Barinaga, Science 262:1512 (1993). |
Donahue et al. J.V.r. 62:722 (1988). |
Olmsted et al. PNAS 86:8088 (1989). |
Johnston et al. Science 260: 1286, (1993). |
Han et al. PNAS 88:4313 (1991). |
Aropulic et al. J.V.r. 66:1432 (1992). |
Ratner et al. Nature 313:277 (1985). |
Goodchild et al. NAR 20:4607 (1992). |
Lever et al. J.V.r. 63:4085 (1989). |
Mann et al. J. V.r. 54: 401 (1985). |
Stull et al. Pharm. Res. 12: 465 (1995). |
Berzal-Herranz, A. et al. (1993) "Essential Nucleotide Sequences and Secondary Structure Elements of the Hairpin Ribozyme," EMBO 12:2567-2674 (Exhibit 3). |
Bevec, D. et al. (1992) "Inhibition of Human Immunodeficiency Virus Type 1 Replication in Human T Cells by Retroviral-Mediated Gene Transfer of a Dominant-Negative Rev Trans-Activator," Proc. Natl. Acad. Sci. (USA) 89:9870-9874 (Exhibit 4). |
Bischofberger, N. and Wagner, R.W. (1992) "Antisense Approaches to Antiviral Agents," Virology 3:57-66 (Exhibit 5). |
Chen, C-J. et al. (1992) "Inhibition of HIV-1 Replication by Novel Multitarget Ribozymes," Ann. N.Y. Acad. Sci. (USA) 660:271-273 (Exhibit 6). |
Chen, C-J. et al. (1992) "Multitarget-Ribozyme Directed to Cleave at up to Nine Highly Conserved HIV-1 env RNA Regions Inhibits HIV-1 Replication-Potential Effectiveness Against Most Presently Sequenced HIV-1 Isolates," Nucleic Acids Res. (Eng.) 20:4581-4589 (Exhibit 7). |
Chowrira, B.M. et al. (1993) "Four Ribose 2'-Hydroxyl Groups Essential for Catalytic Function of the Hairpin Ribozyme," J.Biol.Chem. 268:19458-19462 (Exhibit 8). |
Cournoyer, D. and Caskey, C.T. (1993) "Gene Therapy of the Immune System, " Annu. Rev. Immunol. (USA) 11:297-329 (Exhibit 9). |
Crisell, P. et al. (1993) "Inhibition of HIV-1 Replication by Ribozymes that Show Poor Activity in vitro," Nucleic Acids Res. (Eng.) 21:5251-5255 (Exhibit 10). |
Dropulic, B. et al. (1993) "Ribozymes: Use As Anti-HIV Therapeutic Molecules," Antisense Res. Dev. (USA) 3:87-94 (Exhibit 11). |
Goodchild, J. (1991) "Antisense Antivirals," Antisense Res. Dev. (USA) 1: 361-364 (Exhibit 12). |
Heidenreich, O. and Eckstein, F. (1992) "Hammerhead Ribozyme-Mediated Cleavage of Long Terminal Repeat RNA of Human Immundeficiency Virus Type 1," J. Biol. Chem. (USA) 267:1904-1909 (Exhibit 13). |
Homann, M. et al. (1993) "Incorporation of the Catalytic Domain of a Hammerhead Ribozyme Into Antisense RNA Enhances Its Inhibitory Effect on the Replication of Human Immunodeficiency Virus Type 1," Nucleic Acids Res. (Eng.) 21:2809-2814 (Exhibit 14). |
Johnston, M.I. and Burke, J.M. (1993) "Present Status and Future Prospects for HIV Therapies," Science 260:1286-1293 (Exhibit 15). |
Joseph, S. et al. (1993) "Optimization of an Anti-Hairpiin Ribozyme by in Vitro Selection," J. Biol. Chem. (USA) 268:24515-24518 (Exhibit 16). |
Joseph,S. et al. (1993) "Substrate Selection Rules for the Hairpin Ribozyme Determined by in Vitro Selection, Mutation, and Analysis of Mismatched Substrates," Genes and Development 7:130-138 (Exhibit 17). |
Levy, J. (1993) "Pathogenesis of Human Immunodeficiency Virus Infection," Microbiol. Rev. 57:183-289 (Exhibit 18). |
Lisziewicz, J. et al. (1993) "Inhibition of Human Immunodeficiency Virus Type 1 Replication By Regulated Expression of a Polymeric Tat Activation Response RNA Decoy as a Strategy For Gene Therapy in AIDS," Proc. Natl. Acad. Sci. USA 90: 8000-8004 (Exhibit 19). |
Liu, J.et al. (1994) "Regulated Expression of a Dominant Negative Form of Rev Improves Resistance to HIV Replication in T Cells," Gene Therapy (Eng.) 1:32-37 (Exhibit 20). |
Lo, K.M. et al. (1992) "Inhibition of Replication of HIV-1 by Retroviral Vectors Expressing tat-Antisense and Anti-tat Ribozyme RNA," Virology (USA) 190:176-183 (Exhibit 21). |
Lori, F. et al. (1994) "Rapid Protection Against Human Immunodeficiency Virus Type 1 (HIV-1) Replication Mediated by High Efficiency Non-retroviral Delivery of Genes Interfering with HIV-1 tat and gag," Gene Therapy (Eng.) 1:27-31 (Exhibit 22). |
Ohkawa, J. et al. (1993) "Importance of Independence in Ribozyme Reactions: Kinetic Behavior of Trimmed and of Simply Connected Multiple Ribozymes with Potential Activity Against Human Immunodeficiency Virus," Proc. Natl. Acad. Sci. USA 90:11302-11306 (Exhibit 23). |
Ohkawa, J. et al. (1993) "Multiple Site-Specific Cleavage of HIV RNA by Transcribed Ribozymes from Shotgun-Type Trimming Plasmid," Nucleic Acids Symp. Ser. (Eng.) 29:121-122 (Exhibit 24). |
Ojwang, J.O. et al. (1992) "Inhibition of Human Immunodeficiency Virus Type 1 Expression by a Hairpin Ribozyme," Proc. Natl. Acad. Sci. USA 89:10802-10806 (Exhibit 25). |
Rossi, J.J. et al. (1992) "Catalytic Antisense RNA (Ribozymes): Their Potential and Use as Anti-HIV-1 Therapeutic Agents," Adv. Exp. Med. Biol. (USA) 312:95-109 (Exhibit 26). |
Rossi, J.J. et al. (1992) "Ribozymes as Anti-HIV-1 Therapeutic Agents: Principles, Applications, and Problems," AIDS Res. Hum. Retroviruses (USA) 8:183-189 (Exhibit 27). |
Rossi, J.J. et al. (1990) "Ribozymes as Therapies for AIDS," Ann. N.Y. Acad. Sci. (USA) 616:184-200 (Exhibit 28). |
Sarver, N. (1991) "Ribozymes: A New Frontier in Anti-HIV Strategy," Antisense Res. Dev. (USA) 1:373-378 (Exhibit 29). |
Sarver, N. et al. (1990) "Ribozymes as Potential Anti-HIV-1 Therapeutic Agents," Science 247:1222-1225 (Exhibit 30). |
Shimayama, T. et al. (1993) "Cleavage of the Highly Conserved Hairpin-Loop Region of HIV-1 by Synthetic Ribozymes," Nucleic Acids Symp. Ser. (Eng.) 29:177-178 (Exhibit 31). |
Taylor, N.R. and Rossi, J.J. (1991) "Ribozyme-Mediated Cleavage of a HIV-1 gag RNA: The Effects of Nontargeted Sequences and Secondary Structure on Ribozyme Cleavage Activity," Antisense Res. Dev. 1:173-186 (Exhibit 32). |
Thill, G. et al. (1993) "Structural and Sequence Elements Required for the Self-Cleaving Activity of the Hepatitis Delta Virus Ribozyme," Biochemistry 32:4254-4262 (Exhibit 33). |
Weerasinghe, M. et al. (1991) "Resistance to Human Immunodeficiency Virus Type 1 (HIV-1) Infection in Human CD4.sup.+ Lymphocyte-Derived Cell Lines Conferred by Using Retroviral Vectors Expressing an HIV-1 RNA-Specific Ribozyme," J. Virol (USA) 65: 5531-5534 (Exhibit 34). |
Yamada, O. et al. (1994) "Intracellular Immunization of Human T Cells with a Hairpin Ribozyme Against Human Immunodeficiency Virus Type 1," Gene Therapy (Eng.) 1:38-45 (Exhibit 35). |
Yu, M. et al. (1993) "A Hairpin Ribozyme Inhibits Expression of Diverse Strains of Human Immunodeficiency Virus Type 1," Proc. Natl.Acad.Sci. USA 90:6340-6344 (Exhibit 36). |
Zaia, J.A. et al. (1992) "Status of Ribozyme and Antisense-Based Developmental Approaches for Anti-HIV-1 Therapy," Ann N.Y. Acad. Sci (USA) 660:95-106 (Exhibit 37). |