Claims
- 1. A compound of the formula: ##STR525## wherein at each occurrence R.sub.3 is independently selected from the group consisting of
- (i) C.sub.1 -to-C.sub.6 -loweralkyl,
- (ii) aryl,
- (iii) (aryl)-C.sub.1 -to-C.sub.6 -alkyl,
- (iv) C.sub.3 -to-C.sub.7 -cycloalkyl and
- (v) C.sub.3 -to-C.sub.7 -cycloalkyl-C.sub.1 -to-C.sub.6 -alkyl
- R.sub.9 is independently selected at each occurrence from the group consisting of hydrogen and aryl-C.sub.1 -to-C.sub.6 -alkyl;
- R.sub.17 at each occurrence is independently selected from the group consisting of C.sub.1 -to-C.sub.6 -loweralkyl, aryl and aryl-C.sub.1 -to-C.sub.6 -alkyl;
- R.sub.800 is --O--;
- and at each occurrence h is independently selected from the group consisting of 0 and 1;
- wherein at each occurrence aryl is independently selected from phenyl, naphthyl, tetrahydronaphthyl, indanyl, tetrafluorophenyl and pentafluorophenyl and wherein the phenyl, naphthyl, tetrahydronaphthyl and indanyl rings are unsubstituted or substituted with one, two or three substitutents independently selected from the group consisting of C.sub.1 -to-C.sub.6 -loweralkyl, halo-C.sub.1 -to-C.sub.6 -alkyl, C.sub.1 -to-C.sub.6 -alkoxy, C.sub.1 -to-C.sub.6 -thioalkoxy, amino, C.sub.1 -to-C.sub.6 -alkylamino, di-C.sub.1 -to-C.sub.6 -alkylamino, hydroxy, halo, mercapto, nitro, carboxaldehyde, carboxy, carbo-C.sub.1 -to-C.sub.6 -alkoxy and carboxamide;
- or a pharmaceutically acceptable salt thereof.
- 2. A compound according to claim 1 of the formula: ##STR526## wherein at each occurrence R.sub.3 is independently selected from the group consisting of
- C.sub.1 -to-C.sub.6 -loweralkyl, C.sub.3 -to-C.sub.7 -cycloalkyl, C.sub.3 -to-C.sub.7 -cycloalkyl-C.sub.1 -to-C.sub.6 -alkyl, aryl and aryl-C.sub.1 -to-C.sub.6 -alkyl;
- R.sub.9 is independently selected at each occurrence from the group consisting of hydrogen and aryl-C.sub.1 -to-C.sub.6 -alkyl;
- R.sub.17 at each occurrence is independently selected from the group consisting of C.sub.1 -to-C.sub.6 -loweralkyl, aryl and aryl-C.sub.1 -to-C.sub.6 -alkyl;
- R.sub.800 is --O--;
- and at each occurrence h is independently selected from the group consisting of 0 and 1;
- or a pharmaceutically acceptable salt thereof.
- 3. A compound according to claim 1 of the formula: ##STR527## wherein at each occurrence R.sub.3 is independently selected from the group consisting of
- aryl-C.sub.1 -to-C.sub.6 -alkyl;
- R.sub.9 is independently selected at each occurrence from the group consisting of hydrogen and aryl-C.sub.1 -to-C.sub.6 -alkyl;
- R.sub.17 at each occurrence is independently selected from the group consisting of C.sub.1 -to-C.sub.6 -loweralkyl, aryl and arylC.sub.1 -to-C.sub.6 -alkyl;
- R.sub.800 is --O--;
- and at each occurrence h is independently selected from the group consisting of 0 and 1;
- or a pharmaceutically acceptable salt thereof.
- 4. A compound selected from the group consisting of:
- 2-(N-benzyl-N-(benzyloxycarbonyl)amino)-5-(t-butyloxycarbonylamino)-1,6-diphenyl-3-hexene-3,4-oxide;
- 2-amino-5-(t-butyloxycarbonylamino)-1,6-diphenyl-3-hexene-3,4-oxide; and
- 2,5-di-(t-butyloxycarbonylamino)-1,6-diphenyl-3-hexene-3,4-oxide.
Parent Case Info
This is a division of U.S. patent application Ser. No. 08/358,648, filed Dec. 19, 1994, which is a continuation of U.S. patent application Ser. No. 08/164,979, filed Dec. 7, 1993, now abandoned which is a continuation of U.S. patent application Ser. No. 07/880,729, filed May 8, 1992, now abandoned which is a division of U.S. patent application Ser. No. 07/518,730, filed May 9, 1990, now U.S. Pat. No. 5,142,056 which is a continuation-in-part of U.S. patent application Ser. No. 07/456,124, filed Dec. 22, 1989, now abandoned which is a continuation-in-part of U.S. patent application Ser. No. 07/405,604, filed Sep. 8, 1989, now abandoned which is a continuation-in-part of U.S. patent application Ser. No. 355,945, filed May 23, 1989 now abandoned.
US Referenced Citations (2)
| Number |
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|
5142056 |
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Aug 1992 |
|
|
5354866 |
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Oct 1994 |
|
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Divisions (2)
|
Number |
Date |
Country |
| Parent |
358648 |
Dec 1994 |
|
| Parent |
518730 |
May 1990 |
|
Continuations (2)
|
Number |
Date |
Country |
| Parent |
164979 |
Feb 1993 |
|
| Parent |
880729 |
May 1992 |
|
Continuation in Parts (3)
|
Number |
Date |
Country |
| Parent |
456124 |
Dec 1989 |
|
| Parent |
405604 |
Sep 1989 |
|
| Parent |
355945 |
May 1989 |
|
Patent Grant
5670675
