Ahmed, BioEssays, 6(4):175-177 "Structure and Function of Chimaeric Antibodies". |
Alegre et al., J. Immunol., 148(11):3461-3468 (1992) "Effect of a Single Amino Acid Mutation on the Activating and Immunosuppressive Properties of a Humanized OKT3 Monoclonal Antibody". |
Antin, et al., Blood, 78(8):2139-2149 (1991) "Selective Depletion of Bone Marrow T Lymphocytes With Anti-CD5 Monoclonal Antibodies: Effective Prophylaxis for Graft-Versus-Host Disease in Patients With Hematologic Malignancies". |
Barry, Dermatological Formulations p. 181 (1983) "Percutaneous Absorption". |
Better, et al., Science, 240:1041-1043 (1988) "Escherichia coli Secretion of an Active Chimeric Antibody Fragment". |
Better et al., J. Biol. Chem., 267(23): 16712-16718 (1992) "Activity of Recombinant Mitogillin and Mitogillin Immunoconjugates". |
Better et al., Proc Natl. Acad. Sci. USA, 90: 457-461 (1993) "Potent Anti-CD5 Ricin A Chain Immunoconjugates from Bacterially Produced Fab' and F(ab ')2". |
Bird et al., Science, 242: 423-426 (1988) "Single-Chain Antigen-Binding Proteins". |
Bolt et al., Eur. J. Immunol, 23(2): 403-411 (1993) "The Generation of Humanized, Non-Mitogenic CD3 Monoclonal Antibody Which Retains In Vitro Immunosuppressive Properties". |
Borrebaeck et al., Bio/Technology, "Kinetic Analysis of Recombinant Antibody-Antigen Interactions: Relation Between Structural Domains and Antigen Binding". |
Boulianne et al., Nature, 312: 643-646 (1984) "Production of Functional Chimeric Mouse/Human Antibody". |
Brady et al., J. Mol. Biol., 227:253-264 (1992) "Crystal Structure of a Chimeric Fab' Fragment of an Antibody Binding Tumour Cells". |
Brown et al., Proc. Natl. Acad. Sci. USA, 88: 2663-2667 (1991) "Anti-Tac-H, a Humanized Antibody To The Interleukin 2 Receptor, Prolongs Primate Cardiac Allograft Survival". |
Bruggemann et al., J. Exp. Med., 170: 2153-2157 (1989) "The Immunogenicity of Chimeric Antibodies". |
Buchner et al., Biotechnology, 9: 157-162 (1991) "Renaturation, Purification and Characterization of Recombinant F.sub.ab -Fragments Produced in Escherichia coli". |
Byers et al., Blood, 75(7): 1426-1432 (1990) "Use of An Anti-Pan T-Lymphocyte Ricin A Chain Immunotoxin in Steroid-Resistant Acute Graft-Versus-Host Disease". |
Caron et al., Cancer Res., 52(24): 6761-6767 (1992) "Biological and Immunological Features of Humanized M195 (Anti-CD33) Monoclonal Antibodies". |
Carter et al., Proc. Natl. Acad. Sci. USA, 89: 4285-4289 (1992) "Humanization of Anti-p185.sup.HER2 Antibody for Human Cancer Therapy". |
Case et al., Proc. Natl. Acad. Sci. USA, 86: 287-291 (1989) "Chimeric Cytotoxin IL2-PE40 Delays and Mitigates Adjuvant-Induced Arthritis in Rats". |
Cheadle et al., Mol. Immunol., 29: 21-30 (1992) "Cloning and Expression of the Variable Regions of Mouse Myeloma Protein MOPC315 in E. coli:Recovery of Active F.sub.x Fragments". |
Chothia et al., The EMBO Journal, 7(12): 3745-3755 (1988) "The Outline Structure of the T-Cell .alpha..beta. Receptor". |
Chothia et al., J. Mol. Biol., 196: 901-917 (1987) "Canonical Structures for the Hypervariable Regions of Immunoglobulins". |
Chothia et al., Nature, 342: 877-883 (1989) "Conformations of Immunoglobulin Hypervariable Regions". |
Chothia et al., J. Mol. Biol., 186: 651-663 (1985) "Domain Association in Immunoglobulin Molecules, The Packing of Variable Domains". |
Chothia and Lesk, Cold Spring Harbor Symp. Quant. Biol., 52: 399-405 (1987) "The Evolution of Protein Structures". |
Choy et al., Scandinavian J. Immunol., 36: 291-298 (1992) "Treatment of Rheumatoid Arthritis With Single Dose or Weekly Pulses of Chimaeric Anti-CD4 Monoclonal Antibody". |
Co et al., Nature, 351: 501-502 (1991) "Humanized Antibodies for Therapy". |
Co et al., Proc. Natl. Acad. Sci. USA, 88: 2869-2873 (1991) "Humanized Antibodies for Antiviral Therapy". |
Co et al., J. Immunol., 148: 1149-1154 (1992) "Chimeric and Humanized Antibodies with Specificity for the CD33 Antigen". |
Daugherty, et al., Nucleic Acids Res., 19: 2471-2476 (1991) "Polymerase Chain Reaction Facilitates the Cloning, CDR-grafting, and Rapid Expression of a Murine Monoclonal Antibody Directed Against the CD18 Component of Leukocyte Integrins". |
Davies & Metzger, Ann. Rev. Immunol., 1: 87-117 (1983) "Structural Basis of Antibody Function". |
Davies and Padlan, Ann. Rev. Biochem., 59: 439-473 (1990) "Antibody-Antigen Complexes". |
Derocq et al., Transplantation, 44(6): 763-769 (1987) "Rationale for the Selection of Ricin A-Chain Anti-T Immunotoxins for Mature T Cell Depletion". |
Eigenbrot et al., J. Mol. Biol., 229: 969-995 (1993) "X-ray Structures of the Antigen-binding Domains from Three Variants of Humanized Anti-p185.sup.HER3 Antibody 4D5 and Comparison with Molecular Modeling". |
Ey et al., Immunochem., 15: 429-436 (1978) "Isolation of pure IgG.sub.1, IgG.sub.2a and IgG.sub.2b Immunoglobulins from Mouse Serum Using Protein A-Sepharose". |
Fishwild et al., Clin. Exp. Immunol., 86: 506-513 (1991) "Cytotoxicity Against Human Peripheral Blood Mononuclear Cells and T Cell Lines Mediated By Anti-T Cell Immunotoxins in the Absence of Added Potentiator". |
Fishwild et al., Clin. Exp. Immunol., 97: 10-18 (1994) "Characterization of the Increased Cytotoxicity of Gelonin Anti-T Cell Immunoconjugates Compared with Ricin A Chain Immunoconjugates". |
Foote et al., J. Mol. Biol., 224: 487-499 (1992) "Antibody Framework Residues Affecting the Conformation of Hypervariable Loops". |
Galfre et al., Nature, 266: 550-552 (1977) "Antibodies to Major Histocompatibility Antigens Produced by Hybrid Cell Lines". |
Glaser et al., J. Immunol., 149(8): 2607-2614 (1992) "Dissection of the Combining Site in a Humanized Anti-Tac Antibody". |
Glockshuber et al., Biochemistry, 18: 1362-1367 (1990) "A Comparison of Strategies to Stabilize Immunoglobulin F.sub.V -Fragments". |
Goff et al., Bioconjugate Chem., 1: 381-386 (1990) "Substituted 2-Iminothiolanes: Reagents for the Preparation of Disulfide Cross-Linked Conjugates With Increased Stability". |
Goldberg et al., J. Autoimmunity, 4: 617-630 (1991) "Immunological Effects of High Dose Administration of Anti-CD4 Antibody In Rheumatoid Arthritis Patients". |
Goldberg et al., Arthritis and Rheumatism, 33: S153, Abstract D115 (1990) "Preliminary Trial of an Anti-CD4 Monoclonal Antibody (MoAb) in Rheumatoid Arthritis (RA)". |
Gorman et al., Proc. Natl. Acad. Sci. USA, 88: 4181-4185 (1991) "Reshaping a Therapeutic CD4 Antibody". |
Hafler et al., Neurology, 36: 777-784 (1986) "Immunologic Responses of Progressive Multiple Sclerosis Patients Treated With An Anti-T-Cell Monoclonal Antibody, Anti-T12". |
Hakimi et al., J. Immunol., 147: 1352-1359 (1991) "Reduced Immunogenicity and Improved Pharmacokinetics of Humanized Anti-Tac in Cynomolgus Monkeys". |
Hakimi et al., J. Immunol., 151: 1075 (1993) "Humanized Mik.beta.1, A Humanized Antibody to the IL-2 Receptor .beta.-chain That Acts Synergistically With Humanized Anti-TAC". |
Hale et al., The Lancet, 11: 1394-1399 (1988) "Remission Induction in Non-Hodgkin Lymphoma With Reshaped Human Monoclonal Antibody Campath-1H". |
Hara et al., Clinical Immunology and Immunopathology, 49: 223-230 (1988) "Stimulatory Effect of CD5 Antibody on B Cells from Patients With Rheumatoid Arthritis". |
Harlow et al., Eds., Antibodies: A Laboratory Manual, Chapter 14, "Immunoassays", Cold Spring Harbor Laboratory, Cold Spring Harbor (1988). |
Hodgson, Biotechnology, 8: 1245-1247 (1990) "Protein Design: Rules, Empiricism, & Nature". |
Horneff et al., Arthritis and Rheumatism, 34(2): 129-140 (1991) "Treatment of Rheumatoid Arthritis With An Anti-CD4 Monoclonal Antibody". |
Hsiao et al., Antibody Engineering Meeting, Dec. 14-16, 1992, Abstract "Humanization of Anti-CD18 mAb 60.3". |
Huse et al., Science, 246: 1275-1281 (1989) "Generation of a Large Combinatorial Library of the Immunoglobulin Repertoire in Phage Lambda". |
Huston et al., Proc. Natl. Acad. Sci. USA, 85: 5879-5883 (1988) "Protein Engineering of Antibody Binding Sites: Recovery of Specific Activity in an Anti-Digoxin Single-Chain Fv Analogue Produced in Escherichia coli". |
Janin et al., J. Biol. Chem., 265: 16027-16030 (1990) "The Structure of Protein-Protein Recognition Sites". |
Jones et al., Biotechnology, 9: 88-89 (1991) "Rapid PCR Cloning of Full-Length Mouse Immunoglobulin Variable Regions". |
Jones et al., Nature, 321: 522-525 (1986) "Replacing the Complementarity-Determining Regions in a Human Antibody with those from a Mouse". |
Junghans et al., Cancer Res., 50 (5): 1495-1502 (1990) "Anti-Tac-H, A Humanized Antibody to the Interleukin 2 Receptor with New Features for Immunotherapy in Malignant and Immune Disorders". |
Kabat et al., J. Biol. Chem., 252 (19): 6609-6616 (1977) "Unusual Distributions of Amino Acids in Complementarity-Determining (Hypervariable) Segments of Heavy and Light Chains of Immunoglobulins and their Possible Roles in Specificity of Antibody-Combining Sites". |
Kelley et al., Biochem., 32: 6828-6835 (1993) "Thermodynamic Analysis of an Antibody Functional Epitope". |
Kelley et al., Biochem., 31: 5434-5441 (1992) "Antigen Binding Thermodynamics and Antiproliferative Effects of Chimeric and Humanized Anti-p185.sup.HER2 Antibody Fab Fragments". |
Kernan et al., J. Immunol., 133 (1): 137-146 (1984) Specific Inhibition of in vitro Lymphocyte Transformation by an Anti-Pan T Cell (gp67) Ricin A Chain Immunotoxin. |
Kettleborough et al., Protein Engineering, 4: 773-783 (1991) "Humanization of a Mouse Monoclonal Antibody by CDR-Grafting: The Importance of Framework Residues on Loop Conformation". |
Kirkham et al., Brit. J. Rheumatology, 30: 88 Abstract 16 (1991) "Chimaeric (Human/Mouse) CD7 Monoclonal Antibody Treatment in Rheumatoid Arthritis". |
Kirkham et al., Brit. J. Rheumatology, 30: 459-463 (1991) "Monoclonal Antibody Treatment in Rheumatoid Arthritis: The Clinical and Immunological Effects of a CD7 Monoclonal Antibody". |
Kirkham et al., J. Rheumatology, 19: 1348-1352 (1992) "Chimeric CD7 Monoclonal Antibody Therapy in Rheumatoid Arthritis". |
Knowles, Chapter 22 in Reinherz et al., Leukocyte Typing II, 1: 259-288 (Springer-Verlag, 1986) "Immunochemical Analysis of the T-Cell Specific Antigens". |
Koda et al., Hum. Antibody Hybridomas 1(1): 15-22 (1990) Review "In Vitro Immunization for the Production of Human Monoclonal Antibody". |
Kohler et al., Eur. J. Immunol., 6: 292-295 (1976) "Fusion Between Immunoglobulin-Secreting and Nonsecreting Myeloma Cell Lines". |
Kyle et al., J. Rheumatol., 18: 1737-1738 "Humanized Monoclonal Antibody Treatment in Rheumatoid Arthritis". 1991. |
Lambert et al., J. Biol. Chem., 246: 12035-12041 (1985) "Purified Immunotoxins that are Reactive with Human Lymphoid Cells". |
Laurent et al., Bone Marrow Transplantation. 4: 367-371 (1989) "Donor Bone Marrow Treatment With T101 Fab Fragment-Ricin A-Chain Immunotoxin Prevents Graft-Versus-Host Disease". |
Lazarovits et al., J. Immunol., 150(11): 5163-5174 (1993) "Human Mouse Chimeric CD7 Monoclonal Antibody (SDZCHH380) for the Prophylaxis of Kidney Transplant Rejection". |
Lesk et al., Nature, 335: 188-190 (1988) "Elbow Motion in the Immunoglobulins Involves a Molecular Ball-and socket Joint". |
Liu et al., Gene, 54: 33-40 (1987) "Expression of Mouse: Human Immunoglobulin Heavy-Chain cDNA in Lymphoid Cells". |
LoBuglio et al., Proc. Natl. Acad. Sci. USA, 86: 4220-4224 (1989) "Mouse/Human Chimeric Monoclonal Antibody in Man: Kinetics and Immune Response". |
Marks et al., J. Mol. Biol., 222: 581-597 (1991) "By-Passing Immunization: Human Antibodies from V-Gene Libraries Displayed on Phage". |
Marks et al., J. Biol. Chem., 267(23): 16007-16010 (1992) "Molecular Evolution of Proteins on Filamentous Phage". |
Martin et al., Proc. Natl. Acad. Sci. USA, 86: 9268-9272 (1989) "Modeling Antibody Hypervariable Loops: A Combined Algorithm". |
Mathieson et al., New England J. Med., 323 (4): 250-254 (1990) "Monoclonal-Antibody Therapy in Systemic Vasculitis". |
McCafferty et al., Nature, 348: 552-554 (1990) "Phage Antibodies: Filamentous Phage Displaying Antibody Variable Domains". |
Miglietta, et al., Antibody Engineering Meeting, Dec. 14-16, 1992 Abstract "Alteration of Framework Residues Modulate Binding of a CDR-Grafted Anti-Human ICAM-1". |
Morrison, Science, 229: 1202-1207 (1985) "Transfectomas Provide Novel Chimeric Antibodies". |
Morrison et al., Adv. in Immunol., 44: 65-92 (1989) "Genetically Engineered Antibody Molecules". |
Morrison et al., Proc. Natl. Acad. Sci., 81: 6851-6855 (1984) "Chimeric Human Antibody Molecules: Mouse Antigen-Binding Domains With Human Constant Region Domains". |
Munson et al., Anal Biochem., 107: 220-239 (1980) "LIGAND: A Versatile Computerized Approach for Characterization of Ligand-Binding Systems". |
Near et al., J. Immunol., 146 (2): 627-633 (1991) "The Specificity Properties that Distinguish Members of a Set of Homologous Anti-Digoxin Antibodies are Controlled by H Chain Mutations". |
Nishimura et al., Eur. J. Immunol., 18: 747-753 (1988) "Expression and Function of a CD5 cDNA in Human and Murine T Cells". |
Nisonoff et al., Archives of Biochem., 93 460-462 (1961) "Recombination of a Mixture of Univalent Antibody Fragments of Different Specificity". |
Novotny et al., Proc. Natl. Acad. Sci. USA, 82: 4592-4596 (1985) "Structural Invariants of Antigen Binding: Comparison of Immunoglobulin V.sub.L -V.sub.H and V.sub.L -V.sub.L Domain Dimers". |
Novotny et al., J. Mol. Biol., 189: 715-721 (1986) "Location of Antigenic Epitopes on Antibody Molecules". |
Novotny et al., Proc. Natl. Acad. Sci. USA, 83: 226-230 (1986) "Antigenic Determinants in Proteins Coincide with Surface Regions Accessible to Large Probes (Antibody Domains)". |
Novotny et al., Proc. Natl. Acad. Sci. USA, 83: 742-746 (1986) "Secondary, Tertiary, and Quaternary structure of T-cell-specific Immunoglobulin-like Polypeptide Chains". |
Padlan et al., Proc. Natl. Acad. Sci. USA, 86: 5938-5942 (1989) "Structure of an Antibody-Antigen Complex: Crystal Structure of the HyHEL-10 Fab-Lysozyme Complex". |
Padlan, E.A. Molecular Immunology, 28(4/5): 489-498 (1991) "A Possible Procedure For Reducing The Immunogenicity of Antibody Variable Domains While Preserving Their Ligand-Binding Properties". |
Peacock et al., Arthritis and Rheumatology, 35 (Suppl.) Abstract No. B141 (1992) "An Angiogenesis Inhibitor in Combination with Anti-CD5 Mab Suppresses Established Collagen Induced Arthritis Significantly More Than Single Agent Therapy". |
Pluckthun, Biotechnology, 9: 545-551 (1991) "Antibody Engineering: Advances From The Use of Escherichia coli Expression Systems". |
Potter et al., Proc. Natl. Acad. Sci. USA, 81: 7161-7165 (1984) "Enhancer-dependent Expression of Human K Immunoglobulin Genes Introduced into Mouse pre-B Lymphocytes by Electroporation". |
Presta et al., J. Immunol, 151: 2623-2632 (1993) "Humanization of an Antibody Directed Against IgE". |
Queen et al., Proc. Natl. Acad. Sci. USA, 86: 10029-10033 (1989) "A Humanized Antibody that Binds to the Interleukin 2 Receptor". |
Racadot et al., Brit. J. Rheumatology, 30: 88 (1991) Abstract "Immunological Follow Up of 13 Patients With Rheumatoid Arthritis Treated by Anti-T CD4+ Monoclonal Antibodies". |
Riechmann et al., Nature, 332: 323-327 (1988) "Reshaping Human Antibodies for Therapy". |
Roberts et al., Nature, 328: 731-734 (1987) "Generation of an Antibody with Enhanced Affinity and Specificity for Its Antigen by Protein Engineering". |
Robinson et al., Hum. Antib. Hybridomas, 2: 84-93 (1991) "Chimeric Mouse-Human Anti-Carcinoma Antibodies that Mediate Different Anti-Tumor Cell Biological Activities". |
Rodwell, Nature, 342: 99-100 (1989) "Engineering Monoclonal Antibodies". |
Roguska et al., Proc. Natl. Acad. Sci. USA, 91: 969-973 (1994) "Humanization of Murine Monoclonal Antibodies Through Variable Domain Resurfacing". |
Rostaing-Capaillon et al., Cancer Immunol. Immunother., 34: 24-30 (1991) "In Vivo Cytotoxic Efficacy of Immunotoxins Prepared From Anti-CD5 Antibody Linked to Ricin A-Chain". |
Routledge et al., Eur. J. Immunol., 21: 2717-2725 (1991) "A Humanized Monovalent CD3 Antibody which can Activate Homologous Complement". |
Royston et al., J. Immunol. 125(2): 725-731 (1980) "Human T Cell Antigens Defined By Monoclonal Antibodies: The 65,000-Dalton Antigen of T Cells (T65) Is Also Found On Chronic Lymphocytic Leukemia Cells Bearing Surface Immunoglobulin". |
Schlom, J. Molecular Foundations of Oncology, Samuel Broder (Ed.), Williams and Wilkins, Baltimore, MD Chapter 6 pp. 95-134 "Monoclonal Antibodies: They're More And Less Than You Think". |
Sharon et al., Nature, 309: 364-367 (1984) "Expression of a V.sub.H C.sub.K Chimaeric Protein in Mouse Myeloma Cells". |
Shearman et al., Antibody Engineering Meeting, Dec. 10-11, 1990 Abstract "Humanized Antibodies with Specificity for the Human .alpha./.beta. T Cell Receptor". |
Shearman et al., J. Immunol., 147(12): 4366-4373 (1991) "Construction, Expression and Characterization of Humanized Antibodies Directed Against the Human .alpha./.beta. Cell Receptor". |
Sims et al., J. Immunol., 151(4): 2296-2308 (1993) "A Humanized CD18 Antibody can Block Function Without Cell Destruction". |
Singer et al., J. Immunol., 150: 2844-2857 (1993) "Optimal Humanization of 1B4, An Anti-CD18 Murine Monoclonal Antibody, Is Achieved by Correct Choice of Human V-Region Framework Sequences". |
Skerra et al., Science, 1038-1041 (1988) "Assembly of a Functional Immunoglobulin F.sub.V Fragment in Escherichia coli". |
Strand et al., Arthritis and Rheumatism, 33 (9 Suppl.) (1990) p. S25 "Treatment of Rheumatoid Arthritis With An Anti-CD5 Immunoconjugate: Clinical And Immunologic Findings and Preliminary Results of Re-Treatment". |
Studnicka, G.M., Biochem J., 252: 825-831 (1988) "Escherichia coli Promoter -10 and -35 Region Homologies Correlate with Binding and Isomerization Kinetics". |
Takeda et al., Nature, 314: 452-454 (1985) "Construction of Chimaeric Processed Immunoglobulin Genes Containing Mouse Variable and Human Constant Region Sequences". |
Tempest et al., Biotechnology, 9: 266-271 (1991) "Reshaping a Human Monoclonal Antibody to Inhibit Human Respiratory Syncytial Virus Infection in vivo". |
Thornton, Nature, 343: 411-412 (1990) "Tackling a Loopy Problem". |
Tramontano et al., J. Mol. Biol., 215: 175-182 (1990) "Framework Residue 71 is a Major Determinant of the Position and Conformation of the Second Hypervariable Region in the V.sub.H Domains of Immunoglobulins". |
Tramontano et al., Proteins: Function and Genetics, 6: 382-394 (1989) "Structural Determinants of the Conformations of Medium-Sized Loops in Proteins". |
Verhoeyen et al., Science, 239: 1534-1536 (1988) "Reshaping Human Antibodies: Grafting an Antilysozyme Activity". |
Verhoeyen et al., BioEssays, 8(2): 74-78 (1988) "Engineering of Antibodies". |
Vitetta et al., Science, 238: 1098-1104 (1987) "Redesigning Nature's Poisons to Create Anti-Tumor Reagents". |
Ward et al., Nature, 341: 544-546 (1989) "Binding Activities of a Repertoire of Single Immunoglobulin Variable Domains Secreted from Escherichia coli". |
Winter et al., Nature, 349: 293-299 (1991) "Man-Made Antibodies". |
Wofsky et al., J. Immun., 134(2): 852-857 (1985) "Treatment of Murine Lupus with Monoclonal Anti-T Cell Antibody". |
Woodle et al., J. Immunol., 148: 2756-2763 (1992) "Humanized OKT3 Antibodies: Successful Transfer of Immune Modulating Properties and Idiotype Expression". |
Wu et al., J. Exp. Med., 132: 211-250 (1970) "An Analysis of the Sequences of the Variable Regions of Bence Jones Proteins and Myeloma Light Chains and Their Implications for Antibody Complementarity". |
Wu and Kabat., Mol. Immunol., 29(9): 1141-1146 (1992) "Possible Use of Similar Framework Region Amino Acid Sequences Between Human and Mouse Immunoglobulins for Humanizing Mouse Antibodies". |