEYELQKLIEWAGLWEWF-NH2	1258
1501	Ac-WQEWEQKITALLEQAQIQQEKNEYELQKLAKWAGLWEWF-NH2	1259
1502	Ac-WQEWEQKITALLEQAQIQQEKNEYELQKLIKWAGLWEWF-NH2	1260
1503	Ac-WQEWEQKITALLEQAQIQQEKNEYELQKLIEWAGLWAWF-NH2	1261
1504	Ac-WQEWEQKITALLEQAQIQQEKNEYELQKLAKWAGLWAWF-NH2	1262
1505	Ac-WQEWEQKITALLEQAQIQQEKNEYELQKLIKWAGLWAWF-NH2	1263
1506	Ac-WQEWEQKITALLEQAQIQQEKGEYELQKLDKQEQF-NH2	1264
1507	Ac-WQEWEQKITALLEQAQIQQEKGEYELLELDKWEWF-NH2	1265
1508	Ac-WQEWEQKITALLEQAQIQQEKGEYELQKLAKWEWF-NH2	1266
1509	Ac-WQEWEQKITALLEQAQIQQEKGEYELQKLDWQWEF-NH2	1267
1510	Ac-WQEWEQKITALLEQAQIQQEKGEYELLELAKWEWF-NH2	1268
1511	Ac-WEQWEQKITALLEQAQIQQEKNEYELLELDKWEWF-NH2	1269
1512	Ac-WQEWEQKITALLEQAQIQQEKNEYELEEEHEWASLWEWF-NH2	1270
1513	Ac-WQEWEQKITALLEQAQIQQEKNEYELLEuEWAGLWEWF-NH2	1271
1514	Ac-WQEWEQKITALLEQAQIQQEKNEYELLELIEWAGLWAWF-NH2	1272
1515	Ac-WQEWEREITALLEQAQIQQEKNEYELQKLIEWASLWEWF-NH2	1273
1516	Ac-WQEWEREIQQEKNEYELQKLDKWASLWEWF-NH2	1274
1517	Ac-WQEWEREIQQEKGEYELQKLIEWEWF-NH2	1275
1518	Ac-WQEWQAQIQQEKNEYELQKLDKWASLWEWF-NH2	1276
1519	Ac-WQEWQAQIQQEKGEYELQKLIEWEWF-NH2	1277

1515 1 19 PRT Artificial Sequence Core polypeptide 1Gly Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr Leu 1 5 10 15Lys Asp Gln 2 19 PRT Artificial Sequence Core polypeptide 2Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu 1 5 10 15Thr Val Trp 3 18 PRT Artificial Sequence Core polypeptide 3Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn 1 5 10 15Trp Phe 4 18 PRT Artificial Sequence Core polypeptide 4Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys 5 28 PRT Artificial Sequence Core polypeptide 5Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala Val Glu Arg 1 5 10 15Tyr Leu Lys Asp Gln Gln Leu Leu Gly Ile Trp Gly 20 25 6 28 PRT Artificial Sequence Core polypeptide 6Gln His Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala 1 5 10 15Arg Ile Leu Ala Val Glu Arg Tyr Leu Lys Asp Gln 20 25 7 28 PRT Artificial Sequence Core polypeptide 7Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp 1 5 10 15Gly Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala Val 20 25 8 28 PRT Artificial Sequence Core polypeptide 8Val Gln Gln Gln Asn Asn Leu Leu Ala Arg Ile Glu Ala Gln Gln His 1 5 10 15Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu 20 25 9 28 PRT Artificial Sequence Core polypeptide 9Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu Leu Arg 1 5 10 15Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr 20 25 10 28 PRT Artificial Sequence Core polypeptide 10Met Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln 1 5 10 15Gln Gln Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln 20 25 11 27 PRT Artificial Sequence Core polypeptide 11Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Ser Lys Val Leu 1 5 10 15Asp Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu 20 25 12 28 PRT Artificial Sequence Core polypeptide 12Leu Leu Ser Thr Asn Lys Ala Val Val Ser Leu Ser Asn Gly Val Ser 1 5 10 15Val Leu Thr Ser Lys Val Leu Asp Leu Lys Asn Tyr 20 25 13 28 PRT Artificial Sequence Core polypeptide 13Val Leu His Leu Glu Gly Glu Val Asn Lys Ile Lys Ser Ala Leu Leu 1 5 10 15Ser Thr Asn Lys Ala Val Val Ser Leu Ser Asn Gly 20 25 14 28 PRT Artificial Sequence Core polypeptide 14Leu Leu Ser Thr Asn Lys Ala Val Val Ser Leu Ser Asn Gly Val Ser 1 5 10 15Val Leu Thr Ser Lys Val Leu Asp Leu Lys Asn Tyr 20 25 15 36 PRT Artificial Sequence Core polypeptide 15Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Asn Trp Phe 35 16 38 PRT Artificial Sequence Core polypeptide 16Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu 1 5 10 15Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala Val Glu 20 25 30Arg Tyr Leu Lys Asp Gln 35 17 42 PRT Artificial Sequence Core polypeptide 17Ile Glu Leu Ser Asn Ile Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala 1 5 10 15Lys Val Lys Leu Ile Lys Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val 20 25 30Thr Glu Leu Gln Leu Leu Met Gln Ser Thr 35 40 18 28 PRT Artificial Sequence Core polypeptide 18Ile Glu Leu Ser Asn Ile Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala 1 5 10 15Lys Val Lys Leu Ile Lys Gln Glu Leu Asp Lys Tyr 20 25 19 28 PRT Artificial Sequence Core polypeptide 19Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys Gln 1 5 10 15Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu 20 25 20 28 PRT Artificial Sequence Core polypeptide 20Asp Ala Lys Val Lys Leu Ile Lys Gln Glu Leu Asp Lys Tyr Lys Asn 1 5 10 15Ala Val Thr Glu Leu Gln Leu Leu Met Gln Ser Thr 20 25 21 28 PRT Artificial Sequence Core polypeptide 21Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys Gln Glu Leu Asp 1 5 10 15Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 20 25 22 35 PRT Artificial Sequence Core polypeptide 22Ser Asn Ile Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys 1 5 10 15Leu Ile Lys Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu 20 25 30Gln Leu Leu 35 23 37 PRT Artificial Sequence Core polypeptide 23Ala Ser Gly Val Ala Val Ser Lys Val Leu His Leu Glu Gly Glu Val 1 5 10 15Asn Lys Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys Ala Val Val Ser 20 25 30Leu Ser Asn Gly Val 35 24 35 PRT Artificial Sequence Core polypeptide 24Ser Gly Val Ala Val Ser Lys Val Leu His Leu Glu Gly Glu Val Asn 1 5 10 15Lys Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys Ala Val Val Ser Leu 20 25 30Ser Asn Gly 35 25 35 PRT Artificial Sequence Core polypeptide 25Val Leu His Leu Glu Gly Glu Val Asn Lys Ile Lys Ser Ala Leu Leu 1 5 10 15Ser Thr His Lys Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu 20 25 30Thr Ser Lys 35 26 36 PRT Artificial Sequence Core polypeptide 26Ala Arg Lys Leu Gln Arg Met Lys Gln Leu Glu Asp Lys Val Glu Glu 1 5 10 15Leu Leu Ser Lys Asn Tyr His Tyr Leu Glu Asn Glu Val Ala Arg Leu 20 25 30Lys Lys Leu Val 35 27 34 PRT Artificial Sequence Core polypeptide 27Arg Met Lys Gln Leu Glu Asp Lys Val Glu Glu Leu Leu Ser Lys Asn 1 5 10 15Tyr His Tyr Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Leu Val Gly 20 25 30Glu Arg 28 28 PRT Artificial Sequence Core polypeptide 28Val Gln Gln Gln Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His 1 5 10 15Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu 20 25 29 28 PRT Artificial Sequence Core polypeptide 29Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp 1 5 10 15Gly Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala Val 20 25 30 28 PRT Artificial Sequence Core polypeptide 30Gln His Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala 1 5 10 15Arg Ile Leu Ala Val Glu Arg Tyr Leu Lys Asp Gln 20 25 31 28 PRT Artificial Sequence Core polypeptide 31Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu Leu Arg 1 5 10 15Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr 20 25 32 28 PRT Artificial Sequence Core polypeptide 32Met Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln 1 5 10 15Gln Gln Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln 20 25 33 28 PRT Artificial Sequence Core polypeptide 33Ala Lys Gln Ala Arg Ser Asp Ile Glu Lys Leu Lys Glu Ala Ile Arg 1 5 10 15Asp Thr Asn Lys Ala Val Gln Ser Val Gln Ser Ser 20 25 34 35 PRT Artificial Sequence Core polypeptide 34Ala Ala Val Ala Leu Val Glu Ala Lys Gln Ala Arg Ser Asp Ile Glu 1 5 10 15Lys Leu Lys Glu Ala Ile Arg Asp Thr Asn Lys Ala Val Gln Ser Val 20 25 30Gln Ser Ser 35 35 35 PRT Artificial Sequence Core polypeptide 35Ala Lys Gln Ala Arg Ser Asp Ile Glu Lys Leu Lys Glu Ala Ile Arg 1 5 10 15Asp Thr Asn Lys Ala Val Gln Ser Val Gln Ser Ser Ile Gly Asn Leu 20 25 30Ile Val Ala 35 36 28 PRT Artificial Sequence Core polypeptide 36Gly Thr Ile Ala Leu Gly Val Ala Thr Ser Ala Gln Ile Thr Ala Ala 1 5 10 15Val Ala Leu Val Glu Ala Lys Gln Ala Arg Ser Asp 20 25 37 28 PRT Artificial Sequence Core polypeptide 37Ala Thr Ser Ala Gln Ile Thr Ala Ala Val Ala Leu Val Glu Ala Lys 1 5 10 15Gln Ala Arg Ser Asp Ile Glu Lys Leu Lys Glu Ala 20 25 38 28 PRT Artificial Sequence Core polypeptide 38Ala Ala Val Ala Leu Val Glu Ala Lys Gln Ala Arg Ser Asp Ile Glu 1 5 10 15Lys Leu Lys Glu Ala Ile Arg Asp Thr Asn Lys Ala 20 25 39 35 PRT Artificial Sequence Core polypeptide 39Ile Asp Ile Ser Ile Glu Leu Asn Lys Ala Lys Ser Asp Leu Glu Glu 1 5 10 15Ser Lys Glu Trp Ile Glu Lys Ser Asn Gln Glu Leu Asp Ser Ile Gly 20 25 30Asn Trp Glu 35 40 28 PRT Artificial Sequence Core polypeptide 40Ile Glu Lys Leu Lys Glu Ala Ile Arg Asp Thr Asn Lys Ala Val Gln 1 5 10 15Ser Val Gln Ser Ser Ile Gly Asn Leu Ile Val Ala 20 25 41 28 PRT Artificial Sequence Core polypeptide 41Ile Arg Asp Thr Asn Lys Ala Val Gln Ser Val Gln Ser Ser Ile Gly 1 5 10 15Asn Leu Ile Val Ala Ile Lys Ser Val Gln Asp Tyr 20 25 42 28 PRT Artificial Sequence Core polypeptide 42Ala Val Gln Ser Val Gln Ser Ser Ile Gly Asn Leu Ile Val Ala Ile 1 5 10 15Lys Ser Val Gln Asp Tyr Val Asn Lys Glu Ile Val 20 25 43 50 PRT Artificial Sequence Core polypeptide 43Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu 1 5 10 15Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp 20 25 30Gly Ile Lys Gln Leu Ala Arg Ile Leu Ala Val Glu Arg Tyr Leu Lys 35 40 45Asp Gln 50 44 28 PRT Artificial Sequence Core polypeptide 44Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu 1 5 10 15Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln 20 25 45 48 PRT Artificial Sequence Core polypeptide 45Met Thr Trp Met Glu Met Asp Arg Glu Ile Asn Asn Tyr Thr Ser Leu 1 5 10 15Ile Gly Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu 20 25 30Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe 35 40 45 46 35 PRT Artificial Sequence Core polypeptide 46Trp Met Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser Leu Ile Gly 1 5 10 15Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu 20 25 30Leu Leu Glu 35 47 28 PRT Artificial Sequence Core polypeptide 47Ile Asn Asn Tyr Thr Ser Leu Ile Gly Ser Leu Ile Glu Glu Ser Gln 1 5 10 15Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu 20 25 48 35 PRT Artificial Sequence Core polypeptide 48Ile Asn Asn Tyr Thr Ser Leu Ile Gly Ser Leu Ile Glu Glu Ser Gln 1 5 10 15Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp 20 25 30Ala Ser Leu 35 49 33 PRT Artificial Sequence Core polypeptide 49Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser Leu Ile Gly Ser Leu 1 5 10 15Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Gly Gly 20 25 30Cys 50 28 PRT Artificial Sequence Core polypeptide 50Gln Ser Arg Thr Leu Leu Ala Gly Ile Val Gln Gln Gln Gln Gln Leu 1 5 10 15Leu Asp Val Val Lys Arg Gln Gln Glu Leu Leu Arg 20 25 51 44 PRT Artificial Sequence Core polypeptide 51Asn Asn Asp Thr Trp Gln Glu Trp Glu Arg Lys Val Asp Phe Leu Glu 1 5 10 15Glu Asn Ile Thr Ala Leu Leu Glu Glu Ala Gln Ile Gln Gln Glu Lys 20 25 30Asn Met Tyr Glu Leu Gln Lys Leu Asn Ser Trp Asp 35 40 52 28 PRT Artificial Sequence Core polypeptide 52Trp Gln Glu Trp Glu Arg Lys Val Asp Phe Leu Glu Glu Asn Ile Thr 1 5 10 15Ala Leu Leu Glu Glu Ala Gln Ile Gln Gln Glu Lys 20 25 53 28 PRT Artificial Sequence Core polypeptide 53Val Asp Phe Leu Glu Glu Asn Ile Thr Ala Leu Leu Glu Glu Ala Gln 1 5 10 15Ile Gln Gln Glu Lys Asn Met Tyr Glu Leu Gln Lys 20 25 54 28 PRT Artificial Sequence Core polypeptide 54Ile Thr Ala Leu Leu Glu Glu Ala Gln Ile Gln Gln Glu Lys Asn Met 1 5 10 15Tyr Glu Leu Gln Lys Leu Asn Ser Trp Asp Val Phe 20 25 55 36 PRT Artificial Sequence Core polypeptide 55Ser Ser Glu Ser Phe Thr Leu Leu Glu Gln Trp Asn Asn Trp Lys Leu 1 5 10 15Gln Leu Ala Glu Gln Trp Leu Glu Gln Ile Asn Glu Lys His Tyr Leu 20 25 30Glu Asp Ile Ser 35 56 10 PRT Artificial Sequence Core polypeptide 56Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe 1 5 10 57 18 PRT Artificial Sequence Core polypeptide 57Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn 1 5 10 15Trp Phe 58 20 PRT Artificial Sequence Core polypeptide 58Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 1 5 10 15Trp Asn Trp Phe 20 59 23 PRT Artificial Sequence Core polypeptide 59Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp 1 5 10 15Ala Ser Leu Trp Asn Trp Phe 20 60 26 PRT Artificial Sequence Core polypeptide 60Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu 1 5 10 15Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe 20 25 61 33 PRT Artificial Sequence Core polypeptide 61Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn 1 5 10 15Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp 20 25 30Phe 62 28 PRT Artificial Sequence Core polypeptide 62Asn Asp Gln Lys Lys Leu Met Ser Asn Asn Val Gln Ile Val Arg Gln 1 5 10 15Gln Ser Tyr Ser Ile Met Ser Ile Ile Lys Glu Glu 20 25 63 28 PRT Artificial Sequence Core polypeptide 63Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln 1 5 10 15Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu 20 25 64 27 PRT Artificial Sequence Core polypeptide 64Val Ser Lys Gly Tyr Ser Ala Leu Arg Thr Gly Trp Tyr Thr Ser Val 1 5 10 15Ile Thr Ile Glu Leu Ser Asn Ile Lys Glu Asn 20 25 65 27 PRT Artificial Sequence Core polypeptide 65Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Ser Lys Val Leu 1 5 10 15Asp Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu 20 25 66 28 PRT Artificial Sequence Core polypeptide 66Val Asn Lys Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys Ala Val Val 1 5 10 15Ser Leu Ser Asn Gly Val Ser Val Leu Thr Ser Lys 20 25 67 35 PRT Artificial Sequence Core polypeptide 67Pro Ile Ile Asn Phe Tyr Asp Pro Leu Val Phe Pro Ser Asp Glu Phe 1 5 10 15Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser Leu Ala 20 25 30Phe Ile Arg 35 68 28 PRT Artificial Sequence Core polypeptide 68Asn Leu Val Tyr Ala Gln Leu Gln Phe Thr Tyr Asp Thr Leu Arg Gly 1 5 10 15Tyr Ile Asn Arg Ala Leu Ala Gln Ile Ala Glu Ala 20 25 69 31 PRT Artificial Sequence Core polypeptide 69Leu Asn Gln Val Asp Leu Thr Glu Thr Leu Glu Arg Tyr Gln Gln Arg 1 5 10 15Leu Asn Thr Tyr Ala Leu Val Ser Lys Asp Ala Ser Tyr Arg Ser 20 25 30 70 27 PRT Artificial Sequence Core polypeptide 70Glu Leu Leu Val Leu Lys Lys Ala Gln Leu Asn Arg His Ser Tyr Leu 1 5 10 15Lys Asp Ser Asp Phe Leu Asp Ala Ala Leu Asp 20 25 71 27 PRT Artificial Sequence Core polypeptide 71Leu Ala Glu Ala Gly Glu Glu Ser Val Thr Glu Asp Thr Glu Arg Glu 1 5 10 15Asp Thr Glu Glu Glu Arg Glu Asp Glu Glu Glu 20 25 72 35 PRT Artificial Sequence Core polypeptide 72Ala Leu Leu Ala Glu Ala Gly Glu Glu Ser Val Thr Glu Asp Thr Glu 1 5 10 15Arg Glu Asp Thr Glu Glu Glu Arg Glu Asp Glu Glu Glu Glu Asn Glu 20 25 30Ala Arg Thr 35 73 35 PRT Artificial Sequence Core polypeptide 73Glu Thr Glu Arg Ser Val Asp Leu Val Ala Ala Leu Leu Ala Glu Ala 1 5 10 15Gly Glu Glu Ser Val Thr Glu Asp Thr Glu Arg Glu Asp Thr Glu Glu 20 25 30Glu Arg Glu 35 74 28 PRT Artificial Sequence Core polypeptide 74Glu Glu Ser Val Thr Glu Asp Thr Glu Arg Glu Asp Thr Glu Glu Glu 1 5 10 15Arg Glu Asp Glu Glu Glu Glu Asn Glu Ala Arg Thr 20 25 75 28 PRT Artificial Sequence Core polypeptide 75Val Asp Leu Val Ala Ala Leu Leu Ala Glu Ala Gly Glu Glu Ser Val 1 5 10 15Thr Glu Asp Thr Glu Arg Glu Asp Thr Glu Glu Glu 20 25 76 25 PRT Artificial Sequence Core polypeptide 76Asn Ser Glu Thr Glu Arg Ser Val Asp Leu Val Ala Ala Leu Leu Ala 1 5 10 15Glu Ala Gly Glu Glu Ser Val Thr Glu 20 25 77 28 PRT Artificial Sequence Core polypeptide 77Asp Ile Ser Tyr Ala Gln Leu Gln Phe Thr Tyr Asp Val Leu Lys Asp 1 5 10 15Tyr Ile Asn Asp Ala Leu Arg Asn Ile Met Asp Ala 20 25 78 30 PRT Artificial Sequence Core polypeptide 78Ser Asn Val Phe Ser Lys Asp Glu Ile Met Arg Glu Tyr Asn Ser Gln 1 5 10 15Lys Gln His Ile Arg Thr Leu Ser Ala Lys Val Asn Asp Asn 20 25 30 79 35 PRT Artificial Sequence Core polypeptide 79Ile Asp Ile Ser Ile Glu Leu Asn Lys Ala Lys Ser Asp Leu Glu Glu 1 5 10 15Ala Lys Glu Trp Ile Lys Lys Ala Asn Gln Lys Leu Asp Ser Ile Gly 20 25 30Asn Trp His 35 80 35 PRT Artificial Sequence Core polypeptide 80Ile Asp Ile Ser Ile Glu Leu Asn Lys Ala Lys Ser Asp Leu Glu Glu 1 5 10 15Ser Lys Glu Trp Ile Lys Lys Ala Asn Gln Lys Leu Asp Ser Ile Gly 20 25 30Asn Trp His 35 81 39 PRT Artificial Sequence Core polypeptide 81Tyr Glu Ser Thr Gln Lys Ala Phe Asp Gly Ile Thr Asn Lys Val Asn 1 5 10 15Ser Val Ile Glu Lys Thr Asn Thr Gln Phe Glu Ala Val Gly Lys Glu 20 25 30Phe Gly Asn Leu Glu Lys Arg 35 82 28 PRT Artificial Sequence Core polypeptide 82Asp Glu Tyr Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln 1 5 10 15Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu 20 25 83 38 PRT Artificial Sequence Core polypeptide 83Val Leu His Gln Leu Asn Ile Gln Leu Lys Gln Tyr Leu Glu Thr Gln 1 5 10 15Glu Arg Leu Leu Ala Gly Asn Arg Ile Ala Ala Arg Gln Leu Leu Gln 20 25 30Ile Trp Lys Asp Val Ala 35 84 38 PRT Artificial Sequence Core polypeptide 84Leu Trp His Glu Gln Leu Leu Asn Thr Ala Gln Arg Ala Gly Leu Gln 1 5 10 15Leu Gln Leu Ile Asn Gln Ala Leu Ala Val Arg Glu Lys Val Leu Ile 20 25 30Arg Tyr Asp Ile Gln Lys 35 85 35 PRT Artificial Sequence Core polypeptide 85Leu Leu Asp Asn Phe Glu Ser Thr Trp Glu Gln Ser Lys Glu Leu Trp 1 5 10 15Glu Gln Gln Glu Ile Ser Ile Gln Asn Leu His Lys Ser Ala Leu Gln 20 25 30Glu Tyr Trp 35 86 36 PRT Artificial Sequence Core polypeptide 86Leu Ser Asn Leu Leu Gln Ile Ser Asn Asn Ser Asp Glu Trp Leu Glu 1 5 10 15Ala Leu Glu Ile Glu His Glu Lys Trp Lys Leu Thr Gln Trp Gln Ser 20 25 30Tyr Glu Gln Phe 35 87 36 PRT Artificial Sequence Core polypeptide 87Lys Leu Glu Ala Leu Glu Gly Lys Leu Glu Ala Leu Glu Gly Lys Leu 1 5 10 15Glu Ala Leu Glu Gly Lys Leu Glu Ala Leu Glu Gly Lys Leu Glu Ala 20 25 30Leu Glu Gly Lys 35 88 29 PRT Artificial Sequence Core polypeptide 88Glu Leu Arg Ala Leu Arg Gly Glu Leu Arg Ala Leu Arg Gly Glu Leu 1 5 10 15Arg Ala Leu Arg Gly Glu Leu Arg Ala Leu Arg Gly Lys 20 25 89 36 PRT Artificial Sequence Core polypeptide 89Glu Leu Lys Ala Lys Glu Leu Glu Gly Glu Gly Leu Ala Glu Gly Glu 1 5 10 15Glu Ala Leu Lys Gly Leu Leu Glu Lys Ala Ala Lys Leu Glu Gly Leu 20 25 30Glu Leu Leu Lys 35 90 33 PRT Artificial Sequence Core polypeptide 90Met Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser Leu Ile His Ser 1 5 10 15Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu 20 25 30Leu 91 36 PRT Artificial Sequence Core polypeptide 91Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Asn Ala Phe 35 92 36 PRT Artificial Sequence Core polypeptide 92Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Ala Asn Trp Phe 35 93 36 PRT Artificial Sequence Core polypeptide 93Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Gln Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Asn Trp Phe 35 94 36 PRT Artificial Sequence Core polypeptide 94Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Gln Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Asn Trp Phe 35 95 36 PRT Artificial Sequence Core polypeptide 95Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Gln Gln Glu Leu Leu Gln Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Asn Trp Phe 35 96 33 PRT Artificial Sequence Core polypeptide 96Arg Met Lys Gln Leu Glu Asp Lys Val Glu Glu Leu Leu Ser Lys Asn 1 5 10 15Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Leu Val Gly Glu 20 25 30Arg 97 28 PRT Artificial Sequence Core polypeptide 97Gln Gln Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala 1 5 10 15Arg Ile Leu Ala Val Glu Arg Tyr Leu Lys Asn Gln 20 25 98 18 PRT Artificial Sequence Core polypeptide 98Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn 1 5 10 15Trp Phe 99 36 PRT Artificial Sequence Core polypeptide 99Tyr Thr Ser Leu Ile Gln Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Asn Trp Phe 35 100 35 PRT Artificial Sequence Core polypeptide 100Ile Ile Asn Phe Tyr Asp Pro Leu Val Phe Pro Ser Asp Glu Phe Asp 1 5 10 15Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser Leu Ala Phe 20 25 30Ile Arg Lys 35 101 35 PRT Artificial Sequence Core polypeptide 101Ile Asn Phe Tyr Asp Pro Leu Val Phe Pro Ser Asp Glu Phe Asp Ala 1 5 10 15Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile 20 25 30Arg Lys Ser 35 102 35 PRT Artificial Sequence Core polypeptide 102Asn Phe Tyr Asp Pro Leu Val Phe Pro Ser Asp Glu Phe Asp Ala Ser 1 5 10 15Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg 20 25 30Lys Ser Asp 35 103 35 PRT Artificial Sequence Core polypeptide 103Phe Tyr Asp Pro Leu Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile 1 5 10 15Ser Gln Val Asn Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys 20 25 30Ser Asp Glu 35 104 35 PRT Artificial Sequence Core polypeptide 104Tyr Asp Pro Leu Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser 1 5 10 15Gln Val Asn Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser 20 25 30Asp Glu Leu 35 105 35 PRT Artificial Sequence Core polypeptide 105Asp Pro Leu Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln 1 5 10 15Val Asn Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp 20 25 30Glu Leu Leu 35 106 35 PRT Artificial Sequence Core polypeptide 106Pro Leu Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val 1 5 10 15Asn Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu 20 25 30Leu Leu His 35 107 35 PRT Artificial Sequence Core polypeptide 107Leu Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn 1 5 10 15Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu 20 25 30Leu His Asn 35 108 35 PRT Artificial Sequence Core polypeptide 108Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn Glu 1 5 10 15Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu 20 25 30His Asn Val 35 109 35 PRT Artificial Sequence Core polypeptide 109Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn Glu Lys 1 5 10 15Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu His 20 25 30Asn Val Asn 35 110 35 PRT Artificial Sequence Core polypeptide 110Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile 1 5 10 15Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu His Asn 20 25 30Val Asn Ala 35 111 35 PRT Artificial Sequence Core polypeptide 111Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn 1 5 10 15Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu His Asn Val 20 25 30Asn Ala Gly 35 112 35 PRT Artificial Sequence Core polypeptide 112Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln 1 5 10 15Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu His Asn Val Asn 20 25 30Ala Gly Lys 35 113 35 PRT Artificial Sequence Core polypeptide 113Glu Phe Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser 1 5 10 15Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu His Asn Val Asn Ala 20 25 30Gly Lys Ser 35 114 35 PRT Artificial Sequence Core polypeptide 114Phe Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser Leu 1 5 10 15Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu His Asn Val Asn Ala Gly 20 25 30Lys Ser Thr 35 115 35 PRT Artificial Sequence Core polypeptide 115Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser Leu Ala 1 5 10 15Phe Ile Arg Lys Ser Asp Glu Leu Leu His Asn Val Asn Ala Gly Lys 20 25 30Ser Thr Thr 35 116 35 PRT Artificial Sequence Core polypeptide 116Ala Ser Gly Val Ala Val Ser Lys Val Leu His Leu Glu Gly Glu Val 1 5 10 15Asn Lys Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys Ala Val Val Ser 20 25 30Leu Ser Asn 35 117 35 PRT Artificial Sequence Core polypeptide 117Ser Gly Val Ala Val Ser Lys Val Leu His Leu Glu Gly Glu Val Asn 1 5 10 15Lys Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys Ala Val Val Ser Leu 20 25 30Ser Asn Gly 35 118 35 PRT Artificial Sequence Core polypeptide 118Gly Val Ala Val Ser Lys Val Leu His Leu Glu Gly Glu Val Asn Lys 1 5 10 15Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys Ala Val Val Ser Leu Ser 20 25 30Asn Gly Val 35 119 35 PRT Artificial Sequence Core polypeptide 119Val Ala Val Ser Lys Val Leu His Leu Glu Gly Glu Val Asn Lys Ile 1 5 10 15Lys Ser Ala Leu Leu Ser Thr Asn Lys Ala Val Val Ser Leu Ser Asn 20 25 30Gly Val Ser 35 120 35 PRT Artificial Sequence Core polypeptide 120Ala Val Ser Lys Val Leu His Leu Glu Gly Glu Val Asn Lys Ile Lys 1 5 10 15Ser Ala Leu Leu Ser Thr Asn Lys Ala Val Val Ser Leu Ser Asn Gly 20 25 30Val Ser Val 35 121 35 PRT Artificial Sequence Core polypeptide 121Val Ser Lys Val Leu His Leu Glu Gly Glu Val Asn Lys Ile Lys Ser 1 5 10 15Ala Leu Leu Ser Thr Asn Lys Ala Val Val Ser Leu Ser Asn Gly Val 20 25 30Ser Val Leu 35 122 35 PRT Artificial Sequence Core polypeptide 122Ser Lys Val Leu His Leu Glu Gly Glu Val Asn Lys Ile Lys Ser Ala 1 5 10 15Leu Leu Ser Thr Asn Lys Ala Val Val Ser Leu Ser Asn Gly Val Ser 20 25 30Val Leu Thr 35 123 35 PRT Artificial Sequence Core polypeptide 123Lys Val Leu His Leu Glu Gly Glu Val Asn Lys Ile Lys Ser Ala Leu 1 5 10 15Leu Ser Thr Asn Lys Ala Val Val Ser Leu Ser Asn Gly Val Ser Val 20 25 30Leu Thr Ser 35 124 35 PRT Artificial Sequence Core polypeptide 124Val Leu His Leu Glu Gly Glu Val Asn Lys Ile Lys Ser Ala Leu Leu 1 5 10 15Ser Thr Asn Lys Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu 20 25 30Thr Ser Lys 35 125 35 PRT Artificial Sequence Core polypeptide 125Leu His Leu Glu Gly Glu Val Asn Lys Ile Lys Ser Ala Leu Leu Ser 1 5 10 15Thr Asn Lys Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr 20 25 30Ser Lys Val 35 126 35 PRT Artificial Sequence Core polypeptide 126His Leu Glu Gly Glu Val Asn Lys Ile Lys Ser Ala Leu Leu Ser Thr 1 5 10 15Asn Lys Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Ser 20 25 30Lys Val Leu 35 127 35 PRT Artificial Sequence Core polypeptide 127Leu Glu Gly Glu Val Asn Lys Ile Lys Ser Ala Leu Leu Ser Thr Asn 1 5 10 15Lys Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Ser Lys 20 25 30Val Leu Asp 35 128 35 PRT Artificial Sequence Core polypeptide 128Glu Gly Glu Val Asn Lys Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys 1 5 10 15Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Ser Lys Val 20 25 30Leu Asp Leu 35 129 35 PRT Artificial Sequence Core polypeptide 129Gly Glu Val Asn Lys Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys Ala 1 5 10 15Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Ser Lys Val Leu 20 25 30Asp Leu Lys 35 130 35 PRT Artificial Sequence Core polypeptide 130Glu Val Asn Lys Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys Ala Val 1 5 10 15Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Ser Lys Val Leu Asp 20 25 30Leu Lys Asn 35 131 35 PRT Artificial Sequence Core polypeptide 131Val Asn Lys Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys Ala Val Val 1 5 10 15Ser Leu Ser Asn Gly Val Ser Val Leu Thr Ser Lys Val Leu Asp Leu 20 25 30Lys Asn Tyr 35 132 35 PRT Artificial Sequence Core polypeptide 132Asn Lys Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys Ala Val Val Ser 1 5 10 15Leu Ser Asn Gly Val Ser Val Leu Thr Ser Lys Val Leu Asp Leu Lys 20 25 30Asn Tyr Ile 35 133 35 PRT Artificial Sequence Core polypeptide 133Lys Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys Ala Val Val Ser Leu 1 5 10 15Ser Asn Gly Val Ser Val Leu Thr Ser Lys Val Leu Asp Leu Lys Asn 20 25 30Tyr Ile Asp 35 134 35 PRT Artificial Sequence Core polypeptide 134Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys Ala Val Val Ser Leu Ser 1 5 10 15Asn Gly Val Ser Val Leu Thr Ser Lys Val Leu Asp Leu Lys Asn Tyr 20 25 30Ile Asp Lys 35 135 35 PRT Artificial Sequence Core polypeptide 135Lys Ser Ala Leu Leu Ser Thr Asn Lys Ala Val Val Ser Leu Ser Asn 1 5 10 15Gly Val Ser Val Leu Thr Ser Lys Val Leu Asp Leu Lys Asn Tyr Ile 20 25 30Asp Lys Gln 35 136 35 PRT Artificial Sequence Core polypeptide 136Ser Ala Leu Leu Ser Thr Asn Lys Ala Val Val Ser Leu Ser Asn Gly 1 5 10 15Val Ser Val Leu Thr Ser Lys Val Leu Asp Leu Lys Asn Tyr Ile Asp 20 25 30Lys Gln Leu 35 137 35 PRT Artificial Sequence Core polypeptide 137Ala Leu Leu Ser Thr Asn Lys Ala Val Val Ser Leu Ser Asn Gly Val 1 5 10 15Ser Val Leu Thr Ser Lys Val Leu Asp Leu Lys Asn Tyr Ile Asp Lys 20 25 30Gln Leu Leu 35 138 35 PRT Artificial Sequence Core polypeptide 138Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile Lys Glu Asn Lys 1 5 10 15Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys Gln Glu Leu Asp 20 25 30Lys Tyr Lys 35 139 35 PRT Artificial Sequence Core polypeptide 139Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile Lys Glu Asn Lys Cys 1 5 10 15Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys Gln Glu Leu Asp Lys 20 25 30Tyr Lys Asn 35 140 35 PRT Artificial Sequence Core polypeptide 140Ser Val Ile Thr Ile Glu Leu Ser Asn Ile Lys Glu Asn Lys Cys Asn 1 5 10 15Gly Thr Asp Ala Lys Val Lys Leu Ile Lys Gln Glu Leu Asp Lys Tyr 20 25 30Lys Asn Ala 35 141 35 PRT Artificial Sequence Core polypeptide 141Val Ile Thr Ile Glu Leu Ser Asn Ile Lys Glu Asn Lys Cys Asn Gly 1 5 10 15Thr Asp Ala Lys Val Lys Leu Ile Lys Gln Glu Leu Asp Lys Tyr Lys 20 25 30Asn Ala Val 35 142 35 PRT Artificial Sequence Core polypeptide 142Ile Thr Ile Glu Leu Ser Asn Ile Lys Glu Asn Lys Cys Asn Gly Thr 1 5 10 15Asp Ala Lys Val Lys Leu Ile Lys Gln Glu Leu Asp Lys Tyr Lys Asn 20 25 30Ala Val Thr 35 143 35 PRT Artificial Sequence Core polypeptide 143Thr Ile Glu Leu Ser Asn Ile Lys Glu Asn Lys Cys Asn Gly Thr Asp 1 5 10 15Ala Lys Val Lys Leu Ile Lys Gln Glu Leu Asp Lys Tyr Lys Asn Ala 20 25 30Val Thr Glu 35 144 35 PRT Artificial Sequence Core polypeptide 144Ile Glu Leu Ser Asn Ile Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala 1 5 10 15Lys Val Lys Leu Ile Lys Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val 20 25 30Thr Glu Leu 35 145 35 PRT Artificial Sequence Core polypeptide 145Glu Leu Ser Asn Ile Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys 1 5 10 15Val Lys Leu Ile Lys Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr 20 25 30Glu Leu Gln 35 146 35 PRT Artificial Sequence Core polypeptide 146Leu Ser Asn Ile Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val 1 5 10 15Lys Leu Ile Lys Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu 20 25 30Leu Gln Leu 35 147 35 PRT Artificial Sequence Core polypeptide 147Ser Asn Ile Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys 1 5 10 15Leu Ile Lys Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu 20 25 30Gln Leu Leu 35 148 35 PRT Artificial Sequence Core polypeptide 148Asn Ile Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu 1 5 10 15Ile Lys Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln 20 25 30Leu Leu Met 35 149 35 PRT Artificial Sequence Core polypeptide 149Ile Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile 1 5 10 15Lys Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu 20 25 30Leu Met Gln 35 150 35 PRT Artificial Sequence Core polypeptide 150Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 1 5 10 15Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 20 25 30Met Gln Ser 35 151 35 PRT Artificial Sequence Core polypeptide 151Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys Gln 1 5 10 15Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu Met 20 25 30Gln Ser Thr 35 152 36 PRT Artificial Sequence Core polypeptide 152Leu Leu Asp Asn Phe Glu Ser Thr Trp Glu Gln Ser Lys Glu Leu Trp 1 5 10 15Glu Leu Gln Glu Ile Ser Ile Gln Asn Leu His Lys Ser Ala Leu Gln 20 25 30Glu Tyr Trp Asn 35 153 35 PRT Artificial Sequence Core polypeptide 153Ala Leu Gly Val Ala Thr Ser Ala Gln Ile Thr Ala Ala Val Ala Leu 1 5 10 15Val Glu Ala Lys Gln Ala Arg Ser Asp Ile Glu Lys Leu Lys Glu Ala 20 25 30Ile Arg Asp 35 154 35 PRT Artificial Sequence Core polypeptide 154Leu Gly Val Ala Thr Ser Ala Gln Ile Thr Ala Ala Val Ala Leu Val 1 5 10 15Glu Ala Lys Gln Ala Arg Ser Asp Ile Glu Lys Leu Lys Glu Ala Ile 20 25 30Arg Asp Thr 35 155 35 PRT Artificial Sequence Core polypeptide 155Gly Val Ala Thr Ser Ala Gln Ile Thr Ala Ala Val Ala Leu Val Glu 1 5 10 15Ala Lys Gln Ala Arg Ser Asp Ile Glu Lys Leu Lys Glu Ala Ile Arg 20 25 30Asp Thr Asn 35 156 35 PRT Artificial Sequence Core polypeptide 156Val Ala Thr Ser Ala Gln Ile Thr Ala Ala Val Ala Leu Val Glu Ala 1 5 10 15Lys Gln Ala Arg Ser Asp Ile Glu Lys Leu Lys Glu Ala Ile Arg Asp 20 25 30Thr Asn Lys 35 157 35 PRT Artificial Sequence Core polypeptide 157Ala Thr Ser Ala Gln Ile Thr Ala Ala Val Ala Leu Val Glu Ala Lys 1 5 10 15Gln Ala Arg Ser Asp Ile Glu Lys Leu Lys Glu Ala Ile Arg Asp Thr 20 25 30Asn Lys Ala 35 158 35 PRT Artificial Sequence Core polypeptide 158Thr Ser Ala Gln Ile Thr Ala Ala Val Ala Leu Val Glu Ala Lys Gln 1 5 10 15Ala Arg Ser Asp Ile Glu Lys Leu Lys Glu Ala Ile Arg Asp Thr Asn 20 25 30Lys Ala Val 35 159 35 PRT Artificial Sequence Core polypeptide 159Ser Ala Gln Ile Thr Ala Ala Val Ala Leu Val Glu Ala Lys Gln Ala 1 5 10 15Arg Ser Asp Ile Glu Lys Leu Lys Glu Ala Ile Arg Asp Thr Asn Lys 20 25 30Ala Val Gln 35 160 35 PRT Artificial Sequence Core polypeptide 160Ala Gln Ile Thr Ala Ala Val Ala Leu Val Glu Ala Lys Gln Ala Arg 1 5 10 15Ser Asp Ile Glu Lys Leu Lys Glu Ala Ile Arg Asp Thr Asn Lys Ala 20 25 30Val Gln Ser 35 161 35 PRT Artificial Sequence Core polypeptide 161Gln Ile Thr Ala Ala Val Ala Leu Val Glu Ala Lys Gln Ala Arg Ser 1 5 10 15Asp Ile Glu Lys Leu Lys Glu Ala Ile Arg Asp Thr Asn Lys Ala Val 20 25 30Gln Ser Val 35 162 35 PRT Artificial Sequence Core polypeptide 162Ile Thr Ala Ala Val Ala Leu Val Glu Ala Lys Gln Ala Arg Ser Asp 1 5 10 15Ile Glu Lys Leu Lys Glu Ala Ile Arg Asp Thr Asn Lys Ala Val Gln 20 25 30Ser Val Gln 35 163 35 PRT Artificial Sequence Core polypeptide 163Thr Ala Ala Val Ala Leu Val Glu Ala Lys Gln Ala Arg Ser Asp Ile 1 5 10 15Glu Lys Leu Lys Glu Ala Ile Arg Asp Thr Asn Lys Ala Val Gln Ser 20 25 30Val Gln Ser 35 164 35 PRT Artificial Sequence Core polypeptide 164Ala Ala Val Ala Leu Val Glu Ala Lys Gln Ala Arg Ser Asp Ile Glu 1 5 10 15Lys Leu Lys Glu Ala Ile Arg Asp Thr Asn Lys Ala Val Gln Ser Val 20 25 30Gln Ser Ser 35 165 35 PRT Artificial Sequence Core polypeptide 165Ala Val Ala Leu Val Glu Ala Lys Gln Ala Arg Ser Asp Ile Glu Lys 1 5 10 15Leu Lys Glu Ala Ile Arg Asp Thr Asn Lys Ala Val Gln Ser Val Gln 20 25 30Ser Ser Ile 35 166 35 PRT Artificial Sequence Core polypeptide 166Val Ala Leu Val Glu Ala Lys Gln Ala Arg Ser Asp Ile Glu Lys Leu 1 5 10 15Lys Glu Ala Ile Arg Asp Thr Asn Lys Ala Val Gln Ser Val Gln Ser 20 25 30Ser Ile Gly 35 167 35 PRT Artificial Sequence Core polypeptide 167Ala Leu Val Glu Ala Lys Gln Ala Arg Ser Asp Ile Glu Lys Leu Lys 1 5 10 15Glu Ala Ile Arg Asp Thr Asn Lys Ala Val Gln Ser Val Gln Ser Ser 20 25 30Ile Gly Asn 35 168 35 PRT Artificial Sequence Core polypeptide 168Leu Val Glu Ala Lys Gln Ala Arg Ser Asp Ile Glu Lys Leu Lys Glu 1 5 10 15Ala Ile Arg Asp Thr Asn Lys Ala Val Gln Ser Val Gln Ser Ser Ile 20 25 30Gly Asn Leu 35 169 35 PRT Artificial Sequence Core polypeptide 169Val Glu Ala Lys Gln Ala Arg Ser Asp Ile Glu Lys Leu Lys Glu Ala 1 5 10 15Ile Arg Asp Thr Asn Lys Ala Val Gln Ser Val Gln Ser Ser Ile Gly 20 25 30Asn Leu Ile 35 170 35 PRT Artificial Sequence Core polypeptide 170Glu Ala Lys Gln Ala Arg Ser Asp Ile Glu Lys Leu Lys Glu Ala Ile 1 5 10 15Arg Asp Thr Asn Lys Ala Val Gln Ser Val Gln Ser Ser Ile Gly Asn 20 25 30Leu Ile Val 35 171 35 PRT Artificial Sequence Core polypeptide 171Lys Gln Ala Arg Ser Asp Ile Glu Lys Leu Lys Glu Ala Ile Arg Asp 1 5 10 15Thr Asn Lys Ala Val Gln Ser Val Gln Ser Ser Ile Gly Asn Leu Ile 20 25 30Val Ala Ile 35 172 34 PRT Artificial Sequence Core polypeptide 172Gln Ala Arg Ser Asp Glu Lys Leu Lys Glu Ala Ile Arg Asp Thr Asn 1 5 10 15Lys Ala Val Gln Ser Val Gln Ser Ser Ile Gly Asn Leu Ile Val Ala 20 25 30Ile Lys 173 35 PRT Artificial Sequence Core polypeptide 173Gln Ala Arg Ser Asp Ile Glu Lys Leu Lys Glu Ala Ile Arg Asp Thr 1 5 10 15Asn Lys Ala Val Gln Ser Val Gln Ser Ser Ile Gly Asn Leu Ile Val 20 25 30Ala Ile Lys 35 174 35 PRT Artificial Sequence Core polypeptide 174Ala Arg Ser Asp Ile Glu Lys Leu Lys Glu Ala Ile Arg Asp Thr Asn 1 5 10 15Lys Ala Val Gln Ser Val Gln Ser Ser Ile Gly Asn Leu Ile Val Ala 20 25 30Ile Lys Ser 35 175 35 PRT Artificial Sequence Core polypeptide 175Arg Ser Asp Ile Glu Lys Leu Lys Glu Ala Ile Arg Asp Thr Asn Lys 1 5 10 15Ala Val Gln Ser Val Gln Ser Ser Ile Gly Asn Leu Ile Val Ala Ile 20 25 30Lys Ser Val 35 176 35 PRT Artificial Sequence Core polypeptide 176Ser Asp Ile Glu Lys Leu Lys Glu Ala Ile Arg Asp Thr Asn Lys Ala 1 5 10 15Val Gln Ser Val Gln Ser Ser Ile Gly Asn Leu Ile Val Ala Ile Lys 20 25 30Ser Val Gln 35 177 35 PRT Artificial Sequence Core polypeptide 177Asp Ile Glu Lys Leu Lys Glu Ala Ile Arg Asp Thr Asn Lys Ala Val 1 5 10 15Gln Ser Val Gln Ser Ser Ile Gly Asn Leu Ile Val Ala Ile Lys Ser 20 25 30Val Gln Asp 35 178 35 PRT Artificial Sequence Core polypeptide 178Ile Glu Lys Leu Lys Glu Ala Ile Arg Asp Thr Asn Lys Ala Val Gln 1 5 10 15Ser Val Gln Ser Ser Ile Gly Asn Leu Ile Val Ala Ile Lys Ser Val 20 25 30Gln Asp Tyr 35 179 35 PRT Artificial Sequence Core polypeptide 179Glu Lys Leu Lys Glu Ala Ile Arg Asp Thr Asn Lys Ala Val Gln Ser 1 5 10 15Val Gln Ser Ser Ile Gly Asn Leu Ile Val Ala Ile Lys Ser Val Gln 20 25 30Asp Tyr Val 35 180 35 PRT Artificial Sequence Core polypeptide 180Lys Leu Lys Glu Ala Ile Arg Asp Thr Asn Lys Ala Val Gln Ser Val 1 5 10 15Gln Ser Ser Ile Gly Asn Leu Ile Val Ala Ile Lys Ser Val Gln Asp 20 25 30Tyr Val Asn 35 181 35 PRT Artificial Sequence Core polypeptide 181Leu Lys Glu Ala Ile Arg Asp Thr Asn Lys Ala Val Gln Ser Val Gln 1 5 10 15Ser Ser Ile Gly Asn Leu Ile Val Ala Ile Lys Ser Val Gln Asp Tyr 20 25 30Val Asn Lys 35 182 35 PRT Artificial Sequence Core polypeptide 182Lys Glu Ala Ile Arg Asp Thr Asn Lys Ala Val Gln Ser Val Gln Ser 1 5 10 15Ser Ile Gly Asn Leu Ile Val Ala Ile Lys Ser Val Gln Asp Tyr Val 20 25 30Asn Lys Glu 35 183 35 PRT Artificial Sequence Core polypeptide 183Glu Ala Ile Arg Asp Thr Asn Lys Ala Val Gln Ser Val Gln Ser Ser 1 5 10 15Ile Gly Asn Leu Ile Val Ala Ile Lys Ser Val Gln Asp Tyr Val Asn 20 25 30Lys Glu Ile 35 184 35 PRT Artificial Sequence Core polypeptide 184Ala Ile Arg Asp Thr Asn Lys Ala Val Gln Ser Val Gln Ser Ser Ile 1 5 10 15Gly Asn Leu Ile Val Ala Ile Lys Ser Val Gln Asp Tyr Val Asn Lys 20 25 30Glu Ile Val 35 185 34 PRT Artificial Sequence Core polypeptide 185Ile Arg Asp Thr Asn Lys Ala Val Gln Ser Val Gln Ser Ser Ile Gly 1 5 10 15Asn Leu Ile Val Ala Ile Lys Ser Val Gln Asp Tyr Val Asn Lys Glu 20 25 30Ile Val 186 35 PRT Artificial Sequence Core polypeptide 186Tyr Thr Pro Asn Asp Ile Thr Leu Asn Asn Ser Val Ala Leu Asp Pro 1 5 10 15Ile Asp Ile Ser Ile Glu Leu Asn Lys Ala Lys Ser Asp Leu Glu Glu 20 25 30Ser Lys Glu 35 187 35 PRT Artificial Sequence Core polypeptide 187Thr Pro Asn Asp Ile Thr Leu Asn Asn Ser Val Ala Leu Asp Pro Ile 1 5 10 15Asp Ile Ser Ile Glu Leu Asn Lys Ala Lys Ser Asp Leu Glu Glu Ser 20 25 30Lys Glu Trp 35 188 35 PRT Artificial Sequence Core polypeptide 188Pro Asn Asp Ile Thr Leu Asn Asn Ser Val Ala Leu Asp Pro Ile Asp 1 5 10 15Ile Ser Ile Glu Leu Asn Lys Ala Lys Ser Asp Leu Glu Glu Ser Lys 20 25 30Glu Trp Ile 35 189 35 PRT Artificial Sequence Core polypeptide 189Asn Asp Ile Thr Leu Asn Asn Ser Val Ala Leu Asp Pro Ile Asp Ile 1 5 10 15Ser Ile Glu Leu Asn Lys Ala Lys Ser Asp Leu Glu Glu Ser Lys Glu 20 25 30Trp Ile Arg 35 190 35 PRT Artificial Sequence Core polypeptide 190Asp Ile Thr Leu Asn Asn Ser Val Ala Leu Asp Pro Ile Asp Ile Ser 1 5 10 15Ile Glu Leu Asn Lys Ala Lys Ser Asp Leu Glu Glu Ser Lys Glu Trp 20 25 30Ile Arg Arg 35 191 35 PRT Artificial Sequence Core polypeptide 191Ile Thr Leu Asn Asn Ser Val Ala Leu Asp Pro Ile Asp Ile Ser Ile 1 5 10 15Glu Leu Asn Lys Ala Lys Ser Asp Leu Glu Glu Ser Lys Glu Trp Ile 20 25 30Arg Arg Ser 35 192 35 PRT Artificial Sequence Core polypeptide 192Thr Leu Asn Asn Ser Val Ala Leu Asp Pro Ile Asp Ile Ser Ile Glu 1 5 10 15Leu Asn Lys Ala Lys Ser Asp Leu Glu Glu Ser Lys Glu Trp Ile Arg 20 25 30Arg Ser Asn 35 193 35 PRT Artificial Sequence Core polypeptide 193Leu Asn Asn Ser Val Ala Leu Asp Pro Ile Asp Ile Ser Ile Glu Leu 1 5 10 15Asn Lys Ala Lys Ser Asp Leu Glu Glu Ser Lys Glu Trp Ile Arg Arg 20 25 30Ser Asn Gln 35 194 35 PRT Artificial Sequence Core polypeptide 194Asn Asn Ser Val Ala Leu Asp Pro Ile Asp Ile Ser Ile Glu Leu Asn 1 5 10 15Lys Ala Lys Ser Asp Leu Glu Glu Ser Lys Glu Trp Ile Arg Arg Ser 20 25 30Asn Gln Lys 35 195 35 PRT Artificial Sequence Core polypeptide 195Asn Ser Val Ala Leu Asp Pro Ile Asp Ile Ser Ile Glu Leu Asn Lys 1 5 10 15Ala Lys Ser Asp Leu Glu Glu Ser Lys Glu Trp Ile Arg Arg Ser Asn 20 25 30Gln Lys Leu 35 196 35 PRT Artificial Sequence Core polypeptide 196Ser Val Ala Leu Asp Pro Ile Asp Ile Ser Ile Glu Leu Asn Lys Ala 1 5 10 15Lys Ser Asp Leu Glu Glu Ser Lys Glu Trp Ile Arg Arg Ser Asn Gln 20 25 30Lys Leu Asp 35 197 35 PRT Artificial Sequence Core polypeptide 197Val Ala Leu Asp Pro Ile Asp Ile Ser Ile Glu Leu Asn Lys Ala Lys 1 5 10 15Ser Asp Leu Glu Glu Ser Lys Glu Trp Ile Arg Arg Ser Asn Gln Lys 20 25 30Leu Asp Ser 35 198 35 PRT Artificial Sequence Core polypeptide 198Ala Leu Asp Pro Ile Asp Ile Ser Ile Glu Leu Asn Lys Ala Lys Ser 1 5 10 15Asp Leu Glu Glu Ser Lys Glu Trp Ile Arg Arg Ser Asn Gln Lys Leu 20 25 30Asp Ser Ile 35 199 35 PRT Artificial Sequence Core polypeptide 199Leu Asp Pro Ile Asp Ile Ser Ile Glu Leu Asn Lys Ala Lys Ser Asp 1 5 10 15Leu Glu Glu Ser Lys Glu Trp Ile Arg Arg Ser Asn Gln Lys Leu Asp 20 25 30Ser Ile Gly 35 200 35 PRT Artificial Sequence Core polypeptide 200Asp Pro Ile Asp Ile Ser Ile Glu Leu Asn Lys Ala Lys Ser Asp Leu 1 5 10 15Glu Glu Ser Lys Glu Trp Ile Arg Arg Ser Asn Gln Lys Leu Asp Ser 20 25 30Ile Gly Asn 35 201 35 PRT Artificial Sequence Core polypeptide 201Pro Ile Asp Ile Ser Ile Glu Leu Asn Lys Ala Lys Ser Asp Leu Glu 1 5 10 15Glu Ser Lys Glu Trp Ile Arg Arg Ser Asn Gln Lys Leu Asp Ser Ile 20 25 30Gly Asn Trp 35 202 35 PRT Artificial Sequence Core polypeptide 202Ile Asp Ile Ser Ile Glu Leu Asn Lys Ala Lys Ser Asp Leu Glu Glu 1 5 10 15Ser Lys Glu Trp Ile Arg Arg Ser Asn Gln Lys Leu Asp Ser Ile Gly 20 25 30Asn Trp His 35 203 35 PRT Artificial Sequence Core polypeptide 203Asp Ile Ser Ile Glu Leu Asn Lys Ala Lys Ser Asp Leu Glu Glu Ser 1 5 10 15Lys Glu Trp Ile Arg Arg Ser Asn Gln Lys Leu Asp Ser Ile Gly Asn 20 25 30Trp His Gln 35 204 35 PRT Artificial Sequence Core polypeptide 204Ile Ser Ile Glu Leu Asn Lys Ala Lys Ser Asp Leu Glu Glu Ser Lys 1 5 10 15Glu Trp Ile Arg Arg Ser Asn Gln Lys Leu Asp Ser Ile Gly Asn Trp 20 25 30His Gln Ser 35 205 35 PRT Artificial Sequence Core polypeptide 205Ser Ile Glu Leu Asn Lys Ala Lys Ser Asp Leu Glu Glu Ser Lys Glu 1 5 10 15Trp Ile Arg Arg Ser Asn Gln Lys Leu Asp Ser Ile Gly Asn Trp His 20 25 30Gln Ser Ser 35 206 35 PRT Artificial Sequence Core polypeptide 206Ile Glu Leu Asn Lys Ala Lys Ser Asp Leu Glu Glu Ser Lys Glu Trp 1 5 10 15Ile Arg Arg Ser Asn Gln Lys Leu Asp Ser Ile Gly Asn Trp His Gln 20 25 30Ser Ser Thr 35 207 35 PRT Artificial Sequence Core polypeptide 207Glu Leu Asn Lys Ala Lys Ser Asp Leu Glu Glu Ser Lys Glu Trp Ile 1 5 10 15Arg Arg Ser Asn Gln Lys Leu Asp Ser Ile Gly Asn Trp His Gln Ser 20 25 30Ser Thr Thr 35 208 36 PRT Artificial Sequence Core polypeptide 208Glu Leu Arg Ala Leu Arg Gly Glu Leu Arg Ala Leu Arg Gly Glu Leu 1 5 10 15Arg Ala Leu Arg Gly Glu Leu Arg Ala Leu Arg Gly Glu Leu Arg Ala 20 25 30Leu Arg Gly Lys 35 209 36 PRT Artificial Sequence Core polypeptide 209Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Gln Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Asn Trp Phe 35 210 36 PRT Artificial Sequence Core polypeptide 210Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asn Lys Trp Ala Ser Leu 20 25 30Trp Asn Trp Phe 35 211 36 PRT Artificial Sequence Core polypeptide 211Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Gln Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Asn Trp Phe 35 212 36 PRT Artificial Sequence Core polypeptide 212Tyr Thr Ser Leu Ile His Ser Leu Ile Gln Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Asn Trp Phe 35 213 36 PRT Artificial Sequence Core polypeptide 213Tyr Thr Ser Leu Ile His Ser Leu Ile Gln Gln Ser Gln Asn Gln Gln 1 5 10 15Gln Lys Asn Gln Gln Gln Leu Leu Gln Leu Asn Lys Trp Ala Ser Leu 20 25 30Trp Asn Trp Phe 35 214 17 PRT Artificial Sequence Core polypeptide 214Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp 1 5 10 15Phe 215 16 PRT Artificial Sequence Core polypeptide 215Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe 1 5 10 15 216 15 PRT Artificial Sequence Core polypeptide 216Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe 1 5 10 15 217 14 PRT Artificial Sequence Core polypeptide 217Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe 1 5 10 218 13 PRT Artificial Sequence Core polypeptide 218Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe 1 5 10 219 12 PRT Artificial Sequence Core polypeptide 219Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe 1 5 10 220 11 PRT Artificial Sequence Core polypeptide 220Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe 1 5 10 221 10 PRT Artificial Sequence Core polypeptide 221Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe 1 5 10 222 9 PRT Artificial Sequence Core polypeptide 222Lys Trp Ala Ser Leu Trp Asn Trp Phe 1 5 223 8 PRT Artificial Sequence Core polypeptide 223Trp Ala Ser Leu Trp Asn Trp Phe 1 5 224 7 PRT Artificial Sequence Core polypeptide 224Ala Ser Leu Trp Asn Trp Phe 1 5 225 18 PRT Artificial Sequence Core polypeptide 225Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys 226 36 PRT Artificial Sequence Core polypeptide 226Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Ala Asn Ala Ala 35 227 36 PRT Artificial Sequence Core polypeptide 227Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Gln Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Asn Trp Phe 35 228 36 PRT Artificial Sequence Core polypeptide 228Tyr Thr Ser Leu Ile Gln Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Gln Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Asn Trp Phe 35 229 14 PRT Artificial Sequence Core polypeptide 229Cys Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe 1 5 10 230 13 PRT Artificial Sequence Core polypeptide 230Leu Glu Leu Asp Lys Phe Ala Ser Leu Phe Asn Phe Phe 1 5 10 231 28 PRT Artificial Sequence Core polypeptide 231Glu Ala Ala Ala Arg Glu Ala Ala Ala Arg Glu Ala Ala Ala Arg Leu 1 5 10 15Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe 20 25 232 28 PRT Artificial Sequence Core polypeptide 232Arg Met Lys Gln Leu Glu Asp Lys Val Glu Glu Leu Leu Ser Lys Leu 1 5 10 15Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe 20 25 233 35 PRT Artificial Sequence Core polypeptide 233Pro Ser Leu Arg Asp Pro Ile Ser Ala Glu Ile Ser Ile Gln Ala Leu 1 5 10 15Ser Tyr Ala Leu Gly Gly Asp Ile Asn Lys Val Leu Glu Lys Leu Gly 20 25 30Tyr Ser Gly 35 234 35 PRT Artificial Sequence Core polypeptide 234Ser Leu Arg Asp Pro Ile Ser Ala Glu Ile Ser Ile Gln Ala Leu Ser 1 5 10 15Tyr Ala Leu Gly Gly Asp Ile Asn Lys Val Leu Glu Lys Leu Gly Tyr 20 25 30Ser Gly Gly 35 235 35 PRT Artificial Sequence Core polypeptide 235Leu Arg Asp Pro Ile Ser Ala Glu Ile Ser Ile Gln Ala Leu Ser Tyr 1 5 10 15Ala Leu Gly Gly Asp Ile Asn Lys Val Leu Glu Lys Leu Gly Tyr Ser 20 25 30Gly Gly Asp 35 236 35 PRT Artificial Sequence Core polypeptide 236Arg Asp Pro Ile Ser Ala Glu Ile Ser Ile Gln Ala Leu Ser Tyr Ala 1 5 10 15Leu Gly Gly Asp Ile Asn Lys Val Leu Glu Lys Leu Gly Tyr Ser Gly 20 25 30Gly Asp Leu 35 237 35 PRT Artificial Sequence Core polypeptide 237Asp Pro Ile Ser Ala Glu Ile Ser Ile Gln Ala Leu Ser Tyr Ala Leu 1 5 10 15Gly Gly Asp Ile Asn Lys Val Leu Glu Lys Leu Gly Tyr Ser Gly Gly 20 25 30Asp Leu Leu 35 238 35 PRT Artificial Sequence Core polypeptide 238Pro Ile Ser Ala Glu Ile Ser Ile Gln Ala Leu Ser Tyr Ala Leu Gly 1 5 10 15Gly Asp Ile Asn Lys Val Leu Glu Lys Leu Gly Tyr Ser Gly Gly Asp 20 25 30Leu Leu Gly 35 239 35 PRT Artificial Sequence Core polypeptide 239Ile Ser Ala Glu Ile Ser Ile Gln Ala Leu Ser Tyr Ala Leu Gly Gly 1 5 10 15Asp Ile Asn Lys Val Leu Glu Lys Leu Gly Tyr Ser Gly Gly Asp Leu 20 25 30Leu Gly Ile 35 240 35 PRT Artificial Sequence Core polypeptide 240Ser Ala Glu Ile Ser Ile Gln Ala Leu Ser Tyr Ala Leu Gly Gly Asp 1 5 10 15Ile Asn Lys Val Leu Glu Lys Leu Gly Tyr Ser Gly Gly Asp Leu Leu 20 25 30Gly Ile Leu 35 241 35 PRT Artificial Sequence Core polypeptide 241Ala Glu Ile Ser Ile Gln Ala Leu Ser Tyr Ala Leu Gly Gly Asp Ile 1 5 10 15Asn Lys Val Leu Glu Lys Leu Gly Tyr Ser Gly Gly Asp Leu Leu Gly 20 25 30Ile Leu Glu 35 242 35 PRT Artificial Sequence Core polypeptide 242Glu Ile Ser Ile Gln Ala Leu Ser Tyr Ala Leu Gly Gly Asp Ile Asn 1 5 10 15Lys Val Leu Glu Lys Leu Gly Tyr Ser Gly Gly Asp Leu Leu Gly Ile 20 25 30Leu Glu Ser 35 243 35 PRT Artificial Sequence Core polypeptide 243Ile Ser Ile Gln Ala Leu Ser Tyr Ala Leu Gly Gly Asp Ile Asn Lys 1 5 10 15Val Leu Glu Lys Leu Gly Tyr Ser Gly Gly Asp Leu Leu Gly Ile Leu 20 25 30Glu Ser Arg 35 244 35 PRT Artificial Sequence Core polypeptide 244Ser Ile Gln Ala Leu Ser Tyr Ala Leu Gly Gly Asp Ile Asn Lys Val 1 5 10 15Leu Glu Lys Leu Gly Tyr Ser Gly Gly Asp Leu Leu Gly Ile Leu Glu 20 25 30Ser Arg Gly 35 245 35 PRT Artificial Sequence Core polypeptide 245Ile Gln Ala Leu Ser Tyr Ala Leu Gly Gly Asp Ile Asn Lys Val Leu 1 5 10 15Glu Lys Leu Gly Tyr Ser Gly Gly Asp Leu Leu Gly Ile Leu Glu Ser 20 25 30Arg Gly Ile 35 246 35 PRT Artificial Sequence Core polypeptide 246Gln Ala Leu Ser Tyr Ala Leu Gly Gly Asp Ile Asn Lys Val Leu Glu 1 5 10 15Lys Leu Gly Tyr Ser Gly Gly Asp Leu Leu Gly Ile Leu Glu Ser Arg 20 25 30Gly Ile Lys 35 247 35 PRT Artificial Sequence Core polypeptide 247Ala Leu Ser Tyr Ala Leu Gly Gly Asp Ile Asn Lys Val Leu Glu Lys 1 5 10 15Leu Gly Tyr Ser Gly Gly Asp Leu Leu Gly Ile Leu Glu Ser Arg Gly 20 25 30Ile Lys Ala 35 248 35 PRT Artificial Sequence Core polypeptide 248Leu Ser Tyr Ala Leu Gly Gly Asp Ile Asn Lys Val Leu Glu Lys Leu 1 5 10 15Gly Tyr Ser Gly Gly Asp Leu Leu Gly Ile Leu Glu Ser Arg Gly Ile 20 25 30Lys Ala Arg 35 249 35 PRT Artificial Sequence Core polypeptide 249Pro Asp Ala Val Tyr Leu His Arg Ile Asp Leu Gly Pro Pro Ile Ser 1 5 10 15Leu Glu Arg Leu Asp Val Gly Thr Asn Leu Gly Asn Ala Ile Ala Lys 20 25 30Leu Glu Asp 35 250 35 PRT Artificial Sequence Core polypeptide 250Asp Ala Val Tyr Leu His Arg Ile Asp Leu Gly Pro Pro Ile Ser Leu 1 5 10 15Glu Arg Leu Asp Val Gly Thr Asn Leu Gly Asn Ala Ile Ala Lys Leu 20 25 30Glu Asp Ala 35 251 35 PRT Artificial Sequence Core polypeptide 251Ala Val Tyr Leu His Arg Ile Asp Leu Gly Pro Pro Ile Ser Leu Glu 1 5 10 15Arg Leu Asp Val Gly Thr Asn Leu Gly Asn Ala Ile Ala Lys Leu Glu 20 25 30Asp Ala Lys 35 252 35 PRT Artificial Sequence Core polypeptide 252Val Tyr Leu His Arg Ile Asp Leu Gly Pro Pro Ile Ser Leu Glu Arg 1 5 10 15Leu Asp Val Gly Thr Asn Leu Gly Asn Ala Ile Ala Lys Leu Glu Asp 20 25 30Ala Lys Glu 35 253 35 PRT Artificial Sequence Core polypeptide 253Tyr Leu His Arg Ile Asp Leu Gly Pro Pro Ile Ser Leu Glu Arg Leu 1 5 10 15Asp Val Gly Thr Asn Leu Gly Asn Ala Ile Ala Lys Leu Glu Asp Ala 20 25 30Lys Glu Leu 35 254 35 PRT Artificial Sequence Core polypeptide 254Leu His Arg Ile Asp Leu Gly Pro Pro Ile Ser Leu Glu Arg Leu Asp 1 5 10 15Val Gly Thr Asn Leu Gly Asn Ala Ile Ala Lys Leu Glu Asp Ala Lys 20 25 30Glu Leu Leu 35 255 35 PRT Artificial Sequence Core polypeptide 255His Arg Ile Asp Leu Gly Pro Pro Ile Ser Leu Glu Arg Leu Asp Val 1 5 10 15Gly Thr Asn Leu Gly Asn Ala Ile Ala Lys Leu Glu Asp Ala Lys Glu 20 25 30Leu Leu Glu 35 256 35 PRT Artificial Sequence Core polypeptide 256Arg Ile Asp Leu Gly Pro Pro Ile Ser Leu Glu Arg Leu Asp Val Gly 1 5 10 15Thr Asn Leu Gly Asn Ala Ile Ala Lys Leu Glu Asp Ala Lys Glu Leu 20 25 30Leu Glu Ser 35 257 35 PRT Artificial Sequence Core polypeptide 257Ile Asp Leu Gly Pro Pro Ile Ser Leu Glu Arg Leu Asp Val Gly Thr 1 5 10 15Asn Leu Gly Asn Ala Ile Ala Lys Leu Glu Asp Ala Lys Glu Leu Leu 20 25 30Glu Ser Ser 35 258 35 PRT Artificial Sequence Core polypeptide 258Asp Leu Gly Pro Pro Ile Ser Leu Glu Arg Leu Asp Val Gly Thr Asn 1 5 10 15Leu Gly Asn Ala Ile Ala Lys Leu Glu Asp Ala Lys Glu Leu Leu Glu 20 25 30Ser Ser Asp 35 259 35 PRT Artificial Sequence Core polypeptide 259Leu Gly Pro Pro Ile Ser Leu Glu Arg Leu Asp Val Gly Thr Asn Leu 1 5 10 15Gly Asn Ala Ile Ala Lys Leu Glu Asp Ala Lys Glu Leu Leu Glu Ser 20 25 30Ser Asp Gln 35 260 35 PRT Artificial Sequence Core polypeptide 260Gly Pro Pro Ile Ser Leu Glu Arg Leu Asp Val Gly Thr Asn Leu Gly 1 5 10 15Asn Ala Ile Ala Lys Leu Glu Asp Ala Lys Glu Leu Leu Glu Ser Ser 20 25 30Asp Gln Ile 35 261 35 PRT Artificial Sequence Core polypeptide 261Pro Pro Ile Ser Leu Glu Arg Leu Asp Val Gly Thr Asn Leu Gly Asn 1 5 10 15Ala Ile Ala Lys Leu Glu Asp Ala Lys Glu Leu Leu Glu Ser Ser Asp 20 25 30Gln Ile Leu 35 262 35 PRT Artificial Sequence Core polypeptide 262Pro Ile Ser Leu Glu Arg Leu Asp Val Gly Thr Asn Leu Gly Asn Ala 1 5 10 15Ile Ala Lys Leu Glu Asp Ala Lys Glu Leu Leu Glu Ser Ser Asp Gln 20 25 30Ile Leu Arg 35 263 34 PRT Artificial Sequence Core polypeptide 263Ile Ser Leu Glu Arg Leu Asp Val Gly Thr Asn Leu Gly Asn Ala Ile 1 5 10 15Ala Lys Leu Glu Asp Ala Lys Glu Leu Leu Glu Ser Ser Asp Gln Ile 20 25 30Arg Ser 264 35 PRT Artificial Sequence Core polypeptide 264Ser Leu Glu Arg Leu Asp Val Gly Thr Asn Leu Gly Asn Ala Ile Ala 1 5 10 15Lys Leu Glu Asp Ala Lys Glu Leu Leu Glu Ser Ser Asp Gln Ile Leu 20 25 30Arg Ser Met 35 265 35 PRT Artificial Sequence Core polypeptide 265Leu Glu Arg Leu Asp Val Gly Thr Asn Leu Gly Asn Ala Ile Ala Lys 1 5 10 15Leu Glu Asp Ala Lys Glu Leu Leu Glu Ser Ser Asp Gln Ile Leu Arg 20 25 30Ser Met Lys 35 266 13 PRT Artificial Sequence Core polypeptide 266Glu Trp Ile Arg Arg Ser Asn Gln Lys Leu Asp Ser Ile 1 5 10 267 13 PRT Artificial Sequence Core polypeptide 267Leu Glu Leu Asp Lys Trp Ala Ser Leu Ala Asn Ala Phe 1 5 10 268 13 PRT Artificial Sequence Core polypeptide 268Leu Glu Leu Asp Lys Trp Ala Ser Leu Phe Asn Phe Phe 1 5 10 269 13 PRT Artificial Sequence Core polypeptide 269Leu Glu Leu Asp Lys Trp Ala Ser Leu Ala Asn Trp Phe 1 5 10 270 13 PRT Artificial Sequence Core polypeptide 270Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Ala Phe 1 5 10 271 35 PRT Artificial Sequence Core polypeptide 271Glu Leu Gly Asn Val Asn Asn Ser Ile Ser Asn Ala Leu Asp Lys Leu 1 5 10 15Glu Glu Ser Asn Ser Lys Leu Asp Lys Val Asn Val Lys Leu Thr Ser 20 25 30Thr Ser Ala 35 272 35 PRT Artificial Sequence Core polypeptide 272Thr Glu Leu Gly Asn Val Asn Asn Ser Ile Ser Asn Ala Leu Asp Lys 1 5 10 15Leu Glu Glu Ser Asn Ser Lys Leu Asp Lys Val Asn Val Lys Leu Thr 20 25 30Ser Thr Ser 35 273 35 PRT Artificial Sequence Core polypeptide 273Ser Thr Glu Leu Gly Asn Val Asn Asn Ser Ile Ser Asn Ala Leu Asp 1 5 10 15Lys Leu Glu Glu Ser Asn Ser Lys Leu Asp Lys Val Asn Val Lys Leu 20 25 30Thr Ser Thr 35 274 35 PRT Artificial Sequence Core polypeptide 274Ile Ser Thr Glu Leu Gly Asn Val Asn Asn Ser Ile Ser Asn Ala Leu 1 5 10 15Asp Lys Leu Glu Glu Ser Asn Ser Lys Leu Asp Lys Val Asn Val Lys 20 25 30Leu Thr Ser 35 275 35 PRT Artificial Sequence Core polypeptide 275Asp Ile Ser Thr Glu Leu Gly Asn Val Asn Asn Ser Ile Ser Asn Ala 1 5 10 15Leu Asp Lys Leu Glu Glu Ser Asn Ser Lys Leu Asp Lys Val Asn Val 20 25 30Lys Leu Thr 35 276 35 PRT Artificial Sequence Core polypeptide 276Leu Asp Ile Ser Thr Glu Leu Gly Asn Val Asn Asn Ser Ile Ser Asn 1 5 10 15Ala Leu Asp Lys Leu Glu Glu Ser Asn Ser Lys Leu Asp Lys Val Asn 20 25 30Val Lys Leu 35 277 35 PRT Artificial Sequence Core polypeptide 277Asn Leu Asp Ile Ser Thr Glu Leu Gly Asn Val Asn Asn Ser Ile Ser 1 5 10 15Asn Ala Leu Asp Lys Leu Glu Glu Ser Asn Ser Lys Leu Asp Lys Val 20 25 30Asn Val Lys 35 278 35 PRT Artificial Sequence Core polypeptide 278Gly Asn Leu Asp Ile Ser Thr Glu Leu Gly Asn Val Asn Asn Ser Ile 1 5 10 15Ser Asn Ala Leu Asp Lys Leu Glu Glu Ser Asn Ser Lys Leu Asp Lys 20 25 30Val Asn Val 35 279 35 PRT Artificial Sequence Core polypeptide 279Thr Gly Asn Leu Asp Ile Ser Thr Glu Leu Gly Asn Val Asn Asn Ser 1 5 10 15Ile Ser Asn Ala Leu Asp Lys Leu Glu Glu Ser Asn Ser Lys Leu Asp 20 25 30Lys Val Asn 35 280 35 PRT Artificial Sequence Core polypeptide 280Val Thr Gly Asn Leu Asp Ile Ser Thr Glu Leu Gly Asn Val Asn Asn 1 5 10 15Ser Ile Ser Asn Ala Leu Asp Lys Leu Glu Glu Ser Asn Ser Lys Leu 20 25 30Asp Lys Val 35 281 35 PRT Artificial Sequence Core polypeptide 281Ile Val Thr Gly Asn Leu Asp Ile Ser Thr Glu Leu Gly Asn Val Asn 1 5 10 15Asn Ser Ile Ser Asn Ala Leu Asp Lys Leu Glu Glu Ser Asn Ser Lys 20 25 30Leu Asp Lys 35 282 35 PRT Artificial Sequence Core polypeptide 282Val Ile Val Thr Gly Asn Leu Asp Ile Ser Thr Glu Leu Gly Asn Val 1 5 10 15Asn Asn Ser Ile Ser Asn Ala Leu Asp Lys Leu Glu Glu Ser Asn Ser 20 25 30Lys Leu Asp 35 283 35 PRT Artificial Sequence Core polypeptide 283Gln Val Ile Val Thr Gly Asn Leu Asp Ile Ser Thr Glu Leu Gly Asn 1 5 10 15Val Asn Asn Ser Ile Ser Asn Ala Leu Asp Lys Leu Glu Glu Ser Asn 20 25 30Ser Lys Leu 35 284 35 PRT Artificial Sequence Core polypeptide 284Ser Gln Val Ile Val Thr Gly Asn Leu Asp Ile Ser Thr Glu Leu Gly 1 5 10 15Asn Val Asn Asn Ser Ile Ser Asn Ala Leu Asp Lys Leu Glu Glu Ser 20 25 30Asn Ser Lys 35 285 35 PRT Artificial Sequence Core polypeptide 285Asp Ser Gln Val Ile Val Thr Gly Asn Leu Asp Ile Ser Thr Glu Leu 1 5 10 15Gly Asn Val Asn Asn Ser Ile Ser Asn Ala Leu Asp Lys Leu Glu Glu 20 25 30Ser Asn Ser 35 286 35 PRT Artificial Sequence Core polypeptide 286Leu Asp Ser Gln Val Ile Val Thr Gly Asn Leu Asp Ile Ser Thr Glu 1 5 10 15Leu Gly Asn Val Asn Asn Ser Ile Ser Asn Ala Leu Asp Lys Leu Glu 20 25 30Glu Ser Asn 35 287 35 PRT Artificial Sequence Core polypeptide 287Ile Leu Asp Ser Gln Val Ile Val Thr Gly Asn Leu Asp Ile Ser Thr 1 5 10 15Glu Leu Gly Asn Val Asn Asn Ser Ile Ser Asn Ala Leu Asp Lys Leu 20 25 30Glu Glu Ser 35 288 35 PRT Artificial Sequence Core polypeptide 288Ser Ile Leu Asp Ser Gln Val Ile Val Thr Gly Asn Leu Asp Ile Ser 1 5 10 15Thr Glu Leu Gly Asn Val Asn Asn Ser Ile Ser Asn Ala Leu Asp Lys 20 25 30Leu Glu Glu 35 289 35 PRT Artificial Sequence Core polypeptide 289Ile Ser Ile Leu Asp Ser Gln Val Ile Val Thr Gly Asn Leu Asp Ile 1 5 10 15Ser Thr Glu Leu Gly Asn Val Asn Asn Ser Ile Ser Asn Ala Leu Asp 20 25 30Lys Leu Glu 35 290 35 PRT Artificial Sequence Core polypeptide 290Asn Ile Ser Ile Leu Asp Ser Gln Val Ile Val Thr Gly Asn Leu Asp 1 5 10 15Ile Ser Thr Glu Leu Gly Asn Val Asn Asn Ser Ile Ser Asn Ala Leu 20 25 30Asp Lys Leu 35 291 35 PRT Artificial Sequence Core polypeptide 291Lys Asn Ile Ser Ile Leu Asp Ser Gln Val Ile Val Thr Gly Asn Leu 1 5 10 15Asp Ile Ser Thr Glu Leu Gly Asn Val Asn Asn Ser Ile Ser Asn Ala 20 25 30Leu Asp Lys 35 292 35 PRT Artificial Sequence Core polypeptide 292Gln Lys Asn Ile Ser Ile Leu Asp Ser Gln Val Ile Val Thr Gly Asn 1 5 10 15Leu Asp Ile Ser Thr Glu Leu Gly Asn Val Asn Asn Ser Ile Ser Asn 20 25 30Ala Leu Asp 35 293 35 PRT Artificial Sequence Core polypeptide 293Tyr Gln Lys Asn Ile Ser Ile Leu Asp Ser Gln Val Ile Val Thr Gly 1 5 10 15Asn Leu Asp Ile Ser Thr Glu Leu Gly Asn Val Asn Asn Ser Ile Ser 20 25 30Asn Ala Leu 35 294 35 PRT Artificial Sequence Core polypeptide 294Thr Tyr Gln Lys Asn Ile Ser Ile Leu Asp Ser Gln Val Ile Val Thr 1 5 10 15Gly Asn Leu Asp Ile Ser Thr Glu Leu Gly Asn Val Asn Asn Ser Ile 20 25 30Ser Asn Ala 35 295 35 PRT Artificial Sequence Core polypeptide 295Ala Thr Tyr Gln Lys Asn Ile Ser Ile Leu Asp Ser Gln Val Ile Val 1 5 10 15Thr Gly Asn Leu Asp Ile Ser Thr Glu Leu Gly Asn Val Asn Asn Ser 20 25 30Ile Ser Asn 35 296 35 PRT Artificial Sequence Core polypeptide 296Asp Ala Thr Tyr Gln Lys Asn Ile Ser Ile Leu Asp Ser Gln Val Ile 1 5 10 15Val Thr Gly Asn Leu Asp Ile Ser Thr Glu Leu Gly Asn Val Asn Asn 20 25 30Ser Ile Ser 35 297 35 PRT Artificial Sequence Core polypeptide 297Phe Asp Ala Thr Tyr Gln Lys Asn Ile Ser Ile Leu Asp Ser Gln Val 1 5 10 15Ile Val Thr Gly Asn Leu Asp Ile Ser Thr Glu Leu Gly Asn Val Asn 20 25 30Asn Ser Ile 35 298 35 PRT Artificial Sequence Core polypeptide 298Glu Phe Asp Ala Thr Tyr Gln Lys Asn Ile Ser Ile Leu Asp Ser Gln 1 5 10 15Val Ile Val Thr Gly Asn Leu Asp Ile Ser Thr Glu Leu Gly Asn Val 20 25 30Asn Asn Ser 35 299 35 PRT Artificial Sequence Core polypeptide 299Gly Glu Phe Asp Ala Thr Tyr Gln Lys Asn Ile Ser Ile Leu Asp Ser 1 5 10 15Gln Val Ile Val Thr Gly Asn Leu Asp Ile Ser Thr Glu Leu Gly Asn 20 25 30Val Asn Asn 35 300 35 PRT Artificial Sequence Core polypeptide 300Ser Gly Glu Phe Asp Ala Thr Tyr Gln Lys Asn Ile Ser Ile Leu Asp 1 5 10 15Ser Gln Val Ile Val Thr Gly Asn Leu Asp Ile Ser Thr Glu Leu Gly 20 25 30Asn Val Asn 35 301 35 PRT Artificial Sequence Core polypeptide 301Leu Ser Gly Glu Phe Asp Ala Thr Tyr Gln Lys Asn Ile Ser Ile Leu 1 5 10 15Asp Ser Gln Val Ile Val Thr Gly Asn Leu Asp Ile Ser Thr Glu Leu 20 25 30Gly Asn Val 35 302 35 PRT Artificial Sequence Core polypeptide 302Arg Leu Ser Gly Glu Phe Asp Ala Thr Tyr Gln Lys Asn Ile Ser Ile 1 5 10 15Leu Asp Ser Gln Val Ile Val Thr Gly Asn Leu Asp Ile Ser Thr Glu 20 25 30Leu Gly Asn 35 303 35 PRT Artificial Sequence Core polypeptide 303Leu Arg Leu Ser Gly Glu Phe Asp Ala Thr Tyr Gln Lys Asn Ile Ser 1 5 10 15Ile Leu Asp Ser Gln Val Ile Val Thr Gly Asn Leu Asp Ile Ser Thr 20 25 30Glu Leu Gly 35 304 35 PRT Artificial Sequence Core polypeptide 304Thr Leu Arg Leu Ser Gly Glu Phe Asp Ala Thr Tyr Gln Lys Asn Ile 1 5 10 15Ser Ile Leu Asp Ser Gln Val Ile Val Thr Gly Asn Leu Asp Ile Ser 20 25 30Thr Glu Leu 35 305 35 PRT Artificial Sequence Core polypeptide 305Ile Thr Leu Arg Leu Ser Gly Glu Phe Asp Ala Thr Tyr Gln Lys Asn 1 5 10 15Ile Ser Ile Leu Asp Ser Gln Val Ile Val Thr Gly Asn Leu Asp Ile 20 25 30Ser Thr Glu 35 306 35 PRT Artificial Sequence Core polypeptide 306Gly Ile Thr Leu Arg Leu Ser Gly Glu Phe Asp Ala Thr Tyr Gln Lys 1 5 10 15Asn Ile Ser Ile Leu Asp Ser Gln Val Ile Val Thr Gly Asn Leu Asp 20 25 30Ile Ser Thr 35 307 35 PRT Artificial Sequence Core polypeptide 307Thr Ala Thr Ile Glu Ala Val His Glu Val Thr Asp Gly Leu Ser Gln 1 5 10 15Leu Ala Val Ala Val Gly Lys Met Gln Gln Phe Val Asn Asp Gln Phe 20 25 30Asn Asn Thr 35 308 35 PRT Artificial Sequence Core polypeptide 308Ile Thr Ala Thr Ile Glu Ala Val His Glu Val Thr Asp Gly Leu Ser 1 5 10 15Gln Leu Ala Val Ala Val Gly Lys Met Gln Gln Phe Val Asn Asp Gln 20 25 30Phe Asn Asn 35 309 35 PRT Artificial Sequence Core polypeptide 309Ser Ile Thr Ala Thr Ile Glu Ala Val His Glu Val Thr Asp Gly Leu 1 5 10 15Ser Gln Leu Ala Val Ala Val Gly Lys Met Gln Gln Phe Val Asn Asp 20 25 30Gln Phe Asn 35 310 35 PRT Artificial Sequence Core polypeptide 310Lys Glu Ser Ile Thr Ala Thr Ile Glu Ala Val His Glu Val Thr Asp 1 5 10 15Gly Leu Ser Gln Leu Ala Val Ala Val Gly Lys Met Gln Gln Phe Val 20 25 30Asn Asp Gln 35 311 35 PRT Artificial Sequence Core polypeptide 311Leu Lys Glu Ser Ile Thr Ala Thr Ile Glu Ala Val His Glu Val Thr 1 5 10 15Asp Gly Leu Ser Gln Leu Ala Val Ala Val Gly Lys Met Gln Gln Phe 20 25 30Val Asn Asp 35 312 35 PRT Artificial Sequence Core polypeptide 312Arg Leu Lys Glu Ser Ile Thr Ala Thr Ile Glu Ala Val His Glu Val 1 5 10 15Thr Asp Gly Leu Ser Gln Leu Ala Val Ala Val Gly Lys Met Gln Gln 20 25 30Phe Val Asn 35 313 35 PRT Artificial Sequence Core polypeptide 313Leu Arg Leu Lys Glu Ser Ile Thr Ala Thr Ile Glu Ala Val His Glu 1 5 10 15Val Thr Asp Gly Leu Ser Gln Leu Ala Val Ala Val Gly Lys Met Gln 20 25 30Gln Phe Val 35 314 35 PRT Artificial Sequence Core polypeptide 314Ile Leu Arg Leu Lys Glu Ser Ile Thr Ala Thr Ile Glu Ala Val His 1 5 10 15Glu Val Thr Asp Gly Leu Ser Gln Leu Ala Val Ala Val Gly Lys Met 20 25 30Gln Gln Phe 35 315 35 PRT Artificial Sequence Core polypeptide 315Asn Ile Leu Arg Leu Lys Glu Ser Ile Thr Ala Thr Ile Glu Ala Val 1 5 10 15His Glu Val Thr Asp Gly Leu Ser Gln Leu Ala Val Ala Val Gly Lys 20 25 30Met Gln Gln 35 316 35 PRT Artificial Sequence Core polypeptide 316Ala Asn Ile Leu Arg Leu Lys Glu Ser Ile Thr Ala Thr Ile Glu Ala 1 5 10 15Val His Glu Val Thr Asp Gly Leu Ser Gln Leu Ala Val Ala Val Gly 20 25 30Lys Met Gln 35 317 35 PRT Artificial Sequence Core polypeptide 317Ala Ala Asn Ile Leu Arg Leu Lys Glu Ser Ile Thr Ala Thr Ile Glu 1 5 10 15Ala Val His Glu Val Thr Asp Gly Leu Ser Gln Leu Ala Val Ala Val 20 25 30Gly Lys Met 35 318 35 PRT Artificial Sequence Core polypeptide 318His Lys Cys Asp Asp Glu Cys Met Asn Ser Val Lys Asn Gly Thr Tyr 1 5 10 15Asp Tyr Pro Lys Tyr Glu Glu Glu Ser Lys Leu Asn Arg Asn Glu Ile 20 25 30Lys Gly Val 35 319 35 PRT Artificial Sequence Core polypeptide 319Lys Cys Asp Asp Glu Cys Met Asn Ser Val Lys Asn Gly Thr Tyr Asp 1 5 10 15Tyr Pro Lys Tyr Glu Glu Glu Ser Lys Leu Asn Arg Asn Glu Ile Lys 20 25 30Gly Val Lys 35 320 35 PRT Artificial Sequence Core polypeptide 320Cys Asp Asp Glu Cys Met Asn Ser Val Lys Asn Gly Thr Tyr Asp Tyr 1 5 10 15Pro Lys Tyr Glu Glu Glu Ser Lys Leu Asn Arg Asn Glu Ile Lys Gly 20 25 30Val Lys Leu 35 321 35 PRT Artificial Sequence Core polypeptide 321Asp Asp Glu Cys Met Asn Ser Val Lys Asn Gly Thr Tyr Asp Tyr Pro 1 5 10 15Lys Tyr Glu Glu Glu Ser Lys Leu Asn Arg Asn Glu Ile Lys Gly Val 20 25 30Lys Leu Ser 35 322 35 PRT Artificial Sequence Core polypeptide 322Asp Glu Cys Met Asn Ser Val Lys Asn Gly Thr Tyr Asp Tyr Pro Lys 1 5 10 15Tyr Glu Glu Glu Ser Lys Leu Asn Arg Asn Glu Ile Lys Gly Val Lys 20 25 30Leu Ser Ser 35 323 35 PRT Artificial Sequence Core polypeptide 323Glu Cys Met Asn Ser Val Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr 1 5 10 15Glu Glu Glu Ser Lys Leu Asn Arg Asn Glu Ile Lys Gly Val Lys Leu 20 25 30Ser Ser Met 35 324 35 PRT Artificial Sequence Core polypeptide 324Cys Met Asn Ser Val Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Glu 1 5 10 15Glu Glu Ser Lys Leu Asn Arg Asn Glu Ile Lys Gly Val Lys Leu Ser 20 25 30Ser Met Gly 35 325 35 PRT Artificial Sequence Core polypeptide 325Met Asn Ser Val Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Glu Glu 1 5 10 15Glu Ser Lys Leu Asn Arg Asn Glu Ile Lys Gly Val Lys Leu Ser Ser 20 25 30Met Gly Val 35 326 35 PRT Artificial Sequence Core polypeptide 326Asn Ser Val Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Glu Glu Glu 1 5 10 15Ser Lys Leu Asn Arg Asn Glu Ile Lys Gly Val Lys Leu Ser Ser Met 20 25 30Gly Val Tyr 35 327 35 PRT Artificial Sequence Core polypeptide 327Ser Val Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Glu Glu Glu Ser 1 5 10 15Lys Leu Asn Arg Asn Glu Ile Lys Gly Val Lys Leu Ser Ser Met Gly 20 25 30Val Tyr Gln 35 328 35 PRT Artificial Sequence Core polypeptide 328Val Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Glu Glu Glu Ser Lys 1 5 10 15Leu Asn Arg Asn Glu Ile Lys Gly Val Lys Leu Ser Ser Met Gly Val 20 25 30Tyr Gln Ile 35 329 35 PRT Artificial Sequence Core polypeptide 329Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Glu Glu Glu Ser Lys Leu 1 5 10 15Asn Arg Asn Glu Ile Lys Gly Val Lys Leu Ser Ser Met Gly Val Tyr 20 25 30Gln Ile Leu 35 330 13 PRT Artificial Sequence Core polypeptide 330Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu His Asn Val 1 5 10 331 35 PRT Artificial Sequence Core polypeptide 331Val Val Leu Ala Gly Ala Ala Leu Gly Val Ala Thr Ala Ala Gln Ile 1 5 10 15Thr Ala Gly Ile Ala Leu His Gln Ser Met Leu Asn Ser Gln Ala Ile 20 25 30Asp Asn Leu 35 332 35 PRT Artificial Sequence Core polypeptide 332Val Leu Ala Gly Ala Ala Leu Gly Val Ala Thr Ala Ala Gln Ile Thr 1 5 10 15Ala Gly Ile Ala Leu His Gln Ser Met Leu Asn Ser Gln Ala Ile Asp 20 25 30Asn Leu Arg 35 333 35 PRT Artificial Sequence Core polypeptide 333Leu Ala Gly Ala Ala Leu Gly Val Ala Thr Ala Ala Gln Ile Thr Ala 1 5 10 15Gly Ile Ala Leu His Gln Ser Met Leu Asn Ser Gln Ala Ile Asp Asn 20 25 30Leu Arg Ala 35 334 35 PRT Artificial Sequence Core polypeptide 334Ala Gly Ala Ala Leu Gly Val Ala Thr Ala Ala Gln Ile Thr Ala Gly 1 5 10 15Ile Ala Leu His Gln Ser Met Leu Asn Ser Gln Ala Ile Asp Asn Leu 20 25 30Arg Ala Ser 35 335 35 PRT Artificial Sequence Core polypeptide 335Gly Ala Ala Leu Gly Val Ala Thr Ala Ala Gln Ile Thr Ala Gly Ile 1 5 10 15Ala Leu His Gln Ser Met Leu Asn Ser Gln Ala Ile Asp Asn Leu Arg 20 25 30Ala Ser Leu 35 336 35 PRT Artificial Sequence Core polypeptide 336Ala Ala Leu Gly Val Ala Thr Ala Ala Gln Ile Thr Ala Gly Ile Ala 1 5 10 15Leu His Gln Ser Met Leu Asn Ser Gln Ala Ile Asp Asn Leu Arg Ala 20 25 30Ser Leu Glu 35 337 35 PRT Artificial Sequence Core polypeptide 337Ala Leu Gly Val Ala Thr Ala Ala Gln Ile Thr Ala Gly Ile Ala Leu 1 5 10 15His Gln Ser Met Leu Asn Ser Gln Ala Ile Asp Asn Leu Arg Ala Ser 20 25 30Leu Glu Thr 35 338 35 PRT Artificial Sequence Core polypeptide 338Leu Gly Val Ala Thr Ala Ala Gln Ile Thr Ala Gly Ile Ala Leu His 1 5 10 15Gln Ser Met Leu Asn Ser Gln Ala Ile Asp Asn Leu Arg Ala Ser Leu 20 25 30Glu Thr Thr 35 339 35 PRT Artificial Sequence Core polypeptide 339Gly Val Ala Thr Ala Ala Gln Ile Thr Ala Gly Ile Ala Leu His Gln 1 5 10 15Ser Met Leu Asn Ser Gln Ala Ile Asp Asn Leu Arg Ala Ser Leu Glu 20 25 30Thr Thr Asn 35 340 35 PRT Artificial Sequence Core polypeptide 340Val Ala Thr Ala Ala Gln Ile Thr Ala Gly Ile Ala Leu His Gln Ser 1 5 10 15Met Leu Asn Ser Gln Ala Ile Asp Asn Leu Arg Ala Ser Leu Glu Thr 20 25 30Thr Asn Gln 35 341 35 PRT Artificial Sequence Core polypeptide 341Ala Thr Ala Ala Gln Ile Thr Ala Gly Ile Ala Leu His Gln Ser Met 1 5 10 15Leu Asn Ser Gln Ala Ile Asp Asn Leu Arg Ala Ser Leu Glu Thr Thr 20 25 30Asn Gln Ala 35 342 35 PRT Artificial Sequence Core polypeptide 342Thr Ala Ala Gln Ile Thr Ala Gly Ile Ala Leu His Gln Ser Met Leu 1 5 10 15Asn Ser Gln Ala Ile Asp Asn Leu Arg Ala Ser Leu Glu Thr Thr Asn 20 25 30Gln Ala Ile 35 343 35 PRT Artificial Sequence Core polypeptide 343Ala Ala Gln Ile Thr Ala Gly Ile Ala Leu His Gln Ser Met Leu Asn 1 5 10 15Ser Gln Ala Ile Asp Asn Leu Arg Ala Ser Leu Glu Thr Thr Asn Gln 20 25 30Ala Ile Glu 35 344 35 PRT Artificial Sequence Core polypeptide 344Ala Gln Ile Thr Ala Gly Ile Ala Leu His Gln Ser Met Leu Asn Ser 1 5 10 15Gln Ala Ile Asp Asn Leu Arg Ala Ser Leu Glu Thr Thr Asn Gln Ala 20 25 30Ile Glu Ala 35 345 35 PRT Artificial Sequence Core polypeptide 345Gln Ile Thr Ala Gly Ile Ala Leu His Gln Ser Met Leu Asn Ser Gln 1 5 10 15Ala Ile Asp Asn Leu Arg Ala Ser Leu Glu Thr Thr Asn Gln Ala Ile 20 25 30Glu Ala Ile 35 346 35 PRT Artificial Sequence Core polypeptide 346Ile Thr Ala Gly Ile Ala Leu His Gln Ser Met Leu Asn Ser Gln Ala 1 5 10 15Ile Asp Asn Leu Arg Ala Ser Leu Glu Thr Thr Asn Gln Ala Ile Glu 20 25 30Ala Ile Arg 35 347 35 PRT Artificial Sequence Core polypeptide 347Thr Ala Gly Ile Ala Leu His Gln Ser Met Leu Asn Ser Gln Ala Ile 1 5 10 15Asp Asn Leu Arg Ala Ser Leu Glu Thr Thr Asn Gln Ala Ile Glu Ala 20 25 30Ile Arg Gln 35 348 35 PRT Artificial Sequence Core polypeptide 348Ala Gly Ile Ala Leu His Gln Ser Met Leu Asn Ser Gln Ala Ile Asp 1 5 10 15Asn Leu Arg Ala Ser Leu Glu Thr Thr Asn Gln Ala Ile Glu Ala Ile 20 25 30Arg Gln Ala 35 349 35 PRT Artificial Sequence Core polypeptide 349Gly Ile Ala Leu His Gln Ser Met Leu Asn Ser Gln Ala Ile Asp Asn 1 5 10 15Leu Arg Ala Ser Leu Glu Thr Thr Asn Gln Ala Ile Glu Ala Ile Arg 20 25 30Gln Ala Gly 35 350 35 PRT Artificial Sequence Core polypeptide 350Ile Ala Leu His Gln Ser Met Leu Asn Ser Gln Ala Ile Asp Asn Leu 1 5 10 15Arg Ala Ser Leu Glu Thr Thr Asn Gln Ala Ile Glu Ala Ile Arg Gln 20 25 30Ala Gly Gln 35 351 35 PRT Artificial Sequence Core polypeptide 351Ala Leu His Gln Ser Met Leu Asn Ser Gln Ala Ile Asp Asn Leu Arg 1 5 10 15Ala Ser Leu Glu Thr Thr Asn Gln Ala Ile Glu Ala Ile Arg Gln Ala 20 25 30Gly Gln Glu 35 352 35 PRT Artificial Sequence Core polypeptide 352Leu His Gln Ser Met Leu Asn Ser Gln Ala Ile Asp Asn Leu Arg Ala 1 5 10 15Ser Leu Glu Thr Thr Asn Gln Ala Ile Glu Ala Ile Arg Gln Ala Gly 20 25 30Gln Glu Met 35 353 35 PRT Artificial Sequence Core polypeptide 353His Gln Ser Met Leu Asn Ser Gln Ala Ile Asp Asn Leu Arg Ala Ser 1 5 10 15Leu Glu Thr Thr Asn Gln Ala Ile Glu Ala Ile Arg Gln Ala Gly Gln 20 25 30Glu Met Ile 35 354 35 PRT Artificial Sequence Core polypeptide 354Gln Ser Met Leu Asn Ser Gln Ala Ile Asp Asn Leu Arg Ala Ser Leu 1 5 10 15Glu Thr Thr Asn Gln Ala Ile Glu Ala Ile Arg Gln Ala Gly Gln Glu 20 25 30Met Ile Leu 35 355 35 PRT Artificial Sequence Core polypeptide 355Ser Met Leu Asn Ser Gln Ala Ile Asp Asn Leu Arg Ala Ser Leu Glu 1 5 10 15Thr Thr Asn Gln Ala Ile Glu Ala Ile Arg Gln Ala Gly Gln Glu Met 20 25 30Ile Leu Ala 35 356 35 PRT Artificial Sequence Core polypeptide 356Met Leu Asn Ser Gln Ala Ile Asp Asn Leu Arg Ala Ser Leu Glu Thr 1 5 10 15Thr Asn Gln Ala Ile Glu Ala Ile Arg Gln Ala Gly Gln Glu Met Ile 20 25 30Leu Ala Val 35 357 35 PRT Artificial Sequence Core polypeptide 357Leu Asn Ser Gln Ala Ile Asp Asn Leu Arg Ala Ser Leu Glu Thr Thr 1 5 10 15Asn Gln Ala Ile Glu Ala Ile Arg Gln Ala Gly Gln Glu Met Ile Leu 20 25 30Ala Val Gln 35 358 35 PRT Artificial Sequence Core polypeptide 358Asn Ser Gln Ala Ile Asp Asn Leu Arg Ala Ser Leu Glu Thr Thr Asn 1 5 10 15Gln Ala Ile Glu Ala Ile Arg Gln Ala Gly Gln Glu Met Ile Leu Ala 20 25 30Val Gln Gly 35 359 35 PRT Artificial Sequence Core polypeptide 359Ser Gln Ala Ile Asp Asn Leu Arg Ala Ser Leu Glu Thr Thr Asn Gln 1 5 10 15Ala Ile Glu Ala Ile Arg Gln Ala Gly Gln Glu Met Ile Leu Ala Val 20 25 30Gln Gly Val 35 360 35 PRT Artificial Sequence Core polypeptide 360Gln Ala Ile Asp Asn Leu Arg Ala Ser Leu Glu Thr Thr Asn Gln Ala 1 5 10 15Ile Glu Ala Ile Arg Gln Ala Gly Gln Glu Met Ile Leu Ala Val Gln 20 25 30Gly Val Gln 35 361 35 PRT Artificial Sequence Core polypeptide 361Ala Ile Asp Asn Leu Arg Ala Ser Leu Glu Thr Thr Asn Gln Ala Ile 1 5 10 15Glu Ala Ile Arg Gln Ala Gly Gln Glu Met Ile Leu Ala Val Gln Gly 20 25 30Val Gln Asp 35 362 35 PRT Artificial Sequence Core polypeptide 362Ile Asp Asn Leu Arg Ala Ser Leu Glu Thr Thr Asn Gln Ala Ile Glu 1 5 10 15Ala Ile Arg Gln Ala Gly Gln Glu Met Ile Leu Ala Val Gln Gly Val 20 25 30Gln Asp Tyr 35 363 35 PRT Artificial Sequence Core polypeptide 363Asp Asn Leu Arg Ala Ser Leu Glu Thr Thr Asn Gln Ala Ile Glu Ala 1 5 10 15Ile Arg Gln Ala Gly Gln Glu Met Ile Leu Ala Val Gln Gly Val Gln 20 25 30Asp Tyr Ile 35 364 35 PRT Artificial Sequence Core polypeptide 364Asn Leu Arg Ala Ser Leu Glu Thr Thr Asn Gln Ala Ile Glu Ala Ile 1 5 10 15Arg Gln Ala Gly Gln Glu Met Ile Leu Ala Val Gln Gly Val Gln Asp 20 25 30Tyr Ile Asn 35 365 35 PRT Artificial Sequence Core polypeptide 365Leu Arg Ala Ser Leu Glu Thr Thr Asn Gln Ala Ile Glu Ala Ile Arg 1 5 10 15Gln Ala Gly Gln Glu Met Ile Leu Ala Val Gln Gly Val Gln Asp Tyr 20 25 30Ile Asn Asn 35 366 35 PRT Artificial Sequence Core polypeptide 366Arg Ala Ser Leu Glu Thr Thr Asn Gln Ala Ile Glu Ala Ile Arg Gln 1 5 10 15Ala Gly Gln Glu Met Ile Leu Ala Val Gln Gly Val Gln Asp Tyr Ile 20 25 30Asn Asn Glu 35 367 33 PRT Artificial Sequence Core polypeptide 367Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile Lys Glu Asn Lys 1 5 10 15Asn Gly Thr Asp Ala Val Lys Leu Ile Lys Gln Glu Leu Asp Lys Tyr 20 25 30Lys 368 33 PRT Artificial Sequence Core polypeptide 368Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile Lys Glu Asn Lys Asn 1 5 10 15Gly Thr Asp Ala Val Lys Leu Ile Lys Gln Glu Leu Asp Lys Tyr Lys 20 25 30Asn 369 33 PRT Artificial Sequence Core polypeptide 369Ser Val Ile Thr Ile Glu Leu Ser Asn Ile Lys Glu Asn Lys Asn Gly 1 5 10 15Thr Asp Ala Val Lys Leu Ile Lys Gln Glu Leu Asp Lys Tyr Lys Asn 20 25 30Ala 370 34 PRT Artificial Sequence Core polypeptide 370Ser Asn Ile Lys Glu Asn Lys Asn Gly Thr Asp Ala Lys Val Lys Leu 1 5 10 15Ile Lys Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln 20 25 30Leu Leu 371 34 PRT Artificial Sequence Core polypeptide 371Lys Glu Asn Lys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys Gln 1 5 10 15Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu Met 20 25 30Gln Ser 372 15 PRT Artificial Sequence Core polypeptide 372Cys Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe Cys 1 5 10 15 373 15 PRT Artificial Sequence Core polypeptide 373Cys Leu Glu Leu Asp Lys Trp Ala Ser Leu Ala Asn Trp Phe Cys 1 5 10 15 374 15 PRT Artificial Sequence Core polypeptide 374Cys Leu Glu Leu Asp Lys Trp Ala Ser Leu Phe Asn Phe Phe Cys 1 5 10 15 375 36 PRT Artificial Sequence Core polypeptide 375Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Phe Asn Phe Phe 35 376 35 PRT Artificial Sequence Core polypeptide 376Arg Met Lys Gln Leu Glu Asp Lys Val Glu Glu Leu Leu Ser Lys Asn 1 5 10 15Tyr His Leu Glu Asn Glu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp 20 25 30Asn Trp Phe 35 377 28 PRT Artificial Sequence Core polypeptide 377Lys Val Glu Glu Leu Leu Ser Lys Asn Tyr His Leu Glu Asn Glu Leu 1 5 10 15Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe 20 25 378 29 PRT Artificial Sequence Core polypeptide 378Arg Met Lys Gln Leu Glu Asp Lys Val Glu Glu Leu Leu Ser Lys Leu 1 5 10 15Glu Trp Ile Arg Arg Ser Asn Gln Lys Leu Asp Ser Ile 20 25 379 29 PRT Artificial Sequence Core polypeptide 379Arg Met Lys Gln Leu Glu Asp Lys Val Glu Glu Leu Leu Ser Lys Leu 1 5 10 15Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu His Asn Val 20 25 380 28 PRT Artificial Sequence Core polypeptide 380Glu Leu Glu Ala Leu Arg Gly Glu Leu Arg Ala Leu Arg Gly Glu Leu 1 5 10 15Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe 20 25 381 34 PRT Artificial Sequence Core polypeptide 381Leu Asp Pro Ile Asp Ile Ser Ile Glu Leu Asn Lys Ala Lys Ser Asp 1 5 10 15Leu Glu Glu Ser Lys Glu Trp Ile Arg Arg Ser Asn Gln Lys Leu Asp 20 25 30Ser Ile 382 16 PRT Artificial Sequence Core polypeptide 382Cys Asn Glu Gln Leu Ser Asp Ser Phe Pro Val Glu Phe Phe Gln Val 1 5 10 15 383 21 PRT Artificial Sequence Core polypeptide 383Met Ala Glu Asp Asp Pro Tyr Leu Gly Arg Pro Glu Gln Met Phe His 1 5 10 15Leu Asp Pro Ser Leu 20 384 20 PRT Artificial Sequence Core polypeptide 384Glu Asp Phe Ser Ser Ile Ala Asp Met Asp Phe Ser Ala Leu Leu Ser 1 5 10 15Gln Ile Ser Ser 20 385 35 PRT Artificial Sequence Core polypeptide 385Thr Trp Gln Glu Trp Glu Arg Lys Val Asp Phe Leu Glu Glu Asn Ile 1 5 10 15Thr Ala Leu Leu Glu Glu Ala Gln Ile Gln Gln Glu Lys Asn Met Tyr 20 25 30Glu Leu Gln 35 386 35 PRT Artificial Sequence Core polypeptide 386Trp Gln Glu Trp Glu Arg Lys Val Asp Phe Leu Glu Glu Asn Ile Thr 1 5 10 15Ala Leu Leu Glu Glu Ala Gln Ile Gln Gln Glu Lys Asn Met Tyr Glu 20 25 30Leu Gln Lys 35 387 35 PRT Artificial Sequence Core polypeptide 387Gln Glu Trp Glu Arg Lys Val Asp Phe Leu Glu Glu Asn Ile Thr Ala 1 5 10 15Leu Leu Glu Glu Ala Gln Ile Gln Gln Glu Lys Asn Met Tyr Glu Leu 20 25 30Gln Lys Leu 35 388 35 PRT Artificial Sequence Core polypeptide 388Glu Trp Glu Arg Lys Val Asp Phe Leu Glu Glu Asn Ile Thr Ala Leu 1 5 10 15Leu Glu Glu Ala Gln Ile Gln Gln Glu Lys Asn Met Tyr Glu Leu Gln 20 25 30Lys Leu Asn 35 389 35 PRT Artificial Sequence Core polypeptide 389Trp Glu Arg Lys Val Asp Phe Leu Glu Glu Asn Ile Thr Ala Leu Leu 1 5 10 15Glu Glu Ala Gln Ile Gln Gln Glu Lys Asn Met Tyr Glu Leu Gln Lys 20 25 30Leu Asn Ser 35 390 35 PRT Artificial Sequence Core polypeptide 390Glu Arg Lys Val Asp Phe Leu Glu Glu Asn Ile Thr Ala Leu Leu Glu 1 5 10 15Glu Ala Gln Ile Gln Gln Glu Lys Asn Met Tyr Glu Leu Gln Lys Leu 20 25 30Asn Ser Trp 35 391 35 PRT Artificial Sequence Core polypeptide 391Arg Lys Val Asp Phe Leu Glu Glu Asn Ile Thr Ala Leu Leu Glu Glu 1 5 10 15Ala Gln Ile Gln Gln Glu Lys Asn Met Tyr Glu Leu Gln Lys Leu Asn 20 25 30Ser Trp Asp 35 392 35 PRT Artificial Sequence Core polypeptide 392Lys Val Asp Phe Leu Glu Glu Asn Ile Thr Ala Leu Leu Glu Glu Ala 1 5 10 15Gln Ile Gln Gln Glu Lys Asn Met Tyr Glu Leu Gln Lys Leu Asn Ser 20 25 30Trp Asp Val 35 393 35 PRT Artificial Sequence Core polypeptide 393Val Asp Phe Leu Glu Glu Asn Ile Thr Ala Leu Leu Glu Glu Ala Gln 1 5 10 15Ile Gln Gln Glu Lys Asn Met Tyr Glu Leu Gln Lys Leu Asn Ser Trp 20 25 30Asp Val Phe 35 394 35 PRT Artificial Sequence Core polypeptide 394Asp Phe Leu Glu Glu Asn Ile Thr Ala Leu Leu Glu Glu Ala Gln Ile 1 5 10 15Gln Gln Glu Lys Asn Met Tyr Glu Leu Gln Lys Leu Asn Ser Trp Asp 20 25 30Val Phe Gly 35 395 35 PRT Artificial Sequence Core polypeptide 395Phe Leu Glu Glu Asn Ile Thr Ala Leu Leu Glu Glu Ala Gln Ile Gln 1 5 10 15Gln Glu Lys Asn Met Tyr Glu Leu Gln Lys Leu Asn Ser Trp Asp Val 20 25 30Phe Gly Asn 35 396 35 PRT Artificial Sequence Core polypeptide 396Leu Glu Glu Asn Ile Thr Ala Leu Leu Glu Glu Ala Gln Ile Gln Gln 1 5 10 15Glu Lys Asn Met Tyr Glu Leu Gln Lys Leu Asn Ser Trp Asp Val Phe 20 25 30Gly Asn Trp 35 397 36 PRT Artificial Sequence Core polypeptide 397Leu Glu Glu Asn Ile Thr Ala Leu Leu Glu Glu Ala Gln Ile Gln Gln 1 5 10 15Glu Lys Asn Met Tyr Glu Leu Gln Lys Leu Asn Ser Trp Asp Val Phe 20 25 30Gly Asn Trp Phe 35 398 36 PRT Artificial Sequence Core polypeptide 398Asn Glu Gln Ser Glu Glu Lys Glu Asn Glu Leu Tyr Trp Ala Lys Glu 1 5 10 15Gln Leu Leu Asp Leu Leu Phe Asn Ile Phe Asn Gln Thr Val Gly Ala 20 25 30Trp Ile Met Gln 35 399 33 PRT Artificial Sequence Core polypeptide 399Glu Trp Glu Arg Lys Val Asp Phe Leu Glu Glu Asn Ile Thr Ala Leu 1 5 10 15Leu Glu Glu Ala Gln Ile Gln Gln Glu Lys Asn Met Tyr Glu Gly Gly 20 25 30Cys 400 38 PRT Artificial Sequence Core polypeptide 400Gln Gln Gln Leu Leu Asp Val Val Lys Arg Gln Gln Glu Leu Leu Arg 1 5 10 15Leu Thr Val Trp Gly Thr Lys Asn Leu Gln Thr Arg Val Thr Ala Ile 20 25 30Glu Lys Tyr Leu Lys Asp 35 401 38 PRT Artificial Sequence Core polypeptide 401Gln Gln Leu Leu Asp Val Val Lys Arg Gln Gln Glu Leu Leu Arg Leu 1 5 10 15Thr Val Trp Gly Thr Lys Asn Leu Gln Thr Arg Val Thr Ala Ile Glu 20 25 30Lys Tyr Leu Lys Asp Gln 35 402 38 PRT Artificial Sequence Core polypeptide 402Gln Gln Leu Leu Asp Val Val Lys Arg Gln Gln Glu Leu Leu Arg Leu 1 5 10 15Thr Val Trp Gly Pro Lys Asn Leu Gln Thr Arg Val Thr Ala Ile Glu 20 25 30Lys Tyr Leu Lys Asp Gln 35 403 38 PRT Artificial Sequence Core polypeptide 403Asp Glu Arg Lys Gln Asp Lys Val Leu Val Val Gln Gln Thr Gly Thr 1 5 10 15Leu Gln Leu Thr Leu Ile Gln Leu Glu Lys Thr Ala Lys Leu Gln Trp 20 25 30Val Arg Leu Asn Arg Tyr 35 404 35 PRT Artificial Sequence Core polypeptide 404Gln Gln Gln Leu Leu Asp Val Val Lys Arg Gln Gln Glu Leu Leu Arg 1 5 10 15Leu Thr Val Trp Gly Thr Lys Asn Leu Gln Thr Arg Val Thr Ala Ile 20 25 30Glu Lys Tyr 35 405 35 PRT Artificial Sequence Core polypeptide 405Gln Gln Leu Leu Asp Val Val Lys Arg Gln Gln Glu Leu Leu Arg Leu 1 5 10 15Thr Val Trp Gly Thr Lys Asn Leu Gln Thr Arg Val Thr Ala Ile Glu 20 25 30Lys Tyr Leu 35 406 35 PRT Artificial Sequence Core polypeptide 406Gln Leu Leu Asp Val Val Lys Arg Gln Gln Glu Leu Leu Arg Leu Thr 1 5 10 15Val Trp Gly Thr Lys Asn Leu Gln Thr Arg Val Thr Ala Ile Glu Lys 20 25 30Tyr Leu Lys 35 407 35 PRT Artificial Sequence Core polypeptide 407Leu Leu Asp Val Val Lys Arg Gln Gln Glu Leu Leu Arg Leu Thr Val 1 5 10 15Trp Gly Thr Lys Asn Leu Gln Thr Arg Val Thr Ala Ile Glu Lys Tyr 20 25 30Leu Lys Asp 35 408 35 PRT Artificial Sequence Core polypeptide 408Leu Asp Val Val Lys Arg Gln Gln Glu Leu Leu Arg Leu Thr Val Trp 1 5 10 15Gly Thr Lys Asn Leu Gln Thr Arg Val Thr Ala Ile Glu Lys Tyr Leu 20 25 30Lys Asp Gln 35 409 35 PRT Artificial Sequence Core polypeptide 409Asp Val Val Lys Arg Gln Gln Glu Leu Leu Arg Leu Thr Val Trp Gly 1 5 10 15Thr Lys Asn Leu Gln Thr Arg Val Thr Ala Ile Glu Lys Tyr Leu Lys 20 25 30Asp Gln Ala 35 410 35 PRT Artificial Sequence Core polypeptide 410Val Val Lys Arg Gln Gln Glu Leu Leu Arg Leu Thr Val Trp Gly Thr 1 5 10 15Lys Asn Leu Gln Thr Arg Val Thr Ala Ile Glu Lys Tyr Leu Lys Asp 20 25 30Gln Ala Gln 35 411 35 PRT Artificial Sequence Core polypeptide 411Val Lys Arg Gln Gln Glu Leu Leu Arg Leu Thr Val Trp Gly Thr Lys 1 5 10 15Asn Leu Gln Thr Arg Val Thr Ala Ile Glu Lys Tyr Leu Lys Asp Gln 20 25 30Ala Gln Leu 35 412 35 PRT Artificial Sequence Core polypeptide 412Lys Arg Gln Gln Glu Leu Leu Arg Leu Thr Val Trp Gly Thr Lys Asn 1 5 10 15Leu Gln Thr Arg Val Thr Ala Ile Glu Lys Tyr Leu Lys Asp Gln Ala 20 25 30Gln Leu Asn 35 413 35 PRT Artificial Sequence Core polypeptide 413Arg Gln Gln Glu Leu Leu Arg Leu Thr Val Trp Gly Thr Lys Asn Leu 1 5 10 15Gln Thr Arg Val Thr Ala Ile Glu Lys Tyr Leu Lys Asp Gln Ala Gln 20 25 30Leu Asn Ala 35 414 35 PRT Artificial Sequence Core polypeptide 414Gln Gln Glu Leu Leu Arg Leu Thr Val Trp Gly Thr Lys Asn Leu Gln 1 5 10 15Thr Arg Val Thr Ala Ile Glu Lys Tyr Leu Lys Asp Gln Ala Gln Leu 20 25 30Asn Ala Trp 35 415 35 PRT Artificial Sequence Core polypeptide 415Gln Glu Leu Leu Arg Leu Thr Val Trp Gly Thr Lys Asn Leu Gln Thr 1 5 10 15Arg Val Thr Ala Ile Glu Lys Tyr Leu Lys Asp Gln Ala Gln Leu Asn 20 25 30Ala Trp Gly 35 416 35 PRT Artificial Sequence Core polypeptide 416Glu Leu Leu Arg Leu Thr Val Trp Gly Thr Lys Asn Leu Gln Thr Arg 1 5 10 15Val Thr Ala Ile Glu Lys Tyr Leu Lys Asp Gln Ala Gln Leu Asn Ala 20 25 30Trp Gly Cys 35 417 38 PRT Artificial Sequence Core polypeptide 417Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu 1 5 10 15Thr Val Trp Gly Pro Lys Gln Leu Gln Ala Arg Ile Leu Ala Val Glu 20 25 30Arg Tyr Leu Lys Asp Gln 35 418 35 PRT Artificial Sequence Core polypeptide 418Ser Glu Leu Glu Ile Lys Arg Tyr Lys Asn Arg Val Ala Ser Arg Lys 1 5 10 15Cys Arg Ala Lys Phe Lys Gln Leu Leu Gln His Tyr Arg Glu Val Ala 20 25 30Ala Ala Lys 35 419 35 PRT Artificial Sequence Core polypeptide 419Glu Leu Glu Ile Lys Arg Tyr Lys Asn Arg Val Ala Ser Arg Lys Cys 1 5 10 15Arg Ala Lys Phe Lys Gln Leu Leu Gln His Tyr Arg Glu Val Ala Ala 20 25 30Ala Lys Ser 35 420 35 PRT Artificial Sequence Core polypeptide 420Leu Glu Ile Lys Arg Tyr Lys Asn Arg Val Ala Ser Arg Lys Cys Arg 1 5 10 15Ala Lys Phe Lys Gln Leu Leu Gln His Tyr Arg Glu Val Ala Ala Ala 20 25 30Lys Ser Ser 35 421 35 PRT Artificial Sequence Core polypeptide 421Glu Ile Lys Arg Tyr Lys Asn Arg Val Ala Ser Arg Lys Cys Arg Ala 1 5 10 15Lys Phe Lys Gln Leu Leu Gln His Tyr Arg Glu Val Ala Ala Ala Lys 20 25 30Ser Ser Glu 35 422 35 PRT Artificial Sequence Core polypeptide 422Ile Lys Arg Tyr Lys Asn Arg Val Ala Ser Arg Lys Cys Arg Ala Lys 1 5 10 15Phe Lys Gln Leu Leu Gln His Tyr Arg Glu Val Ala Ala Ala Lys Ser 20 25 30Ser Glu Asn 35 423 35 PRT Artificial Sequence Core polypeptide 423Lys Arg Tyr Lys Asn Arg Val Ala Ser Arg Lys Cys Arg Ala Lys Phe 1 5 10 15Lys Gln Leu Leu Gln His Tyr Arg Glu Val Ala Ala Ala Lys Ser Ser 20 25 30Glu Asn Asp 35 424 35 PRT Artificial Sequence Core polypeptide 424Arg Tyr Lys Asn Arg Val Ala Ser Arg Lys Cys Arg Ala Lys Phe Lys 1 5 10 15Gln Leu Leu Gln His Tyr Arg Glu Val Ala Ala Ala Lys Ser Ser Glu 20 25 30Asn Asp Arg 35 425 35 PRT Artificial Sequence Core polypeptide 425Tyr Lys Asn Arg Val Ala Ser Arg Lys Cys Arg Ala Lys Phe Lys Gln 1 5 10 15Leu Leu Gln His Tyr Arg Glu Val Ala Ala Ala Lys Ser Ser Glu Asn 20 25 30Asp Arg Leu 35 426 35 PRT Artificial Sequence Core polypeptide 426Lys Asn Arg Val Ala Ser Arg Lys Cys Arg Ala Lys Phe Lys Gln Leu 1 5 10 15Leu Gln His Tyr Arg Glu Val Ala Ala Ala Lys Ser Ser Glu Asn Asp 20 25 30Arg Leu Arg 35 427 35 PRT Artificial Sequence Core polypeptide 427Asn Arg Val Ala Ser Arg Lys Cys Arg Ala Lys Phe Lys Gln Leu Leu 1 5 10 15Gln His Tyr Arg Glu Val Ala Ala Ala Lys Ser Ser Glu Asn Asp Arg 20 25 30Leu Arg Leu 35 428 35 PRT Artificial Sequence Core polypeptide 428Arg Val Ala Ser Arg Lys Cys Arg Ala Lys Phe Lys Gln Leu Leu Gln 1 5 10 15His Tyr Arg Glu Val Ala Ala Ala Lys Ser Ser Glu Asn Asp Arg Leu 20 25 30Arg Leu Leu 35 429 35 PRT Artificial Sequence Core polypeptide 429Val Ala Ser Arg Lys Cys Arg Ala Lys Phe Lys Gln Leu Leu Gln His 1 5 10 15Tyr Arg Glu Val Ala Ala Ala Lys Ser Ser Glu Asn Asp Arg Leu Arg 20 25 30Leu Leu Leu 35 430 35 PRT Artificial Sequence Core polypeptide 430Ala Ser Arg Lys Cys Arg Ala Lys Phe Lys Gln Leu Leu Gln His Tyr 1 5 10 15Arg Glu Val Ala Ala Ala Lys Ser Ser Glu Asn Asp Arg Leu Arg Leu 20 25 30Leu Leu Lys 35 431 35 PRT Artificial Sequence Core polypeptide 431Ser Arg Lys Cys Arg Ala Lys Phe Lys Gln Leu Leu Gln His Tyr Arg 1 5 10 15Glu Val Ala Ala Ala Lys Ser Ser Glu Asn Asp Arg Leu Arg Leu Leu 20 25 30Leu Lys Gln 35 432 35 PRT Artificial Sequence Core polypeptide 432Arg Lys Cys Arg Ala Lys Phe Lys Gln Leu Leu Gln His Tyr Arg Glu 1 5 10 15Val Ala Ala Ala Lys Ser Ser Glu Asn Asp Arg Leu Arg Leu Leu Leu 20 25 30Lys Gln Met 35 433 35 PRT Artificial Sequence Core polypeptide 433Lys Cys Arg Ala Lys Phe Lys Gln Leu Leu Gln His Tyr Arg Glu Val 1 5 10 15Ala Ala Ala Lys Ser Ser Glu Asn Asp Arg Leu Arg Leu Leu Leu Lys 20 25 30Gln Met Cys 35 434 35 PRT Artificial Sequence Core polypeptide 434Cys Arg Ala Lys Phe Lys Gln Leu Leu Gln His Tyr Arg Glu Val Ala 1 5 10 15Ala Ala Lys Ser Ser Glu Asn Asp Arg Leu Arg Leu Leu Leu Lys Gln 20 25 30Met Cys Pro 35 435 35 PRT Artificial Sequence Core polypeptide 435Arg Ala Lys Phe Lys Gln Leu Leu Gln His Tyr Arg Glu Val Ala Ala 1 5 10 15Ala Lys Ser Ser Glu Asn Asp Arg Leu Arg Leu Leu Leu Lys Gln Met 20 25 30Cys Pro Ser 35 436 35 PRT Artificial Sequence Core polypeptide 436Ala Lys Phe Lys Gln Leu Leu Gln His Tyr Arg Glu Val Ala Ala Ala 1 5 10 15Lys Ser Ser Glu Asn Asp Arg Leu Arg Leu Leu Leu Lys Gln Met Cys 20 25 30Pro Ser Leu 35 437 35 PRT Artificial Sequence Core polypeptide 437Lys Phe Lys Gln Leu Leu Gln His Tyr Arg Glu Val Ala Ala Ala Lys 1 5 10 15Ser Ser Glu Asn Asp Arg Leu Arg Leu Leu Leu Lys Gln Met Cys Pro 20 25 30Ser Leu Asp 35 438 35 PRT Artificial Sequence Core polypeptide 438Phe Lys Gln Leu Leu Gln His Tyr Arg Glu Val Ala Ala Ala Lys Ser 1 5 10 15Ser Glu Asn Asp Arg Leu Arg Leu Leu Leu Lys Gln Met Cys Pro Ser 20 25 30Leu Asp Val 35 439 35 PRT Artificial Sequence Core polypeptide 439Lys Gln Leu Leu Gln His Tyr Arg Glu Val Ala Ala Ala Lys Ser Ser 1 5 10 15Glu Asn Asp Arg Leu Arg Leu Leu Leu Lys Gln Met Cys Pro Ser Leu 20 25 30Asp Val Asp 35 440 35 PRT Artificial Sequence Core polypeptide 440Gln Leu Leu Gln His Tyr Arg Glu Val Ala Ala Ala Lys Ser Ser Glu 1 5 10 15Asn Asp Arg Leu Arg Leu Leu Leu Lys Gln Met Cys Pro Ser Leu Asp 20 25 30Val Asp Ser 35 441 35 PRT Artificial Sequence Core polypeptide 441Leu Leu Gln His Tyr Arg Glu Val Ala Ala Ala Lys Ser Ser Glu Asn 1 5 10 15Asp Arg Leu Arg Leu Leu Leu Lys Gln Met Cys Pro Ser Leu Asp Val 20 25 30Asp Ser Ile 35 442 35 PRT Artificial Sequence Core polypeptide 442Leu Gln His Tyr Arg Glu Val Ala Ala Ala Lys Ser Ser Glu Asn Asp 1 5 10 15Arg Leu Arg Leu Leu Leu Lys Gln Met Cys Pro Ser Leu Asp Val Asp 20 25 30Ser Ile Ile 35 443 35 PRT Artificial Sequence Core polypeptide 443Gln His Tyr Arg Glu Val Ala Ala Ala Lys Ser Ser Glu Asn Asp Arg 1 5 10 15Leu Arg Leu Leu Leu Lys Gln Met Cys Pro Ser Leu Asp Val Asp Ser 20 25 30Ile Ile Pro 35 444 35 PRT Artificial Sequence Core polypeptide 444His Tyr Arg Glu Val Ala Ala Ala Lys Ser Ser Glu Asn Asp Arg Leu 1 5 10 15Arg Leu Leu Leu Lys Gln Met Cys Pro Ser Leu Asp Val Asp Ser Ile 20 25 30Ile Pro Arg 35 445 35 PRT Artificial Sequence Core polypeptide 445Tyr Arg Glu Val Ala Ala Ala Lys Ser Ser Glu Asn Asp Arg Leu Arg 1 5 10 15Leu Leu Leu Lys Gln Met Cys Pro Ser Leu Asp Val Asp Ser Ile Ile 20 25 30Pro Arg Thr 35 446 35 PRT Artificial Sequence Core polypeptide 446Arg Glu Val Ala Ala Ala Lys Ser Ser Glu Asn Asp Arg Leu Arg Leu 1 5 10 15Leu Leu Lys Gln Met Cys Pro Ser Leu Asp Val Asp Ser Ile Ile Pro 20 25 30Arg Thr Pro 35 447 35 PRT Artificial Sequence Core polypeptide 447Glu Val Ala Ala Ala Lys Ser Ser Glu Asn Asp Arg Leu Arg Leu Leu 1 5 10 15Leu Lys Gln Met Cys Pro Ser Leu Asp Val Asp Ser Ile Ile Pro Arg 20 25 30Thr Pro Asp 35 448 35 PRT Artificial Sequence Core polypeptide 448Val Ala Ala Ala Lys Ser Ser Glu Asn Asp Arg Leu Arg Leu Leu Leu 1 5 10 15Lys Gln Met Cys Pro Ser Leu Asp Val Asp Ser Ile Ile Pro Arg Thr 20 25 30Pro Asp Val 35 449 35 PRT Artificial Sequence Core polypeptide 449Ala Ala Ala Lys Ser Ser Glu Asn Asp Arg Leu Arg Leu Leu Leu Lys 1 5 10 15Gln Met Cys Pro Ser Leu Asp Val Asp Ser Ile Ile Pro Arg Thr Pro 20 25 30Asp Val Leu 35 450 35 PRT Artificial Sequence Core polypeptide 450Ala Ala Lys Ser Ser Glu Asn Asp Arg Leu Arg Leu Leu Leu Lys Gln 1 5 10 15Met Cys Pro Ser Leu Asp Val Asp Ser Ile Ile Pro Arg Thr Pro Asp 20 25 30Val Leu His 35 451 35 PRT Artificial Sequence Core polypeptide 451Ala Lys Ser Ser Glu Asn Asp Arg Leu Arg Leu Leu Leu Lys Gln Met 1 5 10 15Cys Pro Ser Leu Asp Val Asp Ser Ile Ile Pro Arg Thr Pro Asp Val 20 25 30Leu His Glu 35 452 35 PRT Artificial Sequence Core polypeptide 452Lys Ser Ser Glu Asn Asp Arg Leu Arg Leu Leu Leu Lys Gln Met Cys 1 5 10 15Pro Ser Leu Asp Val Asp Ser Ile Ile Pro Arg Thr Pro Asp Val Leu 20 25 30His Glu Asp 35 453 35 PRT Artificial Sequence Core polypeptide 453Ser Ser Glu Asn Asp Arg Leu Arg Leu Leu Leu Lys Gln Met Cys Pro 1 5 10 15Ser Leu Asp Val Asp Ser Ile Ile Pro Arg Thr Pro Asp Val Leu His 20 25 30Glu Asp Leu 35 454 35 PRT Artificial Sequence Core polypeptide 454Ser Glu Asn Asp Arg Leu Arg Leu Leu Leu Lys Gln Met Cys Pro Ser 1 5 10 15Leu Asp Val Asp Ser Ile Ile Pro Arg Thr Pro Asp Val Leu His Glu 20 25 30Asp Leu Leu 35 455 35 PRT Artificial Sequence Core polypeptide 455Glu Asn Asp Arg Leu Arg Leu Leu Leu Lys Gln Met Cys Pro Ser Leu 1 5 10 15Asp Val Asp Ser Ile Ile Pro Arg Thr Pro Asp Val Leu His Glu Asp 20 25 30Leu Leu Asn 35 456 35 PRT Artificial Sequence Core polypeptide 456Asn Asp Arg Leu Arg Leu Leu Leu Lys Gln Met Cys Pro Ser Leu Asp 1 5 10 15Val Asp Ser Ile Ile Pro Arg Thr Pro Asp Val Leu His Glu Asp Leu 20 25 30Leu Asn Phe 35 457 35 PRT Artificial Sequence Core polypeptide 457Ala Ala Gly Ser Thr Met Gly Ala Arg Ser Met Thr Leu Thr Val Gln 1 5 10 15Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu Leu 20 25 30Arg Ala Ile 35 458 35 PRT Artificial Sequence Core polypeptide 458Pro Gly Tyr Arg Trp Met Cys Leu Arg Arg Phe Ile Ile Phe Leu Phe 1 5 10 15Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu Val Leu Leu Asp Tyr Gln 20 25 30Gly Met Leu 35 459 35 PRT Artificial Sequence Core polypeptide 459Gly Tyr Arg Trp Met Cys Leu Arg Arg Phe Ile Ile Phe Leu Phe Ile 1 5 10 15Leu Leu Leu Cys Leu Ile Phe Leu Leu Val Leu Leu Asp Tyr Gln Gly 20 25 30Met Leu Pro 35 460 35 PRT Artificial Sequence Core polypeptide 460Tyr Arg Trp Met Cys Leu Arg Arg Phe Ile Ile Phe Leu Phe Ile Leu 1 5 10 15Leu Leu Cys Leu Ile Phe Leu Leu Val Leu Leu Asp Tyr Gln Gly Met 20 25 30Leu Pro Val 35 461 35 PRT Artificial Sequence Core polypeptide 461Arg Trp Met Cys Leu Arg Arg Phe Ile Ile Phe Leu Phe Ile Leu Leu 1 5 10 15Leu Cys Leu Ile Phe Leu Leu Val Leu Leu Asp Tyr Gln Gly Met Leu 20 25 30Pro Val Cys 35 462 35 PRT Artificial Sequence Core polypeptide 462Trp Met Cys Leu Arg Arg Phe Ile Ile Phe Leu Phe Ile Leu Leu Leu 1 5 10 15Cys Leu Ile Phe Leu Leu Val Leu Leu Asp Tyr Gln Gly Met Leu Pro 20 25 30Val Cys Pro 35 463 35 PRT Artificial Sequence Core polypeptide 463Met Cys Leu Arg Arg Phe Ile Ile Phe Leu Phe Ile Leu Leu Leu Cys 1 5 10 15Leu Ile Phe Leu Leu Val Leu Leu Asp Tyr Gln Gly Met Leu Pro Val 20 25 30Cys Pro Leu 35 464 35 PRT Artificial Sequence Core polypeptide 464Cys Leu Arg Arg Phe Ile Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu 1 5 10 15Ile Phe Leu Leu Val Leu Leu Asp Tyr Gln Gly Met Leu Pro Val Cys 20 25 30Pro Leu Ile 35 465 35 PRT Artificial Sequence Core polypeptide 465Leu Arg Arg Phe Ile Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile 1 5 10 15Phe Leu Leu Val Leu Leu Asp Tyr Gln Gly Met Leu Pro Val Cys Pro 20 25 30Leu Ile Pro 35 466 35 PRT Artificial Sequence Core polypeptide 466Arg Arg Phe Ile Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe 1 5 10 15Leu Leu Val Leu Leu Asp Tyr Gln Gly Met Leu Pro Val Cys Pro Leu 20 25 30Ile Pro Gly 35 467 35 PRT Artificial Sequence Core polypeptide 467Arg Phe Ile Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe Leu 1 5 10 15Leu Val Leu Leu Asp Tyr Gln Gly Met Leu Pro Val Cys Pro Leu Ile 20 25 30Pro Gly Ser 35 468 35 PRT Artificial Sequence Core polypeptide 468Phe Ile Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu 1 5 10 15Val Leu Leu Asp Tyr Gln Gly Met Leu Pro Val Cys Pro Leu Ile Pro 20 25 30Gly Ser Ser 35 469 35 PRT Artificial Sequence Core polypeptide 469Ile Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu Val 1 5 10 15Leu Leu Asp Tyr Gln Gly Met Leu Pro Val Cys Pro Leu Ile Pro Gly 20 25 30Ser Ser Thr 35 470 35 PRT Artificial Sequence Core polypeptide 470Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu Val Leu 1 5 10 15Leu Asp Tyr Gln Gly Met Leu Pro Val Cys Pro Leu Ile Pro Gly Ser 20 25 30Ser Thr Thr 35 471 35 PRT Artificial Sequence Core polypeptide 471Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu Val Leu Leu 1 5 10 15Asp Tyr Gln Gly Met Leu Pro Val Cys Pro Leu Ile Pro Gly Ser Ser 20 25 30Thr Thr Ser 35 472 35 PRT Artificial Sequence Core polypeptide 472Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu Val Leu Leu Asp 1 5 10 15Tyr Gln Gly Met Leu Pro Val Cys Pro Leu Ile Pro Gly Ser Ser Thr 20 25 30Thr Ser Thr 35 473 35 PRT Artificial Sequence Core polypeptide 473Phe Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu Val Leu Leu Asp Tyr 1 5 10 15Gln Gly Met Leu Pro Val Cys Pro Leu Ile Pro Gly Ser Ser Thr Thr 20 25 30Ser Thr Gly 35 474 35 PRT Artificial Sequence Core polypeptide 474Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu Val Leu Leu Asp Tyr Gln 1 5 10 15Gly Met Leu Pro Val Cys Pro Leu Ile Pro Gly Ser Ser Thr Thr Ser 20 25 30Thr Gly Pro 35 475 35 PRT Artificial Sequence Core polypeptide 475Leu Leu Leu Cys Leu Ile Phe Leu Leu Val Leu Leu Asp Tyr Gln Gly 1 5 10 15Met Leu Pro Val Cys Pro Leu Ile Pro Gly Ser Ser Thr Thr Ser Thr 20 25 30Gly Pro Cys 35 476 35 PRT Artificial Sequence Core polypeptide 476Leu Leu Cys Leu Ile Phe Leu Leu Val Leu Leu Asp Tyr Gln Gly Met 1 5 10 15Leu Pro Val Cys Pro Leu Ile Pro Gly Ser Ser Thr Thr Ser Thr Gly 20 25 30Pro Cys Arg 35 477 35 PRT Artificial Sequence Core polypeptide 477Leu Cys Leu Ile Phe Leu Leu Val Leu Leu Asp Tyr Gln Gly Met Leu 1 5 10 15Pro Val Cys Pro Leu Ile Pro Gly Ser Ser Thr Thr Ser Thr Gly Pro 20 25 30Cys Arg Thr 35 478 35 PRT Artificial Sequence Core polypeptide 478Cys Leu Ile Phe Leu Leu Val Leu Leu Asp Tyr Gln Gly Met Leu Pro 1 5 10 15Val Cys Pro Leu Ile Pro Gly Ser Ser Thr Thr Ser Thr Gly Pro Cys 20 25 30Arg Thr Cys 35 479 35 PRT Artificial Sequence Core polypeptide 479Leu Ile Phe Leu Leu Val Leu Leu Asp Tyr Gln Gly Met Leu Pro Val 1 5 10 15Cys Pro Leu Ile Pro Gly Ser Ser Thr Thr Ser Thr Gly Pro Cys Arg 20 25 30Thr Cys Met 35 480 35 PRT Artificial Sequence Core polypeptide 480Ile Phe Leu Leu Val Leu Leu Asp Tyr Gln Gly Met Leu Pro Val Cys 1 5 10 15Pro Leu Ile Pro Gly Ser Ser Thr Thr Ser Thr Gly Pro Cys Arg Thr 20 25 30Cys Met Thr 35 481 35 PRT Artificial Sequence Core polypeptide 481Phe Leu Leu Val Leu Leu Asp Tyr Gln Gly Met Leu Pro Val Cys Pro 1 5 10 15Leu Ile Pro Gly Ser Ser Thr Thr Ser Thr Gly Pro Cys Arg Thr Cys 20 25 30Met Thr Thr 35 482 35 PRT Artificial Sequence Core polypeptide 482Pro Leu Leu Val Leu Gln Ala Gly Phe Phe Leu Leu Thr Arg Ile Leu 1 5 10 15Thr Ile Pro Gln Ser Leu Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu 20 25 30Gly Gly Thr 35 483 35 PRT Artificial Sequence Core polypeptide 483Leu Leu Val Leu Gln Ala Gly Phe Phe Leu Leu Thr Arg Ile Leu Thr 1 5 10 15Ile Pro Gln Ser Leu Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly 20 25 30Gly Thr Thr 35 484 35 PRT Artificial Sequence Core polypeptide 484Leu Val Leu Gln Ala Gly Phe Phe Leu Leu Thr Arg Ile Leu Thr Ile 1 5 10 15Pro Gln Ser Leu Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly Gly 20 25 30Thr Thr Val 35 485 35 PRT Artificial Sequence Core polypeptide 485Val Leu Gln Ala Gly Phe Phe Leu Leu Thr Arg Ile Leu Thr Ile Pro 1 5 10 15Gln Ser Leu Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly Gly Thr 20 25 30Thr Val Cys 35 486 35 PRT Artificial Sequence Core polypeptide 486Leu Gln Ala Gly Phe Phe Leu Leu Thr Arg Ile Leu Thr Ile Pro Gln 1 5 10 15Ser Leu Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly Gly Thr Thr 20 25 30Val Cys Leu 35 487 35 PRT Artificial Sequence Core polypeptide 487Gln Ala Gly Phe Phe Leu Leu Thr Arg Ile Leu Thr Ile Pro Gln Ser 1 5 10 15Leu Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly Gly Thr Thr Val 20 25 30Cys Leu Gly 35 488 35 PRT Artificial Sequence Core polypeptide 488Ala Gly Phe Phe Leu Leu Thr Arg Ile Leu Thr Ile Pro Gln Ser Leu 1 5 10 15Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly Gly Thr Thr Val Cys 20 25 30Leu Gly Gln 35 489 35 PRT Artificial Sequence Core polypeptide 489Gly Phe Phe Leu Leu Thr Arg Ile Leu Thr Ile Pro Gln Ser Leu Asp 1 5 10 15Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly Gly Thr Thr Val Cys Leu 20 25 30Gly Gln Asn 35 490 35 PRT Artificial Sequence Core polypeptide 490Phe Phe Leu Leu Thr Arg Ile Leu Thr Ile Pro Gln Ser Leu Asp Ser 1 5 10 15Trp Trp Thr Ser Leu Asn Phe Leu Gly Gly Thr Thr Val Cys Leu Gly 20 25 30Gln Asn Ser 35 491 35 PRT Artificial Sequence Core polypeptide 491Phe Leu Leu Thr Arg Ile Leu Thr Ile Pro Gln Ser Leu Asp Ser Trp 1 5 10 15Trp Thr Ser Leu Asn Phe Leu Gly Gly Thr Thr Val Cys Leu Gly Gln 20 25 30Asn Ser Gln 35 492 35 PRT Artificial Sequence Core polypeptide 492Leu Leu Thr Arg Ile Leu Thr Ile Pro Gln Ser Leu Asp Ser Trp Trp 1 5 10 15Thr Ser Leu Asn Phe Leu Gly Gly Thr Thr Val Cys Leu Gly Gln Asn 20 25 30Ser Gln Ser 35 493 35 PRT Artificial Sequence Core polypeptide 493Leu Thr Arg Ile Leu Thr Ile Pro Gln Ser Leu Asp Ser Trp Trp Thr 1 5 10 15Ser Leu Asn Phe Leu Gly Gly Thr Thr Val Cys Leu Gly Gln Asn Ser 20 25 30Gln Ser Pro 35 494 28 PRT Artificial Sequence Core polypeptide 494Phe Trp Asn Trp Leu Ser Ala Trp Lys Asp Leu Glu Leu Lys Ser Leu 1 5 10 15Leu Glu Glu Val Lys Asp Glu Leu Gln Lys Met Arg 20 25 495 19 PRT Artificial Sequence Core polypeptide 495Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu 1 5 10 15Thr Val Trp 496 41 PRT Artificial Sequence Core polypeptide 496Cys Gly Gly Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu 1 5 10 15Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Ile Leu 20 25 30Ala Val Glu Arg Tyr Leu Lys Asp Gln 35 40 497 36 PRT Artificial Sequence Core polypeptide 497Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Asn Trp Phe 35 498 36 PRT Artificial Sequence Core polypeptide 498Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Asn Trp Phe 35 499 35 PRT Artificial Sequence Core polypeptide 499Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu Arg Thr Gly Trp Tyr Thr 1 5 10 15Ser Val Ile Thr Ile Glu Leu Ser Asn Ile Lys Glu Asn Lys Asn Gly 20 25 30Thr Asp Ala 35 500 36 PRT Artificial Sequence Core polypeptide 500Ser Ile Ser Asn Ile Glu Thr Val Ile Glu Phe Gln Gln Lys Asn Asn 1 5 10 15Arg Leu Leu Glu Ile Thr Arg Glu Phe Ser Val Asn Ala Gly Val Thr 20 25 30Thr Pro Val Ser 35 501 35 PRT Artificial Sequence Core polypeptide 501Asp Gln Gln Ile Lys Gln Tyr Lys Arg Leu Leu Asp Arg Leu Ile Ile 1 5 10 15Pro Leu Tyr Asp Gly Leu Arg Gln Lys Asp Val Ile Val Ser Asn Gln 20 25 30Glu Ser Asn 35 502 36 PRT Artificial Sequence Core polypeptide 502Tyr Ser Glu Leu Thr Asn Ile Phe Gly Asp Asn Ile Gly Ser Leu Gln 1 5 10 15Glu Lys Gly Ile Lys Leu Gln Gly Ile Ala Ser Leu Tyr Arg Thr Asn 20 25 30Ile Thr Glu Ile 35 503 36 PRT Artificial Sequence Core polypeptide 503Thr Ser Ile Thr Leu Gln Val Arg Leu Pro Leu Leu Thr Arg Leu Leu 1 5 10 15Asn Thr Gln Ile Tyr Arg Val Asp Ser Ile Ser Tyr Asn Ile Gln Asn 20 25 30Arg Glu Trp Tyr 35 504 35 PRT Artificial Sequence Core polypeptide 504Val Glu Ile Ala Glu Tyr Arg Arg Leu Leu Arg Thr Val Leu Glu Pro 1 5 10 15Ile Arg Asp Ala Leu Asn Ala Met Thr Gln Asn Ile Arg Pro Val Gln 20 25 30Ser Val Ala 35 505 36 PRT Artificial Sequence Core polypeptide 505Ser Tyr Phe Ile Val Leu Ser Ile Ala Tyr Pro Thr Leu Ser Glu Ile 1 5 10 15Lys Gly Val Ile Val His Arg Leu Glu Gly Val Ser Tyr Asn Ile Gly 20 25 30Ser Gln Glu Trp 35 506 28 PRT Artificial Sequence Core polypeptide 506Leu Lys Glu Ala Ile Arg Asp Thr Asn Lys Ala Val Gln Ser Val Gln 1 5 10 15Ser Ser Ile Gly Asn Leu Ile Val Ala Ile Lys Ser 20 25 507 38 PRT Artificial Sequence Core polypeptide 507Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu 1 5 10 15Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala Val Glu 20 25 30Arg Tyr Leu Lys Asp Gln 35 508 16 PRT Artificial Sequence Core polypeptide 508Gln Lys Gln Glu Pro Ile Asp Lys Glu Leu Tyr Pro Leu Thr Ser Leu 1 5 10 15 509 14 PRT Artificial Sequence Core polypeptide 509Tyr Pro Lys Phe Val Lys Gln Asn Thr Leu Lys Leu Ala Thr 1 5 10 510 14 PRT Artificial Sequence Core polypeptide 510Gln Tyr Ile Lys Ala Asn Gln Lys Phe Ile Gly Ile Thr Glu 1 5 10 511 14 PRT Artificial Sequence Core polypeptide 511Asn Gly Gln Ile Gly Asn Asp Pro Asn Arg Asp Ile Leu Tyr 1 5 10 512 6 PRT Artificial Sequence Core polypeptide 512Arg Pro Asp Val Tyr His 1 5 513 15 PRT Artificial Sequence Core polypeptide 513Cys Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe Cys 1 5 10 15 514 15 PRT Artificial Sequence Core polypeptide 514Cys Leu Glu Leu Asp Lys Trp Ala Ser Leu Ala Asn Trp Phe Cys 1 5 10 15 515 15 PRT Artificial Sequence Core polypeptide 515Cys Leu Glu Leu Asp Lys Trp Ala Ser Leu Ala Asn Phe Phe Cys 1 5 10 15 516 39 PRT Artificial Sequence Core polypeptide 516Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln Gln His Leu Leu Gln 1 5 10 15Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala Val 20 25 30Glu Arg Tyr Leu Lys Asp Gln 35 517 39 PRT Artificial Sequence Core polypeptide 517Cys Gly Gly Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln 1 5 10 15Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp 20 25 30Ala Ser Leu Trp Asn Trp Phe 35 518 35 PRT Artificial Sequence Core polypeptide 518Pro Leu Leu Val Leu Gln Ala Gly Phe Phe Leu Leu Thr Arg Ile Leu 1 5 10 15Thr Ile Pro Gln Ser Leu Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu 20 25 30Gly Gly Thr 35 519 35 PRT Artificial Sequence Core polypeptide 519Leu Leu Val Leu Gln Ala Gly Phe Phe Leu Leu Thr Arg Ile Leu Thr 1 5 10 15Ile Pro Gln Ser Leu Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly 20 25 30Gly Thr Thr 35 520 35 PRT Artificial Sequence Core polypeptide 520Leu Val Leu Gln Ala Gly Phe Phe Leu Leu Thr Arg Ile Leu Thr Ile 1 5 10 15Pro Gln Ser Leu Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly Gly 20 25 30Thr Thr Val 35 521 35 PRT Artificial Sequence Core polypeptide 521Val Leu Gln Ala Gly Phe Phe Leu Leu Thr Arg Ile Leu Thr Ile Pro 1 5 10 15Gln Ser Leu Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly Gly Thr 20 25 30Thr Val Cys 35 522 35 PRT Artificial Sequence Core polypeptide 522Leu Gln Ala Gly Phe Phe Leu Leu Thr Arg Ile Leu Thr Ile Pro Gln 1 5 10 15Ser Leu Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly Gly Thr Thr 20 25 30Val Cys Leu 35 523 35 PRT Artificial Sequence Core polypeptide 523Gln Ala Gly Phe Phe Leu Leu Thr Arg Ile Leu Thr Ile Pro Gln Ser 1 5 10 15Leu Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly Gly Thr Thr Val 20 25 30Cys Leu Gly 35 524 35 PRT Artificial Sequence Core polypeptide 524Ala Gly Phe Phe Leu Leu Thr Arg Ile Leu Thr Ile Pro Gln Ser Leu 1 5 10 15Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly Gly Thr Thr Val Cys 20 25 30Leu Gly Gln 35 525 35 PRT Artificial Sequence Core polypeptide 525Gly Phe Phe Leu Leu Thr Arg Ile Leu Thr Ile Pro Gln Ser Leu Asp 1 5 10 15Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly Gly Thr Thr Val Cys Leu 20 25 30Gly Gln Asn 35 526 35 PRT Artificial Sequence Core polypeptide 526Phe Phe Leu Leu Thr Arg Ile Leu Thr Ile Pro Gln Ser Leu Asp Ser 1 5 10 15Trp Trp Thr Ser Leu Asn Phe Leu Gly Gly Thr Thr Val Cys Leu Gly 20 25 30Gln Asn Ser 35 527 35 PRT Artificial Sequence Core polypeptide 527Phe Leu Leu Thr Arg Ile Leu Thr Ile Pro Gln Ser Leu Asp Ser Trp 1 5 10 15Trp Thr Ser Leu Asn Phe Leu Gly Gly Thr Thr Val Cys Leu Gly Gln 20 25 30Asn Ser Gln 35 528 35 PRT Artificial Sequence Core polypeptide 528Leu Leu Thr Arg Ile Leu Thr Ile Pro Gln Ser Leu Asp Ser Trp Trp 1 5 10 15Thr Ser Leu Asn Phe Leu Gly Gly Thr Thr Val Cys Leu Gly Gln Asn 20 25 30Ser Gln Ser 35 529 35 PRT Artificial Sequence Core polypeptide 529Leu Thr Arg Ile Leu Thr Ile Pro Gln Ser Leu Asp Ser Trp Trp Thr 1 5 10 15Ser Leu Asn Phe Leu Gly Gly Thr Thr Val Cys Leu Gly Gln Asn Ser 20 25 30Gln Ser Pro 35 530 13 PRT Artificial Sequence Core polypeptide 530Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Ala 1 5 10 531 13 PRT Artificial Sequence Core polypeptide 531Leu Glu Leu Asp Lys Trp Ala Ser Ala Trp Asn Trp Phe 1 5 10 532 13 PRT Artificial Sequence Core polypeptide 532Leu Glu Leu Asp Lys Ala Ala Ser Leu Trp Asn Trp Phe 1 5 10 533 13 PRT Artificial Sequence Core polypeptide 533Leu Lys Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe 1 5 10 534 13 PRT Artificial Sequence Core polypeptide 534Leu Glu Leu Lys Lys Trp Ala Ser Leu Trp Asn Trp Phe 1 5 10 535 13 PRT Artificial Sequence Core polypeptide 535Asp Glu Leu Leu His Asn Val Asn Ala Gly Lys Ser Thr 1 5 10 536 15 PRT Artificial Sequence Core polypeptide 536Lys Ser Asp Glu Leu Leu His Asn Val Asn Ala Gly Lys Ser Thr 1 5 10 15 537 17 PRT Artificial Sequence Core polypeptide 537Ile Arg Lys Ser Asp Glu Leu Leu His Asn Val Asn Ala Gly Lys Ser 1 5 10 15Thr 538 19 PRT Artificial Sequence Core polypeptide 538Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu His Asn Val Asn Ala Gly 1 5 10 15Lys Ser Thr 539 19 PRT Artificial Sequence Core polypeptide 539Phe Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser Leu 1 5 10 15Ala Phe Ile 540 36 PRT Artificial Sequence Core polypeptide 540Tyr Ala Ala Asp Lys Glu Ser Thr Gln Lys Ala Phe Asp Gly Ile Thr 1 5 10 15Asn Lys Val Asn Ser Val Ile Glu Lys Met Asn Thr Gln Phe Glu Ala 20 25 30Val Gly Lys Glu 35 541 36 PRT Artificial Sequence Core polypeptide 541Ser Val Ile Glu Lys Met Asn Thr Gln Phe Glu Ala Val Gly Lys Glu 1 5 10 15Phe Gly Asn Leu Glu Arg Arg Leu Glu Asn Leu Asn Lys Arg Met Glu 20 25 30Asp Gly Phe Leu 35 542 36 PRT Artificial Sequence Core polypeptide 542Val Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Met Glu Asn Glu Arg 1 5 10 15Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Asp Lys Val 20 25 30Arg Met Gln Leu 35 543 33 PRT Artificial Sequence Core polypeptide 543Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser Leu Ile His Ser Leu 1 5 10 15Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Gly Gly 20 25 30Cys 544 35 PRT Artificial Sequence Core polypeptide 544Ile Asn Asn Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln 1 5 10 15Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp 20 25 30Ala Ser Leu 35 545 28 PRT Artificial Sequence Core polypeptide 545Ile Asn Asn Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln 1 5 10 15Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu 20 25 546 35 PRT Artificial Sequence Core polypeptide 546Trp Met Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser Leu Ile His 1 5 10 15Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu 20 25 30Leu Leu Glu 35 547 48 PRT Artificial Sequence Core polypeptide 547Met Thr Trp Met Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser Leu 1 5 10 15Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu 20 25 30Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe 35 40 45 548 35 PRT Artificial Sequence Core polypeptide 548Ile Asp Ile Ser Ile Glu Leu Asn Lys Ala Lys Ser Asp Leu Glu Glu 1 5 10 15Ser Lys Glu Trp Ile Lys Lys Ser Asn Gln Lys Leu Asp Ser Ile Gly 20 25 30Asn Trp His 35 549 36 PRT Artificial Sequence Core polypeptide 549Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp 1 5 10 15Ala Ser Leu Trp Asn Trp Phe Asn Ile Thr Asn Trp Leu Trp Tyr Ile 20 25 30Lys Ile Phe Ile 35 550 36 PRT Artificial Sequence Core polypeptide 550Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys 1 5 10 15Trp Ala Ser Leu Trp Asn Trp Phe Asn Ile Thr Asn Trp Leu Trp Tyr 20 25 30Ile Lys Ile Phe 35 551 36 PRT Artificial Sequence Core polypeptide 551Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp 1 5 10 15Lys Trp Ala Ser Leu Trp Asn Trp Phe Asn Ile Thr Asn Trp Leu Trp 20 25 30Tyr Ile Lys Ile 35 552 36 PRT Artificial Sequence Core polypeptide 552Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu 1 5 10 15Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe Asn Ile Thr Asn Trp Leu 20 25 30Trp Tyr Ile Lys 35 553 36 PRT Artificial Sequence Core polypeptide 553Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu 1 5 10 15Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe Asn Ile Thr Asn Trp 20 25 30Leu Trp Tyr Ile 35 554 36 PRT Artificial Sequence Core polypeptide 554Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu 1 5 10 15Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe Asn Ile Thr Asn 20 25 30Trp Leu Trp Tyr 35 555 36 PRT Artificial Sequence Core polypeptide 555Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu 1 5 10 15Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe Asn Ile Thr 20 25 30Asn Trp Leu Trp 35 556 36 PRT Artificial Sequence Core polypeptide 556Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu 1 5 10 15Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe Asn Ile 20 25 30Thr Asn Trp Leu 35 557 36 PRT Artificial Sequence Core polypeptide 557His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln 1 5 10 15Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe Asn 20 25 30Ile Thr Asn Trp 35 558 36 PRT Artificial Sequence Core polypeptide 558Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu 1 5 10 15Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe 20 25 30Asn Ile Thr Asn 35 559 36 PRT Artificial Sequence Core polypeptide 559Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn 1 5 10 15Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp 20 25 30Phe Asn Ile Thr 35 560 36 PRT Artificial Sequence Core polypeptide 560Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys 1 5 10 15Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn 20 25 30Trp Phe Asn Ile 35 561 36 PRT Artificial Sequence Core polypeptide 561Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu 1 5 10 15Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp 20 25 30Asn Trp Phe Asn 35 562 36 PRT Artificial Sequence Core polypeptide 562Asn Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln 1 5 10 15Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser 20 25 30Leu Trp Asn Trp 35 563 36 PRT Artificial Sequence Core polypeptide 563Asn Asn Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn 1 5 10 15Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala 20 25 30Ser Leu Trp Asn 35 564 36 PRT Artificial Sequence Core polypeptide 564Ile Asn Asn Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln 1 5 10 15Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp 20 25 30Ala Ser Leu Trp 35 565 36 PRT Artificial Sequence Core polypeptide 565Glu Ile Asn Asn Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser 1 5 10 15Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys 20 25 30Trp Ala Ser Leu 35 566 36 PRT Artificial Sequence Core polypeptide 566Arg Glu Ile Asn Asn Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu 1 5 10 15Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp 20 25 30Lys Trp Ala Ser 35 567 36 PRT Artificial Sequence Core polypeptide 567Asp Arg Glu Ile Asn Asn Tyr Thr Ser Leu Ile His Ser Leu Ile Glu 1 5 10 15Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu 20 25 30Asp Lys Trp Ala 35 568 36 PRT Artificial Sequence Core polypeptide 568Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser Leu Ile His Ser Leu Ile 1 5 10 15Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu 20 25 30Leu Asp Lys Trp 35 569 36 PRT Artificial Sequence Core polypeptide 569Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser Leu Ile His Ser Leu 1 5 10 15Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu 20 25 30Glu Leu Asp Lys 35 570 38 PRT Artificial Sequence Core polypeptide 570Met Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser Leu Ile His Ser 1 5 10 15Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu 20 25 30Leu Glu Leu Asp Asn His 35 571 36 PRT Artificial Sequence Core polypeptide 571Met Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser Leu Ile His Ser 1 5 10 15Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu 20 25 30Leu Glu Leu Asp 35 572 36 PRT Artificial Sequence Core polypeptide 572Trp Met Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser Leu Ile His 1 5 10 15Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu 20 25 30Leu Leu Glu Leu 35 573 36 PRT Artificial Sequence Core polypeptide 573Thr Trp Met Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser Leu Ile 1 5 10 15His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln 20 25 30Glu Leu Leu Glu 35 574 36 PRT Artificial Sequence Core polypeptide 574Met Thr Trp Met Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser Leu 1 5 10 15Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu 20 25 30Gln Glu Leu Leu 35 575 36 PRT Artificial Sequence Core polypeptide 575Asn Met Thr Trp Met Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser 1 5 10 15Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn 20 25 30Glu Gln Glu Leu 35 576 36 PRT Artificial Sequence Core polypeptide 576Asn Asn Met Thr Trp Met Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr 1 5 10 15Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys 20 25 30Asn Glu Gln Glu 35 577 36 PRT Artificial Sequence Core polypeptide 577Trp Asn Asn Met Thr Trp Met Glu Trp Asp Arg Glu Ile Asn Asn Tyr 1 5 10 15Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu 20 25 30Lys Asn Glu Gln 35 578 36 PRT Artificial Sequence Core polypeptide 578Ile Trp Asn Asn Met Thr Trp Met Glu Trp Asp Arg Glu Ile Asn Asn 1 5 10 15Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 20 25 30Glu Lys Asn Glu 35 579 36 PRT Artificial Sequence Core polypeptide 579Gln Ile Trp Asn Asn Met Thr Trp Met Glu Trp Asp Arg Glu Ile Asn 1 5 10 15Asn Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln 20 25 30Gln Glu Lys Asn 35 580 36 PRT Artificial Sequence Core polypeptide 580Glu Gln Ile Trp Asn Asn Met Thr Trp Met Glu Trp Asp Arg Glu Ile 1 5 10 15Asn Asn Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn 20 25 30Gln Gln Glu Lys 35 581 36 PRT Artificial Sequence Core polypeptide 581Leu Glu Gln Ile Trp Asn Asn Met Thr Trp Met Glu Trp Asp Arg Glu 1 5 10 15Ile Asn Asn Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln 20 25 30Asn Gln Gln Glu 35 582 36 PRT Artificial Sequence Core polypeptide 582Ser Leu Glu Gln Ile Trp Asn Asn Met Thr Trp Met Glu Trp Asp Arg 1 5 10 15Glu Ile Asn Asn Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser 20 25 30Gln Asn Gln Gln 35 583 36 PRT Artificial Sequence Core polypeptide 583Lys Ser Leu Glu Gln Ile Trp Asn Asn Met Thr Trp Met Glu Trp Asp 1 5 10 15Arg Glu Ile Asn Asn Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu 20 25 30Ser Gln Asn Gln 35 584 36 PRT Artificial Sequence Core polypeptide 584Asn Lys Ser Leu Glu Gln Ile Trp Asn Asn Met Thr Trp Met Glu Trp 1 5 10 15Asp Arg Glu Ile Asn Asn Tyr Thr Ser Leu Ile His Ser Leu Ile Glu 20 25 30Glu Ser Gln Asn 35 585 21 PRT Artificial Sequence Core polypeptide 585Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu His Asn Val Asn 1 5 10 15Ala Gly Lys Ser Thr 20 586 21 PRT Artificial Sequence Core polypeptide 586Phe Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser Leu 1 5 10 15Ala Phe Ile Arg Lys 20 587 36 PRT Artificial Sequence Core polypeptide 587Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Gln Gln Gln 1 5 10 15Glu Lys Gln Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Asn Trp Phe 35 588 33 PRT Artificial Sequence Core polypeptide 588Phe Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser Leu 1 5 10 15Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu His Asn Val Asn Ala Gly 20 25 30Lys 589 31 PRT Artificial Sequence Core polypeptide 589Phe Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser Leu 1 5 10 15Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu His Asn Val Asn Ala 20 25 30 590 29 PRT Artificial Sequence Core polypeptide 590Phe Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser Leu 1 5 10 15Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu His Asn Val 20 25 591 27 PRT Artificial Sequence Core polypeptide 591Phe Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser Leu 1 5 10 15Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu His 20 25 592 25 PRT Artificial Sequence Core polypeptide 592Phe Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser Leu 1 5 10 15Ala Phe Ile Arg Lys Ser Asp Glu Leu 20 25 593 23 PRT Artificial Sequence Core polypeptide 593Phe Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser Leu 1 5 10 15Ala Phe Ile Arg Lys Ser Asp 20 594 33 PRT Artificial Sequence Core polypeptide 594Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser Leu Ala Phe 1 5 10 15Ile Arg Lys Ser Asp Glu Leu Leu His Asn Val Asn Ala Gly Lys Ser 20 25 30Thr 595 31 PRT Artificial Sequence Core polypeptide 595Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg 1 5 10 15Lys Ser Asp Glu Leu Leu His Asn Val Asn Ala Gly Lys Ser Thr 20 25 30 596 29 PRT Artificial Sequence Core polypeptide 596Gln Val Asn Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser 1 5 10 15Asp Glu Leu Leu His Asn Val Asn Ala Gly Lys Ser Thr 20 25 597 27 PRT Artificial Sequence Core polypeptide 597Asn Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu 1 5 10 15Leu Leu His Asn Val Asn Ala Gly Lys Ser Thr 20 25 598 25 PRT Artificial Sequence Core polypeptide 598Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu 1 5 10 15His Asn Val Asn Ala Gly Lys Ser Thr 20 25 599 23 PRT Artificial Sequence Core polypeptide 599Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu His Asn 1 5 10 15Val Asn Ala Gly Lys Ser Thr 20 600 30 PRT Artificial Sequence Core polypeptide 600Phe Trp Asn Trp Leu Ser Ala Trp Lys Asp Leu Glu Leu Tyr Pro Gly 1 5 10 15Ser Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe 20 25 30 601 41 PRT Artificial Sequence Core polypeptide 601Cys Gly Gly Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu 1 5 10 15Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Ile Leu 20 25 30Ala Val Glu Arg Tyr Leu Lys Asp Gln 35 40 602 39 PRT Artificial Sequence Core polypeptide 602Cys Gly Gly Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln 1 5 10 15Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp 20 25 30Ala Ser Leu Trp Asn Trp Phe 35 603 36 PRT Artificial Sequence Core polypeptide 603Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Asn Trp Phe 35 604 38 PRT Artificial Sequence Core polypeptide 604Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu 1 5 10 15Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala Val Glu 20 25 30Arg Tyr Leu Lys Asp Gln 35 605 36 PRT Artificial Sequence Core polypeptide 605Glu Lys Asn Met Tyr Glu Leu Gln Lys Leu Asn Ser Trp Asp Val Phe 1 5 10 15Thr Asn Trp Leu Asp Phe Thr Ser Trp Val Arg Tyr Ile Gln Tyr Ile 20 25 30Gln Tyr Gly Val 35 606 36 PRT Artificial Sequence Core polypeptide 606Gln Glu Lys Asn Met Tyr Glu Leu Gln Lys Leu Asn Ser Trp Asp Val 1 5 10 15Phe Thr Asn Trp Leu Asp Phe Thr Ser Trp Val Arg Tyr Ile Gln Tyr 20 25 30Ile Gln Tyr Gly 35 607 36 PRT Artificial Sequence Core polypeptide 607Gln Gln Glu Lys Asn Met Tyr Glu Leu Gln Lys Leu Asn Ser Trp Asp 1 5 10 15Val Phe Thr Asn Trp Leu Asp Phe Thr Ser Trp Val Arg Tyr Ile Gln 20 25 30Tyr Ile Gln Tyr 35 608 36 PRT Artificial Sequence Core polypeptide 608Ile Gln Gln Glu Lys Asn Met Tyr Glu Leu Gln Lys Leu Asn Ser Trp 1 5 10 15Asp Val Phe Thr Asn Trp Leu Asp Phe Thr Ser Trp Val Arg Tyr Ile 20 25 30Gln Tyr Ile Gln 35 609 36 PRT Artificial Sequence Core polypeptide 609Gln Ile Gln Gln Glu Lys Asn Met Tyr Glu Leu Gln Lys Leu Asn Ser 1 5 10 15Trp Asp Val Phe Thr Asn Trp Leu Asp Phe Thr Ser Trp Val Arg Tyr 20 25 30Ile Gln Tyr Ile 35 610 36 PRT Artificial Sequence Core polypeptide 610Ala Gln Ile Gln Gln Glu Lys Asn Met Tyr Glu Leu Gln Lys Leu Asn 1 5 10 15Ser Trp Asp Val Phe Thr Asn Trp Leu Asp Phe Thr Ser Trp Val Arg 20 25 30Tyr Ile Gln Tyr 35 611 36 PRT Artificial Sequence Core polypeptide 611Gln Ala Gln Ile Gln Gln Glu Lys Asn Met Tyr Glu Leu Gln Lys Leu 1 5 10 15Asn Ser Trp Asp Val Phe Thr Asn Trp Leu Asp Phe Thr Ser Trp Val 20 25 30Arg Tyr Ile Gln 35 612 36 PRT Artificial Sequence Core polypeptide 612Glu Gln Ala Gln Ile Gln Gln Glu Lys Asn Met Tyr Glu Leu Gln Lys 1 5 10 15Leu Asn Ser Trp Asp Val Phe Thr Asn Trp Leu Asp Phe Thr Ser Trp 20 25 30Val Arg Tyr Ile 35 613 36 PRT Artificial Sequence Core polypeptide 613Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Asn Met Tyr Glu Leu Gln 1 5 10 15Lys Leu Asn Ser Trp Asp Val Phe Thr Asn Trp Leu Asp Phe Thr Ser 20 25 30Trp Val Arg Tyr 35 614 36 PRT Artificial Sequence Core polypeptide 614Ser Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Asn Met Tyr Glu Leu 1 5 10 15Gln Lys Leu Asn Ser Trp Asp Val Phe Thr Asn Trp Leu Asp Phe Thr 20 25 30Ser Trp Val Arg 35 615 36 PRT Artificial Sequence Core polypeptide 615Gln Ser Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Asn Met Tyr Glu 1 5 10 15Leu Gln Lys Leu Asn Ser Trp Asp Val Phe Thr Asn Trp Leu Asp Phe 20 25 30Thr Ser Trp Val 35 616 36 PRT Artificial Sequence Core polypeptide 616Ser Gln Ser Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Asn Met Tyr 1 5 10 15Glu Leu Gln Lys Leu Asn Ser Trp Asp Val Phe Thr Asn Trp Leu Asp 20 25 30Phe Thr Ser Trp 35 617 36 PRT Artificial Sequence Core polypeptide 617Ile Ser Gln Ser Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Asn Met 1 5 10 15Tyr Glu Leu Gln Lys Leu Asn Ser Trp Asp Val Phe Thr Asn Trp Leu 20 25 30Asp Phe Thr Ser 35 618 36 PRT Artificial Sequence Core polypeptide 618Asn Ile Ser Gln Ser Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Asn 1 5 10 15Met Tyr Glu Leu Gln Lys Leu Asn Ser Trp Asp Val Phe Thr Asn Trp 20 25 30Leu Asp Phe Thr 35 619 36 PRT Artificial Sequence Core polypeptide 619Ala Asn Ile Ser Gln Ser Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys 1 5 10 15Asn Met Tyr Glu Leu Gln Lys Leu Asn Ser Trp Asp Val Phe Thr Asn 20 25 30Trp Leu Asp Phe 35 620 36 PRT Artificial Sequence Core polypeptide 620Glu Ala Asn Ile Ser Gln Ser Leu Glu Gln Ala Gln Ile Gln Gln Glu 1 5 10 15Lys Asn Met Tyr Glu Leu Gln Lys Leu Asn Ser Trp Asp Val Phe Thr 20 25 30Asn Trp Leu Asp 35 621 36 PRT Artificial Sequence Core polypeptide 621Leu Glu Ala Asn Ile Ser Gln Ser Leu Glu Gln Ala Gln Ile Gln Gln 1 5 10 15Glu Lys Asn Met Tyr Glu Leu Gln Lys Leu Asn Ser Trp Asp Val Phe 20 25 30Thr Asn Trp Leu 35 622 36 PRT Artificial Sequence Core polypeptide 622Tyr Leu Glu Ala Asn Ile Ser Gln Ser Leu Glu Gln Ala Gln Ile Gln 1 5 10 15Gln Glu Lys Asn Met Tyr Glu Leu Gln Lys Leu Asn Ser Trp Asp Val 20 25 30Phe Thr Asn Trp 35 623 23 PRT Artificial Sequence Core polypeptide 623Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu 20 624 36 PRT Artificial Sequence Core polypeptide 624Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Leu Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Asn Trp Phe 35 625 36 PRT Artificial Sequence Core polypeptide 625Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Leu Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Asn Trp Phe 35 626 36 PRT Artificial Sequence Core polypeptide 626Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Phe Asp Lys Trp Ala Ser Leu 20 25 30Trp Asn Trp Phe 35 627 36 PRT Artificial Sequence Core polypeptide 627Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Pro Ala Ser Leu 20 25 30Trp Asn Trp Phe 35 628 36 PRT Artificial Sequence Core polypeptide 628Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Pro 20 25 30Trp Asn Trp Phe 35 629 36 PRT Artificial Sequence Core polypeptide 629Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Asn Ser Phe 35 630 36 PRT Artificial Sequence Core polypeptide 630Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Asn Trp Phe 35 631 36 PRT Artificial Sequence Core polypeptide 631Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Asn Trp Phe 35 632 39 PRT Artificial Sequence Core polypeptide 632Phe Met Cys Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln 1 5 10 15Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp 20 25 30Ala Ser Leu Trp Asn Trp Phe 35 633 41 PRT Artificial Sequence Core polypeptide 633Phe Met Cys Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu 1 5 10 15Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Ile Leu 20 25 30Ala Val Glu Arg Tyr Leu Lys Asp Gln 35 40 634 30 PRT Artificial Sequence Core polypeptide 634Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser Leu Ile His Ser Leu 1 5 10 15Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu 20 25 30 635 29 PRT Artificial Sequence Core polypeptide 635Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu 1 5 10 15Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe 20 25 636 35 PRT Artificial Sequence Core polypeptide 636Phe Trp Asn Trp Leu Ser Ala Trp Lys Asp Leu Glu Leu Gly Gly Pro 1 5 10 15Gly Ser Gly Pro Gly Gly Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp 20 25 30Asn Trp Phe 35 637 29 PRT Artificial Sequence Core polypeptide 637Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn 1 5 10 15Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 638 35 PRT Artificial Sequence Core polypeptide 638Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu 1 5 10 15Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp 20 25 30Asn Trp Phe 35 639 33 PRT Artificial Sequence Core polypeptide 639Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn 1 5 10 15Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp 20 25 30Phe 640 41 PRT Artificial Sequence Core polypeptide 640Gly Gly Gly Gly Gly Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu 1 5 10 15Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp 20 25 30Lys Trp Ala Ser Leu Trp Asn Trp Phe 35 40 641 31 PRT Artificial Sequence Core polypeptide 641His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln 1 5 10 15Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe 20 25 30 642 36 PRT Artificial Sequence Core polypeptide 642Tyr Thr Ser Leu Ile Tyr Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Asn Trp Phe 35 643 36 PRT Artificial Sequence Core polypeptide 643Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Lys Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Asn Trp Phe 35 644 36 PRT Artificial Sequence Core polypeptide 644Tyr Thr Ser Leu Ile His Ser Ser Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Asn Trp Phe 35 645 36 PRT Artificial Sequence Core polypeptide 645Leu Glu Ala Asn Ile Ser Gln Leu Leu Glu Gln Ala Gln Ile Gln Gln 1 5 10 15Glu Lys Asn Met Tyr Glu Leu Gln Lys Leu Asn Ser Trp Asp Val Phe 20 25 30Thr Asn Trp Leu 35 646 35 PRT Artificial Sequence Core polypeptide 646Ser Leu Glu Glu Cys Asp Ser Glu Leu Glu Ile Lys Arg Tyr Lys Asn 1 5 10 15Arg Val Ala Ser Arg Lys Cys Arg Ala Lys Phe Lys Gln Leu Leu Gln 20 25 30His Tyr Arg 35 647 35 PRT Artificial Sequence Core polypeptide 647Leu Glu Glu Cys Asp Ser Glu Leu Glu Ile Lys Arg Tyr Lys Asn Arg 1 5 10 15Val Ala Ser Arg Lys Cys Arg Ala Lys Phe Lys Gln Leu Leu Gln His 20 25 30Tyr Arg Glu 35 648 35 PRT Artificial Sequence Core polypeptide 648Glu Glu Cys Asp Ser Glu Leu Glu Ile Lys Arg Tyr Lys Asn Arg Val 1 5 10 15Ala Ser Arg Lys Cys Arg Ala Lys Phe Lys Gln Leu Leu Gln His Tyr 20 25 30Arg Glu Val 35 649 35 PRT Artificial Sequence Core polypeptide 649Glu Cys Asp Ser Glu Leu Glu Ile Lys Arg Tyr Lys Asn Arg Val Ala 1 5 10 15Ser Arg Lys Cys Arg Ala Lys Phe Lys Gln Leu Leu Gln His Tyr Arg 20 25 30Glu Val Ala 35 650 35 PRT Artificial Sequence Core polypeptide 650Cys Asp Ser Glu Leu Glu Ile Lys Arg Tyr Lys Asn Arg Val Ala Ser 1 5 10 15Arg Lys Cys Arg Ala Lys Phe Lys Gln Leu Leu Gln His Tyr Arg Glu 20 25 30Val Ala Ala 35 651 35 PRT Artificial Sequence Core polypeptide 651Asp Ser Glu Leu Glu Ile Lys Arg Tyr Lys Asn Arg Val Ala Ser Arg 1 5 10 15Lys Cys Arg Ala Lys Phe Lys Gln Leu Leu Gln His Tyr Arg Glu Val 20 25 30Ala Ala Ala 35 652 49 PRT Artificial Sequence Core polypeptide 652Asp Glu Ser Ala Met Ile Asn Thr Tyr Arg Ser Ile Asn Glu Phe Asp 1 5 10 15Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser Leu Ala Phe 20 25 30Ile Arg Lys Ser Asp Glu Leu Leu His Asn Val Asn Ala Gly Lys Ser 35 40 45Thr 653 7 PRT Artificial Sequence Core polypeptide 653Trp Ala Ser Leu Trp Asn Trp 1 5 654 38 PRT Artificial Sequence Core polypeptide 654Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln 1 5 10 15Leu Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr Leu Lys Asp Gln Gln 20 25 30Leu Leu Gly Ile Trp Gly 35 655 38 PRT Artificial Sequence Core polypeptide 655Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly Ile Lys 1 5 10 15Gln Leu Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr Leu Lys Asp Gln 20 25 30Gln Leu Leu Gly Ile Trp 35 656 38 PRT Artificial Sequence Core polypeptide 656Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly Ile 1 5 10 15Lys Gln Leu Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr Leu Lys Asp 20 25 30Gln Gln Leu Leu Gly Ile 35 657 38 PRT Artificial Sequence Core polypeptide 657Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly 1 5 10 15Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr Leu Lys 20 25 30Asp Gln Gln Leu Leu Gly 35 658 38 PRT Artificial Sequence Core polypeptide 658Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp 1 5 10 15Gly Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr Leu 20 25 30Lys Asp Gln Gln Leu Leu 35 659 38 PRT Artificial Sequence Core polypeptide 659Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val 1 5 10 15Trp Gly Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr 20 25 30Leu Lys Asp Gln Gln Leu 35 660 38 PRT Artificial Sequence Core polypeptide 660Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr 1 5 10 15Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala Val Glu Arg 20 25 30Tyr Leu Lys Asp Gln Gln 35 661 38 PRT Artificial Sequence Core polypeptide 661Gln Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln 1 5 10 15Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala Val 20 25 30Glu Arg Tyr Leu Lys Asp 35 662 38 PRT Artificial Sequence Core polypeptide 662Gln Gln Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu 1 5 10 15Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala 20 25 30Val Glu Arg Tyr Leu Lys 35 663 38 PRT Artificial Sequence Core polypeptide 663Gln Gln Gln Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu 1 5 10 15Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Ile Leu 20 25 30Ala Val Glu Arg Tyr Leu 35 664 38 PRT Artificial Sequence Core polypeptide 664Val Gln Gln Gln Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His 1 5 10 15Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Ile 20 25 30Leu Ala Val Glu Arg Tyr 35 665 38 PRT Artificial Sequence Core polypeptide 665Ile Val Gln Gln Gln Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln 1 5 10 15His Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg 20 25 30Ile Leu Ala Val Glu Arg 35 666 38 PRT Artificial Sequence Core polypeptide 666Gly Ile Val Gln Gln Gln Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln 1 5 10 15Gln His Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala 20 25 30Arg Ile Leu Ala Val Glu 35 667 38 PRT Artificial Sequence Core polypeptide 667Ser Gly Ile Val Gln Gln Gln Asn Asn Leu Leu Arg Ala Ile Glu Ala 1 5 10 15Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln 20 25 30Ala Arg Ile Leu Ala Val 35 668 38 PRT Artificial Sequence Core polypeptide 668Arg Ser Met Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile 1 5 10 15Val Gln Gln Gln Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His 20 25 30Leu Leu Gln Leu Thr Val 35 669 38 PRT Artificial Sequence Core polypeptide 669Gly Ala Arg Ser Met Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser 1 5 10 15Gly Ile Val Gln Gln Gln Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln 20 25 30Gln His Leu Leu Gln Leu 35 670 38 PRT Artificial Sequence Core polypeptide 670Gly Ser Thr Met Gly Ala Arg Ser Met Thr Leu Thr Val Gln Ala Arg 1 5 10 15Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu Leu Arg Ala 20 25 30Ile Glu Ala Gln Gln His 35 671 38 PRT Artificial Sequence Core polypeptide 671Gly Ser Thr Met Gly Ala Arg Ser Met Thr Leu Thr Val Gln Ala Arg 1 5 10 15Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu Leu Arg Ala 20 25 30Ile Glu Ala Gln Gln His 35 672 38 PRT Artificial Sequence Core polypeptide 672Glu Gly Ser Thr Met Gly Ala Arg Ser Met Thr Leu Thr Val Gln Ala 1 5 10 15Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu Leu Arg 20 25 30Ala Ile Glu Ala Gln Gln 35 673 28 PRT Artificial Sequence Core polypeptide 673Arg Ala Lys Phe Lys Gln Leu Leu Gln His Tyr Arg Glu Val Ala Ala 1 5 10 15Ala Lys Ser Ser Glu Asn Asp Arg Leu Arg Leu Leu 20 25 674 28 PRT Artificial Sequence Core polypeptide 674Ala Lys Phe Lys Gln Leu Leu Gln His Tyr Arg Glu Val Ala Ala Ala 1 5 10 15Lys Ser Ser Glu Asn Asp Arg Leu Arg Leu Leu Leu 20 25 675 28 PRT Artificial Sequence Core polypeptide 675Lys Phe Lys Gln Leu Leu Gln His Tyr Arg Glu Val Ala Ala Ala Lys 1 5 10 15Ser Ser Glu Asn Asp Arg Leu Arg Leu Leu Leu Lys 20 25 676 28 PRT Artificial Sequence Core polypeptide 676Phe Lys Gln Leu Leu Gln His Tyr Arg Glu Val Ala Ala Ala Lys Ser 1 5 10 15Ser Glu Asn Asp Arg Leu Arg Leu Leu Leu Lys Gln 20 25 677 35 PRT Artificial Sequence Core polypeptide 677Arg Ala Lys Phe Lys Gln Glu Leu Gln His Tyr Arg Glu Val Ala Ala 1 5 10 15Ala Lys Ser Ser Glu Asn Asp Arg Leu Arg Leu Leu Leu Lys Gln Met 20 25 30Cys Pro Ser 35 678 10 PRT Artificial Sequence Core polypeptide 678Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe 1 5 10 679 35 PRT Artificial Sequence Core polypeptide 679Phe Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser Leu 1 5 10 15Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu His Asn Val Asn Ala Gly 20 25 30Lys Ser Thr 35 680 35 PRT Artificial Sequence Core polypeptide 680Tyr Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser Leu 1 5 10 15Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu His Asn Val Asn Ala Gly 20 25 30Lys Ser Thr 35 681 35 PRT Artificial Sequence Core polypeptide 681Tyr Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser Leu 1 5 10 15Ala Tyr Ile Arg Lys Ser Asp Glu Leu Leu His Asn Val Asn Ala Gly 20 25 30Lys Ser Thr 35 682 35 PRT Artificial Sequence Core polypeptide 682Phe Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser Leu 1 5 10 15Ala Tyr Ile Arg Lys Ser Asp Glu Leu Leu His Asn Val Asn Ala Gly 20 25 30Lys Ser Thr 35 683 35 PRT Artificial Sequence Core polypeptide 683Phe Asp Ala Ser Ile Ser Gln Val Gln Glu Lys Ile Gln Gln Ser Leu 1 5 10 15Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu His Gln Val Gln Ala Gly 20 25 30Lys Ser Thr 35 684 35 PRT Artificial Sequence Core polypeptide 684Phe Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ala Leu 1 5 10 15Ala Phe Ile Arg Lys Ala Asp Glu Leu Leu His Asn Val Asn Ala Gly 20 25 30Lys Ser Thr 35 685 35 PRT Artificial Sequence Core polypeptide 685Phe Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ala Leu 1 5 10 15Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu His Asn Val Asn Ala Gly 20 25 30Lys Ser Thr 35 686 35 PRT Artificial Sequence Core polypeptide 686Phe Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser Leu 1 5 10 15Ala Phe Ile Arg Lys Ala Asp Glu Leu Leu His Asn Val Asn Ala Gly 20 25 30Lys Ser Thr 35 687 35 PRT Artificial Sequence Core polypeptide 687Tyr Asp Ala Ser Ile Ser Gln Val Gln Glu Glu Ile Gln Gln Ala Leu 1 5 10 15Ala Phe Ile Arg Lys Ala Asp Glu Leu Leu Glu Gln Val Gln Ala Gly 20 25 30Lys Ser Thr 35 688 35 PRT Artificial Sequence Core polypeptide 688Phe Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser Leu 1 5 10 15Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu Glu Asn Val Asn Ala Gly 20 25 30Lys Ser Thr 35 689 35 PRT Artificial Sequence Core polypeptide 689Phe Asp Ala Ser Ile Ser Gln Val Asn Glu Glu Ile Asn Gln Ser Leu 1 5 10 15Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu His Asn Val Asn Ala Gly 20 25 30Lys Ser Thr 35 690 35 PRT Artificial Sequence Core polypeptide 690Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn Glu 1 5 10 15Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu 20 25 30Glu Asn Val 35 691 35 PRT Artificial Sequence Core polypeptide 691Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn Glu 1 5 10 15Glu Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu 20 25 30Glu Asn Val 35 692 35 PRT Artificial Sequence Core polypeptide 692Val Tyr Pro Ser Asp Glu Tyr Asp Ala Ser Ile Ser Gln Val Asn Glu 1 5 10 15Glu Ile Asn Gln Ala Leu Ala Tyr Ile Arg Lys Ala Asp Glu Leu Leu 20 25 30Glu Asn Val 35 693 35 PRT Artificial Sequence Core polypeptide 693Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn Glu 1 5 10 15Glu Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu 20 25 30His Asn Val 35 694 36 PRT Artificial Sequence Core polypeptide 694Ser Asn Lys Ser Leu Glu Gln Ile Trp Asn Asn Met Thr Trp Met Glu 1 5 10 15Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser Leu Ile His Ser Leu Ile 20 25 30Glu Glu Ser Gln 35 695 36 PRT Artificial Sequence Core polypeptide 695Trp Ser Asn Lys Ser Leu Glu Gln Ile Trp Asn Asn Met Thr Trp Met 1 5 10 15Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser Leu Ile His Ser Leu 20 25 30Ile Glu Glu Ser 35 696 36 PRT Artificial Sequence Core polypeptide 696Ser Trp Ser Asn Lys Ser Leu Glu Gln Ile Trp Asn Asn Met Thr Trp 1 5 10 15Met Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser Leu Ile His Ser 20 25 30Leu Ile Glu Glu 35 697 36 PRT Artificial Sequence Core polypeptide 697Ala Ser Trp Ser Asn Lys Ser Leu Glu Gln Ile Trp Asn Asn Met Thr 1 5 10 15Trp Met Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser Leu Ile His 20 25 30Ser Leu Ile Glu 35 698 36 PRT Artificial Sequence Core polypeptide 698Asn Ala Ser Trp Ser Asn Lys Ser Leu Glu Gln Ile Trp Asn Asn Met 1 5 10 15Thr Trp Met Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser Leu Ile 20 25 30His Ser Leu Ile 35 699 36 PRT Artificial Sequence Core polypeptide 699Trp Asn Ala Ser Trp Ser Asn Lys Ser Leu Glu Gln Ile Trp Asn Asn 1 5 10 15Met Thr Trp Met Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser Leu 20 25 30Ile His Ser Leu 35 700 36 PRT Artificial Sequence Core polypeptide 700Pro Trp Asn Ala Ser Trp Ser Asn Lys Ser Leu Glu Gln Ile Trp Asn 1 5 10 15Asn Met Thr Trp Met Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser 20 25 30Leu Ile His Ser 35 701 36 PRT Artificial Sequence Core polypeptide 701Val Pro Trp Asn Ala Ser Trp Ser Asn Lys Ser Leu Glu Gln Ile Trp 1 5 10 15Asn Asn Met Thr Trp Met Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr 20 25 30Ser Leu Ile His 35 702 36 PRT Artificial Sequence Core polypeptide 702Ala Val Pro Trp Asn Ala Ser Trp Ser Asn Lys Ser Leu Glu Gln Ile 1 5 10 15Trp Asn Asn Met Thr Trp Met Glu Trp Asp Arg Glu Ile Asn Asn Tyr 20 25 30Thr Ser Leu Ile 35 703 36 PRT Artificial Sequence Core polypeptide 703Thr Ala Val Pro Trp Asn Ala Ser Trp Ser Asn Lys Ser Leu Glu Gln 1 5 10 15Ile Trp Asn Asn Met Thr Trp Met Glu Trp Asp Arg Glu Ile Asn Asn 20 25 30Tyr Thr Ser Leu 35 704 36 PRT Artificial Sequence Core polypeptide 704Thr Thr Ala Val Pro Trp Asn Ala Ser Trp Ser Asn Lys Ser Leu Glu 1 5 10 15Gln Ile Trp Asn Asn Met Thr Trp Met Glu Trp Asp Arg Glu Ile Asn 20 25 30Asn Tyr Thr Ser 35 705 36 PRT Artificial Sequence Core polypeptide 705Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Asn Trp Phe 35 706 35 PRT Artificial Sequence Core polypeptide 706Ala Ala Ala Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn Glu 1 5 10 15Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu 20 25 30His Asn Val 35 707 35 PRT Artificial Sequence Core polypeptide 707Val Phe Pro Ala Ala Ala Phe Asp Ala Ser Ile Ser Gln Val Asn Glu 1 5 10 15Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu 20 25 30His Asn Val 35 708 35 PRT Artificial Sequence Core polypeptide 708Val Phe Pro Ser Asp Glu Ala Ala Ala Ser Ile Ser Gln Val Asn Glu 1 5 10 15Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu 20 25 30His Asn Val 35 709 35 PRT Artificial Sequence Core polypeptide 709Val Phe Pro Ser Asp Glu Phe Asp Ala Ala Ala Ala Gln Val Asn Glu 1 5 10 15Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu 20 25 30His Asn Val 35 710 35 PRT Artificial Sequence Core polypeptide 710Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Ala Ala Ala Glu 1 5 10 15Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu 20 25 30His Asn Val 35 711 35 PRT Artificial Sequence Core polypeptide 711Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn Ala 1 5 10 15Ala Ala Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu 20 25 30His Asn Val 35 712 35 PRT Artificial Sequence Core polypeptide 712Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn Glu 1 5 10 15Lys Ile Ala Ala Ala Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu 20 25 30His Asn Val 35 713 35 PRT Artificial Sequence Core polypeptide 713Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn Glu 1 5 10 15Lys Ile Asn Gln Ser Ala Ala Ala Ile Arg Lys Ser Asp Glu Leu Leu 20 25 30His Asn Val 35 714 35 PRT Artificial Sequence Core polypeptide 714Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn Glu 1 5 10 15Lys Ile Asn Gln Ser Leu Ala Phe Ala Ala Ala Ser Asp Glu Leu Leu 20 25 30His Asn Val 35 715 35 PRT Artificial Sequence Core polypeptide 715Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn Glu 1 5 10 15Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ala Ala Ala Leu Leu 20 25 30His Asn Val 35 716 35 PRT Artificial Sequence Core polypeptide 716Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn Glu 1 5 10 15Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Ala Ala 20 25 30Ala Asn Val 35 717 35 PRT Artificial Sequence Core polypeptide 717Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn Glu 1 5 10 15Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu 20 25 30Ala Ala Ala 35 718 35 PRT Artificial Sequence Core polypeptide 718Val Tyr Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn Glu 1 5 10 15Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu 20 25 30His Asn Val 35 719 36 PRT Artificial Sequence Core polypeptide 719Ala Ala Ala Ala Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Asn Trp Phe 35 720 36 PRT Artificial Sequence Core polypeptide 720Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Gln Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Asn Trp Phe 35 721 36 PRT Artificial Sequence Core polypeptide 721Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Gln Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Asn Trp Phe 35 722 36 PRT Artificial Sequence Core polypeptide 722Gln Ile Trp Asn Asn Met Thr Trp Met Glu Trp Asp Arg Glu Ile Asn 1 5 10 15Asn Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln 20 25 30Gln Glu Lys Gln 35 723 36 PRT Artificial Sequence Core polypeptide 723Gln Ile Trp Asn Asn Met Thr Trp Met Glu Trp Asp Arg Glu Ile Asn 1 5 10 15Asn Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Gln Gln 20 25 30Gln Glu Lys Asn 35 724 36 PRT Artificial Sequence Core polypeptide 724Gln Ile Trp Asn Asn Met Thr Trp Met Glu Trp Asp Arg Glu Ile Asn 1 5 10 15Asn Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Gln Gln 20 25 30Gln Glu Lys Gln 35 725 36 PRT Artificial Sequence Core polypeptide 725Asn Lys Ser Leu Glu Gln Ile Trp Asn Asn Met Thr Trp Met Glu Trp 1 5 10 15Asp Arg Glu Ile Asn Asn Tyr Thr Ser Leu Ile His Ser Leu Ile Glu 20 25 30Glu Ser Gln Gln 35 726 35 PRT Artificial Sequence Core polypeptide 726Phe Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser Leu 1 5 10 15Ala Phe Ile Glu Glu Ser Asp Glu Leu Leu His Asn Val Asn Ala Gly 20 25 30Lys Ser Thr 35 727 9 PRT Artificial Sequence Core polypeptide 727Ile Arg Lys Ser Asp Glu Leu Cys Leu 1 5 728 36 PRT Artificial Sequence Core polypeptide 728Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asp Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Asn Trp Phe 35 729 36 PRT Artificial Sequence Core polypeptide 729Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asp Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Asn Trp Phe 35 730 36 PRT Artificial Sequence Core polypeptide 730Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asp Gln Gln 1 5 10 15Glu Lys Asp Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Asn Trp Phe 35 731 36 PRT Artificial Sequence Core polypeptide 731Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Asp Trp Phe 35 732 36 PRT Artificial Sequence Core polypeptide 732Leu Glu Ala Asn Ile Thr Gln Ser Leu Glu Gln Ala Gln Ile Gln Gln 1 5 10 15Glu Lys Asn Met Tyr Glu Leu Gln Lys Leu Asn Ser Trp Asp Val Phe 20 25 30Thr Asn Trp Leu 35 733 36 PRT Artificial Sequence Core polypeptide 733Leu Glu Ala Asn Ile Ser Ala Ser Leu Glu Gln Ala Gln Ile Gln Gln 1 5 10 15Glu Lys Asn Met Tyr Glu Leu Gln Lys Leu Asn Ser Trp Asp Val Phe 20 25 30Thr Asn Trp Leu 35 734 36 PRT Artificial Sequence Core polypeptide 734Leu Glu Ala Asn Ile Ser Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln 1 5 10 15Glu Lys Asn Met Tyr Glu Leu Gln Lys Leu Asn Ser Trp Asp Val Phe 20 25 30Thr Asn Trp Leu 35 735 36 PRT Artificial Sequence Core polypeptide 735Leu Glu Ala Asn Ile Thr Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln 1 5 10 15Glu Lys Asn Met Tyr Glu Leu Gln Lys Leu Asn Ser Trp Asp Val Phe 20 25 30Thr Asn Trp Leu 35 736 36 PRT Artificial Sequence Core polypeptide 736Leu Glu Ala Asn Ile Thr Ala Ser Leu Glu Gln Ala Gln Ile Gln Gln 1 5 10 15Glu Lys Asn Met Tyr Glu Leu Gln Lys Leu Asn Ser Trp Asp Val Phe 20 25 30Thr Asn Trp Leu 35 737 34 PRT Artificial Sequence Core polypeptide 737Arg Ala Lys Phe Lys Gln Leu Leu Gln His Tyr Arg Glu Val Ala Ala 1 5 10 15Ala Lys Ser Ser Glu Asn Asp Arg Leu Arg Leu Leu Leu Lys Gln Met 20 25 30Pro Ser 738 30 PRT Artificial Sequence Core polypeptide 738Met Asn Ser Val Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Glu Glu 1 5 10 15Glu Ser Lys Leu Asn Arg Asn Glu Ile Lys Gly Val Lys Leu 20 25 30 739 36 PRT Artificial Sequence Core polypeptide 739Trp Gln Glu Trp Glu Gln Lys Val Arg Tyr Leu Glu Ala Asn Ile Ser 1 5 10 15Gln Ser Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Asn Met Tyr Glu 20 25 30Leu Gln Lys Leu 35 740 35 PRT Artificial Sequence Core polypeptide 740Asp Glu Tyr Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln 1 5 10 15Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu His Asn Val Asn 20 25 30Ala Gly Lys 35 741 34 PRT Artificial Sequence Core polypeptide 741Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Asn 742 33 PRT Artificial Sequence Core polypeptide 742Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp 743 32 PRT Artificial Sequence Core polypeptide 743Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30 744 31 PRT Artificial Sequence Core polypeptide 744Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser 20 25 30 745 51 PRT Artificial Sequence Core polypeptide 745Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu 1 5 10 15Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp 20 25 30Gly Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr Leu 35 40 45Lys Asp Gln 50 746 42 PRT Artificial Sequence Core polypeptide 746Asp Arg Glu Ile Asn Asn Tyr Thr Ser Leu Ile His Ser Leu Ile Glu 1 5 10 15Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu 20 25 30Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe 35 40 747 42 PRT Artificial Sequence Core polypeptide 747Asn Asn Met Thr Trp Met Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr 1 5 10 15Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys 20 25 30Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys 35 40 748 36 PRT Artificial Sequence Core polypeptide 748Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Ala Ala Ala 35 749 36 PRT Artificial Sequence Core polypeptide 749Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ala Ala 20 25 30Ala Asn Trp Phe 35 750 36 PRT Artificial Sequence Core polypeptide 750Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Ala Ala Ala Ser Leu 20 25 30Trp Asn Trp Phe 35 751 36 PRT Artificial Sequence Core polypeptide 751Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Ala Ala Ala Lys Trp Ala Ser Leu 20 25 30Trp Asn Trp Phe 35 752 36 PRT Artificial Sequence Core polypeptide 752Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Ala Ala Ala Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Asn Trp Phe 35 753 36 PRT Artificial Sequence Core polypeptide 753Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Ala Ala Ala Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Asn Trp Phe 35 754 36 PRT Artificial Sequence Core polypeptide 754Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Ala 1 5 10 15Ala Ala Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Asn Trp Phe 35 755 36 PRT Artificial Sequence Core polypeptide 755Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Ala Ala Ala Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Asn Trp Phe 35 756 36 PRT Artificial Sequence Core polypeptide 756Tyr Thr Ser Leu Ile His Ser Leu Ile Ala Ala Ala Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Asn Trp Phe 35 757 36 PRT Artificial Sequence Core polypeptide 757Tyr Thr Ser Leu Ile His Ala Ala Ala Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Asn Trp Phe 35 758 36 PRT Artificial Sequence Core polypeptide 758Tyr Thr Ser Ala Ala Ala Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Asn Trp Phe 35 759 35 PRT Artificial Sequence Core polypeptide 759Glu Ile Trp Asn Asn Met Thr Trp Met Glu Trp Asp Arg Glu Asn Glu 1 5 10 15Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu 20 25 30His Asn Val 35 760 36 PRT Artificial Sequence Core polypeptide 760Tyr Ile Ser Glu Val Asn Glu Glu Ile Asn Gln Ser Leu Ala Phe Ile 1 5 10 15Arg Lys Ala Asp Glu Leu Leu Glu Asn Val Asp Lys Trp Ala Ser Leu 20 25 30Trp Asn Trp Phe 35 761 35 PRT Artificial Sequence Core polypeptide 761Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile Lys Glu Asn Lys Ala 1 5 10 15Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys Gln Glu Leu Asp Lys 20 25 30Tyr Lys Asn 35 762 38 PRT Artificial Sequence Core polypeptide 762Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Asn Trp Phe Met Gly 35 763 21 PRT Artificial Sequence Core polypeptide 763Asn Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu 1 5 10 15Leu Leu His Asn Val 20 764 35 PRT Artificial Sequence Core polypeptide 764Tyr Asp Pro Leu Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser 1 5 10 15Gln Val Asn Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser 20 25 30Asp Glu Leu 35 765 35 PRT Artificial Sequence Core polypeptide 765Pro Leu Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val 1 5 10 15Asn Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu 20 25 30Leu Leu His 35 766 35 PRT Artificial Sequence Core polypeptide 766Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn Glu 1 5 10 15Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu 20 25 30His Asn Val 35 767 35 PRT Artificial Sequence Core polypeptide 767Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln 1 5 10 15Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu His Asn Val Asn 20 25 30Ala Gly Lys 35 768 35 PRT Artificial Sequence Core polypeptide 768Val Tyr Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn Glu 1 5 10 15Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu 20 25 30His Asn Val 35 769 35 PRT Artificial Sequence Core polypeptide 769Val Tyr Pro Ser Asp Glu Tyr Asp Ala Ser Ile Ser Gln Val Asn Glu 1 5 10 15Glu Ile Asn Gln Ala Leu Ala Tyr Ile Arg Lys Ala Asp Glu Leu Leu 20 25 30Glu Asn Val 35 770 35 PRT Artificial Sequence Core polypeptide 770Val Tyr Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Gln Glu 1 5 10 15Glu Ile Gln Gln Ala Leu Ala Phe Ile Arg Lys Ala Asp Glu Leu Leu 20 25 30Glu Gln Val 35 771 37 PRT Artificial Sequence Core polypeptide 771Asn Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln 1 5 10 15Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser 20 25 30Leu Trp Asn Trp Phe 35 772 38 PRT Artificial Sequence Core polypeptide 772Asn Asn Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn 1 5 10 15Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala 20 25 30Ser Leu Trp Asn Trp Phe 35 773 39 PRT Artificial Sequence Core polypeptide 773Ile Asn Asn Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln 1 5 10 15Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp 20 25 30Ala Ser Leu Trp Asn Trp Phe 35 774 40 PRT Artificial Sequence Core polypeptide 774Glu Ile Asn Asn Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser 1 5 10 15Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys 20 25 30Trp Ala Ser Leu Trp Asn Trp Phe 35 40 775 37 PRT Artificial Sequence Core polypeptide 775Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Asn Trp Phe Asn 35 776 38 PRT Artificial Sequence Core polypeptide 776Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Asn Trp Phe Asn Ile 35 777 39 PRT Artificial Sequence Core polypeptide 777Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Asn Trp Phe Asn Ile Thr 35 778 40 PRT Artificial Sequence Core polypeptide 778Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Asn Trp Phe Asn Ile Thr Asn 35 40 779 43 PRT Artificial Sequence Core polypeptide 779Tyr Asp Pro Leu Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser 1 5 10 15Gln Val Asn Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser 20 25 30Asp Glu Leu Leu His Asn Val Asn Ala Gly Lys 35 40 780 38 PRT Artificial Sequence Core polypeptide 780Asn Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln 1 5 10 15Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser 20 25 30Leu Trp Asn Trp Phe Asn 35 781 40 PRT Artificial Sequence Core polypeptide 781Asn Asn Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn 1 5 10 15Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala 20 25 30Ser Leu Trp Asn Trp Phe Asn Ile 35 40 782 49 PRT Artificial Sequence Core polypeptide 782Lys Cys Arg Ala Lys Phe Lys Gln Leu Leu Gln His Tyr Arg Glu Val 1 5 10 15Ala Ala Ala Lys Ser Ser Glu Asn Asp Arg Leu Arg Leu Leu Leu Lys 20 25 30Gln Met Cys Pro Ser Leu Asp Val Asp Ser Ile Ile Pro Arg Thr Pro 35 40 45Asp 783 47 PRT Artificial Sequence Core polypeptide 783Arg Ala Lys Phe Lys Gln Leu Leu Gln His Tyr Arg Glu Val Ala Ala 1 5 10 15Ala Lys Ser Ser Glu Asn Asp Arg Leu Arg Leu Leu Leu Lys Gln Met 20 25 30Cys Pro Ser Leu Asp Val Asp Ser Ile Ile Pro Arg Thr Pro Asp 35 40 45 784 35 PRT Artificial Sequence Core polypeptide 784Val Tyr Pro Ser Asp Glu Tyr Asp Ala Ser Ile Ser Gln Val Asn Glu 1 5 10 15Glu Ile Asn Gln Ala Leu Ala Tyr Ile Ala Ala Ala Asp Glu Leu Leu 20 25 30Glu Asn Val 35 785 26 PRT Artificial Sequence Core polypeptide 785Tyr Asp Ala Ser Ile Ser Gln Val Asn Glu Glu Ile Asn Gln Ala Leu 1 5 10 15Ala Tyr Ile Arg Lys Ala Asp Glu Leu Leu 20 25 786 40 PRT Artificial Sequence Core polypeptide 786Met Asn Leu Glu Trp Met Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr 1 5 10 15Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys 20 25 30Asn Glu Gln Glu Leu Leu Glu Leu 35 40 787 34 PRT Artificial Sequence Core polypeptide 787Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Glu Glu Glu Ser Lys Leu 1 5 10 15Asn Arg Asn Glu Ile Lys Gly Val Lys Leu Ser Ser Met Gly Val Tyr 20 25 30Gln Ile 788 35 PRT Artificial Sequence Core polypeptide 788Val Thr Glu Lys Ile Gln Met Ala Ser Asp Asn Ile Asn Asp Leu Ile 1 5 10 15Gln Ser Gly Val Asn Thr Arg Leu Leu Thr Ile Gln Ser His Val Gln 20 25 30Asn Tyr Ile 35 789 24 PRT Artificial Sequence Core polypeptide 789Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys 1 5 10 15Trp Ala Ser Leu Trp Asn Trp Phe 20 790 24 PRT Artificial Sequence Core polypeptide 790Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys 1 5 10 15Trp Ala Ser Leu Trp Asn Trp Phe 20 791 5 PRT Artificial Sequence Core polypeptide 791Leu Trp Asn Trp Phe 1 5 792 15 PRT Artificial Sequence Core polypeptide 792Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe 1 5 10 15 793 20 PRT Artificial Sequence Core polypeptide 793Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 1 5 10 15Trp Asn Trp Phe 20 794 30 PRT Artificial Sequence Core polypeptide 794Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu 1 5 10 15Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe 20 25 30 795 35 PRT Artificial Sequence Core polypeptide 795Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Asn Trp 35 796 34 PRT Artificial Sequence Core polypeptide 796Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Asn 797 33 PRT Artificial Sequence Core polypeptide 797Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp 798 32 PRT Artificial Sequence Core polypeptide 798Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30 799 35 PRT Artificial Sequence Core polypeptide 799Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu 1 5 10 15Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp 20 25 30Asn Trp Phe 35 800 34 PRT Artificial Sequence Core polypeptide 800Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys 1 5 10 15Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn 20 25 30Trp Phe 801 33 PRT Artificial Sequence Core polypeptide 801Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn 1 5 10 15Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp 20 25 30Phe 802 32 PRT Artificial Sequence Core polypeptide 802Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu 1 5 10 15Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe 20 25 30 803 51 PRT Artificial Sequence Core polypeptide 803Ala Ala Val Ala Leu Leu Pro Ala Val Leu Leu Ala Leu Leu Ala Pro 1 5 10 15Ser Glu Leu Glu Ile Lys Arg Tyr Lys Asn Arg Val Ala Ser Arg Lys 20 25 30Cys Arg Ala Lys Phe Lys Gln Leu Leu Gln His Tyr Arg Glu Val Ala 35 40 45Ala Ala Lys 50 804 51 PRT Artificial Sequence Core polypeptide 804Ala Ala Val Ala Leu Leu Pro Ala Val Leu Leu Ala Leu Leu Ala Pro 1 5 10 15Cys Arg Ala Lys Phe Lys Gln Leu Leu Gln His Tyr Arg Glu Val Ala 20 25 30Ala Ala Lys Ser Ser Glu Asn Asp Arg Leu Arg Leu Leu Leu Lys Gln 35 40 45Met Cys Pro 50 805 36 PRT Artificial Sequence Core polypeptide 805Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Asn Asn Ile Glu Arg Asp Trp Glu Met Trp Thr Met Asn 20 25 30Asn Trp Ile Gln 35 806 35 PRT Artificial Sequence Core polypeptide 806Val Tyr Pro Ser Asp Glu Tyr Asp Ala Ser Ile Ser Gln Val Asn Glu 1 5 10 15Glu Ile Asn Gln Ala Leu Ala Tyr Ile Arg Lys Ala Asp Glu Leu Leu 20 25 30Glu Asn Val 35 807 35 PRT Artificial Sequence Core polypeptide 807Leu Met Gln Leu Ala Arg Gln Leu Met Gln Leu Ala Arg Gln Met Lys 1 5 10 15Gln Leu Ala Asp Ser Leu Met Gln Leu Ala Arg Gln Val Ser Arg Leu 20 25 30Glu Ser Ala 35 808 34 PRT Artificial Sequence Core polypeptide 808Trp Met Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser Leu Ile His 1 5 10 15Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu 20 25 30Leu Leu 809 35 PRT Artificial Sequence Core polypeptide 809Met Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser Leu Ile His Ser 1 5 10 15Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu 20 25 30Leu Glu Leu 35 810 34 PRT Artificial Sequence Core polypeptide 810Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser Leu Ile His Ser Leu 1 5 10 15Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu 20 25 30Glu Leu 811 34 PRT Artificial Sequence Core polypeptide 811Met Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser Leu Ile His Ser 1 5 10 15Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu 20 25 30Leu Glu 812 36 PRT Artificial Sequence Core polypeptide 812Trp Asn Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser Leu Ile His 1 5 10 15Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu 20 25 30Leu Leu Glu Leu 35 813 36 PRT Artificial Sequence Core polypeptide 813Tyr Leu Glu Tyr Asp Arg Glu Ile Asn Asn Tyr Thr Ser Leu Ile His 1 5 10 15Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu 20 25 30Leu Leu Glu Leu 35 814 17 PRT Artificial Sequence Core polypeptide 814Ile Lys Gln Phe Ile Asn Met Trp Gln Glu Val Gly Lys Ala Met Tyr 1 5 10 15Ala 815 8 PRT Artificial Sequence Core polypeptide 815Ile Arg Lys Ser Asp Glu Leu Leu 1 5 816 8 PRT Artificial Sequence Core polypeptide 816Tyr Asp Ala Ser Ile Ser Gln Val 1 5 817 8 PRT Artificial Sequence Core polypeptide 817Asn Glu Lys Ile Asn Gln Ser Leu 1 5 818 23 PRT Artificial Sequence Core polypeptide 818Ser Ile Ser Gln Val Asn Glu Glu Ile Asn Gln Ala Leu Ala Tyr Ile 1 5 10 15Arg Lys Ala Asp Glu Leu Leu 20 819 20 PRT Artificial Sequence Core polypeptide 819Gln Val Asn Glu Glu Ile Asn Gln Ala Leu Ala Tyr Ile Arg Lys Ala 1 5 10 15Asp Glu Leu Leu 20 820 17 PRT Artificial Sequence Core polypeptide 820Glu Glu Ile Asn Gln Ala Leu Ala Tyr Ile Arg Lys Ala Asp Glu Leu 1 5 10 15Leu 821 14 PRT Artificial Sequence Core polypeptide 821Asn Gln Ala Leu Ala Tyr Ile Arg Lys Ala Asp Glu Leu Leu 1 5 10 822 11 PRT Artificial Sequence Core polypeptide 822Leu Ala Tyr Ile Arg Lys Ala Asp Glu Leu Leu 1 5 10 823 26 PRT Artificial Sequence Core polypeptide 823Phe Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ala Leu 1 5 10 15Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu 20 25 824 36 PRT Artificial Sequence Core polypeptide 824Trp Asn Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser Leu Ile His 1 5 10 15Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu 20 25 30Leu Leu Glu Leu 35 825 45 PRT Artificial Sequence Core polypeptide 825Ala Ser Arg Lys Cys Arg Ala Lys Phe Lys Gln Leu Leu Gln His Tyr 1 5 10 15Arg Glu Val Ala Ala Ala Lys Ser Ser Glu Asn Asp Arg Leu Arg Leu 20 25 30Leu Leu Lys Gln Met Cys Pro Ser Leu Asp Val Asp Ser 35 40 45 826 4 PRT Artificial Sequence Core polypeptide 826Glx Phe Phe Gly 1 827 36 PRT Artificial Sequence Core polypeptide 827Trp Leu Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser Leu Ile His 1 5 10 15Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu 20 25 30Leu Leu Glu Leu 35 828 36 PRT Artificial Sequence Core polypeptide 828Tyr Val Lys Gly Glu Pro Ile Ile Asn Phe Tyr Asp Pro Leu Val Phe 1 5 10 15Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile 20 25 30Asn Gln Ser Leu 35 829 35 PRT Artificial Sequence Core polypeptide 829Val Tyr Pro Ser Asp Glu Tyr Asp Ala Ser Ile Ser Gln Val Asn Glu 1 5 10 15Glu Ile Asn Gln Ser Leu Ala Tyr Ile Arg Lys Ala Asp Glu Leu Leu 20 25 30His Asn Val 35 830 29 PRT Artificial Sequence Core polypeptide 830Tyr Asp Ala Ser Ile Ser Gln Val Asn Glu Glu Ile Asn Gln Ala Leu 1 5 10 15Ala Tyr Ile Arg Lys Ala Asp Glu Leu Leu Glu Asn Val 20 25 831 27 PRT Artificial Sequence Core polypeptide 831Tyr Asp Ala Ser Ile Ser Gln Val Asn Glu Glu Ile Asn Gln Ala Leu 1 5 10 15Ala Tyr Ile Arg Lys Ala Asp Glu Leu Leu Glu 20 25 832 35 PRT Artificial Sequence Core polypeptide 832Val Tyr Pro Ser Asp Glu Tyr Asp Ala Ser Ile Ser Gln Val Asn Glu 1 5 10 15Glu Ile Asn Gln Ala Leu Ala Tyr Ile Arg Lys Ala Ala Glu Leu Leu 20 25 30His Asn Val 35 833 35 PRT Artificial Sequence Core polypeptide 833Val Tyr Pro Ser Asp Glu Tyr Asp Ala Ser Ile Ser Gln Val Asn Glu 1 5 10 15Glu Ile Asn Gln Ala Leu Ala Tyr Ile Arg Lys Ala Leu Glu Leu Leu 20 25 30His Asn Val 35 834 36 PRT Artificial Sequence Core polypeptide 834Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Asn Trp Phe 35 835 35 PRT Artificial Sequence Core polypeptide 835Val Tyr Pro Ser Asp Glu Tyr Asp Ala Ser Ile Ser Gln Val Asn Glu 1 5 10 15Glu Ile Asn Gln Leu Leu Ala Tyr Ile Arg Lys Leu Asp Glu Leu Leu 20 25 30Glu Asn Val 35 836 28 PRT Artificial Sequence Core polypeptide 836Asp Glu Tyr Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln 1 5 10 15Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu 20 25 837 35 PRT Artificial Sequence Core polypeptide 837Ser Asn Asp Gln Gly Ser Gly Tyr Ala Ala Asp Lys Glu Ser Thr Gln 1 5 10 15Lys Ala Phe Asp Gly Ile Thr Asn Lys Val Asn Ser Val Ile Glu Lys 20 25 30Thr Asn Thr 35 838 38 PRT Artificial Sequence Core polypeptide 838Glu Ser Thr Gln Lys Ala Phe Asp Gly Ile Thr Asn Lys Val Asn Ser 1 5 10 15Val Ile Glu Lys Thr Asn Thr Gln Phe Glu Ala Val Gly Lys Glu Phe 20 25 30Gly Asn Leu Glu Lys Arg 35 839 37 PRT Artificial Sequence Core polypeptide 839Asp Gly Ile Thr Asn Lys Val Asn Ser Val Ile Glu Lys Thr Asn Thr 1 5 10 15Gln Phe Glu Ala Val Gly Lys Glu Phe Gly Asn Leu Glu Lys Arg Leu 20 25 30Glu Asn Leu Asn Lys 35 840 32 PRT Artificial Sequence Core polypeptide 840Asp Ser Asn Val Lys Asn Leu Tyr Asp Lys Val Arg Ser Gln Leu Arg 1 5 10 15Asp Asn Val Lys Glu Leu Gly Asn Gly Ala Phe Glu Phe Tyr His Lys 20 25 30 841 36 PRT Artificial Sequence Core polypeptide 841Arg Asp Asn Val Lys Glu Leu Gly Asn Gly Ala Phe Glu Phe Tyr His 1 5 10 15Lys Ala Asp Asp Glu Ala Leu Asn Ser Val Lys Asn Gly Thr Tyr Asp 20 25 30Tyr Pro Lys Tyr 35 842 24 PRT Artificial Sequence Core polypeptide 842Glu Phe Tyr His Lys Ala Asp Asp Glu Ala Leu Asn Ser Val Lys Asn 1 5 10 15Gly Thr Tyr Asp Tyr Pro Lys Tyr 20 843 36 PRT Artificial Sequence Core polypeptide 843Ala Ala Val Ala Leu Leu Pro Ala Val Leu Leu Ala Leu Leu Ala Pro 1 5 10 15Ala Ala Asp Lys Glu Ser Thr Gln Lys Ala Phe Asp Gly Ile Thr Asn 20 25 30Lys Val Asn Ser 35 844 36 PRT Artificial Sequence Core polypeptide 844Ala Ala Val Ala Leu Leu Pro Ala Val Leu Leu Ala Leu Leu Ala Pro 1 5 10 15Ala Ala Asp Ser Asn Val Lys Asn Leu Tyr Asp Lys Val Arg Ser Gln 20 25 30Leu Arg Asp Asn 35 845 18 PRT Artificial Sequence Core polypeptide 845Lys Glu Ser Thr Gln Lys Ala Phe Asp Gly Ile Thr Asn Lys Val Asn 1 5 10 15Ser Val 846 20 PRT Artificial Sequence Core polypeptide 846Ile Glu Lys Thr Asn Thr Gln Phe Glu Ala Val Gly Lys Glu Phe Gly 1 5 10 15Asn Leu Glu Arg 20 847 30 PRT Artificial Sequence Core polypeptide 847Arg Leu Glu Asn Leu Asn Lys Arg Val Glu Asp Gly Phe Leu Asp Val 1 5 10 15Trp Thr Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu Asn Glu 20 25 30 848 17 PRT Artificial Sequence Core polypeptide 848Ser Asn Val Lys Asn Leu Tyr Asp Lys Val Arg Ser Gln Leu Arg Asp 1 5 10 15Asn 849 33 PRT Artificial Sequence Core polypeptide 849Trp Met Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser Leu Ile His 1 5 10 15Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu 20 25 30Leu 850 32 PRT Artificial Sequence Core polypeptide 850Trp Met Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser Leu Ile His 1 5 10 15Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu 20 25 30 851 32 PRT Artificial Sequence Core polypeptide 851Met Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser Leu Ile His Ser 1 5 10 15Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu 20 25 30 852 31 PRT Artificial Sequence Core polypeptide 852Met Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser Leu Ile His Ser 1 5 10 15Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu 20 25 30 853 33 PRT Artificial Sequence Core polypeptide 853Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser Leu Ile His Ser Leu 1 5 10 15Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu 20 25 30Glu 854 32 PRT Artificial Sequence Core polypeptide 854Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser Leu Ile His Ser Leu 1 5 10 15Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu 20 25 30 855 31 PRT Artificial Sequence Core polypeptide 855Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser Leu Ile His Ser Leu 1 5 10 15Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu 20 25 30 856 36 PRT Artificial Sequence Core polypeptide 856Tyr Thr Lys Phe Ile Tyr Thr Leu Leu Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Asn Trp Phe 35 857 22 PRT Artificial Sequence Core polypeptide 857Tyr Met Lys Gln Leu Ala Asp Ser Leu Met Gln Leu Ala Arg Gln Val 1 5 10 15Ser Arg Leu Glu Ser Ala 20 858 29 PRT Artificial Sequence Core polypeptide 858Tyr Leu Met Gln Leu Ala Arg Gln Met Lys Gln Leu Ala Asp Ser Leu 1 5 10 15Met Gln Leu Ala Arg Gln Val Ser Arg Leu Glu Ser Ala 20 25 859 36 PRT Artificial Sequence Core polypeptide 859Tyr Gln Glu Trp Glu Arg Lys Val Asp Phe Leu Glu Glu Asn Ile Thr 1 5 10 15Ala Leu Leu Glu Glu Ala Gln Ile Gln Gln Glu Lys Asn Met Tyr Glu 20 25 30Leu Gln Lys Leu 35 860 36 PRT Artificial Sequence Core polypeptide 860Trp Met Ala Trp Ala Ala Ala Ile Asn Asn Tyr Thr Ser Leu Ile His 1 5 10 15Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu 20 25 30Glu Glu Glu Glu 35 861 36 PRT Artificial Sequence Core polypeptide 861Tyr Ala Ser Leu Ile Ala Ala Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Ala Lys Trp Ala Ala Leu 20 25 30Trp Ala Trp Phe 35 862 38 PRT Artificial Sequence Core polypeptide 862Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser Leu Ile His Ser Leu 1 5 10 15Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Gly Gly 20 25 30Cys Asp Ile Met Glu Arg 35 863 35 PRT Artificial Sequence Core polypeptide 863Tyr Asp Ile Ser Ile Glu Leu Asn Lys Ala Lys Ser Asp Leu Glu Glu 1 5 10 15Ser Lys Glu Trp Ile Lys Lys Ser Asn Gln Lys Leu Asp Ser Ile Gly 20 25 30Asn Trp His 35 864 35 PRT Artificial Sequence Core polypeptide 864Ile Asp Ile Ser Ile Glu Leu Asn Lys Ala Lys Ser Asp Leu Glu Glu 1 5 10 15Ser Lys Glu Trp Ile Lys Lys Ser Asn Gln Lys Leu Asp Ser Ile Gly 20 25 30Asn Trp His 35 865 6 PRT Artificial Sequence Core polypeptide 865Tyr Thr Ser Leu Ile His 1 5 866 7 PRT Artificial Sequence Core polypeptide 866His Ser Leu Ile Glu Glu His 1 5 867 8 PRT Artificial Sequence Core polypeptide 867Ser Gln Asn Gln Gln Glu Lys His 1 5 868 9 PRT Artificial Sequence Core polypeptide 868Asn Glu Gln Glu Leu Leu Glu Leu His 1 5 869 7 PRT Artificial Sequence Core polypeptide 869Asp Lys Trp Ala Ser Leu His 1 5 870 5 PRT Artificial Sequence Core polypeptide 870Trp Asn Trp Phe His 1 5 871 36 PRT Artificial Sequence Core polypeptide 871Ala Lys Thr Leu Glu Arg Thr Trp Asp Thr Leu Asn His Leu Leu Phe 1 5 10 15Ile Ser Ser Ala Leu Tyr Lys Leu Asn Leu Lys Ser Val Ala Gln Ile 20 25 30Thr Leu Ser Ile 35 872 24 PRT Artificial Sequence Core polypeptide 872Asn Ile Thr Leu Gln Ala Lys Ile Lys Gln Phe Ile Asn Met Trp Gln 1 5 10 15Glu Val Gly Lys Ala Met Tyr Ala 20 873 28 PRT Artificial Sequence Core polypeptide 873Leu Glu Asn Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn 1 5 10 15Leu Tyr Asp Lys Val Arg Leu Gln Leu Arg Asp Asn 20 25 874 35 PRT Artificial Sequence Core polypeptide 874Leu Glu Asn Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn 1 5 10 15Leu Tyr Asp Lys Val Arg Leu Gln Leu Arg Asp Asn Val Lys Glu Leu 20 25 30Gly Asn Gly 35 875 34 PRT Artificial Sequence Core polypeptide 875Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Asp Lys Val 1 5 10 15Arg Leu Gln Leu Arg Asp Asn Val Lys Glu Leu Gly Asn Gly Ala Phe 20 25 30Glu Phe 876 26 PRT Artificial Sequence Core polypeptide 876Phe Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ala Leu 1 5 10 15Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu 20 25 877 23 PRT Artificial Sequence Core polypeptide 877Ser Ile Ser Gln Val Asn Glu Glu Ile Asn Gln Ala Leu Ala Tyr Ile 1 5 10 15Arg Lys Ala Asp Glu Leu Leu 20 878 23 PRT Artificial Sequence Core polypeptide 878Ser Ile Ser Gln Val Asn Glu Glu Ile Asn Gln Ser Leu Ala Tyr Ile 1 5 10 15Arg Lys Ser Asp Glu Leu Leu 20 879 23 PRT Artificial Sequence Core polypeptide 879Ser Ile Ser Gln Val Asn Glu Glu Ile Asn Gln Ser Leu Ala Tyr Ile 1 5 10 15Arg Lys Ser Asp Glu Leu Leu 20 880 35 PRT Artificial Sequence Core polypeptide 880Asn Ser Val Ala Leu Asp Pro Ile Asp Ile Ser Ile Glu Leu Asn Lys 1 5 10 15Ala Lys Ser Asp Leu Glu Glu Ser Lys Glu Trp Ile Lys Lys Ser Asn 20 25 30Gln Lys Leu 35 881 35 PRT Artificial Sequence Core polypeptide 881Ala Leu Asp Pro Ile Asp Ile Ser Ile Glu Leu Asn Lys Ala Lys Ser 1 5 10 15Asp Leu Glu Glu Ser Lys Glu Trp Ile Lys Lys Ser Asn Gln Lys Leu 20 25 30Asp Ser Ile 35 882 35 PRT Artificial Sequence Core polypeptide 882Asn Ser Val Ala Leu Asp Pro Ile Asp Ile Ser Ile Glu Leu Asn Lys 1 5 10 15Ala Lys Ser Asp Leu Glu Glu Ser Lys Glu Trp Ile Lys Lys Ser Asn 20 25 30Gln Lys Leu 35 883 35 PRT Artificial Sequence Core polypeptide 883Ala Leu Asp Pro Ile Asp Ile Ser Ile Glu Leu Asn Lys Ala Lys Ser 1 5 10 15Asp Leu Glu Glu Ser Lys Glu Trp Ile Lys Lys Ser Asn Gln Lys Leu 20 25 30Asp Ser Ile 35 884 26 PRT Artificial Sequence Core polypeptide 884Tyr Asp Ala Ser Ile Ser Gln Val Asn Glu Glu Ile Asn Gln Ala Leu 1 5 10 15Ala Tyr Ile Arg Lys Ala Asp Glu Leu Leu 20 25 885 26 PRT Artificial Sequence Core polypeptide 885Tyr Asp Ala Ser Ile Ser Gln Val Asn Glu Glu Ile Asn Gln Ser Leu 1 5 10 15Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu 20 25 886 26 PRT Artificial Sequence Core polypeptide 886Tyr Asp Ala Ser Ile Ser Gln Val Asn Glu Glu Ile Asn Gln Ser Leu 1 5 10 15Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu 20 25 887 33 PRT Artificial Sequence Core polypeptide 887Trp Leu Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser Leu Ile His 1 5 10 15Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu 20 25 30Leu 888 35 PRT Artificial Sequence Core polypeptide 888Ile Asp Ile Ser Ile Glu Leu Asn Lys Ala Lys Ser Asp Leu Glu Glu 1 5 10 15Ser Lys Glu Trp Ile Arg Arg Ser Asn Gln Lys Leu Asp Ser Ile Gly 20 25 30Asn Trp His 35 889 35 PRT Artificial Sequence Core polypeptide 889Asn Ser Val Ala Leu Asp Pro Ile Asp Ile Ser Ile Glu Leu Asn Lys 1 5 10 15Ala Lys Ser Asp Leu Glu Glu Ser Lys Glu Trp Ile Lys Lys Ser Asn 20 25 30Gln Lys Leu 35 890 26 PRT Artificial Sequence Core polypeptide 890Tyr Asp Ala Ser Ile Ser Gln Val Asn Glu Glu Ile Asn Gln Ala Leu 1 5 10 15Ala Tyr Ile Arg Lys Ala Asp Glu Leu Leu 20 25 891 28 PRT Artificial Sequence Core polypeptide 891Asp Glu Tyr Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln 1 5 10 15Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu 20 25 892 33 PRT Artificial Sequence Core polypeptide 892Trp Gln Glu Trp Glu Gln Lys Val Arg Tyr Leu Glu Ala Asn Ile Ser 1 5 10 15Gln Ser Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Asn Met Tyr Glu 20 25 30Leu 893 33 PRT Artificial Sequence Core polypeptide 893Trp Gln Glu Trp Glu Gln Lys Val Arg Tyr Leu Glu Ala Asn Ile Ser 1 5 10 15Gln Ser Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Asn Glu Tyr Glu 20 25 30Leu 894 33 PRT Artificial Sequence Core polypeptide 894Trp Gln Glu Trp Glu Gln Lys Val Arg Tyr Leu Glu Ala Asn Ile Thr 1 5 10 15Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Asn Glu Tyr Glu 20 25 30Leu 895 33 PRT Artificial Sequence Core polypeptide 895Trp Gln Glu Trp Glu Gln Lys Val Arg Tyr Leu Glu Ala Asn Ile Thr 1 5 10 15Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Asn Met Tyr Glu 20 25 30Leu 896 36 PRT Artificial Sequence Core polypeptide 896Trp Gln Glu Trp Glu Gln Lys Val Arg Tyr Leu Glu Ala Asn Ile Ser 1 5 10 15Gln Ser Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Asn Glu Tyr Glu 20 25 30Leu Gln Lys Leu 35 897 36 PRT Artificial Sequence Core polypeptide 897Trp Gln Glu Trp Glu Gln Lys Val Arg Tyr Leu Glu Ala Asn Ile Thr 1 5 10 15Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Asn Glu Tyr Glu 20 25 30Leu Gln Lys Leu 35 898 36 PRT Artificial Sequence Core polypeptide 898Trp Gln Glu Trp Glu Gln Lys Val Arg Tyr Leu Glu Ala Asn Ile Thr 1 5 10 15Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Asn Met Tyr Glu 20 25 30Leu Gln Lys Leu 35 899 37 PRT Artificial Sequence Core polypeptide 899Glu Phe Gly Asn Leu Glu Lys Arg Leu Glu Asn Leu Asn Lys Arg Val 1 5 10 15Glu Asp Gly Phe Leu Asp Val Trp Thr Tyr Asn Ala Glu Leu Leu Val 20 25 30Ala Leu Glu Asn Glu 35 900 42 PRT Artificial Sequence Core polypeptide 900Glu Asp Gly Phe Leu Asp Val Trp Thr Tyr Asn Ala Glu Leu Leu Val 1 5 10 15Leu Met Glu Asn Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys 20 25 30Asn Leu Tyr Asp Lys Val Arg Met Gln Leu 35 40 901 23 PRT Artificial Sequence Core polypeptide 901Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile 1 5 10 15Arg Lys Ser Asp Glu Leu Leu 20 902 23 PRT Artificial Sequence Core polypeptide 902Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile 1 5 10 15Arg Lys Ser Asp Glu Leu Leu 20 903 23 PRT Artificial Sequence Core polypeptide 903Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser Leu Ala Tyr Ile 1 5 10 15Arg Lys Ser Asp Glu Leu Leu 20 904 38 PRT Artificial Sequence Core polypeptide 904Gln Gln Leu Leu Asp Val Val Lys Arg Gln Gln Glu Met Leu Arg Leu 1 5 10 15Thr Val Trp Gly Thr Lys Asn Leu Gln Ala Arg Val Thr Ala Ile Glu 20 25 30Lys Tyr Leu Lys Asp Gln 35 905 37 PRT Artificial Sequence Core polypeptide 905Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Asn Trp Phe Cys 35 906 26 PRT Artificial Sequence Core polypeptide 906Phe Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser Leu 1 5 10 15Ala Tyr Ile Arg Lys Ser Asp Glu Leu Leu 20 25 907 30 PRT Artificial Sequence Core polypeptide 907Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala 20 25 30 908 28 PRT Artificial Sequence Core polypeptide 908Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln 1 5 10 15Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu 20 25 909 28 PRT Artificial Sequence Core polypeptide 909Asp Glu Phe Asp Glu Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln 1 5 10 15Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu 20 25 910 28 PRT Artificial Sequence Core polypeptide 910Asp Glu Phe Asp Glu Ser Ile Ser Gln Val Asn Glu Lys Ile Glu Gln 1 5 10 15Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu 20 25 911 28 PRT Artificial Sequence Core polypeptide 911Asp Glu Phe Asp Glu Ser Ile Ser Gln Val Asn Glu Lys Ile Glu Glu 1 5 10 15Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu 20 25 912 28 PRT Artificial Sequence Core polypeptide 912Asp Glu Phe Asp Glu Ser Ile Ser Gln Val Asn Glu Lys Ile Glu Glu 1 5 10 15Ser Leu Gln Phe Ile Arg Lys Ser Asp Glu Leu Leu 20 25 913 33 PRT Artificial Sequence Core polypeptide 913Gly Gly Gly Gly Gly Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn 1 5 10 15Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu 20 25 30Leu 914 28 PRT Artificial Sequence Core polypeptide 914Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln 1 5 10 15Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu 20 25 915 28 PRT Artificial Sequence Core polypeptide 915Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln 1 5 10 15Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu 20 25 916 35 PRT Artificial Sequence Core polypeptide 916Ala Leu Asp Pro Ile Asp Ile Ser Ile Glu Leu Asn Lys Ala Lys Ser 1 5 10 15Asp Leu Glu Glu Ser Lys Glu Trp Ile Arg Arg Ser Asn Gln Lys Leu 20 25 30Asp Ser Ile 35 917 35 PRT Artificial Sequence Core polypeptide 917Tyr Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ala Leu 1 5 10 15Ala Tyr Ile Arg Lys Ala Asp Glu Leu Leu His Asn Val Asn Ala Gly 20 25 30Lys Ser Thr 35 918 35 PRT Artificial Sequence Core polypeptide 918Val Tyr Pro Ser Asp Glu Tyr Asp Ala Ser Ile Ser Gln Val Asn Glu 1 5 10 15Lys Ile Asn Gln Ala Leu Ala Tyr Ile Arg Lys Ala Asp Glu Leu Leu 20 25 30His Asn Val 35 919 8 PRT Artificial Sequence Core polypeptide 919Trp Gly Trp Gly Tyr Gly Tyr Gly 1 5 920 9 PRT Artificial Sequence Core polypeptide 920Tyr Gly Trp Gly Trp Gly Trp Gly Phe 1 5 921 36 PRT Artificial Sequence Core polypeptide 921Trp Gln Glu Trp Glu Gln Lys Val Arg Tyr Leu Glu Ala Asn Ile Thr 1 5 10 15Ala Leu Gln Glu Gln Ala Gln Ile Gln Ala Glu Lys Ala Glu Tyr Glu 20 25 30Leu Gln Lys Leu 35 922 36 PRT Artificial Sequence Core polypeptide 922Trp Gln Glu Trp Glu Gln Lys Val Arg Tyr Leu Glu Ala Glu Ile Thr 1 5 10 15Ala Leu Gln Glu Glu Ala Gln Ile Gln Ala Glu Lys Ala Glu Tyr Glu 20 25 30Leu Gln Lys Leu 35 923 31 PRT Artificial Sequence Core polypeptide 923Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser 20 25 30 924 35 PRT Artificial Sequence Core polypeptide 924Val Trp Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn Glu 1 5 10 15Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu 20 25 30His Asn Val 35 925 35 PRT Artificial Sequence Core polypeptide 925Ser Lys Asn Ile Ser Glu Gln Ile Asp Gln Ile Lys Lys Asp Glu Gln 1 5 10 15Lys Glu Gly Thr Gly Trp Gly Leu Gly Gly Lys Trp Trp Thr Ser Asp 20 25 30Trp Gly Val 35 926 35 PRT Artificial Sequence Core polypeptide 926Leu Ser Lys Asn Ile Ser Glu Gln Ile Asp Gln Ile Lys Lys Asp Glu 1 5 10 15Gln Lys Glu Gly Thr Gly Trp Gly Leu Gly Gly Lys Trp Trp Thr Ser 20 25 30Asp Trp Gly 35 927 35 PRT Artificial Sequence Core polypeptide 927Asp Leu Ser Lys Asn Ile Ser Glu Gln Ile Asp Gln Ile Lys Lys Asp 1 5 10 15Glu Gln Lys Glu Gly Thr Gly Trp Gly Leu Gly Gly Lys Trp Trp Thr 20 25 30Ser Asp Trp 35 928 35 PRT Artificial Sequence Core polypeptide 928Glu Asp Leu Ser Lys Asn Ile Ser Glu Gln Ile Asp Gln Ile Lys Lys 1 5 10 15Asp Glu Gln Lys Glu Gly Thr Gly Trp Gly Leu Gly Gly Lys Trp Trp 20 25 30Thr Ser Asp 35 929 35 PRT Artificial Sequence Core polypeptide 929Ile Glu Asp Leu Ser Lys Asn Ile Ser Glu Gln Ile Asp Gln Ile Lys 1 5 10 15Lys Asp Glu Gln Lys Glu Gly Thr Gly Trp Gly Leu Gly Gly Lys Trp 20 25 30Trp Thr Ser 35 930 35 PRT Artificial Sequence Core polypeptide 930Gly Ile Glu Asp Leu Ser Lys Asn Ile Ser Glu Gln Ile Asp Gln Ile 1 5 10 15Lys Lys Asp Glu Gln Lys Glu Gly Thr Gly Trp Gly Leu Gly Gly Lys 20 25 30Trp Trp Thr 35 931 35 PRT Artificial Sequence Core polypeptide 931Ile Gly Ile Glu Asp Leu Ser Lys Asn Ile Ser Glu Gln Ile Asp Gln 1 5 10 15Ile Lys Lys Asp Glu Gln Lys Glu Gly Thr Gly Trp Gly Leu Gly Gly 20 25 30Lys Trp Trp 35 932 34 PRT Artificial Sequence Core polypeptide 932Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile 1 5 10 15Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu His Asn 20 25 30Val Asn 933 35 PRT Artificial Sequence Core polypeptide 933Val Tyr Pro Ser Asp Glu Tyr Asp Ala Ser Ile Ser Gln Val Asn Glu 1 5 10 15Lys Ile Asn Gln Ala Leu Ala Tyr Ile Arg Lys Ala Asp Glu Leu Leu 20 25 30Glu Asn Val 35 934 35 PRT Artificial Sequence Core polypeptide 934Val Tyr Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn Glu 1 5 10 15Lys Ile Asn Gln Ala Leu Ala Phe Ile Arg Lys Ala Asp Glu Leu Leu 20 25 30Glu Asn Val 35 935 35 PRT Artificial Sequence Core polypeptide 935Val Tyr Pro Ser Asp Glu Tyr Asp Ala Ser Ile Ser Gln Val Asn Glu 1 5 10 15Lys Ile Asn Gln Ala Leu Ala Tyr Ile Arg Glu Ala Asp Glu Leu Leu 20 25 30Glu Asn Val 35 936 26 PRT Artificial Sequence Core polypeptide 936Tyr Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser Leu 1 5 10 15Ala Phe Ile Arg Glu Ser Asp Glu Leu Leu 20 25 937 35 PRT Artificial Sequence Core polypeptide 937Ala Ile Gly Ile Glu Asp Leu Ser Lys Asn Ile Ser Glu Gln Ile Asp 1 5 10 15Gln Ile Lys Lys Asp Glu Gln Lys Glu Gly Thr Gly Trp Gly Leu Gly 20 25 30Gly Lys Trp 35 938 35 PRT Artificial Sequence Core polypeptide 938Ala Ala Ile Gly Ile Glu Asp Leu Ser Lys Asn Ile Ser Glu Gln Ile 1 5 10 15Asp Gln Ile Lys Lys Asp Glu Gln Lys Glu Gly Thr Gly Trp Gly Leu 20 25 30Gly Gly Lys 35 939 35 PRT Artificial Sequence Core polypeptide 939Asp Ala Ala Ile Gly Ile Glu Asp Leu Ser Lys Asn Ile Ser Glu Gln 1 5 10 15Ile Asp Gln Ile Lys Lys Asp Glu Gln Lys Glu Gly Thr Gly Trp Gly 20 25 30Leu Gly Gly 35 940 35 PRT Artificial Sequence Core polypeptide 940Pro Asp Ala Ala Ile Gly Ile Glu Asp Leu Ser Lys Asn Ile Ser Glu 1 5 10 15Gln Ile Asp Gln Ile Lys Lys Asp Glu Gln Lys Glu Gly Thr Gly Trp 20 25 30Gly Leu Gly 35 941 35 PRT Artificial Sequence Core polypeptide 941Asn Ile Thr Asp Lys Ile Asp Gln Ile Ile His Asp Phe Val Asp Lys 1 5 10 15Thr Leu Pro Asp Gln Gly Asp Asn Asp Asn Trp Trp Thr Gly Trp Arg 20 25 30Gln Trp Ile 35 942 35 PRT Artificial Sequence Core polypeptide 942Lys Asn Ile Thr Asp Lys Ile Asp Gln Ile Ile His Asp Phe Val Asp 1 5 10 15Lys Thr Leu Pro Asp Gln Gly Asp Asn Asp Asn Trp Trp Thr Gly Trp 20 25 30Arg Gln Trp 35 943 35 PRT Artificial Sequence Core polypeptide 943Thr Lys Asn Ile Thr Asp Lys Ile Asp Gln Ile Ile His Asp Phe Val 1 5 10 15Asp Lys Thr Leu Pro Asp Gln Gly Asp Asn Asp Asn Trp Trp Thr Gly 20 25 30Trp Arg Gln 35 944 35 PRT Artificial Sequence Core polypeptide 944Trp Thr Lys Asn Ile Thr Asp Lys Ile Asp Gln Ile Ile His Asp Phe 1 5 10 15Val Asp Lys Thr Leu Pro Asp Gln Gly Asp Asn Asp Asn Trp Trp Thr 20 25 30Gly Trp Arg 35 945 35 PRT Artificial Sequence Core polypeptide 945Asp Trp Thr Lys Asn Ile Thr Asp Lys Ile Asp Gln Ile Ile His Asp 1 5 10 15Phe Val Asp Lys Thr Leu Pro Asp Gln Gly Asp Asn Asp Asn Trp Trp 20 25 30Thr Gly Trp 35 946 35 PRT Artificial Sequence Core polypeptide 946His Asp Trp Thr Lys Asn Ile Thr Asp Lys Ile Asp Gln Ile Ile His 1 5 10 15Asp Phe Val Asp Lys Thr Leu Pro Asp Gln Gly Asp Asn Asp Asn Trp 20 25 30Trp Thr Gly 35 947 35 PRT Artificial Sequence Core polypeptide 947Pro His Asp Trp Thr Lys Asn Ile Thr Asp Lys Ile Asp Gln Ile Ile 1 5 10 15His Asp Phe Val Asp Lys Thr Leu Pro Asp Gln Gly Asp Asn Asp Asn 20 25 30Trp Trp Thr 35 948 35 PRT Artificial Sequence Core polypeptide 948Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp Lys Ile Asp Gln Ile 1 5 10 15Ile His Asp Phe Val Asp Lys Thr Leu Pro Asp Gln Gly Asp Asn Asp 20 25 30Asn Trp Trp 35 949 35 PRT Artificial Sequence Core polypeptide 949Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp Lys Ile Asp Gln 1 5 10 15Ile Ile His Asp Phe Val Asp Lys Thr Leu Pro Asp Gln Gly Asp Asn 20 25 30Asp Asn Trp 35 950 35 PRT Artificial Sequence Core polypeptide 950Ala Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp Lys Ile Asp 1 5 10 15Gln Ile Ile His Asp Phe Val Asp Lys Thr Leu Pro Asp Gln Gly Asp 20 25 30Asn Asp Asn 35 951 35 PRT Artificial Sequence Core polypeptide 951Ala Ala Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp Lys Ile 1 5 10 15Asp Gln Ile Ile His Asp Phe Val Asp Lys Thr Leu Pro Asp Gln Gly 20 25 30Asp Asn Asp 35 952 35 PRT Artificial Sequence Core polypeptide 952Asp Ala Ala Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp Lys 1 5 10 15Ile Asp Gln Ile Ile His Asp Phe Val Asp Lys Thr Leu Pro Asp Gln 20 25 30Gly Asp Asn 35 953 35 PRT Artificial Sequence Core polypeptide 953Leu Ser Pro Thr Val Trp Leu Ser Val Ile Trp Met Met Trp Tyr Trp 1 5 10 15Gly Pro Ser Leu Tyr Ser Ile Leu Ser Pro Phe Leu Pro Leu Leu Pro 20 25 30Ile Phe Phe 35 954 45 PRT Artificial Sequence Core polypeptide 954His Asn His Thr Thr Trp Met Glu Trp Asp Arg Glu Ile Asn Asn Tyr 1 5 10 15Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu 20 25 30Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp His 35 40 45 955 53 PRT Artificial Sequence Core polypeptide 955His Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Asn Asn 1 5 10 15Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val 20 25 30Trp Gly Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr 35 40 45Leu Lys Asp Gln His 50 956 35 PRT Artificial Sequence Core polypeptide 956Val Tyr Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn Glu 1 5 10 15Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Glu Ala Asp Glu Leu Leu 20 25 30Glu Asn Val 35 957 35 PRT Artificial Sequence Core polypeptide 957Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn Glu 1 5 10 15Lys Ile Asn Gln Ser Leu Ala Tyr Ile Arg Glu Ala Asp Glu Leu Leu 20 25 30Glu Asn Val 35 958 28 PRT Artificial Sequence Core polypeptide 958Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln 1 5 10 15Ser Leu Ala Tyr Ile Arg Glu Ala Asp Glu Leu Leu 20 25 959 50 PRT Artificial Sequence Core polypeptide 959Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn 1 5 10 15Trp Phe Gly Gly Gly Gly Asp Glu Phe Asp Ala Ser Ile Ser Gln Val 20 25 30Asn Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu 35 40 45Leu Leu 50 960 45 PRT Artificial Sequence Core polypeptide 960Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe Gly Gly Gly 1 5 10 15Gly Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn 20 25 30Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu 35 40 45 961 36 PRT Artificial Sequence Core polypeptide 961Glu Gly Glu Gly Glu Gly Glu Gly Asp Glu Phe Asp Ala Ser Ile Ser 1 5 10 15Gln Val Asn Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser 20 25 30Asp Glu Leu Leu 35 962 43 PRT Artificial Sequence Core polypeptide 962Ala Ser Arg Lys Cys Arg Ala Lys Phe Lys Gln Leu Leu Gln His Tyr 1 5 10 15Arg Glu Val Ala Ala Ala Lys Ser Ser Glu Asn Asp Arg Leu Arg Leu 20 25 30Leu Leu Lys Gln Met Cys Pro Ser Leu Asp Val 35 40 963 29 PRT Artificial Sequence Core polypeptide 963Gly Asp Glu Glu Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn 1 5 10 15Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu 20 25 964 29 PRT Artificial Sequence Core polypeptide 964Gly Asp Glu Glu Asp Ala Ser Glu Ser Gln Val Asn Glu Lys Ile Asn 1 5 10 15Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu 20 25 965 29 PRT Artificial Sequence Core polypeptide 965Gly Asp Glu Glu Asp Ala Ser Glu Ser Gln Gln Asn Glu Lys Ile Asn 1 5 10 15Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu 20 25 966 29 PRT Artificial Sequence Core polypeptide 966Gly Asp Glu Glu Asp Ala Ser Glu Ser Gln Gln Asn Glu Lys Gln Asn 1 5 10 15Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu 20 25 967 29 PRT Artificial Sequence Core polypeptide 967Gly Asp Glu Glu Asp Ala Ser Glu Ser Gln Gln Asn Glu Lys Gln Asn 1 5 10 15Gln Ser Glu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu 20 25 968 30 PRT Artificial Sequence Core polypeptide 968Trp Gly Asp Glu Phe Asp Glu Ser Ile Ser Gln Val Asn Glu Lys Ile 1 5 10 15Glu Glu Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu 20 25 30 969 40 PRT Artificial Sequence Core polypeptide 969Tyr Thr Ser Leu Gly Gly Asp Glu Phe Asp Glu Ser Ile Ser Gln Val 1 5 10 15Asn Glu Lys Ile Glu Glu Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu 20 25 30Leu Leu Gly Gly Trp Asn Trp Phe 35 40 970 48 PRT Artificial Sequence Core polypeptide 970Tyr Thr Ser Leu Ile His Ser Leu Gly Gly Asp Glu Phe Asp Glu Ser 1 5 10 15Ile Ser Gln Val Asn Glu Lys Ile Glu Glu Ser Leu Ala Phe Ile Arg 20 25 30Lys Ser Asp Glu Leu Leu Gly Gly Trp Ala Ser Leu Trp Asn Trp Phe 35 40 45 971 29 PRT Artificial Sequence Core polypeptide 971Gly Asp Glu Phe Asp Glu Ser Ile Ser Gln Val Asn Glu Lys Ile Glu 1 5 10 15Glu Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu 20 25 972 29 PRT Artificial Sequence Core polypeptide 972Gly Asp Glu Glu Asp Glu Ser Ile Ser Gln Val Asn Glu Lys Ile Glu 1 5 10 15Glu Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu 20 25 973 29 PRT Artificial Sequence Core polypeptide 973Gly Asp Glu Glu Asp Glu Ser Ile Ser Gln Val Gln Glu Lys Ile Glu 1 5 10 15Glu Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu 20 25 974 29 PRT Artificial Sequence Core polypeptide 974Gly Asp Glu Glu Asp Glu Ser Ile Ser Gln Val Gln Glu Lys Ile Glu 1 5 10 15Glu Ser Leu Leu Phe Ile Arg Lys Ser Asp Glu Leu Leu 20 25 975 29 PRT Artificial Sequence Core polypeptide 975Gly Asp Glu Tyr Asp Glu Ser Ile Ser Gln Val Asn Glu Lys Ile Glu 1 5 10 15Glu Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu 20 25 976 29 PRT Artificial Sequence Core polypeptide 976Gly Asp Glu Tyr Asp Glu Ser Ile Ser Gln Val Asn Glu Lys Ile Glu 1 5 10 15Glu Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu 20 25 977 36 PRT Artificial Sequence Core polypeptide 977Tyr Thr Ser Leu Ile His Ser Leu Ile Asp Glu Gln Glu Lys Ile Glu 1 5 10 15Glu Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu Glu Leu Asp Lys 20 25 30Trp Asn Trp Phe 35 978 35 PRT Artificial Sequence Core polypeptide 978Val Tyr Pro Ser Asp Glu Tyr Asp Ala Ser Ile Ser Gln Val Asn Glu 1 5 10 15Glu Ile Asn Gln Ala Leu Ala Tyr Ile Arg Lys Ala Asp Glu Leu Leu 20 25 30Glu Asn Val 35 979 38 PRT Artificial Sequence Core polypeptide 979Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu 1 5 10 15Thr Val Trp Gly Ser Lys Gln Leu Gln Ala Arg Ile Leu Ala Val Glu 20 25 30Arg Tyr Leu Lys Asp Gln 35 980 38 PRT Artificial Sequence Core polypeptide 980Gly Gly Gly Val Tyr Pro Ser Asp Glu Tyr Asp Ala Ser Ile Ser Gln 1 5 10 15Val Asn Glu Glu Ile Asn Gln Ala Leu Ala Tyr Ile Arg Lys Ala Asp 20 25 30Glu Leu Leu Glu Asn Val 35 981 38 PRT Artificial Sequence Core polypeptide 981Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu 1 5 10 15Thr Val Trp Gly Glu Lys Gln Leu Gln Ala Arg Ile Leu Ala Val Glu 20 25 30Arg Tyr Leu Lys Asp Gln 35 982 28 PRT Artificial Sequence Core polypeptide 982Pro Thr Arg Val Asn Tyr Ile Leu Ile Ile Gly Val Leu Val Leu Ala 1 5 10 15Glu Val Thr Gly Val Arg Ala Asp Val His Leu Leu 20 25 983 35 PRT Artificial Sequence Core polypeptide 983Pro Thr Arg Val Asn Tyr Ile Leu Ile Ile Gly Val Leu Val Leu Ala 1 5 10 15Glu Val Thr Gly Val Arg Ala Asp Val His Leu Leu Glu Gln Pro Gly 20 25 30Asn Leu Trp 35 984 36 PRT Artificial Sequence Core polypeptide 984Pro Glu Lys Thr Pro Leu Leu Pro Thr Arg Val Asn Tyr Ile Leu Ile 1 5 10 15Ile Gly Val Leu Val Leu Ala Asx Glu Val Thr Gly Val Arg Ala Asp 20 25 30Val His Leu Leu 35 985 38 PRT Artificial Sequence Core polypeptide 985Gly Gly Gly Val Tyr Pro Ser Asp Glu Tyr Asp Ala Ser Ile Ser Gln 1 5 10 15Val Asn Glu Glu Ile Asn Gln Ala Leu Ala Tyr Ile Arg Lys Ala Asp 20 25 30Glu Leu Leu Glu Asn Val 35 986 38 PRT Artificial Sequence Core polypeptide 986Tyr Thr Ser Leu Ile His Ser Leu Gly Gly Asp Glu Phe Asp Glu Ser 1 5 10 15Ile Ser Gln Val Asn Glu Lys Ile Glu Glu Ser Leu Ala Phe Ile Arg 20 25 30Lys Ser Asp Glu Leu Leu 35 987 34 PRT Artificial Sequence Core polypeptide 987Tyr Thr Ser Leu Gly Gly Asp Glu Phe Asp Glu Ser Ile Ser Gln Val 1 5 10 15Asn Glu Lys Ile Glu Glu Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu 20 25 30Leu Leu 988 38 PRT Artificial Sequence Core polypeptide 988Asp Glu Phe Asp Glu Ser Ile Ser Gln Val Asn Glu Lys Ile Glu Glu 1 5 10 15Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu Gly Gly Trp Ala 20 25 30Ser Leu Trp Asn Trp Phe 35 989 34 PRT Artificial Sequence Core polypeptide 989Asp Glu Phe Asp Glu Ser Ile Ser Gln Val Asn Glu Lys Ile Glu Glu 1 5 10 15Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu Gly Gly Trp Asn 20 25 30Trp Phe 990 35 PRT Artificial Sequence Core polypeptide 990Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Ala Ser Leu Trp 20 25 30Asn Trp Phe 35 991 34 PRT Artificial Sequence Core polypeptide 991Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Ser Leu Trp Asn 20 25 30Trp Phe 992 33 PRT Artificial Sequence Core polypeptide 992Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Leu Trp Asn Trp 20 25 30Phe 993 32 PRT Artificial Sequence Core polypeptide 993Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Asn Trp Phe 20 25 30 994 47 PRT Artificial Sequence Core polypeptide 994Met Thr Trp Met Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser Leu 1 5 10 15Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu 20 25 30Gln Glu Leu Leu Glu Leu Asp Lys Ala Ser Leu Trp Asn Trp Phe 35 40 45 995 46 PRT Artificial Sequence Core polypeptide 995Met Thr Trp Met Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser Leu 1 5 10 15Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu 20 25 30Gln Glu Leu Leu Glu Leu Asp Lys Ser Leu Trp Asn Trp Phe 35 40 45 996 45 PRT Artificial Sequence Core polypeptide 996Met Thr Trp Met Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser Leu 1 5 10 15Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu 20 25 30Gln Glu Leu Leu Glu Leu Asp Lys Leu Trp Asn Trp Phe 35 40 45 997 44 PRT Artificial Sequence Core polypeptide 997Met Thr Trp Met Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser Leu 1 5 10 15Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu 20 25 30Gln Glu Leu Leu Glu Leu Asp Lys Trp Asn Trp Phe 35 40 998 46 PRT Artificial Sequence Core polypeptide 998Met Thr Trp Met Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser Leu 1 5 10 15Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu 20 25 30Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn 35 40 45 999 44 PRT Artificial Sequence Core polypeptide 999Met Thr Trp Met Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser Leu 1 5 10 15Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu 20 25 30Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 35 40 1000 8 PRT Artificial Sequence Core polypeptide 1000His Trp Ser Tyr Leu Arg Pro Gly 1 5 1001 36 PRT Artificial Sequence Core polypeptide 1001Trp Asn Trp Phe Asp Glu Phe Asp Glu Ser Ile Ser Gln Val Asn Glu 1 5 10 15Lys Ile Glu Glu Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu 20 25 30Trp Asn Trp Phe 35 1002 36 PRT Artificial Sequence Core polypeptide 1002Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Tyr Ala Ser Leu 20 25 30Tyr Asn Tyr Phe 35 1003 36 PRT Artificial Sequence Core polypeptide 1003Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Tyr Ala Tyr Leu 20 25 30Tyr Asn Tyr Phe 35 1004 29 PRT Artificial Sequence Core polypeptide 1004Asp Glu Phe Asp Glu Ser Ile Ser Gln Val Asn Glu Lys Ile Glu Glu 1 5 10 15Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu Trp 20 25 1005 31 PRT Artificial Sequence Core polypeptide 1005Gly Asp Glu Phe Asp Glu Ser Ile Ser Gln Val Asn Glu Lys Ile Glu 1 5 10 15Glu Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu Gly Trp 20 25 30 1006 29 PRT Artificial Sequence Core polypeptide 1006Gly Asp Glu Phe Asp Glu Ser Ile Ser Gln Val Asn Glu Lys Ile Glu 1 5 10 15Glu Ser Leu Ala Phe Ile Arg Glu Ser Asp Glu Leu Leu 20 25 1007 29 PRT Artificial Sequence Core polypeptide 1007Gly Asp Glu Phe Asp Glu Ser Ile Ser Gln Val Asn Glu Lys Ile Glu 1 5 10 15Glu Ser Leu Ala Phe Ile Glu Glu Ser Asp Glu Leu Leu 20 25 1008 36 PRT Artificial Sequence Core polypeptide 1008Trp Gln Glu Trp Glu Gln Lys Val Asn Tyr Leu Glu Ala Asn Ile Thr 1 5 10 15Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Asn Glu Tyr Glu 20 25 30Leu Gln Lys Leu 35 1009 36 PRT Artificial Sequence Core polypeptide 1009Trp Gln Glu Trp Glu Gln Lys Val Asp Tyr Leu Glu Ala Asn Ile Thr 1 5 10 15Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Asn Glu Tyr Glu 20 25 30Leu Gln Lys Leu 35 1010 36 PRT Artificial Sequence Core polypeptide 1010Trp Gln Glu Trp Glu Gln Lys Val Arg Trp Leu Glu Ala Asn Ile Thr 1 5 10 15Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Asn Glu Tyr Glu 20 25 30Leu Gln Lys Leu 35 1011 36 PRT Artificial Sequence Core polypeptide 1011Trp Gln Glu Trp Glu Lys Gln Val Arg Tyr Leu Glu Ala Asn Ile Thr 1 5 10 15Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Asn Glu Tyr Glu 20 25 30Leu Gln Lys Leu 35 1012 36 PRT Artificial Sequence Core polypeptide 1012Trp Gln Glu Trp Glu His Gln Val Arg Tyr Leu Glu Ala Asn Ile Thr 1 5 10 15Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Asn Glu Tyr Glu 20 25 30Leu Gln Lys Leu 35 1013 36 PRT Artificial Sequence Core polypeptide 1013Trp Gln Glu Trp Glu His Lys Val Arg Tyr Leu Glu Ala Asn Ile Thr 1 5 10 15Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Asn Glu Tyr Glu 20 25 30Leu Gln Lys Leu 35 1014 36 PRT Artificial Sequence Core polypeptide 1014Trp Gln Glu Trp Asp Arg Glu Val Arg Tyr Leu Glu Ala Asn Ile Thr 1 5 10 15Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Asn Glu Tyr Glu 20 25 30Leu Gln Lys Leu 35 1015 36 PRT Artificial Sequence Core polypeptide 1015Trp Gln Glu Trp Glu Arg Glu Val Arg Tyr Leu Glu Ala Asn Ile Thr 1 5 10 15Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Asn Glu Tyr Glu 20 25 30Leu Gln Lys Leu 35 1016 36 PRT Artificial Sequence Core polypeptide 1016Trp Gln Glu Trp Glu Arg Gln Val Arg Tyr Leu Glu Ala Asn Ile Thr 1 5 10 15Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Asn Glu Tyr Glu 20 25 30Leu Gln Lys Leu 35 1017 36 PRT Artificial Sequence Core polypeptide 1017Trp Gln Glu Trp Glu Gln Lys Val Lys Tyr Leu Glu Ala Asn Ile Thr 1 5 10 15Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Asn Glu Tyr Glu 20 25 30Leu Gln Lys Leu 35 1018 36 PRT Artificial Sequence Core polypeptide 1018Trp Gln Glu Trp Glu Gln Lys Val Arg Phe Leu Glu Ala Asn Ile Thr 1 5 10 15Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Asn Glu Tyr Glu 20 25 30Leu Gln Lys Leu 35 1019 35 PRT Artificial Sequence Core polypeptide 1019Val Asn Pro Ser Asp Glu Tyr Asp Ala Ser Ile Ser Gln Val Asn Glu 1 5 10 15Glu Ile Asn Gln Ala Leu Ala Tyr Ile Arg Lys Ala Asp Glu Leu Leu 20 25 30Glu Asn Val 35 1020 35 PRT Artificial Sequence Core polypeptide 1020Val Asn Pro Ser Asp Glu Asn Asp Ala Ser Ile Ser Gln Val Asn Glu 1 5 10 15Glu Ile Asn Gln Ala Leu Ala Tyr Ile Arg Lys Ala Asp Glu Leu Leu 20 25 30Glu Asn Val 35 1021 35 PRT Artificial Sequence Core polypeptide 1021Val Asn Pro Ser Asp Glu Tyr Asp Ala Ser Ile Ser Gln Val Asn Glu 1 5 10 15Glu Ile Asn Gln Ala Leu Ala Asn Ile Arg Lys Ala Asp Glu Leu Leu 20 25 30Glu Asn Val 35 1022 36 PRT Artificial Sequence Core polypeptide 1022Val Tyr Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn Glu 1 5 10 15Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Glu Ala Asp Glu Leu Leu 20 25 30Phe Asn Phe Phe 35 1023 36 PRT Artificial Sequence Core polypeptide 1023Val Tyr Pro Ser Asp Glu Tyr Asp Ala Ser Ile Ser Gln Val Asn Glu 1 5 10 15Glu Ile Asn Gln Ala Leu Ala Tyr Ile Arg Lys Ala Asp Glu Leu Leu 20 25 30Phe Asn Phe Phe 35 1024 36 PRT Artificial Sequence Core polypeptide 1024Tyr Thr Ser Leu Ile Thr Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln 1 5 10 15Glu Lys Asn Glu Tyr Glu Leu Gln Lys Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Asn Trp Phe 35 1025 36 PRT Artificial Sequence Core polypeptide 1025Tyr Thr Ser Leu Ile Thr Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln 1 5 10 15Glu Lys Asn Glu Tyr Glu Leu Gln Lys Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Glu Trp Phe 35 1026 36 PRT Artificial Sequence Core polypeptide 1026Tyr Thr Ser Leu Ile Thr Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln 1 5 10 15Glu Lys Asn Glu Tyr Glu Leu Gln Lys Leu Asp Glu Trp Ala Ser Leu 20 25 30Trp Glu Trp Phe 35 1027 36 PRT Artificial Sequence Core polypeptide 1027Tyr Thr Ser Leu Ile Thr Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln 1 5 10 15Glu Lys Asn Glu Tyr Glu Leu Gln Glu Leu Asp Glu Trp Ala Ser Leu 20 25 30Trp Glu Trp Phe 35 1028 36 PRT Artificial Sequence Core polypeptide 1028Tyr Thr Ser Leu Ile Thr Ala Leu Leu Glu Glu Ala Gln Ile Gln Gln 1 5 10 15Glu Lys Asn Glu Tyr Glu Leu Gln Glu Leu Asp Glu Trp Ala Ser Leu 20 25 30Trp Glu Trp Phe 35 1029 28 PRT Artificial Sequence Core polypeptide 1029Ala Ala Ala Thr Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys 1 5 10 15Asn Glu Tyr Glu Leu Gln Lys Leu Ala Ala Ala Trp 20 25 1030 36 PRT Artificial Sequence Core polypeptide 1030Trp Ala Ala Trp Glu Gln Lys Val Arg Tyr Leu Glu Ala Asn Ile Thr 1 5 10 15Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Asn Glu Tyr Glu 20 25 30Leu Gln Lys Leu 35 1031 36 PRT Artificial Sequence Core polypeptide 1031Trp Gln Glu Ala Ala Gln Lys Val Arg Tyr Leu Glu Ala Asn Ile Thr 1 5 10 15Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Asn Glu Tyr Glu 20 25 30Leu Gln Lys Leu 35 1032 36 PRT Artificial Sequence Core polypeptide 1032Trp Gln Glu Trp Ala Ala Lys Val Arg Tyr Leu Glu Ala Asn Ile Thr 1 5 10 15Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Asn Glu Tyr Glu 20 25 30Leu Gln Lys Leu 35 1033 36 PRT Artificial Sequence Core polypeptide 1033Trp Gln Glu Trp Glu Gln Lys Ala Ala Tyr Leu Glu Ala Asn Ile Thr 1 5 10 15Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Asn Glu Tyr Glu 20 25 30Leu Gln Lys Leu 35 1034 36 PRT Artificial Sequence Core polypeptide 1034Trp Gln Glu Trp Glu Gln Lys Val Ala Ala Leu Glu Ala Asn Ile Thr 1 5 10 15Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Asn Glu Tyr Glu 20 25 30Leu Gln Lys Leu 35 1035 29 PRT Artificial Sequence Core polypeptide 1035Gly Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn 1 5 10 15Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Thr 20 25 1036 29 PRT Artificial Sequence Core polypeptide 1036Gly Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn 1 5 10 15Gln Ser Leu Ala Phe Thr Arg Lys Ser Asp Glu Leu Thr 20 25 1037 29 PRT Artificial Sequence Core polypeptide 1037Gly Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Thr Asn 1 5 10 15Gln Ser Leu Ala Phe Thr Arg Lys Ser Asp Glu Leu Thr 20 25 1038 29 PRT Artificial Sequence Core polypeptide 1038Gly Asp Glu Phe Asp Ala Ser Ile Ser Gln Thr Asn Glu Lys Thr Asn 1 5 10 15Gln Ser Leu Ala Phe Thr Arg Lys Ser Asp Glu Leu Thr 20 25 1039 29 PRT Artificial Sequence Core polypeptide 1039Gly Asp Glu Phe Asp Ala Ser Thr Ser Gln Thr Asn Glu Lys Thr Asn 1 5 10 15Gln Ser Leu Ala Phe Thr Arg Lys Ser Asp Glu Leu Thr 20 25 1040 29 PRT Artificial Sequence Core polypeptide 1040Gly Asp Glu Tyr Asp Ala Ser Thr Ser Gln Thr Asn Glu Lys Thr Asn 1 5 10 15Gln Ser Leu Ala Phe Thr Arg Lys Ser Asp Glu Leu Thr 20 25 1041 29 PRT Artificial Sequence Core polypeptide 1041Gly Asp Glu Phe Asp Glu Glu Ile Ser Gln Val Asn Glu Lys Ile Glu 1 5 10 15Glu Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu 20 25 1042 29 PRT Artificial Sequence Core polypeptide 1042Gly Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn 1 5 10 15Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Ala 20 25 1043 29 PRT Artificial Sequence Core polypeptide 1043Gly Asp Glu Phe Asp Ala Ser Ala Ser Gln Ala Asn Glu Lys Ala Asn 1 5 10 15Gln Ser Leu Ala Phe Ala Arg Lys Ser Asp Glu Leu Ala 20 25 1044 29 PRT Artificial Sequence Core polypeptide 1044Gly Asp Glu Phe Asp Glu Ser Ile Ser Gln Val Asn Glu Lys Ile Glu 1 5 10 15Glu Ser Leu Ala Phe Thr Arg Lys Ser Asp Glu Leu Leu 20 25 1045 29 PRT Artificial Sequence Core polypeptide 1045Gly Asp Glu Phe Asp Glu Ser Ile Ser Gln Val Asn Glu Lys Thr Glu 1 5 10 15Glu Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu 20 25 1046 29 PRT Artificial Sequence Core polypeptide 1046Gly Asp Glu Phe Asp Glu Ser Ile Ser Gln Thr Asn Glu Lys Ile Glu 1 5 10 15Glu Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu 20 25 1047 29 PRT Artificial Sequence Core polypeptide 1047Gly Asp Glu Phe Asp Glu Ser Thr Ser Gln Val Asn Glu Lys Ile Glu 1 5 10 15Glu Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu 20 25 1048 36 PRT Artificial Sequence Core polypeptide 1048Trp Asn Trp Phe Asp Glu Phe Asp Glu Ser Thr Ser Gln Val Asn Glu 1 5 10 15Lys Ile Glu Glu Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu 20 25 30Trp Asn Trp Phe 35 1049 36 PRT Artificial Sequence Core polypeptide 1049Trp Asn Trp Phe Asp Glu Phe Asp Glu Ser Thr Ser Gln Thr Asn Glu 1 5 10 15Lys Ile Glu Glu Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu 20 25 30Trp Asn Trp Phe 35 1050 36 PRT Artificial Sequence Core polypeptide 1050Trp Asn Trp Phe Asp Glu Phe Asp Glu Ser Thr Ser Gln Thr Asn Glu 1 5 10 15Lys Thr Glu Glu Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu 20 25 30Trp Asn Trp Phe 35 1051 36 PRT Artificial Sequence Core polypeptide 1051Tyr Thr Asn Leu Ile Tyr Thr Leu Leu Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Ser Trp Phe 35 1052 46 PRT Artificial Sequence Core polypeptide 1052Trp Gln Glu Trp Glu Gln Lys Val Arg Tyr Leu Glu Ala Asn Ile Thr 1 5 10 15Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Asn Glu Tyr Glu 20 25 30Leu Gln Lys Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe 35 40 45 1053 50 PRT Artificial Sequence Core polypeptide 1053Asn Asn Met Thr Trp Gln Glu Trp Glu Gln Lys Val Arg Tyr Leu Glu 1 5 10 15Ala Asn Ile Thr Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys 20 25 30Asn Glu Tyr Glu Leu Gln Lys Leu Asp Lys Trp Ala Ser Leu Trp Asn 35 40 45Trp Phe 50 1054 16 PRT Artificial Sequence Core polypeptide 1054Trp Asn Trp Phe Ile Glu Glu Ser Asp Glu Leu Leu Trp Asn Trp Phe 1 5 10 15 1055 11 PRT Artificial Sequence Core polypeptide 1055Gly Phe Ile Glu Glu Ser Asp Glu Leu Leu Trp 1 5 10 1056 11 PRT Artificial Sequence Core polypeptide 1056Trp Phe Ile Glu Glu Ser Asp Glu Leu Leu Trp 1 5 10 1057 17 PRT Artificial Sequence Core polypeptide 1057Gly Phe Asn Phe Phe Ile Glu Glu Ser Asp Glu Leu Leu Phe Asn Phe 1 5 10 15Phe 1058 7 PRT Artificial Sequence Core polypeptide 1058Gly Glu Ser Asp Glu Leu Trp 1 5 1059 39 PRT Artificial Sequence Core polypeptide 1059Trp Asn Trp Phe Gly Asp Glu Phe Asp Glu Ser Ile Ser Gln Val Gln 1 5 10 15Glu Glu Ile Glu Glu Ser Leu Ala Phe Ile Glu Glu Ser Asp Glu Leu 20 25 30Leu Gly Gly Trp Asn Trp Phe 35 1060 48 PRT Artificial Sequence Core polypeptide 1060Tyr Thr Ser Leu Ile His Ser Leu Gly Gly Asp Glu Phe Asp Glu Ser 1 5 10 15Ile Ser Gln Val Asn Glu Glu Ile Glu Glu Ser Leu Ala Phe Ile Glu 20 25 30Glu Ser Asp Glu Leu Leu Gly Gly Trp Ala Ser Leu Trp Asn Trp Phe 35 40 45 1061 29 PRT Artificial Sequence Core polypeptide 1061Gly Asp Glu Phe Asp Glu Ser Ile Ser Gln Val Gln Glu Glu Ile Glu 1 5 10 15Glu Ser Leu Ala Phe Ile Glu Glu Ser Asp Glu Leu Leu 20 25 1062 53 PRT Artificial Sequence Core polypeptide 1062His Gln Ala Arg Gln Leu Leu Ser Ser Ile Met Gln Gln Gln Asn Asn 1 5 10 15Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val 20 25 30Trp Gly Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr 35 40 45Leu Lys Asp Gln His 50 1063 25 PRT Artificial Sequence Core polypeptide 1063Cys Pro Lys Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr Gly Met 1 5 10 15Arg Asn Val Pro Glu Lys Gln Thr Arg 20 25 1064 30 PRT Artificial Sequence Core polypeptide 1064Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly 1 5 10 15Met Ile Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ser Cys 20 25 30 1065 7 PRT Artificial Sequence Core polypeptide 1065Leu Asn Phe Leu Gly Gly Thr 1 5 1066 14 PRT Artificial Sequence Core polypeptide 1066Leu Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly Gly Thr 1 5 10 1067 21 PRT Artificial Sequence Core polypeptide 1067Ile Leu Thr Ile Pro Gln Ser Leu Asp Ser Trp Trp Thr Ser Leu Asn 1 5 10 15Phe Leu Gly Gly Thr 20 1068 28 PRT Artificial Sequence Core polypeptide 1068Gly Phe Phe Leu Leu Thr Arg Ile Leu Thr Ile Pro Gln Ser Leu Asp 1 5 10 15Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly Gly Thr 20 25 1069 39 PRT Artificial Sequence Core polypeptide 1069Trp Gln Glu Trp Glu Gln Lys Ile Thr Ala Leu Leu Glu Gln Ala Gln 1 5 10 15Ile Gln Gln Glu Lys Asn Glu Tyr Glu Leu Gln Lys Leu Asp Lys Trp 20 25 30Ala Ser Leu Trp Asn Trp Phe 35 1070 36 PRT Artificial Sequence Core polypeptide 1070Trp Asn Trp Phe Ile Thr Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln 1 5 10 15Glu Lys Asn Glu Tyr Glu Leu Gln Lys Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Asn Trp Phe 35 1071 39 PRT Artificial Sequence Core polypeptide 1071Trp Gln Glu Trp Glu Gln Lys Ile Thr Ala Leu Leu Glu Gln Ala Gln 1 5 10 15Ile Gln Gln Glu Lys Asn Glu Tyr Glu Leu Gln Lys Leu Asp Lys Trp 20 25 30Ala Ser Leu Trp Glu Trp Phe 35 1072 36 PRT Artificial Sequence Core polypeptide 1072Trp Gln Glu Trp Glu Gln Lys Val Arg Tyr Leu Glu Ala Asn Ile Thr 1 5 10 15Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Ile Glu Tyr Glu 20 25 30Leu Gln Lys Leu 35 1073 36 PRT Artificial Sequence Core polypeptide 1073Trp Gln Glu Trp Glu Gln Lys Val Arg Tyr Leu Glu Ala Gln Ile Thr 1 5 10 15Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Ile Glu Tyr Glu 20 25 30Leu Gln Lys Leu 35 1074 35 PRT Artificial Sequence Core polypeptide 1074Lys Glu Asn Lys Ala Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 1 5 10 15Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 20 25 30Met Gln Ser 35 1075 35 PRT Artificial Sequence Core polypeptide 1075Asn Ile Lys Glu Asn Lys Ala Asn Gly Thr Asp Ala Lys Val Lys Leu 1 5 10 15Ile Lys Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln 20 25 30Leu Leu Met 35 1076 36 PRT Artificial Sequence Core polypeptide 1076Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Asn Trp Phe 35 1077 37 PRT Artificial Sequence Core polypeptide 1077Gly Trp Asn Trp Phe Asp Glu Phe Asp Glu Ser Ile Ser Gln Val Gln 1 5 10 15Glu Glu Ile Glu Glu Ser Leu Ala Phe Ile Glu Glu Ser Asp Glu Leu 20 25 30Leu Trp Asn Trp Phe 35 1078 38 PRT Artificial Sequence Core polypeptide 1078Trp Asn Trp Phe Gly Asp Glu Phe Asp Glu Ser Ile Ser Gln Val Asn 1 5 10 15Glu Lys Ile Glu Glu Ser Leu Ala Phe Ile Glu Glu Ser Asp Glu Leu 20 25 30Leu Gly Trp Asn Trp Phe 35 1079 38 PRT Artificial Sequence Core polypeptide 1079Trp Asn Trp Phe Gly Asp Glu Phe Asp Glu Ser Ile Ser Gln Val Asn 1 5 10 15Glu Lys Ile Glu Glu Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu 20 25 30Leu Gly Trp Asn Trp Phe 35 1080 36 PRT Artificial Sequence Core polypeptide 1080Trp Asn Trp Phe Asp Glu Phe Asp Glu Ser Ile Ser Gln Val Asn Glu 1 5 10 15Lys Ile Glu Glu Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu 20 25 30Trp Asn Trp Phe 35 1081 36 PRT Artificial Sequence Core polypeptide 1081Trp Asn Trp Phe Asp Glu Phe Asp Glu Ser Ile Ser Gln Val Asn Glu 1 5 10 15Lys Ile Glu Glu Ser Leu Ala Phe Ile Glu Glu Ser Asp Glu Leu Leu 20 25 30Trp Asn Trp Phe 35 1082 21 PRT Artificial Sequence Core polypeptide 1082Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu 1 5 10 15Leu Asp Lys Trp Ala 20 1083 21 PRT Artificial Sequence Core polypeptide 1083Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu 1 5 10 15Leu Asp Lys Trp Ala 20 1084 36 PRT Artificial Sequence Core polypeptide 1084Cys Gly Thr Thr Asp Arg Ser Gly Ala Pro Thr Tyr Ser Trp Gly Ala 1 5 10 15Asn Asp Thr Asp Val Phe Val Leu Asn Asn Thr Arg Pro Pro Leu Gly 20 25 30Asn Trp Phe Gly 35 1085 28 PRT Artificial Sequence Core polypeptide 1085Gly Val Glu His Arg Leu Glu Ala Asn Trp Thr Arg Gly Glu Arg Ala 1 5 10 15Asp Leu Glu Asp Arg Asp Arg Ser Glu Leu Ser Pro 20 25 1086 27 PRT Artificial Sequence Core polypeptide 1086Cys Val Arg Glu Gly Asn Ala Ser Arg Ala Trp Val Ala Val Thr Pro 1 5 10 15Thr Val Ala Thr Arg Asp Gly Lys Leu Pro Thr 20 25 1087 20 PRT Artificial Sequence Core polypeptide 1087Cys Phe Ser Pro Arg His His Trp Thr Thr Gln Asp Ala Asn Ala Ser 1 5 10 15Ile Tyr Pro Gly 20 1088 33 PRT Artificial Sequence Core polypeptide 1088Leu Gln His Tyr Arg Glu Val Ala Ala Ala Lys Ser Ser Glu Asn Asp 1 5 10 15Arg Leu Arg Leu Leu Leu Lys Gln Met Cys Pro Ser Leu Asp Val Asp 20 25 30Ser 1089 46 PRT Artificial Sequence Core polypeptide 1089Trp Gln Glu Trp Asp Arg Glu Ile Ser Asn Tyr Thr Ser Leu Ile Thr 1 5 10 15Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Asn Glu Tyr Glu 20 25 30Leu Gln Lys Leu Asp Glu Trp Ala Ser Leu Trp Glu Trp Phe 35 40 45 1090 48 PRT Artificial Sequence Core polypeptide 1090Cys Trp Gln Glu Trp Asp Arg Glu Ile Ser Asn Tyr Thr Ser Leu Ile 1 5 10 15Thr Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Asn Glu Tyr 20 25 30Glu Leu Gln Lys Leu Asp Glu Trp Ala Ser Leu Trp Glu Trp Phe Cys 35 40 45 1091 42 PRT Artificial Sequence Core polypeptide 1091Trp Gln Glu Trp Asp Arg Glu Ile Ser Asn Tyr Thr Ser Leu Ile Thr 1 5 10 15Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Asn Glu Tyr Glu 20 25 30Leu Gln Lys Leu Asp Glu Trp Glu Trp Phe 35 40 1092 44 PRT Artificial Sequence Core polypeptide 1092Cys Trp Gln Glu Trp Asp Arg Glu Ile Ser Asn Tyr Thr Ser Leu Ile 1 5 10 15Thr Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Asn Glu Tyr 20 25 30Glu Leu Gln Lys Leu Asp Glu Trp Glu Trp Phe Cys 35 40 1093 26 PRT Artificial Sequence Core polypeptide 1093Gly Gln Asn Ser Gln Ser Pro Thr Ser Asn His Ser Pro Thr Ser Ala 1 5 10 15Pro Pro Thr Ala Pro Gly Tyr Arg Trp Ala 20 25 1094 27 PRT Artificial Sequence Core polypeptide 1094Pro Gly Ser Ser Thr Thr Ser Thr Gly Pro Ala Arg Thr Ala Leu Thr 1 5 10 15Thr Ala Gln Gly Thr Ser Leu Tyr Pro Ser Ala 20 25 1095 39 PRT Artificial Sequence Core polypeptide 1095Pro Gly Ser Ser Thr Thr Ser Thr Gly Pro Ala Arg Thr Ala Leu Thr 1 5 10 15Thr Ala Gln Gly Thr Ser Leu Tyr Pro Ser Ala Ala Ala Thr Lys Pro 20 25 30Ser Asp Gly Asn Ala Thr Ala 35 1096 16 PRT Artificial Sequence Core polypeptide 1096Gln Lys Gln Glu Pro Ile Asp Lys Glu Leu Tyr Pro Leu Thr Ser Leu 1 5 10 15 1097 39 PRT Artificial Sequence Core polypeptide 1097Trp Gln Glu Trp Asp Arg Glu Ile Thr Ala Leu Leu Glu Gln Ala Gln 1 5 10 15Ile Gln Gln Glu Lys Asn Glu Tyr Glu Leu Gln Lys Leu Asp Lys Trp 20 25 30Ala Ser Leu Trp Asn Trp Phe 35 1098 39 PRT Artificial Sequence Core polypeptide 1098Trp Gln Glu Trp Asp Arg Glu Ile Thr Ala Leu Leu Glu Gln Ala Gln 1 5 10 15Ile Gln Gln Glu Lys Asn Glu Tyr Glu Leu Gln Lys Leu Asp Glu Trp 20 25 30Ala Ser Leu Trp Glu Trp Phe 35 1099 35 PRT Artificial Sequence Core polypeptide 1099Trp Gln Glu Trp Asp Arg Glu Ile Thr Ala Leu Leu Glu Gln Ala Gln 1 5 10 15Ile Gln Gln Glu Lys Asn Glu Tyr Glu Leu Gln Lys Leu Asp Glu Trp 20 25 30Glu Trp Phe 35 1100 35 PRT Artificial Sequence Core polypeptide 1100Trp Gln Glu Trp Glu Arg Glu Ile Thr Ala Leu Leu Glu Gln Ala Gln 1 5 10 15Ile Gln Gln Glu Lys Ile Glu Tyr Glu Leu Gln Lys Leu Ile Glu Trp 20 25 30Glu Trp Phe 35 1101 35 PRT Artificial Sequence Core polypeptide 1101Trp Gln Glu Trp Glu Arg Glu Ile Thr Ala Leu Leu Glu Gln Ala Gln 1 5 10 15Ile Gln Gln Glu Lys Asn Glu Tyr Glu Leu Gln Lys Leu Ile Glu Trp 20 25 30Glu Trp Phe 35 1102 35 PRT Artificial Sequence Core polypeptide 1102Trp Gln Glu Trp Glu Arg Glu Ile Thr Ala Leu Leu Glu Gln Ala Gln 1 5 10 15Ile Gln Gln Glu Lys Ile Glu Tyr Glu Leu Gln Lys Leu Asp Glu Trp 20 25 30Glu Trp Phe 35 1103 33 PRT Artificial Sequence Core polypeptide 1103Trp Gln Glu Trp Glu Ile Thr Ala Leu Leu Glu Gln Ala Gln Ile Gln 1 5 10 15Gln Glu Lys Asn Glu Tyr Glu Leu Gln Lys Leu Asp Glu Trp Glu Trp 20 25 30Phe 1104 33 PRT Artificial Sequence Core polypeptide 1104Trp Gln Glu Trp Glu Ile Thr Ala Leu Leu Glu Gln Ala Gln Ile Gln 1 5 10 15Gln Glu Lys Asn Glu Tyr Glu Leu Gln Lys Leu Ile Glu Trp Glu Trp 20 25 30Phe 1105 33 PRT Artificial Sequence Core polypeptide 1105Trp Gln Glu Trp Glu Ile Thr Ala Leu Leu Glu Gln Ala Gln Ile Gln 1 5 10 15Gln Glu Lys Ile Glu Tyr Glu Leu Gln Lys Leu Asp Glu Trp Glu Trp 20 25 30Phe 1106 33 PRT Artificial Sequence Core polypeptide 1106Trp Gln Glu Trp Glu Ile Thr Ala Leu Leu Glu Gln Ala Gln Ile Gln 1 5 10 15Gln Glu Lys Ile Glu Tyr Glu Leu Gln Lys Leu Ile Glu Trp Glu Trp 20 25 30Phe 1107 39 PRT Artificial Sequence Core polypeptide 1107Trp Gln Glu Trp Asp Arg Glu Ile Asp Glu Tyr Asp Ala Ser Ile Ser 1 5 10 15Gln Val Asn Glu Lys Ile Asn Gln Ala Leu Ala Tyr Ile Arg Glu Ala 20 25 30Asp Glu Leu Trp Glu Trp Phe 35 1108 39 PRT Artificial Sequence Core polypeptide 1108Trp Gln Glu Trp Glu Arg Glu Ile Asp Glu Tyr Asp Ala Ser Ile Ser 1 5 10 15Gln Val Asn Glu Lys Ile Asn Gln Ala Leu Ala Tyr Ile Arg Glu Ala 20 25 30Asp Glu Leu Trp Glu Trp Phe 35 1109 37 PRT Artificial Sequence Core polypeptide 1109Trp Gln Glu Trp Glu Ile Asp Glu Tyr Asp Ala Ser Ile Ser Gln Val 1 5 10 15Asn Glu Lys Ile Asn Gln Ala Leu Ala Tyr Ile Arg Glu Ala Asp Glu 20 25 30Leu Trp Glu Trp Phe 35 1110 39 PRT Artificial Sequence Core polypeptide 1110Trp Gln Glu Trp Asp Arg Glu Ile Asp Glu Tyr Asp Ala Ser Ile Ser 1 5 10 15Gln Val Asn Glu Glu Ile Asn Gln Ala Leu Ala Tyr Ile Arg Glu Ala 20 25 30Asp Glu Leu Trp Glu Trp Phe 35 1111 39 PRT Artificial Sequence Core polypeptide 1111Trp Gln Glu Trp Glu Arg Glu Ile Asp Glu Tyr Asp Ala Ser Ile Ser 1 5 10 15Gln Val Asn Glu Glu Ile Asn Gln Ala Leu Ala Tyr Ile Arg Glu Ala 20 25 30Asp Glu Leu Trp Glu Trp Phe 35 1112 37 PRT Artificial Sequence Core polypeptide 1112Trp Gln Glu Trp Glu Ile Asp Glu Tyr Asp Ala Ser Ile Ser Gln Val 1 5 10 15Asn Glu Glu Ile Asn Gln Ala Leu Ala Tyr Ile Arg Glu Ala Asp Glu 20 25 30Leu Trp Glu Trp Phe 35 1113 35 PRT Artificial Sequence Core polypeptide 1113Trp Gln Glu Trp Asp Glu Tyr Asp Ala Ser Ile Ser Gln Val Asn Glu 1 5 10 15Lys Ile Asn Gln Ala Leu Ala Tyr Ile Arg Glu Ala Asp Glu Leu Trp 20 25 30Glu Trp Phe 35 1114 35 PRT Artificial Sequence Core polypeptide 1114Trp Gln Glu Trp Asp Glu Tyr Asp Ala Ser Ile Ser Gln Val Asn Glu 1 5 10 15Glu Ile Asn Gln Ala Leu Ala Tyr Ile Arg Glu Ala Asp Glu Leu Trp 20 25 30Glu Trp Phe 35 1115 35 PRT Artificial Sequence Core polypeptide 1115Trp Gln Glu Trp Glu Gln Lys Ile Thr Ala Leu Leu Glu Gln Ala Gln 1 5 10 15Ile Gln Gln Glu Lys Ile Glu Tyr Glu Leu Gln Lys Leu Ile Glu Trp 20 25 30Glu Trp Phe 35 1116 39 PRT Artificial Sequence Core polypeptide 1116Trp Gln Glu Trp Glu Gln Lys Ile Thr Ala Leu Leu Glu Gln Ala Gln 1 5 10 15Ile Gln Gln Glu Lys Ile Glu Tyr Glu Leu Gln Lys Leu Ile Glu Trp 20 25 30Ala Ser Leu Trp Glu Trp Phe 35 1117 37 PRT Artificial Sequence Core polypeptide 1117Trp Gln Glu Trp Glu Ile Thr Ala Leu Leu Glu Gln Ala Gln Ile Gln 1 5 10 15Gln Glu Lys Ile Glu Tyr Glu Leu Gln Lys Leu Ile Glu Trp Ala Ser 20 25 30Leu Trp Glu Trp Phe 35 1118 44 PRT Artificial Sequence Core polypeptide 1118Asn His Thr Thr Trp Met Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr 1 5 10 15Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys 20 25 30Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp His 35 40 1119 52 PRT Artificial Sequence Core polypeptide 1119Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu 1 5 10 15Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp 20 25 30Gly Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr Leu 35 40 45Lys Asp Gln His 50 1120 40 PRT Artificial Sequence Core polypeptide 1120Trp Val Tyr Pro Ser Asp Glu Tyr Asp Ala Ser Ile Ser Gln Val Asn 1 5 10 15Glu Glu Ile Asn Gln Ala Leu Ala Tyr Ile Arg Lys Ala Asp Glu Leu 20 25 30Leu Glu Asn Val Trp Asn Trp Phe 35 40 1121 36 PRT Artificial Sequence Core polypeptide 1121Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Asn Trp Phe 35 1122 35 PRT Artificial Sequence Core polypeptide 1122Trp Gln Glu Trp Asp Glu Tyr Asp Ala Ser Ile Ser Gln Val Asn Glu 1 5 10 15Lys Ile Asn Gln Ala Leu Ala Tyr Ile Arg Glu Ala Asp Glu Leu Trp 20 25 30Ala Trp Phe 35 1123 35 PRT Artificial Sequence Core polypeptide 1123Trp Gln Ala Trp Asp Glu Tyr Asp Ala Ser Ile Ser Gln Val Asn Glu 1 5 10 15Lys Ile Asn Gln Ala Leu Ala Tyr Ile Arg Glu Ala Asp Glu Leu Trp 20 25 30Ala Trp Phe 35 1124 35 PRT Artificial Sequence Core polypeptide 1124Trp Gln Ala Trp Asp Glu Tyr Asp Ala Ser Ile Ser Gln Val Asn Glu 1 5 10 15Lys Ile Asn Gln Ala Leu Ala Tyr Ile Arg Glu Ala Asp Glu Leu Trp 20 25 30Glu Trp Phe 35 1125 35 PRT Artificial Sequence Core polypeptide 1125Tyr Asp Pro Leu Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser 1 5 10 15Gln Val Asn Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser 20 25 30Asp Glu Leu 35 1126 28 PRT Artificial Sequence Core polypeptide 1126Tyr Asp Pro Leu Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser 1 5 10 15Gln Val Asn Glu Lys Ile Asn Gln Ser Leu Ala Phe 20 25 1127 29 PRT Artificial Sequence Core polypeptide 1127Gln Val Asn Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser 1 5 10 15Asp Glu Leu Leu His Asn Val Asn Ala Gly Lys Ser Thr 20 25 1128 8 PRT Artificial Sequence Core polypeptide 1128Trp Met Glu Trp Asp Arg Glu Ile 1 5 1129 8 PRT Artificial Sequence Core polypeptide 1129Trp Gln Glu Trp Glu Gln Lys Ile 1 5 1130 39 PRT Artificial Sequence Core polypeptide 1130Trp Gln Glu Trp Glu Gln Lys Ile Thr Ala Leu Leu Glu Gln Ala Gln 1 5 10 15Ile Gln Gln Glu Lys Ile Glu Tyr Glu Leu Gln Lys Leu Ile Lys Trp 20 25 30Ala Ser Leu Trp Glu Trp Phe 35 1131 39 PRT Artificial Sequence Core polypeptide 1131Trp Gln Glu Trp Glu Gln Lys Ile Thr Ala Leu Leu Glu Gln Ala Gln 1 5 10 15Ile Gln Gln Glu Lys Ile Glu Tyr Glu Leu Gln Lys Leu Ile Glu Trp 20 25 30Ala Ser Leu Trp Glu Trp Phe 35 1132 42 PRT Artificial Sequence Core polypeptide 1132Trp Gln Glu Trp Glu Arg Glu Ile Ser Ala Tyr Thr Ser Leu Ile Thr 1 5 10 15Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Ile Glu Tyr Glu 20 25 30Leu Gln Lys Leu Ile Glu Trp Glu Trp Phe 35 40 1133 40 PRT Artificial Sequence Core polypeptide 1133Trp Gln Glu Trp Glu Arg Glu Ile Ser Ala Tyr Thr Ser Leu Ile Thr 1 5 10 15Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Ile Glu Tyr Glu 20 25 30Leu Gln Lys Glu Trp Glu Trp Phe 35 40 1134 39 PRT Artificial Sequence Core polypeptide 1134Trp Gln Glu Trp Glu Arg Glu Ile Ser Ala Tyr Thr Ser Leu Ile Thr 1 5 10 15Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Ile Glu Tyr Glu 20 25 30Leu Gln Lys Glu Trp Glu Trp 35 1135 41 PRT Artificial Sequence Core polypeptide 1135Trp Gln Glu Trp Glu Arg Glu Ile Ser Ala Tyr Thr Ser Leu Ile Thr 1 5 10 15Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Ile Glu Tyr Glu 20 25 30Leu Gln Lys Leu Ile Glu Trp Glu Trp 35 40 1136 36 PRT Artificial Sequence Core polypeptide 1136Phe Asn Leu Ser Asp His Ser Glu Ser Ile Gln Lys Lys Phe Gln Leu 1 5 10 15Met Lys Lys His Val Asn Lys Ile Gly Val Asp Ser Asp Pro Ile Gly 20 25 30Ser Trp Leu Arg 35 1137 35 PRT Artificial Sequence Core polypeptide 1137Asp His Ser Glu Ser Ile Gln Lys Lys Phe Gln Leu Met Lys Lys His 1 5 10 15Val Asn Lys Ile Gly Val Asp Ser Asp Pro Ile Gly Ser Trp Leu Arg 20 25 30Gly Ile Phe 35 1138 40 PRT Artificial Sequence Core polypeptide 1138Trp Ser Val Lys Gln Ala Asn Leu Thr Thr Ser Leu Leu Gly Asp Leu 1 5 10 15Leu Asp Asp Val Thr Ser Ile Arg His Ala Val Leu Gln Asn Arg Ala 20 25 30Trp Met Glu Trp Asp Arg Glu Ile 35 40 1139 18 PRT Artificial Sequence Core polypeptide 1139Asn Asn Met Thr Trp Met Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr 1 5 10 15Ser Leu 1140 36 PRT Artificial Sequence Core polypeptide 1140Gly Ala Ala Ser Leu Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser 1 5 10 15Gly Ile Val Gln Gln Gln Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln 20 25 30Gln His Leu Leu 35 1141 36 PRT Artificial Sequence Core polypeptide 1141Ala Ser Leu Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile 1 5 10 15Val Gln Gln Gln Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His 20 25 30Leu Leu Gln Leu 35 1142 34 PRT Artificial Sequence Core polypeptide 1142Val Ser Val Gly Asn Thr Leu Tyr Tyr Val Asn Lys Gln Glu Gly Lys 1 5 10 15Ser Leu Tyr Val Lys Gly Glu Pro Ile Ile Asn Phe Tyr Asp Pro Leu 20 25 30Val Phe 1143 10 PRT Artificial Sequence Core polypeptide 1143Gln His Trp Ser Tyr Gly Leu Arg Pro Gly 1 5 10 1144 26 PRT Artificial Sequence Core polypeptide 1144Trp Gln Glu Trp Glu Gln Lys Ile Gln His Trp Ser Tyr Gly Leu Arg 1 5 10 15Pro Gly Trp Ala Ser Leu Trp Glu Trp Phe 20 25 1145 22 PRT Artificial Sequence Core polypeptide 1145Trp Gln Glu Trp Glu Gln Lys Ile Gln His Trp Ser Tyr Gly Leu Arg 1 5 10 15Pro Gly Trp Glu Trp Phe 20 1146 18 PRT Artificial Sequence Core polypeptide 1146Trp Asn Trp Phe Gln His Trp Ser Tyr Gly Leu Arg Pro Gly Trp Asn 1 5 10 15Trp Phe 1147 18 PRT Artificial Sequence Core polypeptide 1147Phe Asn Phe Phe Gln His Trp Ser Tyr Gly Leu Arg Pro Gly Phe Asn 1 5 10 15Phe Phe 1148 18 PRT Artificial Sequence Core polypeptide 1148Gly Ala Gly Ala Gln His Trp Ser Tyr Gly Leu Arg Pro Gly Ala Gly 1 5 10 15Ala Gly 1149 39 PRT Artificial Sequence Core polypeptide 1149Trp Gln Glu Trp Glu Gln Lys Ile Thr Ala Leu Leu Glu Gln Ala Gln 1 5 10 15Ile Gln Gln Glu Lys Ile Glu Tyr Glu Leu Gln Lys Leu Ala Lys Trp 20 25 30Ala Ser Leu Trp Glu Trp Phe 35 1150 39 PRT Artificial Sequence Core polypeptide 1150Trp Gln Glu Trp Glu Gln Lys Ile Thr Ala Leu Leu Glu Gln Ala Gln 1 5 10 15Ile Gln Gln Glu Lys Ile Glu Tyr Glu Leu Gln Lys Leu Ala Glu Trp 20 25 30Ala Ser Leu Trp Glu Trp Phe 35 1151 39 PRT Artificial Sequence Core polypeptide 1151Trp Gln Glu Trp Glu Gln Lys Ile Thr Ala Leu Leu Glu Gln Ala Gln 1 5 10 15Ile Gln Gln Glu Lys Ala Glu Tyr Glu Leu Gln Lys Leu Ala Glu Trp 20 25 30Ala Ser Leu Trp Glu Trp Phe 35 1152 39 PRT Artificial Sequence Core polypeptide 1152Trp Gln Glu Trp Glu Gln Lys Ile Thr Ala Leu Leu Glu Gln Ala Gln 1 5 10 15Ile Gln Gln Glu Lys Ala Glu Tyr Glu Leu Gln Lys Leu Ala Glu Trp 20 25 30Ala Ser Leu Trp Ala Trp Phe 35 1153 39 PRT Artificial Sequence Core polypeptide 1153Trp Gln Glu Trp Glu Gln Lys Ile Thr Ala Leu Leu Glu Gln Ala Gln 1 5 10 15Ile Gln Gln Glu Lys Ala Glu Tyr Glu Leu Gln Lys Leu Ala Lys Trp 20 25 30Ala Ser Leu Trp Ala Trp Phe 35 1154 36 PRT Artificial Sequence Core polypeptide 1154Thr Asn Lys Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr 1 5 10 15Ser Lys Val Leu Asp Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu Pro 20 25 30Ile Val Asn Lys 35 1155 36 PRT Artificial Sequence Core polypeptide 1155Lys Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Ser Lys 1 5 10 15Val Leu Asp Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu Pro Ile Val 20 25 30Asn Lys Gln Ser 35 1156 35 PRT Artificial Sequence Core polypeptide 1156Trp Gln Glu Trp Glu Gln Lys Ile Thr Ala Leu Leu Glu Gln Ala Gln 1 5 10 15Ile Gln Gln Glu Lys Asn Glu Tyr Glu Leu Gln Lys Leu Ile Glu Trp 20 25 30Glu Trp Phe 35 1157 35 PRT Artificial Sequence Core polypeptide 1157Trp Gln Glu Trp Glu Gln Lys Ile Thr Ala Leu Leu Glu Gln Ala Gln 1 5 10 15Ile Gln Gln Glu Lys Gly Glu Tyr Glu Leu Gln Lys Leu Ile Glu Trp 20 25 30Glu Trp Phe 35 1158 35 PRT Artificial Sequence Core polypeptide 1158Trp Gln Glu Trp Glu Gln Lys Ile Thr Ala Leu Leu Glu Gln Ala Gln 1 5 10 15Ile Gln Gln Glu Lys Ile Glu Tyr Glu Leu Gln Lys Leu Asp Lys Trp 20 25 30Glu Trp Phe 35 1159 28 PRT Artificial Sequence Core polypeptide 1159Tyr Asp Pro Leu Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser 1 5 10 15Gln Val Asn Glu Lys Ile Asn Gln Ser Leu Ala Phe 20 25 1160 35 PRT Artificial Sequence Core polypeptide 1160Val Tyr Pro Ser Asp Glu Tyr Asp Ala Ser Ile Ser Gln Val Asn Glu 1 5 10 15Glu Ile Asn Gln Ala Leu Ala Tyr Ile Arg Lys Ala Asp Glu Leu Leu 20 25 30Glu Asn Val 35 1161 36 PRT Artificial Sequence Core polypeptide 1161Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Asn Trp Phe 35 1162 36 PRT Artificial Sequence Core polypeptide 1162Ser Gly Ile Val Gln Gln Gln Asn Asn Leu Leu Arg Ala Ile Glu Ala 1 5 10 15Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln 20 25 30Ala Arg Ile Leu 35 1163 41 PRT Artificial Sequence Core polypeptide 1163Gln Gln Gln Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu 1 5 10 15Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Ile Leu 20 25 30Ala Val Glu Arg Tyr Leu Lys Asp Gln 35 40 1164 45 PRT Artificial Sequence Core polypeptide 1164Ser Gly Ile Val Gln Gln Gln Asn Asn Leu Leu Arg Ala Ile Glu Ala 1 5 10 15Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln 20 25 30Ala Arg Ile Leu Ala Val Glu Arg Tyr Leu Lys Asp Gln 35 40 45 1165 39 PRT Artificial Sequence Core polypeptide 1165Trp Gln Glu Trp Glu Gln Lys Ile Thr Ala Leu Leu Glu Gln Ala Gln 1 5 10 15Ile Gln Gln Glu Lys Asn Glu Tyr Glu Leu Gln Lys Leu Ala Glu Trp 20 25 30Ala Ser Leu Trp Ala Trp Phe 35 1166 38 PRT Artificial Sequence Core polypeptide 1166Trp Gln Glu Trp Glu Gln Lys Ile Thr Ala Leu Leu Glu Gln Ala Gln 1 5 10 15Ile Gln Gln Glu Lys Asn Glu Tyr Glu Leu Gln Lys Leu Ala Glu Trp 20 25 30Ala Ser Leu Trp Ala Trp 35 1167 38 PRT Artificial Sequence Core polypeptide 1167Trp Gln Glu Trp Glu Gln Lys Ile Thr Ala Leu Leu Glu Gln Ala Gln 1 5 10 15Ile Gln Gln Glu Lys Ala Glu Tyr Glu Leu Gln Lys Leu Ala Glu Trp 20 25 30Ala Ser Leu Trp Ala Trp 35 1168 39 PRT Artificial Sequence Core polypeptide 1168Trp Gln Glu Trp Glu Gln Lys Ile Thr Ala Leu Leu Glu Gln Ala Gln 1 5 10 15Ile Gln Gln Glu Lys Asn Glu Tyr Glu Leu Gln Lys Leu Ala Glu Trp 20 25 30Ala Gly Leu Trp Ala Trp Phe 35 1169 38 PRT Artificial Sequence Core polypeptide 1169Trp Gln Glu Trp Glu Gln Lys Ile Thr Ala Leu Leu Glu Gln Ala Gln 1 5 10 15Ile Gln Gln Glu Lys Asn Glu Tyr Glu Leu Gln Lys Leu Ala Glu Trp 20 25 30Ala Gly Leu Trp Ala Trp 35 1170 38 PRT Artificial Sequence Core polypeptide 1170Trp Gln Glu Trp Glu Gln Lys Ile Thr Ala Leu Leu Glu Gln Ala Gln 1 5 10 15Ile Gln Gln Glu Lys Ala Glu Tyr Glu Leu Gln Lys Leu Ala Glu Trp 20 25 30Ala Gly Leu Trp Ala Trp 35 1171 39 PRT Artificial Sequence Core polypeptide 1171Trp Gln Glu Trp Glu Gln Lys Ile Thr Ala Leu Leu Glu Gln Ala Gln 1 5 10 15Ile Gln Gln Glu Lys Asn Glu Tyr Glu Leu Gln Lys Leu Asp Lys Trp 20 25 30Ala Gly Leu Trp Glu Trp Phe 35 1172 18 PRT Artificial Sequence Core polypeptide 1172Trp Gln Glu Trp Gln His Trp Ser Tyr Gly Leu Arg Pro Gly Trp Glu 1 5 10 15Trp Phe 1173 18 PRT Artificial Sequence Core polypeptide 1173Trp Gln Ala Trp Gln His Trp Ser Tyr Gly Leu Arg Pro Gly Trp Ala 1 5 10 15Trp Phe 1174 39 PRT Artificial Sequence Core polypeptide 1174Trp Gln Glu Trp Glu Gln Lys Ile Thr Ala Leu Leu Glu Gln Ala Gln 1 5 10 15Ile Gln Gln Glu Lys Asn Glu Tyr Glu Leu Gln Lys Leu Asp Lys Trp 20 25 30Ala Ser Leu Trp Glu Trp Phe 35 1175 39 PRT Artificial Sequence Core polypeptide 1175Trp Gln Glu Trp Glu Gln Lys Ile Thr Ala Leu Leu Glu Gln Ala Gln 1 5 10 15Ile Gln Gln Glu Lys Asn Glu Tyr Glu Leu Gln Lys Leu Asp Lys Trp 20 25 30Ala Ser Leu Trp Glu Trp Phe 35 1176 35 PRT Artificial Sequence Core polypeptide 1176Trp Gln Glu Trp Glu Gln Lys Ile Thr Ala Leu Leu Glu Gln Ala Gln 1 5 10 15Ile Gln Gln Glu Lys Ile Glu Tyr Glu Leu Gln Lys Leu Ile Glu Trp 20 25 30Glu Trp Phe 35 1177 34 PRT Artificial Sequence Core polypeptide 1177Trp Gln Glu Trp Glu Gln Lys Ile Ala Leu Leu Glu Gln Ala Gln Ile 1 5 10 15Gln Gln Glu Lys Ile Glu Tyr Glu Leu Gln Lys Leu Ile Glu Trp Glu 20 25 30Trp Phe 1178 38 PRT Artificial Sequence Core polypeptide 1178Trp Gln Glu Trp Glu Gln Lys Ile Ala Leu Leu Glu Gln Ala Gln Ile 1 5 10 15Gln Gln Glu Lys Asn Glu Tyr Glu Leu Gln Lys Leu Asp Lys Trp Ala 20 25 30Ser Leu Trp Glu Trp Phe 35 1179 38 PRT Artificial Sequence Core polypeptide 1179Ala Gly Ser Thr Met Gly Ala Arg Ser Met Thr Leu Thr Val Gln Ala 1 5 10 15Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu Leu Arg 20 25 30Ala Ile Glu Ala Gln Gln 35 1180 38 PRT Artificial Sequence Core polypeptide 1180Ala Gly Ser Ala Met Gly Ala Ala Ser Leu Thr Leu Ser Ala Gln Ser 1 5 10 15Arg Thr Leu Leu Ala Gly Ile Val Gln Gln Gln Gln Gln Leu Leu Asp 20 25 30Val Val Lys Arg Gln Gln 35 1181 38 PRT Artificial Sequence Core polypeptide 1181Ala Gly Ser Ala Met Gly Ala Ala Ser Thr Ala Leu Thr Ala Gln Ser 1 5 10 15Arg Thr Leu Leu Ala Gly Ile Val Gln Gln Gln Gln Gln Leu Leu Asp 20 25 30Val Val Lys Arg Gln Gln 35 1182 38 PRT Artificial Sequence Core polypeptide 1182Ala Leu Thr Ala Gln Ser Arg Thr Leu Leu Ala Gly Ile Val Gln Gln 1 5 10 15Gln Gln Gln Leu Leu Asp Val Val Lys Arg Gln Gln Glu Leu Leu Arg 20 25 30Leu Thr Val Trp Gly Thr 35 1183 38 PRT Artificial Sequence Core polypeptide 1183Thr Leu Ser Ala Gln Ser Arg Thr Leu Leu Ala Gly Ile Val Gln Gln 1 5 10 15Gln Gln Gln Leu Leu Asp Val Val Lys Arg Gln Gln Glu Met Leu Arg 20 25 30Leu Thr Val Trp Gly Thr 35 1184 38 PRT Artificial Sequence Core polypeptide 1184Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln 1 5 10 15Gln Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln 20 25 30Leu Thr Val Trp Gly Ile 35 1185 35 PRT Artificial Sequence Core polypeptide 1185Trp Gln Ala Trp Ile Glu Tyr Glu Ala Glu Leu Ser Gln Val Lys Glu 1 5 10 15Lys Ile Glu Gln Ser Leu Ala Tyr Ile Arg Glu Ala Asp Glu Leu Trp 20 25 30Ala Trp Phe 35 1186 35 PRT Artificial Sequence Core polypeptide 1186Trp Gln Ala Trp Ile Glu Tyr Glu Ala Ser Leu Ser Gln Ala Lys Glu 1 5 10 15Lys Ile Glu Glu Ser Lys Ala Tyr Ile Arg Glu Ala Asp Glu Leu Trp 20 25 30Ala Trp Phe 35 1187 35 PRT Artificial Sequence Core polypeptide 1187Trp Gln Ala Trp Ile Glu Tyr Glu Arg Leu Leu Val Gln Ala Lys Leu 1 5 10 15Lys Ile Ala Ile Ala Lys Leu Tyr Ile Ala Lys Glu Leu Leu Glu Trp 20 25 30Ala Trp Phe 35 1188 35 PRT Artificial Sequence Core polypeptide 1188Trp Gln Ala Trp Ile Glu Tyr Glu Arg Leu Leu Val Gln Val Lys Leu 1 5 10 15Lys Ile Ala Ile Ala Leu Leu Tyr Ile Ala Lys Glu Leu Leu Glu Trp 20 25 30Ala Trp Phe 35 1189 35 PRT Artificial Sequence Core polypeptide 1189Trp Gln Ala Trp Ile Glu Leu Glu Arg Leu Leu Val Gln Val Lys Leu 1 5 10 15Lys Leu Ala Ile Ala Lys Leu Glu Ile Ala Lys Glu Leu Leu Glu Trp 20 25 30Ala Trp Phe 35 1190 19 PRT Artificial Sequence Core polypeptide 1190Gly Glu Trp Thr Tyr Asp Asp Ala Thr Lys Thr Phe Thr Val Thr Glu 1 5 10 15Gly Gly His 1191 35 PRT Artificial Sequence Core polypeptide 1191Trp Gln Glu Trp Glu Gln Lys Ile Gly Glu Trp Thr Tyr Asp Asp Ala 1 5 10 15Thr Lys Thr Phe Thr Val Thr Glu Gly Gly His Trp Ala Ser Leu Trp 20 25 30Glu Trp Phe 35 1192 16 PRT Artificial Sequence Core polypeptide 1192Gly Glu Trp Thr Tyr Asp Asp Ala Thr Lys Thr Phe Thr Val Thr Glu 1 5 10 15 1193 32 PRT Artificial Sequence Core polypeptide 1193Trp Gln Glu Trp Glu Gln Lys Ile Gly Glu Trp Thr Tyr Asp Asp Ala 1 5 10 15Thr Lys Thr Phe Thr Val Thr Glu Trp Ala Ser Leu Trp Glu Trp Phe 20 25 30 1194 8 PRT Artificial Sequence Core polypeptide 1194Met His Arg Phe Asp Tyr Arg Thr 1 5 1195 24 PRT Artificial Sequence Core polypeptide 1195Trp Gln Glu Trp Glu Gln Lys Ile Met His Arg Phe Asp Tyr Arg Thr 1 5 10 15Trp Ala Ser Leu Trp Glu Trp Phe 20 1196 11 PRT Artificial Sequence Core polypeptide 1196Met His Arg Phe Asn Trp Ser Thr Gly Gly Gly 1 5 10 1197 27 PRT Artificial Sequence Core polypeptide 1197Trp Gln Glu Trp Glu Gln Lys Ile Met His Arg Phe Asn Trp Ser Thr 1 5 10 15Gly Gly Gly Trp Ala Ser Leu Trp Glu Trp Phe 20 25 1198 8 PRT Artificial Sequence Core polypeptide 1198Met His Arg Phe Asn Trp Ser Thr 1 5 1199 24 PRT Artificial Sequence Core polypeptide 1199Trp Gln Glu Trp Glu Gln Lys Ile Met His Arg Phe Asn Trp Ser Thr 1 5 10 15Trp Ala Ser Leu Trp Glu Trp Phe 20 1200 18 PRT Artificial Sequence Core polypeptide 1200Leu Leu Val Pro Leu Ala Arg Ile Met Thr Met Ser Ser Val His Gly 1 5 10 15Gly Gly 1201 34 PRT Artificial Sequence Core polypeptide 1201Trp Gln Glu Trp Glu Gln Lys Ile Leu Leu Val Pro Leu Ala Arg Ile 1 5 10 15Met Thr Met Ser Ser Val His Gly Gly Gly Trp Ala Ser Leu Trp Glu 20 25 30Trp Phe 1202 15 PRT Artificial Sequence Core polypeptide 1202Leu Leu Val Pro Leu Ala Arg Ile Met Thr Met Ser Ser Val His 1 5 10 15 1203 31 PRT Artificial Sequence Core polypeptide 1203Trp Gln Glu Trp Glu Gln Lys Ile Leu Leu Val Pro Leu Ala Arg Ile 1 5 10 15Met Thr Met Ser Ser Val His Trp Ala Ser Leu Trp Glu Trp Phe 20 25 30 1204 23 PRT Artificial Sequence Core polypeptide 1204Thr Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Asn Glu Tyr 1 5 10 15Glu Leu Gln Lys Leu Asp Lys 20 1205 23 PRT Artificial Sequence Core polypeptide 1205Thr Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Asn Glu Tyr 1 5 10 15Glu Leu Gln Lys Leu Asp Lys 20 1206 23 PRT Artificial Sequence Core polypeptide 1206Thr Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Ile Glu Tyr 1 5 10 15Glu Leu Gln Lys Leu Ile Glu 20 1207 23 PRT Artificial Sequence Core polypeptide 1207Thr Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Ile Glu Tyr 1 5 10 15Glu Leu Gln Lys Leu Ile Glu 20 1208 47 PRT Artificial Sequence Core polypeptide 1208Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu 1 5 10 15Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp 20 25 30Gly Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr 35 40 45 1209 47 PRT Artificial Sequence Core polypeptide 1209Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu 1 5 10 15Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp 20 25 30Gly Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr 35 40 45 1210 36 PRT Artificial Sequence Core polypeptide 1210Gly Ala Ala Ser Leu Thr Leu Ser Ala Gln Ser Arg Thr Leu Leu Ala 1 5 10 15Gly Ile Val Gln Gln Gln Gln Gln Leu Leu Asp Val Val Lys Arg Gln 20 25 30Gln Glu Met Leu 35 1211 40 PRT Artificial Sequence Core polypeptide 1211Gly Ser Ala Met Gly Ala Ala Ser Leu Thr Leu Ser Ala Gln Ser Arg 1 5 10 15Thr Leu Leu Ala Gly Ile Val Gln Gln Gln Gln Gln Leu Leu Asp Val 20 25 30Val Lys Arg Gln Gln Glu Met Leu 35 40 1212 36 PRT Artificial Sequence Core polypeptide 1212Pro Ala Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp 1 5 10 15Val Gln Phe Leu Phe Gly Val Gly Ser Ser Ile Ala Ser Trp Ala Ile 20 25 30Lys Trp Glu Tyr 35 1213 33 PRT Artificial Sequence Core polypeptide 1213Pro Ala Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp 1 5 10 15Val Gln Phe Leu Tyr Gly Val Gly Ser Ser Ile Ala Ser Trp Ala Ile 20 25 30Lys 1214 34 PRT Artificial Sequence Core polypeptide 1214Leu Ser Thr Thr Gln Trp Gln Val Leu Pro Ser Phe Thr Thr Leu Pro 1 5 10 15Ala Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp Val 20 25 30Gln Tyr 1215 31 PRT Artificial Sequence Core polypeptide 1215Phe Arg Lys Phe Pro Glu Ala Thr Phe Ser Arg Gly Ser Gly Pro Arg 1 5 10 15Ile Thr Pro Arg Met Val Asp Phe Pro Phe Arg Leu Trp His Tyr 20 25 30 1216 37 PRT Artificial Sequence Core polypeptide 1216Asp Phe Pro Phe Arg Leu Trp His Phe Pro Thr Ile Asn Tyr Thr Ile 1 5 10 15Phe Lys Val Arg Leu Phe Val Gly Gly Val Glu His Arg Leu Glu Ala 20 25 30Ala Asn Trp Thr Arg 35 1217 32 PRT Artificial Sequence Core polypeptide 1217Tyr Val Gly Gly Val Glu His Arg Leu Glu Ala Ala Asn Trp Thr Arg 1 5 10 15Gly Glu Arg Asp Leu Glu Asp Arg Asp Arg Ser Glu Leu Ser Pro Leu 20 25 30 1218 36 PRT Artificial Sequence Core polypeptide 1218Met Val Tyr Pro Ser Asp Glu Tyr Asp Ala Ser Ile Ser Gln Val Asn 1 5 10 15Glu Glu Ile Asn Gln Ala Leu Ala Tyr Ile Arg Lys Ala Asp Glu Leu 20 25 30Leu Glu Asn Val 35 1219 36 PRT Artificial Sequence Core polypeptide 1219Met Val Tyr Pro Ser Asp Glu Tyr Asp Ala Ser Ile Ser Gln Val Asn 1 5 10 15Glu Glu Ile Asn Gln Ala Leu Ala Tyr Ile Arg Lys Ala Asp Glu Leu 20 25 30Leu Glu Asn Val 35 1220 35 PRT Artificial Sequence Core polypeptide 1220Gly Pro Leu Leu Val Leu Gln Ala Gly Phe Phe Leu Leu Thr Arg Ile 1 5 10 15Leu Thr Ile Pro Gln Ser Leu Asp Ser Trp Trp Thr Ser Leu Asn Phe 20 25 30Leu Gly Gly 35 1221 35 PRT Artificial Sequence Core polypeptide 1221Leu Gly Pro Leu Leu Val Leu Gln Ala Gly Phe Phe Leu Leu Thr Arg 1 5 10 15Ile Leu Thr Ile Pro Gln Ser Leu Asp Ser Trp Trp Thr Ser Leu Asn 20 25 30Phe Leu Gly 35 1222 35 PRT Artificial Sequence Core polypeptide 1222Phe Leu Gly Pro Leu Leu Val Leu Gln Ala Gly Phe Phe Leu Leu Thr 1 5 10 15Arg Ile Leu Thr Ile Pro Gln Ser Leu Asp Ser Trp Trp Thr Ser Leu 20 25 30Asn Phe Leu 35 1223 36 PRT Artificial Sequence Core polypeptide 1223Tyr Thr Ser Leu Ile Gly Ser Leu Ile Glu Glu Ser Gln Ile Gln Gln 1 5 10 15Glu Arg Asn Glu Gln Glu Leu Leu Glu Leu Asp Arg Trp Ala Ser Leu 20 25 30Trp Glu Trp Phe 35 1224 34 PRT Artificial Sequence Core polypeptide 1224Val Tyr Pro Ser Asp Glu Tyr Asp Ala Ser Ile Ser Gln Val Asn Glu 1 5 10 15Glu Ile Asn Gln Ala Leu Ala Tyr Ile Arg Lys Ala Asp Glu Leu Leu 20 25 30Glu His 1225 33 PRT Artificial Sequence Core polypeptide 1225Val Tyr Pro Ser Asp Glu Tyr Asp Ala Ser Ile Ser Gln Val Asn Glu 1 5 10 15Glu Ile Asn Gln Ala Leu Ala Tyr Ile Arg Lys Ala Asp Glu Leu Leu 20 25 30His 1226 32 PRT Artificial Sequence Core polypeptide 1226Val Tyr Pro Ser Asp Glu Tyr Asp Ala Ser Ile Ser Gln Val Asn Glu 1 5 10 15Glu Ile Asn Gln Ala Leu Ala Tyr Ile Arg Lys Ala Asp Glu Leu His 20 25 30 1227 34 PRT Artificial Sequence Core polypeptide 1227Tyr Pro Ser Asp Glu Tyr Asp Ala Ser Ile Ser Gln Val Asn Glu Glu 1 5 10 15Ile Asn Gln Ala Leu Ala Tyr Ile Arg Lys Ala Asp Glu Leu Leu Glu 20 25 30Asn Val 1228 33 PRT Artificial Sequence Core polypeptide 1228Pro Ser Asp Glu Tyr Asp Ala Ser Ile Ser Gln Val Asn Glu Glu Ile 1 5 10 15Asn Gln Ala Leu Ala Tyr Ile Arg Lys Ala Asp Glu Leu Leu Glu Asn 20 25 30Val 1229 32 PRT Artificial Sequence Core polypeptide 1229Ser Asp Glu Tyr Asp Ala Ser Ile Ser Gln Val Asn Glu Glu Ile Asn 1 5 10 15Gln Ala Leu Ala Tyr Ile Arg Lys Ala Asp Glu Leu Leu Glu Asn Val 20 25 30 1230 31 PRT Artificial Sequence Core polypeptide 1230Asp Glu Tyr Asp Ala Ser Ile Ser Gln Val Asn Glu Glu Ile Asn Gln 1 5 10 15Ala Leu Ala Tyr Ile Arg Lys Ala Asp Glu Leu Leu Glu Asn Val 20 25 30 1231 35 PRT Artificial Sequence Core polypeptide 1231Val Tyr Pro Ser Asp Glu Tyr Asp Ala Ser Ile Ser Gln Val Asp Glu 1 5 10 15Glu Ile Asn Gln Ala Leu Ala Tyr Ile Arg Lys Ala Asp Glu Leu Leu 20 25 30Glu Asn Val 35 1232 35 PRT Artificial Sequence Core polypeptide 1232Val Tyr Pro Ser Asp Glu Tyr Asp Ala Ser Ile Ser Gln Val Asn Glu 1 5 10 15Glu Ile Asp Gln Ala Leu Ala Tyr Ile Arg Lys Ala Asp Glu Leu Leu 20 25 30Glu Asn Val 35 1233 35 PRT Artificial Sequence Core polypeptide 1233Val Tyr Pro Ser Asp Glu Tyr Asp Ala Ser Ile Ser Gln Val Asn Glu 1 5 10 15Glu Ile Asn Gln Ala Leu Ala Tyr Ile Arg Lys Ala Asp Glu Leu Leu 20 25 30Glu Asp Val 35 1234 35 PRT Artificial Sequence Core polypeptide 1234Val Tyr Pro Ser Asp Glu Tyr Asp Ala Ser Ile Ser Gln Val Asp Glu 1 5 10 15Glu Ile Asp Gln Ala Leu Ala Tyr Ile Arg Lys Ala Asp Glu Leu Leu 20 25 30Glu Asn Val 35 1235 35 PRT Artificial Sequence Core polypeptide 1235Leu Leu Ser Thr Asn Lys Ala Val Val Ser Leu Ser Asn Gly Val Ser 1 5 10 15Val Leu Thr Ser Lys Val Leu Asp Leu Lys Asn Tyr Ile Asp Lys Gln 20 25 30Leu Leu Pro 35 1236 35 PRT Artificial Sequence Core polypeptide 1236Leu Ser Thr Asn Lys Ala Val Val Ser Leu Ser Asn Gly Val Ser Val 1 5 10 15Leu Thr Ser Lys Val Leu Asp Leu Lys Asn Tyr Ile Asp Lys Gln Leu 20 25 30Leu Pro Ile 35 1237 35 PRT Artificial Sequence Core polypeptide 1237Val Tyr Pro Ser Asp Glu Tyr Asp Ala Ser Ile Ser Gln Val Asn Glu 1 5 10 15Glu Ile Asn Gln Ala Leu Ala Tyr Ile Arg Lys Ala Asp Glu Leu Leu 20 25 30Glu Asn Val 35 1238 27 PRT Artificial Sequence Core polypeptide 1238Asp Glu Tyr Asp Ala Ser Ile Ser Gln Val Asn Glu Glu Ile Asn Gln 1 5 10 15Ala Leu Ala Tyr Ile Arg Glu Ala Asp Glu Leu 20 25 1239 27 PRT Artificial Sequence Core polypeptide 1239Asp Glu Tyr Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln 1 5 10 15Ala Leu Ala Tyr Ile Arg Glu Ala Asp Glu Leu 20 25 1240 35 PRT Artificial Sequence Core polypeptide 1240Asp Asp Glu Cys Leu Asn Ser Val Lys Asn Gly Thr Tyr Asp Phe Pro 1 5 10 15Lys Phe Glu Glu Glu Ser Lys Leu Asn Arg Asn Glu Ile Lys Gly Val 20 25 30Lys Leu Ser 35 1241 36 PRT Artificial Sequence Core polypeptide 1241Asp Asp Glu Ala Asx Leu Asn Ser Val Lys Asn Gly Thr Tyr Asp Phe 1 5 10 15Pro Lys Phe Glu Glu Glu Ser Lys Leu Asn Arg Asn Glu Ile Lys Gly 20 25 30Val Lys Leu Ser 35 1242 40 PRT Artificial Sequence Core polypeptide 1242Tyr His Lys Cys Asp Asp Glu Cys Leu Asn Ser Val Lys Asn Gly Thr 1 5 10 15Phe Asp Phe Pro Lys Phe Glu Glu Glu Ser Lys Leu Asn Arg Asn Glu 20 25 30Ile Lys Gly Val Lys Leu Ser Ser 35 40 1243 42 PRT Artificial Sequence Core polypeptide 1243Tyr His Lys Ala Asx Asp Asp Glu Ala Asx Leu Asn Ser Val Lys Asn 1 5 10 15Gly Thr Phe Asp Phe Pro Lys Phe Glu Glu Glu Ser Lys Leu Asn Arg 20 25 30Asn Glu Ile Lys Gly Val Lys Leu Ser Ser 35 40 1244 36 PRT Artificial Sequence Core polypeptide 1244Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Ile Gln Gln 1 5 10 15Glu Lys Asn Glu Tyr Glu Leu Gln Lys Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Asn Trp Phe 35 1245 36 PRT Artificial Sequence Core polypeptide 1245Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Gln Lys Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Asn Trp Phe 35 1246 36 PRT Artificial Sequence Core polypeptide 1246Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Tyr Glu Leu Gln Lys Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Asn Trp Phe 35 1247 36 PRT Artificial Sequence Core polypeptide 1247Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Ile Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Gln Lys Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Asn Trp Phe 35 1248 36 PRT Artificial Sequence Core polypeptide 1248Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Glu Trp Phe 35 1249 36 PRT Artificial Sequence Core polypeptide 1249Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Ile Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Glu Trp Phe 35 1250 36 PRT Artificial Sequence Core polypeptide 1250Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Tyr Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Glu Trp Phe 35 1251 36 PRT Artificial Sequence Core polypeptide 1251Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Ile Gln Gln 1 5 10 15Glu Lys Asn Glu Tyr Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Glu Trp Phe 35 1252 36 PRT Artificial Sequence Core polypeptide 1252Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Ile Gln Gln 1 5 10 15Glu Lys Asn Glu Tyr Glu Leu Gln Lys Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Glu Trp Phe 35 1253 36 PRT Artificial Sequence Core polypeptide 1253Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Gln Lys Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Glu Trp Phe 35 1254 36 PRT Artificial Sequence Core polypeptide 1254Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Tyr Glu Leu Gln Lys Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Glu Trp Phe 35 1255 36 PRT Artificial Sequence Core polypeptide 1255Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Ile Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Gln Lys Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Glu Trp Phe 35 1256 39 PRT Artificial Sequence Core polypeptide 1256Trp Gln Glu Trp Glu Gln Lys Ile Thr Ala Leu Leu Glu Gln Ala Gln 1 5 10 15Ile Gln Gln Glu Lys Asn Glu Tyr Glu Leu Gln Lys Leu Ala Lys Trp 20 25 30Ala Ser Leu Trp Glu Trp Phe 35 1257 39 PRT Artificial Sequence Core polypeptide 1257Trp Gln Glu Trp Glu Gln Lys Ile Thr Ala Leu Leu Glu Gln Ala Gln 1 5 10 15Ile Gln Gln Glu Lys Asn Glu Tyr Glu Leu Gln Lys Leu Ile Lys Trp 20 25 30Ala Ser Leu Trp Glu Trp Phe 35 1258 39 PRT Artificial Sequence Core polypeptide 1258Trp Gln Glu Trp Glu Gln Lys Ile Thr Ala Leu Leu Glu Gln Ala Gln 1 5 10 15Ile Gln Gln Glu Lys Asn Glu Tyr Glu Leu Gln Lys Leu Ile Glu Trp 20 25 30Ala Gly Leu Trp Glu Trp Phe 35 1259 39 PRT Artificial Sequence Core polypeptide 1259Trp Gln Glu Trp Glu Gln Lys Ile Thr Ala Leu Leu Glu Gln Ala Gln 1 5 10 15Ile Gln Gln Glu Lys Asn Glu Tyr Glu Leu Gln Lys Leu Ile Lys Trp 20 25 30Ala Gly Leu Trp Glu Trp Phe 35 1260 39 PRT Artificial Sequence Core polypeptide 1260Trp Gln Glu Trp Glu Gln Lys Ile Thr Ala Leu Leu Glu Gln Ala Gln 1 5 10 15Ile Gln Gln Glu Lys Asn Glu Tyr Glu Leu Gln Lys Leu Ala Lys Trp 20 25 30Ala Gly Leu Trp Glu Trp Phe 35 1261 39 PRT Artificial Sequence Core polypeptide 1261Trp Gln Glu Trp Glu Gln Lys Ile Thr Ala Leu Leu Glu Gln Ala Gln 1 5 10 15Ile Gln Gln Glu Lys Asn Glu Tyr Glu Leu Gln Lys Leu Ile Glu Trp 20 25 30Ala Gly Leu Trp Ala Trp Phe 35 1262 39 PRT Artificial Sequence Core polypeptide 1262Trp Gln Glu Trp Glu Gln Lys Ile Thr Ala Leu Leu Glu Gln Ala Gln 1 5 10 15Ile Gln Gln Glu Lys Asn Glu Tyr Glu Leu Gln Lys Leu Ala Lys Trp 20 25 30Ala Gly Leu Trp Ala Trp Phe 35 1263 39 PRT Artificial Sequence Core polypeptide 1263Trp Gln Glu Trp Glu Gln Lys Ile Thr Ala Leu Leu Glu Gln Ala Gln 1 5 10 15Ile Gln Gln Glu Lys Asn Glu Tyr Glu Leu Gln Lys Leu Ile Lys Trp 20 25 30Ala Gly Leu Trp Ala Trp Phe 35 1264 35 PRT Artificial Sequence Core polypeptide 1264Trp Gln Glu Trp Glu Gln Lys Ile Thr Ala Leu Leu Glu Gln Ala Gln 1 5 10 15Ile Gln Gln Glu Lys Gly Glu Tyr Glu Leu Gln Lys Leu Asp Lys Trp 20 25 30Glu Trp Phe 35 1265 35 PRT Artificial Sequence Core polypeptide 1265Trp Gln Glu Trp Glu Gln Lys Ile Thr Ala Leu Leu Glu Gln Ala Gln 1 5 10 15Ile Gln Gln Glu Lys Gly Glu Tyr Glu Leu Leu Glu Leu Asp Lys Trp 20 25 30Glu Trp Phe 35 1266 35 PRT Artificial Sequence Core polypeptide 1266Trp Gln Glu Trp Glu Gln Lys Ile Thr Ala Leu Leu Glu Gln Ala Gln 1 5 10 15Ile Gln Gln Glu Lys Gly Glu Tyr Glu Leu Gln Lys Leu Ala Lys Trp 20 25 30Glu Trp Phe 35 1267 35 PRT Artificial Sequence Core polypeptide 1267Trp Gln Glu Trp Glu Gln Lys Ile Thr Ala Leu Leu Glu Gln Ala Gln 1 5 10 15Ile Gln Gln Glu Lys Gly Glu Tyr Glu Leu Gln Lys Leu Asp Glu Trp 20 25 30Glu Trp Phe 35 1268 35 PRT Artificial Sequence Core polypeptide 1268Trp Gln Glu Trp Glu Gln Lys Ile Thr Ala Leu Leu Glu Gln Ala Gln 1 5 10 15Ile Gln Gln Glu Lys Gly Glu Tyr Glu Leu Leu Glu Leu Ala Lys Trp 20 25 30Glu Trp Phe 35 1269 35 PRT Artificial Sequence Core polypeptide 1269Trp Gln Glu Trp Glu Gln Lys Ile Thr Ala Leu Leu Glu Gln Ala Gln 1 5 10 15Ile Gln Gln Glu Lys Asn Glu Tyr Glu Leu Leu Glu Leu Asp Lys Trp 20 25 30Glu Trp Phe 35 1270 39 PRT Artificial Sequence Core polypeptide 1270Trp Gln Glu Trp Glu Gln Lys Ile Thr Ala Leu Leu Glu Gln Ala Gln 1 5 10 15Ile Gln Gln Glu Lys Asn Glu Tyr Glu Leu Leu Glu Leu Ile Glu Trp 20 25 30Ala Ser Leu Trp Glu Trp Phe 35 1271 39 PRT Artificial Sequence Core polypeptide 1271Trp Gln Glu Trp Glu Gln Lys Ile Thr Ala Leu Leu Glu Gln Ala Gln 1 5 10 15Ile Gln Gln Glu Lys Asn Glu Tyr Glu Leu Leu Glu Leu Ile Glu Trp 20 25 30Ala Gly Leu Trp Glu Trp Phe 35 1272 39 PRT Artificial Sequence Core polypeptide 1272Trp Gln Glu Trp Glu Gln Lys Ile Thr Ala Leu Leu Glu Gln Ala Gln 1 5 10 15Ile Gln Gln Glu Lys Asn Glu Tyr Glu Leu Leu Glu Leu Ile Glu Trp 20 25 30Ala Gly Leu Trp Ala Trp Phe 35 1273 39 PRT Artificial Sequence Core polypeptide 1273Trp Gln Glu Trp Glu Arg Glu Ile Thr Ala Leu Leu Glu Gln Ala Gln 1 5 10 15Ile Gln Gln Glu Lys Asn Glu Tyr Glu Leu Gln Lys Leu Ile Glu Trp 20 25 30Ala Ser Leu Trp Glu Trp Phe 35 1274 30 PRT Artificial Sequence Core polypeptide 1274Trp Gln Glu Trp Glu Arg Glu Ile Gln Gln Glu Lys Asn Glu Tyr Glu 1 5 10 15Leu Gln Lys Leu Asp Lys Trp Ala Ser Leu Trp Glu Trp Phe 20 25 30 1275 25 PRT Artificial Sequence Core polypeptide 1275Trp Gln Glu Trp Glu Arg Glu Ile Gln Gln Glu Lys Gly Glu Tyr Glu 1 5 10 15Leu Gln Lys Leu Glu Trp Glu Trp Phe 20 25 1276 29 PRT Artificial Sequence Core polypeptide 1276Trp Gln Glu Trp Gln Ala Gln Ile Gln Gln Glu Lys Asn Glu Tyr Glu 1 5 10 15Leu Gln Lys Leu Asp Trp Ala Ser Leu Trp Glu Trp Phe 20 25 1277 26 PRT Artificial Sequence Core polypeptide 1277Trp Gln Glu Trp Gln Ala Gln Ile Gln Gln Glu Lys Gly Glu Tyr Glu 1 5 10 15Leu Gln Lys Leu Ile Glu Trp Glu Trp Phe 20 25 1278 28 PRT Artificial Sequence Core polypeptide 1278Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys 20 25 1279 28 PRT Artificial Sequence Core polypeptide 1279Leu Glu Glu Asn Ile Thr Ala Leu Leu Glu Glu Ala Gln Ile Gln Gln 1 5 10 15Glu Lys Asn Met Tyr Glu Leu Gln Lys Leu Asn Ser 20 25 1280 28 PRT Artificial Sequence Core polypeptide 1280Leu Glu Ala Asn Ile Ser Gln Ser Leu Glu Gln Ala Gln Ile Gln Gln 1 5 10 15Glu Lys Asn Met Tyr Glu Leu Gln Lys Leu Asn Ser 20 25 1281 28 PRT Artificial Sequence Core polypeptide 1281Asn Asn Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn 1 5 10 15Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu 20 25 1282 28 PRT Artificial Sequence Core polypeptide 1282Asp Phe Leu Glu Glu Asn Ile Thr Ala Leu Leu Glu Glu Ala Gln Ile 1 5 10 15Gln Gln Glu Lys Asn Met Tyr Glu Leu Gln Lys Leu 20 25 1283 28 PRT Artificial Sequence Core polypeptide 1283Arg Tyr Leu Glu Ala Asn Ile Ser Gln Ser Leu Glu Gln Ala Gln Ile 1 5 10 15Gln Gln Glu Lys Asn Met Tyr Glu Leu Gln Lys Leu 20 25 1284 28 PRT Artificial Sequence Core polypeptide 1284Arg Tyr Leu Glu Ala Asn Ile Thr Ala Leu Leu Glu Gln Ala Gln Ile 1 5 10 15Gln Gln Glu Lys Asn Glu Tyr Glu Leu Gln Lys Leu 20 25 1285 30 PRT Artificial Sequence Core polypeptide 1285Asn Asn Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn 1 5 10 15Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys 20 25 30 1286 23 PRT Artificial Sequence Core polypeptide 1286Thr Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Asn Glu Tyr 1 5 10 15Glu Leu Gln Lys Leu Asp Lys 20 1287 23 PRT Artificial Sequence Core polypeptide 1287Thr Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Asn Glu Tyr 1 5 10 15Glu Leu Gln Lys Leu Asp Glu 20 1288 23 PRT Artificial Sequence Core polypeptide 1288Thr Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Asn Glu Tyr 1 5 10 15Glu Leu Gln Lys Leu Ile Glu 20 1289 23 PRT Artificial Sequence Core polypeptide 1289Thr Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Ile Glu Tyr 1 5 10 15Glu Leu Gln Lys Leu Asp Lys 20 1290 23 PRT Artificial Sequence Core polypeptide 1290Thr Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Ile Glu Tyr 1 5 10 15Glu Leu Gln Lys Leu Asp Glu 20 1291 23 PRT Artificial Sequence Core polypeptide 1291Thr Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Ile Glu Tyr 1 5 10 15Glu Leu Gln Lys Leu Ile Glu 20 1292 22 PRT Artificial Sequence Core polypeptide 1292Thr Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Ile Glu Tyr 1 5 10 15Glu Leu Gln Lys Leu Glu 20 1293 23 PRT Artificial Sequence Core polypeptide 1293Thr Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Ile Glu Tyr 1 5 10 15Glu Leu Gln Lys Leu Ala Lys 20 1294 23 PRT Artificial Sequence Core polypeptide 1294Thr Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Ile Glu Tyr 1 5 10 15Glu Leu Gln Lys Leu Ala Glu 20 1295 22 PRT Artificial Sequence Core polypeptide 1295Thr Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Ala Glu Tyr 1 5 10 15Glu Leu Gln Lys Leu Glu 20 1296 22 PRT Artificial Sequence Core polypeptide 1296Thr Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Asn Glu Tyr 1 5 10 15Glu Leu Gln Lys Leu Glu 20 1297 22 PRT Artificial Sequence Core polypeptide 1297Thr Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Gly Glu Tyr 1 5 10 15Glu Leu Gln Lys Leu Glu 20 1298 23 PRT Artificial Sequence Core polypeptide 1298Thr Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Ala Glu Tyr 1 5 10 15Glu Leu Gln Lys Leu Ala Lys 20 1299 23 PRT Artificial Sequence Core polypeptide 1299Thr Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Asn Glu Tyr 1 5 10 15Glu Leu Gln Lys Leu Ala Lys 20 1300 23 PRT Artificial Sequence Core polypeptide 1300Thr Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Gly Glu Tyr 1 5 10 15Glu Leu Gln Lys Leu Ala Lys 20 1301 23 PRT Artificial Sequence Core polypeptide 1301Thr Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Ala Glu Tyr 1 5 10 15Glu Leu Gln Lys Leu Ala Glu 20 1302 23 PRT Artificial Sequence Core polypeptide 1302Thr Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Asn Glu Tyr 1 5 10 15Glu Leu Gln Lys Leu Ala Glu 20 1303 23 PRT Artificial Sequence Core polypeptide 1303Thr Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Gly Glu Tyr 1 5 10 15Glu Leu Gln Lys Leu Ala Glu 20 1304 28 PRT Artificial Sequence Core polypeptide 1304Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln 1 5 10 15Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu 20 25 1305 27 PRT Artificial Sequence Core polypeptide 1305Asp Glu Tyr Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln 1 5 10 15Ala Leu Ala Tyr Ile Arg Glu Ala Asp Glu Leu 20 25 1306 27 PRT Artificial Sequence Core polypeptide 1306Asp Glu Tyr Asp Ala Ser Ile Ser Gln Val Asn Glu Glu Ile Asn Gln 1 5 10 15Ala Leu Ala Tyr Ile Arg Lys Ala Asp Glu Leu 20 25 1307 28 PRT Artificial Sequence Core polypeptide 1307Asp Glu Phe Asp Glu Ser Ile Ser Gln Val Asn Glu Lys Ile Glu Glu 1 5 10 15Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu 20 25 1308 27 PRT Artificial Sequence Core polypeptide 1308Asp Glu Phe Asp Glu Ser Ile Ser Gln Val Asn Glu Lys Ile Glu Glu 1 5 10 15Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu 20 25 1309 10 PRT Artificial Sequence Core polypeptide 1309Gln His Trp Ser Tyr Gly Leu Arg Pro Gly 1 5 10 1310 39 PRT Artificial Sequence Core polypeptide 1310Trp Gln Glu Trp Glu Gln Lys Ile Thr Ala Leu Leu Glu Gln Ala Gln 1 5 10 15Ile Gln Gln Glu Lys Asn Glu Tyr Glu Leu Gln Lys Leu Asp Lys Trp 20 25 30Ala Ser Leu Trp Glu Trp Phe 35 1311 35 PRT Artificial Sequence Core polypeptide 1311Trp Gln Glu Trp Glu Gln Lys Ile Thr Ala Leu Leu Glu Gln Ala Gln 1 5 10 15Ile Gln Gln Glu Lys Ile Glu Tyr Glu Leu Gln Lys Leu Ile Glu Trp 20 25 30Glu Trp Phe 35 1312 35 PRT Artificial Sequence Core polypeptide 1312Val Tyr Pro Ser Asp Glu Tyr Asp Ala Ser Ile Ser Gln Val Asn Glu 1 5 10 15Glu Ile Asn Gln Ala Leu Ala Tyr Ile Arg Lys Ala Asp Glu Leu Leu 20 25 30Glu Asn Val 35 1313 28 PRT Artificial Sequence Core polypeptide 1313Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys 20 25 1314 28 PRT Artificial Sequence Core polypeptide 1314Leu Glu Glu Asn Ile Thr Ala Leu Leu Glu Glu Ala Gln Ile Gln Gln 1 5 10 15Glu Lys Asn Met Tyr Glu Leu Gln Lys Leu Asn Ser 20 25 1315 28 PRT Artificial Sequence Core polypeptide 1315Leu Glu Ala Asn Ile Ser Gln Ser Leu Glu Gln Ala Gln Ile Gln Gln 1 5 10 15Glu Lys Asn Met Tyr Glu Leu Gln Lys Leu Asn Ser 20 25 1316 28 PRT Artificial Sequence Core polypeptide 1316Asn Asn Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn 1 5 10 15Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu 20 25 1317 28 PRT Artificial Sequence Core polypeptide 1317Asp Phe Leu Glu Glu Asn Ile Thr Ala Leu Leu Glu Glu Ala Gln Ile 1 5 10 15Gln Gln Glu Lys Asn Met Tyr Glu Leu Gln Lys Leu 20 25 1318 28 PRT Artificial Sequence Core polypeptide 1318Arg Tyr Leu Glu Ala Asn Ile Ser Gln Ser Leu Glu Gln Ala Gln Ile 1 5 10 15Gln Gln Glu Lys Asn Met Tyr Glu Leu Gln Lys Leu 20 25 1319 28 PRT Artificial Sequence Core polypeptide 1319Arg Tyr Leu Glu Ala Asn Ile Thr Ala Leu Leu Glu Gln Ala Gln Ile 1 5 10 15Gln Gln Glu Lys Asn Glu Tyr Glu Leu Gln Lys Leu 20 25 1320 30 PRT Artificial Sequence Core polypeptide 1320Asn Asn Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn 1 5 10 15Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys 20 25 30 1321 23 PRT Artificial Sequence Core polypeptide 1321Thr Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Asn Glu Tyr 1 5 10 15Glu Leu Gln Lys Leu Asp Lys 20 1322 23 PRT Artificial Sequence Core polypeptide 1322Thr Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Asn Glu Tyr 1 5 10 15Glu Leu Gln Lys Leu Asp Glu 20 1323 23 PRT Artificial Sequence Core polypeptide 1323Thr Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Asn Glu Tyr 1 5 10 15Glu Leu Gln Lys Leu Ile Glu 20 1324 23 PRT Artificial Sequence Core polypeptide 1324Thr Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Ile Glu Tyr 1 5 10 15Glu Leu Gln Lys Leu Asp Lys 20 1325 23 PRT Artificial Sequence Core polypeptide 1325Thr Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Ile Glu Tyr 1 5 10 15Glu Leu Gln Lys Leu Asp Glu 20 1326 23 PRT Artificial Sequence Core polypeptide 1326Thr Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Ile Glu Tyr 1 5 10 15Glu Leu Gln Lys Leu Ile Glu 20 1327 22 PRT Artificial Sequence Core polypeptide 1327Thr Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Ile Glu Tyr 1 5 10 15Glu Leu Gln Lys Leu Glu 20 1328 23 PRT Artificial Sequence Core polypeptide 1328Thr Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Ile Glu Tyr 1 5 10 15Glu Leu Gln Lys Leu Ala Lys 20 1329 23 PRT Artificial Sequence Core polypeptide 1329Thr Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Ile Glu Tyr 1 5 10 15Glu Leu Gln Lys Leu Ala Glu 20 1330 22 PRT Artificial Sequence Core polypeptide 1330Thr Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Ala Glu Tyr 1 5 10 15Glu Leu Gln Lys Leu Glu 20 1331 22 PRT Artificial Sequence Core polypeptide 1331Thr Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Asn Glu Tyr 1 5 10 15Glu Leu Gln Lys Leu Glu 20 1332 22 PRT Artificial Sequence Core polypeptide 1332Thr Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Gly Glu Tyr 1 5 10 15Glu Leu Gln Lys Leu Glu 20 1333 23 PRT Artificial Sequence Core polypeptide 1333Thr Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Ala Glu Tyr 1 5 10 15Glu Leu Gln Lys Leu Ala Lys 20 1334 23 PRT Artificial Sequence Core polypeptide 1334Thr Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Asn Glu Tyr 1 5 10 15Glu Leu Gln Lys Leu Ala Lys 20 1335 23 PRT Artificial Sequence Core polypeptide 1335Thr Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Gly Glu Tyr 1 5 10 15Glu Leu Gln Lys Leu Ala Lys 20 1336 23 PRT Artificial Sequence Core polypeptide 1336Thr Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Ala Glu Tyr 1 5 10 15Glu Leu Gln Lys Leu Ala Glu 20 1337 23 PRT Artificial Sequence Core polypeptide 1337Thr Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Asn Glu Tyr 1 5 10 15Glu Leu Gln Lys Leu Ala Glu 20 1338 23 PRT Artificial Sequence Core polypeptide 1338Thr Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Gly Glu Tyr 1 5 10 15Glu Leu Gln Lys Leu Ala Glu 20 1339 28 PRT Artificial Sequence Core polypeptide 1339Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln 1 5 10 15Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu 20 25 1340 27 PRT Artificial Sequence Core polypeptide 1340Asp Glu Tyr Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln 1 5 10 15Ala Leu Ala Tyr Ile Arg Glu Ala Asp Glu Leu 20 25 1341 27 PRT Artificial Sequence Core polypeptide 1341Asp Glu Tyr Asp Ala Ser Ile Ser Gln Val Asn Glu Glu Ile Asn Gln 1 5 10 15Ala Leu Ala Tyr Ile Arg Lys Ala Asp Glu Leu 20 25 1342 28 PRT Artificial Sequence Core polypeptide 1342Asp Glu Phe Asp Glu Ser Ile Ser Gln Val Asn Glu Lys Ile Glu Glu 1 5 10 15Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu 20 25 1343 27 PRT Artificial Sequence Core polypeptide 1343Asp Glu Phe Asp Glu Ser Ile Ser Gln Val Asn Glu Lys Ile Glu Glu 1 5 10 15Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu 20 25 1344 10 PRT Artificial Sequence Core polypeptide 1344Gln His Trp Ser Tyr Gly Leu Arg Pro Gly 1 5 10 1345 35 PRT Artificial Sequence Core polypeptide 1345Gly Leu Ser Pro Thr Val Trp Leu Ser Val Ile Trp Met Met Trp Tyr 1 5 10 15Trp Gly Pro Ser Leu Tyr Ser Ile Leu Ser Pro Phe Leu Pro Leu Leu 20 25 30Pro Ile Phe 35 1346 36 PRT Artificial Sequence Core polypeptide 1346Val Gly Leu Ser Pro Thr Val Trp Leu Ser Val Ile Trp Met Met Trp 1 5 10 15Tyr Trp Trp Gly Pro Ser Leu Tyr Ser Ile Leu Ser Pro Phe Leu Pro 20 25 30Leu Leu Pro Ile 35 1347 35 PRT Artificial Sequence Core polypeptide 1347Phe Val Gly Leu Ser Pro Thr Val Trp Leu Ser Val Ile Trp Met Met 1 5 10 15Trp Tyr Trp Gly Pro Ser Leu Tyr Ser Ile Leu Ser Pro Phe Leu Pro 20 25 30Leu Leu Pro 35 1348 35 PRT Artificial Sequence Core polypeptide 1348Trp Phe Val Gly Leu Ser Pro Thr Val Trp Leu Ser Val Ile Trp Met 1 5 10 15Met Trp Tyr Trp Gly Pro Ser Leu Tyr Ser Ile Leu Ser Pro Phe Leu 20 25 30Pro Leu Leu 35 1349 35 PRT Artificial Sequence Core polypeptide 1349Gln Trp Phe Val Gly Leu Ser Pro Thr Val Trp Leu Ser Val Ile Trp 1 5 10 15Met Met Trp Tyr Trp Gly Pro Ser Leu Tyr Ser Ile Leu Ser Pro Phe 20 25 30Leu Pro Leu 35 1350 35 PRT Artificial Sequence Core polypeptide 1350Val Gln Trp Phe Val Gly Leu Ser Pro Thr Val Trp Leu Ser Val Ile 1 5 10 15Trp Met Met Trp Tyr Trp Gly Pro Ser Leu Tyr Ser Ile Leu Ser Pro 20 25 30Phe Leu Pro 35 1351 35 PRT Artificial Sequence Core polypeptide 1351Phe Val Gln Trp Phe Val Gly Leu Ser Pro Thr Val Trp Leu Ser Val 1 5 10 15Ile Trp Met Met Trp Tyr Trp Gly Pro Ser Leu Tyr Ser Ile Leu Ser 20 25 30Pro Phe Leu 35 1352 35 PRT Artificial Sequence Core polypeptide 1352Pro Phe Val Gln Trp Phe Val Gly Leu Ser Pro Thr Val Trp Leu Ser 1 5 10 15Val Ile Trp Met Met Trp Tyr Trp Gly Pro Ser Leu Tyr Ser Ile Leu 20 25 30Ser Pro Phe 35 1353 35 PRT Artificial Sequence Core polypeptide 1353Val Pro Phe Val Gln Trp Phe Val Gly Leu Ser Pro Thr Val Trp Leu 1 5 10 15Ser Val Ile Trp Met Met Trp Tyr Trp Gly Pro Ser Leu Tyr Ser Ile 20 25 30Leu Ser Pro 35 1354 35 PRT Artificial Sequence Core polypeptide 1354Leu Val Pro Phe Val Gln Trp Phe Val Gly Leu Ser Pro Thr Val Trp 1 5 10 15Leu Ser Val Ile Trp Met Met Trp Tyr Trp Gly Pro Ser Leu Tyr Ser 20 25 30Ile Leu Ser 35 1355 35 PRT Artificial Sequence Core polypeptide 1355Leu Gln Ala Gly Phe Phe Leu Leu Thr Arg Ile Leu Thr Ile Pro Gln 1 5 10 15Ser Leu Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly Gly Thr Thr 20 25 30Val Ala Leu 35 1356 36 PRT Artificial Sequence Core polypeptide 1356Trp Asn Trp Phe Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Asn Trp Phe 35 1357 36 PRT Artificial Sequence Core polypeptide 1357Tyr Thr Asn Thr Ile Tyr Thr Leu Leu Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Asn Trp Phe 35 1358 36 PRT Artificial Sequence Core polypeptide 1358Tyr Thr Gly Ile Ile Tyr Asn Leu Leu Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Asn Leu 20 25 30Trp Asn Trp Phe 35 1359 36 PRT Artificial Sequence Core polypeptide 1359Tyr Thr Gly Ile Ile Tyr Asn Leu Leu Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Asn Leu 20 25 30Trp Asn Trp Phe 35 1360 36 PRT Artificial Sequence Core polypeptide 1360Tyr Thr Ser Leu Ile Tyr Ser Leu Leu Glu Lys Ser Gln Ile Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Asn Trp Phe 35 1361 36 PRT Artificial Sequence Core polypeptide 1361Tyr Thr Ser Leu Ile Tyr Ser Leu Leu Glu Lys Ser Gln Ile Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Gln Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Asn Trp Phe 35 1362 21 PRT Artificial Sequence Core polypeptide 1362Glu Lys Ser Gln Ile Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu 1 5 10 15Leu Asp Lys Trp Ala 20 1364 21 PRT Artificial Sequence Core polypeptide 1364Glu Gln Ala Gln Ile Gln Gln Glu Lys Asn Glu Tyr Glu Leu Gln Lys 1 5 10 15Leu Asp Lys Trp Ala 20 1365 21 PRT Artificial Sequence Core polypeptide 1365Glu Gln Ala Gln Ile Gln Gln Glu Lys Asn Glu Tyr Glu Leu Gln Lys 1 5 10 15Leu Asp Lys Trp Ala 20 1366 36 PRT Artificial Sequence Core polypeptide 1366Tyr Thr Xaa Leu Ile His Ser Leu Ile Xaa Glu Ser Gln Asn Gln Gln 1 5 10 15Xaa Lys Asn Glu Gln Glu Leu Xaa Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Asn Trp Phe 35 1367 27 PRT Artificial Sequence Core polypeptide 1367Tyr Thr Xaa Leu Ile His Ser Leu Ile Xaa Glu Ser Gln Asn Gln Gln 1 5 10 15Xaa Lys Asn Glu Gln Glu Leu Xaa Glu Leu Asp 20 25 1368 27 PRT Artificial Sequence Core polypeptide 1368Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp 20 25 1369 39 PRT Artificial Sequence Core polypeptide 1369Trp Gln Glu Trp Glu Xaa Lys Ile Thr Ala Leu Leu Xaa Gln Ala Gln 1 5 10 15Ile Gln Gln Xaa Lys Asn Glu Tyr Glu Leu Xaa Lys Leu Asp Lys Trp 20 25 30Ala Ser Leu Trp Glu Trp Phe 35 1370 34 PRT Artificial Sequence Core polypeptide 1370Xaa Lys Ile Thr Ala Leu Leu Xaa Gln Ala Gln Ile Gln Gln Xaa Lys 1 5 10 15Asn Glu Tyr Glu Leu Xaa Lys Leu Asp Lys Trp Ala Ser Leu Trp Glu 20 25 30Trp Phe 1371 30 PRT Artificial Sequence Core polypeptide 1371Trp Gln Glu Trp Glu Xaa Lys Ile Thr Ala Leu Leu Xaa Gln Ala Gln 1 5 10 15Ile Gln Gln Xaa Lys Asn Glu Tyr Glu Leu Xaa Lys Leu Asp 20 25 30 1372 27 PRT Artificial Sequence Core polypeptide 1372Trp Glu Gln Lys Ile Thr Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln 1 5 10 15Glu Lys Asn Glu Tyr Glu Leu Gln Lys Leu Asp 20 25 1373 25 PRT Artificial Sequence Core polypeptide 1373Trp Glu Xaa Lys Ile Thr Ala Leu Leu Xaa Gln Ala Gln Gln Xaa Lys 1 5 10 15Asn Glu Tyr Glu Leu Xaa Lys Leu Asp 20 25 1374 25 PRT Artificial Sequence Core polypeptide 1374Xaa Lys Ile Thr Ala Leu Leu Xaa Gln Ala Gln Ile Gln Gln Xaa Lys 1 5 10 15Asn Glu Tyr Glu Leu Xaa Lys Leu Asp 20 25 1375 25 PRT Artificial Sequence Core polypeptide 1375Gln Lys Ile Thr Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys 1 5 10 15Asn Glu Tyr Glu Leu Gln Lys Leu Asp 20 25 1376 32 PRT Artificial Sequence Core polypeptide 1376Val Tyr Pro Ser Asp Glu Tyr Asp Ala Ser Ile Ser Gln Val Asn Glu 1 5 10 15Glu Ile Asn Gln Ala Leu Ala Tyr Ile Arg Lys Ala Asp Glu Leu Leu 20 25 30 1377 25 PRT Artificial Sequence Core polypeptide 1377Gln Lys Ile Thr Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys 1 5 10 15Asn Glu Tyr Glu Leu Gln Lys Leu Asp 20 25 1378 31 PRT Artificial Sequence Core polypeptide 1378Val Tyr Pro Ser Asp Glu Tyr Asp Ala Ser Ile Ser Gln Val Asn Glu 1 5 10 15Glu Ile Asn Gln Ala Leu Ala Tyr Ile Arg Lys Ala Asp Glu Leu 20 25 30 1379 30 PRT Artificial Sequence Core polypeptide 1379Trp Gln Glu Trp Glu Gln Lys Ile Thr Ala Leu Leu Glu Gln Ala Gln 1 5 10 15Ile Gln Gln Glu Lys Asn Glu Tyr Glu Leu Gln Lys Leu Asp 20 25 30 1380 34 PRT Artificial Sequence Core polypeptide 1380Val Tyr Pro Ser Asp Glu Tyr Asp Ala Ser Ile Ser Gln Val Asn Glu 1 5 10 15Glu Ile Asn Gln Ala Leu Ala Tyr Ile Arg Lys Ala Asp Glu Leu Leu 20 25 30Glu Asn 1381 34 PRT Artificial Sequence Core polypeptide 1381Gln Lys Ile Thr Ala Leu Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys 1 5 10 15Asn Glu Tyr Glu Leu Gln Lys Leu Asp Lys Trp Ala Ser Leu Trp Glu 20 25 30Trp Phe 1382 35 PRT Artificial Sequence Core polypeptide 1382Ser Thr Asn Lys Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu 1 5 10 15Thr Ser Lys Val Leu Asp Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu 20 25 30Pro Ile Val 35 1383 35 PRT Artificial Sequence Core polypeptide 1383Thr Asn Lys Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr 1 5 10 15Ser Lys Val Leu Asp Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu Pro 20 25 30Ile Val Asn 35 1384 35 PRT Artificial Sequence Core polypeptide 1384Asn Lys Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Ser 1 5 10 15Lys Val Leu Asp Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu Pro Ile 20 25 30Val Asn Lys 35 1385 35 PRT Artificial Sequence Core polypeptide 1385Lys Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Ser Lys 1 5 10 15Val Leu Asp Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu Pro Ile Val 20 25 30Asn Lys Gln 35 1386 36 PRT Artificial Sequence Core polypeptide 1386Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Ser Lys Val 1 5 10 15Leu Asp Leu Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu Pro Ile Val 20 25 30Asn Lys Gln Ser 35 1387 34 PRT Artificial Sequence Core polypeptide 1387Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Ser Lys Val Leu 1 5 10 15Asp Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu Pro Ile Val Asn Lys 20 25 30Gln Ser 1388 34 PRT Artificial Sequence Core polypeptide 1388Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Ser Lys Val Leu Asp 1 5 10 15Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu Pro Ile Val Asn Lys Gln 20 25 30Ser Ser 1389 34 PRT Artificial Sequence Core polypeptide 1389Ser Leu Ser Asn Gly Val Ser Val Leu Thr Ser Lys Val Leu Asp Leu 1 5 10 15Lys Asn Tyr Ile Asp Lys Gln Leu Leu Pro Ile Val Asn Lys Gln Ser 20 25 30Ser Ile 1390 34 PRT Artificial Sequence Core polypeptide 1390Leu Ser Asn Gly Val Ser Val Leu Thr Ser Lys Val Leu Asp Leu Lys 1 5 10 15Asn Tyr Ile Asp Lys Gln Leu Leu Pro Ile Val Asn Lys Gln Ser Ser 20 25 30Ile Ser 1391 34 PRT Artificial Sequence Core polypeptide 1391Ser Asn Gly Val Ser Val Leu Thr Ser Lys Val Leu Asp Leu Lys Asn 1 5 10 15Tyr Ile Asp Lys Gln Leu Leu Pro Ile Val Asn Lys Gln Ser Ser Ile 20 25 30Ser Asn 1392 34 PRT Artificial Sequence Core polypeptide 1392Asn Gly Val Ser Val Leu Thr Ser Lys Val Leu Asp Leu Lys Asn Tyr 1 5 10 15Ile Asp Lys Gln Leu Leu Pro Ile Val Asn Lys Gln Ser Ser Ile Ser 20 25 30Asn Ile 1393 34 PRT Artificial Sequence Core polypeptide 1393Gly Val Ser Val Leu Thr Ser Lys Val Leu Asp Leu Lys Asn Tyr Ile 1 5 10 15Asp Lys Gln Leu Leu Pro Ile Val Asn Lys Gln Ser Ser Ile Ser Asn 20 25 30Ile Glu 1394 34 PRT Artificial Sequence Core polypeptide 1394Val Ser Val Leu Thr Ser Lys Val Leu Asp Leu Lys Asn Tyr Ile Asp 1 5 10 15Lys Gln Leu Leu Pro Ile Val Asn Lys Gln Ser Ser Ile Ser Asn Ile 20 25 30Glu Thr 1395 34 PRT Artificial Sequence Core polypeptide 1395Ser Val Leu Thr Ser Lys Val Leu Asp Leu Lys Asn Tyr Ile Asp Lys 1 5 10 15Gln Leu Leu Pro Ile Val Asn Lys Gln Ser Ser Ile Ser Asn Ile Glu 20 25 30Thr Val 1396 34 PRT Artificial Sequence Core polypeptide 1396Val Leu Thr Ser Lys Val Leu Asp Leu Lys Asn Tyr Ile Asp Lys Gln 1 5 10 15Leu Leu Pro Ile Val Asn Lys Gln Ser Ser Ile Ser Asn Ile Glu Thr 20 25 30Val Ile 1397 33 PRT Artificial Sequence Core polypeptide 1397Leu Thr Ser Lys Val Leu Asp Lys Asn Tyr Ile Asp Lys Gln Leu Leu 1 5 10 15Pro Ile Val Asn Lys Gln Ser Ser Ile Ser Asn Ile Glu Thr Val Ile 20 25 30Glu 1398 34 PRT Artificial Sequence Core polypeptide 1398Thr Ser Lys Val Leu Asp Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu 1 5 10 15Pro Ile Val Asn Lys Gln Ser Ser Ile Ser Asn Ile Glu Thr Val Ile 20 25 30Glu Phe 1399 34 PRT Artificial Sequence Core polypeptide 1399Ser Lys Val Leu Asp Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu Pro 1 5 10 15Ile Val Asn Lys Gln Ser Ser Ile Ser Asn Ile Glu Thr Val Ile Glu 20 25 30Phe Gln 1400 34 PRT Artificial Sequence Core polypeptide 1400Lys Val Leu Asp Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu Pro Ile 1 5 10 15Val Asn Lys Gln Ser Ser Ile Ser Asn Ile Glu Thr Val Ile Glu Phe 20 25 30Gln Gln 1401 34 PRT Artificial Sequence Core polypeptide 1401Val Leu Asp Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu Pro Ile Val 1 5 10 15Asn Lys Gln Ser Ser Ile Ser Asn Ile Glu Thr Val Ile Glu Phe Gln 20 25 30Gln Lys 1402 34 PRT Artificial Sequence Core polypeptide 1402Leu Asp Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu Pro Ile Val Asn 1 5 10 15Lys Gln Ser Ser Ile Ser Asn Ile Glu Thr Val Ile Glu Phe Gln Gln 20 25 30Lys Asn 1403 34 PRT Artificial Sequence Core polypeptide 1403Asp Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu Pro Ile Val Asn Lys 1 5 10 15Gln Ser Ser Ile Ser Asn Ile Glu Thr Val Ile Glu Phe Gln Gln Lys 20 25 30Asn Asn 1404 34 PRT Artificial Sequence Core polypeptide 1404Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu Pro Ile Val Asn Lys Gln 1 5 10 15Ser Ser Ile Ser Asn Ile Glu Thr Val Ile Glu Phe Gln Gln Lys Asn 20 25 30Asn Arg 1405 34 PRT Artificial Sequence Core polypeptide 1405Lys Asn Tyr Ile Asp Lys Gln Leu Leu Pro Ile Val Asn Lys Gln Ser 1 5 10 15Ser Ile Ser Asn Ile Glu Thr Val Ile Glu Phe Gln Gln Lys Asn Asn 20 25 30Arg Leu 1406 35 PRT Artificial Sequence Core polypeptide 1406Asn Tyr Ile Asp Lys Gln Leu Leu Pro Ile Val Asn Lys Gln Ser Ile 1 5 10 15Ser Ile Ser Asn Ile Glu Thr Val Ile Glu Phe Gln Gln Lys Asn Asn 20 25 30Arg Leu Leu 35 1407 34 PRT Artificial Sequence Core polypeptide 1407Tyr Ile Asp Lys Gln Leu Leu Pro Ile Val Asn Lys Gln Ser Ser Ile 1 5 10 15Ser Asn Ile Glu Thr Val Ile Glu Phe Gln Gln Lys Asn Asn Arg Leu 20 25 30Leu Glu 1408 34 PRT Artificial Sequence Core polypeptide 1408Ile Asp Lys Gln Leu Leu Pro Ile Val Asn Lys Gln Ser Ser Ile Ser 1 5 10 15Asn Ile Glu Thr Val Ile Glu Phe Gln Gln Lys Asn Asn Arg Leu Leu 20 25 30Glu Ile 1409 34 PRT Artificial Sequence Core polypeptide 1409Asp Lys Gln Leu Leu Pro Ile Val Asn Lys Gln Ser Ser Ile Ser Asn 1 5 10 15Ile Glu Thr Val Ile Glu Phe Gln Gln Lys Asn Asn Arg Leu Leu Glu 20 25 30Ile Thr 1410 34 PRT Artificial Sequence Core polypeptide 1410Lys Gln Leu Leu Pro Ile Val Asn Lys Gln Ser Ser Ile Ser Asn Ile 1 5 10 15Glu Thr Val Ile Glu Phe Gln Gln Lys Asn Asn Arg Leu Leu Glu Ile 20 25 30Thr Arg 1411 34 PRT Artificial Sequence Core polypeptide 1411Gln Leu Leu Pro Ile Val Asn Lys Gln Ser Ser Ile Ser Asn Ile Glu 1 5 10 15Thr Val Ile Glu Phe Gln Gln Lys Asn Asn Arg Leu Leu Glu Ile Thr 20 25 30Arg Glu 1412 23 PRT Artificial Sequence Core polypeptide 1412Val Tyr Pro Ser Asp Glu Tyr Asp Ala Ser Ile Ser Gln Val Asn Glu 1 5 10 15Glu Ile Asn Gln Ala Leu Ala 20 1413 23 PRT Artificial Sequence Core polypeptide 1413Gln Val Asn Glu Glu Ile Asn Gln Ala Leu Ala Tyr Ile Arg Lys Ala 1 5 10 15Asp Glu Leu Leu Glu Asn Val 20 1414 35 PRT Artificial Sequence Core polypeptide 1414Val Tyr Pro Ser Asp Glu Tyr Asp Ala Ser Ile Ser Gln Val Asn Glu 1 5 10 15Glu Ile Asn Gln Ala Leu Ala Tyr Ile Arg Lys Ala Asp Glu Leu Leu 20 25 30Glu Asn Val 35 1415 27 PRT Artificial Sequence Core polypeptide 1415Asp Glu Tyr Asp Ala Ser Ile Ser Gln Val Asn Glu Glu Ile Asn Gln 1 5 10 15Ala Leu Ala Tyr Ile Arg Glu Ala Asp Glu Leu 20 25 1416 27 PRT Artificial Sequence Core polypeptide 1416Asp Glu Tyr Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln 1 5 10 15Ala Leu Ala Tyr Ile Arg Glu Ala Asp Glu Leu 20 25 1417 35 PRT Artificial Sequence Core polypeptide 1417Asp Asp Glu Cys Leu Asn Ser Val Lys Asn Gly Thr Tyr Asp Phe Pro 1 5 10 15Lys Phe Glu Glu Glu Ser Lys Leu Asn Arg Asn Glu Ile Lys Gly Val 20 25 30Lys Leu Ser 35 1418 34 PRT Artificial Sequence Core polypeptide 1418Asp Asp Glu Leu Asn Ser Val Lys Asn Gly Thr Tyr Asp Phe Pro Lys 1 5 10 15Phe Glu Glu Glu Ser Lys Leu Asn Arg Asn Glu Ile Lys Gly Val Lys 20 25 30Leu Ser 1419 39 PRT Artificial Sequence Core polypeptide 1419Tyr His Lys Cys Asp Asp Glu Cys Leu Asn Ser Val Lys Asn Gly Thr 1 5 10 15Phe Asp Phe Pro Lys Phe Glu Glu Glu Ser Lys Leu Asn Arg Glu Ile 20 25 30Lys Gly Val Lys Leu Ser Ser 35 1420 38 PRT Artificial Sequence Core polypeptide 1420Tyr His Lys Asp Asp Glu Leu Asn Ser Val Lys Asn Gly Thr Phe Asp 1 5 10 15Phe Pro Lys Phe Glu Glu Glu Ser Lys Leu Asn Arg Asn Glu Ile Lys 20 25 30Gly Val Lys Leu Ser Ser 35 1421 36 PRT Artificial Sequence Core polypeptide 1421Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Tyr Glu Leu Gln Lys Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Asn Trp Phe 35 1422 36 PRT Artificial Sequence Core polypeptide 1422Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Ile Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Gln Lys Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Asn Trp Phe 35 1423 36 PRT Artificial Sequence Core polypeptide 1423Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Glu Trp Phe 35 1424 36 PRT Artificial Sequence Core polypeptide 1424Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Ile Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Glu Trp Phe 35 1425 36 PRT Artificial Sequence Core polypeptide 1425Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Tyr Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Glu Trp Phe 35 1426 36 PRT Artificial Sequence Core polypeptide 1426Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Ile Gln Gln 1 5 10 15Glu Lys Asn Glu Tyr Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Glu Trp Phe 35 1427 35 PRT Artificial Sequence Core polypeptide 1427Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Ile Gln Gln 1 5 10 15Glu Lys Asn Glu Tyr Glu Leu Gln Lys Leu Asp Trp Ala Ser Leu Trp 20 25 30Glu Trp Phe 35 1428 36 PRT Artificial Sequence Core polypeptide 1428Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Gln Lys Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Glu Trp Phe 35 1429 36 PRT Artificial Sequence Core polypeptide 1429Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 1 5 10 15Glu Lys Asn Glu Tyr Glu Leu Gln Lys Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Glu Trp Phe 35 1430 36 PRT Artificial Sequence Core polypeptide 1430Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Ile Gln Gln 1 5 10 15Glu Lys Asn Glu Gln Glu Leu Gln Lys Leu Asp Lys Trp Ala Ser Leu 20 25 30Trp Glu Trp Phe 35 1431 35 PRT Artificial Sequence Core polypeptide 1431Trp Gln Glu Trp Glu Gln Lys Ile Thr Ala Leu Leu Glu Gln Ala Gln 1 5 10 15Ile Gln Gln Glu Lys Asn Glu Tyr Glu Leu Gln Lys Leu Asp Lys Trp 20 25 30Glu Trp Phe 35 1432 39 PRT Artificial Sequence Core polypeptide 1432Trp Gln Glu Trp Glu Gln Lys Ile Thr Ala Leu Leu Glu Gln Ala Gln 1 5 10 15Ile Gln Gln Glu Lys Asn Glu Tyr Glu Leu Gln Lys Leu Ile Glu Trp 20 25 30Ala Ser Leu Trp Glu Trp Phe 35 1433 8 PRT Artificial Sequence Core polypeptide 1433Trp Ala Ser Leu Trp Glu Trp Phe 1 5 1434 35 PRT Artificial Sequence Core polypeptide 1434Trp Gln Glu Trp Asp Glu Tyr Asp Ala Ser Ile Ser Gln Val Asn Glu 1 5 10 15Lys Ile Asn Gln Ala Leu Ala Tyr Ile Arg Glu Ala Asp Glu Leu Trp 20 25 30Ala Trp Phe 35 1435 35 PRT Artificial Sequence Core polypeptide 1435Trp Gln Ala Trp Asp Glu Tyr Asp Ala Ser Ile Ser Gln Val Asn Glu 1 5 10 15Lys Ile Asn Gln Ala Leu Ala Tyr Ile Arg Glu Ala Asp Glu Leu Trp 20 25 30Ala Trp Phe 35 1436 31 PRT Artificial Sequence Core polypeptide 1436Trp Gln Ala Trp Asp Glu Tyr Asp Ala Ser Ile Ser Asp Val Asn Glu 1 5 10 15Lys Ile Asn Gln Ala Leu Ala Tyr Ile Arg Glu Ala Asp Glu Leu 20 25 30 1437 8 PRT SIV and HIV-2 1437Trp Leu Glu Trp Glu Arg Gln Ile 1 5 1438 8 PRT SIV and HIV-2 1438Trp Leu Glu Trp Glu Lys Gln Ile 1 5 1439 8 PRT SIV and HIV-2 1439Trp Gln Gln Trp Glu Gln Gln Ile 1 5 1440 8 PRT SIV and HIV-2 1440Trp Gln Gln Trp Glu Lys Gln Ile 1 5 1441 8 PRT SIV and HIV-2 1441Trp Gln Glu Trp Glu His Lys Ile 1 5 1442 8 PRT SIV and HIV-2 1442Trp Gln Glu Trp Glu Gly Lys Ile 1 5 1443 8 PRT SIV and HIV-2 1443Trp Gln Glu Trp Glu Gln Gln Ile 1 5 1444 8 PRT SIV and HIV-2 1444Trp Gln Lys Trp Glu Gln Gln Ile 1 5 1445 8 PRT SIV and HIV-2 1445Trp Gln Glu Trp Glu Gln Arg Ile 1 5 1446 8 PRT HIV-1 1446Trp Leu Gln Trp Asp Lys Glu Ile 1 5 1447 8 PRT HIV-1 1447Trp Met Asp Trp Glu Arg Glu Ile 1 5 1448 8 PRT HIV-1 1448Trp Met Glu Trp Glu Lys Glu Ile 1 5 1449 8 PRT HIV-1 1449Trp Met Glu Trp Asp Arg Glu Ile 1 5 1450 8 PRT HIV-1 1450Trp Met Glu Trp Glu Arg Glu Ile 1 5 1451 8 PRT HIV-1 1451Trp Ile Glu Trp Glu Arg Glu Ile 1 5 1452 8 PRT HIV-1 1452Trp Ile Glu Trp Asp Arg Glu Ile 1 5 1453 8 PRT HIV-1 1453Trp Met Gln Trp Asp Arg Glu Ile 1 5 1454 8 PRT HIV-1 1454Trp Ile Gln Trp Glu Arg Glu Ile 1 5 1455 8 PRT HIV-1 1455Trp Gly Ile Trp Arg Trp Gly Ile 1 5 1456 8 PRT HIV-1 1456Trp Ile Gln Trp Asp Arg Glu Ile 1 5 1457 8 PRT HIV-1 1457Trp Ile Gln Trp Glu Lys Glu Ile 1 5 1458 8 PRT HIV-1 1458Trp Met Gln Trp Glu Lys Glu Ile 1 5 1459 8 PRT HIV-1 1459Trp Gln Gln Trp Asp Gln His Ile 1 5 1460 8 PRT HIV-1 1460Trp Met Gln Trp Glu Arg Glu Ile 1 5 1461 8 PRT HIV-1 1461Trp Gln Glu Trp Asp Arg Gln Ile 1 5 1462 8 PRT HIV-1 1462Trp Gln Gln Trp Asp Gln Gln Ile 1 5 1463 8 PRT HIV-1 1463Trp Ile Glu Trp Lys Arg Glu Ile 1 5 1464 8 PRT HIV-1 1464Trp Met Glu Trp Glu Met Glu Ile 1 5 1465 8 PRT HIV-1 1465Trp Ile Glu Trp Glu Lys Glu Ile 1 5 1466 8 PRT HIV-1 1466Trp Met Gln Trp Lys Arg Glu Ile 1 5 1467 8 PRT HIV-1 1467Trp Met Glu Trp Asn Arg Glu Ile 1 5 1468 8 PRT HIV-1 1468Trp Arg Glu Trp Asp Arg Glu Ile 1 5 1469 8 PRT HIV-1 1469Trp Thr Glu Trp Glu Arg Glu Ile 1 5 1470 8 PRT HIV-1 1470Trp Leu Glu Trp Glu Arg Glu Ile 1 5 1471 8 PRT HIV-1 1471Trp Met Gly Trp Glu Arg Glu Ile 1 5 1472 8 PRT HIV-1 1472Trp Gln Glu Trp Asp Gln Gln Ile 1 5 1473 8 PRT HIV-1 1473Trp Met Lys Trp Glu Arg Glu Ile 1 5 1474 8 PRT SIV 1474Trp Ala Gly Leu Trp Glu Trp Phe 1 5 1475 8 PRT SIV 1475Trp Ser Asn Phe Trp Ser Trp Phe 1 5 1476 8 PRT SIV 1476Trp Asp Ser Leu Trp Ser Trp Phe 1 5 1477 8 PRT SIV 1477Trp Ser Gly Phe Trp Ser Trp Phe 1 5 1478 8 PRT SIV 1478Trp Ser Ser Leu Trp Asn Trp Phe 1 5 1479 8 PRT SIV 1479Trp Ser Asp Phe Trp Ser Trp Phe 1 5 1480 8 PRT SIV 1480Trp Ser Asp Ile Trp Ser Trp Val 1 5 1481 8 PRT SIV 1481Trp Ala Ser Leu Trp Asn Trp Phe 1 5 1482 8 PRT SIV 1482Trp Ser Ser Phe Trp Ser Trp Phe 1 5 1483 8 PRT HIV-2 1483Trp Asp Val Phe Gly Asn Trp Phe 1 5 1484 8 PRT HIV-2 1484Trp Asp Val Phe Thr Asn Trp Leu 1 5 1485 8 PRT HIV-2 1485Trp Asp Ile Phe Gly Asn Trp Phe 1 5 1486 8 PRT HIV-2 1486Trp Asp Val Phe Gly Asn Trp Leu 1 5 1487 8 PRT HIV-2 1487Trp Asp Ile Phe Gly Asn Trp Ser 1 5 1488 8 PRT HIV-2 1488Trp Asp Val Phe Ser Asn Trp Phe 1 5 1489 8 PRT HIV-2 1489Trp Asp Ile Leu Gly Asn Trp Phe 1 5 1490 8 PRT HIV-1 1490Trp Ala Asn Leu Trp Asn Trp Phe 1 5 1491 8 PRT HIV-1 1491Trp Ala Ser Leu Trp Asn Trp Phe 1 5 1492 8 PRT HIV-1 1492Trp Glu Asn Leu Trp Asn Trp Phe 1 5 1493 8 PRT HIV-1 1493Trp Ala Ser Leu Trp Asn Trp Val 1 5 1494 8 PRT HIV-1 1494Trp Glu Asn Leu Trp Ser Trp Phe 1 5 1495 8 PRT HIV-1 1495Trp Asp Ser Leu Trp Gly Trp Phe 1 5 1496 8 PRT HIV-1 1496Trp Asp Ser Leu Trp Asn Trp Phe 1 5 1497 8 PRT HIV-1 1497Trp Ala Ser Leu Trp Thr Trp Phe 1 5 1498 8 PRT HIV-1 1498Trp Lys Asn Leu Trp Asn Trp Phe 1 5 1499 8 PRT HIV-1 1499Trp Thr Ser Leu Trp Ser Trp Phe 1 5 1500 8 PRT HIV-1 1500Trp Ala Ser Ile Trp Asn Trp Leu 1 5 1501 8 PRT HIV-1 1501Trp Gln Asn Leu Trp Asn Trp Phe 1 5 1502 8 PRT HIV-1 1502Trp Gln Asn Leu Trp Ser Trp Phe 1 5 1503 8 PRT HIV-1 1503Trp Pro Asn Leu Trp Asn Trp Phe 1 5 1504 8 PRT HIV-1 1504Trp Ala Ser Leu Trp Ser Trp Phe 1 5 1505 8 PRT HIV-1 1505Trp Ser Ser Leu Trp Asn Trp Phe 1 5 1506 8 PRT HIV-1 1506Trp Gly Ser Leu Trp Ser Trp Phe 1 5 1507 8 PRT HIV-1 1507Trp Ala Asn Leu Trp Ser Trp Phe 1 5 1508 8 PRT HIV-1 1508Trp Ala Gly Leu Trp Asn Trp Phe 1 5 1509 8 PRT HIV-1 1509Trp Thr Asn Leu Trp Asn Trp Phe 1 5 1510 8 PRT HIV-1 1510Trp Pro Ser Leu Trp Asn Trp Phe 1 5 1511 8 PRT HIV-1 1511Trp Ala Gly Leu Trp Ser Trp Phe 1 5 1512 8 PRT HIV-1 1512Trp Ala Ser Leu Trp Thr Trp Ser 1 5 1513 50 PRT HIV-1 1513Asn Asn Met Thr Trp Met Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr 1 5 10 15Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys 20 25 30Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn 35 40 45Trp Phe 50 1514 36 PRT HIV-1 1514Leu Glu Ala Asn Ile Ser Gln Ser Leu Glu Gln Ala Gln Ile Gln Gln 1 5 10 15Glu Lys Asn Met Tyr Glu Leu Gln Lys Leu Asn Ser Trp Asp Val Phe 20 25 30Thr Asn Trp Leu 35 1515 30 PRT HIV-1 1515Asn Asn Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn 1 5 10 15Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys 20 25 30

Claims

1. A hybrid polypeptide comprising an enhancer peptide sequence linked to a core polypeptide, wherein the enhancer peptide comprises an amino-terminal:WXXWXXXI, WXXWXXX, WXXWXX, WXXWX, WXXW, WXXXWXWX, XXXWXWX, XXWXWX, XWXWX, WXWX, WXXXWXW, WXXXWX WXXXW, IXXXWXXW, XXXWXXW, XXWXXW, XWXXW, XWXWXXXW, XWXWXXX, XWXWXX, XWXWX, XWXW, WXWXXXW, or XWXXXW, and wherein the core polypeptide comprises the following amino acid sequence: TALLEQAQIQQEKNEYELQKLDK; (SEQ ID NO:1286).

2. The hybrid polypeptide of claim 1, further comprising an enhancer peptide sequence linked to the carboxy-terminal end of the core polypeptide.

3. A hybrid polypeptide comprising an enhancer peptide sequence linked to a core polypeptide, wherein the enhancer peptide sequence comprises WQEWEQKI (SEQ ID NO:1129) or WASLWEWF (SEQ ID NO:1433) and the core polypeptide comprises the following amino acid sequence:TALLEQAQIQQEKNEYELQKLDK (SEQ ID NO:1286).

4. A method for enhancing the pharmacokinetic properties of a core polypeptide, comprising linking an enhancer peptide sequence to the core polypeptide to produce a hybrid polypeptide, wherein the enhancer peptide sequence comprises:WXXWXXXI, WXXWXXX, WXXWXX, WXXWX, WXXW, WXXXWXWX, XXXWXWX, XXWXWX, XWXWX, WXWX, WXXXWXW, WXXXWX, WXXXW, IXXXWXXW, XXXWXXW, XXWXXW, XWXXW, XWXWXXXW, XWXWXXX, XWXWXX, XWXWX, XWXW, WXWXXXW, or XWXXXW, and wherein the core polypeptide comprises TALLEQAQIQQEKNEYELQKLDK (SEO ID NO:1286) such that, when introduced into a living system, the hybrid polypeptide exhibits enhanced pharmacokinetic properties relative to those exhibited by the core polypeptide.

5. A polypeptide comprising the amino acid sequence:WQEWEQKITALLEQAQIQQEKNEYELQKLDKWASLWEWF (SEQ ID NO:1310).

6. The polypeptide of claim 5, further comprising an amino terminal acetyl group and a carboxy terminal amido group.

7. A hybrid polypeptide comprising an enhancer peptide sequence linked to a core polypeptide, wherein the enhancer peptide sequence comprises a carboxy-terminal:WXXWXXXI, WXXWXXX, WXXWXX, WXXWX, WXXW, WXXXWXWX, XXXWXWX, XXWXWX, XWXWX, WXWX, WXXXWXW, WXXXWX, WXXXW, IXXXWXXW, XXXWXXW, XXWXXW, XWXXW, XWXWXXXW, XWXWXXX, XWXWXX, XWXWX, XWXW, WXWXXXW, or XWXXXW, and wherein the core polypeptide comprises the following amino acid sequence: TALLEQAQIQQEKNEYELQKLDK (SEQ ID NO:1286).

8. The hybrid polypeptide of claim 7, further comprising an enhancer peptide sequence linked to the amino-terminal end of the core polypeptide.

9. The hybrid polypeptide of claims 1,2, 8, 3, or 7 further comprising an amino terminal acetyl group and a carboxy terminal amido group.

10. A polypeptide comprising TALLEQAQIQQEKNEYELQKLDK (SEQ ID NO:1286).

11. The polypeptide of claim 10, further comprising an amino terminal acetyl group and a carboxy terminal amido group.

12. A pharmaceutical composition comprising the polypeptide:TALLEQAQIQQEKNEYELQKLDK (SEQ ID NO:1286), and a pharmaceutically acceptable carrier.

13. The pharmaceutical composition of claim 12, wherein the polypeptide further comprises an amino terminal acetyl group and a carboxy terminal amido group.

14. A pharmaceutical composition comprising the polypeptide:WQEWEQKITALLEQAQIQQEKNEYELQKLDKWASLWEWF (SEQ ID NO:1310), and a pharmaceutically acceptable carrier.

15. The pharmaceutical composition of claim 14, wherein the polypeptide further comprises an amino terminal acetyl group and a carboxy terminal amido group.