Benowitz, L.I. and Lewis, E.R., "Increased Transport of 44,000- to 49,000-Dalton Acidic Proteins During Regeneration of the Goldfish Optic Nerve: A Two-Dimensional Gel Analysis," J. Neurosci. 3(11):2153-2163 (1983). |
de la Monte, S.M. and Wands, J.R. "Neuronal thread protein over-expression in brains with Alzheimer's disease lesions," J. Neurol. Sci. 113:152-164 (Dec. 1992). |
de la Monte et al., "Enhanced Expression of an Exocrine Pancreatic Protein in Alzheimer's Disease and the Developing Human Brain," J. Clin. Invest. 86:1004-1013 (1990). |
de la Monte et al., "Increased Levels of Neuronal Thread Protein in Cerebrospinal Fluid of Patients with Alzheimer's Disease," Ann. Neurol. 32:733-742 (June 1992). |
De Caro et al., "Characterization of a Protein Isolated From Pancreatic Calculi of Men Sufferng From Chronic Calcifying Pancreatitis," Biochem. Biophys. Res. Comm. 87(4) :1176-1182 (1979). |
De Caro et al., "Complete amino acid sequence of an immunoreactive form of human pancreatic stone protein isolated from pancreatic juice," Eur. J. Biochem. 168:201-207 (1987). |
De Caro et al., "The molecular characteristics of a human pancreatic acidic phosphoprotein that inhibits calcium carbonate crystal growth," Biochem. J. 222:669-677 (1984). |
De Graan et al., "Phosphoprotein B-50 in Nerve Growth Cones from Fetal Rat Brain," Neurosci Lett. 61:235-241 (1985). |
DePamphilis, M.L., "Origins of DNA Replication in Metazoan Chromosomes," J. Biol. Chem. 268(1):1-4 (Jan. 1993). |
European Search Report for European Patent Publication No. 0 378 924, Nov. 6, 1991. |
Forstner et al., "Selective Precipitation of 14 kDa Stone/Thread Proteins by Concentration of Pancreaticobiliary Secretions: Relevance to Pancreatic Ductal Obstruction, Pancreatic Failure, and CF," J. Pediatric Gastroenterology and Nutrition 8:313-320 (1989). |
Gross et al., "Isolation, Characterization, and Distribution of an Unusual Pancreatic Human Secretory Protein," J. Clin. Invest. 76:2115-2126 (1985). |
Gross et al., "An unusual bovine pancreatic protein exhibiting pH-dependent globule-fibril transformation and unique amino acid sequence," PNAS USA 82:5627-5631 (1985). |
Guy-Crotte et al., "Characterization and N-Terminal Sequence of a Degradation Product of 14,000 Molecular Weight Isolated From Human Pancreatic Juice," Biochem. Biophys. Res. Comm. 125(2) :516-623 (1984). |
Ishii et al., "Presence of Neurofilament Protein in Alzheimer's Neurofibrillary Tangles (ANT), An Immunofluorescent Study," Acta Neuropathol. (Berl.) 48:105-112 (1979). |
Kalil, K. and Skene, J.H.P., "Elevated Synthesis of an Axonally Transported Protein Correlates with Axon Outgrowth in Normal and Injured Pyramidal Tracts," J. Neurosci. 6(9):2563-2570 (1986). |
Lasserre et al., "A Novel Gene (HIP) Activated in Human Primary Liver Cancer," Cancer Res. 52:5089-5095 (Sep. 1992). |
Lathe, R., "Synthetic Oligonucleotide Probes Deduced from Amino Acid Sequence Data, Theoretical and Practical Considerations," J. Molec. Biol. 183:1-12 (1985). |
Ozturk et al., "Elevated levels of an exocrine pancreatic secretory protein in Alzheimer disease brain," PNAS USA 86:419-423 (1989). |
Perry et al., "Alteration of the Neurofilament--Microtubule Network in Alzheimer Disease and Other Neurogenerative Disorders," in: Alterations of the Neuronal Cytoskeleton in Alzheimer's Disease, Plenum Press, pp. 137-149 (1987). |
Sano et al., "Immuno-PCR: Very Sensitive Antigen Detection by Means of Specific Antibody-DNA Conjugates," Science 258:120-122 (Oct. 1992). |
Sano et al., "A Streptavidin-Protein A Chimera That Allows One-Step Production of a Variety of Specific Antibody Conjugates," Bio/Technology 9:1378-1381 (1991). |
Selkoe, D.J., "Altered Structural Proteins in Plaques and Tangles: What Do They Tell Us About the Biology of Alzheimer's Disease?" Neurobiology of Aging 7:425-432 (1986). |
Terazono et al., "A Novel Gene Activated in Regenerating Islets," J. Biol. Chem. 263(5) :2111-2114 (1988). |
Watanabe et al., "Complete Nucleotide Sequence of Human reg Gene and Its Expression in Normal and Tumoral Tissues," J. Biol. Chem. 265(13) :7432-7439 (1990). |
Wischik et al., "Structural Characterization of the Core of the Paired Helical Filament of Alzheimer Disease," PNAS USA 85:4884-4888 (1988). |
Wolozin et al., "A Neuronal Antigen in the Brains of Alzheimer Patients," Science 232:648-650 (1986). |
Gutierrez et al., "Gene therapy for cancer," The Lancet 339:715-721 (Mar. 1992). |
Abraham, C.R. et al., "Immunochemical Identification of the Serine Protease Inhibitor .alpha..sub.1 -Antichymotrypsin in the Brain Amyloid Deposits of Alzheimer's Disease," Cell 52:487-501 (Feb. 1988). |
de la Monte, S.M. and J.R. Wands, "Neuronal Thread Protein: A Potential Marker for Alzheimer's Disease," J. Neuropathol. Exp. Neurol. 50:316, Abstract No. 83 (May 1991). |
de la Monte, S.M. and J.R. Wands, "Elevated Neuronal Thread Protein Levels in Ventricular Fluid and Temporal Cortex of Alzheimer's Disease," Neurobiol Aging 13, Suppl. 1:s26, Abstract No. 103 (1992). |
Figarella, C. et al., "Pancreatic Stone Protein, Protein X, and Thread Protein," Lancet 1(8526):222-223 (Jan. 1987). |
Glenner, G.G. et al., "Alzheimer's Disease: Initial Report of the Purification and Characterization of a Novel Cerebrovascular Amyloid Protein," Biochem. Biophys. Res. Comm. 120(3):885-890 (May 1984). |
Goldgaber, D. et al., "Characterization and Chromosomal Localization of a cDNA Encoding Brain Amyloid of Alzheimer's Disease," Science 235:877-880 (Feb. 1987). |
Chong, J.K. et al., "Automated Microparticle Enzyme Immunoassay for Neural Thread Protein in Cerebrospinal Fluid from Alzheimer's Disease Patients," J. Clin. Lab. Anal. 6:379-383 (1992). |
Ghanbari, H. et al., "Detection and Measurement of Alzheimer's Disease Associated Protein (ADAP) in Cerebrospinal Fluid (CSF): An Antemortem Marker for Alzheimer's Disease," Soc. Neurosci. 17--Abstracts from the 21st Annual Meeting:1259, Abstract No. 498.8 (1991). |
St. George-Hyslop, P.H. et al., "The Genetic Defect Causing Familial Alzheimer's Disease Maps on Chromosome 21," Science 235:885-890 (Feb. 1987). |
Tanzi, R.E. et al., "Amyloid .beta. Protein Gene: cDNA, mRNA Distribution, and Genetic Linkage Near the Alzheimer Locus," Science 258:880-884 (Feb. 1987). |
Van Broeckhoven, C. et al., "Failure of familial Alzheimer's disease to segregate with the A4-amyloid gene in several European families," Nature 329:153-155 (Sep. 1987). |
Joachim, C.L. et al., "Amyloid .beta.-protein deposition in tissues other than brain in Alzheimer's disease," Nature 341:226-230 (Sep. 1989). |
Johnson, S.A. et al., "Relation of Neuronal APP-751/APP-695 mRNA Ratio and Neuritic Plaque Density in Alzheimer's Disease," Science 248:854-857 (May 1990). |
Kang, J. et al., "The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor," Nature 325:733-736 (Feb. 1987). |
Manetto, V. et al., "Ubiquitin is associated with abnormal cytoplasmic filaments characteristic of neurodegenerative diseases," Proc. Natl. Acad. Sci. USA 85:4501-4505 (Jun. 1988). |
Masters, C.L. et al., "Amyloid plaque core protein in Alzhemier disease and Down syndrome," Proc. Natl. Acad. Sci. USA 82:4245-4249 (Jun. 1985). |
Schmiegel, W.-H. et al., "Pancreatic Stone Protein in Serum of Patients with Pancreatitis," Lancet 2(8508):686-687 (Sep. 1986). |
Abe, M., et al., "Production and Immunodiagnostic Applications of Antihuman Light Chain Monoclonal Antibodies," Am J. Clin. Pathol. 100:67-74 (Jul. 1993). |
Bahmanyar, S., et al., "Localization of Amyloid .beta. Protein Messenger RNA in Brains from Pathent with Alzheimer's Disease," Science 237:77-80 (Jul. 3, 1987). |
Denman, R.B., et al., "Ribozyme Mediated Degradation of .beta.-amyloid Peptide Precursor mRNA in COS-7 Cells," Nucl. Acids Res. 22(12):2375-2382 (Jun. 25, 1994). |
Ponte, P., et al., "A New A4 Amyloid mRNA Contains a Domain Homologous to Serine Proteinase Inhibitors," Nature 331:525-527 (Feb. 11, 1988). |
A copy of the International Search Report for the correspnding PCT application, International Application No. PCT/US95/17111, 1996. |
Chong, J. et al., "Detection and Measurement of Neural Thread Protein (NTP) in Cerebrospinal Fluid (CSF): A Potential Antemortem Marker for Alzheimer's Disease," Soc. Neurosci. 17--Abstracts from the 21st Annual Meeting:1259, Abstract No. 498.7 (1991). |
Wischik, C.M. et al., "Structural characterization of the core of the paired helical filament of Alzheimer disease," Proc. Natl. Acad. Sci. USA 85:4884-4888 (Jul. 1988). |
Abraham et al. (Feb., 1988) Cell, vol. 52, pp. 487-501, 1988. |
Studier et al., 185 Meth. Enz. 60-89 (David V. Goeddel, ed. 1990). |
Tsuji et al., 11 EMBO J. 4843-50 (1992). |