Ali et al. Neurobio. Of Aging, 17:223-234, 1996.* |
Kappel et al.; Regulating gene expression in transgenic animals, 1992, Current Opinion in Biotechnology 3: 548-553.* |
Strojek et al.; The Use of Transgenic Animal Techniques for Livestock Improvement, 1988, Genetic Engineering: Principles and Methods vol. 10:221-246.* |
Wall; Transgenic Livestock: Progress and Prospects for the Future, 1996, Theriogenology 45: 57-68.* |
Houdebine; Production of pharmaceutical proteins from transgenic animals, 1994, Journal of Biotechnology 34: 269-287.* |
Hammer et. al.; Genetic Engineering of Mammalian Embryos, 1986 J. Anim. Sci. 63: 269-278.* |
Ebert et. al.; A Moloney MLV-Rat Somatrotropin Fusion Gene Produces Biologically Active Somatotropin in a Transgenic Pig, 1988, Molecular Endocrinology:277-283.* |
Mullins et. al.; Perspective Series: Molecular Medicine in Genetically Engineered Animals, 1996, J. Clin. Invest. vol. 98, No. 11: S37-S40.* |
Stern, D., AM Schmidt and Jun Wu—A Method for Treating Symptoms Of Diabetes In A Subject (PCT/US97/21197, filed Nov. 12, 1997). |
Stern, D., Shi Du Yan, Ann Marie Schmidt—PCT International Application No. PCT/US98/21346; filed Oct. 9, 1998; Ligand Binding Site of RAGE. |
Stern, D., Yan, S-D. and Schmidt, A. M., U.S. patent application Ser. No. 09/374,213, filed Aug. 13, 1999, A Method of Preventing Amyloid Disturbance of Cellular Properties and for Clearing Amyloid from Tissue. |
Ghersi-Egea JF, Gorevic PD, Ghiso J, Frangione BF, Patlak CS, Fenstermacher JD. Fate of cerebrospinal fluid-borne amyloid β-peptide: rapid clearance into blood and appreciable accumulation by cerebral arteries J Neurochem 1996; 67:880-83. |
Hofmann MA, Drury S, Fu C, Qu W, Taguchi A, Lu Y, Avila C, Kambham N, Bierhaus A, Nawroth P, Neurath MF, Slattery T, Beach D, McClary J, Nagashima M, Morser J, Stern D, Schmidt AM. RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides. Cell 1999;97:889-901. |
Holtzman DM, Bales KR, Wu S, Bhat P, Parsadanian M, Fagan Am, Chang LK, Sun Y, Paul SM. In Vivo expression of apolipoprotein E Reduces amyloid-â-deposition in a mouse model of Alzheimer's Disease. J. Clin Invest 1999; 103:R15-21. |
Mackic JB, Weiss MH, Miao W, Ghiso J, Calero M, Bading J, Frangione B, Zlokovic BV. Cerebrovascular accumulation and increased blood-brain barrier permeability to circulationg Alzheimer's amyloid-β peptide in aged squirrel monkey with cerebral amyloid angiopathy. J Neurochem 1998; 70:210-5. |
Mackic JB, Stins M, McComb JG, Calero M, Ghiso J, Kim KS, Yan SD, Stern D, Schmidt AM, Frangione B, Zlokovic BV. Human blood-brain barrier receptors for Alzheimer's amyloid-β 1-40: asymmetrical binding, endocytosis and transcytosis at the apical side of brain microvascular endothelial cell monolayer. J Clin Invest 1998; 102:734-743. |
Neeper, M., et al. (1992). Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins. J. Biol. Chem. 267: 14998-15004. |
Poduslo JF, Curran GL, Haggard JJ, Biere AL, Selkoe DJ. Permeability and residual plasma volume of human, Dutch variant, and rat amyloid β-protein 1-40 at the blood-brain barrier. Neurobiol Dis 1997;4(1) :27-34. |
Schmidt, A-M, et al. (1992) “Isolation and characterization of binding proteins for advanced glycation endproducts from lung tissue which are present on the endothelial cell surface” J. Biol. Chem., 267:14987-14997. |
Schmidt AM, Hasu M, Popov D, Zhang JH, Chen J, Yan SD, Brett J, Cao R, Kuwabara K, Gostache G, Simionescu N, Simionecu M, Stern D. Receptor for advanced glycation end products (AGE) has a central role in vessel wall interactions and gene activation in response to circulating AGE proteins. Proc Natl Acad Sci USA 1994;91:8807-11. |
Yan SD, Chen X, Fu J, Chen M, Zhu H, Roher A, Slattery T, Zhao L, Nagashima M, Morser J, Migheli A, Nawroth P, Stern D, Schmmidt AM. RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease. Nature 1996;382:685-91. |
Yan SD, Zhu H, Zhu A, Golabek A, Du H, Roher A, Yu J, Soto C, Schmidt AM, Stern D, Kindy M. Receptor-dependent cell stress and amyloid accumulation in systemic amyloidosis. Nat Med 2000;6:643-51. |
Zlokovic BV, et al. Clearance of amyloid-b-peptide from brain: transport or metabolism? Nature Med. 6(7), 718-719. |
Zlokovic BV. Cerebrovascular permeability to peptides: manipulations of transport systems at the blood-brain barrier. Pharm Res 1995; 12 (10); 1395-1406. |