Claims
- 1. A method for inhibiting the growth of a human tumor comprising, administering to a human suspected of having the tumor an effective amount of an antisense oligonucleotide comprising from about 20 to 100 nucleotides comprising a sequence selected from the group consisting of SEQ ID NOs:17-31 in Table 2 under conditions such that the growth of the tumor is inhibited.
- 2. The method according to claim 1 wherein the oligonucleotide is nuclease resistant.
- 3. The method according to claim 1 further comprising the step of administering to the human a chemotherapeutic agent.
- 4. A method for inhibiting the metastasis of a human tumor comprising, administering to a human suspected of having a metastatic tumor an effective amount of an antisense oligonucleotide from about 20 to 100 nucleotides comprising a sequence complementary to the 5′ untranslated region consisting of exons 4, 5 or 6 of human fetal IGF-II mRNA under conditions such that metastasis of the tumor is inhibited.
- 5. The method according to claim 4 further comprising the step of administering to the human a chemotherapeutic agent.
- 6. The method according to claim 4 wherein the oligonucleotide is nuclease resistant.
- 7. The method according to claim 4 wherein the oligonucleotide comprises a sequence selected from the group consisting of SEQ ID NOs:1-15.
- 8. A method for inhibiting the metastasis of a human tumor comprising, administering to a human suspected of having a metastatic tumor an effective amount of an antisense oligonucleotide from about 20 to 100 nucleotides comprising a sequence selected from the group consisting of SEQ ID NOs:17-31 under conditions such that metastasis of the tumor is inhibited.
- 9. The method according to claim 8 further comprising the step of administering to the human a chemotherapeutic agent.
- 10. The method according to claim 9 wherein the oligonucleotide is nuclease resistant.
- 11. The method according to claim 4, wherein the antisense oligonucleotide comprises from about 20 to about 50 nucleotides.
REFERENCE TO RELATED APPLICATIONS
[0001] This application claims priority to U.S. Provisional Application Serial No. 60/082,791 filed Apr. 23, 1998, which application is incorporated herein by reference in its entirety.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60082791 |
Apr 1998 |
US |
Divisions (1)
|
Number |
Date |
Country |
Parent |
09295593 |
Apr 1999 |
US |
Child |
10125181 |
Apr 2002 |
US |