Claims
- 1. A recombinant protein comprising a ricin A chain, a ricin B chain and a heterologous linker amino acid sequence, linking the A and B chains, wherein the linker sequence contains a cleavage recognition site for a matrix metalloproteinase.
- 2. The recombinant protein of claim 1 having the linker amino acid sequence according to SEQ ID NO: 43.
- 3. The recombinant protein of claim 1, wherein the matrix metalloproteina is matrix metalloproteinase-9.
- 4. A pharmaceutical composition for treating cancer or a fungal, or viral, or parasitic infection in an animal comprising the recombinant protein of claim 1 and a pharmaceutically acceptable carrier, diluent or exciplent.
Parent Case Info
This is a continuation-in-part of U.S. patent application Ser. No. 09/403,752 fied Oct. 29, 1999 which is a 371 of PCT/CA98/00394 issued Apr. 30, 1998.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
6531125 |
Borgford |
Mar 2003 |
B1 |
Foreign Referenced Citations (1)
Number |
Date |
Country |
WO 9741233 |
Nov 1997 |
WO |
Non-Patent Literature Citations (2)
Entry |
Sampson M. T. et al. (2003) Coagulation proteases and human cancer. Biochem. Soc. Trans. vol. 30, pp. 201-207. Review.* |
Westby, M. et al. (1992) Preparation and characterization of recombinant proricin containing an alternative protease-sensitive linker sequence. Bioconjug. Chem. vol. 3, pp. 375-381. |
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
09/403752 |
|
US |
Child |
09/551151 |
|
US |